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Asian Pacific Journal of Cancer Prevention: APJCP

Refaat El-Fayoumi, Magda Hagras, Adel Abozenadaha, Waleed Bawazir, Thoraia Shinawi
Background: Glucocorticoids (GCs) are key hormones used for the treatment of acute lymphoblastic leukemia (ALL) in children, but their cytotoxic effects are not well defined. The aim of this study was to evaluate the association between polymorphisms in NR3C1 encoding for protein involved in the GCs metabolism and its role in the development of ALL and the toxicity outcome, in terms of liver toxicity, glucose abnormality and infections, in ALL Saudi children. Methods: The following polymorphisms BCII rs41423247, ER22/23 EK rs6189 and rs6190 and N363S rs6195 in NR3C1 were analyzed in 70 children with ALL treated according to the ALL 2000 study protocol in comparison to 60 control subjects...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Ratha Korn Vilaichone, Duc Trong Quach, Yoshio Yamaoka, Ken Sugano, Varocha Mahachai
Objective: Antibiotic resistance has significantly impact on eradication rates for H. pylori infection and remains important cause of treatment failure worldwide including ASEAN countries. The aim of this study was to survey the prevalence and antibiotic resistant pattern of H. pylori infection in ASEAN. Methods: This study was a survey among 26 experts from 9 ASEAN countries including Thailand, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore and Vietnam whom attended a meeting to develop the ASEAN consensus on H...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Roberta Pitta Costa Luz, Cinira Assad Simao Haddad, Samantha Karlla Lopes de Almeida Rizzi, Simone Elias, Afonso Celso Pinto Nazario, Gil Facina
Objective: To compare a complex physical therapy (CPT) protocol alone or combined with complex physical therapy muscle more strength training (CPT+ST) in patients with lymphedema after breast cancer treatment regarding strength and limb muscle volume. Methods: In this controlled clinical trial, consecutive patients treated from breast cancer from April 2014 to December 2015 were allocated in two groups, the CPT group 1 and the CPT+ST group 2, that performed CPT associated with muscle strengthening. Patients in the CPT group 1 received the routine protocol of care, consisting of manual lymphatic drainage (MLD), multilayer bandage compression therapy, skin care and regular exercises...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Zhong Guo Liang, Guo Xiang Lin, Jia Xiang Ye, Ye Li, Ling Li, Song Qu, Xia Liang, Xiao Dong Zhu
Background: It is unclear whether Cetuximab (CTX) or Nimotuzumab (NTZ) concurrent with radiotherapy delivers equivalent or improved results with fewer toxicities over standard cisplatin (CDDP) concurrent with radiotherapy in locally advanced nasopharyngeal carcinoma (NPC). Methods: The strategy involved searching the PubMed, Embase, Cochrane Library, China National Knowledge Internet Web, Wanfang and Chinese Biomedical databases. Controlled clinical trials that compared concurrent CTX/NTZ with radiotherapy versus CDDP with radiotherapy in local-regionally advanced NPC were included...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Shin Young Lee
Background: Colorectal cancer (CRC) is one of the most common cancers in Korean Americans (KAs) and CRC screening can detect CRC early and may reduce the incidence of CRC by leading to removal of precancerous polyps. Many KAs in the US leave the country, primarily to travel to Korea, for health screening. The aim of this study was to (a) assess CRC screening rates, including fecal occult blood test (FOBT), flexible sigmoidoscopy, and colonoscopy and (b) explore factors related to these tests among KAs by location of CRC screening...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Asmanaz Saleem Nadaf, Hephzibah Rani, Udipi Shastri Dinesh
Background and Objectives: Gastric cancer is the fourth most common cancer worldwide and ranks fifth in India. Surgical resection is curative in early stage gastric cancers. Most of the gastric cancers are diagnosed at an advanced stage necessitating multimodality treatment strategies. Based on the ToGA trial, the international regulatory agencies have recently approved trastuzumab in locally advanced and metastatic gastric and gastroesophageal adenocarcinomas expressing HER2. Since there are limited studies from India and no published data available from this part of North Karnataka, we undertook this study to evaluate the frequency of expression of HER2 in gastric and gastroesophageal adenocarcinomas and to correlate it with various clinicopathological variables...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Safa Zakaraia, Mamdouh Almohareb, Khaled Zaid, Mazen Doumani, Mohammad Yaman Seirawan
Amelogenin (AMEL), the major structural protein of the enamel organic matrix, constitutes more than 90% of the enamel’s protein content, Aberrations of amelogenin are thought to be involved in the oncogenesis of odontogenic epithelium. The expression of amelogenin is possibly an indicator of differentiation of epithelial cells in the odontogenic tumors. Aim of the study: Investigating the expression of amelogenin in some odontogenic tumors, using an anti-amelogenin polyclonal antibody, and then compare it with AMEL expression in tooth buds as control...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Kainat Khan, Shikha Tewari, Madhup Rastogi, Gaurav Raj Agarwal, Surendra Prasad Mishra, Nuzhat Husain
Background: Radiation causes oxidative lesions and strand breaks in DNA of exposed cells. Extended length PCR is a reliable method for assessing DNA damage. Longer DNA strands with DNA damage are difficult to amplify compared to smaller DNA strands by PCR. The present study was aimed to evaluate DNA damage caused by ionising radiation exposure in therapeutic and diagnostic medicine. Materials and Methods: The study group comprised 50 cases with low dose single exposure (LDS), low dose multiple exposure (LDM) and low dose angiography (LDA) which were compared with 25 high dose controls (HDC) and 25 controls with no exposure (NEC)...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Marieh Honarmand, Alireza Nakhaee, Mohammad Moradi
Objective: Smoking cigarettes and smokeless tobacco are one of the causes of oral cancer. This study compared the salivary level of cotinine in male smokeless tobacco users and smokers. Methods: In this cross-sectional (descriptive-analytical) study, stimulated saliva samples from 30 male smokers and 30 male smokeless tobacco consumers were collected and their cotinine contents were measured using the competitive ELISA method according the standard curve. The data was analyzed with independent t-test and linear regression using SPSS-19, and P<0...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Jamshid Motalebzadeh, Samira Shabani, Saeedeh Rezayati, Narges Shakournia, Rezvan Mirzaei, Bahar Mahjoubi, Kamal Hoseini, Frouzandeh Mahjoubi
Background: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite recent progress in diagnosis and treatment, it remains a major health problem and further studies are needed. We here investigated expression profiles of the FBXO39, ETS-1 and BMI-1 genes in CRCs to validate any possible diagnostic/prognostic significance. Material and Methods: Thirty six patients with locally advanced CRC admitted to Hazrate-Rasoul Hospital-Tehran were enrolled. Initially the expression pattern of FBXO39, ETS-1 and BMI-1 genes were determined using RT-PCR in CRC tumor and adjacent normal tissues then real-time RT-PCR was employed to quantify BMI-1 gene expression...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mehdi Mirzaei-Alavijeh, Parvaneh Ghorbani, Farzad Jalilian
Background: Mammography screening uptake is the most effective method in breast cancer screening. The aim of this study was to determine the determinants related to mammography screening uptake among Iranian women based on the theory of planned behavior. Materials and Methods: This cross-sectional study was conducted among 408 women who referred to health centers in Kermanshah city, the western of Iran, during 2016. Participants filled out a self-administered questionnaire. Data were analyzed by SPSS version 21 using Pearson correlation, linear and logistic regression statistical tests at 95% significant level...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Nayara Fernandes Pedro, Joice Matos Biselli, José Victor Maniglia, Dalísio de Santi-Neto, Érika Cristina Pavarino, Eny Maria Goloni-Bertollo, Patrícia Matos Biselli-Chicote
Background: Alteration in the biotransformation of exogenous compounds can result in production of reactive oxygen species (ROS), which can predispose cells to malignant transformation in the head and neck. This study aimed to evaluate the expression of genes involved in antioxidant metabolism in the oral squamous cell carcinoma (OSCC). Methods: The expression of eighty-four genes was evaluated in OSCC and non-tumor tissues by quantitative real-time polymerase chain reaction using the TaqMan Gene Expression Array...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Supanee Muangtan, Wineeya Suknikhom, Panya Sananpanichkul
Objective: To determine any association between the menopausal status and epithelial ovarian cancer coexisting with endometriosis (EOC-E). In addition, the prevalence and possible risk factors were assessed. Methods: Medical records of 172 women with epithelial ovarian cancer between January 2011 and December 2016 at Prapokklao Hospital were reviewed and divided into two groups: EOC-E defined as the case group and without endometriosis (EOC-NE) as the control group. Results: The proportion of EOC-E was 18% (31/172)...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Paweena Phaliwong, Piyawan Pariyawateekul, Nathaya Khuakoonratt, Worrawan Sirichai, Kornkarn Bhamarapravatana, Komsun Suwannarurk
Objectives: To determine the prevalence of abnormal Papanicolaou (Pap) smear, cervical intraepithelial neoplasia (CIN) 2 or higher and cancer between conventional Pap smear (CPP) and liquid based Pap smear (LBP). Methods: This retrospective study was conducted at Bhumibol Adulyadej Hospital, Bangkok, Thailand between January 2011 and December 2016. Data was collected from medical records of participants who attended for cervical cancer screening test. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for detecting CIN 2 or higher were evaluated by using the most severity of histopathology reports...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Satheesh K Bandhary, Veena Shetty, Marina Saldanha, Priya Gatti, Devananda Devegowda, Pushkal S R, Avinash K Shetty
Background: Head and Neck Squamous Cell Carcinomas (HNSCC) is the sixth most common cancer globally. In India, on an average 25-30% of all cancer cases affect the head and neck. The etiological factors associated with HNSCC are tobacco, alcohol and environmental carcinogens. However there are few cases, where there are no obvious risk factors involved. In western counties, there are many reports of human papilloma virus (HPV) association with HNSCC. Hence, we conducted a study to determine the role of HPV infection and risk factors among patients with HNSCC...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Maliheh Arab, Farzaneh Jamdar, Maryam Sadat Hosseini, Robabe Ghodssi- Ghasemabadi, Farah Farzaneh, Tahereh Ashrafganjoei
Background: Primary cytoreduction surgery followed by chemotherapy is the cornerstone treatment for epithelial ovarian cancer (EOC). In patients with a low probability of optimal primary surgical debulking, neoadjuvant chemotherapy (NACT) followed by interval debulking increases the chance of optimal surgery. The aim of this study was to develop a model to identify preoperative predictors for suboptimal cytoreduction. Methods: Medical records of patients with EOC who underwent primary cytoreductive surgery in a referral tertiary gyneco-oncology center were reviewed from 2007 to 2017...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Seyed Mohammadreza Bitaraf, Reihaneh Alsadat Mahmoudian, Mohammadreza Abbaszadegan, Anahita Mohseni Meybodi, Negin Taghehchian, Atena Mansouri, Mohammad Mahdi Forghanifard, Bahram Memar, Mehran Gholamin
Objective: CD44 is an important cell adhesion molecule that plays a key role in growth, invasion, proliferation and metastasis of cancer cells. CD44 protein over-expression is associated with a poor prognosis of gastric cancer (GC) and previous studies have shown that CD44 gene polymorphisms could affect survival and recurrence. In this study, we tested the hypothesis that polymorphisms impacting on the CD44 signaling pathway may predict clinical outcomes in patients with GC. Materials and Methods: DNA was extracted from blood of 150 healthy individuals and formalin-fixed paraffin-embedded (FFPE) tumor tissue of 150 patients...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Leila Khanali Mojen, Maryam Rassouli, Peyman Eshghi, Kazem Zendedel, Ali Akbari Sari, Majideh Heravi Karimooi, Mamak Tahmasebi, Azam Shirin Abadi Farahani
Background: Establishing palliative care services is a priority in the health system of Iran. Considering the necessity of integrating these services into the health system, this study aimed to explore the stakeholders’ perceptions about the provision of a conceptual framework for palliative care services for children with cancer according to the health system in of Iran. Methods: The present qualitative study was conducted through in-depth semi-structured interviews held with 29 participants including palliative care specialists, policy-makers, health care providers, the parents of children with cancer selected through purposive sampling, between August 2016 and February 2017...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Putsarat Insin, Nisa Prueksaritanond
Objectives: To compare survival outcomes between endometrial cancer (EC) patients with diabetes who used metformin to those who did not use metformin. Materials and Methods: A retrospective cohort study was conducted of EC patients who were diabetes at the time of their cancer diagnosis and had been scheduled for elective surgery at Rajavithi Hospital between 1 January 2003 and 31 December 2013. The patients were excluded if they had type I diabetes mellitus and a history of other cancers. Results: Of 1,262 EC patients in the study period, there was 212 (16...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Adiel Goes de Figueiredo Junior, Patrícia Valéria Pereira Serafim, Augusto Azzolini de Melo, Aledson Vitor Felipe, Edson Guimarães Lo Turco, Ismael Dale Cotrim Guerreiro da Silva, Nora Manoukian Forones
Backgrounds: Colorectal (CRC) is one of the main cause of cancer worldwide. The search for noninvasive markers for diagnosis and monitoring as the use of analytical technologies such as mass spectrometry (MS), which allowed the search for lipid metabolites as candidates for probable biomarkers are needed. Objective and Methods: The objective was to establish the lipid profile of patients with locally advanced, unresectable or metastatic CRC. Peripheral blood was collected from patients with CRC and controls with normal colonoscopy...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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