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Autoimmunity Reviews

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https://www.readbyqxmd.com/read/30414949/characterization-of-the-thymus-in-lrp4-myasthenia-gravis-four-cases
#1
REVIEW
Inga Koneczny, Dorit Rennspiess, Florit Marcuse, Myurgia Abdul Hamid, Marina Damas, Jos Maessen, Paul Van Schil, Abhishek Saxena, Paraskevi Zisimopoulou, Konstantinos Lazaridis, Mark Woodhall, Katerina Karagiorgou, John Tzartos, Socrates Tzartos, Marc H De Baets, Peter C Molenaar, Alexander Marx, Axel Zur Hausen, Mario Losen, Pilar Martinez-Martinez
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction. Most patients have pathogenic autoantibodies against the acetylcholine receptor (AChR). In the last years a novel subpopulation of MG patients has been described that harbors antibodies against low-density lipoprotein receptor-related protein 4 (Lrp4), another postsynaptic neuromuscular antigen. In early-onset AChR MG (EOMG), the thymus plays an important role in immunopathogenesis, and early thymectomy is beneficial. It is still unknown if the thymus plays any role in Lrp4-MG...
November 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408589/x-chromosome-and-female-bias-in-systemic-lupus-erythematosus-focus-on-population-based-evidence
#2
LETTER
Dongsheng Di, Hui Yuan, Linlin Zhang, Xiaoxiao Wu, Haifeng Pan, Dongqing Ye, Ruixue Leng
No abstract text is available yet for this article.
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408588/diagnostic-performance-of-temporal-artery-ultrasound-for-the-diagnosis-of-giant-cell-arteritis-a-systematic-review-and-meta-analysis-of-the-literature
#3
REVIEW
Marina Rinagel, Emmanuel Chatelus, Sandrine Jousse-Joulin, Jean Sibilia, Jacques-Eric Gottenberg, François Chasset, Laurent Arnaud
Despite major recent advances in the therapeutic management of Giant cell arteritis (GCA), the diagnosis accuracy of temporal artery ultrasound remains controversial in this disease. We performed a systematic review to determine the sensitivity, specificity, and summary positive (LR+) and negative (LR-) likelihood ratios of temporal artery ultrasound for the diagnosis of GCA. For this, we searched EMBASE, MEDLINE and the Cochrane Database of Systematic Reviews without language restriction. Original articles reporting on diagnostic accuracy of temporal artery ultrasound compared to temporal artery biopsy, for the diagnosis of GCA, were selected...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408587/liver-associated-immune-abnormalities
#4
REVIEW
Eyal Grunebaum, Yaron Avitzur
In recent years, the cross talk between the liver and the immune system is being uncovered, in part by studying liver involvement in primary immune deficiencies (PID) and in part by investigating the alterations of the immune system following orthotic liver transplantation (OLT). Here we review some of the reciprocal interactions between the liver and the immune system. Patients with PID, particularly those involving inherited defects in T and B cells or innate immunity are prone to infections and inflammatory responses that often involve the liver...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408586/validation-and-meta-analysis-of-kappa-index-biomarker-in-multiple-sclerosis-diagnosis
#5
REVIEW
Paloma Menéndez-Valladares, Maria Isabel García-Sánchez, Myriam Adorna Martínez, Jose Luis García De Veas Silva, Carmen Bermudo Guitarte, Guillermo Izquierdo Ayuso
The importance of studying the cerebrospinal fluid (CSF) in Multiple Sclerosis (MS) is included in the last McDonald criteria (2018). The study of oligoclonal IgG bands (OCGB) assay is strongly recommended in some situations in which MS diagnosis is uncertain. New biomarkers are developed during the last years. Kappa free light chains (FLC) can predict conversion to MS in patients with Clinically Isolated Syndrome (CIS). The aim of this work is to validate the clinical usefulness of the kappa index, and to establish the actual state of knowledge for kappa index as a biomarker of conversion in CIS patients by a meta-analysis...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408585/arthritis-in-primary-sj%C3%A3-gren-s-syndrome-characteristics-outcome-and-treatment-from-french-multicenter-retrospective-study
#6
REVIEW
Adrien Mirouse, Raphaèle Seror, Eric Vicaut, Xavier Mariette, Maxime Dougados, Anne-Laure Fauchais, Alban Deroux, Azeddine Dellal, Nathalie Costedoat-Chalumeau, Guillaume Denis, Jérémie Sellam, Jean-Benoît Arlet, Christian Lavigne, Geoffrey Urbanski, Dominique Fischer-Dumont, Abdou Diallo, Olivier Fain, Arsène Mékinian
OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen. METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls)...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408584/the-characteristics-and-pivotal-roles-of-triggering-receptor-expressed-on-myeloid-cells-1-in-autoimmune-diseases
#7
REVIEW
Sheng Gao, Yongdong Yi, Guojun Xia, Chengyang Yu, Chenmin Ye, Fuyang Tu, Leibin Shen, Wenqian Wang, Chunyan Hua
Triggering receptor expressed on myeloid cells-1 (TREM-1) engagement can directly trigger inflammation or amplify an inflammatory response by synergizing with TLRs or NLRs. Autoimmune diseases are a family of chronic systemic inflammatory disorders. The pivotal role of TREM-1 in inflammation makes it important to explore its immunological effects in autoimmune diseases. In this review, we summarize the structural and functional characteristics of TREM-1. Particularly, we discuss recent findings on TREM-1 pathway regulation in various autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), type 1 diabetes (T1D), and psoriasis...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408583/autoimmune-diseases-in-myelodysplastic-syndrome-favors-patients-survival-a-case-control-study-and-literature-review
#8
REVIEW
Julie Seguier, Véronique Gelsi-Boyer, Mikael Ebbo, Zeinab Hamidou, Aude Charbonnier, Emmanuelle Bernit, Jean-Marc Durand, Jean-Robert Harlé, Norbert Vey, Nicolas Schleinitz
BACKGROUND: We conducted a monocentric retrospective study of patients with myelodysplastic syndromes (MDS) and autoimmune or inflammatory disorders (AIMs) and a literature review. We analyzed the association with subgroups of the WHO 2016 MDS classification and patient's survival in a case control study. Risk factors associated with survival were analyzed by uni- and multivariate analysis. RESULTS: From all MDS patients 11% presented with AIMs. These were heterogeneous and the most frequent where polyarthritis (25%) and autoimmune cytopenias (17%)...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408582/guidelines-for-biomarkers-in-autoimmune-rheumatic-diseases-evidence-based-analysis
#9
REVIEW
Roberto Giacomelli, Antonella Afeltra, Alessia Alunno, Elena Bartoloni-Bocci, Onorina Berardicurti, Michele Bombardieri, Alessandra Bortoluzzi, Roberto Caporali, Francesco Caso, Ricard Cervera, Maria Sole Chimenti, Paola Cipriani, Emmanuel Coloma, Fabrizio Conti, Salvatore D'Angelo, Salvatore De Vita, Salvatore Di Bartolomeo, Oliver Distler, Andrea Doria, Eugen Feist, Benjamin A Fisher, Maria Gerosa, Michele Gilio, Giuliana Guggino, Vasiliki Liakouli, Domenico Paolo Emanuele Margiotta, Pierluigi Meroni, Gianluca Moroncini, Federico Perosa, Marcella Prete, Roberta Priori, Chiara Rebuffi, Piero Ruscitti, Raffaele Scarpa, Yehuda Shoenfeld, Monica Todoerti, Francesco Ursini, Guido Valesini, Serena Vettori, Claudio Vitali, Athanasios G Tzioufas
Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it has been shown that clinical remission is reached in less than 50% of patients and a personalised and tailored therapeutic approach is still lacking resulting in a significant gap between guidelines and real-world practice. In this context, the need for biomarkers facilitating early diagnosis and profiling those individuals at the highest risk for a poor outcome has become of crucial interest...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408581/immunogenicity-safety-and-tolerability-of-anti-pneumococcal-vaccination-in-systemic-lupus-erythematosus-patients-an-evidence-informed-and-prisma-compliant-systematic-review-and-meta-analysis
#10
REVIEW
Nicola Luigi Bragazzi, Dennis McGonagle, Samaa Watad, Mohammad Adawi, Naim Mahroum, Giovanni Damiani, Rosalynn Conic, Charlie Bridgewood, Hussein Mahagna, Luca Giacomelli, Roberto Eggenhöffner, Mahmud Mahamid, Paolo Daniele Maria Pigatto, Howard Amital, Abdulla Watad
The immunological perturbations associated with systemic lupus erythematosus (SLE) puts many patients at higher risk of infections including pneumococcal pneumonia. However, the uptake and utility of anti-pneumococcal vaccines in SLE patient is both controversial and not completely agreed on. Indeed, several epidemiological studies of anti-pneumococcal vaccine safety and efficacy in SLE have reported short term immunogenicity with elevated anti-pneumococcal antibody titres but inconsistent long term findings with some studies finding poor responses, mainly for long-term immune protection...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408580/adrenal-insufficiency-in-systematic-lupus-erythematosus-sle-and-antiphospholipid-syndrome-aps-a-systematic-review
#11
REVIEW
Keum Hwa Lee, HyunJeong Lee, Cheol-Hun Lee, Jin Yeong Kim, Jong Min Kim, Se Seung Kim, Seungmin Jeong, In Sung Hwang, Namsoo Kim, Na Eun Kim, Soogeun Shin, Dongkwan Shin, Joo Sang Song, Dong Hyun Shin, Jung Dong Kim, Jeehoon Kim, Yong Seok Lee, Hansung Kang, Dong Ha Kim, So Hyun Moon, Won Suk Rho, Joo Yeon Lee, Andreas Kronbichler, Jae Il Shin
BACKGROUND: Adrenal insufficiency (AI) is associated with high morbidity and mortality. The aim of this systematic review was to enhance diagnostic approaches and summarize therapeutic strategies in the management of AI in patients with an underlying prior disease history. METHODS: A literature search of PubMed and EMBASE databases was performed and 91 publications containing 105 cases were included for the final analysis. RESULTS: The following frequency of clinical signs and symptoms was noted: abdominal pain (39...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408579/target-therapy-in-sle
#12
REVIEW
Matthias Schneider
The intention of this paper is to review actual developments in target therapy in SLE. Target therapy includes both the objective of intervention and the aim of treatment. The objective should be linked to the pathophysiologic process of SLE; the aim has to be in any case an improved outcome. The current therapeutic in SLE is guided mostly by secondary prevention. In SLE, besides a BASIC concept with antimalarials, bone and sun protection, vaccination and cardiovascular risk minimising, treatment waits for new manifestations to be started to prevent secondarily damage...
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30408578/dampness-and-mold-hypersensitivity-syndrome-and-vaccination-as-risk-factors-for-chronic-fatigue-syndrome
#13
LETTER
Tamara Tuuminen, Tiina Jääskeläinen, Kirsi Vaali, Olli Polo
No abstract text is available yet for this article.
November 5, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30404042/systemic-sclerosis-and-exposure-to-heavy-metals
#14
REVIEW
Isabelle Marie
As a mirror image of the Roman god Janus Bifrons, the environment has a hidden face. To highlight this hidden face of the environment in the field of systemic sclerosis (SSc) will allow to identify responsible agents emerging in the future. To date, there is, in fact, a growing scientific evidence that environmental factors have a crucial impact on both alterations and modulation of epigenetic determinants, resulting in SSc onset and progression. It has been well established that there is a marked correlation between SSc onset and occupational exposure to crystalline silica and organic solvents...
November 4, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30339886/the-profiling-of-axial-spondyloarthritis-patient-candidate-to-a-biologic-therapy-consensus-from-a-delphi-panel-of-italian-experts
#15
REVIEW
Ennio Giulio Favalli, Andrea Becciolini, Roberto Caporali, Monica Todoerti, Florenzo Iannone, Liliana Dinoia, Marco Sebastiani, Amelia Spinella, Elisa Gremese, Francesco Cianci, Fabiola Atzeni, Francesca Bandinelli, Gianfranco Ferraccioli, Giovanni Lapadula
OBJECTIVE: The project aimed to collect expert consensus statements for the profiling of patients with axial spondyloarthritis (axSpA) candidate to biologic agents (bDMARDs) treatment, in order to better define the drivers for the best treatment choice. METHODS: The 6 more interesting topics about axSpA patient profiling were identified by the project steering committee and a panel of axSpA Italian experts. A systematic literature review (SLR) was performed for each of the selected topics according to the PICO format...
October 16, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30321671/with-focus-on-autoimmune-liver-diseases
#16
REVIEW
Audrey Beringer, Pierre Miossec
The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune / inflammatory diseases. More recently, they have been associated with liver diseases. This review first describes the general knowledge on IL-17 and IL-17 producing cells. The second part describes the in vitro and in vivo effects of IL-17 on liver cells and the contribution of IL-17 producing cells to liver diseases. IL-17 induces immune cell infiltration and liver damage driving to hepatic inflammation and fibrosis and contributes to autoimmune liver diseases...
October 12, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30316997/recent-advances-in-mouse-models-for-systemic-sclerosis
#17
REVIEW
Xiaoyang Yue, Xinhua Yu, Frank Petersen, Gabriela Riemekasten
SSc is a complex rheumatoid disease characterized by autoimmunity, fibrosis and vasculopathy. Mouse models provide powerful research tools for exploring the pathogenesis of the human diseases. Each mouse model can represent a specific way leading to the development of disease. Moreover, mouse models can be used to investigate the role of candidate molecule in the pathogenesis of disease. So far, more than twenty mouse models for SSc have been established and provide new insights in the understanding of the pathogenesis of SSc...
October 12, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30316995/autoinflammatory-autoimmunity-syndrome-induced-by-adjuvants-asia-shoenfeld-s-syndrome-a-new-flame
#18
REVIEW
Jan Willem Cohen Tervaert
In the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias, myalgias, pyrexia, dry eyes and dry mouth. During the last few years, it has been postulated that these symptoms in patients with foreign body implants are due to a chronic inflammatory process and an adjuvant effect of the implanted biomaterial. Ultimately, these inflammatory reactions result in (an increase of) allergies, autoimmune diseases, immune deficiency and/or lymphomas...
October 12, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30316991/low-dose-tocilizumab-for-relapsing-giant-cell-arteritis-in-the-elderly-fragile-patient-beyond-the-giacta-trial
#19
LETTER
Giovanni Maria Rossi, Alessandro Mannoni, Gerardo Di Scala, Elena Silvestri, Rafaela Diana Cojan, Lorenzo Vannozzi, Alessandra Bettiol, Augusto Vaglio, Giacomo Emmi
No abstract text is available yet for this article.
October 12, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30316988/dimethyl-fumarate-treatment-in-multiple-sclerosis-recent-advances-in-clinical-and-immunological-studies
#20
REVIEW
Gwendoline Montes Diaz, Raymond Hupperts, Judith Fraussen, Veerle Somers
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which demyelination and neurodegeneration occurs. The immune system of MS patients is characterized by a dysregulation in the balance between pro- and anti-inflammatory immune cells, whereby both the innate and adaptive immune system are involved. Dimethyl fumarate (DMF) was licensed in 2013 as an oral first-line therapy for relapsing-remitting (RR)MS patients. It has a strong efficacy with neuroprotective and immunomodulatory effects and a favourable benefit-risk profile...
October 12, 2018: Autoimmunity Reviews
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