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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/28935918/host-directed-therapies-for-bacterial-and-viral-infections
#1
REVIEW
Stefan H E Kaufmann, Anca Dorhoi, Richard S Hotchkiss, Ralf Bartenschlager
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and additional alternative approaches to treat infectious diseases are urgently needed. Host-directed therapy (HDT) is an emerging approach in the field of anti-infectives. The strategy behind HDT is to interfere with host cell factors that are required by a pathogen for replication or persistence, to enhance protective immune responses against a pathogen, to reduce exacerbated inflammation and to balance immune reactivity at sites of pathology...
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935917/cns-injury-promoting-neural-repair
#2
Sarah Crunkhorn
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935916/infectious-disease-blocking-malaria-transmission
#3
Sarah Crunkhorn
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935915/rna-based-therapeutics-increasing-efficacy
#4
Sarah Crunkhorn
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935914/neurodegenerative-disease-dlk-zips-across-neurodegeneration
#5
M Teresa Villanueva
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935913/katrine-bosley
#6
(no author information available yet)
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935912/neurological-disorders-reversing-rett-syndrome
#7
Sarah Crunkhorn
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935911/directing-evolution-the-next-revolution-in-drug-discovery
#8
REVIEW
Andrew M Davis, Alleyn T Plowright, Eric Valeur
The strong biological rationale to pursue challenging drug targets such as protein-protein interactions has stimulated the development of novel screening strategies, such as DNA-encoded libraries, to allow broader areas of chemical space to be searched. There has also been renewed interest in screening natural products, which are the result of evolutionary selection for a function, such as interference with a key signalling pathway of a competing organism. However, recent advances in several areas, such as understanding of the biosynthetic pathways for natural products, synthetic biology and the development of biosensors to detect target molecules, are now providing new opportunities to directly harness evolutionary pressure to identify and optimize compounds with desired bioactivities...
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935910/autoimmune-disease-lkb1-helps-treg-cells-battle-exhaustion
#9
Megan Cully
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935909/synthetic-lethality-screens-point-the-way-to-new-cancer-drug-targets
#10
Asher Mullard
This corrects the article DOI: 10.1038/nrd.2017.165.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28935908/biometric-monitoring-devices-for-assessing-end-points-in-clinical-trials-developing-an-ecosystem
#11
Stephen P Arnerić, Jesse M Cedarbaum, Sean Khozin, Spyros Papapetropoulos, Derek L Hill, Michael Ropacki, Jane Rhodes, Penny A Dacks, Lynn D Hudson, Mark Forrest Gordon, Volker D Kern, Klaus Romero, George Vradenburg, Rhoda Au, Daniel R Karlin, Maurizio F Facheris, Cheryl J Fitzer-Attas, Ottavio V Vitolo, Jian Wang, Bradley M Miller, Jeffrey A Kaye
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28912600/the-human-microbiome-opportunity-or-hype
#12
Pedro M Valencia, Magali Richard, Jesse Brock, Elsy Boglioli
No abstract text is available yet for this article.
September 15, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28912599/market-watch-upcoming-market-catalysts-in-q4-2017
#13
Gregory Pak
No abstract text is available yet for this article.
September 15, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28912598/synthetic-lethality-screens-point-the-way-to-new-cancer-drug-targets
#14
Asher Mullard
No abstract text is available yet for this article.
September 15, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28883664/patent-watch-the-evolving-intellectual-property-landscape-for-pruritus-therapies
#15
Benjamin Leung, Drew Lowery
No abstract text is available yet for this article.
September 8, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28860647/flexibility-in-the-fda-approach-to-orphan-drug-development
#16
Nina L Hunter, Gayatri R Rao, Rachel E Sherman
No abstract text is available yet for this article.
September 1, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28819327/inflammatory-diseases-an-il-9-solution-to-inflammation-resolution
#17
Megan Cully
No abstract text is available yet for this article.
August 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28819326/pulling-away-from-the-pack-in-drug-launches
#18
Nicholas Donoghoe, Jon Duane, Jin Kim, George Xu
No abstract text is available yet for this article.
August 18, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28799542/regulatory-watch-structural-and-procedural-characteristics-of-international-regulatory-authorities
#19
Anand B Jain, Annette Mollet, Thomas D Szucs
No abstract text is available yet for this article.
August 11, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28775338/nih-centers-for-accelerated-innovations-program-principles-practices-successes-and-challenges
#20
Elliott M Antman, Paul E Di Corleto, Mason W Freeman, Tomas Ganz, David E Golan, Roger Kitterman, Joseph Loscalzo, Mark Low, Erin McKenna, Alan C O'Connor, Michael Palazzolo, John Parrish, Ofer Reizes, Robert S Ross, Cheryl Vaughan, D Geoffrey Vince, Lesley Watts
No abstract text is available yet for this article.
August 4, 2017: Nature Reviews. Drug Discovery
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