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Practical Neurology

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https://www.readbyqxmd.com/read/29331987/what-to-look-for-in-winter-a-memoir-in-blindness
#1
Phil E M Smith
No abstract text is available yet for this article.
January 13, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29326240/neuropsychological-assessment-in-epilepsy
#2
EDITORIAL
Sallie Baxendale
The role of the neuropsychological assessment in the management of people with epilepsy has evolved considerably over the past 25 years. This paper describes some of the most common applications of a neuropsychological assessment in the diagnosis, management and treatment of people with epilepsy. It describes the factors that influence the interpretation of neuropsychological test scores in this patient group and outlines the limitations of the investigation. It gives guidelines for the optimal timing of a referral, together with timelines and indications for reassessment, and provides a checklist to help the referring clinician get the most from a neuropsychological assessment for their patients with epilepsy...
January 11, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29305493/persistent-postural-perceptual-dizziness-a-useful-new-syndrome
#3
EDITORIAL
Barry M Seemungal, Luca Passamonti
No abstract text is available yet for this article.
January 4, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29305492/oromandibular-chorea-in-antiphospholipid-syndrome
#4
EDITORIAL
Liqun Zhang, Anthony C Pereira
No abstract text is available yet for this article.
January 4, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29288212/cerebral-arterial-gas-embolism-from-attempted-mechanical-thrombectomy-recovery-following-hyperbaric-oxygen-therapy
#5
Louise Segan, Fiona Permezel, Wei Ch'ng, Ian Millar, Mark Brooks, Matt Lee-Archer, Geoffrey Cloud
Cerebral arterial gas embolism is a recognised complication of endovascular intervention with an estimated incidence of 0.08%. Its diagnosis is predominantly clinical, supported by neuroimaging. The treatment relies on alleviating mechanical obstruction and reversing the proinflammatory processes that contribute to tissue ischaemia. Hyperbaric oxygen therapy is an effective treatment and has multiple mechanisms to reverse the pathological processes involved in cerebral arterial gas embolism. Symptomatic cerebral arterial gas embolism is a rare complication of endovascular intervention for acute ischaemic stroke...
December 28, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29288211/neurological-complications-of-renal-dialysis-and-transplantation
#6
REVIEW
Kushan Karunaratne, David Taube, Nofal Khalil, Richard Perry, Paresh A Malhotra
Neurological complications from renal replacement therapy contribute significantly to morbidity and mortality in patients with renal failure. Such complications can affect either the central or peripheral nervous systems. Most neurological disturbances associated with the uraemic state do not respond fully to renal replacement therapy. There are also complications specifically associated with dialysis and transplantation. A multidisciplinary approach, involving both nephrologists and neurologists, is critical for the diagnosis and effective management of these disorders...
December 28, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29273616/epilepsy-and-psychosis-a-practical-approach
#7
REVIEW
Melissa Maguire, Jasvinder Singh, Anthony Marson
The psychoses of epilepsy can be classified according to their temporal relationship with seizures, namely as ictal, postictal and interictal psychosis. Interictal psychosis is the most common and may resemble schizophrenia. They can be challenging to diagnose and to manage, especially given the perception that some antipsychotic drugs may exacerbate seizures, while some antiepileptic medications may worsen psychosis. The current uncertainty around their best management means that some patients may not receive appropriate care...
December 22, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29273615/longitudinally-extensive-transverse-myelitis-after-campylobacter-jejuni-enteritis
#8
Yudy Llamas, Karl Hazel, Patrick Nicholson, Lisa Costelloe
Campylobacter jejuni infection is well-known to precipitate Guillain-Barré syndrome through an immune-mediated attack on the peripheral nervous system. Molecular mimicry between C. jejuni lipo-oligosaccharides on the surface of infectious agents and human gangliosides in the peripheral nerves induces cross-reactive immune responses. Although gangliosides also occur in the central nervous system (CNS), autoimmune CNS disorders rarely follow Cjejuni infections. However, longitudinally extensive transverse myelitis commonly has a parainfectious cause, triggered by a wide range of micro-organisms including viruses and bacteria...
December 22, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29263135/moral-case-deliberation
#9
REVIEW
Daniel Y B Tan, Bastiaan C Ter Meulen, Albert Molewijk, Guy Widdershoven
Ethical dilemmas in general are characterised by a choice between two mutually excluding options neither of which is satisfactory, because there always will be a form of moral damage. Within the context of medicine several ethics support services have been developed to support healthcare professionals in dealing with ethical dilemmas, including moral case deliberation. In this article, we describe how moral case deliberation works in daily practice, illustrated with a case example from the neurology ward. The article is meant as an introduction to moral case deliberation according to the dilemma method...
December 20, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29223998/cryptococcal-meningitis-in-apparently-immunocompetent-patients-association-with-idiopathic-cd4-lymphopenia
#10
Samuel Shribman, Alastair Noyce, Sharmilee Gnanapavan, Jonathan Lambourne, Thomas Harrison, Frederick Schon
We present two cases of cryptococcal meningitis in people subsequently diagnosed with idiopathic CD4+ lymphopenia. Both presented with new onset headaches without sinister features and were sent home on multiple occasions from emergency departments. Cryptococcal meningitis in HIV-negative patients poses major diagnostic and management problems; the associated mortality is 9%-27%. We suggest performing blood and cerebrospinal fluid cryptococcal antigen tests in all people with lymphocytic meningitis.
December 9, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29223997/more-than-meets-the-eye-in-a-migraine
#11
Jonathan Rhys Evans, Jagrit Shan
No abstract text is available yet for this article.
December 9, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29223996/metabolic-myopathies-a-practical-approach
#12
REVIEW
James B Lilleker, Yann Shern Keh, Federico Roncaroli, Reena Sharma, Mark Roberts
Metabolic myopathies are a diverse group of rare genetic disorders and their associated muscle symptoms may be subtle. Patients may present with indolent myopathic features, exercise intolerance or recurrent rhabdomyolysis. Diagnostic delays are common and clinicians need a high index of suspicion to recognise and differentiate metabolic myopathies from other conditions that present in a similar fashion. Standard laboratory tests may be normal or non-specific, particularly between symptomatic episodes. Targeted enzyme activity measurement and next-generation genetic sequencing are increasingly used...
December 9, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29212862/ataxia-with-oculomotor-apraxia-type-2-an-evolving-axonal-neuropathy
#13
Tahira N Choudry, David Hilton-Jones, Graham Lennox, Henry Houlden
A 23-year-old woman had presented initially to a podiatrist complaining of poorly fitting shoes during her adolescence. After extensive neurological review, she was diagnosed with ataxia with oculomotor apraxia type 2. This is a progressive autosomal recessive ataxia associated with cerebellar atrophy, peripheral neuropathy and an elevated serum α-fetoprotein. Within Europe, it is the most frequent autosomal recessive ataxia after Friedreich's ataxia and is due to mutations in the senataxin (SETX) gene. The age of onset is approximately 15 years...
December 6, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29208731/misleading-signs-in-acute-vertigo
#14
Sean Lance, Stuart Scott Mossman
The acute vestibular syndrome is common and usually has a benign cause. Sometimes, however, even experienced neurologists can find it difficult to determine the cause clinically. Furthermore, neuroimaging is known to be insensitive.We describe two cases of acute vestibular syndrome where conflicting clinical findings contributed to a delay in making the correct diagnosis. The first patient with symptomatic vertigo had signs consistent with horizontal benign paroxysmal positional vertigo but also had an abnormal horizontal head impulse test, superficially suggesting acute vestibular neuritis but later accounted for by the finding of a vestibular schwannoma (acoustic neuroma)...
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29208730/rituximab-for-corticosteroid-resistant-relapsing-igg4-related-intracranial-pachymeningitis-report-of-two-cases
#15
Arthur Mageau, Natalia Shor, Matthieu Fisselier, Jennifer Aboab, Augustin Lecler, Celeste Rebours, Homa Adle-Biassette, Olivier Gout, Romain Deschamps
IgG4-related disease is now recognised as an important cause of intracranial and spinal hypertrophic pachymeningitis. Treatment with corticosteroids generally leads to significant clinical improvement. We present two cases of IgG4 pachymeningitis unresponsive to corticosteroids who improved with rituximab.
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29208728/imaging-in-low-grade-glioma-a-guide-for-neurologists
#16
REVIEW
Jennifer Larsen, Nigel Hoggard, Fiona M McKevitt
The management of low-grade glioma (LGG) is shifting as evidence has emergedthat refutes the previously commonplace imaging-based 'watch and wait' approach, in favour of early aggressive surgical resection. This coupled with the recent 2016 update to the World Health Organisation Classification of Tumours of the Central Nervous System is changing LGG imaging and management. Recently in Practical Neurology the contemporary management of low-grade glioma and the changes to this grading system were discussed in detail...
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29175875/late-diagnosis-of-homocystinuria-in-an-adult-after-extensive-cerebral-venous-thrombosis
#17
EDITORIAL
Sonia Quintas, Julio Dotor-García Soto, María Concepción Alonso-Cerezo, Maria Teresa Carreras
No abstract text is available yet for this article.
November 24, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29175874/psychiatric-disease-in-an-adolescent-as-a-harbinger-of-cerebral-x-linked-adrenoleukodystrophy
#18
Jessica Smith, Mitchel T Williams, Vinod K Misra
X-linked adrenoleukodystrophy (XALD) typically presents as a childhood cerebral demyelinating form, as an adult-onset adrenomyeloneuropathy or as adrenocortical insufficiency. Cerebral demyelination presenting in adolescence is unusual. We present an 17-year-old boy with adolescent-onset XALD initially manifesting with slowly progressive psychiatric symptoms. He was initially diagnosed with attention-deficit hyperactivity disorder and an acute psychosis. However, he was ultimately diagnosed with XALD based on his clinical course, neuroimaging findings and biochemical abnormalities...
November 24, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29175873/crowned-dens-syndrome
#19
David Ledingham, Cecilia Cappelen-Smith, Dennis Cordato
Crowned dens syndrome is a rare presentation of calcium pyrophosphate deposition disease. It is characterised by severe occipital pain and neck stiffness. Acute presentations are typically accompanied by fever and an inflammatory response and hence can be misdiagnosed as polymyalgia rheumatica or meningitis. Chronic relapsing presentations may be misdiagnosed as cervicogenic neck pain or occipital neuralgia. We present a patient who presented with a chronic relapsing form of crowned dens syndrome and discuss the epidemiology, typical presentation and management of this eminently treatable condition...
November 24, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29123022/the-shaking-woman-or-a-history-of-my-nerves-by-siri-hustvedt
#20
Fiona Moreton, Tim Wilkinson
No abstract text is available yet for this article.
November 9, 2017: Practical Neurology
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