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Nature Reviews. Immunology

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https://www.readbyqxmd.com/read/29760508/reigning-in-rig-i
#1
Lucy Bird
No abstract text is available yet for this article.
May 14, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29752467/lc3-anchors-tlr9-signalling
#2
Kirsty Minton
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29743717/integrating-oncolytic-viruses-in-combination-cancer-immunotherapy
#3
REVIEW
Praveen K Bommareddy, Megha Shettigar, Howard L Kaufman
Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer-immunity cycle. Oncolytic viruses directly lyse tumour cells, leading to the release of soluble antigens, danger signals and type I interferons, which drive antitumour immunity. In addition, some oncolytic viruses can be engineered to express therapeutic genes or can functionally alter tumour-associated endothelial cells, further enhancing T cell recruitment into immune-excluded or immune-deserted tumour microenvironments...
May 9, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29725119/itaconate-charges-down-inflammation
#4
Yvonne Bordon
No abstract text is available yet for this article.
May 3, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29725118/%C3%AE-%C3%AE-t-cells-turn-up-the-heat
#5
Grant Otto
No abstract text is available yet for this article.
May 3, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29717233/diverse-developmental-pathways-of-intestinal-intraepithelial-lymphocytes
#6
REVIEW
Benjamin D McDonald, Bana Jabri, Albert Bendelac
The intestinal epithelial barrier is patrolled by resident intraepithelial lymphocytes (IELs) that are involved in host defence against pathogens, wound repair and homeostatic interactions with the epithelium, microbiota and nutrients. Intestinal IELs are one of the largest populations of lymphocytes in the body and comprise several distinct subsets, the identity and lineage relationships of which have long remained elusive. Here, we review advances in unravelling the complexity of intestinal IEL populations, which comprise conventional αβ T cell receptor (TCRαβ)+ subsets, unconventional TCRαβ+ and TCRγδ+ subsets, group 1 innate lymphoid cells (ILC1s) and ILC1-like cells...
May 1, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29713017/microglial-memory
#7
Lucy Bird
No abstract text is available yet for this article.
April 30, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29691474/viral-tropism-for-tuft-cells
#8
Kirsty Minton
No abstract text is available yet for this article.
April 24, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29691473/the-ifn-road-not-taken
#9
Yvonne Bordon
No abstract text is available yet for this article.
April 24, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29674650/specificity-for-hcmv-strains
#10
Kirsty Minton
No abstract text is available yet for this article.
April 19, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29662121/clocking-in-to-immunity
#11
REVIEW
Christoph Scheiermann, Julie Gibbs, Louise Ince, Andrew Loudon
Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide diversity of physiological systems. It has long been established that the circadian clockwork plays a key role in innate immune responses, and recent studies reveal that several aspects of adaptive immunity are also under circadian control. We discuss the latest insights into the genetic and biochemical mechanisms linking immunity to the core circadian clock of the cell and hypothesize as to why the immune system is so tightly controlled by circadian oscillations...
April 16, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29662120/an-early-history-of-t-cell-mediated-cytotoxicity
#12
REVIEW
Pierre Golstein, Gillian M Griffiths
After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have gained a detailed knowledge of the cells involved, specific recognition mechanisms and post-recognition perforin-granzyme-based and FAS-based molecular mechanisms. What could not be anticipated at the outset was how discovery of the mechanisms regulating the activation and function of cytotoxic T cells would lead to new developments in cancer immunotherapy. Given the profound recent interest in therapeutic manipulation of cytotoxic T cell responses, it is an opportune time to look back on the early history of the field...
April 16, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29658511/immunometabolism-old-drug-new-trick
#13
Yvonne Bordon
No abstract text is available yet for this article.
April 16, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29636542/understanding-the-drivers-of-mhc-restriction-of-t-cell-receptors
#14
REVIEW
Nicole L La Gruta, Stephanie Gras, Stephen R Daley, Paul G Thomas, Jamie Rossjohn
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-recognition of peptides presented by MHC molecules. Over the past 20 years, structurally focused investigations into this MHC-restricted response have provided profound insights into T cell function. Simultaneously, two models of TCR recognition have emerged, centred on whether the TCR has, through evolution, acquired an intrinsic germline-encoded capacity for MHC recognition or whether MHC reactivity is conferred by developmental selection of TCRs...
April 10, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29629714/discovering-transcriptional-signatures-of-disease-for-diagnosis-versus-mechanism
#15
Julie G Burel, Bjoern Peters
No abstract text is available yet for this article.
April 9, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29629713/immunometabolism-itaconate-helps-keap1-s-cool
#16
Grant Otto
No abstract text is available yet for this article.
April 9, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29626211/targeting-cytokines-to-treat-asthma-and-chronic-obstructive-pulmonary-disease
#17
REVIEW
Peter J Barnes
Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation in asthma and chronic obstructive pulmonary disease (COPD), making them attractive targets for treating these disorders. Asthma and some cases of COPD are mainly driven by type 2 immune responses, which comprise increased airway eosinophils, T helper 2 (TH 2) cells and group 2 innate lymphoid cells (ILC2s) and the secretion of IL-4, IL-5 and IL-13. Clinical trials of antibodies that block these interleukins have shown reduced acute exacerbations and oral corticosteroid use and improvements in lung function and symptoms in selected patients...
April 6, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29616685/germinal-centres-an-exit-strategy-for-b-cells
#18
Kirsty Minton
No abstract text is available yet for this article.
April 4, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29616684/allergy-an-alarmin-cut
#19
Lucy Bird
No abstract text is available yet for this article.
April 4, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29616683/macrophages-running-on-empty
#20
Yvonne Bordon
No abstract text is available yet for this article.
April 4, 2018: Nature Reviews. Immunology
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