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Integrative Cancer Therapies

Abdelnaser A Badawy, Mohammed A El-Magd, Sana A AlSadrah
BACKGROUND/OBJECTIVES: In the Middle East, people consume camel milk regularly as it is believed to improve immunity against diseases and decrease the risk for cancer. Recently, it was noted that most of the beneficial effects of milk come from their nanoparticles, especially exosomes. Herein, we evaluated the anticancer potential of camel milk and its exosomes on MCF7 breast cancer cells (in vitro and in vivo) and investigated the possible underlying molecular mechanism of action. METHODS/RESULTS: Administration of camel milk (orally) and its exosomes (orally and by local injection) decreased breast tumor progression as evident by ( a) higher apoptosis (indicated by higher DNA fragmentation, caspase-3 activity, Bax gene expression, and lower Bcl2 gene expression), ( b) remarkable inhibition of oxidative stress (decrease in MDA levels and iNOS gene expression); ( c) induction of antioxidant status (increased activities of SOD, CAT, and GPX), ( d) notable reduction in expression of inflammation-( IL1b, NFκB), angiogenesis-( VEGF) and metastasis-( MMP9, ICAM1) related genes; and ( e) higher immune response (high number of CD+ 4, CD+ 8, NK1...
July 1, 2018: Integrative Cancer Therapies
Ruochen Dong, Ping Chen, Qi Chen
Pancreatic cancers are enriched with cancer stem-like cells (CSCs), which are resistant to chemotherapies, and responsible for tumor metastasis and recurrence. Here, we investigated the extract of a medicinal plant Pao Pereira (Pao) for its activity against pancreatic CSCs. Pao inhibited overall proliferation of human pancreatic cancer cell lines with IC50 ranging from 125 to 325 μg/mL and had limited cytotoxicity to normal epithelial cells. Pancreatic CSC population, identified using surface markers CD24+ CD44+ EpCam+ or tumor spheroid formation assay, was significantly reduced, with IC50 s of ~100 μg/mL for 48 hours treatment, and ~27 μg/mL for long-term treatment...
July 1, 2018: Integrative Cancer Therapies
XiaoXiao Yu, Xue-Jun Lin, Shuang Wang, XiuHong Liu, WeiHua Li, Bu-Xin Kou, MengYin Chai, DeXi Chen, XiaoNi Liu, XiaoJun Wang
OBJECTIVE: Huqizhengxiao (HQZX) decoction is a mixture of traditional Chinese medicines comprising 10 herbs, with inhibitory effects on hepatocarcinoma. The aim of the study is to observe the antitumor efficacy and mechanism of HQZX decoction in nude mice with hepatocellular carcinoma xenografts. METHODS: HepG2-luc subcutaneous hepatocarcinoma was established in nude mice. The mice were divided into 5 groups: control, cinobufagin, HQZXS, HQZXM, and HQZXH with doses 13...
July 1, 2018: Integrative Cancer Therapies
Michael K Baker, Carolyn J Peddle-McIntyre, Daniel A Galvão, Catherine Hunt, Nigel Spry, Robert U Newton
INTRODUCTION: Women with breast cancer are often prescribed aromatase inhibitors, which can cause rapid loss of bone mass leading to significant potential for morbidity. Vibration training has been shown to be helpful in reducing bone turnover in postmenopausal women without cancer. AIM: To examine the effect of vibration stimulus on markers of bone turnover in breast cancer patients receiving aromatase inhibitors. METHODS: Thirty-one breast cancer survivors undergoing treatment with aromatase inhibitors were randomized to vibration stimulus (n = 14) or usual care control (n = 17)...
June 1, 2018: Integrative Cancer Therapies
Lauren A Zatarain, Derek K Smith, Jie Deng, Jill Gilbert, Mary S Dietrich, Kenneth J Niermann, Sheila H Ridner, Barbara A Murphy
OBJECTIVE: This study was designed to assess the feasibility of using the Jaw Dynasplint System as an adjunct to conventional stretching exercises as a preventative measure against trismus in patients undergoing radiotherapy. METHODS: Study participants (n = 40) were randomized using a permuted block design to conventional stretching or stretching plus use of the Jaw Dynasplint 3 times per day for 30 minutes. Patients were instructed to record maximum interincisal opening each day as well as logging use of the Jaw Dynasplint...
June 1, 2018: Integrative Cancer Therapies
Brett C Bade, J Madison Hyer, Benjamin T Bevill, Alex Pastis, Alana M Rojewski, Benjamin A Toll, Gerard A Silvestri
INTRODUCTION: Physical activity (PA) is a potential therapy to improve quality of life in patients with advanced-stage lung cancer (LC), but no PA regimen has been shown to be beneficial, clinically practical, and sustainable. We sought to test the hypothesis that a patient-centered activity regimen (PCAR) will improve patient participation and PA more effectively than weekly phone calls. METHODS: In patients with advanced-stage LC, we implemented a walking-based activity regimen and motivated patients via either weekly phone calls (n = 29; FitBit Zip accelerometer) or PCAR (n = 15; FitBit Flex, an educational session, and twice-daily gain-framed text messages)...
June 1, 2018: Integrative Cancer Therapies
Luis C Lopes-Júnior, Gabriela Pereira-da-Silva, Denise S C Silveira, Luciana C Veronez, Jéssica C Santos, Jonas B Alonso, Regina A G Lima
BACKGROUND: Pediatric cancer patients experience different psychological processes during hospitalization that may regulate the immune response and affect recovery and response to cancer treatment. In this study, we aimed to examine the feasibility of longitudinal testing of psychophysiological parameters of stress and fatigue in pediatric osteosarcoma patients hospitalized for chemotherapy submitted to clown intervention; and to investigate whether changes in the levels of biomarkers are associated with psychological stress and fatigue levels in these patients after the clown intervention...
June 1, 2018: Integrative Cancer Therapies
Jonas Sørensen
Cachexia has been recognized for a long time as an adverse effect of cancer. It is associated with reduced physical function, reduced tolerance to anticancer therapy, and reduced survival. This wasting syndrome is mainly known for an ongoing loss of skeletal muscle leading to progressive functional impairment and is driven by a variable combination of reduced food intake and abnormal metabolism. Cytokines derived from host immune system or the tumor itself is believed to play a role in promoting cancer cachexia...
June 1, 2018: Integrative Cancer Therapies
Jane Elizabeth Frawley, Erica McIntyre, David Sibbritt, Jon Wardle, Janet Schloss, Romy Lauche, Jon Adams
INTRODUCTION: Complementary medicine (CM) use has been found to influence the uptake of conventional cancer treatment. This study examines associations between CM use and cancer screening rates. METHODS: Women aged 62 to 67 years from the Australian Longitudinal Study on Women's Health were surveyed regarding their use of cancer screening initiatives. Associations between cancer screening behavior and visits to CM practitioners were analyzed. RESULTS: Of the 9151 women, 9049 (98...
June 1, 2018: Integrative Cancer Therapies
Lingyun Sun, Jun J Mao, Emily Vertosick, Christina Seluzicki, Yufei Yang
BACKGROUND: Traditional Chinese medicine (TCM) is widely used among Chinese cancer patients. However, little is known about Chinese patients' expectations and barriers toward using TCM for cancer. METHODS: We conducted a cross-sectional survey within a patient-support group, the Beijing Anti-Cancer Association. We measured the outcome, Chinese cancer survivors' expectations and barriers toward TCM utilization, using a modified version of ABCAM (Attitudes and Beliefs towards Complementary and Alternative Medicine), the ABTCM (Attitudes and Beliefs towards Traditional Chinese Medicine)...
June 1, 2018: Integrative Cancer Therapies
Favil Singh, Daniel A Galvão, Robert U Newton, Nigel A Spry, Michael K Baker, Dennis R Taaffe
BACKGROUND: Neoadjuvant chemoradiation treatment (CRT) in rectal cancer patients is associated with a reduction in physical capacity, lean mass and increased fatigue. As a countermeasure to these treatment-related adverse effects, we examined the feasibility and preliminary efficacy of a 10-week exercise program during CRT. METHODS: Ten rectal cancer patients (7 men, aged 27-70 years, body mass index = 26.4 ± 3.8 kg/m2 ) receiving CRT undertook supervised resistance and aerobic exercise twice weekly...
June 1, 2018: Integrative Cancer Therapies
Carolin C Hack, Janina Hackl, Nina B M Hüttner, Hanna Langemann, Judith Schwitulla, Svenja Dietzel-Drentwett, Peter A Fasching, Matthias W Beckmann, Anna-Katharin Theuser
PURPOSE: Although the demand from patients for integrative medicine is increasing, complementary medicine services are still quite heterogeneous and have not been incorporated into clinical routine. The aim of this study was to systematically evaluate improvements in side effects and quality of life associated with a hospital-based integrative medicine program in the modern breast cancer patient care setting. METHODS: In a cross-sectional study, integrative health counseling and treatment were evaluated in women with breast cancer...
May 1, 2018: Integrative Cancer Therapies
Cheng Zhang, Ning Wang, Hor-Yue Tan, Wei Guo, Sha Li, Yibin Feng
Bearing in mind the doctrine of tumor angiogenesis hypothesized by Folkman several decades ago, the fundamental strategy for alleviating numerous cancer indications may be the strengthening application of notable antiangiogenic therapies to inhibit metastasis-related tumor growth. Under physiological conditions, vascular sprouting is a relatively infrequent event unless when specifically stimulated by pathogenic factors that contribute to the accumulation of angiogenic activators such as the vascular endothelial growth factor (VEGF) family and basic fibroblast growth factor (bFGF)...
May 1, 2018: Integrative Cancer Therapies
Yingchun Zeng, Andy S K Cheng, Ting Song, Xiujie Sheng, Shaojing Wang, Jianfei Xie, Chetwyn C H Chan
BACKGROUND: Among women in China, gynecological cancers are the second most common cancers after breast cancer. Cancer-related cognitive impairment (CRCI) has emerged as a significant problem affecting gynecological cancer survivors. While acupuncture has been used in different aspects of cancer care, the possible positive effects of acupuncture on cognitive impairment have received little attention. This study hypothesized that patients would demonstrate lower neurocognitive performance and lower structural connectivity compared to healthy controls...
May 1, 2018: Integrative Cancer Therapies
Alana Gall, Stuart Leske, Jon Adams, Veronica Matthews, Kate Anderson, Sheleigh Lawler, Gail Garvey
BACKGROUND: Cancer 'patients' are increasingly using traditional indigenous and complementary medicines (T&CM) alongside conventional medical treatments to both cure and cope with their cancer diagnoses. To date T&CM use among Indigenous cancer patients from Australia, Canada, New Zealand, and the United States has not been systematically reviewed. METHODS: We systematically searched bibliographic databases to identify original research published between January 2000 and October 2017 regarding T&CM use by Indigenous cancer patients in Australia, Canada, New Zealand, and the United States...
May 1, 2018: Integrative Cancer Therapies
Lingling Sun, Paul Fahey, Xiaoshu Zhu, Weng Ng, Zhuo Ping Chen, Yiwen Qiu, Hezheng Lai, Jietao Lin, Lizhu Lin
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the major malignancies associated with high mortality rates. Chinese herbal medicine (CHM) alone, or in combination with conventional therapies (CT), has been widely used for patients with HCC in China. This study aims to explore how integrative therapy (IT) through the combination of CHM and CT affects the survival of patients with intermediate-advanced HCC. METHODS: A retrospective cohort study was performed at the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China...
May 1, 2018: Integrative Cancer Therapies
Anthony J Bazzan, George Zabrecky, Nancy Wintering, Andrew B Newberg, Daniel A Monti
BACKGROUND: Intravenous ascorbic acid (IV AA) has been used extensively in cancer patients throughout the United States. Currently, there are limited data on the safety and clinical effects of IV AA. The purpose of this study was to expand the current literature using a retrospective analysis of adverse events and symptomatic changes of IV AA in a large sample of cancer patients. METHODS: We conducted a retrospective chart review of all patients receiving IV AA for cancer at the Thomas Jefferson University Hospital over a 7-year period...
May 1, 2018: Integrative Cancer Therapies
Yuhang Zhao, Min Wang, Jokyab Tsering, Hanluo Li, Simin Li, Yuepeng Li, Yinghua Liu, Xianda Hu
OBJECTIVES: Triphala is a herbal medicine that has been widely used for treating a variety of ailments. This study aims to systematically analyze the antitumor effects of Triphala on gynecological cancers. METHODS: The antineoplastic activities of Triphala on gynecological cancers were analyzed using network pharmacology-based strategies. Afterward, the human ovarian cancer cell line SK-OV-3, cervical cancer cell line HeLa, and endometrial cancer cell line HEC-1-B were selected for experimetal valification...
May 1, 2018: Integrative Cancer Therapies
Chris P Repka, Reid Hayward
BACKGROUND: Although the underlying mechanisms of cancer-related fatigue (CRF) are not fully characterized, treatment-associated oxidative stress may play a role. The purpose of this study was to determine the effect of an exercise intervention on the relationship between CRF and oxidative stress. METHODS: Upon cessation of radiation or chemotherapy, 8 cancer patients participated in a 10-week exercise intervention (EX), while 7 continued standard care (CON). Blood draws and fatigue questionnaires were administered to cancer patients before and after the intervention as well as to 7 age-matched individuals with no cancer history...
June 2018: Integrative Cancer Therapies
Rhys I Beaudry, Yuanyuan Liang, Steven T Boyton, Wesley J Tucker, R Matthew Brothers, Kathryn M Daniel, Roshni Rao, Mark J Haykowsky
Cancer and cardiovascular disease (CVD) are leading causes of morbidity and mortality in the United States. Vascular endothelial dysfunction, an important contributor in the development of CVD, improves with exercise training in patients with CVD. However, the role of regular exercise to improve vascular function in cancer survivors remains equivocal. We performed a meta-analysis to determine the effect of exercise training on vascular endothelial function in cancer survivors. We searched PubMed (1975 to 2016), EMBASE CINAHL (1937 to 2016), OVID MEDLINE (1948 to 2016), and Cochrane Central Registry of Controlled Trials (1991 to 2016) using search terms: vascular function, endothelial function, flow-mediated dilation [FMD], reactive hyperemia, exercise, and cancer...
June 2018: Integrative Cancer Therapies
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