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Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences

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https://www.readbyqxmd.com/read/27832818/erratum-to-opportunities-and-obstacles-to-the-development-of-nanopharmaceuticals-for-human-use
#1
Nasser Nassiri Koopaei, Mohammad Abdollahi
No abstract text is available yet for this article.
November 10, 2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27716437/effects-of-developmental-exposure-to-silver-in-ionic-and-nanoparticle-form-a-study-in-rats
#2
Mohammad Charehsaz, Karin Sørig Hougaard, Hande Sipahi, Asiye Işın Doğan Ekici, Çiğdem Kaspar, Mustafa Culha, Ülkü Ündeğer Bucurgat, Ahmet Aydin
BACKGROUND: Evaluations of silver in both nanoparticle (Ag-NPs) and ionic forms indicate some adverse effects on living organisms, but little is known about their potential for developmental toxicity. In this study, developmental toxicity of Ag-NPs (from 0.2 to 20 mg/kg/day) and ionic Ag (AgNO3, 20 mg Ag/kg/day) were investigated in rats. METHODS: Animals were dosed by gavage from gestation day 7 - 20. The day after parturition, dams and pups were sacrificed and Ag level assessed in several maternal and pup organs...
October 6, 2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27716350/opportunities-and-obstacles-to-the-development-of-nanopharmaceuticals-for-human-use
#3
Nasser Nassiri Koopaei, Mohammad Abdollahi
Pharmaceutical nanotechnology has generated breakthrough developments in improving health care and human life from its emergence. The biomaterials employed mainly aim at improving drug delivery systems, imaging and diagnostic technologies while the nanoscale materials are in widespread use in other industries such as electronics and optics. Such advancement may revolutionize the drug development and therapy with new and more efficient treatments. Although, nanotechnology assists humankind in improving its well being, it has certain limitations that entail thorough investigation by the regulatory and scientific authorities...
October 6, 2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27716340/pharmacokinetics-of-calycopterin-and-xanthmicrol-two-polymethoxylated-hydroxyflavones-with-anti-angiogenic-activities-from-dracocephalum-kotschyi-bioss
#4
Seyedeh-Somayeh Zamani, Mohsen Hossieni, Mahmoud Etebari, Pirooz Salehian, Soltan Ahmad Ebrahimi
BACKGROUND: Recently flavonoids have attracted the attention of researchers in the fight against cancer. Calycopterin and xanthomicrol, are two polymethoxylated flavonoids found in the aerial parts of Dracocephalum kotschyi Bioss.. We have recently shown that these compounds possess antiangiogenic activity and may be of value as potential anticancer agents. In order to demonstrate putative in vivo antitumor effect of these compounds we needed preliminary information on both pharmacokinetics and toxicological properties of these two agents...
October 4, 2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/26739353/two-cox-2-inhibitors-induce-apoptosis-in-human-erythroleukemia-k562cells-by-modulating-nf-%C3%AE%C2%BAb-and-fhc-pathways
#5
Shaghayegh Norouzi, Mahnaz Norouzi, Mohsen Amini, Amir Amanzadeh, Mohamad Nabiuni, Saeed Irian, Mona Salimi
BACKGROUND: Leukemia is distinguished by abnormal proliferation of leukocytes. Although there has been some progress in developing novel cancer therapies, no significant improvement was observed in the overall survival rate over the last decade. Selective cyclooxygenase-2 (COX-2) inhibitors are known to inhibit tumor growth by exerting antimetastatic and antiangiogenic effects through inhibition of COX -dependent and independent pathways. The ability of two new triaryl-oxadiazole derivatives, compounds A (3-(4-chlorophenyl) -5-(4-flurophenyl)-4-Phenyl-4,5-dihydro-1,2,4-oxadiazole) and B (3,5-bis(4-chlorophenyl)-4-Phenyl-4,5-dihydro-1,2,4-oxadiazole), to induce apoptosis in human erythroleukemia K562 cells was evaluated and the upstream mechanism was investigated...
January 7, 2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27473554/fabrication-and-biological-evaluation-of-chitosan-coated-hyaluronic-acid-docetaxel-conjugate-nanoparticles-in-cd44-cancer-cells
#6
Nazanin Shabani Ravari, Navid Goodarzi, Farhad Alvandifar, Mohsen Amini, Effat Souri, Mohammad Reza Khoshayand, Zahra Hadavand Mirzaie, Fatemeh Atyabi, Rassoul Dinarvand
BACKGROUND: Hyaluronic acid (HA) has been used for target-specific drug delivery because of strong affinity to CD44, a marker in which overexpressed in cancer cells and cancer stem cells. Conjugation of HA to the cytotoxic agents via active targeting can improve efficacy, biodistribution, and water solubility. To be able to benefit from passive targeting as well, a nanoparticulate system by counter ion using a polycation like chitosan may lead to a perfect delivery system. METHODS: Water soluble Hyaluronic acid-Docetaxel (HA-DTX) conjugate was prepared and used to formulate chitosan-coated HA-DTX nanoparticles by polyelectrolyte complex (PEC) method and optimized using Box-Behnken design...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27465859/aspirin-use-and-bleeding-volume-in-skin-cancer-patients-undergoing-surgery-a-randomized-controlled-trial
#7
LETTER
Arman Engheta, Shahryar Hadadi Abianeh, Ali Atri, Mehdi Sanatkarfar
UNLABELLED: ᅟ: We investigated the occurrence of bleeding complications in patients who underwent skin tumor surgery and compared it between Aspirin users and a placebo control group. In this double blind randomized controlled trial, 32 patients who continued taking aspirin (intervention group) and 38 patients who stopped taking Aspirin (placebo group) before surgery were compared in terms of intraoprative and postoperative bleeding problems, hematoma and local signs of coagulopathy...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27457358/erratum-to-women-only-drug-treatment-services-and-needs-in-iran-the-first-review-of-current-literature
#8
Zahra Alam-Mehrjerdi, Reza Daneshmand, Mercedeh Samiei, Roya Samadi, Mohammad Abdollahi, Kate Dolan
No abstract text is available yet for this article.
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27401785/expression-purification-and-biological-activity-assessment-of-romiplostim-biosimilar-peptibody
#9
Shima Fayaz, Pezhman Fard-Esfahani, Majid Golkar, Mojgan Allahyari, Sedigheh Sadeghi
BACKGROUND: Romiplostim is a peptibody analogue of thrombopoietin (TPO) which regulates platelet production. This molecule consists of two main parts: Peptide sequences which like wild type TPO, mimics stimulation of TPO receptor and IgG1Fc, (Peptide + Antibody = Peptibody). This drug is used in treatment of chronic Immune Thrombocytopenic Purpura (ITP). METHODS: In this project E. coli bacteria were transformed by a construct harboring peptibody fusion gene...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27342070/crocin-suppresses-multidrug-resistance-in-mrp-overexpressing-ovarian-cancer-cell-line
#10
Shadi Mahdizadeh, Gholamreza Karimi, Javad Behravan, Sepideh Arabzadeh, Hermann Lage, Fatemeh Kalalinia
BACKGROUND: Crocin, one of the main constituents of saffron extract, has numerous biological effects such as anti-cancer effects. Multidrug resistance-associated proteins 1 and 2 (MRP1 and MRP2) are important elements in the failure of cancer chemotherapy. In this study we aimed to evaluate the effects of crocin on MRP1 and MRP2 expression and function in human ovarian cancer cell line A2780 and its cisplatin-resistant derivative A2780/RCIS cells. METHODS: The cytotoxicity of crocin was assessed by the MTT assay...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27267989/comparison-between-a-serum-creatinine-and-a-cystatin-c-based-glomerular-filtration-rate-equation-in-patients-receiving-amphotericin-b
#11
Iman Karimzadeh, Hossein Khalili
Serum cystatin C (Cys C) has a number of advantages over serum creatinine in the evaluation of kidney function. Apart from Cys C level itself, several formulas have also been introduced in different clinical settings for the estimation of glomerular filtration rate (GFR) based upon serum Cys C level. The aim of the present study was to compare a serum Cys C-based equation with Cockcroft-Gault serum creatinine-based formula, both used in the calculation of GFR, in patients receiving amphotericin B. Fifty four adult patients with no history of acute or chronic kidney injury having been planned to receive conventional amphotericin B for an anticipated duration of at least 1 week for any indication were recruited...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27150961/effects-of-phloretin-on-oxidative-and-inflammatory-reaction-in-rat-model-of-cecal-ligation-and-puncture-induced-sepsis
#12
Mehdi Aliomrani, Mohammad Reza Sepand, Hamid Reza Mirzaei, Ali Reza Kazemi, Saeid Nekonam, Omid Sabzevari
BACKGROUND: Sepsis is a debilitating systemic disease and described as a severe and irregular systemic inflammatory reaction syndrome (SIRS) against infection. We employed CLP (Cecal Ligation and Puncture) model in rats to investigate anti-inflammatory and antioxidant effects of phloretin, as a natural antioxidant agent, and its protective effect on liver tissue damage caused by sepsis. METHODS: Male Wistar albino rats were randomly divided into three groups: sham group, CLP induced sepsis group and phloretin treated CLP group...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27150818/high-azithromycin-concentration-in-lungs-by-way-of-bovine-serum-albumin-microspheres-as-targeted-drug-delivery-lung-targeting-efficiency-in-albino-mice
#13
Balakeshwa Ramaiah, Sree Harsha Nagaraja, Usha Ganganahalli Kapanigowda, Prakash Rao Boggarapu, Rajarajan Subramanian
BACKGROUND: Following administration, the antibiotic travels freely through the body and also accumulates in other parts apart from the infection site. High dosage and repeated ingestion of antibiotics in the treatment of pneumonia leads to undesirable effects and inappropriate disposition of the drug. By way of targeted lung delivery, this study was intended to eliminate inappropriate azithromycin disposition and to achieve higher azithromycin concentration to treat deeper airway infections...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27142000/preliminary-investigation-of-the-effects-of-topical-mixture-of-lawsonia-inermis-l-and-ricinus-communis-l-leaves-extract-in-treatment-of-osteoarthritis-using-mia-model-in-rats
#14
Atousa Ziaei, Shamim Sahranavard, Mohammad Javad Gharagozlou, Mehrdad Faizi
BACKGROUND: Many plants have been introduced in Iranian traditional medicine for treatment of different joint problems including knee pain. Topical application of the mixture of Lawsonia inermis L. leaves (Henna) with aqueous extract of Ricinus communis L. leaves have been mentioned to have significant effects on reducing knee pain. The present study was designed to evaluate the analgesic and anti-inflammatory effects of the mixture of these two herbs in male rats. METHODS: We induced knee osteoarthritis as a model of chronic pain by intra-articular injection of mono sodium iodoacetate (MIA)...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27141958/challenges-of-access-to-medicine-and-the-responsibility-of-pharmaceutical-companies-a-legal-perspective
#15
Saeed Ahmadiani, Shekoufeh Nikfar
The right to health as a basic human right- and access to medicine as a part of it- have been a matter of attention for several decades. Also the responsibilities of different parties- particularly pharmaceutical companies- in realization of this right has been emphasized by World Health Organization. This is while many companies find no incentive for research and development of medicines related to rare diseases. Also some legal structures such as "patent agreements" clearly cause huge difficulties for access to medicine in many countries...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27117180/retraction-note-drying-of-a-plasmid-containing-formulation-chitosan-as-a-protecting-agent
#16
(no author information available yet)
No abstract text is available yet for this article.
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27068692/a-model-for-priority-setting-of-health-technology-assessment-the-experience-of-ahp-topsis-combination-approach
#17
Mohammadreza Mobinizadeh, Pouran Raeissi, Amir Ashkan Nasiripour, Alireza Olyaeemanesh, Seyed Jamaleddin Tabibi
BACKGROUND: In recent times, the use of health technologies in the diagnosis and treatment of diseases experienced considerable and accelerated growth. The goal of the present study was to describe the designated pilot MCDM (Multiple Criteria Decision Making) model for priority setting of health technology assessment in Iran. METHODS: Relevant articles were sought and retrieved from the most appropriate medical databases, including the Cochrane Library, PubMed and Scopus via three separate search strategies, using MESH and free text until March, 2015...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27001042/osmolarity-a-hidden-factor-in-nanotoxicology
#18
LETTER
Saeid Moayyedi, Omid Mashinchian, Rassoul Dinarvand
In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of long circulating nanocarriers in the blood stream on osmolarity of plasma has not been reported before. In this study, osmotic pressure developed by some commercially available nanocarriers was estimated based on Van't Hoff equation. It is noteworthy that theoretically, nanocarriers do not have any significant effect on osmolarity of plasma...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/26980217/characterization-and-pharmacological-potential-of-lactobacillus-sakei-1i1-isolated-from-fresh-water-fish-zacco-koreanus
#19
Vivek K Bajpai, Jeong-Ho Han, Gyeong-Jun Nam, Rajib Majumder, Chanseo Park, Jeongheui Lim, Woon Kee Paek, Irfan A Rather, Yong-Ha Park
BACKGROUND: There are still a large variety of microorganisms among aquatic animals which have not been explored for their pharmacological potential. Hence, present study was aimed to isolate and characterize a potent lactic acid bacterium from fresh water fish sample Zacco koreanus, and to confirm its pharmacological potential. METHODS: Isolation of lactic acid bacteria (LAB) from fresh water fish samples was done using serial dilution method. Biochemical identification and molecular characterization of selected LAB isolate 1I1, based on its potent antimicrobial efficacy, was accomplished using API kit and 16S rRNA gene sequencing analysis...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/26926657/does-pharmacist-supervised-intervention-through-pharmaceutical-care-program-influence-direct-healthcare-cost-burden-of-newly-diagnosed-diabetics-in-a-tertiary-care-teaching-hospital-in-nepal-a-non-clinical-randomised-controlled-trial-approach
#20
Dinesh Kumar Upadhyay, Mohamed Izham Mohamed Ibrahim, Pranaya Mishra, Vijay M Alurkar, Mukhtar Ansari
BACKGROUND: Cost is a vital component for people with chronic diseases as treatment is expected to be long or even lifelong in some diseases. Pharmacist contributions in decreasing the healthcare cost burden of chronic patients are not well described due to lack of sufficient evidences worldwide. In developing countries like Nepal, the estimation of direct healthcare cost burden among newly diagnosed diabetics is still a challenge for healthcare professionals, and pharmacist role in patient care is still theoretical and practically non-existent...
2016: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
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