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Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging

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https://www.readbyqxmd.com/read/30225761/prognostic-value-of-early-evaluation-of-left-ventricular-dyssynchrony-after-myocardial-infarction
#1
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Takafumi Yamase, Norihito Akatani, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Dispersion in the contraction of the normally coordinate ventricular system, referred to as left ventricular (LV) dyssynchrony, is constantly observed at different grades of severity after myocardial infarction (MI). We aimed to investigate the prognostic value of early dyssynchrony in adverse cardiac events after MI in a rat model using the quantified gated single photon emission tomography (SPECT; QGS) software. PROCEDURES: After thoracotomy, the left coronary arteries of 16 rats were occluded and reperfused...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30225760/correlation-of-tumor-perfusion-between-carbon-13-imaging-with-hyperpolarized-pyruvate-and-dynamic-susceptibility-contrast-mri-in-pre-clinical-model-of-glioblastoma
#2
Ilwoo Park, Janine M Lupo, Sarah J Nelson
PURPOSE: The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13 C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM). PROCEDURES: C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-13 C]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30225759/adenine-nucleotide-translocase-2-as-an-enzyme-related-to-18-f-fdg-accumulation-in-various-cancers
#3
Chul-Hee Lee, Mi Jeong Kim, Hwan Hee Lee, Jin Chul Paeng, Young Joo Park, So Won Oh, Young Jun Chai, Young A Kim, Gi Jeong Cheon, Keon Wook Kang, Hyewon Youn, June-Key Chung
PURPOSE: Although glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) are known as major proteins involved in the molecular mechanisms for accumulating 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) in cancer cells, sometimes, [18 F] FDG accumulation cannot be explained by the expression of these two proteins. We investigated the involvement of adenine nucleotide translocase 2 (ANT2), which catalyzes ADP/ATP exchange at the mitochondrial inner membrane, in [18 F] FDG accumulation. PROCEDURES: ANT2 expression was evaluated in various cancer cell lines and human cancer tissues (microarrays) using western blot and immunohistochemical (IHC) staining, respectively...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30225758/pharmacokinetic-modeling-of-targeted-ultrasound-contrast-agents-for-quantitative-assessment-of-anti-angiogenic-therapy-a-longitudinal-case-control-study-in-colon-cancer
#4
Simona Turco, Ahmed El Kaffas, Jianhua Zhou, Amelie M Lutz, Hessel Wijkstra, Jürgen K Willmann, Massimo Mischi
PURPOSE: To evaluate quantitative and semi-quantitative ultrasound molecular imaging (USMI) for antiangiogenic therapy monitoring in human colon cancer xenografts in mice. PROCEDURES: Colon cancer was established in 17 mice by injection of LS174T (Nr  = 9) or CT26 (Nn  = 8) cancer cells to simulate clinical responders and non-responders, respectively. Antiangiogenic treatment (bevacizumab; Nrt  = Nnt  = 5) or control treatment (saline; Nrc  = 4, Nnc  = 3) was administered at days 0, 3, and 7...
September 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30218390/paradigms-in-fluorescence-molecular-imaging-maximizing-measurement-of-biological-changes-in-disease-therapeutic-efficacy-and-toxicology-safety
#5
Jeffrey D Peterson
Fluorescence molecular imaging (MI) is an important concept in preclinical research that focuses on the visualization of cellular and biological function in a non-invasive fashion to better understand in vivo disease processes and treatment effects. MI differs fundamentally from traditional preclinical imaging strategies in that it generally relies on reporter probes specific for particular targets or pathways that can be used to reveal biological changes in situ, at the site(s) of disease. In contrast, the more established imaging modalities, like magnetic resonance imaging, X-ray, micro X-ray computed tomography, and ultrasound, historically have relied primarily on late-stage anatomical or physiologic changes...
September 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30218389/predictive-value-of-18-f-ml-10-pet-ct-in-early-response-evaluation-of-combination-radiotherapy-with-cetuximab-on-nasopharyngeal-carcinoma
#6
Bingxin Gu, Shuai Liu, Yuyun Sun, Jianping Zhang, Yongping Zhang, Xiaoping Xu, Huiyu Yuan, Mingwei Wang, Yingjian Zhang, Zhongyi Yang
PURPOSE: Apoptosis may be an indication of success therapy, and precise detection of apoptosis can provide instructional suggestions in the therapy management of malignant tumors. PROCEDURES: We used CNE-1 cell lines for in vitro experiments, and colony formation assay, CCK-8 assay, cell apoptosis analysis, and western blotting were performed. For in vivo experiments, subcutaneous xenotransplanted tumor models of CNE-1 in nude mice were established. Then, small animal positron emission tomography/X-ray computed tomography (PET/CT) images were acquired by tail intravenous injection of 2-(5-[18 F]fluoropentyl)-2-methyl-malonic acid ([18 F]ML-10) or 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) before and 24 h and 48 h after treatment...
September 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30218388/inconsistent-detection-of-sites-of-metastatic-non-clear-cell-renal-cell-carcinoma-with-psma-targeted-18-f-dcfpyl-pet-ct
#7
Yafu Yin, Scott P Campbell, Mark C Markowski, Philip M Pierorazio, Martin G Pomper, Mohamad E Allaf, Steven P Rowe, Michael A Gorin
PURPOSE: To investigate the utility of prostate-specific membrane antigen (PSMA)-targeted [18 F]DCFPyL positron emission tomography (PET)/X-ray computed tomography (CT) imaging for the detection of sites of disease in patients with metastatic non-clear cell renal cell carcinoma (RCC). PROCEDURES: Eight patients with metastatic non-clear cell RCC underwent imaging with PSMA-targeted [18 F]DCFPyL PET/CT. Imaged RCC histologic subtypes included papillary RCC (n = 3), chromophobe RCC (n = 2), unclassified RCC (n = 2), and Xp11 translocation RCC (n = 1)...
September 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30215174/-68-ga-psma-pet-ct-improves-initial-staging-and-management-plan-of-patients-with-high-risk-prostate-cancer
#8
Nader Hirmas, Akram Al-Ibraheem, Ken Herrmann, Abedalatif Alsharif, Haider Muhsin, Jamal Khader, Ali Al-Daghmin, Samer Salah
PURPOSE: In this retrospective study, we compared the diagnostic value of 68 Gallium prostate-specific membrane antigen positron emission tomography computed tomography ([68 Ga]PSMA PET/CT) in primary staging of patients with high-risk prostate cancer (PCa), in comparison to CT, magnetic resonance imaging (MRI), and bone scans, and we explored its overall impact on patients' management plan. PROCEDURES: Patients with pathological confirmation of PCa with high-risk disease were included in this study...
September 13, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30194566/ferumoxytol-can-be-used-for-quantitative-magnetic-particle-imaging-of-transplanted-stem-cells
#9
Hossein Nejadnik, Prachi Pandit, Olga Lenkov, Arian Pourmehdi Lahiji, Ketan Yerneni, Heike E Daldrup-Link
PURPOSE: To evaluate, if clinically translatable ferumoxytol nanoparticles can be used for in vivo detection and quantification of stem cell transplants with magnetic particle imaging (MPI). PROCEDURES: Mesenchymal stem cells (MSCs) were labeled with ferumoxytol or ferucarbotran and underwent MPI, magnetic resonance imaging (MRI), Prussian blue staining, and inductively coupled plasma (ICP) spectrometry. Unlabeled, ferumoxytol, and ferucarbotran-labeled MSCs were implanted in calvarial defects of eight mice and underwent MPI, MRI, and histopathology...
September 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30187233/association-of-tumor-18-f-fdg-activity-and-diffusion-restriction-with-clinical-outcomes-of-rhabdomyosarcomas
#10
Arian Pourmehdi Lahiji, Tatianie Jackson, Hossein Nejadnik, Rie von Eyben, Daniel Rubin, Sheri L Spunt, Andrew Quon, Heike Daldrup-Link
PURPOSE: To evaluate whether the extent of restricted diffusion and 2-deoxy-2-[18 F] fluoro-D-glucose ([18 F]FDG) uptake of pediatric rhabdomyosarcomas (RMS) on positron emission tomography (PET)/magnetic resonance (MR) images provides prognostic information. PROCEDURE: In a retrospective, IRB-approved study, we evaluated [18 F]FDG PET/CT and diffusion-weighted (DW) MR imaging studies of 21 children and adolescents (age 1-20 years) with RMS of the head and neck...
September 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30187232/spatial-inhomogeneity-of-cardiac-norepinephrine-transport-protein-and-meta-123-i-iodobenzylguanidine-uptake-in-swine-myocardial-tissue
#11
Claudia Kusmic, Assuero Giorgetti, Cristina Barsanti, Silvia Burchielli, Debora Petroni, Annette Kusch, Dario Genovesi, Luca Menichetti, Paolo Marzullo
PURPOSE: The aim of the present study was to evaluate the expression of the cardiac norepinephrine transporter (NET) in the left ventricle (LV) of healthy pigs and its relationship with regional meta-[123 I]iodobenzylguanidine ([123 I]MIBG) myocardial uptake. PROCEDURES: Experiments were performed on animals injected with [123 I]MIBG and acquired 2 h later using an ultrafast CZT gamma camera to assess the regional myocardial uptake. After image acquisition, animals were euthanized; the heart was quickly excised and underwent to an ex vivo single photon emission tomography (SPECT) imaging...
September 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30167995/a-trimodal-imaging-platform-for-tracking-viable-transplanted-pancreatic-islets-in-vivo-f-19-mr-fluorescence-and-bioluminescence-imaging
#12
A Gálisová, V Herynek, E Swider, E Sticová, A Pátiková, L Kosinová, J Kříž, M Hájek, M Srinivas, D Jirák
PURPOSE: Combining specific and quantitative F-19 magnetic resonance imaging (MRI) with sensitive and convenient optical imaging provides complementary information about the distribution and viability of transplanted pancreatic islet grafts. In this study, pancreatic islets (PIs) were labeled with positively charged multimodal nanoparticles based on poly(lactic-co-glycolic acid) (PLGA-NPs) with encapsulated perfluoro-15-crown-5-ether and the near-infrared fluorescent dye indocyanine green...
August 30, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30167994/apoptotic-pet-imaging-of-rat-pulmonary-fibrosis-with-small-molecule-radiotracer
#13
Ying Xiong, Dahong Nie, Shaoyu Liu, Hui Ma, Shu Su, Aixia Sun, Jing Zhao, Zhanwen Zhang, Xianhong Xiang, Ganghua Tang
PURPOSE: The purpose of this study was to assess the potential utility of small-molecule apoptotic radiotracer, 2-(5-[18 F]fluoropentyl)-2-methyl malonic acid ([18 F]ML-10), for positron emission tomography (PET)/computed tomography (CT) monitoring the progression of pulmonary fibrosis in a rat model. PROCEDURES: Male Sprague-Dawley rats were used to establish a rat model of pulmonary fibrosis by means of bleomycin (BLM) administration; control rats received saline (n = 12 per group)...
August 30, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30167993/mass-spectrometry-imaging-and-integration-with-other-imaging-modalities-for-greater-molecular-understanding-of-biological-tissues
#14
REVIEW
Tiffany Porta Siegel, Gregory Hamm, Josephine Bunch, Jo Cappell, John S Fletcher, Kristina Schwamborn
Over the last two decades, mass spectrometry imaging (MSI) has been increasingly employed to investigate the spatial distribution of a wide variety of molecules in complex biological samples. MSI has demonstrated its potential in numerous applications from drug discovery, disease state evaluation through proteomic and/or metabolomic studies. Significant technological and methodological advancements have addressed natural limitations of the techniques, i.e., increased spatial resolution, increased detection sensitivity especially for large molecules, higher throughput analysis and data management...
August 30, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30151646/optical-redox-imaging-of-lonidamine-treatment-response-of-melanoma-cells-and-xenografts
#15
He N Xu, Min Feng, Kavindra Nath, David Nelson, Jeff Roman, Huaqing Zhao, Zhenwu Lin, Jerry Glickson, Lin Z Li
PURPOSE: Fluorescence of co-enzyme reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavoproteins (Fp) provides a sensitive measure of the mitochondrial redox state and cellular metabolism. By imaging NADH and Fp, we investigated the utility of optical redox imaging (ORI) to monitor cellular metabolism and detect early metabolic response to cancer drugs. PROCEDURES: We performed ORI of human melanoma DB-1 cells in culture and DB-1 mouse xenografts to detect the redox response to lonidamine (LND) treatment...
August 27, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30120644/metabolic-and-molecular-imaging-with-hyperpolarised-tracers
#16
Jason Graham Skinner, Luca Menichetti, Alessandra Flori, Anna Dost, Andreas Benjamin Schmidt, Markus Plaumann, Ferdia Aiden Gallagher, Jan-Bernd Hövener
Since reaching the clinic, magnetic resonance imaging (MRI) has become an irreplaceable radiological tool because of the macroscopic information it provides across almost all organs and soft tissues within the human body, all without the need for ionising radiation. The sensitivity of MR, however, is too low to take full advantage of the rich chemical information contained in the MR signal. Hyperpolarisation techniques have recently emerged as methods to overcome the sensitivity limitations by enhancing the MR signal by many orders of magnitude compared to the thermal equilibrium, enabling a new class of metabolic and molecular X-nuclei based MR tracers capable of reporting on metabolic processes at the cellular level...
August 17, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30112727/site-specific-labeling-of-f-18-proteins-using-a-supplemented-cell-free-protein-synthesis-system-and-o-2-18-f-fluoroethyl-l-tyrosine-18-f-fet-her2-affibody-molecule
#17
Ai Yanai, Ryuichi Harada, Ren Iwata, Takeo Yoshikawa, Yoichi Ishikawa, Shozo Furumoto, Takanori Ishida, Kazuhiko Yanai
PURPOSE: Although a preparation method for F-18-labeled proteins that used a cell-free translation system and 4-[18 F]fluoro-L-proline instead of L-proline has been reported, its introduction depends on amino acid sequences of target proteins. The purpose of the study was to propose site-specific labeling method of F-18 by using cell-free translation systems supplemented with an engineered orthogonal aminoacyl-tRNA synthetase derived from Methanocaldococcus jannaschii (pCNF-RS)/suppressor tRNA (tRNACUA opt ) pair, O-2-[18 F]fluoroethyl-L-tyrosine ([18 F]FET), and template DNA inserted with an amber codon...
August 15, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30109540/correction-to-pre-therapy-somatostatin-receptor-based-heterogeneity-predicts-overall-survival-in-pancreatic-neuroendocrine-tumor-patients-undergoing-peptide-receptor-radionuclide-therapy
#18
Rudolf A Werner, Harun Ilhan, Sebastian Lehner, László Papp, Norbert Zsótér, Imke Schatka, Dirk O Muegge, Mehrbod S Javadi, Takahiro Higuchi, Andreas K Buck, Peter Bartenstein, Frank Bengel, Markus Essler, Constantin Lapa, Ralph A Bundschuh
The article "Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy," was originally published electronically on the publisher's internet portal without open access.
August 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30105521/combined-early-and-late-68-ga-psma-hbed-cc-pet-scans-improve-lesion-detectability-in-biochemical-recurrence-of-prostate-cancer-with-low-psa-levels
#19
M Hohberg, C Kobe, P Täger, J Hammes, M Schmidt, F Dietlein, M Wild, A Heidenreich, A Drzezga, M Dietlein
PURPOSE: Our aim was to evaluate the benefit of early (1 h post-injection (p.i.)) and late (3 h p.i.) [68 Ga]PSMA-HBED-CC positron emission tomography (PET)/x-ray computed tomography (CT) imaging for detection of biochemical recurrence (BCR) of prostate cancer (PCa). PROCEDURES: Seventy patients with BCR of the PCa and prostate-specific antigen (PSA) levels of less than 2.0 μg/l were subjected to [68 Ga]PSMA-HBED-CC PET (mean injected activity 180 MBq). While early imaging contained whole body scans, late imaging was confined to the pelvis and the lower abdomen...
August 13, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30094653/sparse-detector-configuration-in-sipm-digital-photon-counting-pet-a-feasibility-study
#20
Jun Zhang, Michelle I Knopp, Michael V Knopp
PURPOSE: To investigate the minimum number of SiPM detectors required for solid-state digital photon counting (DPC) oncologic whole-body 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT). PROCEDURES: A DPC PET/CT (Vereos, Philips) with 23,040 1-to-1 crystal-to-detector couplings was utilized. [18 F]FDG PET/CT of a uniformity phantom and 10 oncology patients selected by block randomization from a large clinical trial were included (457 ± 38 MBq, 64 ± 22 min p...
August 9, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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