journal
MENU ▼
Read by QxMD icon Read
search

Genes, Brain, and Behavior

journal
https://www.readbyqxmd.com/read/28211606/nrf2-a-novel-therapeutic-target-in-fragile-x-syndrome-is-modulated-by-nnz2566
#1
Robert M J Deacon, Michael J Hurley, Camila Martínez Rebolledo, Mike Snape, Francisco J Altimiras, Leandro Farías, Michael Pino, Rodolfo Biekofsky, Larry Glass, Patricia Cogram
Fragile X-associated disorders are a family of genetic conditions resulting from the partial or complete loss of fragile X mental retardation protein (FMRP). Among these disorders is fragile X syndrome (FXS), the most common cause of inherited intellectual disability and autism. Progress in basic neuroscience has led to identification of molecular targets for treatment in FXS; however, there is a gap in translation to targeted therapies in humans. The present study introduces a novel therapeutic target for FXS: nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor known to induce expression of over 100 cytoprotective genes...
February 17, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28188958/potassium-channel-gene-associations-with-joint-processing-speed-and-white-matter-impairments-in-schizophrenia
#2
Heather A Bruce, Peter Kochunov, Sara A Paciga, Craig L Hyde, Xing Chen, Zhiyong Xie, Baohong Zhang, Hualin S Xi, Patricio O'Donnell, Christopher Whelan, Christian R Schubert, Alfredo Bellon, Seth A Ament, Dinesh K Shukla, Xiaoming Du, Laura M Rowland, Hugh O'Neill, L Elliot Hong
Patients with schizophrenia show decreased processing speed on neuropsychological testing and decreased white matter integrity as measured by diffusion tensor imaging, two traits shown to be both heritable and genetically associated indicating that there may be genes that influence both traits as well as schizophrenia disease risk. The potassium channel gene family is a reasonable candidate to harbor such a gene given the prominent role potassium channels play in the central nervous system in signal transduction, particularly in myelinated axons...
February 11, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28186690/reduced-levels-of-cacna1c-attenuate-mesolimbic-dopamine-system-function
#3
Chantelle E Terrillion, David T Dao, Roger Cachope, Mary Kay Lobo, Adam C Puche, Joseph F Cheer, Todd D Gould
Genetic variation in CACNA1C, which codes for the L-type calcium channel (LTCC) Cav 1.2, is associated with clinical diagnoses of bipolar disorder, depression, and schizophrenia. Dysregulation of the mesolimbic dopamine (DA) system is linked to these syndromes and LTCCs are required for normal DAergic neurotransmission between the ventral tegmental area (VTA) and nucleus accumbens (NAc). It is unclear, however, how variations in CACNA1C genotype, and potential subsequent changes in expression levels in these regions, modify risk...
February 10, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28160436/role-of-the-mt1-and-mt2-melatonin-receptors-in-mediating-depressive-and-anxiety-like-behaviors-in-c3h-hen-mice
#4
Jiabei Liu, Shannon J Clough, Margarita L Dubocovich
Melatonin is a neuro-hormone primarily synthesized by the pineal gland following a circadian rhythm with a high level during the night and a low level during the day. Alterations in the synthesis and secretion of melatonin have been reported in various mood disorders, including major depressive disorder. However, the role of endogenous melatonin in the pathophysiology of depressive disorder is unclear. Melatonin primarily acts through two G protein-coupled receptors, termed MT1 and MT2. The present study investigated the effect of genetic deletion of the MT1 and/or MT2 receptors on tests associated with depression-like and anxiety-like behaviors in C3H/HeN mice...
February 3, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28133939/reduced-acoustic-startle-response-and-peripheral-hearing-loss-in-the-5xfad-mouse-model-of-alzheimer-s-disease
#5
Timothy P O'Leary, Sooyoun Shin, Emre Fertan, Rachel N Dingle, Awad Almuklass, Rhian K Gunn, Zhiping Yu, Jian Wang, Richard E Brown
Hearing dysfunction has been associated with Alzheimer's disease in humans, but there is little data on the auditory function of mouse models of Alzheimer's disease. Furthermore, characterization of hearing ability in mouse models is needed to ensure that tests of cognition that use auditory stimuli are not confounded by hearing dysfunction. Therefore we assessed acoustic startle response and pre-pulse inhibition in the double transgenic 5xFAD mouse model of Alzheimer's disease from 3-4 to 16 months of age...
January 29, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28067462/association-of-akap6-and-mir2113-with-cognitive-performance-in-a-population-based-sample-of-older-adults
#6
Shea J Andrews, Debjani Das, Kaarin J Anstey, Simon Easteal
Genetic factors make a substantial contribution to inter-individual variability in cognitive function. A recent meta-analysis of genome-wide association studies identified two loci, AKAP6 and MIR2113, that are associated with general cognitive function. Here, we extend this previous research by investigating the association of MIR2113 and AKAP6 with baseline and longitudinal nonlinear change across a broad spectrum of cognitive domains in community-based cohort of older adults without dementia. Two SNPs, MIR211-rs10457441 and AKAP6-rs17522122 were genotyped in 1,570 non-demented older Australians of European ancestry, who were examined up to 4 times over 12 years...
January 9, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28058793/effects-of-selection-for-ethanol-preference-on-gene-expression-in-the-nucleus-accumbens-of-hs-cc-mice
#7
A M Colville, O D Iancu, D L Oberbeck, P Darakjian, C L Zheng, N A R Walter, C A Harrington, R P Searles, S McWeeney, R J Hitzemann
Previous studies on changes in murine brain gene expression associated with the selection for ethanol preference have used F2 intercross or heterogeneous stock (HS) founders, derived from standard laboratory strains. However, these populations represent only a small proportion of the genetic variance available in Mus musculus. To investigate a wider range of genetic diversity, we selected mice for ethanol preference using an HS derived from the eight strains of the collaborative cross. These HS mice were selectively bred (four generations) for high and low ethanol preference...
January 6, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28009101/bdnf-val66met-polymorphism-moderates-the-link-between-child-maltreatment-and-reappraisal-ability
#8
Andrei C Miu, Mihai Cărnuță, Romana Vulturar, Raluca D Szekely-Copîndean, Mirela I Bîlc, Adina Chiș, Marius Cioară, Katya C Fernandez, Aurora Szentágotai-Tătar, James J Gross
Child maltreatment is associated with increased risk for virtually all common mental disorders, but it is not yet clear why. One possible mechanism is emotion regulation ability. The present study investigated for the first time the influence of a BDNF Val66Met genotype × child maltreatment interaction on emotion regulation, and compared differential susceptibility and diathesis-stress models. A sample of N = 254 healthy volunteers were genotyped for the BDNF Val66Met polymorphism and underwent an experimental assessment of reappraisal ability (i...
December 23, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28000999/n-ofq-system-in-brain-areas-of-nerve-injured-mice-its-role-in-different-aspects-of-neuropathic-pain
#9
M Palmisano, D Mercatelli, F F Caputi, D Carretta, P Romualdi, S Candeletti
Several studies showed that chronic pain causes reorganization and functional alterations of supraspinal brain regions. The nociceptin-NOP receptor system is one of the major systems involved in pain control and much evidence also suggested its implication in stress, anxiety and depression. Therefore, we investigated the nociceptin-NOP system alterations in selected brain regions in a neuropathic pain murine model. Fourteen days after the common sciatic nerve ligature, PCR analysis indicated a significant decrease of pronociceptin and NOP receptor mRNA levels in the thalamus; these alterations could contribute to the decrease of the thalamic inhibitory function reported in neuropathic pain condition...
December 21, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27886459/standardised-experiments-in-mutant-mice-reveal-behavioural-similarity-on-129s5-and-c57bl-6j-backgrounds
#10
Louie N van de Lagemaat, Lianne E Stanford, Charles Pettit, Douglas J Strathdee, Karen E Strathdee, Kathryn A Elsegood, David G Fricker, Mike D R Croning, Noboru H Komiyama, Seth G N Grant
Behavioural analysis of mice carrying engineered mutations is widely used to identify roles of specific genes in components of the mammalian behavioural repertoire. The reproducibility and robustness of phenotypic measures has become a concern that undermines the use of mouse genetic models for translational studies. Contributing factors include low individual study power, non-standardised behavioural testing, failure to address confounds and differences in genetic background of mutant mice. We have examined the importance of these factors using a statistically robust approach applied to behavioural data obtained from three mouse mutations on 129S5 and C57BL/6J backgrounds generated in a standardised battery of five behavioural assays...
November 25, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27643807/muscle-spindle-alterations-precede-onset-of-sensorimotor-deficits-in-charcot-marie-tooth-type-2e
#11
E Villalón, M R Jones, C Sibigtroth, S J Zino, J M Dale, D S Landayan, H Shen, D D W Cornelison, M L Garcia
Charcot-Marie-Tooth (CMT) is the most common inherited peripheral neuropathy, affecting approximately 2.8 million people. The CMT leads to distal neuropathy that is characterized by reduced motor nerve conduction velocity, ataxia, muscle atrophy and sensory loss. We generated a mouse model of CMT type 2E (CMT2E) expressing human neurofilament light E396K (hNF-L(E396K) ), which develops decreased motor nerve conduction velocity, ataxia and muscle atrophy by 4 months of age. Symptomatic hNF-L(E396K) mice developed phenotypes that were consistent with proprioceptive sensory defects as well as reduced sensitivity to mechanical stimulation, while thermal sensitivity and auditory brainstem responses were unaltered...
February 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27594048/a-heterozygous-mutation-in-tubulin-beta-2b-tubb2b-causes-cognitive-deficits-and-hippocampal-disorganization
#12
Rolf W Stottmann, Ashley Driver, Arnold Gutierrez, Matthew R Skelton, Michael Muntifering, Christopher Stepien, Luke Knudson, Matthew Kofron, Charles V Vorhees, Michael T Williams
Development of the mammalian forebrain requires a significant contribution from tubulin proteins to physically facilitate both the large number of mitoses in the neurogenic brain (in the form of mitotic spindles) as well as support cellular scaffolds to guide radial migration (radial glial neuroblasts). Recent studies have identified a number of mutations in human tubulin genes affecting the forebrain, including TUBB2B . We previously identified a mouse mutation in Tubb2b and we show here that mice heterozygous for this missense mutation in Tubb2b have significant cognitive defects in spatial learning and memory...
February 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27581946/variation-in-mothers-arginine-vasopressin-receptor-1a-and-dopamine-receptor-d4-genes-predicts-maternal-sensitivity-via-social-cognition
#13
E M Leerkes, J Su, S Calkins, V C Henrich, A Smolen
We examined the extent to which the arginine vasopressin receptor 1a (AVPR1a) and dopamine receptor D4 (DRD4) were related to sensitive maternal behavior directly or indirectly via maternal social cognition. Participants were 207 (105 European-American and 102 African-American) mothers and their children (52% females). Sensitive maternal behavior was rated and aggregated across a series of tasks when infants were 6 months, 1 year and 2 years old. At 6 months, mothers were interviewed about their empathy, attributions about infant behavior and beliefs about crying to assess their parenting-related social cognition...
February 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28097813/drug-addictions-new-insight-into-causes-comorbidity-and-potential-treatments
#14
EDITORIAL
Andrew Holmes
No abstract text is available yet for this article.
January 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27906494/alcohol-dependent-molecular-adaptations-of-the-nmda-receptor-system
#15
REVIEW
N Morisot, D Ron
Phenotypes such as motivation to consume alcohol, goal-directed alcohol seeking and habit formation take part in mechanisms underlying heavy alcohol use. Learning and memory processes greatly contribute to the establishment and maintenance of these behavioral phenotypes. The N-methyl-d-aspartate receptor (NMDAR) is a driving force of synaptic plasticity, a key cellular hallmark of learning and memory. Here, we describe data in rodents and humans linking signaling molecules that center around the NMDARs, and behaviors associated with the development and/or maintenance of alcohol use disorder (AUD)...
January 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27860248/restructuring-of-basal-ganglia-circuitry-and-associated-behaviors-triggered-by-low-striatal-d2-receptor-expression-implications-for-substance-use-disorders
#16
REVIEW
L K Dobbs, J C Lemos, V A Alvarez
Dopamine D2 receptors (D2Rs) consistently emerge as a critical substrate for the etiology of some major psychiatric disorders. Indeed, a central theory of substance use disorders (SUDs) postulates that a reduction in D2R levels in the striatum is a determining factor that confers vulnerability to abuse substances. A large number of clinical and preclinical studies strongly support this link between SUDs and D2Rs; however, identifying the mechanism by which low D2Rs facilitate SUDs has been hindered by the complexity of circuit connectivity, the heterogeneity of D2R expression and the multifaceted constellation of phenotypes observed in SUD patient...
January 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27749004/neurobiology-of-comorbid-post-traumatic-stress-disorder-and-alcohol-use-disorder
#17
REVIEW
N W Gilpin, J L Weiner
Post-traumatic stress disorder (PTSD) and alcohol-use disorder (AUD) are highly comorbid in humans. Although we have some understanding of the structural and functional brain changes that define each of these disorders, and how those changes contribute to the behavioral symptoms that define them, little is known about the neurobiology of comorbid PTSD and AUD, which may be due in part to a scarcity of adequate animal models for examining this research question. The goal of this review is to summarize the current state-of-the-science on comorbid PTSD and AUD...
January 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27706932/do-specific-nmda-receptor-subunits-act-as-gateways-for-addictive-behaviors
#18
REVIEW
F W Hopf
Addiction to alcohol and drugs is a major social and economic problem, and there is considerable interest in understanding the molecular mechanisms that promote addictive drives. A number of proteins have been identified that contribute to expression of addictive behaviors. NMDA receptors (NMDARs), a subclass of ionotropic glutamate receptors, have been of particular interest because their physiological properties make them an attractive candidate for gating induction of synaptic plasticity, a molecular change thought to mediate learning and memory...
January 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27657733/reprogramming-of-mpfc-transcriptome-and-function-in-alcohol-dependence
#19
REVIEW
M Heilig, E Barbier, A L Johnstone, J Tapocik, M W Meinhardt, S Pfarr, C Wahlestedt, W H Sommer
Despite its limited immediate reinforcement value, alcohol has a potent ability to induce neuroadaptations that promote its incentive salience, escalation of voluntary alcohol intake and aversion-resistant alcohol seeking. A constellation of these traits, collectively called 'post-dependent', emerges following brain exposure to repeated cycles of intoxication and withdrawal. The medial prefrontal cortex (mPFC) and its subdivisions exert top-down regulation of approach and avoidance behaviors, including those that lead to alcohol intake...
January 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27621103/preclinical-voluntary-drinking-models-for-alcohol-abstinence-induced-affective-disturbances-in-mice
#20
REVIEW
K M Holleran, D G Winder
Negative reinforcement is widely thought to play an important role in chronic alcohol-use disorders (AUDs), and high comorbidity between AUDs and affective disorders highlights the importance of investigating this relationship. Prominent models posit that repeated cycles of alcohol (ethanol, EtOH) exposure and withdrawal produce circuit adaptations in the central nervous system that drive a transition from positive- to negative reinforcement-based alcohol seeking. Evidence supporting this theory has accumulated in large part using forced EtOH administration models, such as chronic intragastric gavage and chronic vapor inhalation...
January 2017: Genes, Brain, and Behavior
journal
journal
39878
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"