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Autoimmunity Reviews

journal
https://www.readbyqxmd.com/read/30217550/neutrophils-novel-key-players-in-rheumatoid-arthritis-current-and-future-therapeutic-targets
#1
REVIEW
Irene Cecchi, Ivan Arias de la Rosa, Elisa Menegatti, Dario Roccatello, Eduardo Collantes-Estevez, Chary Lopez-Pedrera, Nuria Barbarroja
Rheumatoid Arthritis (RA) is a complex systemic autoimmune disease in which various cell types are involved. Among them, neutrophils have been recognized as important players in the onset and the progression of RA. The pathogenic role of neutrophils in RA lies in the alteration of several processes, including increased cell survival and migratory capacity, abnormal inflammatory activity, elevated oxidative stress and an exacerbated release of neutrophil extracellular traps. Through these mechanisms, neutrophils can activate other immune cells, thus perpetuating inflammation and leading to the destruction of the cartilage and bone of the affected joint...
September 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30217549/giant-cell-arteritis-and-inflammatory-bowel-disease-is-there-a-connection-results-from-a-population-based-study
#2
REVIEW
Yarden Yavne, Shmuel Tiosano, Dana Ben-Ami, Abdulla Watad, Adi Guy, Doron Comaneshter, Arnon D Cohen, Howard Amital
BACKGROUND: Giant cell arteritis (GCA) is an autoimmune disorder which primarily affects large vessels, whilst inflammatory bowel diseases (IBD) mainly target the gut. Co-existence of the two maladies has been reported sporadically in the literature; therefore the purpose of this study was to assess the authenticity of such an association in a large, cross-sectional study. METHODS: Utilizing data derived from the Clalit Health Services' registry, the largest health maintenance organization in Israel, we compared the proportion of CD and UC in GCA patients with age- and gender-matched controls...
September 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213700/mechanistic-immunological-based-classification-of-rheumatoid-arthritis
#3
REVIEW
Dennis McGonagle, Abdulla Watad, Sinisa Savic
The classical autoimmunity paradigm in rheumatoid arthritis (RA) is strongly supported by immunogenetics suggesting follicular helper T-cell responses driving high titre specific autoantibodies that pre-dates disease onset. Using the immunological disease continuum model of inflammation against self with "pure" adaptive and innate immune disease at opposite boundaries, we propose a novel immune mechanistic classification describing the heterogeneity within RA. Mutations or SNPs in autoinflammatory genes including MEFV and NOD2 are linked to seronegative RA phenotypes including some so called palindromic RA cases...
September 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213699/the-role-of-dietary-sodium-on-autoimmune-diseases-the-salty-truth
#4
REVIEW
Kassem Sharif, Howard Amital, Yehuda Shoenfeld
Autoimmune diseases are a group of heterogeneous condition that occur secondary to the intrinsic loss of tolerance to self- antigens. In genetically susceptible individuals, the complex interplay of environmental factors and epigenetic deregulations have been proposed to drive disease etiopathogenesis. Various environmental variables have been identified including viral infections, exposure to pollutants, stress and dietary factors. Sodium, a major constituent of salt is essential for mammalian physiology. However, high salt intake may play a role in the development of autoimmune diseases...
September 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213698/probiotics-and-autoimmunity-current-evidence
#5
LETTER
Oded Shamriz
No abstract text is available yet for this article.
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213697/food-intolerance-in-patients-with-manifest-autoimmunity-observational-study
#6
REVIEW
Francis Coucke
In the professional medical and scientific world, there is not many interest in the correlation of food intolerance and autoimmune diseases. However there is a lot of evidence that e.g. gluten or gliadine can induce autoimmmune diseases: example the interest in coeliac disease and autoimmunity. There is however a lot of informationavailable about leaky gut and autoimmunity. We performed an observational study in our data base;, where we selected 100 patients with manifest autoimmune disease with clear symptoms and autoimmune antibodies in the form of positive anf more tehn 160 titer...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213696/autoimmune-hunger-games-a-brief-outline-of-the-expanding-role-of-nutrition-in-the-aggravation-and-attenuation-of-autoimmune-and-rheumatic-diseases
#7
REVIEW
Yahel Segal
No abstract text is available yet for this article.
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213695/are-we-really-what-we-eat-nutrition-and-its-role-in-the-onset-of-rheumatoid-arthritis
#8
REVIEW
Elena Philippou, Elena Nikiphorou
Accumulating research evidence suggests that individual dietary factors and dietary patterns might be implicated in the risk of development of rheumatoid arthritis (RA). This narrative review aims to present this evidence and provide nutritional recommendations for reducing RA risk in susceptible individuals. Overall, a 'Western' type diet rich in energy intake, total and saturated fat, an unbalanced ratio of n-3 to n-6 fatty acids, high in refined carbohydrates and sugar and low in fiber and antioxidants might increase the risk of RA both directly through increasing inflammation and indirectly through increasing insulin resistance and obesity, with the latter being a known risk factor for RA...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213694/osteoarthritis-and-its-management-epidemiology-nutritional-aspects-and-environmental-factors
#9
REVIEW
Alessandra Bortoluzzi, Federica Furini, Carlo A Scirè
Osteoarthritis (OA) is the most prevalent chronic rheumatic diseases worldwide, with a strong impact on individual and population health. OA is a clinically heterogeneous disease presenting with different clinical phenotypes recognising systemic and local risk factors. The pathogenesis is multifactorial including constitutive features of the joint, non-modifiable and modifiable risk factors. Epidemiological studies highlight the link between metabolic syndrome and OA and the effect of interplay between immunological and metabolic processes is getting increasing emphasis because of to the discovery that metabolic syndrome is implicated in OA pathogenesis and progression...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213693/impact-of-micronutrient-deficiency-malnutrition-in-systemic-sclerosis-cohort-study-and-literature-review
#10
REVIEW
Romain Dupont, Mélanie Longué, Anne Galinier, Christel Cinq Frais, Cécile Ingueneau, Léonardo Astudillo, Philippe Arlet, Daniel Adoue, Laurent Alric, Grégoire Prévot, Bastien Cabarrou, Laurent Sailler, Grégory Pugnet
OBJECTIVES: The purpose of our study was to determine the prevalence and risk factors associated with malnutrition, and selenium (Se) and vitamin C (vitC) deficiencies in systemic sclerosis (SSc) patients. METHODS: We included adult SSc patients fulfilling the 2013 ACR/EULAR criteria from the Toulouse University Hospital cohort who underwent a micronutrient workup (including vitC, Se or thiamine levels) between 2011 and 2016. RESULTS: 82 patients were included, mostly women (76%), with a median age of 60 years...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213692/nutritional-recommendations-for-gout-an-update-from-clinical-epidemiology
#11
REVIEW
Sabrina Mai Nielsen, Kristian Zobbe, Lars Erik Kristensen, Robin Christensen
OBJECTIVE: To present the evidence for nutritional lifestyle changes recommended for gout patients; an explicit focus will be on the evidence for weight loss in overweight gout patients based on a recent systematic review and to describe methodological details for a coming weight loss trial. METHODS: We did a pragmatic but systematic search in MEDLINE for current guidelines that had made an attempt to make nutritional recommendations for gout. The quality of the evidence for the nutritional recommendations was evaluated based on the guidelines' own ratings and converted into a common simple version based on the GRADE system...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213691/how-can-autoantibodies-predict-the-long-term-outcome-of-patients-with-interstitial-lung-disease-results-from-a-retrospective-cohort-study
#12
REVIEW
Christos F Kampolis, Aliki I Venetsanopoulou, Foteini Karakontaki, Vlasis Polychronopoulos, Panayiotis Vlachoyiannopoulos, Athanasios G Tzioufas
OBJECTIVES: This study aimed to investigate whether positive serum autoantibodies (AAbs) have any impact on survival and time evolution of radiological findings and pulmonary function indices in patients with interstitial lung disease (ILD). PATIENTS AND METHODS: Ninety four patients with regular clinical, functional and high resolution computed tomography (HRCT) imaging follow-up for at least 12 consecutive months and complete testing for a panel of AAbs most commonly associated with ILD were enrolled in this retrospective two-center study...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30213690/the-mediterranean-diet-fish-oil-supplements-and-rheumatoid-arthritis-outcomes-evidence-from-clinical-trials
#13
REVIEW
Sara Petersson, Elena Philippou, Carrie Rodomar, Elena Nikiphorou
The impact of dietary interventions such as specific types of diet or nutritional supplements in rheumatoid arthritis (RA) has been subject to increased attention in recent years. The recognition of the unmet need to better understand the effects of specific dietary interventions on disease outcomes in RA, along with the growing patient interest on lifestyle interventions beyond pharmacotherapy, have informed the undertaking of this narrative literature review. The benefits of the Mediterranean Diet (MD) have been shown in various studies, although only a limited number of trials focus specifically on RA...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30118900/the-role-of-stress-in-the-mosaic-of-autoimmunity-an-overlooked-association
#14
REVIEW
Kassem Sharif, Abdulla Watad, Louis Coplan, Benjamin Lichtbroun, Alec Krosser, Michael Lichtbroun, Nicola Luigi Bragazzi, Howard Amital, Arnon Afek, Yehuda Shoenfeld
Stress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which occur secondary to loss of self antigen tolerance. The etiopathogenesis of autoimmune disease is uncertain. Genetic factors as well as environmental factors appear to interplay, leading to a cascade of events resulting in disease onset...
October 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30118899/antiphospholipid-syndrome-an-update-on-risk-factors-for-pregnancy-outcome
#15
REVIEW
Sara De Carolis, Sara Tabacco, Francesca Rizzo, Andrea Giannini, Angela Botta, Silvia Salvi, Cristina Garufi, Pierluigi Benedetti Panici, Antonio Lanzone
BACKGROUND: The optimal treatment of women with primary antiphospholipid syndrome (APS) is still debated. About 20-30% of women with APS remain unable to give birth to healthy neonates despite conventional treatment, consisting of prophylactic-dose heparin and low-dose aspirin. These cases are defined "refractory obstetric APS". The early identification of risk factors associated with poor pregnancy outcome could be the optimal strategy to establish criteria for additional therapies, such as hydroxychloroquine, steroids, intravenous immunoglobulin, and plasma exchange...
October 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30114520/childhood-versus-adult-onset-polyarteritis-nodosa-results-from-the-french-vasculitis-study-group-registry
#16
REVIEW
Michele Iudici, Pierre Quartier, Christian Pagnoux, Etienne Merlin, Christian Agard, Achille Aouba, Pascal Roblot, Pascal Cohen, Benjamin Terrier, Luc Mouthon, Loïc Guillevin, Xavier Puéchal
OBJECTIVE: To investigate differences between childhood (cPAN)- and adult-onset polyarteritis nodosa (aPAN) patients. METHODS: cPAN patients' clinical findings at onset and outcomes were compared to those of aPAN patients from the French Vasculitis Study Group registry matched for year of enrollment and initial systemic versus cutaneous disease. Their information on medications, disease activity and damage were collected. Kaplan-Meier relapse-free survival curves and the log-rank test were used to analyze cPAN versus aPAN differences for predefined outcomes...
October 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30107267/does-cyclophosphamide-still-play-a-role-in-glomerular-diseases
#17
REVIEW
Claudio Ponticelli, Rachele Escoli, Gabriella Moroni
Cyclophosphamide is a prodrug that is converted to inactive carboxy-cyclophosphamide, acrolein and phosphoramide mustard, an agent that adds alkyl groups to oxygen and nitrogen atoms of guanine, one of the four nitrogen bases that form the DNA nucleotides, causing DNA cross-links and introducing DNA breaks. These cytotoxic and mutagenic effects mainly occur in proliferating cells. Repair mechanisms may prevent DNA damage in quiescent cells, but they may be insufficient to contrast the side effects of cyclophosphamide if high doses of the drug are used...
October 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30107266/monogenic-polyautoimmunity-in-primary-immunodeficiency-diseases
#18
REVIEW
Gholamreza Azizi, Reza Yazdani, Wiliam Rae, Hassan Abolhassani, Manuel Rojas, Asghar Aghamohammadi, Juan-Manuel Anaya
Primary immunodeficiency diseases (PIDs) consist of a large group of genetic disorders that affect distinct components of the immune system. PID patients are susceptible to infection and non-infectious complications, particularly autoimmunity. A specific group of monogenic PIDs are due to mutations in genes that are critical for the regulation of immunological tolerance and immune responses. This group of monogenic PIDs is at high risk of developing polyautoimmunity (i.e., the presence of more than one autoimmune disease in a single patient) because of their impaired immunity...
October 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30107265/the-link-between-immunity-autoimmunity-and-endometriosis-a-literature-update
#19
REVIEW
Tao Zhang, Caterina De Carolis, Gene Chi Wai Man, Chi Chiu Wang
Endometriosis (EMS), an estrogen-dependent inflammatory disorder affects approximately 5-10% of the general female population of reproductive age and 20-90% of women with pelvic pain and infertility. Many immunological factors are known to contribute significantly to the pathogenesis and pathophysiology of EMS, and both chronic local inflammation and autoantibodies in EMS shares many similarities with autoimmune diseases (AD). However, the autoimmune etiology in EMS remains controversial, and its evidence on autoimmune basis may be limited...
October 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30103047/new-insights-into-the-etiopathogenesis-of-hashimoto-s-thyroiditis-the-role-of-genetics-and-epigenetics
#20
LETTER
Massimo Ralli, Armando De Virgilio, Marco Artico, Lucia Longo, Marco de Vincentiis, Antonio Greco
No abstract text is available yet for this article.
October 2018: Autoimmunity Reviews
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