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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/30237455/ageing-reversing-muscle-degeneration
#1
Sarah Crunkhorn
No abstract text is available yet for this article.
September 21, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30237454/therapeutic-approaches-to-huntington-disease-from-the-bench-to-the-clinic
#2
REVIEW
Nicholas S Caron, E Ray Dorsey, Michael R Hayden
The 25 years since the identification of the gene responsible for Huntington disease (HD) have stood witness to profound discoveries about the nature of the disease and its pathogenesis. Despite this progress, however, the development of disease-modifying therapies has thus far been slow. Preclinical validation of the therapeutic potential of disrupted pathways in HD has led to the advancement of pharmacological agents, both novel and repurposed, for clinical evaluation. The most promising therapeutic approaches include huntingtin (HTT) lowering and modification as well as modulation of neuroinflammation and synaptic transmission...
September 21, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30237453/genetic-disorders-bacterial-therapeutic-steps-into-the-breach
#3
Katie Kingwell
No abstract text is available yet for this article.
September 21, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30237452/neurodegenerative-diseases-ropin-in-als
#4
Megan Cully
No abstract text is available yet for this article.
September 21, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30237451/cancer-immunotherapy-when-a-car-becomes-a-tank
#5
M Teresa Villanueva
No abstract text is available yet for this article.
September 21, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30206385/defining-orphan-conditions-in-the-context-of-the-european-orphan-regulation-challenges-and-evolution
#6
Daniel J O'Connor, Maria E Sheean, Matthias P Hofer, Stelios Tsigkos, Segundo Mariz, Laura Fregonese, Kristina Larsson, Virginie Hivert, Kerstin Westermark, Frauke Naumann-Winter, Violeta Stoyanova-Beninska, Ingeborg Barišić, Giuseppe Capovilla, Armando Magrelli, Bruno Sepodes
The definition and acceptability of an orphan condition is pivotal for the assessment of European orphan medicinal product designation applications, and consequently the eligibility for incentives. Here, based on the experiences of the Committee for Orphan Medicinal Products, we discuss how to define orphan conditions in the context of the European regulatory framework.
September 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30206384/gene-therapy-for-neurological-disorders-progress-and-prospects
#7
Benjamin E Deverman, Bernard M Ravina, Krystof S Bankiewicz, Steven M Paul, Dinah W Y Sah
This corrects the article DOI: 10.1038/nrd.2018.110.
September 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30190565/an-rna-toolbox-for-cancer-immunotherapy
#8
REVIEW
Fernando Pastor, Pedro Berraondo, Iñaki Etxeberria, Josh Frederick, Ugur Sahin, Eli Gilboa, Ignacio Melero
Cancer immunotherapy has revolutionized oncology practice. However, current protein and cell therapy tools used in cancer immunotherapy are far from perfect, and there is room for improvement regarding their efficacy and safety. RNA-based structures have diverse functions, ranging from gene expression and gene regulation to pro-inflammatory effects and the ability to specifically bind different molecules. These functions make them versatile tools that may advance cancer vaccines and immunomodulation, surpassing existing approaches...
September 7, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30168534/the-hepatocellular-carcinoma-market
#9
Joshua Dawkins, Rachel M Webster
No abstract text is available yet for this article.
August 31, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30140018/expanding-the-medicinal-chemistry-synthetic-toolbox
#10
REVIEW
Jonas Boström, Dean G Brown, Robert J Young, György M Keserü
The key objectives of medicinal chemistry are to efficiently design and synthesize bioactive compounds that have the potential to become safe and efficacious drugs. Most medicinal chemistry programmes rely on screening compound collections populated by a range of molecules derived from a set of known and robust chemistry reactions. Analysis of the role of synthetic organic chemistry in subsequent hit and lead optimization efforts suggests that only a few reactions dominate. Thus, the uptake of new synthetic methodologies in drug discovery is limited...
August 24, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30026528/trends-driving-clinical-trials-into-large-clinical-care-settings
#11
Kenneth Getz
No abstract text is available yet for this article.
July 20, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29977052/the-evolution-of-adaptiveness-balancing-speed-and-evidence
#12
Hans-Georg Eichler, Richard Barker, Nicola Bedlington, Jacoline C Bouvy, André W Broekmans, Anna Bucsics, Francesca Cerreta, Solange Corriol-Rohou, Alicia Granados, Yann Le Cam, Ad Schuurman
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29977050/a-call-for-a-global-bigger-data-approach-to-alzheimer-disease
#13
Eric Perakslis, Henry Riordan, Lawrence Friedhoff, Azmi Nabulsi, Emilio Merlo Pich
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282375/can-innate-immune-system-targets-turn-up-the-heat-on-cold-tumours
#14
Asher Mullard
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282372/market-watch-upcoming-market-catalysts-in-q1-2018
#15
Tanner Collins
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30116052/gene-therapy-gene-therapy-before-the-cradle
#16
M Teresa Villanueva
No abstract text is available yet for this article.
September 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30116051/promoting-the-clearance-of-neurotoxic-proteins-in-neurodegenerative-disorders-of-ageing
#17
REVIEW
Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M Pastores, David C Rubinsztein, Ralph A Nixon, Michael R Duchen, Giovanna R Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R Martin, Mark J Millan
Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. They are often called 'proteinopathies' owing to the presence of misfolded and aggregated proteins that lose their physiological roles and acquire neurotoxic properties. One reason underlying the accumulation and spread of oligomeric forms of neurotoxic proteins is insufficient clearance by the autophagic-lysosomal network...
September 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30116050/regenerative-medicine-stem-cell-derived-cardiomyocytes-heal-a-broken-heart
#18
Grant Otto
No abstract text is available yet for this article.
September 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30116049/new-approaches-and-challenges-to-targeting-the-endocannabinoid-system
#19
REVIEW
Vincenzo Di Marzo
The endocannabinoid signalling system was discovered because receptors in this system are the targets of compounds present in psychotropic preparations of Cannabis sativa. The search for new therapeutics that target endocannabinoid signalling is both challenging and potentially rewarding, as endocannabinoids are implicated in numerous physiological and pathological processes. Hundreds of mediators chemically related to the endocannabinoids, often with similar metabolic pathways but different targets, have complicated the development of inhibitors of endocannabinoid metabolic enzymes but have also stimulated the rational design of multi-target drugs...
September 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30116048/pain-silencing-chronic-pain-with-botulinum-toxin
#20
Sarah Crunkhorn
No abstract text is available yet for this article.
September 2018: Nature Reviews. Drug Discovery
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