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Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging

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https://www.readbyqxmd.com/read/30406513/spatial-concordance-of-tumor-proliferation-and-accelerated-repopulation-from-pathologic-images-to-3-18-f-fluoro-3-deoxythymidine-pet-images-a-basic-study-guided-for-pet-based-radiotherapy-dose-painting
#1
Chengming Li, Xiaoli Zhang, Linlin Pang, Yong Huang, Yongsheng Gao, Xindong Sun, Jinming Yu, Xue Meng
PURPOSE: To assess tumor cell proliferation and repopulation during fractionated radiotherapy and investigate the spatial concordance of cell proliferation and repopulation according to the uptake of 3'-[18 F]fluoro-3'-deoxythymidine ([18 F]FLT). PROCEDURES: Mice bearing A549 xenograft tumors were assigned to five irradiated groups, including 3 fraction (f)/6 days (d), 6f/12d, 9f/18d, 12f/24d, and 18f/36d with 2 Gy/f irradiations performed every other day and one non-irradiated group...
November 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30406512/impact-of-tumor-burden-on-quantitative-68-ga-dotatoc-biodistribution
#2
Rudolf A Werner, Heribert Hänscheid, Jeffrey P Leal, Mehrbod S Javadi, Takahiro Higuchi, Martin A Lodge, Andreas K Buck, Martin G Pomper, Constantin Lapa, Steven P Rowe
PURPOSE: As has been previously reported, the somatostatin receptor (SSTR) imaging agent [68 Ga]-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotate ([68 Ga]DOTATATE) demonstrates lower uptake in normal organs in patients with a high neuroendocrine tumor (NET) burden. Given the higher SSTR affinity of [68 Ga] DOTATATE, we aimed to quantitatively investigate the biodistribution of [68 Ga]-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-d-Phe(1)-Tyr(3)-octreotide ([68 Ga]DOTATOC) to determine a potential correlation between uptake in normal organs and NET burden...
November 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30397859/a-pilot-study-of-texture-analysis-of-primary-tumor-18-f-fdg-uptake-to-predict-recurrence-in-surgically-treated-patients-with-non-small-cell-lung-cancer
#3
Masatoyo Nakajo, Megumi Jinguji, Tetsuya Shinaji, Masaya Aoki, Atsushi Tani, Yoshiaki Nakabeppu, Masayuki Nakajo, Masami Sato, Takashi Yoshiura
PURPOSE: To examine whether the heterogeneous texture parameters in primary tumor can predict prognosis of patients with non-small cell lung cancer (NSCLC) received surgery after 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT). PROCEDURE: This retrospective study included 55 patients with NSCLC who underwent [18 F]FDG-PET/CT before surgery from January 2011 and December 2015. SUV-related (SUVmax and SUVmean), volumetric (metabolic tumor volume [SUV ≥ 2...
November 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30387020/characterization-of-brown-adipose-tissue-in-a-diabetic-mouse-model-with-spiral-volumetric-optoacoustic-tomography
#4
Avihai Ron, Xosé Luís Deán-Ben, Josephine Reber, Vasilis Ntziachristos, Daniel Razansky
PURPOSE: Diabetes is associated with a deterioration of the microvasculature in brown adipose tissue (BAT) and with a decrease in its metabolic activity. Multispectral optoacoustic tomography has been recently proposed as a new tool capable of differentiating healthy and diabetic BAT by observing hemoglobin gradients and microvasculature density in cross-sectional (2D) views. We report on the use of spiral volumetric optoacoustic tomography (SVOT) for an improved characterization of BAT...
November 1, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30377939/development-of-a-fluorinated-analogue-of-erlotinib-for-pet-imaging-of-egfr-mutation-positive-nsclc
#5
Ofer Shamni, Hilbert Grievink, Batel Itamar, Eyal Mishani, Galith Abourbeh
PURPOSE: Positron emission tomography (PET) using [11 C]erlotinib identifies non-small cell lung carcinoma (NSCLC) tumors with activating mutations in the epidermal growth factor receptor (EGFRm ). The short half-life of C-11, however, limits its clinical utility to centers with a nearby cyclotron. We therefore developed a F-18-labeled analogue of erlotinib for imaging EGFRm NSCLC. PROCEDURES: 6-O-Fluoroethylerlotinib (6-O-FEE) was synthesized and its anti-proliferative activity was tested using human NSCLC cell lines...
October 30, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30361791/predicting-glioblastoma-response-to-bevacizumab-through-mri-biomarkers-of-the-tumor-microenvironment
#6
Andreas Stadlbauer, Karl Roessler, Max Zimmermann, Michael Buchfelder, Andrea Kleindienst, Arnd Doerfler, Gertraud Heinz, Stefan Oberndorfer
PURPOSE: Glioblastoma (GB) is one of the most vascularized of all solid tumors and, therefore, represents an attractive target for antiangiogenic therapies. Many lesions, however, quickly develop escape mechanisms associated with changes in the tumor microenvironment (TME) resulting in rapid treatment failure. To prevent patients from adverse effects of ineffective therapy, there is a strong need to better predict and monitor antiangiogenic treatment response. PROCEDURES: We utilized a novel physiological magnetic resonance imaging (MRI) method combining the visualization of oxygen metabolism and neovascularization for classification of five different TME compartments: necrosis, hypoxia with/without neovascularization, oxidative phosphorylation, and aerobic glycolysis...
October 25, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30357568/-18-f-fe-ots964-a-small-molecule-targeting-topk-for-in-vivo-pet-imaging-in-a-glioblastoma-xenograft-model
#7
Giacomo Pirovano, Sheryl Roberts, Christian Brand, Patrick L Donabedian, Christian Mason, Paula Demétrio de Souza, Geoff S Higgins, Thomas Reiner
PURPOSE: Lymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) imaging allowing more accurate patient identification, stratification, and disease monitoring. PROCEDURES: [18 F]FE-OTS964 was produced starting from OTS964, a preclinical drug which specifically binds to TOPK, and using a two-step procedure with [18 F]fluoroethyl p-toluenesulfonate as a prosthetic group...
October 24, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30338432/spect-imaging-of-treatment-related-tumor-necrosis-using-technetium-99m-labeled-rhein
#8
Jiajia Liang, Qi Luo, Dongjian Zhang, Qiaomei Jin, Lichao Liu, Wei Liu, Meng Gao, Jian Zhang, Zhiqi Yin
PURPOSE: Noninvasive imaging of treatment-induced necrosis is important to distinguish early responders from patients resistant to the treatment plan, enabling the tailored-made therapeutic intervention. The purpose of this study was to explore the feasibility of [99m Tc]EDDA-HYNIC-2C-rhein for early assessment of tumor response to treatment. PROCEDURES: In vitro necrosis avidity of [99m Tc]EDDA-HYNIC-2C-rhein was evaluated in human lung cancer A549 cells treated with hyperthermia...
October 18, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30324461/correction-to-a-phase-2-study-of-16%C3%AE-18f-fluoro-17%C3%AE-estradiol-positron-emission-tomography-fes-pet-as-a-marker-of-hormone-sensitivity-in-metastatic-breast-cancer-mbc
#9
Lanell M Peterson, Brenda F Kurland, Erin K Schubert, Jeanne M Link, V K Gadi, Jennifer M Specht, Janet F Eary, Peggy Porter, Lalitha K Shankar, David A Mankoff, Hannah M Linden
Two data points from Table 1. (continued) were published in error. The corrected data in Table 1. (continued) are shown, in italic, below.
October 15, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30306318/evaluation-of-the-novel-pet-tracer-11-c-hach242-for-imaging-the-glun2b-nmda-receptor-in-non-human-primates
#10
Jasper van der Aart, Maqsood Yaqub, Esther J M Kooijman, Jaco Bakker, Jan A M Langermans, Robert C Schuit, Mark B M Hofman, Johannes A M Christiaans, Adriaan A Lammertsma, Albert D Windhorst, Bart N M van Berckel
PURPOSE: There are currently no positron emission tomography (PET) radiotracers for the GluN2B (NR2B) binding sites of brain N-methyl-D-aspartate (NMDA) receptors. In rats, the GluN2B antagonist Ro25-6981 reduced the binding of N-((5-(4-fluoro-2-[11 C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamin ([11 C]HACH242). This paper reports the evaluation of [11 C]HACH242 PET in non-human primates at baseline and following administration of the GluN2B negative allosteric modulator radiprodil...
October 10, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30284155/histogram-analysis-parameters-derived-from-conventional-t1-and-t2-weighted-images-can-predict-different-histopathological-features-including-expression-of-ki67-egfr-vegf-hif-1%C3%AE-and-p53-and-cell-count-in-head-and-neck-squamous-cell-carcinoma
#11
Hans Jonas Meyer, Leonard Leifels, Gordian Hamerla, Anne Kathrin Höhn, Alexey Surov
PURPOSE: To analyze associations between histogram analysis parameters derived from conventional magnetic resonance imaging (MRI) and different histopathological features in head and neck squamous cell carcinoma (HNSCC). PROCEDURES: Thirty-four patients with histologically proven primary HNSCC were prospectively acquired. Histogram analysis was derived from pre-contrast T1-weighted (T1w) and T2-weighted (T2w) images. In all cases, expression of HIF-1α, VEGF, EGFR, p53, Ki67, and p16 as well as tumor cell count was analyzed...
October 3, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30280292/monitoring-the-progression-of-chronic-liver-damage-in-rats-using-18-f-pbr06
#12
Shuo Huang, Chao Li, Jun Guo, Linlin Zhang, Shuqi Wu, Hui Wang, Sheng Liang
PURPOSE: Accurate and rapid assessment of liver condition is the key to therapy for hepatitis patients. This study aim is to evaluate the peripheral benzodiazepine receptor (PBR) radioligand [18 F]N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline ([18 F]PBR06) as a positron emission tomography (PET) imaging tracer of chronic liver damage in a rat model. PROCEDURES: A rat model of liver damage was made by bile duct ligation (BDL), which initiates a complex cascade of pathological events that leads to cholestasis and inflammation, eventually resulting in a severe fibrotic and severe hepatocyte injury...
October 2, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30250991/whole-body-pet-imaging-with-a-norepinephrine-transporter-probe-4-18-f-fluorobenzylguanidine-biodistribution-and-radiation-dosimetry
#13
Stephen J Lokitz, Sudha Garg, Rachid Nazih, Pradeep K Garg
PURPOSE: 4-[18 F]Fluorobenzylguanidine ([18 F]PFBG) is a positron emission tomography (PET) probe for non-invasive targeting of the norepinephrine transporter. The aim of this study was to assess uptake and distribution characteristics of this PET probe. PROCEDURES: Three cynomolgus monkeys were injected with 269 ± 51 MBq (7.3 ± 1.4 mCi) of [18 F]PFBG and 21 whole body PET scans were acquired over 165 min. s around organs to generate time-activity curves...
September 24, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30250989/does-measurement-of-first-order-and-heterogeneity-parameters-improve-response-assessment-of-bone-metastases-in-breast-cancer-compared-to-suv-max-in-18-f-fluoride-and-18-f-fdg-pet
#14
Gurdip K Azad, Francois Cousin, Musib Siddique, Benjamin Taylor, Vicky Goh, Gary J R Cook
PURPOSE: To establish whether first-order statistical features from [18 F]fluoride and 2-deoxy-2-[18 F] fluoro-D-glucose ([18 F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) demonstrate incremental value in skeletal metastasis response assessment compared with maximum standardised uptake value (SUVmax ). PROCEDURES: Sixteen patients starting endocrine treatment for de novo or progressive breast cancer bone metastases were prospectively recruited to undergo [18 F]fluoride and [18 F]FDG PET/CT scans before and 8 weeks after treatment...
September 24, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30225761/prognostic-value-of-early-evaluation-of-left-ventricular-dyssynchrony-after-myocardial-infarction
#15
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Takafumi Yamase, Norihito Akatani, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Dispersion in the contraction of the normally coordinate ventricular system, referred to as left ventricular (LV) dyssynchrony, is constantly observed at different grades of severity after myocardial infarction (MI). We aimed to investigate the prognostic value of early dyssynchrony in adverse cardiac events after MI in a rat model using the quantified gated single photon emission tomography (SPECT; QGS) software. PROCEDURES: After thoracotomy, the left coronary arteries of 16 rats were occluded and reperfused...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30225760/correlation-of-tumor-perfusion-between-carbon-13-imaging-with-hyperpolarized-pyruvate-and-dynamic-susceptibility-contrast-mri-in-pre-clinical-model-of-glioblastoma
#16
Ilwoo Park, Janine M Lupo, Sarah J Nelson
PURPOSE: The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13 C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM). PROCEDURES: C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-13 C]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30225759/adenine-nucleotide-translocase-2-as-an-enzyme-related-to-18-f-fdg-accumulation-in-various-cancers
#17
Chul-Hee Lee, Mi Jeong Kim, Hwan Hee Lee, Jin Chul Paeng, Young Joo Park, So Won Oh, Young Jun Chai, Young A Kim, Gi Jeong Cheon, Keon Wook Kang, Hyewon Youn, June-Key Chung
PURPOSE: Although glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) are known as major proteins involved in the molecular mechanisms for accumulating 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) in cancer cells, sometimes, [18 F] FDG accumulation cannot be explained by the expression of these two proteins. We investigated the involvement of adenine nucleotide translocase 2 (ANT2), which catalyzes ADP/ATP exchange at the mitochondrial inner membrane, in [18 F] FDG accumulation. PROCEDURES: ANT2 expression was evaluated in various cancer cell lines and human cancer tissues (microarrays) using western blot and immunohistochemical (IHC) staining, respectively...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30225758/pharmacokinetic-modeling-of-targeted-ultrasound-contrast-agents-for-quantitative-assessment-of-anti-angiogenic-therapy-a-longitudinal-case-control-study-in-colon-cancer
#18
Simona Turco, Ahmed El Kaffas, Jianhua Zhou, Amelie M Lutz, Hessel Wijkstra, Jürgen K Willmann, Massimo Mischi
PURPOSE: To evaluate quantitative and semi-quantitative ultrasound molecular imaging (USMI) for antiangiogenic therapy monitoring in human colon cancer xenografts in mice. PROCEDURES: Colon cancer was established in 17 mice by injection of LS174T (Nr  = 9) or CT26 (Nn  = 8) cancer cells to simulate clinical responders and non-responders, respectively. Antiangiogenic treatment (bevacizumab; Nrt  = Nnt  = 5) or control treatment (saline; Nrc  = 4, Nnc  = 3) was administered at days 0, 3, and 7...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30218390/paradigms-in-fluorescence-molecular-imaging-maximizing-measurement-of-biological-changes-in-disease-therapeutic-efficacy-and-toxicology-safety
#19
Jeffrey D Peterson
Fluorescence molecular imaging (MI) is an important concept in preclinical research that focuses on the visualization of cellular and biological function in a non-invasive fashion to better understand in vivo disease processes and treatment effects. MI differs fundamentally from traditional preclinical imaging strategies in that it generally relies on reporter probes specific for particular targets or pathways that can be used to reveal biological changes in situ, at the site(s) of disease. In contrast, the more established imaging modalities, like magnetic resonance imaging, X-ray, micro X-ray computed tomography, and ultrasound, historically have relied primarily on late-stage anatomical or physiologic changes...
September 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30218389/predictive-value-of-18-f-ml-10-pet-ct-in-early-response-evaluation-of-combination-radiotherapy-with-cetuximab-on-nasopharyngeal-carcinoma
#20
Bingxin Gu, Shuai Liu, Yuyun Sun, Jianping Zhang, Yongping Zhang, Xiaoping Xu, Huiyu Yuan, Mingwei Wang, Yingjian Zhang, Zhongyi Yang
PURPOSE: Apoptosis may be an indication of success therapy, and precise detection of apoptosis can provide instructional suggestions in the therapy management of malignant tumors. PROCEDURES: We used CNE-1 cell lines for in vitro experiments, and colony formation assay, CCK-8 assay, cell apoptosis analysis, and western blotting were performed. For in vivo experiments, subcutaneous xenotransplanted tumor models of CNE-1 in nude mice were established. Then, small animal positron emission tomography/X-ray computed tomography (PET/CT) images were acquired by tail intravenous injection of 2-(5-[18 F]fluoropentyl)-2-methyl-malonic acid ([18 F]ML-10) or 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) before and 24 h and 48 h after treatment...
September 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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