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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/28496147/combination-products-modernizing-the-regulatory-paradigm
#1
Nina L Hunter, Rachel E Sherman
New opportunities to develop innovative - and often complex - products that combine drugs, devices and/or biological components are rapidly emerging, raising questions about how such products should be regulated. Here, we discuss the ongoing efforts of the FDA to develop a modern, transparent, flexible and consistent science-based regulatory approach for combination products.
May 12, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28496146/the-antifungal-pipeline-a-reality-check
#2
REVIEW
John R Perfect
Invasive fungal infections continue to appear in record numbers as the immunocompromised population of the world increases, owing partially to the increased number of individuals who are infected with HIV and partially to the successful treatment of serious underlying diseases. The effectiveness of current antifungal therapies - polyenes, flucytosine, azoles and echinocandins (as monotherapies or in combinations for prophylaxis, or as empiric, pre-emptive or specific therapies) - in the management of these infections has plateaued...
May 12, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28496145/market-watch-trends-in-pharmaceutical-company-r-d-spending-2005-2015
#3
Richa Dixit, Frank S David
No abstract text is available yet for this article.
May 12, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28473729/broad-spectrum-agents-for-flaviviral-infections-dengue-zika-and-beyond
#4
REVIEW
Veaceslav Boldescu, Mira A M Behnam, Nikos Vasilakis, Christian D Klein
Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis...
May 5, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28473728/market-watch-landscape-for-medical-countermeasure-development
#5
Christopher Milne, Zachary Peter Smith, Ranjana Chakravarthy
No abstract text is available yet for this article.
May 5, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28450744/bridging-the-translational-innovation-gap-through-good-biomarker-practice
#6
Alain J van Gool, Florence Bietrix, Eric Caldenhoven, Kurt Zatloukal, Andreas Scherer, Jan-Eric Litton, Gerrit Meijer, Niklas Blomberg, Andy Smith, Barend Mons, Jaap Heringa, Wim-Jan Koot, Martin J Smit, Marian Hajduch, Ton Rijnders, Anton Ussi
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28450743/implications-of-cancer-evolution-for-drug-development
#7
Samra Turajlic, Charles Swanton
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28450742/aptamers-as-targeted-therapeutics-current-potential-and-challenges
#8
Jiehua Zhou, John Rossi
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417986/trial-watch-trends-in-clinical-trial-design-complexity
#9
Kenneth A Getz, Rafael A Campo
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28337021/different-drugs-for-bad-bugs-antivirulence-strategies-in-the-age-of-antibiotic-resistance
#10
REVIEW
Seth W Dickey, Gordon Y C Cheung, Michael Otto
The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens are outpacing the development of new antibiotics, but antivirulence agents provide an alternative. These agents can circumvent antibiotic resistance by disarming pathogens of virulence factors that facilitate human disease while leaving bacterial growth pathways - the target of traditional antibiotics - intact. Either as stand-alone medications or together with antibiotics, these drugs are intended to treat bacterial infections in a largely pathogen-specific manner...
March 24, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28337020/delivery-technologies-for-genome-editing
#11
REVIEW
Hao Yin, Kevin J Kauffman, Daniel G Anderson
With the recent development of CRISPR technology, it is becoming increasingly easy to engineer the genome. Genome-editing systems based on CRISPR, as well as transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs), are becoming valuable tools for biomedical research, drug discovery and development, and even gene therapy. However, for each of these systems to effectively enter cells of interest and perform their function, efficient and safe delivery technologies are needed. This Review discusses the principles of biomacromolecule delivery and gene editing, examines recent advances and challenges in non-viral and viral delivery methods, and highlights the status of related clinical trials...
March 24, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28303025/targeting-glutamate-signalling-in-depression-progress-and-prospects
#12
REVIEW
James W Murrough, Chadi G Abdallah, Sanjay J Mathew
Major depressive disorder (MDD) is severely disabling, and current treatments have limited efficacy. The glutamate N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine was recently repurposed as a rapidly acting antidepressant, catalysing the vigorous investigation of glutamate-signalling modulators as novel therapeutic agents for depressive disorders. In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants...
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28303024/lessons-from-immuno-oncology-a-new-era-for-cancer-nanomedicine
#13
Wen Jiang, Hengfeng Yuan, Charles K Chan, Christina A von Roemeling, Zuoqin Yan, Irving L Weissman, Betty Y S Kim
Despite a decade of intensive preclinical research, the translation of cancer nanomedicine to the clinic has been slow. Here, we discuss how recent lessons learned from the successes with immuno-oncology therapies could be applied to cancer nanomedicine and how this may help to overcome some of the key technical challenges in this field.
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28303023/market-watch-upcoming-market-catalysts-in-q2-2017
#14
Eric Ho
No abstract text is available yet for this article.
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28280261/non-kinase-targets-of-protein-kinase-inhibitors
#15
REVIEW
Lenka Munoz
Kinome-wide profiling platforms have comprehensively identified the relevant kinases that are targeted by numerous protein kinase inhibitors. However, recent projects have begun to discover non-kinase targets of kinase inhibitors. These non-kinase targets can contribute to the desired or undesired activities of inhibitors, or act as silent bystanders. As a full awareness of a drug's mechanism of action is crucial for the interpretation of results and for successful preclinical and clinical drug development, these discoveries highlight the importance of understanding the pharmacology of kinase inhibitors beyond the kinome...
March 10, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28280259/patent-watch-patent-insight-into-polymer-free-drug-eluting-stents
#16
Vadim Demidov, Daniel Currie, Justin Wen
No abstract text is available yet for this article.
March 10, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28232724/regulatory-watch-from-big-data-to-smart-data-fda-s-informed-initiative
#17
Sean Khozin, Geoffrey Kim, Richard Pazdur
No abstract text is available yet for this article.
February 24, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28428616/cancer-belt-and-braces-for-bcr-abl
#18
Megan Cully
No abstract text is available yet for this article.
May 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28428615/metabolic-disease-protein-tyrosine-phosphatase-inhibitor-reverses-diabetes
#19
Sarah Crunkhorn
No abstract text is available yet for this article.
May 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417990/g-protein-coupled-receptors-novel-probe-for-mrgprx2
#20
Crunkhorn Sarah
No abstract text is available yet for this article.
May 2017: Nature Reviews. Drug Discovery
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