journal
MENU ▼
Read by QxMD icon Read
search

Nature Reviews. Drug Discovery

journal
https://www.readbyqxmd.com/read/30410121/gpcr-drug-discovery-integrating-solution-nmr-data-with-crystal-and-cryo-em-structures
#1
REVIEW
Ichio Shimada, Takumi Ueda, Yutaka Kofuku, Matthew T Eddy, Kurt Wüthrich
The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key physiological processes and thus have long been attractive drug targets. With the crystal structures of more than 50 different human GPCRs determined over the past decade, an initial platform for structure-based rational design has been established for drugs that target GPCRs, which is currently being augmented with cryo-electron microscopy (cryo-EM) structures of higher-order GPCR complexes. Nuclear magnetic resonance (NMR) spectroscopy in solution is one of the key approaches for expanding this platform with dynamic features, which can be accessed at physiological temperature and with minimal modification of the wild-type GPCR covalent structures...
November 9, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30393373/mitochondria-as-a-therapeutic-target-for-common-pathologies
#2
REVIEW
Michael P Murphy, Richard C Hartley
Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins, it has been found that mitochondrial dysfunction also contributes to the pathology of many common disorders, including neurodegeneration, metabolic disease, heart failure, ischaemia-reperfusion injury and protozoal infections. Mitochondria therefore represent an important drug target for these highly prevalent diseases. Several strategies aimed at therapeutically restoring mitochondrial function are emerging, and a small number of agents have entered clinical trials...
November 5, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30361553/trends-in-the-global-immuno-oncology-landscape
#3
Jun Tang, Laura Pearce, Jill O'Donnell-Tormey, Vanessa M Hubbard-Lucey
This corrects the article DOI: 10.1038/nrd.2018.167.
October 26, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30361552/targeting-macrophages-therapeutic-approaches-in-cancer
#4
REVIEW
Luca Cassetta, Jeffrey W Pollard
Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages promote cancer initiation and malignant progression by stimulating angiogenesis, increasing tumour cell migration, invasion and intravasation and suppressing antitumour immunity. At metastatic sites, macrophages promote tumour cell extravasation, survival and subsequent growth. Each of these pro-tumoural activities is promoted by a subpopulation of macrophages that express canonical markers but have unique transcriptional profiles, which makes tumour-associated macrophages (TAMs) good targets for anticancer therapy in humans through either their ablation or their re-differentiation away from pro-tumoural towards antitumoural states...
October 26, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30337723/antibacterial-agents-new-antibiotic-hits-gram-negative-bacteria
#5
Katie Kingwell
No abstract text is available yet for this article.
October 19, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30337722/trends-in-the-global-immuno-oncology-landscape
#6
Jun Tang, Laura Pearce, Jill O'Donnell-Tormey, Vanessa M Hubbard-Lucey
No abstract text is available yet for this article.
October 19, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30337721/antibacterial-agents-gallium-fights-infection-in-phase-i-trial
#7
Sarah Crunkhorn
No abstract text is available yet for this article.
October 19, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30337720/cancer-epilepsy-caused-by-braf-mutated-paediatric-brain-tumours-gets-a-rest
#8
Megan Cully
No abstract text is available yet for this article.
October 19, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30310236/therapeutic-strategies-targeting-connexins
#9
REVIEW
Dale W Laird, Paul D Lampe
The connexin family of channel-forming proteins is present in every tissue type in the human anatomy. Connexins are best known for forming clustered intercellular channels, structurally known as gap junctions, where they serve to exchange members of the metabolome between adjacent cells. In their single-membrane hemichannel form, connexins can act as conduits for the passage of small molecules in autocrine and paracrine signalling. Here, we review the roles of connexins in health and disease, focusing on the potential of connexins as therapeutic targets in acquired and inherited diseases as well as wound repair, while highlighting the associated clinical challenges...
October 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30310235/patent-watch-selective-gaba-a-receptor-modulators-intellectual-property-landscape
#10
Cecilia Martin, Drew Lowery
No abstract text is available yet for this article.
October 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30310234/regulatory-t-cells-in-the-treatment-of-disease
#11
REVIEW
Amir Sharabi, Maria G Tsokos, Ying Ding, Thomas R Malek, David Klatzmann, George C Tsokos
Regulatory T (Treg ) cells suppress inflammation and regulate immune system activity. In patients with systemic or organ-specific autoimmune diseases or those receiving transplanted organs, Treg cells are compromised. Approaches to strengthen Treg cell function, either by expanding them ex vivo and reinfusing them or by increasing the number or capacity of existing Treg cells, have entered clinical trials. Unlike the situation in autoimmunity, in patients with cancer, Treg cells limit the antitumour immune response and promote angiogenesis and tumour growth...
October 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30310233/drug-repurposing-progress-challenges-and-recommendations
#12
REVIEW
Sudeep Pushpakom, Francesco Iorio, Patrick A Eyers, K Jane Escott, Shirley Hopper, Andrew Wells, Andrew Doig, Tim Guilliams, Joanna Latimer, Christine McNamee, Alan Norris, Philippe Sanseau, David Cavalla, Munir Pirmohamed
Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines. Various data-driven and experimental approaches have been suggested for the identification of repurposable drug candidates; however, there are also major technological and regulatory challenges that need to be addressed...
October 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30310232/cancer-stem-cell-pipeline-flounders
#13
Ken Garber
No abstract text is available yet for this article.
October 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30310231/therapeutic-strategies-for-parkinson-disease-beyond-dopaminergic-drugs
#14
Delphine Charvin, Rossella Medori, Robert A Hauser, Olivier Rascol
This corrects the article DOI: 10.1038/nrd.2018.136.
October 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30262888/reforming-china-s-drug-regulatory-system
#15
Lili Xu, Huijun Gao, Kenneth I Kaitin, Liming Shao
No abstract text is available yet for this article.
September 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30206385/defining-orphan-conditions-in-the-context-of-the-european-orphan-regulation-challenges-and-evolution
#16
Daniel J O'Connor, Maria E Sheean, Matthias P Hofer, Stelios Tsigkos, Segundo Mariz, Laura Fregonese, Kristina Larsson, Virginie Hivert, Kerstin Westermark, Frauke Naumann-Winter, Violeta Stoyanova-Beninska, Ingeborg Barišić, Giuseppe Capovilla, Armando Magrelli, Bruno Sepodes
The definition and acceptability of an orphan condition is pivotal for the assessment of European orphan medicinal product designation applications, and consequently the eligibility for incentives. Here, based on the experiences of the Committee for Orphan Medicinal Products, we discuss how to define orphan conditions in the context of the European regulatory framework.
September 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30168534/the-hepatocellular-carcinoma-market
#17
Joshua Dawkins, Rachel M Webster
No abstract text is available yet for this article.
August 31, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282375/can-innate-immune-system-targets-turn-up-the-heat-on-cold-tumours
#18
Asher Mullard
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282372/market-watch-upcoming-market-catalysts-in-q1-2018
#19
Tanner Collins
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30262890/targeting-g-protein-coupled-receptor-signalling-by-blocking-g-proteins
#20
REVIEW
Adrian P Campbell, Alan V Smrcka
G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiological efficacy. Many drugs selectively target specific subtypes of GPCRs, but high specificity for individual GPCRs may not be desirable in complex multifactorial disease states in which multiple receptors may be involved. One approach is to target G protein subunits rather than the GPCRs directly. This approach has the potential to achieve broad efficacy by blocking pathways shared by multiple GPCRs...
November 2018: Nature Reviews. Drug Discovery
journal
journal
39817
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"