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Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences

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https://www.readbyqxmd.com/read/30607887/time-to-teach-basic-and-regulatory-aspects-of-art-of-prescription-writing-for-better-doctor-patient-safety-and-keeping-communication-accessible-and-straight
#1
Mohammed Imran, Chintan Doshi, Darshan Kharadi
PURPOSE: The basic and regulatory knowledge of prescription writing is essential for every medical student to evolve into a prescribing physician. Prescription becomes the most important clinical pharmacology tool and evidence of the medication access, prescription errors, prescribing errors, negligence and further litigations once released from the hands of the physicians. A questionnaire based cross-sectional survey was done to evaluate knowledge of basic and regulatory aspects of prescription writing in the light of growing violence against physicians in India...
January 3, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30607886/phage-antibody-library-screening-for-the-selection-of-novel-high-affinity-human-single-chain-variable-fragment-against-gastrin-receptor-an-in-silico-and-in-vitro-study
#2
Sepideh Jalilzadeh-Razin, Malihe Mantegi, Mohammad R Tohidkia, Yaghub Pazhang, Mohammad M Pourseif, Jaleh Barar, Yadollah Omidi
BACKGROUND: As a membrane G protein coupled receptors (GPCRs) family, gastrin/cholecystokinin-2 receptor (CCK2R) plays a key role in the initiation and development of gastric cancer. OBJECTIVES: Targeting CCK2R by immunotherapeutics such as single-chain variable fragments (scFvs) may provide an effective treatment modality against gastric cancer. Thus, the main objective of this study was to isolate scFvs specific to CCK2R. METHODS: To isolate scFvs specific to the CCK2R, we capitalized on a semi-synthetic diverse phage antibody library (PAL) and a solution-phase biopanning process...
January 3, 2019: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30565158/a-simulation-model-to-evaluate-pharmaceutical-supply-chain-costs-in-hospitals-the-case-of-a-colombian-hospital
#3
Carlos Franco
BACKGROUND: Healthcare costs is one of the most studied issue in our days because of increasing demand and the aging of population. Final costs of medicines is one of the most important issue in patient treatment and determine its real value is an important task within hospitals. Simulation models and in this case system dynamics allows to build representations of reality considering the interaction of the whole variables that affect the system where first a causal loop diagram allows to represent and identify the interaction between variables for develop a stock flow diagram to determine the final results...
December 18, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30554368/adsorption-and-in-vitro-release-study-of-curcumin-form-polyethyleneglycol-functionalized-multi-walled-carbon-nanotube-kinetic-and-isotherm-study
#4
Somayeh Koupaei Malek, Mohammad Ali Gabris, Binta Hadi Jume, Raheleh Baradaran, Madzlan Aziz, Khairil Juhanni Bt Abd Karim, Hamid Rashidi Nodeh
Polyethylene glycol functionalized with oxygenated multi-walled carbon nanotubes (O-PEG-MWCNTs) as an efficient nanomaterial for the in vitro adsorption/release of curcumin (CUR) anticancer agent. The synthesized material was morphologically characterized using scanning electron microscopy, Fourier transform infrared spectroscopy and transmission electron microscopy. In addition, the CUR adsorption process was assessed with kinetic and isotherm models fitting well with pseudo-second order and Langmuir isotherms...
December 15, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30478655/correction-to-a-systematic-review-of-nano-formulation-of-natural-products-for-the-treatment-of-inflammatory-bowel-disease-drug-delivery-and-pharmacological-targets
#5
Yasamin Davatgaran Taghipour, Roodabeh Bahramsoltani, André M Marques, Rozita Naseri, Roja Rahimi, Pouya Haratipour, Amin Iranpanah, Mohammad Hosein Farzaei, Mohammad Abdollahi
The corresponding author, Mohammad Hosein Farzaei, affiliation is Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. The correct spelling of the 7th author surname is Iranpanah.
November 26, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30460618/detecting-medical-prescriptions-suspected-of-fraud-using-an-unsupervised-data-mining-algorithm
#6
Mohammad Haddad Soleymani, Mehdi Yaseri, Farshad Farzadfar, Adel Mohammadpour, Farshad Sharifi, Mohammad Javad Kabir
Nowadays, health insurance companies face various types of fraud, like phantom billing, up-coding, and identity theft. Detecting such frauds is thus of vital importance to reduce and eliminate corresponding financial losses. We used an unsupervised data mining algorithm and implemented an outlier detection model to assist the experts in detecting medical prescriptions suspected of fraud. The implementation ran medicine code, patients' sex, and patients' age variables through three successive screening steps...
November 20, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30421278/lessons-from-one-year-experience-of-pooled-procurement-of-pharmaceuticals-exploration-of-indicators-and-assessing-pharmacies-performance
#7
Peivand Bastani, Mohammad Hadi Imanieh, Hesam Dorosti, Reza Abbasi, Seyyed Alireza Dashti, Khosro Keshavarz
BACKGROUND: Joint procurement of medicines is a way to improve access and justice in developing countries. The aim of this study is to determine local indicators for assessing the performance of joint procurement agencies and compare the indicators in those pharmacies which use centralized purchasing before and after this change. METHODS: This was a mixed method study. In the first qualitative phase, 3 expert panels were held including 20 national experts who were selected through purposeful sampling...
November 12, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30411191/anticancer-potential-of-ferula-hezarlalehzarica-y-ajani-fraction-in-raji-lymphoma-cell-line-induction-of-apoptosis-cell-cycle-arrest-and-changes-in-mitochondrial-membrane-potential
#8
Yahya Asemani, Abbas Azadmehr, Reza Hajiaghaee, Zahra Amirghofran
BACKGROUND: Cancer is a major cause of mortality. The present study evaluates the antitumor effects of Ferula hezarlalehzarica Y. Ajani fractions on various cancer cell lines, including the Raji Burkitt's lymphoma cells. METHODS: We evaluated the cytotoxic activity of various fractions of F. hezarlalehzarica against tumor cell lines by the MTT assay. Annexin V-PE/7-AAD and cell cycle analysis were assessed by flow cytometry. Expressions of genes associated with cell death and proliferation (Bax, Bcl-2, Fas, and c-Myc) were determined using real-time PCR...
November 9, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30392156/n-substituted-piperazinyl-sarafloxacin-derivatives-synthesis-and-in-vitro-antibacterial-evaluation
#9
Ali Asadipour, Mohammad Hassan Moshafi, Leila Khosravani, Setareh Moghimi, Elham Amou, Loghman Firoozpour, Ghazaleh Ilbeigi, Keivan Beiki, Ehsan Soleimani, Alireza Foroumadi
BACKGROUND: Fluoroquinolones (FQs) are compounds of major interest with broad antimicrobial activities against community and hospital-acquired infections such as respiratory tract infections (nosocomial pneumonia, chronic bronchitis and tuberculosis), skin and soft tissue infections, bone and joint infections, intra-abdominal infections and sexually transmitted diseases. This broad range of activities along with favorable pharmacokinetic and low toxicity introduced this class of compounds as important antimicrobial chemotherapy agents...
November 3, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30386982/nicotinamide-loaded-functionalized-solid-lipid-nanoparticles-improves-cognition-in-alzheimer-s-disease-animal-model-by-reducing-tau-hyperphosphorylation
#10
Molood Alsadat Vakilinezhad, Azadeh Amini, Hamid Akbari Javar, Batool Faegheh Baha'addini Beigi Zarandi, Hashem Montaseri, Rassoul Dinarvand
BACKGROUND: Nicotinamide is considered to be effective in halting the Alzheimer's disease progression. The body could absorb a limited amount of nicotinamide at a time, requiring multiple doses through a day. To overcome such an obstacle which reduces the patient compliance, a sustained/controlled delivery system could be useful. METHOD: Nicotinamide loaded solid lipid nanoparticles (SLN) were prepared and functionalized with polysorbate 80 (S80), phosphatidylserine (PS) or phosphatidic acid (PA)...
November 1, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30382546/a-systematic-review-of-nano-formulation-of-natural-products-for-the-treatment-of-inflammatory-bowel-disease-drug-delivery-and-pharmacological-targets
#11
Yasamin Davatgaran Taghipour, Roodabeh Bahramsoltani, André M Marques, Rozita Naseri, Roja Rahimi, Pouya Haratipour, Amin Iran Panah, Mohammad Hosein Farzaei, Mohammad Abdollahi
Inflammatory bowel diseases (IBD), which is classified into Crohn's disease and ulcerative colitis, are among chronic gastrointestinal diseases with unknown pathogenesis. Diverse strategies have been applied for the treatment of this chronic disease. However, selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance. Consequently, the application and effects of natural products in the form of nanoformulation and stimuli responsive nanoparticles as a novel strategy for the treatment of IBD are discussed in this review article...
October 31, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30377988/identification-of-rate-limiting-enzymes-involved-in-paclitaxel-biosynthesis-pathway-affected-by-coronatine-and-methyl-%C3%AE-cyclodextrin-in-taxus-baccata-l-cell-suspension-cultures
#12
Kimia Kashani, Mokhtar Jalali Javaran, Mohammad Sadegh Sabet, Ahmad Moieni
BACKGROUND: Paclitaxel is a potent antitumor alkaloid widely used for the treatment of several cancer types. This valuable secondary metabolite naturally exists in the inner bark of Taxus species in very low amounts. The small-scale production of paclitaxel in Taxus cell cultures requires utilization of several elicitors. OBJECTIVE: The main objective of this work was to identify key genes that encode rate-limiting enzymes in paclitaxel biosynthesis pathway by investigating the possible relationship between paclitaxel production and a set of 13 involved genes' relative expression in Taxus baccata L...
October 30, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30374834/metal-and-bacterial-contamination-of-illicit-drugs
#13
LETTER
Jonathan Schimmel, Samaneh Nakhaee, Omid Mehrpour
No abstract text is available yet for this article.
October 29, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30361888/consistency-evaluation-between-matrix-components-ratio-and-microbiological-potency-of-tylosin-major-components
#14
Khadijeh Hamidian, Mohsen Amini, Nasrin Samadi
BACKGROUND: The aim of our research work was to investigate the relative potencies of matrix components of tylosin, a multi-component antibiotic, and establishing a quantitative relationship between content and potency of each component. METHODS: The potencies of tylosin matrix components were determined by using three bioassay methods. The content of tylosin components (tylosin A, B, C, and D) in different tylosin samples were determined by using high pressure liquid chromatography (HPLC) technique and their theoretical potencies were calculated...
October 25, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30353379/neuroprotective-antidiabetic-and-antioxidant-effect-of-hedera-nepalensis-and-lupeol-against-stz-alcl-3-induced-rats-model
#15
Waleed Javed Hashmi, Hammad Ismail, Furrukh Mehmood, Bushra Mirza
PURPOSE: This study was aimed to evaluate the effect of Hedera nepalensis crude extract (HNC) and its isolated compound lupeol on antioxidant defence system, biochemical parameters and behavioural indices of Alzheimer disease generated in diabetic rats. METHODS: To evaluate the effect of the plant extract and lupeol, symptoms of Alzheimer and diabetes were induced in rats by STZ + AlCl3 treatment. Glucose level was measured with glucometer followed by antioxidant and biochemical assessment of the treated and untreated animals...
October 23, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30478656/differential-regulation-of-cd4-t-cell-subsets-by-silymarin-in-vitro-and-in-ovalbumin-immunized-mice
#16
Haideh Namdari, Maryam Izad, Farhad Rezaei, Zahra Amirghofran
CD4+ T cell subsets including regulatory T cells (Tregs), Th1 and Th17 are critical for control and development of inflammation and autoimmunity. We investigated the in vitro and in vivo effects of silymarin, a well-known herbal medicine on differentiation and function of Tregs and Th1 and Th17 responses. For in vitro study, mice splenocytes treated with 20-30 μg/ml silymarin were evaluated for gene expressions of specific transcription factors and cytokines of CD4+ T cell subsets using real-time PCR. Induction of Treg cell development in the presence of silymarin was performed on isolated naïve CD4+ T cells...
December 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30402721/new-mechanisms-of-phenytoin-in-calcium-homeostasis-competitive-inhibition-of-cd38-in-hippocampal-cells
#17
Leila Sadeghi, Reza Yekta, Gholamreza Dehghan
PURPOSE: Phenytoin is a major anticonvulsant drug that is effective to improve arrhythmia and neuropathic pain. According to early works, phenytoin affected cell membrane depolarization by sodium channel blocking, guanylyl and adenylyl cyclase suppression that cause to intracellular Na+ and Ca2+ downregulation. This study was aimed to clarify some ambiguities in pathophysiological action of phenytoin by in vitro and molecular docking analyses. METHODS: In this study intracellular free Ca2+ of primary culture of embryonic mouse hippocampus evaluated via Fura 2 as fluorescent probe...
December 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30242673/determination-of-synthetic-pharmaceutical-adulterants-in-herbal-weight-gain-supplements-sold-in-herb-shops-tehran-iran
#18
Niosha Saberi, Maryam Akhgari, Leila Bahmanabadi, Elham Bazmi, Zahra Mousavi
BACKGROUND: Nowadays with the growing popularity of herbal remedies across the world, large sections of population rely on herbal drug practitioners for their primary care. Therefore there is a need to ensure about the safety of herbal drugs and to detect adulteration with undeclared active pharmaceutical ingredients. Herbal drugs are used as first-line drug therapy in some instances. Unfortunately even if there are claims as to be natural, undeclared active pharmaceutical ingredients have been detected in these supplements...
September 21, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30242672/identification-and-anti-cancer-activity-in-2d-and-3d-cell-culture-evaluation-of-an-iranian-isolated-marine-microalgae-picochlorum-sp-rcc486
#19
Mohammad Haji Abolhasani, Maliheh Safavi, Mohammad Taghi Goodarzi, Seyed Mehrdad Kassaee, Mehrdad Azin
PURPOSE: Cancer disease is the second cause of death in the world. Now a days, high percentage of drugs, which are involved in treatment of cancers, have natural origin. Introduction of microalgae strains as anti-cancer drugs origin is a valuable approach for cancer therapy. METHODS: In the present study we describe the isolation, characterization, and anti-proliferative activity of a new microalga strain (Picochlorum sp. RCC486) from Iran. The cytotoxic activity of four different algal extracts including methanol, ethyl acetate, chloroform, and hexane were evaluated against MDA-MB-231, MCF-7, Hep-G2, and A-549 cell liens...
September 21, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/30242671/effects-of-metformin-on-the-pi3k-akt-foxo1-pathway-in-anaplastic-thyroid-cancer-cell-lines
#20
Zahra Nozhat, Samira Mohammadi-Yeganeh, Feridoun Azizi, Maryam Zarkesh, Mehdi Hedayati
BACKGROUND: The PI3K/AKT/FOXO signaling pathway plays an important role in the survival, proliferation and apoptosis of tumor cells. The aim of the present study was to explore whether metformin could affect insulin-promoting cell growth by regulation of this pathway. MATERIAL AND METHODS: Anaplastic thyroid cancer cells were treated with 0-60 mM metformin for 24, 48 and 72 h. Cell viability, morphology, apoptosis and migration were investigated by MTT assay, microscopy observation, AnexinV-PI and the wound healing assay, respectively...
September 21, 2018: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
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