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Asian Pacific Journal of Cancer Prevention: APJCP

Yakup Bozkaya, Nuriye Yıldırım Özdemir, Ozan Yazıcı, Nebi Serkan Demirci, Alican Kurtipek, Gökmen Umut Erdem, Yakup Ergün, Nurullah Zengin
Objective: We aimed to evaluate the effectiveness of an mEOX (modified epirubicin, oxaliplatin plus capecitabine) regimen as second line therapy after failure of mDCF (modified docetaxel, cisplatin plus fluorouracil). Methods: Gastic cancer patients for whom first-line therapy was unsuccessful and who subsequently received mEOX (epirubicin 50 mg/ m2 on day 1, oxaliplatin 85 mg/m² day 1 and capecitabine twice-daily dose of 625 mg/ m2, p.o. for 2 weeks) every 3 weeks until disease progression or unacceptable toxicity, were retrospectively analyzed...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Meenaakshi Sundhari R P
Objective: The method to treating cancer that combines light and light-sensitive drugs to selectively destroy tumour cells without harming healthy tissue is called photodynamic therapy (PDT). It requires accurate data for light dose distribution, generated with scalable algorithms. One of the benchmark approaches involves Monte Carlo (MC) simulations. This gives an accurate assessment of light dose distribution, but is very demanding in computation time, which prevents routine application for treatment planning...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Putthikrai Pramual, Pongdech Sarakarn, Siriporn Kamsa-ard, Chananya Jirapornkul, Naowarat Maneenin, Prasert Thavondunstid, Prachak Juntarach, Supannee Promthet
Background: There is convincing evidence from epidemiological studies that meat consumption increases colorectal cancer (CRC) risk. However, assessment of any association with a positive fecal immunochemical test (FIT) in CRC screening has been limited. If a link could be shown this might be helpful for establishing a risk group for colonoscopy. Objective: This study aimed to assess any association between meat consumption and other lifestyle factors and a positive FIT result in a Thai population. Methods: A cross-sectional analytical study was conducted with 1,167 participants in a population-based randomized controlled trial...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Reema F Tayyem, Hiba A Bawadi, Ihab Shehadah, Kamal E Bani-Hani, Hamed Takruri, Tareq Al-Jaberi, Dennis D Heath
Background: The effects of consuming fast foods, sweets and beverages on the development of colorectal cancer (CRC) are unclear. The aim of this case-control study was to assess possible associations between the consumption of different fast foods, sweets and beverages and CRC risk in a Jordanian population. Methods: Two hundred and twenty diagnosed CRC cases and 281 controls were enrolled. Diet history was obtained using a validated quantitative questionnaire. Results: Consumption of some types of fast food, and particularly falafel, was associated with an increased risk of developing CRC...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Ananda Giri Babu Alagar, Kadirampatti Mani Ganesh, Karunakaran Kaviarasu
Dose calculation for small field radiotherapy with heterogeneity often involves discrepancies, so that algorithms used by treatment planning systems (TPS) should be evaluated with reference to achieving optimal treatment results. Accuracy of two model based algorithms, AcurosXB (AcXB) and the analytical anisotropic algorithm (AAA) from Eclipse TPS, were here tested. Measurements are made using Gafchromic EBT3 films with indigenously generated lung phantoms irradiated with 6 MV photons. Lung phantoms contained two types of tumor plugs, one kept at an interface attached to the chest wall in right lung (RIT) and the other at the centre of the left lung (LCT)...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Vijayakumar K, Sountharrajan S, Suganya E
Anticancer approaches may employ change of molecular structure to enhance preventive influence of chemical agents. The present examination concerned the potential anticancer impact of modified heterocyclic compounds. A strategy was developed to combine tetrazole moieties from different diamines with 2-aminobenzoic and substituted benzoyl chloride compounds with attention to synthesis, characterization and assessment of cancer preventive activity, applying IR, 1HNMR, 13CNMR and Mass spectra.
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Sadhasivam N, Balamurugan R, Pandi M
Objective: Epigenetic modifications involving DNA methylation and histone statud are responsible for the stable maintenance of cellular phenotypes. Abnormalities may be causally involved in cancer development and therefore could have diagnostic potential. The field of epigenomics refers to all epigenetic modifications implicated in control of gene expression, with a focus on better understanding of human biology in both normal and pathological states. Epigenomics scientific workflow is essentially a data processing pipeline to automate the execution of various genome sequencing operations or tasks...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Porfírio Fernandes de Medeiros Júnior, Eugênio Henrique Vilela Silva, Kelvin Leite Moura, Yasmin Fernandes de Aquino, Mathias Weller
Background: Previous Brazilian studies have indicated that working in agriculture could lead to an increased risk of penile cancer. The present descriptive study aimed at establishing a possible association between penile cancer and agricultural occupation. Materials and methods: Data on a total of 103 penile cancer patients were obtained from medical records of two reference centres for cancer treatment in the state of Paraíba, Northeast Brazil. Information about sexual behaviour was obtained in interviews for 48 cases...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Nigel P Murray, Socrates Aedo, Cynthia Fuentealba, Eduardo Reyes, Anibal Salazar
Introduction: Minimal residual disease (MRD) remaining after curative therapy for prostate cancer has the potential for growth and can result in metastasis. Circulating prostate cells (CPCs) and bone marrow micro-metastasis (mM) could represent different types of MRD. We here determined; biochemical failure free survival rates; time to BF after 10 years follow-up; and the presence of CPCs and mM in patients treated with radical prostatectomy (RP) for prostate cancer. Methods and Patients: One month after RP, blood and bone marrow were sampled for assessment of CPCs and mM...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Tarek Aboushousha, Samah Mamdouh, Hussam Hamdy, Noha Helal, Fatma Khorshed, Gehan Safwat, Mohamed Seleem
Objective: To investigate the expression of TTF-1, RAGE, GLUT1 and SOX2 in HCV-associated HCCs and in surrounding non-tumorous liver tissue. Material and Methods: Tissue material from partial hepatectomy cases for HCC along with corresponding serum samples and 30 control serum samples from healthy volunteers were studied. Biopsies were classified into: non-tumor hepatic tissue (36 sections); HCC (33 sections) and liver cell dysplasia (LCD) (15 sections). All cases were positive for HCV. Immunohistochemistry (IHC), gene extraction and quantitative real-time reverse-transcription assays (qRT-PCR) were applied...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Nur Zaiti Md Arshad, Beng Kwang Ng, Noor Asmaliza Md Paiman, Zaleha Abdullah Mahdy, Rushdan Mohd Noor
Background: Accuracy of diagnosis with intra-operative frozen sections is extremely important in the evaluation of ovarian tumors so that appropriate surgical procedures can be selected. Study design: All patients who with intra-operative frozen sections for ovarian masses in a tertiary center over nine years from June 2008 until April 2017 were reviewed. Frozen section diagnosis and final histopathological reports were compared. Main outcome measures: Sensitivity, specificity, positive and negative predictive values of intra-operative frozen section as compared to final histopathological results for ovarian tumors...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Karim Mashhour, Maha Kamaleldin, Wedad Hashem
Purpose: The aim of this study was to dosimetrically evaluate and compare double arc RapidArc (RA) with conventional IMRT (7 fields) plans for irradiation of locally advanced head and neck cancers (LAHNC), focusing on target coverage and doses received by organs at risk (OAR). Methods: Computed tomography scans of 20 patients with LAHNC were obtained. Contouring of the target volumes and OAR was done. Two plans were made for each patient, one using IMRT and the other double arc RA, and calculated doses to planning target volume (PTV) and OAR were compared...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mervat Alsous, Al-Motassem Yousef, Mariam Abdel Jalil, Mohammed Zawiah, Shorouq Yacoub, Deema Momani, Alia Gharabli, Suha Omar, Rawad Rihani
Background and Aims: It has been demonstrated that homozygote and heterozygote mutant allele carriers for thiopurine S-methyltransferase (TPMT) are at high risk of developing myelosuppression after receiving standard doses of 6-mercaptopurine (6-MP). The aim of this study was to determine the frequency of TPMT deficient alleles in children with acute lymphoblastic leukemia (ALL) in Jordan and to compare it with other ethnic groups. Methods: We included 52 ALL childhood cases from King Hussein Cancer Research Center in Jordan...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Reza Malekpour Afshar, Zeinab Deldar, Hamid Reza Mollaei, Seyed Alimohammad Arabzadeh, Maryam Iranpour
Background: The HPV virus is known to be oncogenic and associations with many cancers has been proven. Although many studies have been conducted on the possible relationship with colorectal cancer (CRC), a definitive role of the virus has yet to be identified. Method: In this cross-sectional study, the frequency of HPV positivity in CRC samples in Kerman was assessed in 84 cases with a mean age of 47.7 ± 12.5 years over two years. Qualitative real time PCR was performed using general primers for the L1 region of HPV DNA...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Yosinta Snak, Indrawati, Kartika Widayati, Nur Arfian, Nungki Anggorowati
Objective: The diffuse large B-cell lymphoma (DLBCL) has two major molecular subtypes, germinal center B-cell-like (GCB) and non-GCB. These have differing behavior which affects overall patient survival. However, immunohistochemistry based molecular subtyping of Indonesian DLBCLs has been limited. This was the focus of the present study, with a focus of attention on the apoptotic index (AI) and the proliferation index (PI) of the two molecular subtypes. Materials and Methods: During the study period of 3.5 years, a total of 98 cases of DLBCL were identified...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
David Oddó, Dahiana Pulgar, Nicole Elgueta, Francisco Acevedo, Dravna Razmiliz, María Elena Navarro, Mauricio Camus, Tomás Merino, Ignacio Retamal, Alejandra Pérez-Sepúlveda, Alejandra Villarroel, Héctor Galindo, José Peña, César Sánchez
Introduction: Breast cancer can be classified into subtypes based on immunohistochemical markers, with Ki67 expression levels being used to divide luminal BC tumors in luminal A and B subtypes; however, Ki67 is not routinely determined due to a lack of standardization. Objective: To evaluate histological grade and Eliminate: the mitotic index to determine if they can be used as an alternative method to Ki67 staining for luminal subtype definition. Methods: We evaluated estrogen receptor positive breast cancer tissue samples...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Caio Cesar Floriano Luz, Juliana Noguti, Leandro Araújo, Thiago Simão Gomes, Gianni Mara, Marcelo De Souza Silva, Ricardo Artigiani Neto
Esophageal cancer is a highly aggressive neoplasm. In Brazil, it is the sixth most frequent among men and fifteenth among women. The most common type is squamous cell carcinoma (SCC), responsible for 96% of cases. Twenty-eight specimens of Esophael squamous cell carcinoma (ESCC) were obtained by surgery procedures.The tissues were fixed in formalin and embedded in paraffin. In each case, all available hematoxylin and eosin stained sections were examined and a representative block was selected. The ages of these patients ranged from 40 to 93 years, with a mean age of 60 years...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Seyed Kazem Mirinezhad, Farideh Mousavi, Masood Baghri, Bita Sepehri, Ali Ghavidel, Morteza Ghojazadeh, Mohammad Hossein Somi
Objective: Familial adenomatous polyposis (FAP), an autosomal dominant inherited disorder is characterized by the presence of multiple adenomatous colorectal polyps, which can develop into cancer during early adulthood. Therefore, early diagnosis is essential. Most FAP patients have several extracolonic manifestations, including congenital hypertrophy of the retinal pigment epithelium (CHRPE). Whereas genetic markers may provide the main route to detection of ‘‘at risk’’ subjects , at present this approach is clearly limited and searches for a noninvasive phenotypic marker continue to be high priority...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Yeni Rahmawati, Yunita Setyawati, Irianiwati Widodo, Ahmad Ghozali, Dewajani Purnomosari
Objective: Breast carcinoma (BC) is a heterogeneous disease that exhibits variation in biological behaviour, prognosis and response to therapy. Molecular classification is generally into Luminal A, Luminal B, HER2+ and triple negative/basal-like, depending on receptor characteristics. Clinical factors that determined the BC prognosis are age and tumor size. Since information on molecular subtypes of Indonesian BCs is limited, the present study was conducted, with attention to subtypes in relation to age and tumor size...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Neha Dahiya, Saurav Basu, Megha Chandra Singh, Suneela Garg, Rajesh Kumar, Charu Kohli
Background: Breast cancer is a major public health problem globally. The ongoing epidemiological, socio-cultural and demographic transition by accentuating the associated risk factors has disproportionately increased the incidence of breast cancer cases and resulting mortality in developing countries like India. Early diagnosis with rapid initiation of treatment reduces breast cancer mortality. Therefore awareness of breast cancer risk and a willingness to undergo screening are essential. The objective of the present study was to assess the knowledge and practices relating to screening for breast cancer among women in Delhi...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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