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Integrative Cancer Therapies

Waqas Iqbal, Saleh Alkarim, Tahseen Kamal, Hani Choudhry, Jamal Sabir, Roop S Bora, Kulvinder S Saini
BACKGROUND: The role of alkaloids isolated from Rhazya stricta Decne (Apocynaceae family) (RS) in targeting genes involved in cancer and metastasis remains to be elucidated. OBJECTIVE: Identify and characterize new compounds from RS, which inhibit gene(s) involved in the survival, invasion, self-renewal, and metastatic processes of cancer cells. METHODS: Bioinformatics study was performed using HISAT2, stringtie, and ballgown pipeline to understand expressional differences between a normal epithelial cell line-MCF10A and MCF7...
October 29, 2018: Integrative Cancer Therapies
Ralph Muecke, Knut Waldschock, Lutz Schomburg, Oliver Micke, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz, Jutta Huebner
INTRODUCTION: The supply of selenium (Se) varies widely in Germany. Therefore, a laboratory study was conducted in patients treated at a family doctor practice in Brandenburg, Germany, to determine whether there is a general Se deficiency in this area; specifically, whether Se concentrations differ with age, sex, or presence of cancer. Moreover, we tested the effects of a Se supplementation on whole blood Se levels (WBSL). METHODS: In 2006, WBSL were analyzed in 871 patients (496 females, 375 males, median age: 67 years)...
October 25, 2018: Integrative Cancer Therapies
Yi-Hua Lee, Gi-Ming Lai, De-Chih Lee, Lee-Jang Tsai Lai, Yuan-Ping Chang
OBJECTIVES: Cancer-related fatigue and fear of recurrence (FOR) are the most common symptoms in cancer survivors and severely affect quality of life (QOL). This study aims to promote and evaluate the effectiveness of physical and psychological rehabilitation activities for cancer survivors. METHODS: A longitudinal study with an interventional research design was conducted. A total of 80 participants were randomly assigned to experimental groups E1 (Qigong exercise [QE]) or E2 (stress management [SM]) or the control group...
October 25, 2018: Integrative Cancer Therapies
Jun Ni, Jian Feng, Linda Denehy, Yi Wu, Liqin Xu, Catherine L Granger
PURPOSE: This study aimed to measure symptoms of posttraumatic stress disorder (PTSD) in Chinese patients following a new diagnosis of lung cancer. Secondary aims were to explore factors at diagnosis that may predict PTSD symptoms at 6 months. METHODS: This was a prospective longitudinal observational study that included 93 patients with newly diagnosed lung cancer. PTSD symptomology was assessed using the PTSD Checklist Civilian Version (PCL-C) and health-related quality of life (HRQoL) was assessed with the European Organisation for the Research and Treatment of Cancer questionnaire...
October 25, 2018: Integrative Cancer Therapies
Jiro Nakano, Kaori Hashizume, Takuya Fukushima, Kazumi Ueno, Emi Matsuura, Yuta Ikio, Shun Ishii, Satoru Morishita, Koji Tanaka, Yoko Kusuba
OBJECTIVE: This study aimed to conduct a meta-analysis to establish the effect of exercise interventions on physical symptoms, including fatigue, nausea/vomiting, pain, dyspnea, insomnia, loss of appetite, constipation, and diarrhea in cancer patients and survivors. METHODS: We searched articles published before April 2017 using the following databases: Cochrane Library, PubMed/MEDLINE, CINAHL, Scopus, PEDro, Health & Medical Collection, and Psychology Database...
October 23, 2018: Integrative Cancer Therapies
Markus Horneber, Gerd van Ackeren, Felix Fischer, Herbert Kappauf, Josef Birkmann
PURPOSE: To report on a telephone consultation service with cancer patients and their relatives about complementary and alternative medicine (CAM) between 1999 and 2011. METHODS: We offered a Germany-wide, free-of-charge telephone consultation service about CAM led by oncology clinicians from a comprehensive cancer center. The consultations followed a patient-centered approach with the aim to provide guidance and evidence-based information. Sociodemographic, disease-related data as well as information about the consultations' content were collected in a standardized manner, and feedback questionnaires were sent out immediately after the consultations...
October 23, 2018: Integrative Cancer Therapies
Jennifer Huberty, Ryan Eckert, Linda Larkey, Krisstina Gowin, Jules Mitchell, Ruben Mesa
Myeloproliferative neoplasms (MPNs) are rare hematological malignancies with a significant symptom burden often left unresolved despite recent advances in pharmacological therapy. Yoga is a nonpharmacological strategy that has been shown to improve symptoms in other cancers and may be effective for improving symptoms in MPN patients. Online yoga helps address many of the commonly reported barriers of cancer patients to in-person interventions and may make yoga more accessible to MPNs. An exploration of MPN patient perceptions of participation in online yoga is needed to tailor interventions to patient needs and inform future studies...
October 23, 2018: Integrative Cancer Therapies
Huiping Ding, Shengjin Dou, Yiqun Ling, Guopei Zhu, Qiong Wang, Yan Wu, Yong Qian
AIM: This was a prospective investigation of longitudinal body composition changes in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy (CCRT) and a comparison of the Patient-Generated Subjective Global Assessment (PG-SGA) and the ESPEN (European Society for Clinical Nutrition and Metabolism) diagnostic criteria (EDC) as evaluation methods. METHODS: All patients received standard CCRT according to 2 centers' current practices. Body composition parameters were determined by bioelectrical impedance analysis and obtained weekly from baseline until the end of treatment...
October 20, 2018: Integrative Cancer Therapies
Ge Guo, Juhua Zhou, Xiaogaung Yang, Jiang Feng, Yanxia Shao, Tingting Jia, Qingrong Huang, Yanmin Li, Yin Zhong, Prakash S Nagarkatti, Mitzi Nagarkatti
MicroRNAs (miRNAs) are highly conserved, noncoding small RNAs that regulate gene expression, and consequently several important functions including early embryo development, cell cycle, programmed cell death, cell differentiation, and metabolism. While there are no effective treatments available against hepatocellular carcinoma (HCC), some Chinese herbal medicines have been shown to regulate growth, differentiation, invasion, and metastasis of HCC. Many studies have shown that Chinese herbal medicines regulate the expression of miRNAs and this may be associated with their ability to control the development of HCC...
October 20, 2018: Integrative Cancer Therapies
Yair Maimon, Noah Samuels, Zoya Cohen, Raanan Berger, David S Rosenthal
BACKGROUND AND PURPOSE: LCS101 is a botanical formula extracted from 14 botanical components. While conventional oncology focuses on targeted medicine, research on LCS101 adopts a multi-targeted approach, examining its preclinical (in vitro, in vivo, and ex vivo) and clinical (randomized controlled trial, pragmatic) effects. This includes examining the formula's impact on the immune system, selective anticancer effects, and improved chemotherapy-related symptoms and quality of life. Effects on the Immune System: In murine splenic cell cultures, LCS101 significantly increased T-cell proliferation and macrophage tumor necrosis factor-α production...
October 10, 2018: Integrative Cancer Therapies
Jae-Woo Park, Jayoung Oh, Seok-Jae Ko, Mun Seog Chang, Jinsung Kim
In most cancer patients, chemotherapy-induced oral mucositis (OM) is a frequent side effect, leading to low quality of life and delay in therapy. The aim of this study was to evaluate the effects of Onchung-eum, a well-known herbal prescription in traditional medicine comprising 8 herbs that has long been used for skin diseases, on 5-fluorouracil (5-FU)-induced OM in human pharyngeal cells and golden Syrian hamsters. DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, and reactive oxygen species production were measured in vitro...
October 8, 2018: Integrative Cancer Therapies
Marta Maschio, Alessia Zarabla, Andrea Maialetti, Francesco Marchesi, Diana Giannarelli, Svitlana Gumenyuk, Francesco Pisani, Daniela Renzi, Edvina Galiè, Andrea Mengarelli
BACKGROUND AND AIMS: Peripheral neuropathy is a common complication of chemotherapy that can induce marked disability that negatively affects the quality of life in patients with multiple myeloma (MM). The aim of this study was to prevent the onset or the worsening of peripheral neuropathy in MM patients treated with bortezomib (BTZ), using a new nutritional neuroprotective compound. We report preliminary results of 18 out of 33 patients who completed the study. METHODS: We administered a tablet of Neuronorm to patients, containing docosahexaenoic acid 400 mg, α-lipoic acid 600 mg, vitamin C 60 mg, and vitamin E 10 mg bid for the whole follow-up period...
October 8, 2018: Integrative Cancer Therapies
Daniel Cruceriu, Ovidiu Balacescu, Elena Rakosy
A continuous challenge in cancer management is to improve treatment efficacy and to diminish its side effects. Consequently, new conventional and unconventional drugs and bioactive compounds from plants are constantly developed, characterized, and used for in vitro and in vivo models. This review focuses on the antitumor properties of Calendula officinalis, its biological and molecular effects in tumor cells and animal models, as well as its role in cancer palliative care. A systematic review of studies describing the cytotoxic role of C officinalis and its therapeutic role on cancer cells were carried out using the PubMed database...
October 5, 2018: Integrative Cancer Therapies
Elizabeth R Kessler, Lih-Jen Su, Dexiang Gao, Kathleen C Torkko, Michael Wacker, Mary Anduha, Nicole Chronister, Paul Maroni, E David Crawford, Thomas W Flaig, L Michael Glode, Elaine T Lam
BACKGROUND: Plant derivatives have been studied as therapies for prostate cancer based on their purported anti-inflammatory and antioxidant properties and low toxicities. The acai berry is an example of a plant rich in phytochemicals, which may slow the growth of prostate cancer. METHODS: This was a phase II, Simon 2-stage clinical trial in patients with biochemically recurrent prostate cancer with a primary endpoint of prostate-specific antigen (PSA) response. Patients were asymptomatic, with a rising PSA of at least 0...
October 5, 2018: Integrative Cancer Therapies
Szilvia Zörgő, Olga L Olivas Hernández
INTRODUCTION: Complementary and alternative medicine (CAM) use has been increasing in the past decades in tandem with changes regarding the notions of health and illness. Comparing conventional medicine (CM) and CAM in how they address health problems has been a point of focus for both the health sciences and individuals dealing with health problems. Various social, cultural, political, economic, and personal factors play a role in whether different health approaches are integrated or not when addressing illness experiences...
September 26, 2018: Integrative Cancer Therapies
Agata Kabała-Dzik, Anna Rzepecka-Stojko, Robert Kubina, Robert Dariusz Wojtyczka, Ewa Buszman, Jerzy Stojko
Epithelium mammary carcinoma is a cancer with a high death rate among women. One factor having a significant impact on metastasis is cell migration. The aim of this study was to compare migration rate inhibition of caffeic acid (CA) and its phenethyl ester (CAPE) on MCF-7 breast cancer cells. Microscopic evaluation was used to determine the morphology of carcinoma cells, before and after 24-hour treatment with CA and CAPE using a dose of 50 µM. The cytotoxic effect was measured by XTT-NR-SRB assay (tetrazolium hydroxide-neutral red-Sulforhodamine B) for 24-hour and 48-hour periods, using CA and CAPE, with doses of 50 and 100 µM...
September 24, 2018: Integrative Cancer Therapies
Ning Zhang, Long-Rong Wang, Dou-Dou Li, De-Ning Ma, Cheng-Hao Wang, Xi-Gan He, Dong-Mei Gao, Lu Wang, Zhao-You Tang
OBJECTIVE: We had previously proved that insufficient radiofrequency ablation (RFA) could enhance invasiveness and metastasis of hepatocellular carcinoma (HCC) through epithelial-mesenchymal transition (EMT), which is mediated by activating β-catenin signaling. Thus, the aim of the present study was to demonstrate whether the combined treatment of interferon-α (IFN-α) and "Songyou Yin" (SYY) minimizes the pro-metastatic effects of insufficient RFA, as well as to explore its underlying mechanism...
September 20, 2018: Integrative Cancer Therapies
Hongyang Lu, Jing Qin, Na Han, Fajun Xie, Lei Gong, Chenghui Li
BACKGROUND: Irinotecan (CPT-11) can be used as a first-line therapeutic drug against extensive-stage small cell lung cancer (SCLC); it can also be used in second-line treatment for SCLC. CPT-11-induced delayed diarrhea restricts its clinical application. This study aimed to confirm whether Banxia Xiexin decoction was effective in preventing and controlling CPT-11-induced delayed diarrhea. METHODS: A total of 27 patients with recurrent SCLC undergoing chemotherapy regimens including CPT-11 were enrolled for the study...
September 19, 2018: Integrative Cancer Therapies
Denis L Jardim, Débora de Melo Gagliato, Razelle Kurzrock
Immunotherapies are becoming increasingly important in the treatment armamentarium of a variety of malignancies. Immune checkpoint inhibitors are the most representative drugs receiving regulatory approval over the past few years. In a recent study published in Clinical Cancer Research, we demonstrated that these agents are being developed faster than other prior anticancer therapies. All checkpoint inhibitors received priority review, being granted with at least one Food and Drug Administration expedited program...
September 19, 2018: Integrative Cancer Therapies
Ralf Kleef, Ralph Moss, A Marcell Szasz, Arthur Bohdjalian, Hans Bojar, Tibor Bakacs
The prognosis of triple-negative breast cancer with metastases after chemotherapy remains dismal. We report the case of a 50-year-old female with first disease recurrence at the axillary lymph node and, later on, bilateral pulmonary metastases with severe shortness of breath. The patient received low-dose immune checkpoint blockade (concurrent nivolumab and ipilimumab) weekly over 3 weeks with regional hyperthermia 3 times a week, followed by systemic fever-range hyperthermia induced by interleukin-2 for 5 days...
September 7, 2018: Integrative Cancer Therapies
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