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Autoimmunity Reviews

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https://www.readbyqxmd.com/read/30009962/antibodies-targeting-circulating-protective-molecules-in-lupus-nephritis-interest-as-serological-biomarkers
#1
REVIEW
Chantal Dumestre-Pérard, Giovanna Clavarino, Sophie Colliard, Jean-Yves Cesbron, Nicole M Thielens
Lupus nephritis (LN) is one of the most frequent and severe manifestations of systemic lupus erythematosus (SLE), considered as the major predictor of poor prognosis. An early diagnosis of LN is a real challenge in the management of SLE and has an important implication in guiding treatments. In clinical practice, conventional parameters still lack sensitivity and specificity for detecting ongoing disease activity in lupus kidneys and early relapse of nephritis. LN is characterized by glomerular kidney injury, essentially due to deposition of immune complexes involving autoantibodies against cellular components and circulating proteins...
July 13, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30009963/vimentin-as-antigenic-target-in-autoimmunity-a-comprehensive-review
#2
REVIEW
Aram Musaelyan, Sergey Lapin, Vladimir Nazarov, Olga Tkachenko, Boris Gilburd, Alexandra Mazing, Lilia Mikhailova, Yehuda Shoenfeld
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis...
July 12, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30007856/acpa-mediates-the-interplay-between-innate-and-adaptive-immunity-in-rheumatoid-arthritis
#3
REVIEW
Xiwen Dong, Zhaohui Zheng, Yue Zhai, Yan Zheng, Jin Ding, Jianli Jiang, Ping Zhu
The production of anti-citrullinated peptide antibodies (ACPAs) requires the participation of both innate immunity and adaptive immunity. On the one hand, activated innate immunity is able to produce citrullinated auto-antigens that fuel autoimmunity and provide an inflammatory environment that facilitates the breach of self-tolerance, proliferation of self-reactive T/B cells and the production of ACPAs. On the other hand, after their production by plasma B cells, ACPAs are also able to interact with innate immunity to exacerbate the manifestation and chronicity of rheumatoid arthritis (RA)...
July 11, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005862/pathogenic-role-of-tissue-resident-memory-t-cells-in-autoimmune-diseases
#4
REVIEW
Haijing Wu, Wei Liao, Qianwen Li, Hai Long, Heng Yin, Ming Zhao, Vera Chan, Chak-Sing Lau, Qianjin Lu
The tissue-resident memory T (TRM ) cells constitute a newly identified subset of memory T cells which are non-circulating and they persist for long-term in epithelial barrier tissues, including skin, lung, gastrointestinal tract and reproductive tract, and in non-barrier tissues, including brain, kidney, pancreas and joint. These cells provide rapid on-site immune protection against previous exposed pathogens in peripheral tissues. There cells are transcriptionally, functionally and phenotypically distinguished from circulating effector memory T cells...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005861/support-of-precision-medicine-through-risk-stratification-in-autoimmune-liver-diseases-histology-scoring-systems-and-non-invasive-markers
#5
REVIEW
Lars Bossen, Alessio Gerussi, Vasiliki Lygoura, George F Mells, Marco Carbone, Pietro Invernizzi
Autoimmune liver diseases (AILDs) are complex conditions, which arise from the interaction between a genetic susceptibility and unknown environmental triggers. They represent a relevant cause of liver failure and liver transplantation worldwide. As a testimony of our progress in understanding the biology of AILDs and the disease progression is the overall median survival which has increased over the last decade. However, there are still major challenges such as the lack of therapies and surveillance strategies in primary sclerosing cholangitis (PSC), the management and treatment of non-responders to first-line therapies in primary biliary cholangitis (PBC) and the need for tailoring immunosuppressive drugs in autoimmune hepatitis (AIH)...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005860/therapy-of-scleroderma-renal-crisis-state-of-the-art
#6
REVIEW
Elisabetta Zanatta, Pamela Polito, Mariangela Favaro, Maddalena Larosa, Piero Marson, Franco Cozzi, Andrea Doria
Scleroderma renal crisis (SRC) is an uncommon but still life-threatening manifestation of systemic sclerosis (SSc). The incidence of SRC has decreased in the last few decades, probably due to a widespread use of vasodilators in SSc patients. It is well-recognized that exposure to different drugs can trigger SRC (corticosteroids, cyclosporine) or prevent its occurrence (iloprost, calcium channel blockers). The prognosis of this life-threatening manifestation has not substantially improved since 1980s, when ACE-inhibitors were introduced in its treatment...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005859/classification-of-primary-antiphospholipid-syndrome-as-systemic-lupus-erythematosus-analysis-of-a-cohort-of-214-patients
#7
REVIEW
Romain Paule, Nathalie Morel, Véronique Le Guern, Micaela Fredi, Laetitia Coutte, Meriem Belhocine, Luc Mouthon, Claire le Jeunne, Anthony Chauvin, Jean-Charles Piette, Nathalie Costedoat-Chalumeau
OBJECTIVES: To assess the limitations of the SLICC (Systemic Lupus International Collaborating Clinics) classification criteria for systemic lupus erythematosus (SLE), in patients with primary antiphospholipid syndrome (PAPS). METHODS: Retrospective study of a cohort of APS patients (Sydney criteria). We successively excluded patients with (1) at least one "SLE-specific" manifestation (biopsy-proven SLE nephropathy, arthritis, cutaneous, or neurologic SLE manifestations, pericarditis, autoimmune haemolytic anaemia, oral and nasal ulcers, non-scarring alopecia, anti-dsDNA, and anti-Sm antibodies), (2) any other autoimmune connective tissue disease, and/or (3) antinuclear antibodies >1/320...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005858/subclinical-cardiovascular-disease-and-systemic-sclerosis-a-comparison-between-risk-charts-quantification-of-coronary-calcium-and-carotid-ultrasonography
#8
REVIEW
I Sanz Pérez, F Martínez Valle, A Guillén Del Castillo, A Roque Pérez, H Cuéllar Calàbria, M N Pizzi, A Fernández Codina, E Callejas Moragas, O Orozco Gálvez, V Fonollosa Pla, C P Simeón Aznar
BACKGROUND AND OBJECTIVES: Recently published population-based cohort studies have shown a high prevalence of cardiovascular disease in Systemic Sclerosis (SSc) patients. The aim of this study is to compare three different methods to measure cardiovascular risk in patients with scleroderma. METHODS: Forty-three SSc patients were included. A prospective study was performed for evaluation of cardiovascular risk and subclinical atheromatosis using 3 non-invasive methods: cardiovascular risk tables, carotid Doppler ultrasonography and quantification of coronary calcium by computerized tomography (CT)...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005857/nature-versus-nurture-in-the-spectrum-of-rheumatic-diseases-classification-of-spondyloarthritis-as-autoimmune-or-autoinflammatory
#9
REVIEW
Elena Generali, Tanima Bose, Carlo Selmi, J Willem Voncken, Jan G M C Damoiseaux
Spondyloarthritides (SpA) include inflammatory joint diseases with various clinical phenotypes that may also include the axial skeleton and/or entheses. SpA include psoriatic arthritis, reactive arthritis, enteropathic arthritis and ankylosing spondylitis; the latter is frequently associated with extra-articular manifestations, such as uveitis, psoriasis, and inflammatory bowel disease. SpA are associated with the HLA-B27 allele and recognize T cells as key pathogenetic players. In contrast to other rheumatic diseases, SpA affect women and men equally and are not associated with detectable serum autoantibodies...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005856/inflammation-and-dementia-using-rheumatoid-arthritis-as-a-model-to-develop-treatments
#10
REVIEW
Alice Mason, Clive Holmes, Christopher J Edwards
Dementia is a major international public health problem which looks set to grow as the ageing population increases. Despite large amounts of investment there has been relatively little progress in developing new therapies to combat this. There is a growing body of evidence that both local and systemic inflammation are important in dementia; with cerebral inflammation occurring secondarily to beta-amyloid plaques, raised levels of serum inflammatory molecules and cytokines being present in Alzheimer's disease patients and systemic inflammation being associated with cerebral microvasculature disease in vascular dementia...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005855/letter-to-the-editor-autoimmune-pathogenic-mechanisms-in-huntington-s-disease
#11
LETTER
Antonio Greco, Massimo Ralli, Armando De Virgilio, Maurizio Inghilleri, Massimo Fusconi, Marco de Vincentiis
No abstract text is available yet for this article.
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005854/drug-induced-lupus-traditional-and-new-concepts
#12
REVIEW
Augusto Vaglio, Peter C Grayson, Paride Fenaroli, Davide Gianfreda, Valeria Boccaletti, Gian Marco Ghiggeri, Gabriella Moroni
Drug-induced lupus (DIL) includes a spectrum of drug-induced reactions often characterised by a clinical phenotype similar to that of idiopathic systemic lupus eruthematosus (SLE) but usually lacking major SLE complications. Different drugs may be associated with distinct clinical and serological profiles, and early recognition is crucial. Drugs traditionally associated with DIL include procainamide, hydralazine, quinidine and others, but strong associations with newer agents, such as TNF α (TNFα) inhibitors, are increasingly recognised...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30005853/efficacy-and-patient-satisfaction-in-the-use-of-subcutaneous-immunoglobulin-immunotherapy-for-the-treatment-of-auto-immune-neuromuscular-diseases
#13
REVIEW
Taylor Pindi Sala, Jean-Charles Crave, Martin Duracinsky, Lepira Bompeka, Abir Tadmouri, Olivier Chassany, Patrick Cherin
We reviewed the efficacy of SCIg administration in terms of muscle strength maintenance and patient satisfaction comparing with IVIg in the treatment of auto-immune neuromuscular diseases. A systematic review was conducted, and identified studies from databases (PUBMED, EMBASE, EBSCO, Web of Science and Google Scholar) which were analyzed. The methodological quality of the selected publications was evaluated using the Newcastle-Ottawa Scale. Data were extracted from a total of 11 studies Fixed and random-effect model meta-analyses were performed...
July 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29890348/autosomic-dominant-familial-beh%C3%A3-et-disease-and-haploinsufficiency-a20-a-review-of-the-literature
#14
REVIEW
Berteau Florian, Rouviere Bénédicte, Delluc Aurélien, Nau Alice, Le Berre Rozenn, Sarrabay Guillaume, Touitou Isabelle, Claire de Moreuil
INTRODUCTION: Behçet disease (BD) is a systemic vasculitis involving vessels from any size with various clinical features. Most BD cases are multifactorial and associated with the HLA B51 antigen. In rare and severe early onset cases, dominant Mendelian transmission has been linked to mutations in the TNFAIP3 gene encoding A20. Herein, we propose a systematic review of the literature about the haploinsufficiency A20 (HA20) published cases. SYSTEMATIC REVIEW: Our review of the 45 cases of HA20 from literature highlights the similarities and the differences between this genetic auto-inflammatory disease and classical BD...
June 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29890347/endoplasmic-reticulum-stress-in-autoimmune-diseases-can-altered-protein-quality-control-and-or-unfolded-protein-response-contribute-to-autoimmunity-a-critical-review-on-sj%C3%A3-gren-s-syndrome
#15
REVIEW
María-José Barrera, Sergio Aguilera, Isabel Castro, Sergio González, Patricia Carvajal, Claudio Molina, Marcela A Hermoso, María-Julieta González
For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the importance of target tissues in their pathogenesis and the breach of immune tolerance. The immune system as well as target tissue cells (plasmatic, β-pancreatic, fibroblast-like synoviocytes, thyroid follicular and epithelial cells of the lachrymal glands, salivary glands, intestine, bronchioles and renal tubules) share the characteristic of secretory cells with an extended endoplasmic reticulum (ER)...
June 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29885968/symptomatic-polyautoimmunity-at-diagnosis-of-1463-childhood-onset-lupus-a-brazilian-multicenter-study
#16
REVIEW
Debora N Setoue, Ana C Pitta, Fernanda J Fiorot, Mariana M Nastri, Glaucia V Novak, Beatriz C Molinari, Juliana C Oliveira, Natali W Gormezano, Ana P Sakamoto, Maria T Terreri, Rosa M Pereira, Claudia Saad-Magalhães, Adriana M Sallum, Katia Kozu, Melissa M Fraga, Daniela P Piotto, Gleice Clemente, Roberto Marini, Hugo R Gomes, Carlos N Rabelo-Junior, Marta M Felix, Maria C Ribeiro, Rozana G Almeida, Ana P Assad, Silvana B Sacchetti, Leandra C Barros, Eloisa Bonfá, Clovis A Silva
OBJECTIVE: To evaluate symptomatic polyautoimmunity (PA) at childhood-onset systemic lupus erythematosus(cSLE) diagnosis, and its association with demographic data, disease activity, clinical manifestations and laboratorial abnormalities in a large Brazilian cSLE population. METHODS: A multicenter retrospective study was performed in 1463 cSLE(ACR criteria) patients from 27 Pediatric Rheumatology services. Symptomatic PA was defined according to the presence of more than one concomitant autoimmune disease(AD) and symptomatic multiple autoimmune syndrome(MAS) was defined as three or more AD...
June 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29885545/polyautoimmunity-the-missing-ingredient
#17
LETTER
Gabriel Samasca, Ramesh Ajay, Daniel Sur, Cornel Aldea, Lucia Sur, Emanuela Floca, Genel Sur, Iulia Lupan, Matthias Torsten, Lerner Aaron
No abstract text is available yet for this article.
June 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29885546/the-use-of-interleukin-1-receptor-antagonist-anakinra-in-kawasaki-disease-a-retrospective-cases-series
#18
REVIEW
Isabelle Kone-Paut, Rolando Cimaz, Jethro Herberg, Oliver Bates, Aurelia Carbasse, Jean Pierre Saulnier, Maria Cristina Maggio, Jordi Anton, Maryam Piram
OBJECTIVES: To identify the clinical characteristics, reasons for use and response to treatment with anakinra in a series of patients with Kawasaki Disease (KD). STUDY DESIGN: A retrospective chart review of patients treated with anakinra for KD diagnosed according to the AHA criteria. We compared clinical, biological and echocardiographic characteristics of KD before and after anakinra use. We analysed reasons for use of anakinra, and compared treatment regimens used in 7 European KD referral centres...
June 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29885544/the-2018-pipeline-of-targeted-therapies-under-clinical-development-for-systemic-lupus-erythematosus-a-systematic-review-of-trials
#19
REVIEW
Renaud Felten, Elida Dervovic, François Chasset, Jacques-Eric Gottenberg, Jean Sibilia, Florence Scher, Laurent Arnaud
Currently, Systemic Lupus Erythematosus (SLE) therapies range from antimalarials to glucocorticoids, in addition to immunosupressive agents or biologics such as rituximab or belimumab, when needed. Several unmet needs remain in the treatment SLE and more targeted drugs with improved safety profiles are expected. Based on recent advances in the understanding of the complex pathogenesis of SLE, several targeted treatments are currently assessed in clinical trials. In this study, we performed a systematic review of all targeted therapies under clinical development in SLE in 17 online registries of clinical trials...
June 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29885543/polyautoimmunity-risk-factors-for-a-unique-clinical-entity
#20
LETTER
Oded Shamriz
No abstract text is available yet for this article.
June 6, 2018: Autoimmunity Reviews
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