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Asian Pacific Journal of Cancer Prevention: APJCP

Satar Rezaei, Behzad Karami Matin, Ali Kazemi Karyani, Abraha Woldemichael, Farid Khosravi, Masoud Khosravipour, Shahab Rezaeian
This study was aimed at assessing any association between smoking and health-related quality of life (HRQoL) among adults aged 18 years and above living in Kermanshah city, western Iran. A cross-sectional study was conducted on a total sample of 1,543 participants obtained by convenient sampling during the period from February 1st to May 30th, 2017. Data were collected using a self-administrated questionnaire. The HRQoL of the study participants was assessed with reference to the EuroQol 5-dimensions-3-level (EQ-5D-3L)...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Kaori Okayama, Mitsuaki Okodo, Hiroshi Kitamura, Ichiro Itoda
Purpose: The incidence of invasive anal cancer (IAC) has been increasing among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). Although cytological diagnosis is the modality of choice for screening cases of IAC, it is associated with lower sensitivity and specificity. Therefore, the present study aimed to evaluate new cytological signs of human papillomavirus (HPV) infection that may contribute to improving anal cytology. Methods: Anal cytology and HPV testing were performed using SurePath liquid-based cytology on samples obtained from 37 HIV-positive Japanese MSM...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Samah Mamdouh, Fatma Khorshed, Tarek Aboushousha, Hussam Hamdy, Ayman Diab, Mohamed Seleem, Mohamed Saber
HCV induced hepatitis and hepatocellular carcinoma as its sequel are major health problems world-wide and especially in Egypt. For diagnosis and during treatment of liver diseases, liver functions are monitored through determination of serum levels of liver enzymes and α-fetoprotein although the obtained information is generally not sufficient for either early detection of hepatic insult or effective follow up of therapeutic effects. More sensitive biomarkers may help to achieve these goals. MiRNAs are small non-coding RNAs that have an important role in gene expression and regulation...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Sreenivasulu Palugulla, Dimpal N Thakkar, Smita Kayal, Sunil K Narayan, Steven Aibor Dkhar
Oxaliplatin is a platinum drug active against digestive tract cancers. Among its side effects, peripheral neuropathy is one of the dose-limiting toxicities. This affects around 50 to 70% of patients but the pathophysiology of development of oxaliplatin-induced peripheral neuropathy (OXAIPN) remains unclear. Sodium channels (SCNAs) play major role in neuronal electrical signaling processes and mutations in SCNAs lead to various neuronal diseases involving the central and peripheral nervous systems. In this study, we evaluated whether SCNA genetic variants might be associated with risk of chronic OXAIPN in patients with digestive tract cancers treated with oxaliplatin...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Ozgur Tanriverdi, Ibrahim Barista, Semra Paydas, Erdinc Nayir, Yusuf Karakas
In this study, we aimed to determine the perspectives of medical and radiation oncologists regarding consolidation radiotherapy in patients with a complete response after chemotherapy for Hodgkin’s and non-Hodgkin’s lymphomas. The survey was designed to identify demographic and occupational features of medical and radiation oncologists and their views on application of consolidation radiotherapy in their clinical practices, as based on a five-point Likert scale (never, rarely, sometimes, often, and always)...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
S Saraswathi, L Mary Immaculate Sheela
Detection of lung cancer through image processing is an important tool for diagnosis. In recent years, image processing techniques have become more widely used. Lung segmentation is an essential pre-processing step for most (CAD) schemes. An automated system is proposed in this paper for identifying lung cancer from the analysis of computed tomography images by performing nodule segmentation using an optimal critical point selection algorithm (OCPS) which improves the detection of shape- and size-based juxtapleural nodules located at the lung boundary...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Suchada Sommaluan, Budsaba Rerkamnuaychoke, Teeraya Pauwilai, Suporn Chancharunee, Preeyaporn Onsod, Pitichai Pornsarayuth, Takol Chareonsirisuthigul, Rachaneekorn Tammachote, Teerapong Siriboonpiputtana
Multiple myeloma (MM) is a hematological malignancy characterized by abnormal accumulation of clonal plasma cells in the bone marrow. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged as an effective and robust method for detection of common genetic alterations in MM patients. Here, we aimed to confirm MLPA utility for this purpose and furthermore to test the feasibility of a combination of karyotyping, interphase fluorescence in situ hybridization (iFISH) and MLPA methods for diagnosis, prognostic assessment and risk stratification of MM...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Hamidreza Jamaati, Naghmeh Bahrami, Payam Tabarsi, Adnan Khosravi, Arda Kiani, Atefeh Abedini, Rahim Ahmadi, Somayeh Sharifynia, Abdolreza Mohamadnia
Background: Anthracosis of the lung occurs due to the deposition of carbon and silica in the mucosa and submucosa, manifested as black lesions. The association of anthracosis with lung cancer has remained to be clearly elucidated The current study aimed to assess the P16, CDH1 and LUNX genes expression level to evaluate the association of anthracotic lesions in the lungs with the occurrence of non-small cell lung cancer. Methods: Forty biopsy samples were taken from the center and 40 from the margins of black anthracotic lesions in the lungs; RNA was extracted from the samples and cDNA was synthesized...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Mohammad Hussain Hamrah, Mohammad Shoaib Hamrah, Mohammad Hassan Hamrah, Mitsuro Kanda, Ahmad Edris Hamrah, Ahmad Elias Dahi, Farhat Homayoun, Mohammad Hashem Hamrah, Akbar Fotouhi, Junichi Sakamoto
Background: The prevalence of Helicobacter pylori (H. pylori) infection is reported to be more than 50% worldwide. It has been associated with peptic ulcer disease, gastric carcinoma, and mucosal-associated lymphoid tissue lymphoma. The seroprevalence of H. pylori varies greatly among societies and geographical locations. The objective of this study was to determine the seroprevalence and factors associated with H. pylori infection among dyspeptic patients in Afghanistan. Materials and Methods: This cross-sectional study was designed to determine the seroprevalence of H...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Bayan Maraqa, Isam Lataifeh, Lian Otay, Osama Badran, Yasar Qutaiba Nouri, Ibtihal Issam, Maysa Al Hussaini
Background and aims: Cervical cancer is the fourth most common cancer in women worldwide and the 13th in Jordan. The cervical smear (Pap smear) is a simple approach to detect pre-cancerous cervical lesions. The aim of this study was to evaluate the prevalence of abnormal cervical smears in women seen at the Early Detection/Community Outreach clinic of King Hussein Cancer Center (KHCC). Materials and Methods: In this retrospective study, reports of routine cervical Pap smears performed in the pathology department at KHCC from January 2007 to December 2016, were reviewed...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Yamato Fukui, Ayumi Taguchi, Katsuyuki Adachi, Marie Sato, Akira Kawata, Michihiro Tanikawa, Kenbun Sone, Mayuyo Mori, Kazunori Nagasaka, Yoko Matsumoto, Takahide Arimoto, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii
Background: The most studied fertility-sparing therapy for endometrial cancer (EC) is oral progestin therapy. However, complete remission (CR) rate after progestin therapy is not enough ranging from 60 to 80 %, with high recurrence rate. Clinical features that predict treatment efficacy and recurrence after progestin therapy have not yet been revealed in detail. The aim of this study was to investigate prognostic factors in patients with EC who achieved CR after medroxyprogesterone acetate (MPA) therapy. Methods: We retrospectively reviewed 35 EC patients treated with MPA at our institution between 2000 and 2016...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Reza Hosseini Ghatar, Tahereh Soltantoyeh, Tannaz Bahadori, Maryam Golara, Hadi Hassannia, Roya Khosravi Eghbal, Jalal Khoshnoodi, Mohammad Ali Judaki, Forough Golsaz-Shirazi, Mahmood Jeddi-Tehrani, Mohammad Mehdi Amiri, Fazel Shokri
Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in several human malignancies and numerous studies have indicated that it plays important roles in the development and maintenance of the malignant phenotype. Targeting of HER2 molecules with monoclonal antibodies (mAbs) is a promising therapeutic approach. However, anti-HER2 mAbs affect cancer cells differently, depending on the distinct epitopes which are the targets. Methods: Reactivity of a panel of 8 mouse anti-HER2 mAbs was investigated by ELISA and Western blotting using different subdomains of the extracellular domain (ECD) of HER2...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Wisit Chaveepojnkamjorn, Rungsinoppadol Thotong, Pratana Sativipawee, Supachai Pitikultang
Background: Breast cancer (BC) is the leading malignancy in women with high incidence and mortality worldwide. Obesity is one of several established risk factors for chronic diseases including cancer. The objective of this research was to determine the association of body mass index (BMI) with BC among Thai premenopausal women (TPW). Materials and Methods: A case-control study was conducted among TPW attending the National Cancer Institute in Bangkok, with 257 cases and 257 controls in 2013-2014. Cases and controls were matched by age (± 5 years), residential area and duration of attending...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Parichart Boueroy, Ratchadawan Aukkanimart, Thidarut Boonmars, Pranee Sriraj, Panaratana Ratanasuwan, Amornrat Juasook, Nadchanan Wonkchalee, Kulthida Vaeteewoottacharn, Sopit Wongkham
Aspirin and other non-steroidal anti-inflammatory drugs reduce the risk of cancer due to their anti-proliferative and apoptotic effects, which are the important mechanisms for their anti-tumor activity. Here, the effect of aspirin on human cholangiocarcinoma cells (KKU-214) and the underlying mechanisms of its action were explored. Cell proliferation was measured by sulforhodamine B (SRB) assay, while cell cycle distribution and apoptosis were determined by flow cytometry. Western blotting was used to explore protein expression underlying molecular mechanisms of anti-cancer treatment of aspirin...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Sareh Farhadi, Maryam Mohamadi, Mehdi Mohamadi
Background: Smoking is one of the major risk factors for cancers, especially in the oral cavity. Nuclear changes occur in the early stages of cancer. The aim of this study was therefore to investigate nuclear changes and calculate a “repair index” for the buccal mucosa of smokers. Material and Methods: This historical cohort study was conducted by selecting samples including smokers and non-smokers. In addition, the smoker group were divided into 2 subgroups with a smoking history of >10 and ≤10 years...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Karolina Stanienda-Sokół, Natalia Salwowska, Martyna Sławińska, Katarzyna Wicherska-Pawłowska, Anna Lorenc, Dominika Wcisło-Dziadecka, Jerzy Wydmański, Wojciech Majewski
Introduction: Location of malignant melanoma lesions depends on environmental, genetic, sociological and demographical factors. Available sources do not provide enough information on such dependencies in various populations. There is no data concerning the role of socio-demographic factors for the population of the Central and Eastern Europe. Aim: The aim of this work was to evaluate the anatomical location of the primary malignant melanoma lesion in correlation to patients’ gender and age. Material and methods: A retrospective analysis of medical documentation of 363 patients has been performed...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Namita Pandey, Soumyadip Pal, Lokesh Kumar Sharma, Randeep Guleria, Anant Mohan, Tapasya Srivastava
Background: The 15q24-25 loci contain genes (CHRNA5 and CHRNA3) encoding nicotinic acetylcholine receptor subunits. We here determined for the first time the association of genetic variants rs16969968 and rs3743074 in CHRNA5 and CHRNA3, respectively, on nicotine dependence and lung cancer risk in a North Indian population by a case-control approach. Methods: Venous blood samples were obtained from 324 participants (108 lung cancer patients and 216 healthy individuals). DNA was extracted and PCR amplified with primers flanking the SNPs rs16969968 and rs3743074...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
May Thuu Mon, Supachai Yodkeeree, Wanisa Punfa, Sonthaya Umsumarng, Suree Lekwanavijit, Sumalee Siriaunkgul, Prapaporn Suprasert, Pornngarm Limtrakul
Objective: Our goal was to determine the ex-vivo drug resistance assay, as well as the cytokine production, in response to platinum-based chemotherapy treatment in primary culture cells established from the tumor tissue of ovarian or fallopian tube carcinoma patients, and to predict the clinical responses to chemotherapy. Methods: Sensitivity to the platinum-based drug was analyzed in two ovarian cancer cell lines and 19 tumor samples using the primary cell culture obtained from 19 patients having ovarian or fallopian tube cancer that had undergone surgery from 2014 to 2017...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Mahdieh Salemi, Saeed Mohammadi, Ardeshir Ghavamzadeh, Mohsen Nikbakht
Acute myeloid leukemias (AMLs) are blood disorders that exhibit uncontrolled growth and reduction of apoptosis rates. As with other malignancies, progression may be result of induction and formation of new blood vessels influenced by disease conditions. Cancer cells produce a variety of factors which play important roles in angiogenesis. Vascular endothelial growth factor (VEGF) is critical for many malignancies, including AMLs. Curcumin, as a natural compound, is able to enhance apoptosis via a mechanism affecting regulatory genes...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Enam Alhagh Charkhat Gorgich, Zahra Heidari, Hamidreza Mahmoudzadeh- Sagheb
Background: Colorectal cancer (CRC) is one of the most common neoplasms with high mortality at advanced stages worldwide. Thus diagnosis of CRC at an early stage with sensitive molecular methods is a high priority. The aim of this study was to evaluate P16ink4a subcellular expression patterns in colorectal adenocarcinoma, adenoma and non-neoplastic tissue samples. Methods: A total of 137 colorectal formalin fixed paraffin-embedded tissue blocks from the pathology archives of Ali-Ebne-Abitaleb central hospital, Zahedan, Iran, were examined in three groups: adenocarcinoma (n= 63), adenoma (n= 38) and non-neoplastic (n= 36)...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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