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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/28082745/the-scchn-drug-market
#1
Jennifer Bamford, Rachel M Webster
No abstract text is available yet for this article.
January 13, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28082744/strategies-for-delivering-value-from-digital-technology-transformation
#2
Eric D Perakslis
No abstract text is available yet for this article.
January 13, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28057932/dynamic-versus-static-biomarkers-in-cancer-immune-checkpoint-blockade-unravelling-complexity
#3
W Joost Lesterhuis, Anthony Bosco, Michael J Millward, Michael Small, Anna K Nowak, Richard A Lake
Recently, there has been a coordinated effort from academic institutions and the pharmaceutical industry to identify biomarkers that can predict responses to immune checkpoint blockade in cancer. Several biomarkers have been identified; however, none has reliably predicted response in a sufficiently rigorous manner for routine use. Here, we argue that the therapeutic response to immune checkpoint blockade is a critical state transition of a complex system. Such systems are highly sensitive to initial conditions, and critical transitions are notoriously difficult to predict far in advance...
January 6, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28008169/advances-in-islet-encapsulation-technologies
#4
Tejal Desai, Lonnie D Shea
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans...
December 23, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28008168/cornerstones-of-crispr-cas-in-drug-discovery-and-therapy
#5
Christof Fellmann, Benjamin G Gowen, Pei-Chun Lin, Jennifer A Doudna, Jacob E Corn
The recent development of CRISPR-Cas systems as easily accessible and programmable tools for genome editing and regulation is spurring a revolution in biology. Paired with the rapid expansion of reference and personalized genomic sequence information, technologies based on CRISPR-Cas are enabling nearly unlimited genetic manipulation, even in previously difficult contexts, including human cells. Although much attention has focused on the potential of CRISPR-Cas to cure Mendelian diseases, the technology also holds promise to transform the development of therapies to treat complex heritable and somatic disorders...
December 23, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27980341/induced-pluripotent-stem-cell-technology-a-decade-of-progress
#6
Yanhong Shi, Haruhisa Inoue, Joseph C Wu, Shinya Yamanaka
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development. Novel pathological mechanisms have been elucidated, new drugs originating from iPSC screens are in the pipeline and the first clinical trial using human iPSC-derived products has been initiated. In particular, the combination of human iPSC technology with recent developments in gene editing and 3D organoids makes iPSC-based platforms even more powerful in each area of their application, including precision medicine...
December 16, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27932801/dna-encoded-chemistry-enabling-the-deeper-sampling-of-chemical-space
#7
Robert A Goodnow, Christoph E Dumelin, Anthony D Keefe
DNA-encoded chemical library technologies are increasingly being adopted in drug discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of chemical spaces four to five orders of magnitude more deeply than is achievable by traditional high-throughput screening methods. Operation of this technology requires developing a range of capabilities including aqueous synthetic chemistry, building block acquisition, oligonucleotide conjugation, large-scale molecular biological transformations, selection methodologies, PCR, sequencing, sequence data analysis and the analysis of large chemistry spaces...
December 9, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27885283/induced-protein-degradation-an-emerging-drug-discovery-paradigm
#8
Ashton C Lai, Craig M Crews
Small-molecule drug discovery has traditionally focused on occupancy of a binding site that directly affects protein function, and this approach typically precludes targeting proteins that lack such amenable sites. Furthermore, high systemic drug exposures may be needed to maintain sufficient target inhibition in vivo, increasing the risk of undesirable off-target effects. Induced protein degradation is an alternative approach that is event-driven: upon drug binding, the target protein is tagged for elimination...
November 25, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27857143/cancer-blocking-metastasis
#9
Sarah Crunkhorn
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27857142/antibacterial-agents-microbiome-derived-antibiotic-identified
#10
Sarah Crunkhorn
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27857141/hiv-achieving-sustained-remission
#11
Sarah Crunkhorn
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27857140/immune-disorders-blocking-the-alternative-complement-pathway
#12
Sarah Crunkhorn
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27857139/drug-design-cannabinoid-receptor-structure-revealed
#13
Sarah Crunkhorn
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27857138/market-watch-antibacterial-innovation-in-european-smes
#14
Ursula Theuretzbacher
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27857137/metabolic-disorders-hormone-conjugate-combats-metabolic-syndrome
#15
Sarah Crunkhorn
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27811931/phase-ii-and-phase-iii-failures-2013-2015
#16
Richard K Harrison
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27807347/aptamers-as-targeted-therapeutics-current-potential-and-challenges
#17
Jiehua Zhou, John Rossi
Nucleic acid aptamers, often termed 'chemical antibodies', are functionally comparable to traditional antibodies, but offer several advantages, including their relatively small physical size, flexible structure, quick chemical production, versatile chemical modification, high stability and lack of immunogenicity. In addition, many aptamers are internalized upon binding to cellular receptors, making them useful targeted delivery agents for small interfering RNAs (siRNAs), microRNAs and conventional drugs. However, several crucial factors have delayed the clinical translation of therapeutic aptamers, such as their inherent physicochemical characteristics and lack of safety data...
November 3, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27980340/trial-watch-opportunities-and-challenges-of-the-2016-target-landscape
#18
Kyle Lafferty-Whyte, David Mormeneo, Montse Del Fresno Marimon
No abstract text is available yet for this article.
January 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27910877/a-comprehensive-map-of-molecular-drug-targets
#19
Rita Santos, Oleg Ursu, Anna Gaulton, A PatrĂ­cia Bento, Ramesh S Donadi, Cristian G Bologa, Anneli Karlsson, Bissan Al-Lazikani, Anne Hersey, Tudor I Oprea, John P Overington
The success of mechanism-based drug discovery depends on the definition of the drug target. This definition becomes even more important as we try to link drug response to genetic variation, understand stratified clinical efficacy and safety, rationalize the differences between drugs in the same therapeutic class and predict drug utility in patient subgroups. However, drug targets are often poorly defined in the literature, both for launched drugs and for potential therapeutic agents in discovery and development...
January 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/27910876/drug-launch-curves-in-the-modern-era
#20
Seth Robey, Frank S David
No abstract text is available yet for this article.
January 2017: Nature Reviews. Drug Discovery
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