Romina Kaveh-Ahangaran, Mohammad Abdollahi, Mohammad Vaezi, Amir Kasaeian, Zhalleh Bahlouli, Ghasem Janbabaei, Amirmahdi Mojtahedzadeh, Mojtaba Mojtahedzadeh, Shirin Djalalinia, Bita Shahrami
OBJECTIVE: Urine alkalinization prevents nephrotoxicity in patients receiving high-dose methotrexate (HDMTX). While the standard approach involves IV sodium bicarbonate, alternative oral bicarbonate regimens are crucial in drug shortages and outpatient settings. This study aims to review the efficacy and safety of such regimens. METHODS: PubMed, WOS, and Scopus were systematically searched using the PRISMA protocol for relevant studies involving human subjects, including randomized clinical trials, retrospective, prospective, cohort, case reports, and case series studies...
January 17, 2024: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences