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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/28642610/the-multiple-sclerosis-market
#1
Anders Westad, Aditya Venugopal, Eric Snyder
No abstract text is available yet for this article.
June 23, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28620177/market-watch-upcoming-market-catalysts-in-q3-2017
#2
Sonny Nghiem
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28620176/g-protein-coupled-receptors-crystal-structure-of-glucagon-family-receptors
#3
Sarah Crunkhorn
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28620175/ageing-old-bone-removal
#4
M Teresa Villanueva
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28620174/genetic-disorders-repurposing-metformin-in-fxs
#5
Sarah Crunkhorn
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28620173/cancer-targeting-myc-driven-translation
#6
Sarah Crunkhorn
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28620172/endocrinology-reducing-fat-and-building-bone
#7
Sarah Crunkhorn
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28596533/breaking-barriers-to-novel-analgesic-drug-development
#8
REVIEW
Ajay S Yekkirala, David P Roberson, Bruce P Bean, Clifford J Woolf
Acute and chronic pain complaints, although common, are generally poorly served by existing therapies. This unmet clinical need reflects a failure to develop novel classes of analgesics with superior efficacy, diminished adverse effects and a lower abuse liability than those currently available. Reasons for this include the heterogeneity of clinical pain conditions, the complexity and diversity of underlying pathophysiological mechanisms, and the unreliability of some preclinical pain models. However, recent advances in our understanding of the neurobiology of pain are beginning to offer opportunities for developing novel therapeutic strategies and revisiting existing targets, including modulating ion channels, enzymes and G-protein-coupled receptors...
June 9, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28546548/the-ovarian-cancer-drug-market
#9
Jennifer Bamford, Rachel M Webster
No abstract text is available yet for this article.
May 26, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28529321/colorectal-cancer-drugs-market
#10
Sorcha Cassidy, Basharut A Syed
No abstract text is available yet for this article.
May 19, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28529319/therapeutic-targeting-of-the-angiopoietin-tie-pathway
#11
REVIEW
Pipsa Saharinen, Lauri Eklund, Kari Alitalo
The endothelial angiopoietin (ANG)-TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG-TIE pathway are in clinical development for oncological and ophthalmological applications. The aim is to complement current vascular endothelial growth factor (VEGF)-based anti-angiogenic therapies in cancer, wet age-related macular degeneration and macular oedema. The unique function of the ANG-TIE pathway in vascular stabilization also renders this pathway an attractive target in sepsis, organ transplantation, atherosclerosis and vascular complications of diabetes...
May 19, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28529317/how-much-do-clinical-trials-cost
#12
Linda Martin, Melissa Hutchens, Conrad Hawkins, Alaina Radnov
No abstract text is available yet for this article.
May 19, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28529316/pharmacological-modulation-of-autophagy-therapeutic-potential-and-persisting-obstacles
#13
REVIEW
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Beth Levine, Douglas R Green, Guido Kroemer
Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic...
May 19, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28496147/combination-products-modernizing-the-regulatory-paradigm
#14
Nina L Hunter, Rachel E Sherman
New opportunities to develop innovative - and often complex - products that combine drugs, devices and/or biological components are rapidly emerging, raising questions about how such products should be regulated. Here, we discuss the ongoing efforts of the FDA to develop a modern, transparent, flexible and consistent science-based regulatory approach for combination products.
May 12, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28496146/the-antifungal-pipeline-a-reality-check
#15
REVIEW
John R Perfect
Invasive fungal infections continue to appear in record numbers as the immunocompromised population of the world increases, owing partially to the increased number of individuals who are infected with HIV and partially to the successful treatment of serious underlying diseases. The effectiveness of current antifungal therapies - polyenes, flucytosine, azoles and echinocandins (as monotherapies or in combinations for prophylaxis, or as empiric, pre-emptive or specific therapies) - in the management of these infections has plateaued...
May 12, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28496145/market-watch-trends-in-pharmaceutical-company-r-d-spending-2005-2015
#16
Richa Dixit, Frank S David
No abstract text is available yet for this article.
May 12, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28473729/broad-spectrum-agents-for-flaviviral-infections-dengue-zika-and-beyond
#17
REVIEW
Veaceslav Boldescu, Mira A M Behnam, Nikos Vasilakis, Christian D Klein
Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis...
May 5, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28473728/market-watch-landscape-for-medical-countermeasure-development
#18
Christopher Milne, Zachary Peter Smith, Ranjana Chakravarthy
No abstract text is available yet for this article.
May 5, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28450744/bridging-the-translational-innovation-gap-through-good-biomarker-practice
#19
Alain J van Gool, Florence Bietrix, Eric Caldenhoven, Kurt Zatloukal, Andreas Scherer, Jan-Eric Litton, Gerrit Meijer, Niklas Blomberg, Andy Smith, Barend Mons, Jaap Heringa, Wim-Jan Koot, Martin J Smit, Marian Hajduch, Ton Rijnders, Anton Ussi
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28450743/implications-of-cancer-evolution-for-drug-development
#20
Samra Turajlic, Charles Swanton
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Drug Discovery
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