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Autoimmunity Reviews

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https://www.readbyqxmd.com/read/28285170/novel-risk-factors-related-to-cancer-in-scleroderma
#1
REVIEW
David Bernal-Bello, Jaime García de Tena, Alfredo Guillén-Del Castillo, Albert Selva-O'Callaghan, Eduardo L Callejas-Moraga, Ana María Marín-Sánchez, Vicent Fonollosa-Pla, Carmen Pilar Simeón-Aznar
OBJECTIVE: Emerging data have shown an increased risk of malignancy among patients diagnosed with systemic sclerosis (SSc) so identification of risk factors linking both disorders might have prognostic implications. The aim of this study was to assess the clinical and treatment-related risk factors for cancer in a single-center cohort of patients with SSc. METHODS: Demographic, clinical, capillaroscopic, immunological and treatment-related data from 432 consecutive SSc patients were retrospectively analyzed...
March 8, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28286109/bullous-pemphigoid
#2
REVIEW
Işın Sinem Bağcı, Orsolya N Horváth, Thomas Ruzicka, Miklós Sárdy
Bullous pemphigoid (BP) is the most common autoimmune bullous disorder which is characterized by autoantibodies against hemidesmosomal proteins of the skin and mucous membranes. Collagen XVII and dystonin-e have been identified as target antigens. BP affects mostly the elderly. The incidence of the disease is increasing gradually and is associated with high morbidity and mortality. Clinically, BP is characterized by an intensely pruritic eruption with widespread bullous lesions. The clinical diagnosis can be challenging in the setting of atypical presentations...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28286108/international-therapeutic-guidelines-for-patients-with-hcv-related-extrahepatic-disorders-a-multidisciplinary-expert-statement
#3
REVIEW
Anna Linda Zignego, Manuel Ramos-Casals, Clodoveo Ferri, David Saadoun, Luca Arcaini, Dario Roccatello, Alessandro Antonelli, Anne Claire Desbois, Cloe Commarmond, Laura Gragnani, Milvia Casato, Peter Lamprecht, Alessandra Mangia, Athanasios G Tzioufas, Zobair M Younossi, Patrice Cacoub
Hepatitis C virus (HCV) is both hepatotrophic and lymphotropic virus that causes liver as well extrahepatic manifestations including cryoglobulinemic vasculitis, the most frequent and studied condition, lymphoma, and neurologic, cardiovascular, endocrine-metabolic or renal diseases. HCV-extrahepatic manifestations (HCV-EHMs) may severely affect the overall prognosis, while viral eradication significantly reduces non-liver related deaths. Different clinical manifestations may coexist in the same patient. Due to the variety of HCV clinical manifestations, a multidisciplinary approach along with appropriate therapeutic strategies are required...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28286107/streptococcus-mutans-antigen-i-ii-and-autoimmunity-in-cardiovascular-diseases
#4
REVIEW
Alberta Lucchese
Infectious pathogens from the oral cavity cause oral diseases such as caries, gingivitis, periodontitis, endodontic infections, and alveolar osteitis, and often are also concomitant to systemic diseases, including cardiovascular disorders, stroke, preterm birth, diabetes, and pneumonia, among others. The relationship(s) between oral infections and systemic diseases are still unclear. Using the bacterial cell surface antigen I/II from S. mutans and cardiovascular diseases as a model, this study analyzes peptide commonalities that might underlie autoimmune crossreactions between the bacterial antigen and human proteins associated with cardiovascular disorders...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28286106/regulatory-immune-cells-and-functions-in-autoimmunity-and-transplantation-immunology
#5
REVIEW
Gabor Papp, Peter Boros, Britt Nakken, Peter Szodoray, Margit Zeher
In physiological circumstances, various tolerogenic mechanisms support the protection of self-structures during immune responses. However, quantitative and/or qualitative changes in regulatory immune cells and mediators can evoke auto-reactive immune responses, and upon susceptible genetic background, along with the presence of other concomitant etiological factors, autoimmune disease may develop. In transplant immunology, tolerogenic mechanisms are also critical, since the balance between of alloantigen-reactive effector cells and the regulatory immune cells will ultimately determine whether a graft is accepted or rejected...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28286105/animal-models-in-idiopathic-inflammatory-myopathies-how-to-overcome-a-translational-roadblock
#6
REVIEW
Ali Maisam Afzali, Tobias Ruck, Heinz Wiendl, Sven G Meuth
Idiopathic inflammatory myopathies (IIMs) encompass a heterogenic group of rare muscle diseases with common symptoms including muscle weakness and the presence of certain histological features. Since the pathogenesis remains unclear, therapeutic approaches in general comprise unspecific immunosuppression strategies that have been met with limited success. Therefore, a deeper understanding of the underlying pathophysiological mechanisms is critically required to assist in development of targeted therapies. Animal models have proven to be tremendously helpful in mechanistic studies and allow researchers to overcome the inevitable restrictions of human research...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28279839/comorbid-association-of-antiphospholipid-antibodies-and-migraine-a-systematic-review-and-meta-analysis
#7
REVIEW
Md Asiful Islam, Fahmida Alam, Kah Keng Wong
BACKGROUND: Antiphospholipid antibodies (aPLs) namely anticardiolipin (aCL) antibody, anti-β2-glycoprotein I (β2GPI) antibody and lupus anticoagulant (LA) are autoantibodies produced against anionic phospholipids and proteins on plasma membranes. Migraine is a primary headache disorder which has growing evidences of autoimmune-mediated pathogenesis and previous studies suggested the presence of aPLs in migraine patients. AIMS: The aim of this study was to evaluate the comorbid association between aPLs (aCL, anti-β2GPI and LA) and migraine compared to healthy controls...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28279837/relevance-of-diagnostic-investigations-in-patients-with-uveitis-retrospective-cohort-study-on-300-patients
#8
REVIEW
Jérôme Hadjadj, Agnès Dechartres, Thibaut Chapron, Manal Assala, Sawsen Salah, Bertrand Dunogué, Lucile Musset, Bruno Baudin, Matthieu Groh, Philippe Blanche, Luc Mouthon, Dominique Monnet, Claire Le Jeunne, Antoine Brézin, Benjamin Terrier
OBJECTIVE: The diagnostic workup of uveitis is a challenge due to the wide range of diagnoses and the lack of a well-codified diagnostic procedure. We aimed to evaluate the relevance of diagnostic investigations for the etiological diagnosis of uveitis. METHODS: Retrospective cohort study of patients referred for etiological diagnosis of uveitis. Uveitis related to ophthalmological diseases or occurring during the course of previously diagnosed diseases were not included...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28279836/autologous-hematopoietic-stem-cell-transplantation-in-systemic-lupus-erythematosus-and-antiphospholipid-syndrome-a-systematic-review
#9
REVIEW
Alessia Leone, Massimo Radin, Ahlam M Almarzooqi, Jamal Al-Saleh, Dario Roccatello, Savino Sciascia, Munther Khamashta
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) has been proposed as a therapeutic option for patients with Systemic Lupus Erythematosus (SLE) refractory to standard therapy. This therapeutic approach has been applied to other severe autoimmune diseases refractory to standard therapy with promising results. AIM: To systematically review the literature and analyze the available evidence on HSCT therapy in patients with SLE and antiphospholipid syndrome (APS), with a focus on therapy efficacy and occurrence of adverse events...
March 7, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28279841/european-multicentre-pilot-survey-to-assess-vitamin-d-status-in-rheumatoid-arthritis-patients-and-early-development-of-a-new-patient-reported-outcome-questionnaire-d-pro
#10
REVIEW
Jelena Vojinovic, Angela Tincani, Alberto Sulli, Stefano Soldano, Laura Andreoli, Francesca Dall'Ara, Ruxandra Ionescu, Katarina Simic Pasalic, Inete Balcune, Ivan Ferraz-Amaro, Małgorzata Tlustochowicz, Irena Butrimiene, Egle Punceviciene, Natalia Toroptsova, Simeon Grazio, Jadranka Morovic-Vergles, Pavol Masaryk, Kati Otsa, Miguel Bernardes, Vladimira Boyadzhieva, Fausto Salaffi, Maurizio Cutolo
OBJECTIVE: To collect data on vitamin D (25(OH)D) serum levels in a large number of rheumatoid arthritis (RA) patients from different European countries, to investigate their relation with disease activity, disability, quality of life, and possibly to construct a new Patient Reported Outcome (PRO) questionnaire in order to self-estimate if they are at risk for vitamin D insufficiency/deficiency-related clinical implications (D-PRO). METHODS: This was a European League Against Rheumatism (EULAR) supported cross-sectional study (project No CLI064) which involved 625 RA patients (mean age 55±11 years, mean disease duration 11±9 years), 276 age and sex matched healthy subjects, and rheumatologists working in academic institutions or hospital centres, as well as PARE organizations (patient representatives) from 13 European countries...
March 6, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28279840/the-utility-of-monitoring-peripheral-blood-lymphocyte-subsets-by-flow-cytometric-analysis-in-patients-with-rheumatological-diseases-treated-with-rituximab
#11
REVIEW
Jessica Day, Vidya Limaye, Susanna Proudman, John D Hayball, Pravin Hissaria
No abstract text is available yet for this article.
March 6, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28279838/modulation-of-sphingosine-1-phosphate-in-inflammatory-bowel-disease
#12
REVIEW
Laurent Peyrin-Biroulet, Ronald Christopher, Dominic Behan, Cheryl Lassen
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, involve an inappropriate immune reaction in the digestive tract, causing a variety of disabling symptoms. The advent of monoclonal antibodies (anti-tumor necrosis factor, anti-integrin, anti-interleukin -23) has revolutionized IBD management. Nevertheless, these agents, with potential for immunogenicity, are associated with high rates of response loss and disease relapse over time. They are also associated with high production costs...
March 6, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28212923/multiple-sclerosis-in-the-real-world-a-systematic-review-of-fingolimod-as-a-case-study
#13
REVIEW
Tjalf Ziemssen, Jennie Medin, C Anne-Marie Couto, Catherine R Mitchell
INTRODUCTION: The aim of our study was to systematically review the growing body of published literature reporting on one specific multiple sclerosis (MS) treatment, fingolimod, in the real world to assess its effectiveness in patients with MS, evaluate methodologies used to investigate MS in clinical practice, and describe the evidence gaps for MS as exemplified by fingolimod. METHODS: We conducted a PRISMA-compliant systematic review of the literature (cut-off date: 4 March 2016)...
February 15, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28232169/cogan-s-syndrome-state-of-the-art-of-systemic-immunosuppressive-treatment-in-adult-and-pediatric-patients
#14
REVIEW
Paolo Mora, Giacomo Calzetti, S Ghirardini, P Rubino, S Gandolfi, J Orsoni
OBJECTIVE: The aim of this study was to systematically evaluate the evidences for treatment of Cogan's syndrome (CS), with reference to adult and younger patients described in the literature. SYSTEMATIC REVIEW METHODOLOGY: DATA SOURCES: Studies reviewed were English language original articles ranging from 1990 to 2016 reporting data for subjects with CS (typical and atypical) undergoing any systemic treatment other than steroids alone. Medline/EMBASE, Cochrane Library were searched...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28212924/ibd-immunopathogenesis-a-comprehensive-review-of-inflammatory-molecules
#15
REVIEW
Jae Hyon Park, Laurent Peyrin-Biroulet, Michael Eisenhut, Jae Il Shin
Inflammatory molecules play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn's disease, both of which are chronic inflammatory conditions of the gastrointestinal tract. Abnormal expressions of pro-and anti-inflammatory molecules have been described to cause an imbalance to the gut innate and adaptive immunity, and recently a large portion of research in IBD has been geared towards identifying novel molecules that may be used as potential therapeutic targets...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28212922/organ-specific-biomarkers-in-lupus
#16
REVIEW
Haijing Wu, Jinrong Zeng, Jinghua Yin, Qiao Peng, Ming Zhao, Qianjin Lu
Systemic lupus erythematosus (SLE) is a complex and highly heterogeneous disease, which affects multiple organs, including joints, skin, kidneys, heart, hematopoietic system, and nerve system. While the etiopathogenesis of SLE still remains unclear, genetic susceptibilities and aberrant epigenetic modifications are believed to be involved. For precision therapy, it is necessary to assess accurately and objectively organ involvements and disease activity, which is difficult by current clinical laboratory tests...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28212921/towards-developing-criteria-for-scleroderma-renal-crisis-a-scoping-review
#17
REVIEW
Sabrina Hoa, Edward P Stern, Christopher P Denton, Marie Hudson
OBJECTIVE: The absence of a gold standard for scleroderma renal crisis (SRC) has hindered our understanding of this problem. The objective of this scoping review was to identify the criteria used to define SRC in order to guide the development of a consensus definition for SRC. METHODS: We conducted a search in three databases: Medline, Embase and non-Ovid Pubmed. Papers were eligible for inclusion if they were full-length articles in English whose main topic was SRC or scleroderma renal disease...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28212920/neonatal-lupus-follow-up-in-infants-with-anti-ssa-ro-antibodies-and-review-of-the-literature
#18
REVIEW
Antonio Alberto Zuppa, Riccardo Riccardi, Simonetta Frezza, Francesca Gallini, Rita Maria Paola Luciano, Giovanni Alighieri, Costantino Romagnoli, Sara De Carolis
Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28232168/molecular-analysis-of-vascular-smooth-muscle-cells-from-patients-with-giant-cell-arteritis-targeting-endothelin-1-receptor-to-control-proliferation
#19
REVIEW
Alexis Régent, Kim Heang Ly, Matthieu Groh, Chabha Khifer, Sébastien Lofek, Guilhem Clary, Philippe Chafey, Véronique Baud, Cédric Broussard, Christian Federici, François Labrousse, Laura Mesturoux, Claire Le Jeunne, Elisabeth Vidal, Antoine Brezin, Véronique Witko-Sarsat, Loïc Guillevin, Luc Mouthon
OBJECTIVE: The pathophysiology of giant cell arteritis (GCA) and the mechanisms underlying vascular remodeling, are poorly understood. We aimed to compare vascular smooth muscle cells (VSMCs) from patients with GCA and controls by a proteomic and gene expression profile approach and to identify the signaling pathways involved in proliferation. METHODS: VSMCs were cultured from temporal artery biopsies (TABs) from patients with biopsy-proven GCA (TAB(+)-GCA), biopsy-negative GCA (TAB(-)-GCA), and diagnosis other than GCA (GCA-control)...
February 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28232167/intravenous-immunoglobulins-in-systemic-sclerosis-data-from-a-french-nationwide-cohort-of-46-patients-and-review-of-the-literature
#20
REVIEW
Sébastien Sanges, Sébastien Rivière, Arsène Mekinian, Thierry Martin, Alain Le Quellec, Emmanuel Chatelus, Alain Lescoat, Patrick Jego, Claire Cazalets, Thomas Quéméneur, Noémie Le Gouellec, Patricia Senet, Camille Francès, Alban Deroux, Bernard Imbert, Olivier Fain, Latifatou Boukari, Thomas Sené, Christophe Deligny, Alexis Mathian, Christian Agard, Grégory Pugnet, Silvia Speca, Sylvain Dubucquoi, Pierre-Yves Hatron, Éric Hachulla, David Launay
BACKGROUND: As intravenous immunoglobulins (IVIG) exhibit immunomodulatory and antifibrotic properties, they may be a relevant treatment for systemic sclerosis (SSc). The objectives of this work were thus to report on the efficacy and safety of IVIG in a population of SSc patients and to review the available literature. METHODS: 46 patients from 19 French centers were retrospectively recruited. They were included if they had a diagnosis of SSc and received at least 1 IVIG infusion at a dosage >1g/kg/cycle...
February 13, 2017: Autoimmunity Reviews
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