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Integrative Cancer Therapies

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https://www.readbyqxmd.com/read/29218996/use-of-complementary-and-alternative-medicine-among-newly-diagnosed-breast-cancer-patients-in-malaysia-an-early-report-from-the-mybcc-study
#1
Aina Farhana Zulkipli, Tania Islam, Nur Aishah Mohd Taib, Maznah Dahlui, Nirmala Bhoo-Pathy, Nabilla Al-Sadat, Hazreen Abdul Majid, Samsinah Hussain
BACKGROUND: The use of complementary and alternative medicine (CAM) has increased and little is known on CAM use during the initial period. Therefore, the aim was to determine prevalence of CAM use among newly diagnosed breast cancer patients prior to seeking conventional treatment. METHODS: This is a cross-sectional study involved interviewing newly diagnosed breast cancer patients in the University Malaya Medical Centre (UMMC) using a structured questionnaire...
December 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29161917/baker-s-yeast-sensitizes-metastatic-breast-cancer-cells-to-paclitaxel-in-vitro
#2
Nariman K Badr El-Din, Ashraf Z Mahmoud, Tahia Ali Hassan, Mamdooh Ghoneum
Our earlier studies have demonstrated that phagocytosis of baker's yeast ( Saccharomyces cerevisiae) induces apoptosis in different cancer cell lines in vitro and in vivo. This study aimed to examine how baker's yeast sensitizes murine and human breast cancer cells (BCC) to paclitaxel in vitro. This sensitizing effect makes lower concentrations of chemotherapy more effective at killing cancer cells, thereby enhancing the capacity of treatment. Three BCC lines were used: the metastatic murine 4T1 line, the murine Ehrlich ascites carcinoma (EAC) line, and the human breast cancer MCF-7 line...
November 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29161912/developing-an-integrative-treatment-program-for-cancer-related-fatigue-using-stakeholder-engagement-a-qualitative-study
#3
Claudia Canella, Michael Mikolasek, Matthias Rostock, Jörg Beyer, Matthias Guckenberger, Josef Jenewein, Esther Linka, Claudia Six, Sarah Stoll, Roger Stupp, Claudia M Witt
BACKGROUND: Although cancer-related fatigue (CRF) has gained increased attention in the past decade, it remains difficult to treat. An integrative approach combining conventional and complementary medicine interventions seems highly promising. Treatment programs are more likely to be effective if the needs and interests of the people involved are well represented. This can be achieved through stakeholder engagement. OBJECTIVES: The aim of the study was to develop an integrative CRF treatment program using stakeholder engagement and to compare it to an expert version...
November 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29156992/evaluation-fucoidan-extracts-from-undaria-pinnatifida-and-fucus-vesiculosus-in-combination-with-anticancer-drugs-in-human-cancer-orthotopic-mouse-models
#4
Maryam Burney, Lata Mathew, Anjali Gaikwad, Elizabeth K Nugent, Anneliese O Gonzalez, Judith A Smith
OBJECTIVE: To determine the activity of fucoidan from Undaria pinnatifida (UPF) and Fucus vesiculosus (FVF) when given in combination of chemotherapy drugs using selected human breast or ovarian cancer orthotopic mouse models. METHODS: Mice were inoculated with 1 × 10(6) cells of TOV-112d, MCF-7, or ZR-75 subcutaneously or SKOV3-GFP-Luc intraperitoneally on day 0. MCF-7 and ZR-75 mice were administered with estradiol valerate 2 mg/kg in 0.2 mL castor oil subcutaneously two days prior to cell inoculation...
November 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29108428/the-effect-of-transarterial-chemoembolization-in-combination-with-kang-ai-injection-on-patients-with-intermediate-stage-hepatocellular-carcinoma-a-prospective-study
#5
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Mei Yang, Xi-Nan Wu
BACKGROUND: The outcome of patients with intermediate stage hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE) remains poor. Search for a more effective therapy is still necessary. OBJECTIVE: This study aimed to investigate the effect of combining TACE with Kang'ai (KA) injection for treating patients with intermediate stage HCC. METHODS: A total of 89 patients with intermediate stage HCC were enrolled and divided into TACE +KA group (n = 48) receiving repeated TACE plus KA injection, and TACE group (n = 41) receiving repeated TACE alone...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29094627/feasibility-of-homeopathic-treatment-for-symptom-reduction-in-an-integrative-oncology-service
#6
Noah Samuels, Yakov Freed, Rony Weitzen, Merav Ben-David, Yair Maimon, Uri Eliyahu, Raanan Berger
BACKGROUND: Homeopathy has the potential to reduce symptoms related to cancer treatment. The present study examined the feasibility of a homeopathic consultation and treatment program, provided as part of an integrative oncology service. METHODS: The electronic medical files of patients undergoing a homeopathic consultation in an integrative oncology service clinic were examined retrospectively. Adherence to the homeopathic treatment regimen and perceived response to the treatment were evaluated...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29094616/acupuncture-in-oncology-the-effectiveness-of-acupuncture-may-not-depend-on-needle-retention-duration
#7
Byeongsang Oh, Thomas Eade, Andrew Kneebone, George Hruby, Gillian Lamoury, Nick Pavlakis, Stephen Clarke, Chris Zaslawski, Isobel Marr, Daniel Costa, Michael Back
BACKGROUND: Guidelines surrounding optimum needle retention duration in acupuncture have not been established, despite a growing evidence base for acupuncture over recent decades. This retrospective study explored the effect of varying acupuncture needle retention durations in cancer patients. METHOD: Patients received either 2 (n = 35), 10 (n = 53), or 20 minutes (n = 54) of acupuncture once a week for 6 weeks. Outcomes of anxiety and depression, stress, fatigue, and quality of life (QOL), with the Hospital Anxiety and Depression Scale, Perceived Stress Scale, Functional Assessment of Cancer Therapy-Fatigue, and European Organization for Research and Treatment of Cancer Quality of Life, were measured at baseline and at 6 weeks following the intervention...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29094602/a-preclinical-evaluation-of-the-antitumor-activities-of-edible-and-medicinal-mushrooms-a-molecular-insight
#8
Thomson Patrick Joseph, Warren Chanda, Arshad Ahmed Padhiar, Samana Batool, Shao LiQun, MinTao Zhong, Min Huang
Cancer is the leading cause of morbidity and mortality around the globe. For certain types of cancer, chemotherapy drugs have been extensively used for treatment. However, severe side effects and the development of resistance are the drawbacks of these agents. Therefore, development of new agents with no or minimal side effects is of utmost importance. In this regard, natural compounds are well recognized as drugs in several human ailments, including cancer. One class of fungi, "mushrooms," contains numerous compounds that exhibit interesting biological activities, including antitumor activity...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29076388/effects-of-theory-based-behavioral-interventions-on-physical-activity-among-overweight-and-obese-female-cancer-survivors-a-systematic-review-of-randomized-controlled-trials
#9
Amerigo Rossi, Ciarán Friel, Leeja Carter, Carol Ewing Garber
PURPOSE: To determine whether theory-based physical activity (PA) interventions for overweight and obese female cancer survivors lead to increased PA and improved health. METHODS: This systematic review examined randomized controlled trials analyzing the impact of theory-based PA interventions on overweight and obese female cancer survivors through December 2016. Searches of 5 electronic databases revealed 10 articles that included 1351 participants who met the inclusion criteria...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29076387/the-efficacy-and-safety-of-transcutaneous-acupoint-interferential-current-stimulation-for-cancer-pain-patients-with-opioid-induced-constipation-a-prospective-randomized-controlled-study
#10
Hua-Dong Zhu, Zhen Gong, Bing-Wei Hu, Qiao-Ling Wei, Jun Kong, Cong-Bin Peng
INTRODUCTION: Opioid-induced constipation (OIC) is a principal complication secondary to analgesic therapy for cancer pain patients who suffer moderate to severe pain. In this study, we observe the efficacy and safety of transcutaneous acupoint interferential current (IFC) stimulation in those patients with OIC. METHODS: A total of 198 patients were randomly allocated to the IFC group and control group in a 1:1 ratio. Finally, 98 patients in the IFC group received 14 sessions administered over 2 weeks, whereas 100 patients in the control group took lactulose orally during the same period...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29037071/evidence-based-review-of-biobran-mgn-3-arabinoxylan-compound-as-a-complementary-therapy-for-conventional-cancer-treatment
#11
Soo Liang Ooi, Debbie McMullen, Terry Golombick, Dipl Nut, Sok Cheon Pak
INTRODUCTION: Conventional cancer treatment, including surgery, chemotherapy, and radiotherapy, may not be sufficient to eradicate all malignant cells and prevent recurrence. Intensive treatment often leads to a depressed immune system, drug resistance, and toxicity, hampering the treatment outcomes. BioBran/MGN-3 Arabinoxylan is a standardized arabinoxylan concentrate which has been proposed as a plant-based immunomodulator that can restore the tumor-induced disturbance of the natural immune system, including natural killer cell activity to fight cancer, complementing conventional therapies...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29034740/efficacy-and-safety-of-the-traditional-herbal-medicine-gamiguibi-tang-in-patients-with-cancer-related-sleep-disturbance-a-prospective-randomized-wait-list-controlled-pilot-study
#12
Jee Young Lee, Hye Kyung Oh, Han Sung Ryu, Sung Soo Yoon, Wankyu Eo, Seong Woo Yoon
BACKGROUND: Sleep disturbance is the second most bothersome symptom in patients with cancer, and it can significantly impair their quality of life. The aim of this study was to investigate the efficacy and safety of the traditional herbal medicine Gamiguibi-tang (GGBT) in patients with cancer-related sleep disturbance. METHODS: We conducted a prospective, randomized, wait-list-controlled, open-label pilot clinical trial on cancer-related sleep disturbance. Patients with cancer experiencing poor sleep quality with a Pittsburgh Sleep Quality Index of at least 6 were randomly assigned to the GGBT and wait-list groups to receive GGBT and conventional care, respectively, for 2 weeks...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29025275/complementary-and-alternative-medicine-use-in-minority-and-medically-underserved-oncology-patients-assessment-and-implications
#13
Desiree Jones, Lorenzo Cohen, Alyssa G Rieber, Diana Urbauer, Bryan Fellman, Michael J Fisch, Arlene Nazario
INTRODUCTION: Complementary and alternative medicine (CAM) use in minority and medically underserved oncology patients is not well documented. We assessed knowledge and utilization of CAM in a sample of these patients receiving treatment at an urban community hospital. METHODS: Patients with cancer were interviewed using an electronic application that depicted specific CAM therapies. Patients were questioned on their knowledge and utilization of therapies, deterrents to use, and interest in using these therapies if they were made available...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29096568/preclinical-evaluation-of-safety-of-fucoidan-extracts-from-undaria-pinnatifida-and-fucus-vesiculosus-for-use-in-cancer-treatment
#14
Lata Mathew, Maryam Burney, Anjali Gaikwad, Pranavand Nyshadham, Elizabeth K Nugent, Anneliese Gonzalez, Judith A Smith
OBJECTIVES: To evaluate potential hepatic metabolism-mediated drug interactions with fucoidan from Undaria pinnatifida (UPF) or Fucus vesiculosus (FVF) and potential growth inhibition activity with either fucoidan alone or with chemotherapy. In vivo studies were done to confirm safety and investigate fucoidan-mediated immune modulation. METHODS: Cytochrome P450 (CYP450) 3A4, 2C8, 2C9, and 2D6 inhibition experiments were conducted in vitro followed by an ex vivo human hepatocytes model to evaluate the CYP450 induction potential of each fucoidan at highest theoretical concentrations...
December 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27923905/%C3%AE-lapachone-inhibits-lung-metastasis-of-colorectal-cancer-by-inducing-apoptosis-of-ct26-cells
#15
Ji-Ye Kee, Yo-Han Han, Jinbong Park, Dae-Seung Kim, Jeong-Geon Mun, Kwang Seok Ahn, Hyun-Jung Kim, Jae-Young Um, Seung-Heon Hong
BACKGROUND: β-Lapachone is a quinone-containing compound found in red lapacho ( Tabebuia impetiginosa, syn. T avellanedae) trees. Lapacho has been used in traditional medicine by several South and Central American indigenous people to treat various types of cancer. The purpose of this study was to investigate the antimetastatic properties of β-lapachone and the underlying mechanisms using colon cancer cells. METHODS: This research used metastatic murine colon cancer cell lines, colon 26 (CT26) and colon 38 (MC38)...
December 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903841/influence-of-a-moderate-intensity-exercise-program-on-early-nk-cell-immune-recovery-in-pediatric-patients-after-reduced-intensity-hematopoietic-stem-cell-transplantation
#16
Carolina Chamorro-Viña, Jaime Valentín, Lucía Fernández, Marta González-Vicent, Margarita Pérez-Ruiz, Alejandro Lucía, S Nicole Culos-Reed, Miguel Ángel Díaz, Antonio Pérez-Martínez
INTRODUCTION: After allogeneic hematopoietic stem cell transplantation (HSCT), NK cell reconstitution, which is crucial for positive outcomes, is dominated by the CD56(bright) subset with low NK cell cytotoxicity (NKCC) activity. Moderate exercise has been described as a potent NK cell stimulus in adults with cancer. PURPOSE: To determine the effects of a moderate-intensity exercise program on NK cell recovery early after HSCT and the feasibility of this intervention...
December 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#17
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
December 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27899698/illuminating-a-risk-for-breast-cancer-a-preliminary-ecological-study-on-the-association-between-streetlight-and-breast-cancer
#18
Atalya Keshet-Sitton, Keren Or-Chen, Eran Huber, Abraham Haim
Artificial light at night (ALAN) for elongating photophase is a new source of pollution. We examined the association between measured ALAN levels and breast cancer (BC) standard morbidity ratio (SMR) at a statistical area (SA) level in an urban environment. Sample size consisted of 266 new BC cases ages 35-74. Light measurements (lux) were performed in 11 SAs. A new calculated variable of morbidity per SA size (SMR35-74/km(2)) was correlated with the light variables per road length, using Pearson correlations (P < ...
December 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27879377/promising-compounds-from-murraya-exotica-for-cancer-metastasis-chemoprevention
#19
Su-Dan He, Xing-Tian Yang, Cui-Cui Yan, Zhou Jiang, Su-Hong Yu, Yu-Yang Zhou, Lee Jia
Most of the present anticancer drugs are highly cytotoxic and focus mainly on killing tumor cells rather than slowing the progress of cancer metastasis. Evidence has been reported that bridges the mechanisms of inflammation and tumor invasion. Therefore, we evaluated the potency in cancer metastasis chemoprevention of compounds and a coumarin extracted from Murraya exotica, which is known for its anti-inflammation bioactivity. By carrying out experiments in vitro, we found the root extracts more efficient than the leaf extracts in restraining cell migration of MDA-MB-231 cells, while leaf extracts presented slightly stronger inhibition of tumor cell adhesion at low concentrations...
December 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27879375/the-role-of-oxidative-stress-in-koenimbine-induced-dna-damage-and-heat-shock-protein-modulation-in-hepg2-cells
#20
Yahya Hasan Hobani
BACKGROUND: Murraya koenigii (L.) Spreng, is a significant herb of traditional Ayurvedic system of medicine. Koenimbine, a carbazole alkaloid isolated from this plant holds antiproliferative and apoptotic effects. The aim of this study was to assess koenimbine-induced DNA damage and to clarify the role of free radicals in cell death mechanisms, using HepG2 cells. METHODS: The level of cytotoxicity was assayed by MTT assay. To elucidate the role of glutathione (GSH), the intracellular GSH level was analyzed...
December 2017: Integrative Cancer Therapies
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