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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/28428616/cancer-belt-and-braces-for-bcr-abl
#1
Megan Cully
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28428615/metabolic-disease-protein-tyrosine-phosphatase-inhibitor-reverses-diabetes
#2
Sarah Crunkhorn
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417990/g-protein-coupled-receptors-novel-probe-for-mrgprx2
#3
Crunkhorn Sarah
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417989/antibiotics-reversing-resistance
#4
Crunkhorn Sarah
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417988/analgesia-designing-out-opioid-side-effects
#5
M Teresa Villanueva
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417987/cancer-identifying-synergistic-drug-combinations
#6
Crunkhorn Sarah
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417986/trial-watch-trends-in-clinical-trial-design-complexity
#7
Kenneth A Getz, Rafael A Campo
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417985/viral-infections-targeting-host-kinases
#8
Crunkhorn Sarah
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28417984/an-audience-with-jay-bradner
#9
Asher Mullard
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28360426/bracing-for-the-biosimilar-wave
#10
Asher Mullard
No abstract text is available yet for this article.
March 31, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28337021/different-drugs-for-bad-bugs-antivirulence-strategies-in-the-age-of-antibiotic-resistance
#11
REVIEW
Seth W Dickey, Gordon Y C Cheung, Michael Otto
The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens are outpacing the development of new antibiotics, but antivirulence agents provide an alternative. These agents can circumvent antibiotic resistance by disarming pathogens of virulence factors that facilitate human disease while leaving bacterial growth pathways - the target of traditional antibiotics - intact. Either as stand-alone medications or together with antibiotics, these drugs are intended to treat bacterial infections in a largely pathogen-specific manner...
March 24, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28337020/delivery-technologies-for-genome-editing
#12
REVIEW
Hao Yin, Kevin J Kauffman, Daniel G Anderson
With the recent development of CRISPR technology, it is becoming increasingly easy to engineer the genome. Genome-editing systems based on CRISPR, as well as transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs), are becoming valuable tools for biomedical research, drug discovery and development, and even gene therapy. However, for each of these systems to effectively enter cells of interest and perform their function, efficient and safe delivery technologies are needed. This Review discusses the principles of biomacromolecule delivery and gene editing, examines recent advances and challenges in non-viral and viral delivery methods, and highlights the status of related clinical trials...
March 24, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28303026/strategies-and-challenges-for-the-next-generation-of-antibody-drug-conjugates
#13
REVIEW
Alain Beck, Liliane Goetsch, Charles Dumontet, Nathalie Corvaïa
Antibody-drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) and trastuzumab emtansine (in 2013) have paved the way for ongoing clinical trials that are evaluating more than 60 further ADC candidates. The limited success of first-generation ADCs (developed in the early 2000s) informed strategies to bring second-generation ADCs to the market, which have higher levels of cytotoxic drug conjugation, lower levels of naked antibodies and more-stable linkers between the drug and the antibody...
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28303025/targeting-glutamate-signalling-in-depression-progress-and-prospects
#14
REVIEW
James W Murrough, Chadi G Abdallah, Sanjay J Mathew
Major depressive disorder (MDD) is severely disabling, and current treatments have limited efficacy. The glutamate N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine was recently repurposed as a rapidly acting antidepressant, catalysing the vigorous investigation of glutamate-signalling modulators as novel therapeutic agents for depressive disorders. In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants...
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28303024/lessons-from-immuno-oncology-a-new-era-for-cancer-nanomedicine
#15
Wen Jiang, Hengfeng Yuan, Charles K Chan, Christina A von Roemeling, Zuoqin Yan, Irving L Weissman, Betty Y S Kim
Despite a decade of intensive preclinical research, the translation of cancer nanomedicine to the clinic has been slow. Here, we discuss how recent lessons learned from the successes with immuno-oncology therapies could be applied to cancer nanomedicine and how this may help to overcome some of the key technical challenges in this field.
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28303023/market-watch-upcoming-market-catalysts-in-q2-2017
#16
Eric Ho
No abstract text is available yet for this article.
March 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28280261/non-kinase-targets-of-protein-kinase-inhibitors
#17
REVIEW
Lenka Munoz
Kinome-wide profiling platforms have comprehensively identified the relevant kinases that are targeted by numerous protein kinase inhibitors. However, recent projects have begun to discover non-kinase targets of kinase inhibitors. These non-kinase targets can contribute to the desired or undesired activities of inhibitors, or act as silent bystanders. As a full awareness of a drug's mechanism of action is crucial for the interpretation of results and for successful preclinical and clinical drug development, these discoveries highlight the importance of understanding the pharmacology of kinase inhibitors beyond the kinome...
March 10, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28280260/trends-in-the-market-for-antihypertensive-drugs
#18
M Adam Ali, Salman Rizvi, Basharut A Syed
No abstract text is available yet for this article.
March 10, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28280259/patent-watch-patent-insight-into-polymer-free-drug-eluting-stents
#19
Vadim Demidov, Daniel Currie, Justin Wen
No abstract text is available yet for this article.
March 10, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28232726/accelerating-development-of-scientific-evidence-for-medical-products-within-the-existing-us-regulatory-framework
#20
Rachel E Sherman, Kathleen M Davies, Melissa A Robb, Nina L Hunter, Robert M Califf
Growing access to diverse 'real-world' data sources is enabling new approaches to close persistent evidence gaps about the optimal use of medical products in real-world practice. Here, we argue that contrary to widespread impressions, existing FDA regulations embody sufficient flexibility to accommodate the emerging tools and methods needed to achieve this goal.
February 24, 2017: Nature Reviews. Drug Discovery
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