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Integrative Cancer Therapies

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https://www.readbyqxmd.com/read/28438054/evaluation-of-active-hexose-correlated-compound-ahcc-in-combination-with-anticancer-hormones-in-orthotopic-breast-cancer-models
#1
Lata Mathew, Anjali Gaikwad, Anneliese Gonzalez, Elizabeth K Nugent, Judith A Smith
OBJECTIVE: To determine the impact on antitumor activity when active hexose correlated compound (AHCC) in combination with anticancer hormonal agents in orthotopic mouse models of human estrogen receptor positive breast cancer and evaluate impact of AHCC on aromatase activity. METHODS: The study consisted of 7 treatment arms (n=10) conducted in 2 breast cancer mouse models: MCF-7 and ZR-75. Treatment groups included untreated, vehicle, AHCC 50 mg/kg, AHCC 50 mg/kg + tamoxifen 10 mg/kg, tamoxifen 10 mg/kg, AHCC 50 mg/kg + letrozole 10 µg/mouse, or letrozole 10 µg/mouse...
April 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28438053/scorpion-venom-causes-upregulation-of-p53-and-downregulation-of-bcl-xl-and-bid-protein-expression-by-modulating-signaling-proteins-erk-1-2-and-stat3-and-dna-damage-in-breast-and-colorectal-cancer-cell-lines
#2
Abdulrahman Khazim Al-Asmari, Anvarbatcha Riyasdeen, Mozaffarul Islam
Scorpion venoms efficiently block the normal neurotransmitter signaling pathway by prejudicing the ion channel operating mechanism in the body system. Besides its negative effect, venoms also possess some beneficial qualities for humans. They have also been shown to exhibit anticancer properties in various cancer types. This unique property of the venom as an anticancer agent is mainly a result of its role in initiating apoptosis and inhibiting several signaling cascade mechanisms that promote cancer cell proliferation and growth...
April 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28381120/simultaneous-assessment-of-the-efficacy-and-toxicity-of-marine-mollusc-derived-brominated-indoles-in-an-in-vivo-model-for-early-stage-colon-cancer
#3
Babak Esmaeelian, Kirsten Benkendorff, Richard K Le Leu, Catherine A Abbott
The acute apoptotic response to genotoxic carcinogens animal model has been extensively used to assess the ability of drugs and natural products like dietary components to promote apoptosis in the colon and protect against colorectal cancer (CRC). This work aimed to use this model to identify the main chemopreventative agent in extracts from an Australian mollusc Dicathais orbita, while simultaneously providing information on their potential in vivo toxicity. After 2 weeks of daily oral gavage with bioactive extracts and purified brominated indoles, mice were injected with the chemical carcinogen azoxymethane (AOM; 10 mg/kg) and then killed 6 hours later...
April 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27185319/supercritical-fluid-extraction-of-citrus-iyo-hort-ex-tanaka-pericarp-inhibits-growth-and-induces-apoptosis-through-abrogation-of-stat3-regulated-gene-products-in-human-prostate-cancer-xenograft-mouse-model
#4
Chulwon Kim, Il Ho Lee, Ho Bong Hyun, Jong-Chan Kim, Rajendra Gyawali, Seok-Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Somi K Cho, Kwang Seok Ahn
Activation of signal transducer and activator of transcription 3 (STAT3) is well known to play a major role in the cell growth, survival, proliferation, metastasis, and angiogenesis of various cancer cells. Most of the citrus species offer large quantities of phytochemicals that have beneficial effects attributed to their chemical components. Our study was carried out to evaluate the anticancer effects of the pericarp of Iyokan ( Citrus iyo Hort. ex Tanaka), locally known as yeagam in Korea, through modulation of the STAT3 signaling pathway in both tumor cells and a nude mice model...
June 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27160279/onbaekwon-suppresses-colon-cancer-cell-invasion-by-inhibiting-expression-of-the-cxc-chemokine-receptor-4
#5
Buyun Kim, Jaewoo Yoon, Seong Woo Yoon, Byoungduck Park
Cysteine X cysteine (CXC) chemokine receptor 4 (CXCR4) and C-X-C motif chemokine 12 (CXCL12) were originally identified as chemoattractants between immune cells and sites of inflammation. Since studies have validated an increased level of CXCL12 and its receptor in patients with colorectal cancers, CXCL12/CXCR4 axis has been considered as a valuable marker of cancer metastasis. Therefore, identification of CXCR4 inhibitors has great potential to abrogate tumor metastasis. Onbaekwon (OBW) is a complex herbal formula that is derived from the literature of traditional Korean medicine Dongeuibogam...
June 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27154183/coping-profiles-differentiate-psychological-adjustment-in-chinese-women-newly-diagnosed-with-breast-cancer
#6
Lingyan Li, Shichen Li, Yuping Wang, Jinyao Yi, Yanjie Yang, Jincai He, Xiongzhao Zhu
OBJECTIVE: The study aimed to explore latent profiles of coping in Chinese women newly diagnosed with breast cancer and examine the differences of psychological distress, demographic, and medical characteristics across profiles. METHODS: Latent profile analysis was used to identify 3 classes of copers based on data from 618 Chinese women newly diagnosed with breast cancer who completed questionnaires assessing their coping strategies and psychological distress. RESULTS: "Adaptive coper," reporting most use of adaptive cognitive coping strategies, behaviors of acceptance and shifting attention, and least use of maladaptive cognitive coping strategies, had the best psychological adjustment...
June 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27151584/in-vitro-and-in-vivo-efficacy-studies-of-lavender-angustifolia-essential-oil-and-its-active-constituents-on-the-proliferation-of-human-prostate-cancer
#7
Yunqi Zhao, Ran Chen, Yun Wang, Chen Qing, Wei Wang, Yixin Yang
Lavandula angustifolia is the most widely cultivated Lavandula species. The extraction of its flower and leaves has been used as herbal medicine. In this study, the in vitro antitumor activities were tested on human prostate cancer PC-3 and DU145 cell lines. Flow cytometry technology was applied to study apoptosis induction and cell cycle arrest. The PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice. Paraffin sections from xenograft tumor specimens were used in the TUNEL (terminal deocynucleotide transferase dUTP nick end labeling) assay and an immunohistochemistry assay to detect cell proliferation markers Ki67 and PCNA...
June 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27151581/probiotic-survey-in-cancer-patients-treated-in-the-outpatient-department-in-a-comprehensive-cancer-center
#8
Sona Ciernikova, Michal Mego, Maria Semanova, Lenka Wachsmannova, Zuzana Adamcikova, Viola Stevurkova, Lubos Drgona, Vladimir Zajac
PURPOSE: Availability without prescription restriction, low cost, and simple oral administration allow cancer patients to use probiotics without knowledge of potential risks. We present a survey of probiotic use and the association with patient tumor characteristics in cancer patients treated at the outpatient department of the National Cancer Institute in Slovakia. PATIENTS AND METHODS: Between March and December 2014, 499 patients were asked to evaluate their overall experience with probiotics by questionnaire form, including the length and method of use relative to anticancer therapy, expectations, side-effect experiences, understanding of the possible risks, dietary supplement use, and others...
June 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27151580/synergistic-apoptotic-effect-of-d-fraction-from-grifola-frondosa-and-vitamin-c-on-hepatocellular-carcinoma-smmc-7721-cells
#9
Fei Zhao, Yong-Feng Wang, Lei Song, Jia-Xin Jin, Ya-Qing Zhang, Hong-Yun Gan, Ke-Hu Yang
The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom. Anticancer activity was demonstrated using various concentrations of DFP alone or in combination with VC against the human hepatocarcinoma SMMC-7721 cell line. To investigate the anticancer mechanism, studies designed to detect cell apoptosis were conducted. Results from the MTT assay indicated that a combination of DFP (0...
June 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28150504/acupuncture-and-reflexology-for-chemotherapy-induced-peripheral-neuropathy-in-breast-cancer
#10
Idan Ben-Horin, Peretz Kahan, Larisa Ryvo, Moshe Inbar, Shahar Lev-Ari, Ravit Geva
BACKGROUND: Treatment of chemotherapy-induced peripheral neuropathy (CIPN), which affects approximately 30% to 40% of patients treated with neuropathy-causing agents, is mainly symptomatic. Currently available interventions are of little benefit. STUDY DESIGN: This study was conducted as a retrospective analysis of the efficacy of acupuncture and reflexology in alleviating CIPN in breast cancer patients. METHODS: Medical records of 30 consecutive breast cancer patients who received both chemotherapy and treatment for CIPN according to our Acupuncture and Reflexology Treatment for Neuropathy (ART-N) protocol between 2011 and 2012 were reviewed...
February 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28150503/yoga-program-for-high-grade-glioma-patients-undergoing-radiotherapy-and-their-family-caregivers
#11
Kathrin Milbury, Smitha Mallaiah, Anita Mahajan, Terri Armstrong, Shioa-Pei Weathers, Kathryn E Moss, Nazli Goktepe, Amy Spelman, Lorenzo Cohen
BACKGROUND: Despite their high symptom burden and poor prognosis, evidence-based supportive care interventions for adults with high-grade glioma (HGG) and their caregivers are lacking. Thus, we aimed to establish feasibility of a patient-caregiver dyadic yoga program (DYP) for newly diagnosed HGG patients and their family caregivers targeting quality-of-life (QOL) outcomes. METHOD: In this single-arm pilot trial, dyads participated in a 12-session DYP program across the course of patients' radiotherapy...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28110564/recruitment-to-the-breast-activity-and-healthy-eating-after-diagnosis-b-ahead-randomized-controlled-trial
#12
Mary Pegington, Judith E Adams, Nigel J Bundred, Anna M Campbell, Anthony Howell, Sacha J Howell, Shaun Speed, Jane Wolstenholme, Michelle N Harvie
Excess weight at breast cancer diagnosis and weight gain during treatment are linked to increased breast cancer specific and all-cause mortality. The Breast-Activity and Healthy Eating After Diagnosis (B-AHEAD) trial tested 2 weight loss diet and exercise programmes versus a control receiving standard written advice during adjuvant treatment. This article identifies differences in characteristics between patients recruited from the main trial site to those of the whole population from that site during the recruitment period and identifies barriers to recruitment...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28110563/the-hexane-fraction-of-bursera-microphylla-a-gray-induces-p21-mediated-antiproliferative-and-proapoptotic-effects-in-human-cancer-derived-cell-lines
#13
Sabrina Adorisio, Alessandra Fierabracci, Giulia Gigliarelli, Isabella Muscari, Lorenza Cannarile, Anna Marina Liberati, Maria Carla Marcotullio, Carlo Riccardi, Massimo Curini, Ramon Enrique Robles Zepeda, Domenico V Delfino
Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran desert in Mexico. The Seri ethnic group in the Sonoran desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28102098/a-randomized-double-blind-placebo-controlled-trial-of-fruit-and-vegetable-concentrates-on-intermediate-biomarkers-in-head-and-neck-cancer
#14
Mridul Datta, Edward G Shaw, Glenn J Lesser, L Douglas Case, Mara Z Vitolins, Charles Schneider, Bart Frizzell, Christopher Sullivan, Mark Lively, Elizabeth Franzmann, Jennifer J Hu
BACKGROUND: Head and neck cancer (HNC) patients are at an increased risk for developing second primary tumors (SPTs). Diets rich in fruits and vegetables (FVs) may lower HNC risk. FV concentrates may offer a potential alternative to increasing FV intake. METHODS: We conducted a randomized, double-blind, placebo-controlled trial to evaluate whether Juice PLUS+ (JP; a commercial product with multiple FV concentrates) has an effect on p27 and Ki-67, biomarkers associated with the risk of SPTs...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28056563/a-survey-of-licensed-acupuncturists-in-the-san-francisco-bay-area
#15
Donald Abrams, Michael McCulloch, Misha Cohen, Mike Liaw, Deborah Silverman, Carla Wilson
BACKGROUND: Many cancer patients seek traditional Chinese medicine (TCM), the prevalence varying with diagnosis, comorbidities, and demographics. Interventions sought include acupuncture, massage, herbs, diet, and exercise, usually combined with conventional therapies. It is not known what proportion of TCM practitioners care for cancer patients, their cancer specific training or caseload, what interventions they employ, their outcomes, and their communication patterns with conventional oncologists...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27923905/%C3%AE-lapachone-inhibits-lung-metastasis-of-colorectal-cancer-by-inducing-apoptosis-of-ct26-cells
#16
Ji-Ye Kee, Yo-Han Han, Jinbong Park, Dae-Seung Kim, Jeong-Geon Mun, Kwang Seok Ahn, Hyun-Jung Kim, Jae-Young Um, Seung-Heon Hong
BACKGROUND: β-Lapachone is a quinone-containing compound found in red lapacho (Tabebuia impetiginosa, syn. T avellanedae) trees. Lapacho has been used in traditional medicine by several South and Central American indigenous people to treat various types of cancer. The purpose of this study was to investigate the antimetastatic properties of β-lapachone and the underlying mechanisms using colon cancer cells. METHODS: This research used metastatic murine colon cancer cell lines, colon 26 (CT26) and colon 38 (MC38)...
December 5, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27923904/augmentation-of-cytolytic-activity-in-murine-natural-killer-cells-and-inhibition-of-tumor-growth-by-the-ethanol-fraction-of-oyster-extract
#17
Kaito Sakaguchi, Ming Zhong, Saeko Kawai, Yoshio Shimizu, Eiichi Gohda
A reduced number and/or reduced activity of natural killer (NK) cells, which are important for defense against a variety of cancers and viral infections, occur under various stress conditions and in patients with various diseases. In this article, we report that the 30% to 50% ethanol precipitate of oyster extract (EPOE50) dose-dependently enhanced the activity of mouse spleen NK cells in vitro and in vivo. The activity of EPOE50 was eluted with a molecular weight of about 2000 by gel filtration and was inactivated by periodate but not by proteinase K...
December 5, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28345362/mindfulness-based-movement
#18
Alexander R Lucas, Heidi D Klepin, Stephen W Porges, W Jack Rejeski
Compelling evidence suggests that physical activity is an effective intervention for cancer survivors, including for those undergoing active cancer treatments. However, to date most evidence has emerged from interventions that have promoted moderate to vigorous physical activity. In this conceptual review, we argue that attention should be given to the entire continuum of physical activity from reducing sedentary behavior to increasing higher levels of physical activity when possible. In addition, considerable evidence in the cancer literature supports the value of mindfulness-based interventions as a means of helping patients and survivors cope with the variety of threats that accompany this disease...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28088871/herbal-medicine-practices-of-patients-with-liver-cancer-in-peru
#19
Teresa Rojas Rojas, Geneviève Bourdy, Eloy Ruiz, Juan-Pablo Cerapio, Pascal Pineau, Jacques Gardon, Franco Doimi, Xavier Deparis, Eric Deharo, Stéphane Bertani
RATIONALE: The highest burden of liver cancer occurs in developing countries, where the use of herbal medicine (HM) is still widespread. Despite this trend, few studies have been conducted to report HM practices of patients with a hepatic tumor in the developing world. Hence, this study aimed to document the use of HM among patients with liver cancer in Peru. STUDY DESIGN AND METHODS: A comparative behavioral epidemiological survey was conducted among liver cancer patients attending the National Cancer Institute of Peru...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28050925/bone-mineral-density-balance-performance-balance-self-efficacy-and-falls-in-breast-cancer-survivors-with-and-without-qigong-training
#20
Shirley S M Fong, Anna W M Choi, W S Luk, Timothy T T Yam, Joyce C Y Leung, Joanne W Y Chung
PURPOSE: A deterioration in bone strength and balance performance after breast cancer treatment can result in injurious falls. Therefore, interventions need to be developed to improve the bone strength and balance ability of breast cancer survivors. This cross-sectional exploratory study aimed to compare the bone mineral density (BMD), balance performance, balance self-efficacy, and number of falls between breast cancer survivors who practiced qigong, breast cancer survivors who did not practice qigong, and healthy individuals...
December 1, 2016: Integrative Cancer Therapies
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