journal
MENU ▼
Read by QxMD icon Read
search

Nature Reviews. Drug Discovery

journal
https://www.readbyqxmd.com/read/28209992/from-basic-apoptosis-discoveries-to-advanced-selective-bcl-2-family-inhibitors
#1
REVIEW
Avi Ashkenazi, Wayne J Fairbrother, Joel D Leverson, Andrew J Souers
Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals. In cancer, apoptosis evasion through dysregulation of specific BCL-2 family genes is a recurring event; accordingly, selective inhibition of specific anti-apoptotic BCL-2 family proteins represents an exciting therapeutic opportunity. A combination of nuclear magnetic resonance (NMR)-based screening and structure-based drug design has yielded the first bona fide BCL-2 homology 3 (BH3) mimetics, including the BCL-2 and BCL-XL dual antagonist navitoclax, which is the first BCL-2 family inhibitor to show efficacy in patients with cancer...
February 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28209991/microrna-therapeutics-towards-a-new-era-for-the-management-of-cancer-and-other-diseases
#2
REVIEW
Rajesha Rupaimoole, Frank J Slack
In just over two decades since the discovery of the first microRNA (miRNA), the field of miRNA biology has expanded considerably. Insights into the roles of miRNAs in development and disease, particularly in cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches. Functional studies have confirmed that miRNA dysregulation is causal in many cases of cancer, with miRNAs acting as tumour suppressors or oncogenes (oncomiRs), and miRNA mimics and molecules targeted at miRNAs (antimiRs) have shown promise in preclinical development...
February 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28209990/antifungals-jnk-inhibitors-boost-antifungal-immunity
#3
Alexandra Flemming
No abstract text is available yet for this article.
February 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28209989/regulatory-watch-the-target-product-profile-as-a-tool-for-regulatory-communication-advantageous-but-underused
#4
Adria Tyndall, Wenny Du, Christopher D Breder
No abstract text is available yet for this article.
February 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28209988/biopharma-deal-making-in-2016
#5
Amanda Micklus, Steven Muntner
No abstract text is available yet for this article.
February 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28209987/targeting-phospholipase-d-in-cancer-infection-and-neurodegenerative-disorders
#6
REVIEW
H Alex Brown, Paul G Thomas, Craig W Lindsley
Lipid second messengers have essential roles in cellular function and contribute to the molecular mechanisms that underlie inflammation, malignant transformation, invasiveness, neurodegenerative disorders, and infectious and other pathophysiological processes. The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface receptors, including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and integrins...
February 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28184041/trial-watch-clinical-trial-cycle-times-continue-to-increase-despite-industry-efforts
#7
Linda Martin, Melissa Hutchens, Conrad Hawkins
No abstract text is available yet for this article.
February 10, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28154411/poor-medication-adherence-in-clinical-trials-consequences-and-solutions
#8
Alasdair Breckenridge, Jeffrey K Aronson, Terrence F Blaschke, Dan Hartman, Carl C Peck, Bernard Vrijens
Poor adherence to medicines in clinical trials can undermine the value of the trials; for example, by compromising estimates of the benefits and risks of a medicine. In this article, we highlight such consequences and also discuss approaches to tackle this problem.
February 3, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28154410/targeting-iron-metabolism-in-drug-discovery-and-delivery
#9
REVIEW
Bart J Crielaard, Twan Lammers, Stefano Rivella
Iron fulfils a central role in many essential biochemical processes in human physiology; thus, proper processing of iron is crucial. Although iron metabolism is subject to relatively strict physiological control, numerous disorders, such as cancer and neurodegenerative diseases, have recently been linked to deregulated iron homeostasis. Consequently, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments for these diseases. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents are likely to have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are currently available...
February 3, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28104905/applications-of-chemogenomic-library-screening-in-drug-discovery
#10
REVIEW
Lyn H Jones, Mark E Bunnage
The allure of phenotypic screening, combined with the industry preference for target-based approaches, has prompted the development of innovative chemical biology technologies that facilitate the identification of new therapeutic targets for accelerated drug discovery. A chemogenomic library is a collection of selective small-molecule pharmacological agents, and a hit from such a set in a phenotypic screen suggests that the annotated target or targets of that pharmacological agent may be involved in perturbing the observable phenotype...
January 20, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28082745/the-scchn-drug-market
#11
Jennifer Bamford, Rachel M Webster
No abstract text is available yet for this article.
January 13, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28057932/dynamic-versus-static-biomarkers-in-cancer-immune-checkpoint-blockade-unravelling-complexity
#12
REVIEW
W Joost Lesterhuis, Anthony Bosco, Michael J Millward, Michael Small, Anna K Nowak, Richard A Lake
Recently, there has been a coordinated effort from academic institutions and the pharmaceutical industry to identify biomarkers that can predict responses to immune checkpoint blockade in cancer. Several biomarkers have been identified; however, none has reliably predicted response in a sufficiently rigorous manner for routine use. Here, we argue that the therapeutic response to immune checkpoint blockade is a critical state transition of a complex system. Such systems are highly sensitive to initial conditions, and critical transitions are notoriously difficult to predict far in advance...
January 6, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28008169/advances-in-islet-encapsulation-technologies
#13
REVIEW
Tejal Desai, Lonnie D Shea
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans...
December 23, 2016: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28148948/the-immuno-oncology-race-myths-and-emerging-realities
#14
Stephen Cavnar, Pedro Valencia, Jesse Brock, Judith Wallenstein, Valery Panier
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28148947/regulatory-watch-outcomes-of-early-health-technology-assessment-dialogues-in-medicinal-product-development
#15
Fran├žois Maignen, Leeza Osipenko, Pilar Pinilla-Dominguez, Emily Crowe
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28148946/hiv-crispr-screen-identifies-novel-therapeutic-targets
#16
Sarah Crunkhorn
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28148945/fda-approves-splice-modulating-drug
#17
Asher Mullard
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28148944/ebola-vaccine-success
#18
Asher Mullard
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28148943/market-watch-value-of-2016-fda-drug-approvals-reversion-to-the-mean
#19
Ulrik Schulze, Michael Ringel, Valery Panier, Mathias Baedeker
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28148942/john-jenkins
#20
(no author information available yet)
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Drug Discovery
journal
journal
39817
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"