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Nature Reviews. Immunology

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https://www.readbyqxmd.com/read/29292394/raging-evolution-of-a-b-cell-response-to-a-viral-infection
#1
Shane Crotty
No abstract text is available yet for this article.
January 2, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29292393/peptidoglycan-recognition-by-the-innate-immune-system
#2
REVIEW
Andrea J Wolf, David M Underhill
The innate immune system recognizes microbial products using germline-encoded receptors that initiate inflammatory responses to infection. The bacterial cell wall component peptidoglycan is a prime example of a conserved pathogen-associated molecular pattern (PAMP) for which the innate immune system has evolved sensing mechanisms. Peptidoglycan is a direct target for innate immune receptors and also regulates the accessibility of other PAMPs to additional innate immune receptors. Subtle structural modifications to peptidoglycan can influence the ability of the innate immune system to detect bacteria and can allow bacteria to evade or alter host defences...
January 2, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29292392/macrophages-and-monocytes-in-2017-macrophages-and-monocytes-of-tortoises-and-hares
#3
Steffen Jung
No abstract text is available yet for this article.
January 2, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29292391/hla-variation-and-disease
#4
REVIEW
Calliope A Dendrou, Jan Petersen, Jamie Rossjohn, Lars Fugger
Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease...
January 2, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29279614/are-histones-real-pathogenic-agents-in-sepsis
#5
Tom van der Poll, Frank L van de Veerdonk, Brendon P Scicluna, Mihai G Netea
No abstract text is available yet for this article.
December 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29279613/the-dawn-of-vaccines-for-cancer-prevention
#6
REVIEW
Olivera J Finn
An important role of the immune system is in the surveillance for abnormal or transformed cells, which is known as cancer immunosurveillance. Through this process, the first changes to normal tissue homeostasis caused by infectious or other inflammatory insults can be detected by the immune system through the recognition of antigenic molecules (including tumour antigens) expressed by abnormal cells. However, as they develop, tumour cells can acquire antigenic and other changes that allow them to escape elimination by the immune system...
December 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29279612/are-histones-real-pathogenic-agents-in-sepsis
#7
Isaac Ginsburg, Erez Koren
No abstract text is available yet for this article.
December 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29279611/immunotherapy-hla-genotype-good-to-be-different
#8
Kirsty Minton
No abstract text is available yet for this article.
December 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29279610/neuroimmunology-in-2017-the-central-nervous-system-privileged-by-immune-connections
#9
Jonathan Kipnis, Anthony J Filiano
No abstract text is available yet for this article.
December 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29249807/viral-subversion-of-b-cell-responses-within-secondary-lymphoid-organs
#10
REVIEW
Mirela Kuka, Matteo Iannacone
Antibodies play a crucial role in virus control. The production of antibodies requires virus-specific B cells to encounter viral antigens in lymph nodes, become activated, interact with different immune cells, proliferate and enter specific differentiation programmes. Each step occurs in distinct lymph node niches, requiring a coordinated migration of B cells between different subcompartments. The development of multiphoton intravital microscopy has enabled researchers to begin to elucidate the precise cellular and molecular events by which lymph nodes coordinate humoral responses...
December 18, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29226912/innate-immunity-platelets-on-the-prowl
#11
Yvonne Bordon
No abstract text is available yet for this article.
December 11, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29226911/immunometabolism-in-2017-driving-immunity-all-roads-lead-to-metabolism
#12
Edward J Pearce, Erika L Pearce
No abstract text is available yet for this article.
December 11, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29226910/towards-personalized-tumour-specific-therapeutic-vaccines-for-cancer
#13
REVIEW
Zhuting Hu, Patrick A Ott, Catherine J Wu
Cancer vaccines, which are designed to amplify tumour-specific T cell responses through active immunization, have long been envisioned as a key tool of effective cancer immunotherapy. Despite a clear rationale for such vaccines, extensive past efforts were unsuccessful in mediating clinically relevant antitumour activity in humans. Recently, however, next-generation sequencing and novel bioinformatics tools have enabled the systematic discovery of tumour neoantigens, which are highly desirable immunogens because they arise from somatic mutations of the tumour and are therefore tumour specific...
December 11, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29199280/vaccines-in-2017-closing-in-on-a-zika-virus-vaccine
#14
Michael S Diamond, Carolyn B Coyne
No abstract text is available yet for this article.
December 4, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29199279/chemokines-moving-on-up
#15
Kirsty Minton
No abstract text is available yet for this article.
December 4, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29176731/itims-episode-1-of-the-inhibitory-saga
#16
Eric Vivier
No abstract text is available yet for this article.
November 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29151590/microglia-and-macrophages-in-brain-homeostasis-and-disease
#17
REVIEW
Qingyun Li, Ben A Barres
Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that are increasingly recognized to be essential players in the development, homeostasis and diseases of the central nervous system. With the availability of new genetic, molecular and pharmacological tools, considerable advances have been made towards our understanding of the embryonic origins, developmental programmes and functions of these cells. These exciting discoveries, some of which are still controversial, also raise many new questions, which makes brain macrophage biology a fast-growing field at the intersection of neuroscience and immunology...
November 20, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29129915/mhc-molecules-immune-editing-shapes-the-cancer-landscape
#18
Shimona Starling
No abstract text is available yet for this article.
November 13, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29129914/dendritic-cells-managing-migration
#19
Kirsty Minton
No abstract text is available yet for this article.
November 13, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28990585/the-diverse-functions-of-the-pd1-inhibitory-pathway
#20
REVIEW
Arlene H Sharpe, Kristen E Pauken
T cell activation is a highly regulated process involving peptide-MHC engagement of the T cell receptor and positive costimulatory signals. Upon activation, coinhibitory 'checkpoints', including programmed cell death protein 1 (PD1), become induced to regulate T cells. PD1 has an essential role in balancing protective immunity and immunopathology, homeostasis and tolerance. However, during responses to chronic pathogens and tumours, PD1 expression can limit protective immunity. Recently developed PD1 pathway inhibitors have revolutionized cancer treatment for some patients, but the majority of patients do not show complete responses, and adverse events have been noted...
November 13, 2017: Nature Reviews. Immunology
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