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Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging

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https://www.readbyqxmd.com/read/30014345/pre-therapy-somatostatin-receptor-based-heterogeneity-predicts-overall-survival-in-pancreatic-neuroendocrine-tumor-patients-undergoing-peptide-receptor-radionuclide-therapy
#1
Rudolf A Werner, Harun Ilhan, Sebastian Lehner, László Papp, Norbert Zsótér, Imke Schatka, Dirk O Muegge, Mehrbod S Javadi, Takahiro Higuchi, Andreas K Buck, Peter Bartenstein, Frank Bengel, Markus Essler, Constantin Lapa, Ralph A Bundschuh
PURPOSE: Early identification of aggressive disease could improve decision support in pancreatic neuroendocrine tumor (pNET) patients prior to peptide receptor radionuclide therapy (PRRT). The prognostic value of intratumoral textural features (TF) determined by baseline somatostatin receptor (SSTR)-positron emission tomography (PET) before PRRT was analyzed. PROCEDURES: Thirty-one patients with G1/G2 pNET were enrolled (G2, n = 23/31). Prior to PRRT with [177 Lu]DOTATATE (mean, 3...
July 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30003453/the-complexity-and-fractal-geometry-of-nuclear-medicine-images
#2
Fabio Grizzi, Angelo Castello, Dorina Qehajaj, Carlo Russo, Egesta Lopci
Irregularity in shape and behavior is the main feature of every anatomical system, including human organs, tissues, cells, and sub-cellular entities. It has been shown that this property cannot be quantified by means of the classical Euclidean geometry, which is only able to describe regular geometrical objects. In contrast, fractal geometry has been widely applied in several scientific fields. This rapid growth has also produced substantial insights in the biomedical imaging. Consequently, particular attention has been given to the identification of pathognomonic patterns of "shape" in anatomical entities and their changes from natural to pathological states...
July 12, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29998399/spect-ct-imaging-of-mycobacterium-tuberculosis-infection-with-125-i-anti-c3d-mab
#3
Catherine A Foss, Liudmila Kulik, Alvaro A Ordonez, Sanjay K Jain, V Michael Holers, Joshua M Thurman, Martin G Pomper
PURPOSE: Diagnosis and therapeutic monitoring of chronic bacterial infection requires methods to detect and localize sites of infection accurately. Complement C3 activation fragments are generated and covalently bound to selective bacterial pathogens during the immune response and can serve as biomarkers of ongoing bacterial infection. We have developed several probes for detecting tissue-bound C3 deposits, including a monoclonal antibody (mAb 3d29) that recognizes the tissue-bound terminal processing fragments iC3b and C3d but does not recognize native circulating C3 or tissue-bound C3b...
July 11, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29987621/quantitative-intensity-harmonization-of-dopamine-transporter-spect-images-using-gamma-mixture-models
#4
Alberto Llera, Ismael Huertas, Pablo Mir, Christian F Beckmann
PURPOSE: Differences in site, device, and/or settings may cause large variations in the intensity profile of dopamine transporter (DAT) single-photon emission computed tomography (SPECT) images. However, the current standard to evaluate these images, the striatal binding ratio (SBR), does not efficiently account for this heterogeneity and the assessment can be unequivalent across distinct acquisition pipelines. In this work, we present a voxel-based automated approach to intensity normalize such type of data that improves on cross-session interpretation...
July 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29987620/linked-hexokinase-and-glucose-6-phosphatase-activities-reflect-grade-of-ovarian-malignancy
#5
Birgitte Brinkmann Olsen, Albert Gjedde, Mie Holm Vilstrup, Iben Birgit Gade Johnsen, Gudrun Neumann, Drew Avedis Torigian, Abass Alavi, Poul Flemming Høilund-Carlsen
PURPOSE: Malignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities. PROCEDURES: Twenty-nine women with suspected ovarian cancer had positron emission tomography (PET) prior to surgery. From fresh-frozen tissue, we determined the activities of HK and G6Pase, and from the PET images, we determined the tumor maximum standardized uptake value (SUVmax) of 2-deoxy-2-[18 F]fluoro-D-glucose...
July 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29987619/test-retest-stability-of-cerebral-2-deoxy-2-18-f-fluoro-d-glucose-18-f-fdg-positron-emission-tomography-pet-in-male-and-female-rats
#6
Jürgen W A Sijbesma, Aren van Waarde, David Vállez García, Hendrikus H Boersma, Riemer H J A Slart, Rudi A J O Dierckx, Janine Doorduin
PURPOSE: An important issue in rodent imaging is the question whether a mixed population of male and female animals can be used rather than animals of a single sex. For this reason, the present study examined the test-retest stability of positron emission tomography (PET) with 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) in male rats and female rats at different phases of the estrous cycle. PROCEDURES: Long-Evans rats (age 1 year) were divided into three groups: (1) males (n = 6), (2) females in metestrous (low estrogen levels, n = 9), and (3) females in proestrous (high estrogen levels, n = 7)...
July 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29987618/evaluation-of-glucose-uptake-and-uncoupling-protein-1-activity-in-adipose-tissue-of-diabetic-mice-upon-%C3%AE-adrenergic-stimulation
#7
Narumi Kubo, Mio Kawahara, Yuko Okamatsu-Ogura, Yosuke Miyazaki, Ryuto Otsuka, Kazuki Fukuchi
PURPOSE: Regulation of metabolic activity in adipose tissue is of great concern for treating obesity. This study aimed to evaluate the adrenergic regulation of glucose uptake and the thermogenic program in adipose tissues in mouse models of both type 1 and 2 diabetes mellitus (DM). PROCEDURES: Male mice were treated with streptozotocin to induce type 1 (T1) DM, and obese ob/ob mice were used for the type 2 (T2) DM model. After selective β3 -adrenoreceptor stimulation by CL 316,243 (CL) treatment, 2-deoxy-D-[14 C]glucose ([14 C]DG) was administered to DM and corresponding control mice...
July 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29987617/how-long-of-a-dynamic-3-deoxy-3-18-f-fluorothymidine-18-f-flt-pet-acquisition-is-needed-for-robust-kinetic-analysis-in-breast-cancer
#8
Jun Zhang, Xiaoli Liu, Michelle I Knopp, Bhuvaneswari Ramaswamy, Michael V Knopp
PURPOSE: To quantitatively evaluate the minimally required scanning time of 3'-deoxy-3'-[18 F]fluorothymidine ([18 F]FLT) positron emission tomography (PET) dynamic acquisition for accurate kinetic assessment of the proliferation in breast cancer tumors. PROCEDURES: Within a therapeutic intervention trial, 26 breast tumors of 8 breast cancer patients were analyzed from 30-min dynamic [18 F]FLT-PET acquisitions. PET/CT was acquired on a Gemini TF 64 system (Philips Healthcare) and reconstructed into 26 frames (8 × 15 s, 6 × 30 s, 5 × 1 min, 5 × 2 min, and 2 × 5 min)...
July 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29987616/differentiation-of-malignant-and-benign-head-and-neck-tumors-with-amide-proton-transfer-weighted-mr-imaging
#9
Lu Yu, Chunmei Li, Xiaojie Luo, Jinyuan Zhou, Chen Zhang, Yi Zhang, Min Chen
PURPOSE: To prospectively evaluate the feasibility and capability of amide proton transfer-weighted (APTw) imaging for the characterization of head and neck tumors. PROCEDURES: Twenty-nine consecutive patients with suspected head and neck tumors were enrolled in this study and underwent APTw magnetic resonance imaging (MRI) on a 3.0-T MRI scanner. The patients were divided into malignant (n = 16) and benign (n = 13) groups, based on pathological results...
July 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29987615/imaging-pulmonary-foreign-body-reaction-using-125-i-iodo-dpa-713-spect-ct-in-mice
#10
Julian Sanchez-Bautista, Catherine A Foss, Alvaro A Ordonez, Mariah H Klunk, Sanjay K Jain
PURPOSE: Foreign body reactions elicit granulomatous inflammation composed of reactive macrophages. We hypothesized that [125 I]iodo-DPA-713 single-photon emission computed tomography (SPECT), a low-molecular-weight pyrazolopyrimidine ligand selectively trapped by phagocytes, could be used to detect foreign body reactions in a murine model. PROCEDURES: C57BL/6 mice intratracheally inoculated with dextran beads, which developed foreign body lesions, were imaged after injection of [125 I]iodo-DPA-713 or DPA-713-IRDye800CW using SPECT and optical imaging, respectively...
July 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29968183/x-ray-based-3d-virtual-histology-adding-the-next-dimension-to-histological-analysis
#11
REVIEW
J Albers, S Pacilé, M A Markus, M Wiart, G Vande Velde, G Tromba, C Dullin
Histology and immunohistochemistry of thin tissue sections have been the standard diagnostic procedure in many diseases for decades. This method is highly specific for particular tissue regions or cells, but mechanical sectioning of the specimens is required, which destroys the sample in the process and can lead to non-uniform tissue deformations. In addition, regions of interest cannot be located beforehand and the analysis is intrinsically two-dimensional. Micro X-ray computed tomography (μCT) on the other hand can provide 3D images at high resolution and allows for quantification of tissue structures, as well as the localization of small regions of interest...
July 2, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29968182/effects-of-a-ketogenic-diet-on-18-f-fdg-pet-imaging-in-a-mouse-model-of-lung-cancer
#12
Lorena Cussó, Mónica Musteanu, Francisca Mulero, Mariano Barbacid, Manuel Desco
PURPOSE: Myocardial uptake can hamper visualization of lung tumors, atherosclerotic plaques, and inflammatory diseases in 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) studies because it leads to spillover in adjacent structures. Several preparatory pre-imaging protocols (including dietary restrictions and drugs) have been proposed to decrease physiological [18 F]FDG uptake by the heart, although their effect on tumor glucose metabolism remains largely unknown. The objective of this study was to assess the effects of a ketogenic diet (as an alternative protocol to fasting) on tumor glucose metabolism assessed by [18 F]FDG positron emission tomography (PET) in a mouse model of lung cancer...
July 2, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29956119/quantitative-analysis-of-heterogeneous-18-f-fdg-static-suv-vs-patlak-ki-whole-body-pet-imaging-using-different-segmentation-methods-a-simulation-study
#13
Mingzan Zhuang, Nicolas A Karakatsanis, Rudi A J O Dierckx, Habib Zaidi
PURPOSE: Whole-body (WB) dynamic positron emission tomography (PET) enables imaging of highly quantitative physiological uptake parameters beyond the standardized uptake value (SUV). We present a novel dynamic WB anthropomorphic PET simulation framework to assess the potential of 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) net uptake rate constant (Ki) imaging in characterizing tumor heterogeneity. PROCEDURES: Validated heterogeneous [18 F]FDG tumor kinetics were modeled within the XCAT phantom (ground truth)...
June 28, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29956118/near-infrared-spatially-resolved-spectroscopy-as-an-indirect-technique-to-assess-brown-adipose-tissue-in-young-women
#14
Francisco M Acosta, Jörn Berchem, Borja Martinez-Tellez, Guillermo Sanchez-Delgado, Juan M A Alcantara, Lourdes Ortiz-Alvarez, Takafumi Hamaoka, Jonatan R Ruiz
PURPOSE: Near-infrared spectroscopy (NIRS) has recently been proposed as an indirect technique to assess brown adipose tissue (BAT) in young men. NIRS arises as a novel technique to avoid the limitations of the "gold-standard" 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]DG) positron emission tomography combined with X-ray computed tomography (PET/CT). The aim of this study was to examine the association between near-infrared spatially resolved spectroscopy (NIRSRS ) parameters and BAT volume and activity estimated by [18 F]DG-PET/CT in 18 young healthy women...
June 28, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29951847/in-vivo-mapping-and-quantification-of-creatine-using-chemical-exchange-saturation-transfer-imaging-in-rat-models-of-epileptic-seizure
#15
Dong-Hoon Lee, Do-Wan Lee, Jae-Im Kwon, Chul-Woong Woo, Sang-Tae Kim, Jin Seong Lee, Choong Gon Choi, Kyung Won Kim, Jeong Kon Kim, Dong-Cheol Woo
PURPOSE: To evaluate signal changes in the hippocampus of epileptic seizure rat models, based on quantified creatine chemical exchange saturation transfer (CrCEST) signals. PROCEDURES: CEST data and 1 H magnetic resonance spectroscopy (1 H MRS) data were obtained for the two imaging groups: control (CTRL) and epileptic seizure-induced (ES; via kainic acid [KA] injection) groups. CrCEST signals in the hippocampal regions were quantitatively evaluated; correlations between CrCEST signals and phosphocreatine (PCr) and total creatine (tCr; PCr + Cr) concentrations, derived from the analysis of 1 H MRS data, were investigated as a function of time changes (before KA injection, 3 and 5 h after KA injection)...
June 27, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29942990/in-vivo-evaluation-of-magnetic-targeting-in-mice-colon-tumors-with-ultra-magnetic-liposomes-monitored-by-mri
#16
Caroline J Thébault, Grégory Ramniceanu, Aude Michel, Claire Beauvineau, Christian Girard, Johanne Seguin, Nathalie Mignet, Christine Ménager, Bich-Thuy Doan
PURPOSE: The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic liposomes (UML) into CT26 murine colon tumor by magnetic resonance imaging (MRI). PROCEDURES: Dynamic susceptibility contrast MRI was applied to assess the bloodstream circulation time...
June 25, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29942989/influence-of-multidrug-resistance-associated-proteins-on-the-excretion-of-the-abcc1-imaging-probe-6-bromo-7-11-c-methylpurine-in-mice
#17
Viktoria Zoufal, Severin Mairinger, Markus Krohn, Thomas Wanek, Thomas Filip, Michael Sauberer, Johann Stanek, Alexander Traxl, John D Schuetz, Claudia Kuntner, Jens Pahnke, Oliver Langer
PURPOSE: Multidrug resistance-associated proteins (MRPs) mediate the hepatobiliary and renal excretion of many drugs and drug conjugates. The positron emission tomography (PET) tracer 6-bromo-7-[11 C]methylpurine is rapidly converted in tissues by glutathione-S-transferases into its glutathione conjugate, and has been used to measure the activity of Abcc1 in the brain and the lungs of mice. Aim of this work was to investigate if the activity of MRPs in excretory organs can be measured with 6-bromo-7-[11 C]methylpurine...
June 25, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29942988/fluorescence-guidance-in-surgical-oncology-challenges-opportunities-and-translation
#18
REVIEW
Madeline T Olson, Quan P Ly, Aaron M Mohs
Surgical resection continues to function as the primary treatment option for most solid tumors. However, the detection of cancerous tissue remains predominantly subjective and reliant on the expertise of the surgeon. Surgery that is guided by fluorescence imaging has shown clinical relevance as a new approach to detecting the primary tumor, tumor margins, and metastatic lymph nodes. It is a technique to reduce recurrence and increase the possibility of a curative resection. While significant progress has been made in developing this emerging technology as a tool to assist the surgeon, further improvements are still necessary...
June 25, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29931433/associations-between-18-f-fdg-pet-and-complex-histopathological-parameters-including-tumor-cell-count-and-expression-of-ki-67-egfr-vegf-hif-1%C3%AE-and-p53-in-head-and-neck-squamous-cell-carcinoma
#19
Alexey Surov, Hans Jonas Meyer, Anne-Kathrin Höhn, Karsten Winter, Osama Sabri, Sandra Purz
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is one of common cancers worldwide. Positron emission tomography (PET) with 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) is increasingly used for diagnosing and staging, as well as for monitoring of treatment of HNSCC. PET parameters like maximum and mean standard uptake values (SUVmax , SUVmean ) can predict the behavior of HNSCC. The purpose of this study was to analyze possible associations between these PET parameters and clinically relevant histopathological features in patients with HNSCC...
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29931432/detection-of-sentinel-lymph-nodes-with-near-infrared-imaging-in-malignancies
#20
REVIEW
Huan-Cheng Zeng, Jia-Lin Hu, Jing-Wen Bai, Guo-Jun Zhang
Optical molecular imaging, a highly sensitive and noninvasive technique which is simple to operate, inexpensive, and has the real-time capability, is increasingly being used in the diagnosis and treatment of carcinomas. The near-infrared fluorescence dye indocyanine green (ICG) is widely used in optical imaging for the dynamic detection of sentinel lymph nodes (SLNs) in real time improving the detection rate and accuracy. ICG has the advantages of low scattering in tissue absorbance, low auto-fluorescence, and high signal-to-background ratio...
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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