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Asian Pacific Journal of Cancer Prevention: APJCP

Shabnam Abtahi, Morvarid Asadipour, Abbas Ghaderi
No abstract text is available yet for this article.
September 28, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Farzane Ordoni Aval, Shaghayegh Askarian Amiri, Abbas Azadmehr, Morteza Oladnabi, Payam Saadat, Hadi Ebrahimi, Behzad Baradaran, Behzad Mansoori, Fereshteh Pourabdolhossein, Pedram Torabian, Mahmoud Hajiahmadi
Objective: Glioblastoma (GBM) is the most malignant and aggressive type of glioma, associated with a high rate of mortality. The transforming growth factor-β receptor II (TGFβ RII) is involved in glioma initiation and progression. On the other hand, TGFβ RII silencing is critical to the inhibition of GBM. Therefore, we aimed to determine the effects of specific TGFβ RII siRNA on the survival of U-373MG cells. Methods: TGFβ RII siRNA was transfected, and qRT-PCR was performed to examine TGFβ RII mRNA expression...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Benchapan Panithanang, Wirangrong Srithongklang, Pontip Kompor, Prasit Pengsaa, Natthawut Kaewpitoon, Parichart Wakkhuwattapong, Soraya J Kaewpitoon
This quasi-experimental research aimed to study the effect of health behavior modification program in relation to knowledge, self-efficacy, expectation, and practice for liver fluke prevention among the risk group from Bueng Samrong sub-district, Kaeng Sanam Nang district, Nakhon Ratchasima province, Northeast Thailand. The total of 66 participants was assigned to experimental and comparison group, 33 participants in each group, 12-weeks intervene period. The experimental group was received health behavioral modification programs based on health education, self-efficacy, motivation, social support and networking...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Shenbagavalli P, Thangarajan R
Objective: Breast Cancer is the most invasive disease and fatal disease next to lung cancer in human. Early detection of breast cancer is accomplished by X-ray mammography. Mammography is the most effective and efficient technique used for detection of breast cancer in women and also to improve the breast cancer prognosis. The numbers of images need to be examined by the radiologists, the resulting may be misdiagnosis due to human errors by visual Fatigue. In order to avoid human errors, Computer Aided Diagnosis is implemented...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Shin-Young Lee
Background: Koreans in the Republic of Korea had high incidence and mortality rates of colorectal cancer (CRC), late stage of CRC diagnosis, and low CRC screening. The purpose of this study was to gain a more thorough understanding of CRC awareness, preventive behaviors, and preferred strategies to improve CRC screening behaviors among Koreans. Methods: Individual interviews with 33 Koreans aged 50 and older were conducted using semi-structured, open-ended questions. All interview data were recorded and analyzed using direct content analysis...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Fatemeh Ghaffari, Maryam Bahmanzadeh, Amir Nili-Ahmadabadi, Farzin Firozian
Objective: Paclitaxel (PTX) is a chemotherapeutic agent used for treating breast cancer. The study aimed to prepare PTX loaded dextran stearate (Dex-SA) and evaluate its efficacy against human breast cancer cell line MCF-7. Methods: Dex-SA/PTX micelles were prepared by dialysis method. The micelles size, zeta potential and particle size distribution were measured by dynamic laser light scattering method. Amount of loaded PTX on the polymer measured by HPLC. Release profiles of the drug from the micelles were obtained in buffer (phosphate pH=7...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Wirsma Arif Harahap, Ikhwan R Sudji, Ricvan Dana Nindrea
Objective: The aim of this study was to investigate the BRCA1 promoter methylation and clinicopathological characteristics in sporadic breast cancer patients in Indonesia. Methods: In this cohort study, we selected 90 patients with stage I-III who had definitive surgery at our institution in 2011-2014. Demographic and clinical data regarding pathological stage, breast cancer treatment, outcome etc. were collected from the medical records. Twelve patients had incomplete information on follow up and 18 samples had insufficient tissues for the experiment...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Masumeh Sanaei, Fraidoon Kavoosi, Faeze Dehghani
Background: Phytoestrogens are a group of natural compounds with estrogen-like activity and similar structure to estradiol that structurally mimic the mammalian estrogen 17-β estradiol (E2). They have a biphasic effect and exert pleiotropic effects which induce or inhibit estrogen action by activation/inhibition of the estrogen receptors (ERs). These compounds can induce apoptosis at high concentrations. The previous finding indicated that E2 inhibited cell growth and induced apoptosis in hepatocellular carcinoma (HCC) PLC/PRF/5 cell line...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Neelu Kumari K S, Vijayabaskar S
Objective: This method is to reduce the risk of imprecise diagnosis associated with poor-quality CT images, this paper presents a new technique designed to enhance the quality of medical CT images. The main objective is to improve the appearance of CT images in order to obtain better visual interpretation and analysis, which is expected to ease the diagnosis process. The proposed technique involves applying a deblocking filter is to enhance the visual nature of a picture by diminishing the blocking artifacts...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Songül Budak Diler, Fatma Aybuğa
Background: Urological cancers (prostate cancer and bladder cancers) are the most common cancers in Western population and its rate is increasing in the Eastern World. Autophagy has appeared as a fundamental repair mechanism for degrading damaged organelles and proteins. It was clear that autophagy gene polymorphisms are correlated with development of inflammatory bowel disease and it can also be related with prostate cancer (PCa) or bladder cancer (BCa). In this study, we aimed to determine if ATG16L1 (Thr300Ala) polymorphism is associated with an increased risk of developing PCa and BCa and to establish correlations between ATG16L1 genotypes and morphological parameters...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Samira Sadat Fereidani, Hasan Eini-Zinab, Zeinab Heidari, Saba Jalali, Fatemeh Sedaghat, Bahram Rashidkhani
Objective: To explore the role of nutrient patterns in the etiology of breast cancer (BCa) among Iranian women. Methods: The study included 134 newly diagnosed cases of BCa and 267 hospitalized controls. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess dietary intake. Nutrient patterns were obtained using principal component analysis using Varimax rotation and logistic regression was performed to estimate breast cancer risk. Results: We identified 4 major nutrient patterns...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Supapan Witthayanuwat, Montien Pesee, Chunsri Supaadirek, Narudom Supakalin, Komsan Thamronganantasakul, Srichai Krusun
Introduction: To evaluate the survival of Glioblastoma Multiforme (GBM). Material and Methods: Patients with a pathological diagnosis of Glioblastoma Multiforme (GBM) between 1 January 1994 and 30 November 2013, were retrospectively reviewed. Inclusion criteria: 1) GBM patients with confirmed pathology, 2) GBM patients were treated by multimodality therapy. Exclusion criteria: 1) GBM patients with unconfirmed pathology, 2) GBM patients with spinal involvement, 3) GBM patients with incomplete data records. Seventy-seven patients were treated by multimodality therapy such as surgery plus post-operative radiotherapy (PORT), post-operative Temozolomide (TMZ) concurrent with radiotherapy (CCRT), post-operative CCRT with adjuvant TMZ...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
F M Abu-Duhier, Jamsheed Javid, M A Sughayer, Rashid Mir, Tariq Albalawi, M Shahid Alauddin
Dysregulation in the miRNA-21 expression has been previously observed in a number of malignancies and not only in the tumor cell itself but also in the body fluids of the cancer patients. The present study aimed to find out the clinical significance of cell-free circulating miRNA-21 as an efficient non-invasive biomarker for the screening of lung cancer patients. The present case-control study included plasma samples from 80 lung cancer patients and 80 healthy controls. Magnetic bead technology was used for efficient miRNA isolation and advanced TaqMan miRNA assays were used for the quantification of miRNA-21 level in the plasma of the lung cancer patients and healthy individuals...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mehrdad Ghavifekr Fakhr, Kolsoum Rezaie Kahkhaie, Dariush Shanehbandi, Majid Farshdousti Hagh, Habib Zarredar, Elham Safarzadeh, Mina Abdolrahimi Vind, Behzad Baradaran
Background: In many cases of breast cancer, the aberrant methylation of TP53 gene leads to uncontrolled cell proliferation and apoptosis inhibition. Moreover, expression of oncogenes which are under the control of P53 protein could be altered. Survivin as a conspicuous example of this category plays important roles in tumorigenesis, drug resistance and apoptosis inhibition. The present study was done to reveal the effects of Scrophularia atropatana extract on epigenetic situation of TP53 gene promoter and the expression levels of anti-apoptotic gene, survivin and its potential for production of cancer epi-drugs...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Paulo Furtado de Oliveira, Denise Hollanda Iunes, Ricardo Silva Alves, Jovana Maria de Carvalho, Flávia da Silva Menezes, Leonardo César Carvalho
Objective: In the present study, we aimed to evaluate the effects an exergaming protocol for cancer patients who undergo or have already undergone cancer treatment. We sought to evaluate changes in cancer-related fatigue, function, and ability to perform daily activities, in addition to changes in the electromyographic pattern of the middle deltoid muscle. Methods: We conducted a controlled trial. Nineteen volunteers in the cancer group (aged 61 ± 9 years; body mass index28 ± 5) and 19 in the control group (aged 58 ± 8 years); body mass index 28 ± 4) participated in the study...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
R Mir, I A Al Balawi, F M Abu Duhier
Aim: microRNA-423 is an oncogenic factor which is frequently upregulated in cancer. However, associations with breast cancer risk remain inconsistent. Therefore, we investigated the prevalence of microRNA-423 rs6505162C>T gene variation with breast cancer susceptibility in Saudi women. Methodology: This study was conducted on 100 breast cancer patients and 124 matched healthy individuals. Genotyping of the microRNA-423 rs6505162C/T gene variation was performed by using the amplification refractory mutation system PCR method (ARMS-PCR)...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Morteza Abdoljabbari, Neda Sheikhzakaryaee, Foroozan Atashzadeh- Shoorideh
Background: Due to the rise in prevalence of childhood cancer the impact on family caregivers is increasing. Spirituality may be an alleviating factor for improving the quality of parent life. There is a lack of organized spiritual care in health care facilities, so that this aspect needs more emphasis. Thus this study aimed to evaluate the spiritual strategy of parents of children with cancer. Materials: This qualitative study was conducted with a conventional content analysis approach. Fifteen parents of hospitalized children with cancer at the Oncology and Hematology departments of governmental pediatric hospitals nationwide were purposefully selected...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Albaraa Altowijri, Aladeen Alloubani, Ibrahim Abdulhafiz, Abdulmoneam Saleh
Background: Vitamin D can be obtained through a variety of food sources; however, ultraviolet rays in the sunlight can convert a natural substance in the skin known as ergosterol to vitamin D. Aim: This study aims to investigate the prevalence and risk factors linked to vitamin D deficiency among a group of apparently healthy young male and female Tabuk citizens in Saudi Arabia. Methods: A cross-sectional study that comprised a convenience sampling method of 350 male and female Tabuk citizens. Results: The results indicated a generalized vitamin D deficiency and severe deficiency among the participants, where 74...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Dipu Bharali, Hakim B Jebur, Debabrat Baishya, Suresh Kumar, Manash P Sarma, Mirza Masroor, Juheb Akhter, Syed A Husain, Premashis Kar
Background/objective: HCC is a multistep process starting from chronic hepatitis that progress through cirrhosis to HCC. MicroRNA expression level was found to be deregulated in HCC. To find out whether the expression level of miR-34a and miR-183 was deregulated in HCC compared to controls without HCC. Methods: Real time quantitative PCR was done to find out the miRNA expression level in terms of Ct value followed by statistical analysis. Results: Over-expression of miR-183 and under-expression of miR-34a in HCC was detected...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Neda Bayat, Reza Izadpanah, Somayeh Ebrahimi-Barough, Abbas Norouzi Javidan, Arman Ai, Mohammad Mehdi Mokhtari Ardakan, Hooshang Saberi, Jafar Ai
Purpose: Glioblastoma multiform (GBM) is the most aggressive glial neoplasm. Researchers have exploited the fact that GBMs are highly vascularized tumors. Anti-angiogenic strategies including those targeting VEGF pathway have been emerged for treatment of GBM. Previously, we reported the anti-inflammatory effect of atorvastatin on GBM cells. In this study, we investigated the anti-angiogenesis and apoptotic activity of atorvastatin on GBM cells. Methods: Different concentrations of atorvastatin (1, 5, 10μM) were used on engineered three-dimensional (3D) human tumor models using glioma spheroids and Human Umbilical Vein Endothelial cells (HUVECs) in fibrin gel as tumor models...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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