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Nature Reviews. Drug Discovery

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https://www.readbyqxmd.com/read/29977053/concerns-challenges-and-promises-of-high-content-analysis-of-3d-cellular-models
#1
Neil Carragher, Filippo Piccinini, Anna Tesei, O Joseph Trask Jr, Marc Bickle, Peter Horvath
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29977052/the-evolution-of-adaptiveness-balancing-speed-and-evidence
#2
Hans-Georg Eichler, Richard Barker, Nicola Bedlington, Jacoline C Bouvy, André W Broekmans, Anna Bucsics, Francesca Cerreta, Solange Corriol-Rohou, Alicia Granados, Yann Le Cam, Ad Schuurman
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29977051/principles-for-targeting-rna-with-drug-like-small-molecules
#3
REVIEW
Katherine Deigan Warner, Christine E Hajdin, Kevin M Weeks
RNA molecules are essential for cellular information transfer and gene regulation, and RNAs have been implicated in many human diseases. Messenger and non-coding RNAs contain highly structured elements, and evidence suggests that many of these structures are important for function. Targeting these RNAs with small molecules offers opportunities to therapeutically modulate numerous cellular processes, including those linked to 'undruggable' protein targets. Despite this promise, there is currently only a single class of human-designed small molecules that target RNA used clinically - the linezolid antibiotics...
July 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29977050/a-call-for-a-global-bigger-data-approach-to-alzheimer-disease
#4
Eric Perakslis, Henry Riordan, Lawrence Friedhoff, Azmi Nabulsi, Emilio Merlo Pich
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29930285/genome-editing-to-re-write-wrongs
#5
Mary Ellen Perry, Kayla M Valdes, Elizabeth Wilder, Christopher P Austin, Philip J Brooks
No abstract text is available yet for this article.
June 22, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29904196/the-promise-and-challenges-of-immune-agonist-antibody-development-in-cancer
#6
REVIEW
Patrick A Mayes, Kenneth W Hance, Axel Hoos
Immune cell functions are regulated by co-inhibitory and co-stimulatory receptors. The first two generations of cancer immunotherapy agents consist primarily of antagonist antibodies that block negative immune checkpoints, such as programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte protein 4 (CTLA4). Looking ahead, there is substantial promise in targeting co-stimulatory receptors with agonist antibodies, and a growing number of these agents are making their way through various stages of development...
June 15, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29904195/infectious-diseases-the-painful-path-to-avoiding-the-immune-system
#7
M Teresa Villanueva
No abstract text is available yet for this article.
June 15, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29904194/the-market-for-oral-anticoagulants
#8
Stephen Bielecki, Dolim Lee, Bashar Hamad
No abstract text is available yet for this article.
June 15, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29904193/cancer-re-educating-tumour-associated-macrophages-with-nanoparticles
#9
Megan Cully
No abstract text is available yet for this article.
June 15, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29904192/stroke-opening-the-therapeutic-window
#10
Sarah Crunkhorn
No abstract text is available yet for this article.
June 15, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29880920/overcoming-the-legal-and-regulatory-barriers-to-drug-repurposing
#11
Alasdair Breckenridge, Robin Jacob
Drug repurposing has been proposed as a strategy to develop new therapies that has fewer risks, lower costs and shorter timelines than developing completely new drugs. However, the potential of this strategy has not been as widely realized as hoped, in part owing to legal and regulatory barriers. Here, we highlight these barriers and consider how they could be overcome.
June 8, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29880919/advances-and-innovations-in-haemophilia-treatment
#12
REVIEW
Rob Peters, Tim Harris
Haemophilia is a rare disease for which the approved therapeutic options have remained virtually unchanged for 50 years. In the past decade, however, there has been an explosion of innovation in the treatment options that are either in development or have been approved for haemophilia, including engineered clotting factors and an extensive pipeline of new approaches and modalities. Several of these new modalities, especially gene therapy, demonstrate proof of principle in haemophilia but could have broader applications...
June 8, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29880918/cryo-em-in-drug-discovery-achievements-limitations-and-prospects
#13
REVIEW
Jean-Paul Renaud, Ashwin Chari, Claudio Ciferri, Wen-Ti Liu, Hervé-William Rémigy, Holger Stark, Christian Wiesmann
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies. Historically, its potential for application in drug discovery has been heavily limited by two issues: the minimum size of the structures it can be used to study and the resolution of the images. However, recent technological advances - including the development of direct electron detectors and more effective computational image analysis techniques - are revolutionizing the utility of cryo-EM, leading to a burst of high-resolution structures of large macromolecular assemblies...
June 8, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29853715/impact-of-the-innovative-medicines-initiative-on-vaccine-development
#14
Philippe Denoel, Patricia Londoño-Hayes, Magda Chlebus, Magdalena Rodriguez de Azero
No abstract text is available yet for this article.
June 1, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29773916/the-haemophilia-drug-market
#15
Kerri Brown, Graeme Green
No abstract text is available yet for this article.
May 18, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29725132/post-exposure-treatments-for-ebola-and-marburg-virus-infections
#16
Robert W Cross, Chad E Mire, Heinz Feldmann, Thomas W Geisbert
This corrects the article DOI: 10.1038/nrd.2017.251.
May 4, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29700501/the-expanding-role-of-prodrugs-in-contemporary-drug-design-and-development
#17
REVIEW
Jarkko Rautio, Nicholas A Meanwell, Li Di, Michael J Hageman
Prodrugs are molecules with little or no pharmacological activity that are converted to the active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two. Prodrugs have evolved from being serendipitously discovered or used as a salvage effort to being intentionally designed. Such efforts can avoid drug development challenges that limit formulation options or result in unacceptable biopharmaceutical or pharmacokinetic performance, or poor targeting. In the past 10 years, the US Food and Drug Administration has approved at least 30 prodrugs, which accounts for more than 12% of all approved small-molecule new chemical entities...
April 27, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29674698/translating-translation
#18
Christopher P Austin
No abstract text is available yet for this article.
April 20, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282375/can-innate-immune-system-targets-turn-up-the-heat-on-cold-tumours
#19
Asher Mullard
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29282372/market-watch-upcoming-market-catalysts-in-q1-2018
#20
Tanner Collins
No abstract text is available yet for this article.
December 28, 2018: Nature Reviews. Drug Discovery
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