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Asian Pacific Journal of Cancer Prevention: APJCP

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https://www.readbyqxmd.com/read/28240848/prognostic-significance-of-a-tumor-marker-index-based-on-preoperative-serum-carcinoembryonic-antigen-and-krebs-von-den-lungen-6-levels-in-non-small-cell-lung-cancer
#1
Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Naohiro Nose, Kunihide Nakamura
Background: We retrospectively analysed the prognostic significance of a tumor marker index (TMI) based on preoperative serum carcinoembryonic antigen (CEA) and Krebs von den Lungen-6 (KL-6) levels in nonsmall cell lung cancer (NSCLC) patients. Materials and Methods: We enrolled 176 NSCLC patients who had preoperative serum CEA and KL-6 level measurements and had undergone curative surgery between 2009 and 2011. Results: The 5-year disease-specific survival of patients with high serum CEA levels was significantly poorer compared with that of patients with normal levels...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240847/persian-gulf-jellyfish-cassiopea-andromeda-venom-fractions-induce-selective-injury-and-cytochrome-c-release-in-mitochondria-obtained-from-breast-adenocarcinoma-patients
#2
Mohammad Reza Mirshamsi, Ramesh Omranipour, Amir Vazirizadeh, Amir Fakhri, Fatemeh Zangeneh, Gholam Hussain Mohebbi, Ramin Seyedian, Jalal Pourahmad
Objective: This study was conducted to investigate whether fractions of jellyfish Cassiope andromeda venom, could selectively induce toxicity on mitochondria isolated from cancer tissue of patients with breast adenocarcinomas. Methods: Firstly, we extracted two fractions, (f1 and f2) from crude jellyfish venom by gel filtration on Sephadex G-200.Then different dilutions of these extracted fractions were applied to mitochondria isolated from human breast tumoral- and extra-tumoral tissues. Parameters of mitochondrial toxicity including generation of reactive oxygen species (ROS), mitochondrial membrane potential (MMP) collapse, swelling, cytochrome c release, activation of caspase3 and apoptosis were then assayed...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240846/identification-of-a-low-frequency-missense-variant-in-e2f-transcription-factor-7-associated-with-colorectal-cancer-risk-in-a-chinese-population
#3
Ai Ye Guo, Kan Zhai, Jin Ling Xu, Jin Long Hu, Lan Gao
Background: Transcription factors regulate gene expression and play important role in tumor genesis. Especially, the E2F transcription factor family controls the cell cycle and regulate many tumor suppressors. Missense variants in E2F family genes, which change the amino acid sequence, may alter the capacity for DNA binding or the protein structure, leading to a functional alteration. Material and Methods: We here searched for missense variants in E2F transcription family genes (E2F1~E2F8) and identified two (rs2075995 for E2F2 and rs3829295 for E2F7) with minor allele frequencies >0...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240845/genetic-association-of-xrcc1-gene-rs1799782-rs25487-and-rs25489-polymorphisms-with-risk-of-thyroid-cancer-a-systematic-review-and-meta-analysis
#4
Jamal Jafari Nedooshan, Mohammad Forat Yazdi, Hossein Neamatzadeh, Masoud Zare Shehneh, Saeed Kargar, Niloofar Seddighi
Background: A number of case-control studies have evaluated associations between the X-ray cross complementary group 1 protein (XRCC1) gene rs1799782 (Arg194Trp), rs25487 (Arg399Gln) and rs25489 (Arg280His) polymorphisms and thyroid cancer (TC) risk, but the results remain inconclusive. Materials and Methods: A systematic literature search was performed using PubMed and Google Scholar Search. According to defined criteria data were extracted and pooled odds ratios with 95% confidence intervals were calculated under five genetic models...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240844/diagnostic-value-of-neuron-specific-enolase-nse-and-cancer-antigen-15-3-ca-15-3-in-the-diagnosis-of-pleural-effusions
#5
Mohammad Ali Saba, Toraj Valeh, Hasan Ehteram, Hamed Haddad Kashani, Mahdiyeh Ghazi Zahedi
Introduction: Pleural effusion diagnosis plays an important role in determining treatment strategies. The aim of this study was to determine the diagnostic capacity of tumor markers CA 15-3 and NSE solely or in combination in differentiating the nature of pleural fluid. Methods and Materials: In this cross-sectional study we evaluated 93 patients with pleural effusions (44 malignant and 49 benign). NSE and CA 15-3 serum and pleural levels were measured simultaneously using immunoenzyme assay kits. Diagnosis was established on the basis of cytological study...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240528/novel-mutations-of-the-chrna3-gene-in-non-small-cell-lung-cancer-in-an-iranian-population
#6
Nahid Mehrabi, Seyed Mohammad Moshtaghioun, Hossein Neamatzadeh
Background: Lung cancer, the leading cause of cancer-related worldwide deaths, largely results from the combined effects of smoking exposure and genetic susceptibility. CHRNA3, a nicotinic acetylcholine receptor gene, is associated with lung cancer risk. This study sought to identify variations in exon 3 of CHRNA3 in an Iranian population with non-small cell lung cancer (NSCLC). Materials and methods: A case-control study including 147 individuals with lung cancer and 145 healthy individuals was conducted. As mobility shift caused by nucleotide substitutions might be due to a conformational change of single-stranded DNAs, we designated these as single-strand conformation polymorphisms (SSCPs)...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240527/lack-of-any-association-between-the-hogg1-ser326cys-polymorphism-and-breast-cancer-risk-a-systematic-review-and-meta-analysis-of-18-studies
#7
Mahdieh Kamali, Saeed Kargar, Naeimeh Heiranizadeh, Mohammad Zare, Shadi Kargar, Masoud Zare Shehneh, Hossein Neamatzadeh
Background: The human 8-oxoguanine DNA glycosylase (hOGG1) gene may be linked with cancer susceptibility. The aim of this study was to quantitatively summarize any association between the hOGG1 Ser326Cys polymorphism and breast cancer (BC) risk. Materials and Methods: A comprehensive search of the PubMed, Embase, and ISI web of knowledge databases for papers published before 1 October 2016 was conducted. Summary odds ratios (ORs) with corresponding 95 % confidence intervals (95 %CIs) were estimated, with fixed-effects or random-effects models when appropriate, to assess any association...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240526/expression-changes-of-apoptotic-genes-in-tissues-from-mice-exposed-to-nicotine
#8
Cyrus Jalili, Mohammad Reza Salahshoor, Mohammad Taher Moradi, Maryam Ahookhash, Mehdi Taghadosi, Maryam Sohrabi
Objective: Smoking is the leading preventable cause of various diseases such as lung cancer, chronic obstructive pulmonary disease and cardiovascular disease. Nicotine, one of the major toxic components of tobacco, contributes to the pathogenesis of different diseases. Methods: Given the controversy about nicotine toxicity, the present study was conducted to determine apoptotic effects of nicotine on the heart, kidney, lung and liver of male mice. Real-time PCR was performed to identify mRNA expression changes in apoptotic-related genes between nicotine treated and control mice...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240524/assessment-of-statistical-methodologies-and-pitfalls-of-dissertations-carried-out-at-national-cancer-institute-cairo-university
#9
Rasha M Allam, Maissa K Noaman, Manar M Moneer, Inas A Elattar
Purpose: To identify statistical errors and pitfalls in dissertations performed as part of the requirements for the Medical Doctorate (MD) degree at the National Cancer Institute (NCI), Cairo University (CU) to improve the quality of medical research. Methods: A critical assessment of 62 MD dissertations conducted in 3 departments at NCI, CU, between 2009 and 2013 was carried out regarding statistical methodology and presentation of the results. To detect differences in study characteristics over time, grouping was into two periods; 2009-2010 and 2011-2013...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240523/prognostic-factors-and-survival-of-patients-with-carcinoma-of-the-ampulla-of-vater-after-pancreaticoduodenectomy
#10
Sunhawit Junrungsee, Ekkapope Kittivarakul, Wasana Ko-iam, Worakitti Lapisatepun, Trichak Sandhu, Anon Chotirosniramit
Background: Although carcinoma of the ampulla of Vater (CAV) is a rare tumor, accounting for just 0.2% of gastrointestinal cancers, the survival of CAV patients is unfavorable. The five-year rates have ranged from 36.8-75.2% in previous reports but there is a lack of data relating to Thai people. Also prognostic factors are controversial. Objectives: This study aimed to determine survival outcomes and to identify prognostic factors for a positive outcome for CAV patients after surgery. Methods: In this retrospective cohort study, data were collected from CAV patients who underwent surgery in Chiang Mai University Hospital from 2005 to 2012 for time to event analysis, the log rank test and univariate and multivariate Cox’s regression analysis...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240522/coping-strategies-and-experiences-in-women-with-a-primary-breast-cancer-diagnosis
#11
Sepideh Hajian, Esmat Mehrabi, Masoomeh Simbar, Mohammad Houshyari
Background: Women with breast cancer experience problems in multiple aspects of their lives, but applying effective strategies can result in enhancing their quality of life and their psychosocial adaptation to the disease. However, there is little information about the strategies that women use to cope with complications associated with their experiences following a breast cancer diagnosis. Objectives: The aim of this study was to explore the experience of coping behavior and the main strategies that women use in dealing with a breast cancer diagnosis...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240521/morphological-classification-of-intraductal-papillary-neoplasm-of-the-bile-duct-with-survival-correlation
#12
Vor Luvira, Kulyada Somsap, Ake Pugkhem, Chalerm Eurboonyanun, Varisara Luvira, Vajarabhongsa Bhudhisawasdi, Chawalit Pairojkul, Supot Kamsa Ard
Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a specific entity for which there has been no classification that correlates clinical presentation with patient survival. We, therefore, propose a new classification based on radio-pathological appearance correlated with clinical findings including outcome. Methods: We retrospectively reviewed the medical and pathological records of 103 IPNB patients who underwent curative-intent hepatic resection between January 2008 and December 2011. A morphological classification was then created based on the presence of (a) bile duct dilatation, (b) intraductal mass(es), (c) cystic lesion(s), and (d) macro-invasion of the liver...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240520/roles-of-signal-transducer-pathways-in-investigation-of-biopsies-from-patients-with-bladder-tumors
#13
Aysegul Bayrak, Sukru Palanduz, Ender Coskunpinar, Oner Sanli, Abdullah Armagan, Serkan Karakus, Ramazan Topaktas, Kivanc Cefle, Sukru Ozturk, Ali Ucur
Background:The process of development of bladder cancer features alteration of normal biological conditions caused by changes in molecular pathways. Removing control over regulation of these pathways could lead to changes in signal transduction and abnormal regulation of genes. During tumor formation and progression, genes regulate critical cellular processes, involved in cell cycling, growth and death. Here we evaluated the expression and prognostic importance of FGFR1, HRAS, CCND1, CCND3, STAT3 and FAS genes...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240519/triple-negative-breast-cancer-at-the-university-hospital-mohammed-vi-%C3%A2-oujda
#14
o Al jarroudi, n Abda, Sa Brahmi, S Afqir
Introduction: The triple-negative breast cancer (TNBC), defined by the absence of receptors to oestrogen and progesterone and no histochemical expression of human epidermal receptor -2, is associated with a particularly aggressive behavior. The aim of our study was to determine the clinico-pathological, therapeutic and prognostic features associated with this type of breast cancer in Morocco. Methods: A cohort retrospective study, spread over 3 years, was conducted of 116 breast cancer patients, diagnosed between January 2009 and December 2011 at the Regional Center of Oncology...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240516/transarterial-chemoembolization-combined-with-either-radiofrequency-or-microwave-ablation-in-management-of-hepatocellular-carcinoma
#15
Ashraf Omar Abdelaziz, Ahmed Hosni Abdelmaksoud, Mohamed Mahmoud Nabeel, Hend Ibrahim Shousha, Ahmed Abdelmonem Cordie, Sherif Hamdy Mahmoud, Eman Medhat, Dalia Omran, Tamer Mahmoud Elbaz
Introduction: Local ablative therapy and trans arterial chemoembolization (TACE) are applied to ablate non resectable hepatocellular carcinoma (HCC). Combination of both techniques has proven to be more effective. We aimed to study combined ablation techniques and assess survival benefit comparing TACE with radiofrequency (RFA) versus TACE with microwave (MWA) techniques. Methods: We retrospectively studied 22 patients who were ablated using TACE-RFA and 45 with TACE-MWA. All were classified as Child A-B and lesions did not exceed 5 cm in diameter...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240515/portal-vein-thrombosis-in-unresectable-hcc-cases-a-single-center-study-of-prognostic-factors-and-management-in-140-patients
#16
Ahmed Hosni Abdelmaksoud, Safaa Mandooh, Mohamed Mahmoud Nabeel, Tamer Mahmoud Elbaz, Hend Ibrahim Shousha, Ashraf Monier, Inas Anwar Elattar, Ashraf Omar Abdelaziz
Objective: Hepatocellular carcinoma with portal vein thrombosis is considered a relative contraindication for transarterial chemoembolization (TACE). The aim of our study was to evaluate the prognostic factors and management in patients with hepatocellular carcinoma with portal vein thrombosis (PVT). Methods: Between February 2011 and February 2015, 140 patients presented to our specialized multidisciplinary HCC clinic. All were assessed by imaging at regular intervals for tumor response and the data compared with baseline laboratory and imaging characteristics obtained before treatment...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240514/economic-burden-of-avoidable-hospitalizations-among-patients-with-cancer-at-namazi-hospital-in-shiraz-2013
#17
Nahid Hatam, Tannaz Fanusi, Mehdi Dehghani, Reza Vojdani, Mani Ramzi, Mehrdad Askarian
Introduction: Hospitalization of patients with cancer has a significant economic impact and avoidance where unnecessary has great potential for significant cost savings for patients, individual hospitals and the health system in general. Methods: Demographic, clinical and economical data were collected from medical records in our hospital retrospectively. Oncology clinicians reviewed medical records to categorize each hospitalization as “potentially avoidable” or “not avoidable.” Patient demographic and clinical data were abstracted and quantitative and qualitative analyses were performed to identify patient characteristics and outcomes associated with potentially avoidable hospitalizations...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240513/human-papillomavirus-genotypes-and-methylation-of-cadm1-pax1-mal-and-adcyap1-genes-in-epithelial-ovarian-cancer-patients
#18
Zeinab K Hassan, Mohamed M Hafez, Mahmoud M Kamel, Abdel Rahman N Zekri
Background: High-risk types of human papillomavirus (HR-HPV) may play a role in the development of epithelial ovarian cancer (EOC). The aim of this study was to determine any HPV genotypes and correlations to CADM1, PAX1, MAL and ADCYAP1 gene methylation in Egyptian EOC patients. Materials and methods: The prevalence of HR-HPV in 100 formalin fixed paraffin embedded EOC tissues was determined using nested polymerase chain reaction (PCR) with MY09/MY11 and GP5+/GP6 + primers to amplify a broad spectrum of HPV genotypes in a single reaction...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240512/prediction-of-the-cancer-incidence-in-nepal
#19
Krishna Kanta Poudel, Zhibi Huang, Prakash Raj Neupane, Roberta Steel
Background: The burden of cancer will increase both in males and females in Nepal. Due to the unavailability of a population based cancer registry it is difficult to precisely predict of future incidence rates. However, using hospital-based data to predict the cancer incidence in Nepal it was found that it will certainly increase both in males and females from 2013 to 2020. Material and Methods: For this research we used the cases from the first national cancer registry report (2003) to the cases of the most recent (2012) accumulated by all the hospital based cancer registries in Nepal...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240511/general-breast-cancer-awareness-among-women-in-riyadh-city
#20
Shibl Al Otaibi, Mutaz Al Harbi, Abdulaziz Al Kahmoas, Fahad Al Qhatani, Fahad Al Mutairi, Talal Al Mutairi, Refan Al Ajmi, Fatimah Al Mousawi
Breast cancer is the most common cancer among women globally as well as in Saudi Arabia. Early diagnosis can improve prognosis and breast self-examination (BSE) may be a cost effective way to achieve this. In Saudi Arabia, only a few studies have been conducted to address breast cancer awareness. Most showed a suboptimal level of understanding. During the last few years, Saudi Arabia has established many national campaigns to increase awareness of the disease and facilitate learning about different diagnostic procedures...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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