journal
MENU ▼
Read by QxMD icon Read
search

Lab on a Chip

journal
https://www.readbyqxmd.com/read/28426092/correction-high-precision-localized-proton-gradients-and-fluxes-generated-by-a-microelectrode-device-induce-differential-growth-behaviors-of-pollen-tubes
#1
Chengzhi Hu, Hannes Vogler, Marianne Aellen, Naveen Shamsudhin, Bumjin Jang, Jan T Burri, Nino Läubli, Ueli Grossniklaus, Salvador Pané, Bradley J Nelson
Correction for 'High precision, localized proton gradients and fluxes generated by a microelectrode device induce differential growth behaviors of pollen tubes' by Chengzhi Hu et al., Lab Chip, 2017, 17, 671-680.
April 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28426080/c-reactive-protein-and-interleukin-6-microfluidic-immunoassays-with-on-chip-pre-stored-reagents-and-centrifugo-pneumatic-liquid-control
#2
Y Zhao, G Czilwik, V Klein, K Mitsakakis, R Zengerle, N Paust
We present a fully automated centrifugal microfluidic method for particle based protein immunoassays. Stick-pack technology is employed for pre-storage and release of liquid reagents. Quantitative layout of centrifugo-pneumatic particle handling, including timed valving, switching and pumping is assisted by network simulations. The automation is exclusively controlled by the spinning frequency and does not require any additional means. New centrifugal microfluidic process chains are developed in order to sequentially supply wash buffer based on frequency dependent stick-pack opening and pneumatic pumping to perform two washing steps from one stored wash buffer; pre-store and re-suspend functionalized microparticles on a disk; and switch between the path of the waste fluid and the path of the substrate reaction product with 100% efficiency...
April 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28426078/an-intravascular-bioartificial-pancreas-device-ibap-with-silicon-nanopore-membranes-snm-for-islet-encapsulation-under-convective-mass-transport
#3
Shang Song, Charles Blaha, Willieford Moses, Jaehyun Park, Nathan Wright, Joey Groszek, William Fissell, Shant Vartanian, Andrew M Posselt, Shuvo Roy
Diffusion-based bioartificial pancreas (BAP) devices are limited by poor islet viability and functionality due to inadequate mass transfer resulting in islet hypoxia and delayed glucose-insulin kinetics. While intravascular ultrafiltration-based BAP devices possess enhanced glucose-insulin kinetics, the polymer membranes used in these devices provide inadequate ultrafiltrate flow rates and result in excessive thrombosis. Here, we report the silicon nanopore membrane (SNM), which exhibits a greater hydraulic permeability and a superior pore size selectivity compared to polymer membranes for use in BAP applications...
April 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28426055/droplet-manipulation-on-a-structured-shape-memory-polymer-surface
#4
Jun Kyu Park, Seok Kim
While methods for dynamic tuning of surface wettability to manipulate water droplets have been widely explored for many applications including digital microfluidics, those based on dynamically changeable surface morphology have remained challenging to achieve. In this work, we present a structured shape memory polymer (SMP) surface which shows dynamically tunable surface wettability through changeable surface morphology in order to manipulate water droplets. The structured SMP surface involves a SMP pillar array consisting of nanotextured small and large pillars which can change its morphology between permanent and temporary shapes upon thermomechanical loading...
April 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28418438/a-scalable-self-priming-fractal-branching-microchannel-net-chip-for-digital-pcr
#5
Qiangyuan Zhu, Yanan Xu, Lin Qiu, Congcong Ma, Bingwen Yu, Qi Song, Wei Jin, Qinhan Jin, Jinyu Liu, Ying Mu
As an absolute quantification method at the single-molecule level, digital PCR has been widely used in many bioresearch fields, such as next generation sequencing, single cell analysis, gene editing detection and so on. However, existing digital PCR methods still have some disadvantages, including high cost, sample loss, and complicated operation. In this work, we develop an exquisite scalable self-priming fractal branching microchannel net digital PCR chip. This chip with a special design inspired by natural fractal-tree systems has an even distribution and 100% compartmentalization of the sample without any sample loss, which is not available in existing chip-based digital PCR methods...
April 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28418430/wat-on-a-chip-a-physiologically-relevant-microfluidic-system-incorporating-white-adipose-tissue
#6
Peter Loskill, Thiagarajan Sezhian, Kevin M Tharp, Felipe T Lee-Montiel, Shaheen Jeeawoody, Willie Mae Reese, Peter-James H Zushin, Andreas Stahl, Kevin E Healy
Organ-on-a-chip systems possess a promising future as drug screening assays and as testbeds for disease modeling in the context of both single-organ systems and multi-organ-chips. Although it comprises approximately one fourth of the body weight of a healthy human, an organ frequently overlooked in this context is white adipose tissue (WAT). WAT-on-a-chip systems are required to create safety profiles of a large number of drugs due to their interactions with adipose tissue and other organs via paracrine signals, fatty acid release, and drug levels through sequestration...
April 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28418422/a-disease-model-of-diabetic-nephropathy-in-a-glomerulus-on-a-chip-microdevice
#7
Li Wang, Tingting Tao, Wentao Su, Hao Yu, Yue Yu, Jianhua Qin
Diabetic nephropathy is a major chronic renal complication of diabetes mellitus, and is the leading cause of end-stage kidney diseases. Establishing a disease model of diabetic nephropathy in vitro can accelerate the understanding of its mechanisms and pharmaceutical development. We provide the proof-of-principle for using a glomerulus-on-a-chip microdevice that reconstitutes organ-level kidney functions to create a human disease model of early stage diabetic nephropathy on chip. The microfluidic device, which recapitulates the glomerular microenvironment, consists of parallel channels lined by isolated primary glomerular microtissues that experience fluid flow to mimic the glomerular filtration barrier (GFB), including glomerular endothelial cells, 3D basement membrane and podocytes...
April 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28406508/integration-of-digital-microfluidics-with-whispering-gallery-mode-sensors-for-label-free-detection-of-biomolecules
#8
Sentayehu F Wondimu, Sebastian von der Ecken, Ralf Ahrens, Wolfgang Freude, Andreas E Guber, Christian Koos
We present a multi-sensor chip comprising an array of whispering-gallery mode (WGM) micro-goblet lasers integrated into a digital microfluidic (DMF) system. In contrast to earlier demonstrations, the lasers are fabricated from dye-doped poly-methyl methacrylate (PMMA) at low cost using spin-coating, mask-based optical lithography, wet chemical etching, and thermal reflow techniques. Pumping and read-out of the devices is accomplished via simple free-space optics, thereby allowing large-scale sensor arrays to be addressed...
April 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28401229/microengineered-biomimetic-ocular-models-for-ophthalmological-drug-development
#9
REVIEW
Zachary Estlack, Devasier Bennet, Ted Reid, Jungkyu Kim
Current ophthalmological drug discovery and testing methods have limitations and concerns regarding reliability, ethicality, and applicability. These drawbacks can be mitigated by developing biomimetic eye models through mathematical and experimental methods which are often referred to as "eye-on-a-chip" or "eye chip". These eye chip technologies emulate ocular physiology, anatomy, and microenvironmental conditions. Such models enable understanding of the fundamental biology, pharmacology, and toxicology mechanisms by investigating the pharmacokinetics and pharmacodynamics of various candidate drugs under ocular anatomical and physiological conditions without animal models...
April 12, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28401227/in-situ-mrna-isolation-from-a-microfluidic-single-cell-array-using-an-external-afm-nanoprobe
#10
Xuan Li, Yinglei Tao, Do-Hyun Lee, Hemantha K Wickramasinghe, Abraham P Lee
We present an in situ mRNA extraction platform to quantify marker-genes' expression levels of single target cells within high-density microfluidic trapping arrays. This platform enables single-cell transcriptomic analysis to reveal in-depth information of cellular mechanisms and population heterogeneity. Although microfluidic technology enables the automation of single-cell sorting, trapping and identification, most developed microfluidic devices are closed off and prevent single-cell access by external analytical equipment...
April 12, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28396895/multi-chamber-microfluidic-platform-for-high-precision-skin-permeation-testing
#11
M Alberti, Y Dancik, G Sriram, B Wu, Y L Teo, Z Feng, M Bigliardi-Qi, R G Wu, Z P Wang, P L Bigliardi
The established in vitro tool used for testing the absorption and penetration of chemicals through skin in pharmacology, toxicology and cosmetic science is the static Franz diffusion cell. While widespread, Franz cells are relatively costly, low-throughput and results may suffer from poor reproducibility. Microfluidics has the potential to overcome these drawbacks. In this paper, we present a novel microfluidic skin permeation platform and validate it rigorously against the Franz cell by comparing the transport of 3 model chemicals of varying lipophilicity: caffeine, salicylic acid and testosterone...
April 11, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28394386/selective-particle-and-cell-capture-in-a-continuous-flow-using-micro-vortex-acoustic-streaming
#12
David J Collins, Bee Luan Khoo, Zhichao Ma, Andreas Winkler, Robert Weser, Hagen Schmidt, Jongyoon Han, Ye Ai
Acoustic streaming has emerged as a promising technique for refined microscale manipulation, where strong rotational flow can give rise to particle and cell capture. In contrast to hydrodynamically generated vortices, acoustic streaming is rapidly tunable, highly scalable and requires no external pressure source. Though streaming is typically ignored or minimized in most acoustofluidic systems that utilize other acoustofluidic effects, we maximize the effect of acoustic streaming in a continuous flow using a high-frequency (381 MHz), narrow-beam focused surface acoustic wave...
April 10, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28387775/synchrotron-ftir-mapping-of-mineralization-in-a-microfluidic-device
#13
Shunbo Li, Johannes Ihli, William J Marchant, Muling Zeng, Li Chen, Katia Wehbe, Gianfelice Cinque, Oscar Cespedes, Nik Kapur, Fiona C Meldrum
Fourier transform infrared micro-spectroscopy provides an effective means of performing rapid, non-destructive, and label-free analysis of specimens according to their vibrational modes. However, as water absorbs very strongly in the infrared region, analysis of aqueous solutions in transmission mode can suffer from problems with signal saturation. We here describe the fabrication of a novel microfluidic device that overcomes this problem. Devices with channel depths of just 3 μm were constructed from calcium fluoride using photolithography and hot embossing bonding, where calcium fluoride was selected due to its transparency in the IR region...
April 7, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28382356/magnetic-fluidized-bed-for-solid-phase-extraction-in-microfluidic-systems
#14
Iago Pereiro, Sanae Tabnaoui, Marc Fermigier, Olivia du Roure, Stéphanie Descroix, Jean-Louis Viovy, Laurent Malaquin
Fluidization, a process in which a granular solid phase behaves like a fluid under the influence of an imposed upward fluid flow, is routinely used in many chemical and biological engineering applications. It brings, to applications involving fluid-solid exchanges, advantages such as high surface to volume ratio, constant mixing, low flow resistance, continuous operation and high heat transfer. We present here the physics of a new miniaturized, microfluidic fluidized bed, in which gravity is replaced by a magnetic field created by an external permanent magnet, and the solid phase is composed of magnetic microbeads with diameters ranging from 1 to 5 μm...
April 6, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28379279/towards-a-personalized-approach-to-aromatase-inhibitor-therapy-a-digital-microfluidic-platform-for-rapid-analysis-of-estradiol-in-core-needle-biopsies
#15
Sara Abdulwahab, Alphonsus H C Ng, M Dean Chamberlain, Hend Ahmado, Lucy-Ann Behan, Hala Gomaa, Robert F Casper, Aaron R Wheeler
Despite advances in breast cancer prevention and treatment, variability in patient-response has revealed the need for a more "personalized" approach to medicine, in which treatments are tailored to each patient's biology. Motivated by this idea, we introduce a technique that allows for quantification of small-molecule analytes directly from core needle biopsy (CNB) tissue samples on a miniaturized platform. The new technique, powered by digital microfluidics, integrates tissue-liquid extraction and magnetic bead-based competitive immunoassay for quantification of estradiol in milligram-sized CNB samples...
April 5, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28379278/directly-embroidered-microtubes-for-fluid-transport-in-wearable-applications
#16
Rahim Rahimi, Wuyang Yu, Manuel Ochoa, Babak Ziaie
We demonstrate, for the first time, a facile and low-cost approach for integrating highly flexible and stretchable microfluidic channels into textile-based substrates. The integration of the microfluidics is accomplished by means of directly embroidering surface-functionalized micro-tubing in a zigzag/meander pattern and subsequently coating it with an elastomer for irreversible bonding. We show the utility of the embroidered micro-tubing by developing robust and stretchable drug-delivery and electronic devices...
April 5, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28379253/rapid-contrast-matching-by-microfluidic-sans
#17
Marco Adamo, Andreas S Poulos, Ruhina M Miller, Carlos G Lopez, Anne Martel, Lionel Porcar, João T Cabral
We report a microfluidic approach to perform small angle neutron scattering (SANS) measurements of contrast variation and matching, extensively employed in soft and biological matter research. We integrate a low scattering background microfluidic mixer and serpentine channel in a SANS beamline to yield a single phase, continuous flow, reconfigurable liquid cell. By contrast with conventional, sequential measurements of discrete (typically 4-6) solutions of varying isotopic solvent composition, our approach continually varies solution composition during SANS acquisition...
April 5, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28379223/in-vitro-nasal-mucosa-gland-like-structure-formation-on-a-chip
#18
Kyuhwan Na, Mingyu Lee, Hyun-Woo Shin, Seok Chung
The emergence of microfluidic epithelial models using diverse types of cells within a physiologically relevant microenvironment has the potential to be a powerful tool for preclinical drug screening and pathophysiological studies. However, to date, few studies have reported the development of a complicated in vitro human nasal epithelial model. The aim of this study was to produce an in vitro human nasal mucosa model for reliable drug screening and clinical applications. Here, we integrated and optimized several culture conditions such as cell type, airway culture conditions, and hydrogel scaffolds into a microfluidic chip to construct an advanced in vitro human nasal mucosa model...
April 5, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28357424/recognition-mediated-particle-detection-under-microfluidic-flow-with-waveguide-coupled-2d-photonic-crystals-towards-integrated-photonic-virus-detectors
#19
James E Baker, Rashmi Sriram, Benjamin L Miller
Label-free biodetection schemes compatible with standard CMOS fabrication methods constitute an important goal, as these are enabling tools for the mass production of high-sensitivity biosensors. Two-dimensional slab photonic crystal (2D slab-PhC) sensors have been posited as ultrahigh-sensitivity detection components, but to date recognition-mediated detection of viruses or simulants under flow has not been demonstrated. We report the design and optimization of a new W1 waveguide-coupled 2D slab-PhC sensor, with a geometry well suited to virus detection...
March 30, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28350018/frequency-tuning-allows-flow-direction-control-in-microfluidic-networks-with-passive-features
#20
Rahil Jain, Barry Lutz
Frequency tuning has emerged as an attractive alternative to conventional pumping techniques in microfluidics. Oscillating (AC) flow driven through a passive valve can be rectified to create steady (DC) flow, and tuning the excitation frequency to the characteristic (resonance) frequency of the underlying microfluidic network allows control of flow magnitude using simple hardware, such as an on-chip piezo buzzer. In this paper, we report that frequency tuning can also be used to control the direction (forward or backward) of the rectified DC flow in a single device...
March 28, 2017: Lab on a Chip
journal
journal
39871
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"