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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/29773919/neuroscience-reconnecting-the-brain-after-injury
#1
M Teresa Villanueva
No abstract text is available yet for this article.
May 18, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29773918/rna-modifying-proteins-as-anticancer-drug-targets
#2
REVIEW
P Ann Boriack-Sjodin, Scott Ribich, Robert A Copeland
All major biological macromolecules (DNA, RNA, proteins and lipids) undergo enzyme-catalysed covalent modifications that impact their structure, function and stability. A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA stability and translation to proteins; these mechanisms of translational control have been termed epitranscriptomics. Emerging data suggest that some epitranscriptomic mechanisms are altered in human cancers as well as other human diseases. In this Review, we examine the current understanding of RNA modifications with a focus on mRNA methylation, highlight their possible roles in specific cancer indications and discuss the emerging potential of RNA-modifying proteins as therapeutic targets...
May 18, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29773917/neurodegenerative-disorders-rescuing-mitochondrial-motility
#3
Sarah Crunkhorn
No abstract text is available yet for this article.
May 18, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29773916/the-haemophilia-drug-market
#4
Kerri Brown, Graeme Green
No abstract text is available yet for this article.
May 18, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29773915/antibacterial-drugs-disrupting-mrsa-persisters
#5
Conor A Bradley
No abstract text is available yet for this article.
May 18, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29725132/post-exposure-treatments-for-ebola-and-marburg-virus-infections
#6
Robert W Cross, Chad E Mire, Heinz Feldmann, Thomas W Geisbert
This corrects the article DOI: 10.1038/nrd.2017.251.
May 4, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29725131/interleukin-6-designing-specific-therapeutics-for-a-complex-cytokine
#7
REVIEW
Christoph Garbers, Sylvia Heink, Thomas Korn, Stefan Rose-John
Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological functions that include regulation of immune cell proliferation and differentiation. Dysregulation of IL-6 signalling is associated with inflammatory and lymphoproliferative disorders such as rheumatoid arthritis and Castleman disease, and several classes of therapeutics have been developed that target components of the IL-6 signalling pathway. So far, monoclonal antibodies against IL-6 or IL-6 receptor (IL-6R) and Janus kinases (JAK) inhibitors have been successfully developed for the treatment of autoimmune diseases such as rheumatoid arthritis...
May 4, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29700501/the-expanding-role-of-prodrugs-in-contemporary-drug-design-and-development
#8
REVIEW
Jarkko Rautio, Nicholas A Meanwell, Li Di, Michael J Hageman
Prodrugs are molecules with little or no pharmacological activity that are converted to the active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two. Prodrugs have evolved from being serendipitously discovered or used as a salvage effort to being intentionally designed. Such efforts can avoid drug development challenges that limit formulation options or result in unacceptable biopharmaceutical or pharmacokinetic performance, or poor targeting. In the past 10 years, the US Food and Drug Administration has approved at least 30 prodrugs, which accounts for more than 12% of all approved small-molecule new chemical entities...
April 27, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29674700/what-drives-site-performance-in-clinical-trials
#9
Brendan Smith, Linda Martin, Scott Martin, Maria Denslow, Melissa Hutchens, Conrad Hawkins, Valery Panier, Michael S Ringel
No abstract text is available yet for this article.
April 20, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29674698/translating-translation
#10
Christopher P Austin
No abstract text is available yet for this article.
April 20, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29651106/senotherapeutics-for-healthy-ageing
#11
Laura J Niedernhofer, Paul D Robbins
No abstract text is available yet for this article.
April 13, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29622786/informed-an-incubator-at-the-us-fda-for-driving-innovations-in-data-science-and-agile-technology
#12
Sean Khozin, Richard Pazdur, Anand Shah
No abstract text is available yet for this article.
April 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29567994/accelerating-the-development-of-therapeutic-strategies-for-drug-resistant-tuberculosis
#13
Michael J Vjecha, Simon Tiberi, Alimuddin Zumla
Recent progress in the discovery, development and evaluation of new drugs and combination regimens for drug-resistant tuberculosis through greater collaboration between industry, donors and academia provides renewed hope for overcoming the challenges in tuberculosis treatment.
March 23, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29567993/unexplored-therapeutic-opportunities-in-the-human-genome
#14
Tudor I Oprea, Cristian G Bologa, Søren Brunak, Allen Campbell, Gregory N Gan, Anna Gaulton, Shawn M Gomez, Rajarshi Guha, Anne Hersey, Jayme Holmes, Ajit Jadhav, Lars Juhl Jensen, Gary L Johnson, Anneli Karlson, Andrew R Leach, Avi Ma'ayan, Anna Malovannaya, Subramani Mani, Steven L Mathias, Michael T McManus, Terrence F Meehan, Christian von Mering, Daniel Muthas, Dac-Trung Nguyen, John P Overington, George Papadatos, Jun Qin, Christian Reich, Bryan L Roth, Stephan C Schürer, Anton Simeonov, Larry A Sklar, Noel Southall, Susumu Tomita, Ilinca Tudose, Oleg Ursu, Dušica Vidovic, Anna Waller, David Westergaard, Jeremy J Yang, Gergely Zahoránszky-Köhalmi
This corrects the article DOI: 10.1038/nrd.2018.14.
March 23, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282375/can-innate-immune-system-targets-turn-up-the-heat-on-cold-tumours
#15
Asher Mullard
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282372/market-watch-upcoming-market-catalysts-in-q1-2018
#16
Tanner Collins
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29674699/cancer-mopping-up-a-molecule-for-breast-cancer-survival
#17
Megan Cully
No abstract text is available yet for this article.
May 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29674697/metabolic-disease-liver-enzyme-inflames-fat
#18
Sarah Crunkhorn
No abstract text is available yet for this article.
May 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29674696/cancer-immunotherapy-the-perfect-match
#19
M Teresa Villanueva
No abstract text is available yet for this article.
May 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29651105/chemical-probes-and-drug-leads-from-advances-in-synthetic-planning-and-methodology
#20
REVIEW
Christopher J Gerry, Stuart L Schreiber
Screening of small-molecule libraries is a productive method for identifying both chemical probes of disease-related targets and potential starting points for drug discovery. In this article, we focus on strategies such as diversity-oriented synthesis that aim to explore novel areas of chemical space efficiently by populating small-molecule libraries with compounds containing structural features that are typically under-represented in commercially available screening collections. Drawing from more than a decade's worth of examples, we highlight how the design and synthesis of such libraries have been enabled by modern synthetic chemistry, and we illustrate the impact of the resultant chemical probes and drug leads in a wide range of diseases...
May 2018: Nature Reviews. Drug Discovery
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