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Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging

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https://www.readbyqxmd.com/read/29789994/performance-evaluation-of-a-semi-automated-method-for-18-f-fdg-uptake-in-abdominal-visceral-adipose-tissue
#1
Stefanie A de Boer, Daan S Spoor, Riemer H J A Slart, Douwe J Mulder, Melanie Reijrink, Ronald J H Borra, Gerbrand M Kramer, Otto S Hoekstra, Ronald Boellaard, Marcel J Greuter
PURPOSE: Severity of abdominal obesity and possibly levels of metabolic activity of abdominal visceral adipose tissue (VAT) are associated with an increased risk for cardiovascular disease (CVD). In this context, the purpose of the current study was to evaluate the reproducibility and repeatability of a semi-automated method for assessment of the metabolic activity of VAT using 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET)/x-ray computed tomography (CT)...
May 22, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29761416/bioluminescence-imaging-of-transplanted-mesenchymal-stem-cells-by-overexpression-of-hepatocyte-nuclear-factor4%C3%AE-tracking-biodistribution-and-survival
#2
Peiyi Xie, Xiaojun Hu, Dan Li, Sidong Xie, Zhiyang Zhou, Xiaochun Meng, Hong Shan
PURPOSE: The purposes of this study were to construct immortalized human bone marrow mesenchymal stem cells (UE7T-13) with overexpression of the hepatocyte nuclear factor4α (hHNF4α) and luciferase2-mKate2 dual-fusion reporter gene, further investigate their impact on treating acute liver injury (ALI) in rats, and track their biodistribution and survival by bioluminescence imaging (BLI). PROCEDURES: The hHNF4α and luciferase2-mKate2 genes were transduced by a lentiviral vector into UE7T-13 cells (named E7-hHNF4α-R cells), and expression was verified by immunofluorescence, RT-PCR, and flow cytometry...
May 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29748904/androgen-receptor-signaling-in-castration-resistant-prostate-cancer-alters-hyperpolarized-pyruvate-to-lactate-conversion-and-lactate-levels-in-vivo
#3
Niki Zacharias, Jaehyuk Lee, Sumankalai Ramachandran, Sriram Shanmugavelandy, James McHenry, Prasanta Dutta, Steven Millward, Seth Gammon, Eleni Efstathiou, Patricia Troncoso, Daniel E Frigo, David Piwnica-Worms, Christopher J Logothetis, Sankar N Maity, Mark A Titus, Pratip Bhattacharya
PURPOSE: Androgen receptor (AR) signaling affects prostate cancer (PCa) growth, metabolism, and progression. Often, PCa progresses from androgen-sensitive to castration-resistant prostate cancer (CRPC) following androgen-deprivation therapy. Clinicopathologic and genomic characterizations of CRPC tumors lead to subdividing CRPC into two subtypes: (1) AR-dependent CRPC containing dysregulation of AR signaling alterations in AR such as amplification, point mutations, and/or generation of splice variants in the AR gene; and (2) an aggressive variant PCa (AVPC) subtype that is phenotypically similar to small cell prostate cancer and is defined by chemotherapy sensitivity, gain of neuroendocrine or pro-neural marker expression, loss of AR expression, and combined alterations of PTEN, TP53, and RB1 tumor suppressors...
May 10, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29740741/zero-extra-dose-pet-delayed-imaging-with-data-driven-attenuation-correction-estimation
#4
Lifang Pang, Wentao Zhu, Yun Dong, Yang Lv, Hongcheng Shi
PURPOSE: Delayed positron emission tomography (PET) imaging may improve sensitivity and specificity in lesion detection. We proposed a PET data-driven method to estimate the attenuation map (AM) for the delayed scan without an additional x-ray computed tomography (CT). PROCEDURES: An emission-attenuation-scatter joint estimation framework was developed. Several practical issues for clinical datasets were addressed. Particularly, the unknown scatter correction was incorporated in the joint estimation algorithm...
May 8, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29736564/change-in-the-binding-of-11-c-bu99008-to-imidazoline-i-2-receptor-using-brain-pet-in-zucker-rats
#5
Kazunori Kawamura, Tomoteru Yamasaki, Yiding Zhang, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Masayuki Fujinaga, Ming-Rong Zhang
PURPOSE: The imdazoline I2 receptor (I2 R) has been found in the feeding centers of the brain, such as the hypothalamus, and certain I2 R ligands have been reported to stimulate food intake. Thus, it has been proposed that I2 R may play a role in feeding control. [11 C]BU99008 was developed as a positron emission tomography (PET) tracer for imaging of I2 R. [11 C]BU99008 displayed relatively high brain penetration and specific binding by brain PET studies in preclinical studies. Here, we evaluated a pathological condition caused by obesity related to I2 R function by quantitative PET study using [11 C]BU99008...
May 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29736563/multispectral-photoacoustic-imaging-of-tumor-protease-activity-with-a-gold-nanocage-based-activatable-probe
#6
Cheng Liu, Shiying Li, Yanjuan Gu, Huahua Xiong, Wing-Tak Wong, Lei Sun
PURPOSE: Tumor proteases have been recognized as significant regulators in the tumor microenvironment, but the current strategies for in vivo protease imaging have tended to focus on the development of a probe design rather than the investigation of a novel imaging strategy by leveraging the imaging technique and probe. Herein, it is the first report to investigate the ability of multispectral photoacoustic imaging (PAI) to estimate the distribution of protease cleavage sites inside living tumor tissue by using an activatable photoacoustic (PA) probe...
May 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29736562/evaluation-of-brain-nuclear-medicine-imaging-tracers-in-a-murine-model-of-sepsis-associated-encephalopathy
#7
Dávid Szöllősi, Nikolett Hegedűs, Dániel S Veres, Ildikó Futó, Ildikó Horváth, Noémi Kovács, Bernadett Martinecz, Ádám Dénes, Daniel Seifert, Ralf Bergmann, Ondřej Lebeda, Zoltán Varga, Zoltán Kaleta, Krisztián Szigeti, Domokos Máthé
PURPOSE: The purpose of this study was to evaluate a set of widely used nuclear medicine imaging agents as possible methods to study the early effects of systemic inflammation on the living brain in a mouse model of sepsis-associated encephalopathy (SAE). The lipopolysaccharide (LPS)-induced murine systemic inflammation model was selected as a model of SAE. PROCEDURES: C57BL/6 mice were used. A multimodal imaging protocol was carried out on each animal 4 h following the intravenous administration of LPS using the following tracers: [99m Tc][2,2-dimethyl-3-[(3E)-3-oxidoiminobutan-2-yl]azanidylpropyl]-[(3E)-3-hydroxyiminobutan-2-yl]azanide ([99m Tc]HMPAO) and ethyl-7-[125 I]iodo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate ([125 I]iomazenil) to measure brain perfusion and neuronal damage, respectively; 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) to measure cerebral glucose uptake...
May 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29736561/the-utility-of-18-f-dasa-23-for-molecular-imaging-of-prostate-cancer-with-positron-emission-tomography
#8
Corinne Beinat, Tom Haywood, Yun-Sheng Chen, Chirag B Patel, Israt S Alam, Surya Murty, Sanjiv Sam Gambhir
PURPOSE: There is a strong, unmet need for superior positron emission tomography (PET) imaging agents that are able to measure biochemical processes specific to prostate cancer. Pyruvate kinase M2 (PKM2) catalyzes the concluding step in glycolysis and is a key regulator of tumor growth and metabolism. Elevation of PKM2 expression was detected in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas, indicating that PKM2 may potentially be a marker of aggressive prostate cancer. We have recently reported the development of a PKM2-specific radiopharmaceutical [18 F]DASA-23 and herein describe its evaluation in cell culture and preclinical models of prostate cancer...
May 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29713959/performance-evaluation-of-a-dedicated-preclinical-pet-ct-system-for-the-assessment-of-mineralization-process-in-a-mouse-model-of-atherosclerosis
#9
Guillaume Rucher, Lucie Cameliere, Jihene Fendri, Ahmed Abbas, Kevin Dupont, Said Kamel, Nicolas Delcroix, Axel Dupont, Ludovic Berger, Alain Manrique
PURPOSE: The purpose of this study was to assess the impact of positron emission tomography/X-ray computed tomography (PET/CT) acquisition and reconstruction parameters on the assessment of mineralization process in a mouse model of atherosclerosis. PROCEDURES: All experiments were performed on a dedicated preclinical PET/CT system. CT was evaluated using five acquisition configurations using both a tungsten wire phantom for in-plane resolution assessment and a bar pattern phantom for cross-plane resolution...
April 30, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29713958/noise-induced-variability-of-immuno-pet-with-zirconium-89-labeled-antibodies-an-analysis-based-on-count-reduced-clinical-images
#10
Yvonne W S Jauw, Dennis F Heijtel, Josée M Zijlstra, Otto S Hoekstra, Henrica C W de Vet, Danielle J Vugts, Henk M Verheul, Ronald Boellaard, Sonja Zweegman, Guus A M S van Dongen, C Willemien Menke-van der Houven van Oordt, Adriaan A Lammertsma, Marc C Huisman
PURPOSE: Positron emission tomography (PET) with Zirconium-89 (Zr-89)-labeled antibodies can be used for in vivo quantification of antibody uptake. Knowledge about measurement variability is required to ensure correct interpretation. However, no clinical studies have been reported on measurement variability of Zr-89 immuno-PET. As variability due to low signal-to-noise is part of the total measurement variability, the aim of this study was to assess noise-induced variability of Zr-89 -immuno-PET using count-reduced clinical images...
April 30, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29687324/imaging-vegf-receptors-and-%C3%AE-v-%C3%AE-3-integrins-in-a-mouse-hindlimb-ischemia-model-of-peripheral-arterial-disease
#11
Yared Tekabe, Qing Li, Geping Zhang, Jordan Johnson, Ann Marie Schmidt, Marina Backer, Joseph Backer, Lynne L Johnson
PURPOSE: To compare targeted imaging of vascular endothelial growth factor (VEGF) receptors vs. αv β3 integrins in a mouse hindlimb ischemia model of peripheral artery disease. PROCEDURES: Male wild-type (WT) C57BL/6 mice (8- to 10-week old) (n = 24) underwent left femoral artery ligation. The right leg served as control. Five days later, mice were injected with either VEGF receptor targeting [99m Tc]DOTA-PEG-scVEGF ([99m Tc]scV) (n = 8) or with αv β3 -targeting tracer [99m Tc]HYNIC-cycloRGD ([99m Tc]RGD) (n = 8) and underwent single photon emission computed tomography (SPECT) x-ray computed tomography imaging...
April 23, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29687323/investigation-of-cis-4-18-f-fluoro-d-proline-uptake-in-human-brain-tumors-after-multimodal-treatment
#12
Antoine Verger, Gabriele Stoffels, Norbert Galldiks, Philipp Lohmann, Antje Willuweit, Bernd Neumaier, Stefanie Geisler, Karl-Josef Langen
PURPOSE: Cis-4-[18 F]fluoro-D-proline (D-cis-[18 F]FPro) has been shown to pass the intact blood-brain barrier and to accumulate in areas of secondary neurodegeneration and necrosis in the rat brain while uptake in experimental brain tumors is low. This pilot study explores the uptake behavior of D-cis-[18 F]FPro in human brain tumors after multimodal treatment. PROCEDURES: In a prospective study, 27 patients with suspected recurrent brain tumor after treatment with surgery, radiotherapy, and/or chemotherapy (SRC) were investigated by dynamic positron emission tomography (PET) using D-cis-[18 F]FPro (22 high-grade gliomas, one unspecified glioma, and 4 metastases)...
April 23, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29687322/optimization-of-a-labeling-and-kit-preparation-method-for-ga-68-labeled-dotatate-using-cation-exchange-resin-purified-ga-68-eluates-obtained-from-a-tin-dioxide-68-ge-68-ga-generator
#13
Deidré Prince, Daniel Rossouw, Sietske Rubow
PURPOSE: The aim of this study was to optimize a radiolabeling method using cationic processed Ga-68 eluates from a SnO2 -based 68 Ge/68 Ga generator, followed by the development of DOTA-Tyr3 -Thre8 -octreotide (DOTATATE) kits. PROCEDURES: Diluted generator eluates were adsorbed on a SCX resin and desorbed with acidified 5 M NaCl solution. Optimized labeling conditions were determined by variation of pH, using 35 μg DOTATATE and sodium acetate buffer. DOTATATE kits were developed based on optimized radiolabeling conditions, were labeled, and evaluated...
April 23, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29679299/impact-of-computer-aided-ct-and-pet-analysis-on-non-invasive-t-staging-in-patients-with-lung-cancer-and-atelectasis
#14
Paul Flechsig, Ramin Rastgoo, Clemens Kratochwil, Ole Martin, Tim Holland-Letz, Alexander Harms, Hans-Ulrich Kauczor, Uwe Haberkorn, Frederik L Giesel
PURPOSE: Tumor delineation within an atelectasis in lung cancer patients is not always accurate. When T staging is done by integrated 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG)-positron emission tomography (PET)/X-ray computer tomography (CT), tumors of neuroendocrine differentiation and slowly growing tumors can present with reduced FDG uptake, thus aggravating an exact T staging. In order to further exhaust information derived from [18 F]FDG-PET/CT, we evaluated the impact of CT density and maximum standardized uptake value (SUVmax) for the classification of different tumor subtypes within a surrounding atelectasis, as well as possible cutoff values for the differentiation between the primary tumor and atelectatic lung tissue...
April 20, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29671177/tri-modal-in-vivo-imaging-of-pancreatic-islets-transplanted-subcutaneously-in-mice
#15
Sayuan Liang, Karim Louchami, Bryan Holvoet, Rein Verbeke, Christophe M Deroose, Bella Manshian, Stefaan J Soenen, Ine Lentacker, Uwe Himmelreich
PURPOSE: Transplantation of pancreatic islets (PIs) is a promising therapeutic approach for type 1 diabetes. The main obstacle for this strategy is that the outcome of islet engraftment depends on the engraftment site. It was our aim to develop a strategy for using non-invasive imaging techniques to assess the location and fate of transplanted PIs longitudinally in vivo. PROCEDURES: In order to overcome the limitations of individual imaging techniques and cross-validate findings by different modalities, we have combined fluorine magnetic resonance imaging (F-19 MRI), fluorescence imaging (FLI), and bioluminescent imaging (BLI) for studying subcutaneously transplanted PIs and beta cell-like cells (INS-1E cell line) in vivo...
April 18, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29651576/fluorescence-molecular-imaging-and-tomography-of-matrix-metalloproteinase-activatable-near-infrared-fluorescence-probe-and-image-guided-orthotopic-glioma-resection
#16
Li Li, Yang Du, Xinjian Chen, Jie Tian
PURPOSE: Malignant gliomas are major causes of cancer-related mortality and morbidity. Traditional surgery usually leads to incomplete resection of gliomas resulting in the high incidence of tumor recurrence. Advanced medical imaging technology, such as fluorescence imaging-guided surgery, combined with tumor-specific imaging probes allows the identification of tumor margins and improved surgery. However, there are two pressing issues that need to be addressed: first, few fluorescence imaging probes can specifically target gliomas; second, fluorescence molecular imaging (FMI) cannot get the in-depth information of deep-seated gliomas; both of which affect the complete removal of the gliomas...
April 12, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29637401/pet-imaging-reveals-brain-metabolic-changes-in-adolescent-rats-following-chronic-escalating-morphine-administration
#17
Qing Chen, Haifeng Hou, Jin Feng, Xiaohui Zhang, Yao Chen, Jing Wang, Jianfeng Ji, Xiao He, Hao Wu, Hong Zhang
PURPOSE: Non-medical use of prescription opioids, especially among adolescents, has been substantially increased in recent years. However, the neuromechanism remains largely unexplored. In the present study, we aimed to investigate the brain metabolic changes in adolescent rats following chronic escalating morphine administration using positron emission tomography (PET). PROCEDURES: 2-Deoxy-2-[18 F]Fluoro-D-glucose ([18 F]FDG) microPET imaging was performed, and statistical parametric mapping (SPM) was used for image analysis...
April 10, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29633108/a-simple-ultrasound-based-classification-algorithm-allows-differentiation-of-benign-from-malignant-breast-lesions-by-using-only-quantitative-parameters
#18
Panagiotis Kapetas, Ramona Woitek, Paola Clauser, Maria Bernathova, Katja Pinker, Thomas H Helbich, Pascal A Baltzer
PURPOSE: We hypothesized that different quantitative ultrasound (US) parameters may be used as complementary diagnostic criteria and aimed to develop a simple classification algorithm to distinguish benign from malignant breast lesions and aid in the decision to perform biopsy or not. PROCEDURES: One hundred twenty-four patients, each with one biopsy-proven, sonographically evident breast lesion, were included in this prospective, IRB-approved study. Each lesion was examined with B-mode US, Color/Power Doppler US and elastography (Acoustic Radiation Force Impulse-ARFI)...
April 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29623510/to-explore-a-representative-hypoxic-parameter-to-predict-the-treatment-response-and-prognosis-obtained-by-18-f-fmiso-pet-in-patients-with-non-small-cell-lung-cancer
#19
Li Li, Yuchun Wei, Yong Huang, Qingxi Yu, Wenju Liu, Shuqiang Zhao, Jinsong Zheng, Hong Lu, Jinming Yu, Shuanghu Yuan
PURPOSE: To explore a representative hypoxic parameter to predict the treatment response and prognosis for [18 F]fluoromisonidazole ([18 F]FMISO) positron emission tomography (PET)/X-ray computed tomography (CT) in patients with non-small cell lung cancer (NSCLC). PROCEDURES: Twenty-nine patients with NSCLC underwent FMISO-PET scans before chemoradiotherapy (CRT). The maximum standard uptake values (SUVmax) in the tumor, normal lung, aortic arch, and vertical ridge muscle were measured, and the tumor-to-lung (T/L) ratios, tumor-to-blood (T/B) ratios, ands tumor-to-muscle (T/M) ratios were calculated and analyzed...
April 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29560588/pet-imaging-analysis-of-vitamin-b-1-kinetics-with-11-c-thiamine-and-its-derivative-11-c-thiamine-tetrahydrofurfuryl-disulfide-in-rats
#20
Satoshi Nozaki, Aya Mawatari, Yuka Nakatani, Emi Hayashinaka, Yasuhiro Wada, Yukihiro Nomura, Takahito Kitayoshi, Kouji Akimoto, Shinji Ninomiya, Hisashi Doi, Yasuyoshi Watanabe
PURPOSE: Thiamine is an essential component of glucose metabolism and energy production. The disulfide derivative, thiamine tetrahydrofurfuryl disulfide (TTFD), is better absorbed than readily-available water-soluble thiamine salts because it does not require the rate-limiting transport system required for thiamine absorption. However, the detailed pharmacokinetics of thiamine and TTFD under normal and pathological conditions have not yet been clarified. C-11-labeled thiamine and TTFD were recently synthesized by our group...
March 20, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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