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Lab on a Chip

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https://www.readbyqxmd.com/read/28636050/photoelectrochemical-ion-concentration-polarization-membraneless-ion-filtration-based-on-light-driven-electrochemical-reactions
#1
Eunsoo Yoon, Collin D Davies, Tim A Hooper, Richard M Crooks
In this article we report a microelectrochemical system that is able to partially desalinate water. The underlying principles are similar to previous reports in which a local electric field resists passage of ions. However, in the present case, no membrane is required and, most interestingly, much of the power for desalination originates from light rather than electricity. This could greatly increase the power efficiency for desalination. The device is based on a TiO2 photoanode coupled to a Pt cathode. Illumination of the photoanode drives faradaic reactions at the cathode that lead to an ion depletion zone...
June 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28634603/high-resolution-and-multi-range-particle-separation-by-microscopic-vibration-in-an-optofluidic-chip
#2
Y Z Shi, S Xiong, L K Chin, Y Yang, J B Zhang, W Ser, J H Wu, T N Chen, Z C Yang, Y L Hao, B Liedberg, P H Yap, Y Zhang, A Q Liu
An optofluidic chip is demonstrated in experiments for high-resolution and multi-range particle separation through the optically-induced microscopic vibration effect, where nanoparticles are trapped in loosely overdamped optical potential wells created with combined optical and fluidic constraints. It is the first demonstration of separating single nanoparticles with diameters ranging from 60 to 100 nm with a resolution of 10 nm. Nanoparticles vibrate with an amplitude of 3-7 μm in the loosely overdamped potential wells in the microchannel...
June 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28632278/paper-microfluidics-for-nucleic-acid-amplification-testing-naat-of-infectious-diseases
#3
Laura Magro, Camille Escadafal, Pierre Garneret, Béatrice Jacquelin, Aurélia Kwasiborski, Jean-Claude Manuguerra, Fabrice Monti, Anavaj Sakuntabhai, Jessica Vanhomwegen, Pierre Lafaye, Patrick Tabeling
The diagnosis of infectious diseases is entering a new and interesting phase. Technologies based on paper microfluidics, coupled to developments in isothermal amplification of Nucleic Acids (NAs) raise opportunities for bringing the methods of molecular biology in the field, in a low setting environment. A lot of work has been performed in the domain over the last few years and the landscape of contributions is rich and diverse. Most often, the level of sample preparation differs, along with the sample nature, the amplification and detection methods, and the design of the device, among other features...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28632265/3d-printed-conformal-microfluidics-for-isolation-and-profiling-of-biomarkers-from-whole-organs
#4
Manjot Singh, Yuxin Tong, Kelly Webster, Ellen Cesewski, Alexander P Haring, Sahil Laheri, Bill Carswell, Timothy J O'Brien, Charles H Aardema, Ryan S Senger, John L Robertson, Blake N Johnson
The ability to interface microfluidic devices with native complex biological architectures, such as whole organs, has the potential to shift the paradigm for the study and analysis of biological tissue. Here, we show 3D printing can be used to fabricate bio-inspired conformal microfluidic devices that directly interface with the surface of whole organs. Structured-light scanning techniques enabled the 3D topographical matching of microfluidic device geometry to porcine kidney anatomy. Our studies show molecular species are spontaneously transferred from the organ cortex to the conformal microfluidic device in the presence of fluid flow through the organ-conforming microchannel...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28631799/droplet-control-technologies-for-microfluidic-high-throughput-screening-%C3%AE-hts
#5
REVIEW
Muhsincan Sesen, Tuncay Alan, Adrian Neild
The transition from micro well plate and robotics based high throughput screening (HTS) to chip based screening has already started. This transition promises reduced droplet volumes thereby decreasing the amount of fluids used in these studies. Moreover, it significantly boosts throughput allowing screening to keep pace with the overwhelming number of molecular targets being discovered. In this review, we analyse state-of-the-art droplet control technologies that exhibit potential to be used in this new generation of screening devices...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28627581/controlled-self-assembly-of-alginate-microgels-by-rapidly-binding-molecule-pairs
#6
Yuebi Hu, Angelo S Mao, Rajiv M Desai, Huanan Wang, David A Weitz, David J Mooney
Controlled self-assembly of cell-encapsulating microscale polymeric hydrogels (microgels) could be advantageous in a variety of tissue engineering and regenerative medicine applications. Here, a method of assembly by chemical modification of alginate polymer with binding pair molecules (BPM) was explored. Alginate was modified with several types of BPM, specifically biotin and streptavidin and click chemistry compounds, and fabricated into 25-30 μm microgels using a microfluidic platform. These microgels were demonstrated to self-assemble under physiological conditions...
June 19, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28627575/label-free-detection-of-aggregated-platelets-in-blood-by-machine-learning-aided-optofluidic-time-stretch-microscopy
#7
Yiyue Jiang, Cheng Lei, Atsushi Yasumoto, Hirofumi Kobayashi, Yuri Aisaka, Takuro Ito, Baoshan Guo, Nao Nitta, Natsumaro Kutsuna, Yasuyuki Ozeki, Atsuhiro Nakagawa, Yutaka Yatomi, Keisuke Goda
According to WHO, about 10 million new cases of thrombotic disorders are diagnosed worldwide every year. Thrombotic disorders, including atherothrombosis (the leading cause of death in the US and Europe), are induced by occlusion of blood vessels, due to the formation of blood clots in which aggregated platelets play an important role. The presence of aggregated platelets in blood may be related to atherothrombosis (especially acute myocardial infarction) and is, hence, useful as a potential biomarker for the disease...
June 19, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28620670/pesticide-vapor-sensing-using-an-aptamer-nanopore-and-agarose-gel-on-a-chip
#8
Satoshi Fujii, Aiko Nobukawa, Toshihisa Osaki, Yuya Morimoto, Koki Kamiya, Nobuo Misawa, Shoji Takeuchi
A pesticide vapor sensor was developed using an agarose gel-based chip containing a nanopore sensing system. Vaporized omethoate was detected by the absorption into the gel, the complex formation with a DNA aptamer, and its obstruction at the nanopore. This strategy is applicable to other vapors, expanding the versatility of nanopore sensors.
June 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28617509/controlled-rotation-and-translation-of-spherical-particles-or-living-cells-by-surface-acoustic-waves
#9
Ianis Bernard, Alexander A Doinikov, Philippe Marmottant, David Rabaud, Cédric Poulain, Pierre Thibault
We show experimental evidence of the acoustically-assisted micromanipulation of small objects like solid particles or blood cells, combining rotation and translation, using high frequency surface acoustic waves. This was obtained from the leakage in a microfluidic channel of two standing waves arranged perpendicularly in a LiNbO3 piezoelectric substrate working at 36.3 MHz. By controlling the phase lag between the emitters, we could, in addition to translation, generate a swirling motion of the emitting surface which, in turn, led to the rapid rotation of spherical polystyrene Janus beads suspended in the channel and of human red and white blood cells up to several rounds per second...
June 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28617487/organ-on-a-chip-devices-advance-to-market
#10
Boyang Zhang, Milica Radisic
To curb the high cost of drug development, there is an urgent need to develop more predictive tissue models using human cells to determine drug efficacy and safety in advance of clinical testing. Recent insights gained through fundamental biological studies have validated the importance of dynamic cell environments and cellular communication to the expression of high fidelity organ function. Building on this knowledge, emerging organ-on-a-chip technology is poised to fill the gaps in drug screening by offering predictive human tissue models with methods of sophisticated tissue assembly...
June 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28613308/on-chip-cryo-anesthesia-of-drosophila-larvae-for-high-resolution-in-vivo-imaging-applications
#11
Amrita Ray Chaudhury, Ryan Insolera, Ran-Der Hwang, Yih-Woei Fridell, Catherine Collins, Nikos Chronis
We present a microfluidic chip for immobilizing Drosophila melanogaster larvae for high resolution in vivo imaging. The chip creates a low-temperature micro-environment that anaesthetizes and immobilizes the larva in under 3 minutes. We characterized the temperature distribution within the chip and analyzed the resulting larval body movement using high resolution fluorescence imaging. Our results indicate that the proposed method minimizes submicron movements of internal organs and tissue without affecting the larva physiology...
June 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28613306/size-tunable-microvortex-capture-of-rare-cells
#12
Reem Khojah, Ryan Stoutamore, Dino Di Carlo
Inertial separation of particles and cells based on their size has advanced significantly over the last decade. However, size-based inertial separation methods require precise tuning of microfluidic device geometries to adjust the separation size of particles or cells. Here, we show a passive capture method that targets a wide size range of cells by controlling the flow conditions in a single device geometry. This multimodal capture device is designed to generate laminar vortices in lateral cavities that branch from long rectangular channels...
June 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28613302/all-soft-battery-free-and-wireless-chemical-sensing-platform-based-on-liquid-metal-for-liquid-and-gas-phase-voc-detection
#13
Min-Gu Kim, Hommood Alrowais, Choongsoon Kim, Pyungwoo Yeon, Maysam Ghovanloo, Oliver Brand
Lightweight, flexible, stretchable, and wireless sensing platforms have gained significant attention for personal healthcare and environmental monitoring applications. This paper introduces an all-soft (flexible and stretchable), battery-free, and wireless chemical microsystem using gallium-based liquid metal (eutectic gallium-indium alloy, EGaIn) and poly(dimethylsiloxane) (PDMS), fabricated using an advanced liquid metal thin-line patterning technique based on soft lithography. Considering its flexible, stretchable, and lightweight characteristics, the proposed sensing platform is well suited for wearable sensing applications either on the skin or on clothing...
June 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28613297/multi-dimensional-studies-of-synthetic-genetic-promoters-enabled-by-microfluidic-impact-printing
#14
Jinzhen Fan, Fernando Villarreal, Brent Weyers, Yunfeng Ding, Kuo Hao Tseng, Jiannan Li, Baoqing Li, Cheemeng Tan, Tingrui Pan
Natural genetic promoters are regulated by multiple cis and trans regulatory factors. For quantitative studies of these promoters, the concentration of only a single factor is typically varied to obtain the dose response or transfer function of the promoters with respect to the factor. Such design of experiments has limited our ability to understand quantitative, combinatorial interactions between multiple regulatory factors at promoters. This limitation is primarily due to the intractable number of experimental combinations that arise from multifactorial design of experiments...
June 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28613296/battery-operated-preconcentration-assisted-lateral-flow-assay
#15
Cheonjung Kim, Yong Kyoung Yoo, Sung Il Han, Junwoo Lee, Dohwan Lee, Kyungjae Lee, Kyo Seon Hwang, Kyu Hyoung Lee, Seok Chung, Jeong Hoon Lee
Paper-based analytical devices (e.g. lateral flow assays) are highly advantageous as portable diagnostic systems owing to their low costs and ease of use. Because of their low sensitivity and detection limits for biomolecules, these devices have several limitations in applications for real-field diagnosis. Here, we demonstrate a paper-based preconcentration enhanced lateral flow assay using a commercial β-hCG-based test. Utilizing a simple 9 V battery operation with a low power consumption of approximately 81 μW, we acquire a 25-fold preconcentration factor, demonstrating a clear sensitivity enhancement in the colorimetric lateral flow assay; consequently, clear colors are observed in a rapid kit test line, which cannot be monitored without preconcentration...
June 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28608907/organs-on-chips-with-combined-multi-electrode-array-and-transepithelial-electrical-resistance-measurement-capabilities
#16
Ben M Maoz, Anna Herland, Olivier Y F Henry, William D Leineweber, Moran Yadid, John Doyle, Robert Mannix, Ville J Kujala, Edward A FitzGerald, Kevin Kit Parker, Donald E Ingber
Here we demonstrate that microfluidic cell culture devices, known as Organs-on-a-Chips can be fabricated with multifunctional, real-time, sensing capabilities by integrating both multi-electrode arrays (MEAs) and electrodes for transepithelial electrical resistance (TEER) measurements into the chips during their fabrication. To prove proof-of-concept, simultaneous measurements of cellular electrical activity and tissue barrier function were carried out in a dual channel, endothelialized, heart-on-a-chip device containing human cardiomyocytes and a channel-separating porous membrane covered with a primary human endothelial cell monolayer...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28608904/droplet-based-light-sheet-fluorescence-microscopy-for-high-throughput-sample-preparation-3-d-imaging-and-quantitative-analysis-on-a-chip
#17
Hao Jiang, Tingting Zhu, Hao Zhang, Jun Nie, Zeyi Guan, Chi-Ming Ho, Sheng Liu, Peng Fei
We report a novel fusion of droplet microfluidics and light-sheet microscopy, to achieve high-throughput sample compartmentalization, manipulation and three-dimensional imaging on a chip. This optofluidic device characterized by orthogonal plane illumination and rapid liquid handling is compact and cost-effective, and capable of preparing sample droplets with tunable size, frequency and ingredient. Each droplet flowing through the device's imaging region is self-scanned by a laser-sheet, three-dimensionally reconstructed and quantitatively analysed...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28608886/effects-of-diffusion-and-mixing-pattern-on-microfluidic-assisted-synthesis-of-chitosan-atp-nanoparticles
#18
Amanda C S N Pessoa, Caroline C Sipoli, Lucimara G de la Torre
Chitosan (CHI) nanoparticles present promising applications in pharmaceutical and biomedical fields, including drug and gene delivery. Among different approaches, microfluidics emerges as a resourceful tool for nanoparticle production in low-cost, reproducible processes with predictable fluid dynamics. However, microfluidic-assisted synthesis of CHI nanoparticles has not been widely explored in the literature. In this context, we systematically investigated different process parameters that influence the synthesis of CHI/ATP nanoparticles...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28604891/pre-concentration-by-liquid-intake-by-paper-p-clip-a-new-technique-for-large-volumes-and-digital-microfluidics
#19
Darius G Rackus, Richard P S de Campos, Calvin Chan, Maria M Karcz, Brendon Seale, Tanya Narahari, Christopher Dixon, M Dean Chamberlain, Aaron R Wheeler
Microfluidic platforms are an attractive option for incorporating complex fluid handling into low-cost and rapid diagnostic tests. A persistent challenge for microfluidics, however, is the mismatch in the "world-to-chip" interface - it is challenging to detect analytes present at low concentrations in systems that can only handle small volumes of sample. Here we describe a new technique termed pre-concentration by liquid intake by paper (P-CLIP) that addresses this mismatch, allowing digital microfluidics to interface with volumes on the order of hundreds of microliters...
June 12, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28603798/comment-on-robust-scalable-high-throughput-production-of-monodisperse-drops-by-e-amstad-m-chemama-m-eggersdorfer-l-r-arriaga-m-p-brenner-and-d-a-weitz-lab-chip-2016-16-4163
#20
Mitsutoshi Nakajima
This comment on an article that appeared in Lab on a Chip (Amstad et al., Lab Chip, 2016, 16, 4163-4172) provides information on the performance of microchannel (step) emulsification devices developed by the Nakajima Group.
June 12, 2017: Lab on a Chip
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