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Autoimmunity Reviews

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https://www.readbyqxmd.com/read/29730525/inflammation-and-atherosclerosis-cardiovascular-evaluation-in-patients-with-autoimmune-diseases
#1
REVIEW
Ricardo O Escárcega, Michael J Lipinski, Mario García-Carrasco, Claudia Mendoza-Pinto, Jose Luis Galvez-Romero, Ricard Cervera
Evidence now indicates that inflammation contributes considerably to the initiation and progression of atherosclerosis and active inflammatory processes may trigger plaque rupture and enhance the risk of coronary thrombosis leading to a clinical ischemic event. Interest in characterizing inflammatory markers that predict clinical events have dominated clinical investigation. Such markers include C-reactive protein, Fibrinogen and a number of interleukins. Human macrophages avidly phagocytize cholesterol crystals...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29730524/mortality-in-systemic-necrotizing-vasculitides-a-retrospective-analysis-of-the-french-vasculitis-study-group-registry
#2
REVIEW
Sabine Jardel, Xavier Puéchal, Alain Le Quellec, Christian Pagnoux, Mohamed Hamidou, François Maurier, Olivier Aumaitre, Achille Aouba, Thomas Quemeneur, Jean-François Subra, Vincent Cottin, Jean Sibilia, Pascal Godmer, Patrice Cacoub, Anne Laure Fauchais, Eric Hachulla, Delphine Maucort-Boulch, Loïc Guillevin, Jean-Christophe Lega
OBJECTIVE: The aim of the study was to describe the evolution of mortality and cause-specific mortality over time in patients with systemic necrotizing vasculitides (SNV), including polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). METHODS: Patients with SNV from the French Vasculitis Study Group registry were divided into 5 groups according to the date of diagnosis: <1980, 1980-1989, 1990-1999, 2000-2010, and ≥ 2010...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729453/the-slam-family-receptors-potential-therapeutic-targets-for-inflammatory-and-autoimmune-diseases
#3
REVIEW
Matthew A Dragovich, Adam Mor
The signaling lymphocytic activation molecule (SLAM) family is comprised of nine distinct receptors (SLAMF1 through SLAMF9) that are expressed on hematopoietic cells. All of these receptors, with the exception of SLAMF4, are homotypic by nature as downstream signaling occurs when hematopoietic cells that express the same SLAM receptor interact. The SLAM family receptor function is largely controlled via SLAM associated protein (SAP) family adaptors. The SAP family adaptors consist of SAP, Ewing sarcoma associated transcript (EAT)-2, and EAT-2-related transducer (ERT)...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729452/cytokine-markers-of-b-lymphocytes-in-minor-salivary-gland-infiltrates-in-sj%C3%A3-gren-s-syndrome
#4
REVIEW
Erika P Navarro-Mendoza, David Aguirre-Valencia, Iván Posso-Osorio, Shirley Vanessa Correa-Forero, Daniel-Felipe Torres-Cutiva, Diana Loaiza, Gabriel J Tobón
Sjögren's syndrome (SS) is a chronic autoimmune disorder characterised by the clinical presence of sicca syndrome. SS compromises the dysfunction of exocrine glands due to the presence of focal, mononuclear cell infiltrates that surround the ducts and replace the secretory units. Abnormal expression of different cytokines and chemokines such as B-cell activating factor, CXC Motif Chemokine Ligand 13, interleukin 6 (IL-6), IL-22, and FMS-like tyrosine kinase 3 ligand as well as that of their corresponding receptors has been implicated in the inflammatory process...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729445/emerging-role-of-il-35-in-inflammatory-autoimmune-diseases
#5
REVIEW
Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang, Wang-Dong Xu
Interleukin 35 (IL-35) is the recently identified member of the IL-12 family of cytokines and provides the possibility to be a target for new therapies for autoimmune, inflammatory diseases. It is composed of an α chain (p35) and a β chain (EBI3). IL-35 mediates signaling by binding to its receptors, activates subsequent signaling pathways, and therefore, regulates the differentiation, function of T, B cells, macrophages, dendritic cells. Recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 1 diabetes, psoriasis, multiple sclerosis, autoimmune hepatitis, experimental autoimmune uveitis...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729451/disease-course-and-long-term-outcome-of-juvenile-localized-scleroderma-experience-from-a-single-pediatric-rheumatology-centre-and-literature-review
#6
REVIEW
Giorgia Martini, Gloria Fadanelli, Anna Agazzi, Fabio Vittadello, Alessandra Meneghel, Francesco Zulian
Juvenile Localized Scleroderma (JLS) is a rare disorder that may cause severe aesthetic sequelae and functional disability. To date, data on natural history and long-term outcome are discordant and difficult to compare due to the heterogeneity of clinical subtypes, treatments and methods to evaluate activity and outcome in previous studies. A retrospective and cross-sectional study including 133 patients followed between January 1991 and December 2016 was conducted at our Pediatric Rheumatology Centre. Disease course was drawn by retrospective analysis of patients' clinical features, treatment, disease course and outcome at the last evaluation...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729450/new-use-for-an-old-treatment-hydroxychloroquine-as-a-potential-treatment-for-systemic-vasculitis
#7
REVIEW
Alina Casian, Shirish Sangle, David P D'Cruz
Antimalarials have been an effective and safe treatment for autoimmune rheumatic diseases such as systemic lupus erythematosus for more than a hundred years. There are surprisingly few reports of hydroxychloroquine use in the systemic vasculitides. Hydroxychloroquine has antithrombotic, cardiovascular, antimicrobial and antineoplastic effects, making it a potentially valuable treatment for patients with systemic vasculitis who are at risk of infections, malignancy and thrombotic events. We report the successful use of hydroxychloroquine in patients with ANCA vasculitis, Henoch Schonlein purpura/IgA vasculitis, Takayasu's arteritis and polyarteritis nodosa...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729449/nlrp3-a-promising-therapeutic-target-for-autoimmune-diseases
#8
REVIEW
Hui-Hui Shen, Yue-Xin Yang, Xiang Meng, Xiao-Yun Luo, Xiao-Mei Li, Zong-Wen Shuai, Dong-Qing Ye, Hai-Feng Pan
NLRP3, a member of nucleotide-binding domain-(NOD)like receptor family, can be found in large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis-associated speck-like protein (ASC) and pro-caspase-1 would assemble into a multimeric protein, called the NLRP3 inflammasome. Then the inflammasome promotes inflammation (through specific cleavage and production of bioactive IL-1β and IL-18) and pyroptotic cell death. Previous studies have indicated the importance of NLRP3 in regulating innate immunity...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729448/quality-of-life-and-neuropsychiatric-disorders-in-patients-with-graves-orbitopathy-current-concepts
#9
REVIEW
Alice Bruscolini, Marta Sacchetti, Maurizio La Cava, Marcella Nebbioso, Angela Iannitelli, Adele Quartini, Alessandro Lambiase, Massimo Ralli, Armando de Virgilio, Antonio Greco
Graves' disease (GD) is an autoimmune chronic thyroiditis frequently associated with development of Graves' orbitopathy (GO) characterized by proptosis, strabismus, impairment of visual function, ocular surface inflammation and dry eye. As consequence, patients with GO experience impairment of quality of life and social function and could develop a neurobehavioral syndrome, ranging from anxious to depressive or psychotic disorders. To date, the pathogenic mechanism underlying neuropsychiatric disorders in patients with GD has not been clearly understood...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729447/animal-studies-are-mandatory-to-investigate-the-poorly-understood-fate-and-effects-of-aluminum-adjuvants-administered-to-billions-of-humans-and-animals-worldwide
#10
LETTER
Romain K Gherardi, Guillemette Crépeaux, François-Jerome Authier, Lluis Lujan
No abstract text is available yet for this article.
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729446/hearing-loss-in-autoimmune-disorders-prevalence-and-therapeutic-options
#11
REVIEW
Patrizia Mancini, Francesca Atturo, Alessia Di Mario, Portanova Ginevra, Massimo Ralli, Armando De Virgilio, Marco de Vincentiis, Antonio Greco
The objective of this study was to review our current knowledge relative to the correlation between sensorineural hearing loss (SNHL) and autoimmune diseases, focusing on the prevalence of hearing loss in different pathologies and possible therapeutic approaches. A review of the literature on hearing loss in different forms of autoimmune disease has been carried out, with emphasis on incidence and prevalence of SNHL. Therapeutic protocols have been assessed including both conservative medical and rehabilitative methods...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729444/non-glucocorticoid-drugs-for-the-treatment-of-takayasu-s-arteritis-a-systematic-review-and-meta-analysis
#12
REVIEW
Lillian Barra, Grace Yang, Christian Pagnoux
BACKGROUND: Takayasu's Arteritis (TAK) affects mostly young women and causes significant morbidity. Most patients are refractory to glucocorticoids (GC) or relapse when GC doses are reduced. The objective of this study is to summarize the literature pertaining to the effectiveness of non-GC drugs for the treatment of TAK. METHODS: MEDLINE and Embase were searched for English-language studies of TAK patients with a sample size >5. Studies were included if the effectiveness of non-GC drugs for the treatment of TAK was reported...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29729443/positron-emission-tomography-pet-and-single-photon-emission-computed-tomography-spect-imaging-of-macrophages-in-large-vessel-vasculitis-current-status-and-future-prospects
#13
REVIEW
William Febry Jiemy, Peter Heeringa, Jan A A M Kamps, Conny J van der Laken, Riemer H J A Slart, Elisabeth Brouwer
Macrophages are key players in the pathogenesis of large-vessel vasculitis (LVV) and may serve as a target for diagnostic imaging of LVV. The radiotracer, 18 F-FDG has proven to be useful in the diagnosis of giant cell arteritis (GCA), a form of LVV. Although uptake of 18 F-FDG is high in activated macrophages, it is not a specific radiotracer as its uptake is high in any proliferating cell and other activated immune cells resulting in high non-specific background radioactivity especially in aging and atherosclerotic vessels which dramatically lowers the diagnostic accuracy...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29641988/should-rheumatoid-factor-rf-and-antinuclear-antibodies-ana-become-routinary-screening-test-for-morbidities-in-the-general-population-from-the-concept-of-benign-autoimmunity-to-the-concept-of-autoimmunity-as-a-red-flag-in-preventive-medicine
#14
LETTER
https://www.readbyqxmd.com/read/29635081/myalgic-encephalomyelitis-chronic-fatigue-syndrome-evidence-for-an-autoimmune-disease
#15
REVIEW
Franziska Sotzny, Julià Blanco, Enrica Capelli, Jesús Castro-Marrero, Sophie Steiner, Modra Murovska, Carmen Scheibenbogen
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent and severe chronic disease drastically impairing life quality. The underlying pathomechanism is incompletely understood yet but there is convincing evidence that in at least a subset of patients ME/CFS has an autoimmune etiology. In this review, we will discuss current autoimmune aspects for ME/CFS. Immune dysregulation in ME/CFS has been frequently described including changes in cytokine profiles and immunoglobulin levels, T- and B-cell phenotype and a decrease of natural killer cell cytotoxicity...
April 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29635080/efficacy-and-safety-of-rituximab-in-systemic-sclerosis-french-retrospective-study-and-literature-review
#16
REVIEW
Mathilde Thiebaut, David Launay, Sébastien Rivière, Thibault Mahévas, Syrine Bellakhal, Eric Hachulla, Olivier Fain, Arsène Mekinian
OBJECTIVE: To describe safety and efficacy of rituximab in patients with systemic sclerosis. METHODS: We included 13 patients with systemic sclerosis treated with rituximab and pooled with 40 additional patients from the literature. SSc rituximab untreated patients were matched to rituximab treated ones. RESULTS: Thirteen patients who received rituximab and 26 rituximab-untreated patients were included. In comparison to 26 patients who did not received rituximab, FVC changes were not significantly different, whereas DLCO improved in 13 patients who received rituximab (0 [-4; 4] vs loss of -7 [-19; 0]; p=0...
April 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29635079/antinuclear-antibodies-is-the-indirect-immunofluorescence-still-the-gold-standard-or-should-be-replaced-by-solid-phase-assays
#17
REVIEW
Dolores Pérez, Boris Gilburd, Danielle Azoulay, Ora Shovman, Nicola Bizzaro, Yehuda Shoenfeld
No abstract text is available yet for this article.
April 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29635077/systemic-lupus-erythematosus-and-systemic-sclerosis-all-roads-lead-to-platelets
#18
REVIEW
Marc Scherlinger, Vivien Guillotin, Marie-Elise Truchetet, Cécile Contin-Bordes, Vanja Sisirak, Pierre Duffau, Estibaliz Lazaro, Christophe Richez, Patrick Blanco
Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are two phenotypically distincts inflammatory systemic diseases. However, SLE and SSc share pathogenic features such as interferon signature, loss of tolerance against self-nuclear antigens and increased tissue damage such as fibrosis. Recently, platelets have emerged as a major actor in immunity including auto-immune diseases. Both SLE and SSc are characterized by strong platelet system activation, which is likely to be both the witness and culprit in their pathogenesis...
April 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29635076/the-role-of-ophthalmic-imaging-in-central-nervous-system-degeneration-in-systemic-lupus-erythematosus
#19
REVIEW
Arnaldo Dias-Santos, Rita Pinto Proença, Joana Tavares Ferreira, Sofia Pinheiro, João Paulo Cunha, Rui Proença, Maria Francisca Moraes-Fontes
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that can involve any organ system. Central nervous system involvement can be a severe life threatening complication, ultimately resulting in severe neurodegenerative changes. Magnetic resonance imaging suggests that neurodegeneration, which may have deleterious effects on brain function, may occur early in SLE and experimental models suggest that neuroprotection may be feasible and beneficial. The retina is an extension of the brain...
April 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29635075/from-hsv-infection-to-erythema-multiforme-through-autoimmune-crossreactivity
#20
REVIEW
Alberta Lucchese
Scientific and clinical data indicate that human herpes simplex virus 1 (HSV1) and, at a lesser extent, human herpes simplex virus 2 (HSV2) are factor(s) implicated in the development of erythema multiforme (EM). With a focus on oral EM, the present structured review of proteomic and epitope databases searched for the molecular basis that might link HSV1 and HSV2 infections to EM. It was found that a high number of peptides are shared between the two HSVs and human proteins related to the oral mucosa. Moreover, a great number of the shared peptides are also present in epitopes that have been experimentally validated as immunopositive in the human host...
April 7, 2018: Autoimmunity Reviews
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