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Autoimmunity Reviews

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https://www.readbyqxmd.com/read/28918161/clinical-and-pathological-significance-of-cutaneous-manifestations-in-anca-associated-vasculitides
#1
REVIEW
Laure Frumholtz, Sara Laurent-Roussel, Olivier Aumaître, François Maurier, Guillaume Le Guenno, Agnes Carlotti, Alexiane Dallot, Jean Louis Kemeny, Laurent Antunes, Nicolas Froment, Sylvie Fraitag, Jonathan London, Alice Berezne, Benoît Terris, Claire Le Jeunne, Luc Mouthon, Selim Aractingi, Loïc Guillevin, Nicolas Dupin, Benjamin Terrier
OBJECTIVES: Cutaneous manifestations (CM) in ANCA-associated vasculitides (AAV) are frequent, but data on clinical significance and clinical-pathological correlations are lacking. METHODS: We conducted a multicenter, retrospective study including 1553 AAV patients. Clinical, biological and pathological features have been analyzed, and tissue samples from 46 biopsies were reviewed in a blind manner. RESULTS: CM were more frequent in EGPA (53...
September 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28919456/unresolved-and-critical-issues-in-autoimmune-rheumatic-diseases
#2
EDITORIAL
Andrea Doria, Mariele Gatto, Luca Iaccarino, Piercarlo Sarzi-Puttini
No abstract text is available yet for this article.
September 12, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28911988/primary-thromboprophylaxis-with-low-dose-aspirin-and-antiphospholipid-antibodies-pro-s-and-con-s
#3
REVIEW
Laurent Arnaud, Fabrizio Conti, François Chasset, Laura Massaro, Gentian Denas, Francois Chasset, Vittorio Pengo
Whether primary prophylaxis should be prescribed in individuals with antiphospholipid antibodies (aPL) remains controversial due to the lack of relevant evidence-based data. Indeed, it is unclear whether the benefit of LDA outweighs the risk of major bleeding associated LDA in a low-risk population. On the contrary, stratification of aPL-positive subjects according to their aPL profile (combination, isotype and titer), presence of other concomitant risk factors for thrombosis and coexistence of an underling autoimmune disease is essential to decide whether primary prophylactic therapy should be prescribed...
September 11, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28911987/aortitis-in-giant-cell-arteritis-diagnosis-with-fdg-pet-ct-and-agreement-with-ct-angiography
#4
REVIEW
Mona Hommada, Arsène Mekinian, Pierre-Yves Brillet, Sébastien Abad, Claire Larroche, Robin Dhôte, Olivier Fain, Michael Soussan
OBJECTIVES: To assess the detection rate of aortitis in giant cell arteritis (GCA) with fluorodeoxyglucose positron emission tomography/computed tomography (PET) and to compare the findings with CT angiography (CTA). METHODS: Fifty-two GCA patients and 27 controls were included. GCA patients had a PET scan at diagnosis (35/52) or during relapse (17/52). Concomitant CTA was performed in 35/52 patients. Aortitis was defined as FDG uptake higher than the liver for PET and wall thickness≥3mm for CTA...
September 11, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899804/can-we-withdraw-anticoagulation-in-patients-with-antiphospholipid-syndrome-after-seroconvertion
#5
REVIEW
S Sciascia, E Coloma-Bazán, M Radin, M L Bertolaccini, C López-Pedrera, Gerard Espinosa, P L Meroni, R Cervera, M J Cuadrado
The current mainstay of treatment in patients with thrombotic antiphospholipid syndrome (APS) is long-term anticoagulation, mainly with Vitamin K antagonist agents. Some recently available studies have created new ground for discussion about the possible discontinuation of anticoagulation therapy in patients with a history of thrombotic APS in whom antiphospholipid antibodies (aPL) are not detected any longer (i.e. aPL seroconversion). We report the main points discussed at the last CORA Meeting regarding the issue whether or not anticoagulation can be stopped after aPL seroconversion...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899803/humanistic-and-cost-burden-of-systemic-sclerosis-a-review-of-the-literature
#6
REVIEW
Aryeh Fischer, Evelina Zimovetz, Caroline Ling, Dirk Esser, Nils Schoof
BACKGROUND: Systemic sclerosis (SSc), or systemic scleroderma, is a chronic multisystem autoimmune disease characterised by widespread vascular injury and progressive fibrosis of the skin and internal organs. Patients with SSc have decreased survival, with pulmonary involvement as the main cause of death. Current treatments for SSc manage a range of symptoms but not the cause of the disease. Our review describes the humanistic and cost burden of SSc. METHODS: A structured review of the literature was conducted, using predefined search strategies to search PubMed, Embase, and the Cochrane Library...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899802/the-new-targeted-therapy-in-systemic-lupus-erythematosus-is-the-glass-half-full-or-half-empty
#7
REVIEW
Andrea Doria, Ricard Cervera, Mariele Gatto, Gamal Chehab, Matthias Schneider
Biologic therapy is still limited in lupus, where chronic steroid exposure and wide-spectrum immunosuppression are major triggers of organ damage. In this viewpoint, the authors summarize their views for a "half-full or half-empty" glass on targeted therapy in SLE. The are several reasons for seeing the glass half-empty and in this section the authors propose a critical reflection on scarceness of novel targeted lupus therapies. They show how hard it is to identify suitable biological and clinical targets and to choose the patients that may best fit those targets, as well as to stratify patients according to disease subtype and response, all contributing to the final outcome...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899801/is-pet-ct-essential-in-the-diagnosis-and-follow-up-of-temporal-arteritis
#8
REVIEW
Carlo Salvarani, Alessandra Soriano, Francesco Muratore, Yehuda Shoenfeld, Daniel Blockmans
The increasing availability and improvement of imaging techniques are deeply influencing diagnosis and work-up of patients affected with vasculitis, particularly those with large vessel vasculitis (LVV). Fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET), especially when integrated with computed tomography (CT), is taking hold as a useful diagnostic technique to examine the aorta and the other large vessels in giant cell arteritis (GCA) with concomitant large vessel involvement (LV-GCA). In this paper we examined the progresses performed in this field in the last twenty years and the evidence available so far according to two different points of view ('pros' and 'cons'), in order to give a comprehensive answer to a still open question about the role of PET/CT in the diagnosis and follow-up of GCA...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899800/bone-mineral-density-and-vitamin-d-status-in-systemic-lupus-erythematosus-sle-a-systematic-review
#9
REVIEW
Tarek Carlos Salman-Monte, Vicenç Torrente-Segarra, Ana Leticia Vega Vidal, Patricia Corzo, F Castro-Dominguez, F Ojeda, Jordi Carbonell Abelló
Despite the improvement in the quality of life of patients with SLE due to scientific and technological advances, SLE remains a disease that over the years may produce irreversible damage to patients. Osteoporosis and secondary bone fractures are two of the major causes of irreparable injury in patients with SLE. Vitamin D insufficiency may play a vital role both in reduced Bone Mineral Density (BMD) and in the appearance of fractures, although its mechanisms of action are still unclear. We performed a systematic review of the literature in order to determine the prevalence and predictors of reduced vitamin D plasma levels, bone loss and the presence of fractures in SLE patients...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899799/neutrophil-extracellular-traps-nets-in-autoimmune-diseases-a-comprehensive-review
#10
REVIEW
Keum Hwa Lee, Andreas Kronbichler, David Duck-Young Park, YoungMin Park, Hanwool Moon, Hyungdo Kim, Jun Hyug Choi, YoungSeo Choi, Songjoo Shim, Il Suk Lyu, Byung Hwan Yun, Yeonseung Han, Donghee Lee, Sang Yoon Lee, Byung Hun Yoo, Kyung Hwan Lee, Tai Lim Kim, Heonki Kim, Joo Sung Shim, Wonseok Nam, Heesung So, SooYeon Choi, Sangmok Lee, Jae Il Shin
The structures named neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membrane of activated neutrophils. NETs are found in a variety of conditions, such as infection, malignancy, atherosclerosis, and autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. The impact of NETs on the development mechanisms of autoimmune diseases are proposed to arise from an imbalance between "NETosis" which is a process of NET formation and NET degradation...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899798/is-acpa-positivity-the-main-driver-for-rheumatoid-arthritis-treatment-pros-and-cons
#11
REVIEW
Stefano Alivernini, Mauro Galeazzi, Hagit Peleg, Barbara Tolusso, Elisa Gremese, Gianfranco Ferraccioli, Yaakov Naparstek
Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared to seronegative RA. Moreover, ACPA status is associated with favorable response to biologics targeting pathways involving autoantibody producing cells as B lymphocytes...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28899797/should-we-treat-congenital-heart-block-with-fluorinated-corticosteroids
#12
REVIEW
Antonio Brucato, Angela Tincani, Micaela Fredi, Silvia Breda, Veronique Ramoni, Nathalie Morel, Nathalie Costedoat-Chalumeau
No abstract text is available yet for this article.
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28780080/-how-i-treat-autoimmune-diseases-state-of-the-art-on-the-management-of-rare-rheumatic-diseases-and-anca-associated-systemic-idiopathic-vasculitis
#13
EDITORIAL
Dario Roccatello
This Special Issue of Autoimmunity Reviews constitutes summaries of presentations at the 20th International Meeting on Immunopathology and Orphan Diseases, held in Torino, Italy, 25-28th January 2017. As such, these presentations represent the state of the art on the pathophysiology of autoimmune diseases as well as the most recent insights into the management of these pathologic conditions. The latter includes both the optimal use of established drugs and approaches as well as novel knowledge on the means and consequences of targeted blocking of molecules or cellular mechanisms...
August 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28780079/antineutrophil-cytoplasmic-antibody-associated-vasculitides-and-igg4-related-disease-a-new-overlap-syndrome
#14
REVIEW
François-Xavier Danlos, Giovanni Maria Rossi, Daniel Blockmans, Giacomo Emmi, Andreas Kronbichler, Stéphane Durupt, Claire Maynard, Luminita Luca, Cyril Garrouste, Bertrand Lioger, Rachel Mourot-Cottet, Robin Dhote, Jean-Benoit Arlet, Thomas Hanslik, Philippe Rouvier, Mikael Ebbo, Xavier Puéchal, Dominique Nochy, Agnès Carlotti, Luc Mouthon, Loïc Guillevin, Augusto Vaglio, Benjamin Terrier
OBJECTIVE: Atypical manifestations have been described in patients with ANCA-associated vasculitides (AAV), such as pachymeningitis, orbital mass or chronic periaortitis. Because these manifestations have been associated to the spectrum of IgG4-related disease (IgG4-RD), we hypothesized that both diseases could overlap. METHODS: We conducted a European retrospective multicenter observational study including patients fulfilling ACR and Chapel Hill criteria for AAV and IgG4-RD Comprehensive Diagnostic Criteria...
August 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28778711/are-cytokines-and-chemokines-suitable-biomarkers-for-takayasu-arteritis
#15
REVIEW
Bruna Savioli, Wayel H Abdulahad, Elisabeth Brouwer, Cees G M Kallenberg, Alexandre Wagner Silva de Souza
There is a growing need for disease related biomarkers in Takayasu arteritis (TA).The assessment of pro-inflammatory cytokines and chemokines in TA may provide a better understanding of its pathophysiology, and circulating levels of these mediators may act as biomarkers of disease activity. Serum level of interleukin 6 (IL-6) is a potential biomarker for TA, which is mostly associated with TA status and disease activity. Associations between TA and serum/plasma levels of other cytokines are less clear. mRNA expression of IL-4 and tumor necrosis factor α (TNFα) are constitutively increased in peripheral blood mononuclear cells (PBMC) from TA patients and the expression of both cytokines increases even more after PBMC stimulation in vitro, while the expression of IL-10 mRNA decreases...
August 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28778708/the-yin-and-yang-of-regulatory-t-cell-and-therapy-progress-in-autoimmune-disease
#16
REVIEW
Yong-Chao Qiao, Yan-Hong Pan, Wei Ling, Fang Tian, Yin-Ling Chen, Xiao-Xi Zhang, Hai-Lu Zhao
Autoimmune diseases (ADs) are primarily mediated by the failure of immunological self-tolerance. Regulatory T cells (Tregs) play a critical role in the maintenance of induced tolerance to peripheral self-antigens, suppressing immoderate immune responses deleterious to the host and preventing the AD development. Tregs and suppressive cytokines are homeostatic with effective cells plus pro-inflammatory cytokines in healthy hosts which is defined as "Yang", and ADs are usually induced in case of disturbed homeostasis, which is defined as "Yin"...
August 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28778705/targeting-interleukin-6-in-autoimmune-uveitis
#17
REVIEW
Marina Mesquida, Blanca Molins, Víctor Llorenç, Maite Sáinz de la Maza, Alfredo Adán
Interleukin-6 (IL-6) is a key cytokine that is strongly up-regulated during infection and inflammation. Featuring pleiotropic activity, IL-6 is responsible for the induction of hepatic acute-phase proteins, trafficking of acute and chronic inflammatory cells, differentiation of adaptive T cell responses, homeostatic regulation, and tissue regeneration. Dysregulated IL-6 production has been associated with the development of a wide variety of systemic immune-mediated, chronic diseases, and even certain types of cancer...
August 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28778704/how-i-treat-idiopathic-patients-with-inflammatory-myopathies-in-the-clinical-practice
#18
REVIEW
Lorenzo Cavagna, Sara Monti, Roberto Caporali, Mariele Gatto, Luca Iaccarino, Andrea Doria
Management of patients with idiopathic inflammatory myopathies (IIMs) is challenging given the systemic nature of the disease, which is often complicated by potentially life-threatening manifestations and the lack of standardized treatment regimens. Aim of this review is to provide the currently available evidence for immunotherapy in the treatment of various manifestations of IIM in order to help clinicians in the daily management of these patients.
August 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28778703/fetal-sequential-multiorgan-autoimmunity-associated-with-recurrent-post-thymectomy-thymoma
#19
LETTER
Ze-Hu Liu, Jun-Zhu Xu, Hong Shen
No abstract text is available yet for this article.
August 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28778710/how-i-treat-patients-with-systemic-sclerosis-in-clinical-practice
#20
REVIEW
Daniela Rossi, Elisabetta Zanatta, Piero Marson, Savino Sciascia, Pamela Polito, Dario Roccatello, Franco Cozzi
Systemic sclerosis (SSc) or scleroderma is a disorder of the connective tissue affecting the skin, and it is often associated with visceral involvement. The predominant pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. Progressive fibrosis is associated with changes in the microcirculation of the involved organs. Here, we review the clinical features of systemic sclerosis and describe the best practice approaches for its management, reviewing available guidelines and recommendations and providing experts' insights...
August 1, 2017: Autoimmunity Reviews
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