journal
MENU ▼
Read by QxMD icon Read
search

Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences

journal
https://www.readbyqxmd.com/read/30411191/anticancer-potential-of-ferula-hezarlalehzarica-y-ajani-fraction-in-raji-lymphoma-cell-line-induction-of-apoptosis-cell-cycle-arrest-and-changes-in-mitochondrial-membrane-potential
#1
Yahya Asemani, Abbas Azadmehr, Reza Hajiaghaee, Zahra Amirghofran
BACKGROUND: Cancer is a major cause of mortality. The present study evaluates the antitumor effects of Ferula hezarlalehzarica Y. Ajani fractions on various cancer cell lines, including the Raji Burkitt's lymphoma cells. METHODS: We evaluated the cytotoxic activity of various fractions of F. hezarlalehzarica against tumor cell lines by the MTT assay. Annexin V-PE/7-AAD and cell cycle analysis were assessed by flow cytometry. Expressions of genes associated with cell death and proliferation (Bax, Bcl-2, Fas, and c-Myc) were determined using real-time PCR...
November 9, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30402721/new-mechanisms-of-phenytoin-in-calcium-homeostasis-competitive-inhibition-of-cd38-in-hippocampal-cells
#2
Leila Sadeghi, Reza Yekta, Gholamreza Dehghan
PURPOSE: Phenytoin is a major anticonvulsant drug that is effective to improve arrhythmia and neuropathic pain. According to early works, phenytoin affected cell membrane depolarization by sodium channel blocking, guanylyl and adenylyl cyclase suppression that cause to intracellular Na+ and Ca2+ downregulation. This study was aimed to clarify some ambiguities in pathophysiological action of phenytoin by in vitro and molecular docking analyses. METHODS: In this study intracellular free Ca2+ of primary culture of embryonic mouse hippocampus evaluated via Fura 2 as fluorescent probe...
November 6, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30392156/n-substituted-piperazinyl-sarafloxacin-derivatives-synthesis-and-in-vitro-antibacterial-evaluation
#3
Ali Asadipour, Mohammad Hassan Moshafi, Leila Khosravani, Setareh Moghimi, Elham Amou, Loghman Firoozpour, Ghazaleh Ilbeigi, Keivan Beiki, Ehsan Soleimani, Alireza Foroumadi
BACKGROUND: Fluoroquinolones (FQs) are compounds of major interest with broad antimicrobial activities against community and hospital-acquired infections such as respiratory tract infections (nosocomial pneumonia, chronic bronchitis and tuberculosis), skin and soft tissue infections, bone and joint infections, intra-abdominal infections and sexually transmitted diseases. This broad range of activities along with favorable pharmacokinetic and low toxicity introduced this class of compounds as important antimicrobial chemotherapy agents...
November 3, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30386982/nicotinamide-loaded-functionalized-solid-lipid-nanoparticles-improves-cognition-in-alzheimer-s-disease-animal-model-by-reducing-tau-hyperphosphorylation
#4
Molood Alsadat Vakilinezhad, Azadeh Amini, Hamid Akbari Javar, Batool Faegheh Baha'addini Beigi Zarandi, Hashem Montaseri, Rassoul Dinarvand
BACKGROUND: Nicotinamide is considered to be effective in halting the Alzheimer's disease progression. The body could absorb a limited amount of nicotinamide at a time, requiring multiple doses through a day. To overcome such an obstacle which reduces the patient compliance, a sustained/controlled delivery system could be useful. METHOD: Nicotinamide loaded solid lipid nanoparticles (SLN) were prepared and functionalized with polysorbate 80 (S80), phosphatidylserine (PS) or phosphatidic acid (PA)...
November 1, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30382546/a-systematic-review-of-nano-formulation-of-natural-products-for-the-treatment-of-inflammatory-bowel-disease-drug-delivery-and-pharmacological-targets
#5
Yasamin Davatgaran Taghipour, Roodabeh Bahramsoltani, André M Marques, Rozita Naseri, Roja Rahimi, Pouya Haratipour, Amin Iran Panah, Mohammad Hosein Farzaei, Mohammad Abdollahi
Inflammatory bowel diseases (IBD), which is classified into Crohn's disease and ulcerative colitis, are among chronic gastrointestinal diseases with unknown pathogenesis. Diverse strategies have been applied for the treatment of this chronic disease. However, selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance. Consequently, the application and effects of natural products in the form of nanoformulation and stimuli responsive nanoparticles as a novel strategy for the treatment of IBD are discussed in this review article...
October 31, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30377988/identification-of-rate-limiting-enzymes-involved-in-paclitaxel-biosynthesis-pathway-affected-by-coronatine-and-methyl-%C3%AE-cyclodextrin-in-taxus-baccata-l-cell-suspension-cultures
#6
Kimia Kashani, Mokhtar Jalali Javaran, Mohammad Sadegh Sabet, Ahmad Moieni
BACKGROUND: Paclitaxel is a potent antitumor alkaloid widely used for the treatment of several cancer types. This valuable secondary metabolite naturally exists in the inner bark of Taxus species in very low amounts. The small-scale production of paclitaxel in Taxus cell cultures requires utilization of several elicitors. OBJECTIVE: The main objective of this work was to identify key genes that encode rate-limiting enzymes in paclitaxel biosynthesis pathway by investigating the possible relationship between paclitaxel production and a set of 13 involved genes' relative expression in Taxus baccata L...
October 30, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30374834/metal-and-bacterial-contamination-of-illicit-drugs
#7
LETTER
Jonathan Schimmel, Samaneh Nakhaee, Omid Mehrpour
No abstract text is available yet for this article.
October 29, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30361888/consistency-evaluation-between-matrix-components-ratio-and-microbiological-potency-of-tylosin-major-components
#8
Khadijeh Hamidian, Mohsen Amini, Nasrin Samadi
BACKGROUND: The aim of our research work was to investigate the relative potencies of matrix components of tylosin, a multi-component antibiotic, and establishing a quantitative relationship between content and potency of each component. METHODS: The potencies of tylosin matrix components were determined by using three bioassay methods. The content of tylosin components (tylosin A, B, C, and D) in different tylosin samples were determined by using high pressure liquid chromatography (HPLC) technique and their theoretical potencies were calculated...
October 25, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30353379/neuroprotective-antidiabetic-and-antioxidant-effect-of-hedera-nepalensis-and-lupeol-against-stz-alcl-3-induced-rats-model
#9
Waleed Javed Hashmi, Hammad Ismail, Furrukh Mehmood, Bushra Mirza
PURPOSE: This study was aimed to evaluate the effect of Hedera nepalensis crude extract (HNC) and its isolated compound lupeol on antioxidant defence system, biochemical parameters and behavioural indices of Alzheimer disease generated in diabetic rats. METHODS: To evaluate the effect of the plant extract and lupeol, symptoms of Alzheimer and diabetes were induced in rats by STZ + AlCl3 treatment. Glucose level was measured with glucometer followed by antioxidant and biochemical assessment of the treated and untreated animals...
October 23, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30242673/determination-of-synthetic-pharmaceutical-adulterants-in-herbal-weight-gain-supplements-sold-in-herb-shops-tehran-iran
#10
Niosha Saberi, Maryam Akhgari, Leila Bahmanabadi, Elham Bazmi, Zahra Mousavi
BACKGROUND: Nowadays with the growing popularity of herbal remedies across the world, large sections of population rely on herbal drug practitioners for their primary care. Therefore there is a need to ensure about the safety of herbal drugs and to detect adulteration with undeclared active pharmaceutical ingredients. Herbal drugs are used as first-line drug therapy in some instances. Unfortunately even if there are claims as to be natural, undeclared active pharmaceutical ingredients have been detected in these supplements...
September 21, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30242672/identification-and-anti-cancer-activity-in-2d-and-3d-cell-culture-evaluation-of-an-iranian-isolated-marine-microalgae-picochlorum-sp-rcc486
#11
Mohammad Haji Abolhasani, Maliheh Safavi, Mohammad Taghi Goodarzi, Seyed Mehrdad Kassaee, Mehrdad Azin
PURPOSE: Cancer disease is the second cause of death in the world. Now a days, high percentage of drugs, which are involved in treatment of cancers, have natural origin. Introduction of microalgae strains as anti-cancer drugs origin is a valuable approach for cancer therapy. METHODS: In the present study we describe the isolation, characterization, and anti-proliferative activity of a new microalga strain (Picochlorum sp. RCC486) from Iran. The cytotoxic activity of four different algal extracts including methanol, ethyl acetate, chloroform, and hexane were evaluated against MDA-MB-231, MCF-7, Hep-G2, and A-549 cell liens...
September 21, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30242671/effects-of-metformin-on-the-pi3k-akt-foxo1-pathway-in-anaplastic-thyroid-cancer-cell-lines
#12
Zahra Nozhat, Samira Mohammadi-Yeganeh, Feridoun Azizi, Maryam Zarkesh, Mehdi Hedayati
BACKGROUND: The PI3K/AKT/FOXO signaling pathway plays an important role in the survival, proliferation and apoptosis of tumor cells. The aim of the present study was to explore whether metformin could affect insulin-promoting cell growth by regulation of this pathway. MATERIAL AND METHODS: Anaplastic thyroid cancer cells were treated with 0-60 mM metformin for 24, 48 and 72 h. Cell viability, morphology, apoptosis and migration were investigated by MTT assay, microscopy observation, AnexinV-PI and the wound healing assay, respectively...
September 21, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30209760/effect-of-cinnamic-acid-and-folfox-in-diminishing-side-population-and-downregulating-cancer-stem-cell-markers-in-colon-cancer-cell-line-ht-29
#13
Sara Soltanian, Helia Riahirad, Athareh Pabarja, Elham Jafari, Behjat Kalantari Khandani
PURPOSE: There is a lot of evidence suggesting that a small subset of cancer cells resistant to conventional chemotherapy and radiotherapy and known as cancer stem cells (CSCs) is responsible for promoting metastasis and cancer relapse. Therefore, targeting and eliminating the CSCs could lead to higher survival rates and a better quality of life. In comparison with conventional chemical drugs that may not be effective against CSCs, phytochemicals are strong anti-CSCs agents. The current study examines the effect of 5-fluorouracil plus oxaliplatin (FOLFOX) as a common chemotherapy drug on colorectal cancer as well as the influence of Cinnamic acid (CINN) as a plant-derived phytochemical on colon cancer stem-like cells in HT-29 adenocarcinoma cell line...
September 12, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30209759/magnetic-delivery-of-antitumor-carboplatin-by-using-pegylated-niosomes
#14
Fereshteh Davarpanah, Aliakbar Khalili Yazdi, Mahmood Barani, Mohammad Mirzaei, Masoud Torkzadeh-Mahani
To improve the efficiency of niosomal drug delivery, here we employed two tactics. First, niosomes were magnetized using Fe3 O4 @SiO2 mangnetic nanoparticles, and second, their surface was modified by PEGylation. PEGylation was intended for increasing the bioavailability of niosomes, and magnetization was used for rendering them capable of targeting specific tissues. These PEGylated magnetic niosomes were also loaded with Carboplatin, an antitumor drug. Next, these niosomes were studied in terms of size, morphology, zeta potential, and drug entrapment efficiency...
September 12, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30209758/proliferation-and-in-vitro-wound-healing-effects-of-the-microniosomes-containing-narcissus-tazetta-l-bulb-extract-on-primary-human-fibroblasts-hdfs
#15
Maryam Rameshk, Fariba Sharififar, Mitra Mehrabani, Abbas Pardakhty, Alireza Farsinejad, Mehrnaz Mehrabani
PURPOSE: In Traditional Persian Medicine (TPM), different natural treatments have been suggested for skin damages such as Narcissus tazetta L. bulb application. New drug delivery systems such as niosomes have shown considerable increase transdermal drug delivery through stratum corneum, the main barrier against substances transport into skin. The aim of this study is preparation of niosomal formulations from N. tazetta bulb extract and evaluation of its in vitro wound healing effect. MATERIALS AND METHODS: Non-ionic surfactant vesicles (NSVs or niosomes) were prepared by film hydration method from percolated extract of N...
September 12, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30206897/pharmacokinetic-and-pharmacodynamic-studies-of-etodolac-loaded-vesicular-gels-on-rats-by-transdermal-delivery
#16
Nimmathota Madhavi, Beeravelli Sudhakar, K V N Suresh Reddy, Jayanthi Vijaya Ratna
BACKGROUND: The present study includes the development of liposomal and ethosomal gels for transdermal delivery to overcome the side effects associated with oral route. METHODS: The liposomes and ethosomes were prepared by 32 factorial design using film hydration and cold methods, respectively. Different concentrations of liposomal (ETO-LG) and ethosomal (ETO-EG) gels were prepared at 1%, 2 and 3% (w/v) using carbopol 940 NF. 1%w/v ETO-LG & ETO-EG were optimized upon rheological studies of prepared gels...
September 11, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30159764/replacing-dental-amalgam-by-mercury-free-restorative-materials-it-s-time-to-take-action
#17
LETTER
Hila Yousefi
No abstract text is available yet for this article.
September 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30159763/lipid-drug-conjugates-a-potential-nanocarrier-system-for-oral-drug-delivery-applications
#18
Subham Banerjee, Amit Kundu
Hydrophilic drugs are preferred candidates for most routes of drug administration, because of their enhanced solubility and dissolution under aqueous in vivo conditions. However, their hydrophilic nature also leads to decreased permeability across hydrophobic barriers. This is a severe limitation in situations where membrane permeability is the primary factor affecting bioavailability and efficacy of the drug. Highly impermeable cellular membranes or the tight endothelial junctions governing the blood-brain barrier are prime examples of this limitation...
September 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30159762/lawsone-loaded-niosome-and-its-antitumor-activity-in-mcf-7-breast-cancer-cell-line-a-nano-herbal-treatment-for-cancer
#19
Mahmood Barani, Mohammad Mirzaei, Masoud Torkzadeh-Mahani, Mohammad Hadi Nematollahi
Phytochemicals like Lawsone have some drawbacks that stem from their poor solubility. Low solubility in aqueous mediums results in low bioavailability, poor permeability and instability of phytochemical compounds in biological environments. The aim of this study was to design nanoniosomes containing Lawsone (Law) using non-ionic surfactants and cholesterol. Niosomes were prepared by thin film hydration method (TFH). Then, they were loaded with Henna extract (HLaw) and standard Lawsone (SLaw), and two resulted formulations were compared...
September 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30159761/in-vitro-melanogenesis-inhibition-by-fluphenazine-and-prochlorperazine-in-normal-human-melanocytes-lightly-pigmented
#20
Michał Otręba, Artur Beberok, Dorota Wrześniok, Ewa Buszman
PURPOSE: Fluphenazine and prochlorperazine as phenothiazine-class antipsychotic drugs are widely used to treat schizophrenia, however their use is associated with significant side effects such as extrapyramidal symptoms, as well as ocular and skin disorders. Our goal was to determine the effect of fluphenazine and prochlorperazine on cell viability and melanogenesis in lightly pigmented normal human melanocytes. METHODS: The viability of melanocytes was evaluated by the WST-1 colorimetric assay, while melanin content and tyrosinase activity were tested spectrophotometrically...
September 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
journal
journal
39838
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"