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Integrative Cancer Therapies

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https://www.readbyqxmd.com/read/28102098/a-randomized-double-blind-placebo-controlled-trial-of-fruit-and-vegetable-concentrates-on-intermediate-biomarkers-in-head-and-neck-cancer
#1
Mridul Datta, Edward G Shaw, Glenn J Lesser, L Douglas Case, Mara Z Vitolins, Charles Schneider, Bart Frizzell, Christopher Sullivan, Mark Lively, Elizabeth Franzmann, Jennifer J Hu
BACKGROUND: Head and neck cancer (HNC) patients are at an increased risk for developing second primary tumors (SPTs). Diets rich in fruits and vegetables (FVs) may lower HNC risk. FV concentrates may offer a potential alternative to increasing FV intake. METHODS: We conducted a randomized, double-blind, placebo-controlled trial to evaluate whether Juice PLUS+ (JP; a commercial product with multiple FV concentrates) has an effect on p27 and Ki-67, biomarkers associated with the risk of SPTs...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28056563/a-survey-of-licensed-acupuncturists-in-the-san-francisco-bay-area
#2
Donald Abrams, Michael McCulloch, Misha Cohen, Mike Liaw, Deborah Silverman, Carla Wilson
BACKGROUND: Many cancer patients seek traditional Chinese medicine (TCM), the prevalence varying with diagnosis, comorbidities, and demographics. Interventions sought include acupuncture, massage, herbs, diet, and exercise, usually combined with conventional therapies. It is not known what proportion of TCM practitioners care for cancer patients, their cancer specific training or caseload, what interventions they employ, their outcomes, and their communication patterns with conventional oncologists...
January 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27923905/%C3%AE-lapachone-inhibits-lung-metastasis-of-colorectal-cancer-by-inducing-apoptosis-of-ct26-cells
#3
Ji-Ye Kee, Yo-Han Han, Jinbong Park, Dae-Seung Kim, Jeong-Geon Mun, Kwang Seok Ahn, Hyun-Jung Kim, Jae-Young Um, Seung-Heon Hong
BACKGROUND: β-Lapachone is a quinone-containing compound found in red lapacho (Tabebuia impetiginosa, syn. T avellanedae) trees. Lapacho has been used in traditional medicine by several South and Central American indigenous people to treat various types of cancer. The purpose of this study was to investigate the antimetastatic properties of β-lapachone and the underlying mechanisms using colon cancer cells. METHODS: This research used metastatic murine colon cancer cell lines, colon 26 (CT26) and colon 38 (MC38)...
December 5, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27923904/augmentation-of-cytolytic-activity-in-murine-natural-killer-cells-and-inhibition-of-tumor-growth-by-the-ethanol-fraction-of-oyster-extract
#4
Kaito Sakaguchi, Ming Zhong, Saeko Kawai, Yoshio Shimizu, Eiichi Gohda
A reduced number and/or reduced activity of natural killer (NK) cells, which are important for defense against a variety of cancers and viral infections, occur under various stress conditions and in patients with various diseases. In this article, we report that the 30% to 50% ethanol precipitate of oyster extract (EPOE50) dose-dependently enhanced the activity of mouse spleen NK cells in vitro and in vivo. The activity of EPOE50 was eluted with a molecular weight of about 2000 by gel filtration and was inactivated by periodate but not by proteinase K...
December 5, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28088871/herbal-medicine-practices-of-patients-with-liver-cancer-in-peru
#5
Teresa Rojas Rojas, Geneviève Bourdy, Eloy Ruiz, Juan-Pablo Cerapio, Pascal Pineau, Jacques Gardon, Franco Doimi, Xavier Deparis, Eric Deharo, Stéphane Bertani
RATIONALE: The highest burden of liver cancer occurs in developing countries, where the use of herbal medicine (HM) is still widespread. Despite this trend, few studies have been conducted to report HM practices of patients with a hepatic tumor in the developing world. Hence, this study aimed to document the use of HM among patients with liver cancer in Peru. STUDY DESIGN AND METHODS: A comparative behavioral epidemiological survey was conducted among liver cancer patients attending the National Cancer Institute of Peru...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28050925/bone-mineral-density-balance-performance-balance-self-efficacy-and-falls-in-breast-cancer-survivors-with-and-without-qigong-training
#6
Shirley S M Fong, Anna W M Choi, W S Luk, Timothy T T Yam, Joyce C Y Leung, Joanne W Y Chung
PURPOSE: A deterioration in bone strength and balance performance after breast cancer treatment can result in injurious falls. Therefore, interventions need to be developed to improve the bone strength and balance ability of breast cancer survivors. This cross-sectional exploratory study aimed to compare the bone mineral density (BMD), balance performance, balance self-efficacy, and number of falls between breast cancer survivors who practiced qigong, breast cancer survivors who did not practice qigong, and healthy individuals...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28050924/inpatient-acupuncture-at-a-major-cancer-center
#7
M Kay Garcia, Lorenzo Cohen, Michael Spano, Amy Spelman, Yousra Hashmi, Alejandro Chaoul, Qi Wei, Gabriel Lopez
BACKGROUND: Use of complementary and integrative therapies is increasing among cancer patients, but data regarding the impact treatments such as acupuncture have in an inpatient oncology setting are limited. METHODS: Patients who received acupuncture in an inpatient hospital environment between December 2014 and December 2015 were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 0-10 scale) before and after each visit. Pre- and post-treatment scores were examined for each symptom using paired t tests...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28024424/the-relationship-between-health-related-quality-of-life-and-survival-in-metastatic-colorectal-cancer-patients-treated-with-korean-medicine
#8
Sora Park, Wankyu Eo, Sookyung Lee
OBJECTIVES: This study aimed to identify the relationship between health-related quality of life (HRQoL) measured by the Functional Assessment Cancer Therapy-General (FACT-G) and survival in metastatic colorectal cancer (mCRC) patients. METHODS: The clinical characteristics and FACT-G scores were retrospectively reviewed in mCRC patients who visited the Cancer Center of Korean Medicine. The overall survival (OS) was calculated and compared using the Kaplan-Meier method and log-rank test...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28024420/assessing-the-correlation-between-physical-activity-and-quality-of-life-in-advanced-lung-cancer
#9
Brett C Bade, Mary C Brooks, Sloan B Nietert, Ansley Ulmer, D David Thomas, Paul J Nietert, JoAnn B Scott, Gerard A Silvestri
BACKGROUND AND OBJECTIVE: Increasing physical activity (PA) is safe and beneficial in lung cancer (LC) patients. Advanced-stage LC patients are under-studied and have worse symptoms and quality of life (QoL). We evaluated the feasibility of monitoring step count in advanced LC as well as potential correlations between PA and QoL. METHODS: This is a prospective, observational study of 39 consecutive patients with advanced-stage LC. Daily step count over 1 week (via Fitbit Zip), QoL, dyspnea, and depression scores were collected...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28008780/carnosine-inhibits-the-proliferation-of-human-cervical-gland-carcinoma-cells-through-inhibiting-both-mitochondrial-bioenergetics-and-glycolysis-pathways-and-retarding-cell-cycle-progression
#10
Yun Bao, Saidan Ding, Jiaoyan Cheng, Yuan Liu, Bingyu Wang, Huijuan Xu, Yao Shen, Jianxin Lyu
Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the cultured human cervical gland carcinoma cells HeLa and cervical squamous carcinoma cells SiHa. The results showed that carnosine exerted a significant inhibitory effect on the proliferation of HeLa cells, whereas its inhibitory action on the proliferation of SiHa cells was much weaker...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28008779/the-effect-of-undaria-pinnatifida-fucoidan-on-the-pharmacokinetics-of-letrozole-and-tamoxifen-in-patients-with-breast-cancer
#11
Shreya Tocaciu, Lesley J Oliver, Ray M Lowenthal, Gregory M Peterson, Rahul Patel, Madhur Shastri, Georgia McGuinness, Inger Olesen, J Helen Fitton
BACKGROUND: Although the use of complementary and alternative medicines is widespread in cancer patients, clinical evidence of their benefits is sparse. Furthermore, while they are often assumed to be safe with regard to concurrent use of anticancer therapies, few studies have been carried out to investigate possible interactions. Fucoidans are a group of sulfated carbohydrates, derived from marine brown algae, which have long been used as dietary supplements due to their reported medicinal properties, including anticancer activity...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28008778/physical-activity-during-and-after-adjuvant-treatment-for-breast-cancer
#12
Maria Browall, Sara Mijwel, Helen Rundqvist, Yvonne Wengström
BACKGROUND: In oncology, physical activity (PA) is recognized to improve psychological and physiological functions. Motivating women with breast cancer to sustain a physically active lifestyle is important for promoting positive health after diagnosis. To review and synthesize what is known about how women with breast cancer experience supervised and unsupervised PA during and after adjuvant treatment. PubMed, PsycINFO, and CINAHL were searched, yielding 994 citations. The final review included 17 articles published between 2004 and 2014 in English...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903842/a-comprehensive-lifestyle-randomized-clinical-trial-design-and-initial-patient-experience
#13
Banu Arun, Taylor Austin, Gildy V Babiera, Karen Basen-Engquist, Cindy L Carmack, Alejandro Chaoul, Lorenzo Cohen, Lisa Connelly, Robin Haddad, Carol Harrison, Yisheng Li, Smitha Mallaiah, Raghuram Nagarathna, Patricia A Parker, George H Perkins, James M Reuben, Ya-Chen Tina Shih, Amy Spelman, Anil Sood, Peiying Yang, Sai-Ching J Yeung
BACKGROUND: Although epidemiological research demonstrates that there is an association between lifestyle factors and risk of breast cancer recurrence, progression of disease, and mortality, no comprehensive lifestyle change clinical trials have been conducted to determine if changing multiple risk factors leads to changes in biobehavioral processes and clinical outcomes in women with breast cancer. This article describes the design, feasibility, adherence to the intervention and data collection, and patient experience of a comprehensive lifestyle change clinical trial (CompLife)...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903841/influence-of-a-moderate-intensity-exercise-program-on-early-nk-cell-immune-recovery-in-pediatric-patients-after-reduced-intensity-hematopoietic-stem-cell-transplantation
#14
Carolina Chamorro-Viña, Jaime Valentín, Lucía Fernández, Marta González-Vicent, Margarita Pérez-Ruiz, Alejandro Lucía, S Nicole Culos-Reed, Miguel Ángel Díaz, Antonio Pérez-Martínez
INTRODUCTION: After allogeneic hematopoietic stem cell transplantation (HSCT), NK cell reconstitution, which is crucial for positive outcomes, is dominated by the CD56(bright) subset with low NK cell cytotoxicity (NKCC) activity. Moderate exercise has been described as a potent NK cell stimulus in adults with cancer. PURPOSE: To determine the effects of a moderate-intensity exercise program on NK cell recovery early after HSCT and the feasibility of this intervention...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#15
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27899698/illuminating-a-risk-for-breast-cancer-a-preliminary-ecological-study-on-the-association-between-streetlight-and-breast-cancer
#16
Atalya Keshet-Sitton, Keren Or-Chen, Eran Huber, Abraham Haim
Artificial light at night (ALAN) for elongating photophase is a new source of pollution. We examined the association between measured ALAN levels and breast cancer (BC) standard morbidity ratio (SMR) at a statistical area (SA) level in an urban environment. Sample size consisted of 266 new BC cases ages 35-74. Light measurements (lux) were performed in 11 SAs. A new calculated variable of morbidity per SA size (SMR35-74/km(2)) was correlated with the light variables per road length, using Pearson correlations (P < ...
November 29, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27879377/promising-compounds-from-murraya-exotica-for-cancer-metastasis-chemoprevention
#17
Su-Dan He, Xing-Tian Yang, Cui-Cui Yan, Zhou Jiang, Su-Hong Yu, Yu-Yang Zhou, Lee Jia
Most of the present anticancer drugs are highly cytotoxic and focus mainly on killing tumor cells rather than slowing the progress of cancer metastasis. Evidence has been reported that bridges the mechanisms of inflammation and tumor invasion. Therefore, we evaluated the potency in cancer metastasis chemoprevention of compounds and a coumarin extracted from Murraya exotica, which is known for its anti-inflammation bioactivity. By carrying out experiments in vitro, we found the root extracts more efficient than the leaf extracts in restraining cell migration of MDA-MB-231 cells, while leaf extracts presented slightly stronger inhibition of tumor cell adhesion at low concentrations...
November 21, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27879376/the-fractionated-toona-sinensis-leaf-extract-induces-apoptosis-of-human-osteosarcoma-cells-and-inhibits-tumor-growth-in-a-murine-xenograft-model
#18
Chung-Hwan Chen, Ching-Ju Li, I-Chun Tai, Xiao-Hui Lin, Hseng-Kuang Hsu, Mei-Ling Ho
BACKGROUND: Osteosarcoma is a malignant bone tumor prevalent in adolescents with poor prognosis. Toona sinensis showed potent antiproliferation effect on lung, melatonin, ovary, colon, and liver cancers. However, the effects of the species on osteosarcoma cells are rarely investigated. RESULTS: In this study, we found fraction 1 of Toona sinensis leaf (TSL-1) resulted in inhibition of cell viability in MG-63, Saos-2, and U2OS osteosarcoma cell lines, while it only caused a moderate suppressive effect on normal osteoblasts...
November 21, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27879375/the-role-of-oxidative-stress-in-koenimbine-induced-dna-damage-and-heat-shock-protein-modulation-in-hepg2-cells
#19
Yahya Hasan Hobani
Murraya koenigii (L.) Spreng, is a significant herb of traditional Ayurvedic system of medicine. Koenimbine, a carbazole alkaloid isolated from this plant holds antiproliferative and apoptotic effects. The aim of this study was to assess koenimbine-induced DNA damage and to clarify the role of free radicals in cell death mechanisms, using HepG2 cells. Methods The level of cytotoxicity was assayed by MTT assay. To elucidate the role of glutathione (GSH), the intracellular GSH level was analyzed. The effect of koenimbine in the cell mitochondria was evaluated using mitochondrial membrane potential (MMP) changes...
November 21, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27821721/coenzyme-q0-enhances-ultraviolet-b-induced-apoptosis-in-human-estrogen-receptor-positive-breast-mcf-7-cancer-cells
#20
Hui-Min Wang, Hsin-Ling Yang, Varadharajan Thiyagarajan, Tzu-Hsiang Huang, Pei-Jane Huang, Ssu-Ching Chen, Jer-Yuh Liu, Li-Sung Hsu, Hsueh-Wei Chang, You-Cheng Hseu
Coenzyme Q0 (CoQ0; 2,3-dimethoxy-5-methyl-1,4-benzoquinone), a major active constituent of Antrodia camphorata, has been shown to inhibit human triple-negative breast cancer (MDA-MB-231) cells through induction of apoptosis and cell-cycle arrest. Ecological studies have suggested a possible association between ultraviolet B (UVB) radiation and reduction in the risk of breast cancer. However, the underlying mechanism of the combination of CoQ0 and UVB in human estrogen receptor-positive breast cancer (MCF-7) remains unclear...
November 7, 2016: Integrative Cancer Therapies
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