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Asher Mullard
No abstract text is available yet for this article.
April 17, 2024: Nature Reviews. Drug Discovery
#2
Patrick Flynn, Smruthi Suryaprakash, Dan Grossman, Val Panier, John Wu
No abstract text is available yet for this article.
April 16, 2024: Nature Reviews. Drug Discovery
#3
REVIEW
Lorenzo Galluzzi, Emma Guilbaud, Darby Schmidt, Guido Kroemer, Francesco M Marincola
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific stressors, occupies a central position in the development of novel anticancer treatments. Several therapeutic strategies to elicit ICD - either as standalone approaches or as means to convert immunologically cold tumours that are insensitive to immunotherapy into hot and immunotherapy-sensitive lesions - are being actively pursued. However, the development of ICD-inducing treatments is hindered by various obstacles...
April 15, 2024: Nature Reviews. Drug Discovery
#4
Paul Verdin
No abstract text is available yet for this article.
April 12, 2024: Nature Reviews. Drug Discovery
#5
M Teresa Villanueva
No abstract text is available yet for this article.
April 11, 2024: Nature Reviews. Drug Discovery
#6
Asher Mullard
No abstract text is available yet for this article.
April 11, 2024: Nature Reviews. Drug Discovery
#7
Asher Mullard
No abstract text is available yet for this article.
April 11, 2024: Nature Reviews. Drug Discovery
#8
Alex Eccleston
No abstract text is available yet for this article.
April 9, 2024: Nature Reviews. Drug Discovery
#9
Sarah Crunkhorn
No abstract text is available yet for this article.
April 4, 2024: Nature Reviews. Drug Discovery
#10
Sarah Crunkhorn
No abstract text is available yet for this article.
April 4, 2024: Nature Reviews. Drug Discovery
#11
Sarah Crunkhorn
No abstract text is available yet for this article.
April 4, 2024: Nature Reviews. Drug Discovery
#12
Sarah Crunkhorn
No abstract text is available yet for this article.
April 4, 2024: Nature Reviews. Drug Discovery
#13
REVIEW
Qi Tang, Anastasia Khvorova
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming pharmaceutical development, proved by the recent FDA approval of multiple small interfering RNA (siRNA) drugs that target the liver. Synthetic siRNAs that trigger RNAi have the potential to specifically silence virtually any therapeutic target with unprecedented potency and durability. Bringing this innovative class of medicines to patients, however, has been riddled with substantial challenges, with delivery issues at the forefront...
April 3, 2024: Nature Reviews. Drug Discovery
#14
Sorin Avram, Liliana Halip, Ramona Curpan, Tudor I Oprea
No abstract text is available yet for this article.
April 2, 2024: Nature Reviews. Drug Discovery
#15
REVIEW
Zachary Fralish, Ashley Chen, Shaharyar Khan, Pei Zhou, Daniel Reker
Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which undergo biotransformation after administration to generate the API in situ. Although sharing this general characteristic, prodrugs encompass a wide range of different chemical structures, therapeutic indications and properties. Here we provide the first holistic analysis of the current landscape of approved prodrugs using cheminformatics and data science approaches to reveal trends in prodrug development...
April 2, 2024: Nature Reviews. Drug Discovery
#16
Asher Mullard
No abstract text is available yet for this article.
March 28, 2024: Nature Reviews. Drug Discovery
#17
Sarah Crunkhorn
No abstract text is available yet for this article.
March 28, 2024: Nature Reviews. Drug Discovery
#18
Katie Kingwell
No abstract text is available yet for this article.
March 27, 2024: Nature Reviews. Drug Discovery
#19
Katie Kingwell
No abstract text is available yet for this article.
March 20, 2024: Nature Reviews. Drug Discovery
#20
Anna Tavridou, Dolça Rogers, Giada Farinelli, Iordanis Gravanis, Veronika Jekerle
No abstract text is available yet for this article.
March 15, 2024: Nature Reviews. Drug Discovery
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