journal
MENU ▼
Read by QxMD icon Read
search

Expert Opinion on Therapeutic Targets

journal
https://www.readbyqxmd.com/read/28670929/exploiting-the-pro-apoptotic-function-of-noxa-as-a-therapeutic-modality-in-cancer
#1
Jeroen E Guikema, Martine Amiot, Eric Eldering
Direct targeting of Bcl-2 members for therapeutic purposes in cancer has become a clinical reality with the FDA approval of ABT-199/Venetoclax. Other highly specific BH3-mimetics are in pre-clinical development. Understanding the functional interactions among the Bcl-2 family is of prime importance to fully exploit their potential. NOXA is considered a rather weak BH3-only member but it has unexplored potential in various settings, which are of relevance in cancer. NOXA is best known as a selective inhibitor of MCL1, itself overexpressed in many cancers, and this protein pair forms an important rheostat in many forms of cell stress...
July 18, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28664757/trap1-a-viable-therapeutic-target-for-future-cancer-treatments
#2
Giacomo Lettini, Francesca Maddalena, Lorenza Sisinni, Valentina Condelli, Danilo Swann Matassa, Maria Paola Costi, Daniele Simoni, Franca Esposito, Matteo Landriscina
HSP90 molecular chaperones (i.e., HSP90α, HSP90β, GRP94 and TRAP1) are potential therapeutic targets to design novel anticancer agents. However, despite numerous designed HSP90 inhibitors, most of them have failed due to unfavorable toxicity profiles and lack of specificity toward different HSP90 paralogs. Indeed, a major limitation in this field is the high structural homology between different HSP90 chaperones, which significantly limits our capacity to design paralog-specific inhibitors. Area covered: This review examines the relevance of TRAP1 in tumor development and progression, with an emphasis on its oncogenic/oncosuppressive role in specific human malignancies and its multifaceted and context-dependent functions in cancer cells...
July 18, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28685641/sleep-disturbances-and-severe-stress-as-glial-activators-key-targets-for-treating-central-sensitization-in-chronic-pain-patients
#3
Jo Nijs, Marco L Loggia, Andrea Polli, Maarten Moens, Eva Huysmans, Lisa Goudman, Mira Meeus, Luc Vanderweeën, Kelly Ickmans, Daniel Clauw
The mechanism of sensitization of the central nervous system partly explains the chronic pain experience in many patients, but the etiological mechanisms of this central nervous system dysfunction are poorly understood. Recently, an increasing number of studies suggest that aberrant glial activation takes part in the establishment and/or maintenance of central sensitization. Areas covered: This review focused on preclinical work and mostly on the neurobiochemistry studied in animals, with limited human studies available...
July 12, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28679296/pharmacological-targeting-of-spak-kinase-in-disorders-of-impaired-epithelial-transport
#4
Jinwei Zhang, Jason K Karimy, Eric Delpire, Kristopher T Kahle
The mammalian SPS1-related proline/alanine-rich serine-threonine kinase SPAK (STK39) modulates ion transport across and between epithelial cells in response to environmental stimuli such osmotic stress and inflammation. Research over the last decade has established a central role for SPAK in the regulation of ion and water transport in the distal nephron, colonic crypts, and pancreatic ducts, and has implicated deregulated SPAK signaling in NaCl-sensitive hypertension, ulcerative colitis and Crohn's disease, and cystic fibrosis...
July 12, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28671018/gper-1-gpr30-a-novel-estrogen-receptor-sited-in-the-cell-membrane-therapeutic-coupling-to-breast-cancer
#5
Luis Molina, Carlos D Figueroa, Kanti D Bhoola, Pamela Ehrenfeld
Breast cancer is clinically classified as 'estrogen-positive' when at least 1% of cancer cells stain for the estrogen receptor alpha (ERα). However, recent research on both basic and clinical aspects of breast cancer suggests that GPER-1 (G protein-coupled estrogen receptor-1) may have an important role in breast cancer. Areas covered: This review provides a comprehensive and systematic literature search on GPER-1. We have focused on the role of GPER-1 in breast cancer and on resistance to endocrine therapy, an unsolved clinical issue still under discussion...
July 12, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28675319/nrf2-a-potential-therapeutic-target-for-naturally-occurring-anticancer-drugs
#6
Elena Catanzaro, Cinzia Calcabrini, Eleonora Turrini, Piero Sestili, Carmela Fimognari
Nuclear factor (erythroid-derived-2)-like 2 is one of the most efficient cytoprotective rheostats against exogenous or endogenous oxidative insults. At present, the modulation of the Nrf2 pathway represents an interesting and highly explored strategy in the oncological area. Area covered: In this review, we present and discuss the different modulation of the Nrf2 pathway by some natural compounds with a well demonstrated anticancer activity, and critically analyze the challenges associated with the development of an Nrf2-based anticancer strategy...
July 10, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28609155/leucine-rich-repeat-kinase-2-beyond-parkinson-s-and-beyond-kinase-inhibitors
#7
Susanna Cogo, Elisa Greggio, Patrick A Lewis
No abstract text is available yet for this article.
June 22, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28490207/microrna-124-a-putative-therapeutic-target-and-biomarker-for-major-depression
#8
Yogesh Dwivedi
No abstract text is available yet for this article.
May 25, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28562118/mif-family-cytokines-in-cardiovascular-diseases-and-prospects-for-precision-based-therapeutics
#9
REVIEW
Pathricia V Tilstam, Dake Qi, Lin Leng, Lawrence Young, Richard Bucala
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions that increasingly is being studied in different aspects of cardiovascular disease. MIF was first identified as a proinflammatory and pro-survival mediator within the immune system, and a second structurally related MIF family member, D-dopachrome tautomerase (a.k.a. MIF-2), was reported recently. Both MIF family members are released by myocardium and modulate the manifestations of cardiovascular disease, specifically in myocardial ischemia...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28553732/hypoxia-inducible-factor-1%C3%AE-a-promising-therapeutic-target-for-autoimmune-diseases
#10
REVIEW
Shi-Yang Guan, Rui-Xue Leng, Jin-Hui Tao, Xiang-Pei Li, Dong-Qing Ye, Nancy Olsen, Song Guo Zheng, Hai-Feng Pan
Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases. Areas covered: Considering that the types of autoimmune diseases are complicated and various, this review aims to cover the typical kinds of autoimmune diseases, discuss the molecular mechanisms, biological functions and expression of HIF-1α in these diseases, and further explore its therapeutic potential...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28548025/reprogramming-the-oncogenic-response-set-protein-as-a-potential-therapeutic-target-in-cancer
#11
REVIEW
Man-Hsin Hung, Kuen-Feng Chen
SET is a multitask oncoprotein that promotes the initiation and progression of cancer. Overexpression of SET has been characterized as being tumor-specific and is associated with adverse clinical outcomes in many different human malignant diseases. Notably, SET has been shown to promote the development of therapeutic resistance in cancer cells. Area covered: In this review, we summarized the currently available evidence relating to the oncogenic roles, biological functions and clinical relevance of SET protein in cancer...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28537457/inhibition-of-mtor-kinase-as-a-therapeutic-target-for-acute-myeloid-leukemia
#12
REVIEW
Yoko Tabe, Agostino Tafuri, Kazumasa Sekihara, Haeun Yang, Marina Konopleva
Acute myeloid leukemia (AML), the most common acute leukemia in adults, remains a therapeutic challenge. The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway is one of the key aberrant intracellular axes involved in AML. Areas covered: mTOR plays a critical role in sensing and responding to environmental determinants such as nutrient availability, stress, and growth factor concentrations; and in modulating key cellular functions such as proliferation, metabolism, and survival...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28524744/sphingosine-1-phosphate-signaling-in-bone-remodeling-multifaceted-roles-and-therapeutic-potential
#13
REVIEW
Anastasia Meshcheryakova, Diana Mechtcheriakova, Peter Pietschmann
Sphingolipids belong to a complex class of lipid molecules that are crucially involved in the regulation of important biological processes including proliferation, migration and apoptosis. Given the significant progress made in understanding the sphingolipid pathobiology of several diseases, sphingolipid-related checkpoints emerge as attractive targets. Recent data indicate the multifaceted contribution of the sphingolipid machinery to osteoclast - osteoblast crosstalk, representing one of the pivotal interactions underlying bone homeostasis...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28494625/s100-alarmins-potential-therapeutic-targets-for-arthritis
#14
REVIEW
Judith Austermann, Stefanie Zenker, Johannes Roth
In arthritis, inflammatory processes are triggered by numerous factors that are released from joint tissues, promoting joint destruction and pathological progression. During inflammation, a novel family of pro-inflammatory molecules called alarmins is released, amplifying inflammation and joint damage. Areas covered: With regard to the role of the alarmins S100A8 and S100A9 in the pathogenesis of arthritis, recent advances and the future prospects in terms of therapeutic implications are considered. Expert opinion: There is still an urgent need for novel treatment strategies addressing the local mechanisms of joint inflammation and tissue destruction, offering promising therapeutic alternatives...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28480765/targeting-dorsal-root-ganglia-and-primary-sensory-neurons-for-the-treatment-of-chronic-pain
#15
REVIEW
Temugin Berta, Yawar Qadri, Ping-Heng Tan, Ru-Rong Ji
Currently the treatment of chronic pain is inadequate and compromised by debilitating central nervous system side effects. Here we discuss new therapeutic strategies that target dorsal root ganglia (DRGs) in the peripheral nervous system for a better and safer treatment of chronic pain. Areas covered: The DRGs contain the cell bodies of primary sensory neurons including nociceptive neurons. After painful injuries, primary sensory neurons demonstrate maladaptive molecular changes in DRG cell bodies and in their axons...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28460571/muc4-mucin-a-therapeutic-target-for-pancreatic-ductal-adenocarcinoma
#16
REVIEW
Shailendra K Gautam, Sushil Kumar, Andrew Cannon, Bradley Hall, Rakesh Bhatia, Mohd Wasim Nasser, Sidharth Mahapatra, Surinder K Batra, Maneesh Jain
Pancreatic cancer (PC) is characterized by mucin overexpression. MUC4 is the most differentially overexpressed membrane-bound mucin that plays a functional role in disease progression and therapy resistance. Area covered: We describe the clinicopathological significance of MUC4, summarize mechanisms contributing to its deregulated expression, review preclinical studies aimed at inhibiting MUC4, and discuss how MUC4 overexpression provides opportunities for developing targeted therapies. Finally, we discuss the challenges for developing MUC4-based therapeutics, and identify areas where efforts should be directed to effectively exploit MUC4 as a therapeutic target for PC...
July 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28472892/type-ii-nadh-dehydrogenase-ndh-2-a-promising-therapeutic-target-for-antitubercular-and-antibacterial-drug-discovery
#17
REVIEW
Satheeshkumar Sellamuthu, Meenakshi Singh, Ashok Kumar, Sushil Kumar Singh
Tuberculosis (TB) is highly dangerous due to the development of resistance to first-line drugs. Moreover, Mycobacterium tuberculosis (Mtb) has also developed resistance to newly approved antitubercular drug bedaquiline. This necessitates the search for drugs acting on newer molecular targets. The energy metabolism of mycobacteria is the prime focus for the discovery of novel antitubercular drugs. Targeting type-2 NADH dehydrogenase (NDH-2) involved in the production of respiratory ATP could, therefore, be effective in treating the disease...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28443359/targeting-lrrk2-in-parkinson-s-disease-an-update-on-recent-developments
#18
REVIEW
Sharon L Chan, Eng-King Tan
LRRK2 research has progressed significantly in recent years with more reports of LRRK2 interactors and the development of more specific and sophisticated LRRK2 kinase inhibitors. Identification of bone fide LRRK2 substrates will provide new therapeutic targets in LRRK2-linked Parkinson's disease (PD). Areas covered: This review aims to put current LRRK2 research into perspective. Beginning with recent LRRK2 mammalian models employed for in vivo validation of LRRK2 substrates, followed by updates on reported LRRK2 interactors and their inferred mechanisms...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28441889/insight-on-the-impacts-of-free-amino-acids-and-their-metabolites-on-the-immune-system-from-a-perspective-of-inborn-errors-of-amino-acid-metabolism
#19
REVIEW
Malgorzata M Pakula, Thorsten J Maier, Thomas Vorup-Jensen
Amino acids (AAs) support a broad range of functions in living organisms, including several that affect the immune system. The functions of the immune system are affected when free AAs are depleted or in excess because of external factors, such as starvation, or because of genetic factors, such as inborn errors of metabolism. Areas covered: In this review, we discuss the current insights into how free AAs affect immune responses. When possible, we make comparisons to known disease states resulting from inborn errors of metabolism, in which changed levels of AAs or AA metabolites provide insight into the impact of AAs on the human immune system in vivo...
June 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28434268/ubiquitin-c-terminal-hydrolase-l1-uch-l1-as-a-therapeutic-and-diagnostic-target-in-neurodegeneration-neurotrauma-and-neuro-injuries
#20
REVIEW
Kevin K Wang, Zhihui Yang, George Sarkis, Isabel Torres, Vijaya Raghavan
Since its discovery as a major CNS-abundant protein 25 years ago, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has emerged as an important enzyme in regulating brain protein metabolism, by coupling to the proteasome pathway of protein degradation. Areas covered: UCH-L1 is implicated in both familial and sporadic Parkinson disease and other chronic neurodegenerative diseases. Also, UCH-L1 has been recently emerging as a biofluid-based biomarker for various forms of acute neurotrauma and CNS injury. Expert opinion: The loss of UCH-L1 activity coupled with the gain of proteinopathy function are linked to neurodegeneration such as Parkinsonism and Alzheimer's disease...
June 2017: Expert Opinion on Therapeutic Targets
journal
journal
39856
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"