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Expert Opinion on Therapeutic Targets

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https://www.readbyqxmd.com/read/28609155/leucine-rich-repeat-kinase-2-beyond-parkinson-s-and-beyond-kinase-inhibitors
#1
Susanna Cogo, Elisa Greggio, Patrick A Lewis
No abstract text is available yet for this article.
June 22, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28537457/inhibition-of-mtor-kinase-as-a-therapeutic-target-for-acute-myeloid-leukemia
#2
Yoko Tabe, Agostino Tafuri, Kazumasa Sekihara, Haeun Yang, Marina Konopleva
Acute myeloid leukemia (AML), the most common acute leukemia in adults, remains a therapeutic challenge. The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway is one of the key aberrant intracellular axes involved in AML. Areas covered: mTOR plays a critical role in sensing and responding to environmental determinants such as nutrient availability, stress, and growth factor concentrations; and in modulating key cellular functions such as proliferation, metabolism, and survival...
June 9, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28524744/sphingosine-1-phosphate-signaling-in-bone-remodeling-multifaceted-roles-and-therapeutic-potential
#3
Anastasia Meshcheryakova, Diana Mechtcheriakova, Peter Pietschmann
Sphingolipids belong to a complex class of lipid molecules that are crucially involved in the regulation of important biological processes including proliferation, migration and apoptosis. Given the significant progress made in understanding the sphingolipid pathobiology of several diseases, sphingolipid-related checkpoints emerge as attractive targets. Recent data indicate the multifaceted contribution of the sphingolipid machinery to osteoclast - osteoblast crosstalk, representing one of the pivotal interactions underlying bone homeostasis...
June 7, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28548025/reprogramming-the-oncogenic-response-set-protein-as-a-potential-therapeutic-target-in-cancer
#4
Man-Hsin Hung, Kuen-Feng Chen
SET is a multitask oncoprotein that promotes the initiation and progression of cancer. Overexpression of SET has been characterized as being tumor-specific and is associated with adverse clinical outcomes in many different human malignant diseases. Notably, SET has been shown to promote the development of therapeutic resistance in cancer cells. Area covered: In this review, we summarized the currently available evidence relating to the oncogenic roles, biological functions and clinical relevance of SET protein in cancer...
June 6, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28553732/hypoxia-inducible-factor-1%C3%AE-a-promising-therapeutic-target-for-autoimmune-diseases
#5
Shi-Yang Guan, Rui-Xue Leng, Jin-Hui Tao, Xiang-Pei Li, Dong-Qing Ye, Nancy Olsen, Song Guo Zheng, Hai-Feng Pan
Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases. Areas covered: Considering that the types of autoimmune diseases are complicated and various, this review aims to cover the typical kinds of autoimmune diseases, discuss the molecular mechanisms, biological functions and expression of HIF-1α in these diseases, and further explore its therapeutic potential...
June 5, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28562118/mif-family-cytokines-in-cardiovascular-diseases-and-prospects-for-precision-based-therapeutics
#6
Pathricia V Tilstam, Dake Qi, Lin Leng, Lawrence Young, Richard Bucala
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions that is being increasingly studied in different aspects of cardiovascular disease. MIF was first identified as a proinflammatory and pro-survival mediator within the immune system, and a second structurally related MIF family member, D-dopachrome tautomerase (a.k.a. MIF-2), was reported recently. Both MIF family members are released by myocardium and modulate the manifestations of cardiovascular disease, specifically in myocardial ischemia...
May 31, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28460571/muc4-mucin-a-therapeutic-target-for-pancreatic-ductal-adenocarcinoma
#7
Shailendra K Gautam, Sushil Kumar, Andrew Cannon, Bradley Hall, Rakesh Bhatia, Mohd Wasim Nasser, Sidharth Mahapatra, Surinder K Batra, Maneesh Jain
Pancreatic cancer (PC) is characterized by mucin overexpression. MUC4 is the most differentially overexpressed membrane-bound mucin that plays a functional role in disease progression and therapy resistance. Area covered: We describe the clinicopathological significance of MUC4, summarize mechanisms contributing to its deregulated expression, review preclinical studies aimed at inhibiting MUC4, and discuss how MUC4 overexpression provides opportunities for developing targeted therapies. Finally, we discuss the challenges for developing MUC4-based therapeutics, and identify areas where efforts should be directed to effectively exploit MUC4 as a therapeutic target for PC...
May 29, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28494625/s100-alarmins-potential-therapeutic-targets-for-arthritis
#8
Judith Austermann, Stefanie Zenker, Johannes Roth
In arthritis, inflammatory processes are triggered by numerous factors that are released from joint tissues, promoting joint destruction and pathological progression. During inflammation, a novel family of pro-inflammatory molecules called alarmins is released, amplifying inflammation and joint damage. Areas covered: With regard to the role of the alarmins S100A8 and S100A9 in the pathogenesis of arthritis, recent advances and the future prospects in terms of therapeutic implications are considered. Expert opinion: There is still an urgent need for novel treatment strategies addressing the local mechanisms of joint inflammation and tissue destruction, offering promising therapeutic alternatives...
May 25, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28490207/microrna-124-a-putative-therapeutic-target-and-biomarker-for-major-depression
#9
Yogesh Dwivedi
No abstract text is available yet for this article.
May 25, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28480765/targeting-dorsal-root-ganglia-and-primary-sensory-neurons-for-the-treatment-of-chronic-pain
#10
Temugin Berta, Yawar Qadri, Ping-Heng Tan, Ru-Rong Ji
Currently the treatment of chronic pain is inadequate and compromised by debilitating central nervous system side effects. Here we discuss new therapeutic strategies that target dorsal root ganglia (DRGs) in the peripheral nervous system for a better and safer treatment of chronic pain. Areas covered: The DRGs contain the cell bodies of primary sensory neurons including nociceptive neurons. After painful injuries, primary sensory neurons demonstrate maladaptive molecular changes in DRG cell bodies and in their axons...
May 16, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28372474/corrigendum
#11
(no author information available yet)
No abstract text is available yet for this article.
April 3, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28338356/the-accessory-gene-regulator-1-as-a-therapeutic-target-for-c-difficile-infections
#12
Charles Darkoh, Herbert L DuPont
No abstract text is available yet for this article.
April 3, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28472892/type-ii-nadh-dehydrogenase-ndh-2-a-promising-therapeutic-target-for-antitubercular-and-antibacterial-drug-discovery
#13
REVIEW
Satheeshkumar Sellamuthu, Meenakshi Singh, Ashok Kumar, Sushil Kumar Singh
Tuberculosis (TB) is highly dangerous due to the development of resistance to first-line drugs. Moreover, Mycobacterium tuberculosis (Mtb) has also developed resistance to newly approved antitubercular drug bedaquiline. This necessitates the search for drugs acting on newer molecular targets. The energy metabolism of mycobacteria is the prime focus for the discovery of novel antitubercular drugs. Targeting type-2 NADH dehydrogenase (NDH-2) involved in the production of respiratory ATP could, therefore, be effective in treating the disease...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28443359/targeting-lrrk2-in-parkinson-s-disease-an-update-on-recent-developments
#14
REVIEW
Sharon L Chan, Eng-King Tan
LRRK2 research has progressed significantly in recent years with more reports of LRRK2 interactors and the development of more specific and sophisticated LRRK2 kinase inhibitors. Identification of bone fide LRRK2 substrates will provide new therapeutic targets in LRRK2-linked Parkinson's disease (PD). Areas covered: This review aims to put current LRRK2 research into perspective. Beginning with recent LRRK2 mammalian models employed for in vivo validation of LRRK2 substrates, followed by updates on reported LRRK2 interactors and their inferred mechanisms...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28441889/insight-on-the-impacts-of-free-amino-acids-and-their-metabolites-on-the-immune-system-from-a-perspective-of-inborn-errors-of-amino-acid-metabolism
#15
REVIEW
Malgorzata M Pakula, Thorsten J Maier, Thomas Vorup-Jensen
Amino acids (AAs) support a broad range of functions in living organisms, including several that affect the immune system. The functions of the immune system are affected when free AAs are depleted or in excess because of external factors, such as starvation, or because of genetic factors, such as inborn errors of metabolism. Areas covered: In this review, we discuss the current insights into how free AAs affect immune responses. When possible, we make comparisons to known disease states resulting from inborn errors of metabolism, in which changed levels of AAs or AA metabolites provide insight into the impact of AAs on the human immune system in vivo...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28434268/ubiquitin-c-terminal-hydrolase-l1-uch-l1-as-a-therapeutic-and-diagnostic-target-in-neurodegeneration-neurotrauma-and-neuro-injuries
#16
REVIEW
Kevin K Wang, Zhihui Yang, George Sarkis, Isabel Torres, Vijaya Raghavan
Since its discovery as a major CNS-abundant protein 25 years ago, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has emerged as an important enzyme in regulating brain protein metabolism, by coupling to the proteasome pathway of protein degradation. Areas covered: UCH-L1 is implicated in both familial and sporadic Parkinson disease and other chronic neurodegenerative diseases. Also, UCH-L1 has been recently emerging as a biofluid-based biomarker for various forms of acute neurotrauma and CNS injury. Expert opinion: The loss of UCH-L1 activity coupled with the gain of proteinopathy function are linked to neurodegeneration such as Parkinsonism and Alzheimer's disease...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28434262/the-emergence-of-acid-ceramidase-as-a-therapeutic-target-for-acute-myeloid-leukemia
#17
REVIEW
Su-Fern Tan, Jennifer M Pearson, David J Feith, Thomas P Loughran
Acute myeloid leukemia (AML) is the most common adult leukemia. Only a fraction of AML patients will survive with existing chemotherapy regimens. Hence, there is an urgent and unmet need to identify novel targets and develop better therapeutics in AML. In the past decade, the field of sphingolipid metabolism has emerged into the forefront of cancer biology due to its importance in cancer cell proliferation and survival. In particular, acid ceramidase (AC) has emerged as a promising therapeutic target due to its role in neutralizing the pro-death effects of ceramide...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28406715/competitive-endogenous-rna-network-potential-implication-for-systemic-lupus-erythematosus
#18
REVIEW
Lian-Ju Li, Wei Zhao, Sha-Sha Tao, Rui-Xue Leng, Yin-Guang Fan, Hai-Feng Pan, Dong-Qing Ye
Competitive endogenous RNA (ceRNA) hypothesis proposes that RNA transcripts, both coding and non-coding, crosstalk with and coregulate each other using microRNA response elements (MREs). CeRNA analysis tremendously expands functional information of coding and non-coding RNAs. Mounting evidence have shown that various types of RNAs, including pseudogenes, long non-coding RNAs, circular RNAs, and messenger RNAs, can function as ceRNAs in distinct physiological and pathophysiological states. Many validated ceRNA pairs participate in the initiation and progression of cancers, and systemic ceRNA network analyses revealing potential of ceRNAs in diagnosis, therapy, and prognosis of cancers have also been performed...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28406046/depdc5-as-a-potential-therapeutic-target-for-epilepsy
#19
REVIEW
Kenneth A Myers, Ingrid E Scheffer
Dishevelled, Egl-10 and Pleckstrin (DEP) domain-containing protein 5 (DEPDC5) is a protein subunit of the GTPase-activating proteins towards Rags 1 (GATOR1) complex. GATOR1 is a recently identified modulator of mechanistic target of rapamycin (mTOR) activity. mTOR is a key regulator of cell proliferation and metabolism; disruption of the mTOR pathway is implicated in focal epilepsy, both acquired and genetic. Tuberous sclerosis is the prototypic mTOR genetic syndrome with epilepsy, however GATOR1 gene mutations have recently been shown to cause lesional and non-lesional focal epilepsy...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28395542/targetting-ped-pea-15-for-diabetes-treatment
#20
REVIEW
Francesca Fiory, Rosa Spinelli, Gregory Alexander Raciti, Luca Parrillo, Vittoria D'esposito, Pietro Formisano, Claudia Miele, Francesco Beguinot
PED/PEA-15 is an ubiquitously expressed protein, involved in the regulation of proliferation and apoptosis. It is commonly overexpressed in Type 2 Diabetes (T2D) and in different T2D-associated comorbidities, including cancer and certain neurodegenerative disorders. Areas covered: In mice, Ped/Pea-15 overexpression impairs glucose tolerance and, in combination with high fat diets, further promotes insulin resistance and T2D. It also controls β-cell mass, altering caspase-3 activation and the expression of pro- and antiapoptotic genes...
June 2017: Expert Opinion on Therapeutic Targets
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