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Asian Pacific Journal of Cancer Prevention: APJCP

Jitrapa Kerdsuknirun, Virunpat Vilaichone, Ratha-Korn Vilaichone
Objective: Hepatocellular carcinoma (HCC) is common cancer in ASEAN. Variceal bleeding (VB) is considered to be fatal complication of cirrhosis with HCC. However, limited studies were reported in ASEAN. Aim of this study was to evaluate overall survival rate and predictors of VB in HCC patients. Methods: We conducted a retrospective cohort study of HCC patients aged ≥15 years between January 2012-January 2016 and follow up through June 2016 at Thammasat University Hospital, Thailand. Clinical information and radiologic findings were collected from reviewing computer database of medical records...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mohammad Hadi Karbalaie Niya, Hossein Ajdarkosh, Fahimeh Safarnezhad Tameshkel, Mahshid Panahi, Maryam Tabasi, Behnaz Bouzari, Mahdi Alemrajabi, Hossein Keyvani
Background: Colorectal cancer (CRC) as a worldwide human health concern is identified being a multifactorial subject that infection with specific viral particles such as oncogenic viruses is research interest. Human bocavirus (HBoV) as a recent isolated virus has been investigated in many respiratory and enteric diseases but rare studies evaluates it in tissue specimens especially in cancerous sections. The aim of this study was to detect the presence of HBoV genome and its genotyping in CRC patient’s tissue and compare the result with matched healthy control group tissue...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Azam Shakery, Katayoun Pourvali, Arman Ghorbani, Samira Sadat Fereidani, Hamid Zand
Background: Beta-hydroxybutyrate (BHB) as a ketone body is the metabolic fuel in oxidative phosphorylation pathway. So far the effects of BHB on the biology of tumor cells is contradictory. Therefore, we investigated the effect of BHB on viability, metabolism, proliferation and migration of 5FU treated SW480 colon cancer cell line. Methods: we treated the SW480 cells with IC50 dose of 5-fluorouracil (5FU) for 72 h to isolate a subpopulation of 5FU treated cells that were resistant to it. Effects of BHB on cell viability was investigated by MTT assay...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Amer Takkem, Charif Barakat, Safa Zakaraia, Khaled Zaid, Johnny Najmeh, Mahdi Ayoub, Mohammad Yaman Seirawan
Introduction: Abnormal cell proliferation appears to be a possible predictor of tumorigenesis, Ki-67 protein expression is closely related to the cell proliferation and could be used as a biomarker for the growth in the most of human tumors. The aim of the study: Investigating of Ki-67 expression in the pathological grades of oral epithelial dysplasia and oral squamous cell carcinomas. Materials and Methods: The sample consisted of 30 formalin-fixed, paraffin-embedded specimens of oral epithelial dysplasia (OED), 30 other of oral squamous cell carcinomas (OSCC), and 10 normal oral epithelium (NOE) were conventionally stained with hematoxylin and eosin and immunohistochemically stained with Ki-67 monoclonal antibody...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Shin-Young Lee, Eunice Lee, Bulaporn Natipagon-Shah, Joy Toyama
Background: Few studies have examined preventive lifestyle behaviors and breast cancer (BC) screening behaviors simultaneously to determine whether BC screening behaviors are associated with preventive lifestyle behaviors. The purposes of this study are to (a) describe BC screening utilization and preventive lifestyle behaviors and (b) examine factors associated with BC utilization among Korean American (KA) women. Methods: Data from the 2015–2016 California Health Interview Survey were analyzed. Survey-weighted adjusted logistic regressions were used to determine whether preventive lifestyle behaviors and characteristics of KA women 50 years of age and older at the time of the survey were associated with obtaining mammograms...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Sharad Singh, S N Prasad, Mangesh Korde, Sunny Kumar, Aditya Elhence, Vaibhav Shakya
The region of head and neck is critical for respiration, nutrition, and speech. The management of laryngeal tumours can stimulate mutilations and cosmetic deformities and worsen the life. A “non-operative approach” is preferred for patients to whom radiation following surgery, possibly, will direct severe functional destruction predominantly in advanced stage patients having a bulk of carcinoma larynx. The case material for the study was selected from the cross-section of patients registered at the J. K...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Malathi M, Sinthia P
Generally the segmentation refers, the partitioning of an image into smaller regions to identify or locate the region of abnormality. Even though image segmentation is the challenging task in medical applications, due to contrary image, local observations of an image, noise image, non uniform texture of the images and so on. Many techniques are available for image segmentation, but still it requires to introduce an efficient, fast medical image segmentation methods. This research article introduces an efficient image segmentation method based on K means clustering integrated with a spatial Fuzzy C means clustering algorithms...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Sudhir Dutta, Balarama Krishna Surapaneni, Agam Bansal
Background: Globally Esophageal cancer is a common cancer arising from human esophageal mucosal tissue. Epidemiological studies suggest inverse correlation between carotenoid intake and incident risk of this devastating malignancy. Methods: In an effort to examine the modulatory role of carotenoids in human esophageal carcinogenesis at a cellular level, we examined the effects of α-carotene and β-carotenes, on cell proliferation and DNA synthesis in human esophageal epithelial (HEE) cells and human esophageal squamous cancer (HESC) cells in in-vitro cultures...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Elias Wael Youssef
Objective: This study tests the hypothesis that gingival tissue produces age-dependent activation of apoptotic markers. Methods: To address the hypothesis, a prospective experimental study was conducted on 20 adult male albino rats, which were divided into two groups. Group 1 comprised rats aged six months (weighing 150–200 g), and group 2 included old rats aged one year (weighing 250–300 g). Gingival tissue and buccal mucosa biopsy samples were obtained from both groups. Histological and immunohistochemical (Bax apoptotic protein marker) sections were analyzed for both groups...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Pamela Christudoss, Geeta Chacko, Ratnasamy Selvakumar, Jude J Fleming, Srinivasan Pugazhendhi, George Mathew
Background: Chemoprevention refers to the use of specificnatural or synthetic chemical agents to suppress the development and progression to carcinoma. The purpose of this study was to assess the effect of aspirin, vitamin C or zinc on the metallothionein (MT) mRNA gene expression as well as MT protein content byimmunohistochemistry andradioimmunoassay (RIA) in 1, 2-dimethyl hydrazine (DMH) induced cancerous colonic tissuein rats. Methods: Rats were randomly divided into three groups, group 1 (aspirin), group 2 (vitamin C) group 3 (zinc), each of which was further sub divided into two groups and given subcutaneous injections of DMH (30 mg/kg body weight) twice a week for 3 months and sacrificed at either 4 months (A-precancer model) or at 6 months (B-cancer model)...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Rahmi Aslan, Kerem Taken, Recep Eryılmaz
Purpose: Renal tumors are rarely seen in young adults. In this study, was aimed to report the data of 18-40 years old patients with Renal Cell Carcinoma (RCC) whom we operated. Material and Method: We retrospectively reviewed the data of patients between the ages of 18 and 40 years old patients who have renal masses. All patients were evaluated with chest X-ray, Computed tomography (CT) and/or MRI. Radical or partial nephrectomy was performed for clinical localized masses with malignancy suspicion. Clinicopathological features and survival data of all the patients were recorded...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mansour Moghimi, Saeed Kargar, Mohammad Ali Jafari, Hossein Ahrar, Mohammad Hossein Jarahzadeh, Hossein Neamatzadeh, Jalal Sadeghizadeh- Yazdi
Background: A number of case-control studies were conducted to investigate the association of angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism with breast cancer. But the results remain controversial. This meta-analysis aims to comprehensively evaluate the association of ACE I/D polymorphism with breast cancer. Method: A comprehensive literature search on PubMed, Google Scholar, SCOPUS and ISI Web of Knowledge databases for studies published up to June 01, 2018 was performed. Summary odds ratios (ORs) and 95% confidence intervals (CI) were estimated...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Toshiya Kuno, Hiroyuki Kato, Aya Naiki-Ito, Shugo Suzuki, Takuji Tanaka, Satoru Takahashi, Hideki Mori
Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is known to possess potentials to prevent chemical carcinogenesis in multiple organs of rodents. In the present study, possible chemopreventive effect of FBRA against spontaneous occurrence of lymphomas was examined using female AKR/NSlc mice. Four-week-old female AKR/ NSlc mice were divided into three groups, and fed diets containing FBRA for 26 weeks at a dose level 0% (Group 1), 5% (Group 2) or 10% (Group 3). At the termination of experiment, the incidence of thymic malignant lymphoma of Group 3 was significantly lower than of Group 1 (p < 0...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Behrooz Mozaffari Namin, Mohammad Mehdi Soltan Dallal
Background: Barrett’s oesophagus (BO) is a pre-malignant condition in which normal squamous epithelium of the lower oesophagus and gastresophageal junction is replaced by columnar cells and progress to oesophageal adenocarcinoma. The increase burden of oesophagus cancer morbidity and mortality worldwide make study of factors involved in the pathogenesis of BO essential. However, most of studies that examine the environmental risk factors associated with increased incidence and prevalence of BO have largely ignored the potential role of bacteria in disease aetiology...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
B Karthiga Jaya, S Senthil Kumar
Cervical cancer is the leading cancer in women around the world. In this paper, Adaptive Neuro Fuzzy Inference System (ANFIS) classifier based cervical cancer detection and segmentation methodology is proposed. This proposed system consists of the following stages as Image Registration, Feature extraction, Classifications and Segmentation. Fast Fourier Transform (FFT) is used for image registration. Then, Grey Level Co-occurrence Matrix (GLCM), Grey level and trinary features are extracted from the registered cervical image...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Rina Tanaka, Masashi Matsuzaka, Yoshihiro Sasaki
Background: Aomori Prefecture has experienced the highest cancer-related mortality rates since the 2000s in Japan. In addition, income of residents in Aomori Prefecture is lower than that of a countrywide average. Aims of this study were to examine the relationships of the incidence and mortality rates of common cancers (stomach, colorectal, liver, lung, breast, cervical, and prostate) with the income levels of residential income area and clarify the factors contributing to the high mortality rates in Aomori prefecture...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Abeer Ibrahim, Asmaa M Zahran, Sanaa Shaker Aly, Ahmed Refaat, Mohammed H Hassan
Background: Resistance to chemotherapy is a major obstacle to curing acute myeloid leukaemia (AML), and several antigens are claimed to play primary roles in this resistance. Purpose: The aim of this study was to evaluate the roles of CD56, CD11b and Smac/DIABLO gene expression levels as prognostic markers of the clinical outcome, response to chemotherapy and survival of AML patients. Materials and Methods: A cross-sectional observational study was conducted on 60 naïve-AML patients who received induction therapy with mitoxantrone and cytarabine combined with a high dose of cytarabine...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Muhammed Zübeyr Üçüncü, Merve Müge Üçüncü, Dilek Toprak
Background: Breast cancer is the most frequently diagnosed cancer among women in Turkey and worldwide, and is ranked as the second-leading cause of death in women after lung cancer. Early diagnosis of breast cancer is possible, and breast cancer is included in cancer-screening programs in Turkey. The aim of this study was to evaluate the knowledge, attitude, and behaviour of young women (older than 20 years of age) on breast self-examination and breast cancer screening methods, and to determine the effect of sociodemographic characteristics...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Isnaini Isnaini, Nur Permatasari, Karyono Mintaroem, Bunga Prihardina, M Aris Widodo
Reactive oxygen species (ROS) have various biological effects and they are non-linear in characteristic. In high oxidative stress, they may cause cytotoxicity, inhibit cell proliferation, and induce cell death in the form of apoptosis/necrosis; while in low or medium oxidative stress, ROS may cause DNA damage, cell mutation, inflammation, cell proliferation, and eventually they may induce carcinogenesis. Antioxidants are compounds with the ability to reduce ROS. Cell line MCF-7 is one of the breast cancer cell lines that is known to have small amount of antioxidant MnSOD compared to the other cell lines...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Sopit Tubtimhin, Supannee Promthet, Krittika Suwanrungruang, Pongsatorn Supaattagorn
Background and Purpose: This study focused on molecular subtypes and prognostic factors for survival of preand post-menopausal breast cancer patients. Methods: A retrospective cohort study was performed on 523 patients with invasive carcinoma of the breast treated at Ubon Ratchathani Cancer Hospital,Thailand from 2002 to 2016. Patient characteristics were collected based on a systematic chart audit from medical records. Prognostic factors were performed by observe survival analysis. A Cox regression model was used to calculate hazard ratios of death, taking into account the age and menopause status, molecular subtype, stage of disease, histological grade, lymphatic and vascular invasion, resection margin, hormone receptor expression, and treatment modality...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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