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Nature Reviews. Immunology

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https://www.readbyqxmd.com/read/28216614/infection-il-22-controls-iron-scavenging
#1
Elisabeth Kugelberg
No abstract text is available yet for this article.
February 20, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28216613/infectious-disease-hitching-a-ride-with-dcs
#2
Yvonne Bordon
No abstract text is available yet for this article.
February 20, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28216612/macrophages-mtorc1-drives-granulomas
#3
Lucy Bird
No abstract text is available yet for this article.
February 20, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28192416/mucosal-immunology-rationing-ahr-ligands
#4
Kirsty Minton
No abstract text is available yet for this article.
February 13, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28192415/immune-regulation-by-glucocorticoids
#5
REVIEW
Derek W Cain, John A Cidlowski
Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive...
February 13, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28163303/regulation-of-muscle-growth-and-regeneration-by-the-immune-system
#6
REVIEW
James G Tidball
Diseases of muscle that are caused by pathological interactions between muscle and the immune system are devastating, but rare. However, muscle injuries that involve trauma and regeneration are fairly common, and inflammation is a clear feature of the regenerative process. Investigations of the inflammatory response to muscle injury have now revealed that the apparently nonspecific inflammatory response to trauma is actually a complex and coordinated interaction between muscle and the immune system that determines the success or failure of tissue regeneration...
February 6, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28163302/programmed-cell-death-and-the-immune-system
#7
REVIEW
Shigekazu Nagata, Masato Tanaka
More than 50 years ago, cells were observed to die during insect development via a process that was named 'programmed cell death'. Later, a similar cell death process was found to occur in humans, and the process was renamed 'apoptosis'. In the 1990s, a number of apoptosis-regulating molecules were identified, and apoptosis was found to have essential roles in the immune system. In this Timeline article, we highlight the key events that have demonstrated the importance of programmed cell death processes, including apoptosis and programmed necrosis, in the immune system...
February 6, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28163301/homeostasis-altering-molecular-processes-as-mechanisms-of-inflammasome-activation
#8
REVIEW
Adrian Liston, Seth L Masters
The innate immune system uses a distinct set of germline-encoded pattern recognition receptors (PRRs) to initiate downstream inflammatory cascades. This recognition system is in stark contrast to the adaptive immune system, which relies on highly variable, randomly generated antigen receptors. A key limitation of the innate immune system's reliance on fixed PRRs is its inflexibility in responding to rapidly evolving pathogens. Recent advances in our understanding of inflammasome activation suggest that the innate immune system also has sophisticated mechanisms for responding to pathogens for which there is no fixed PRR...
February 6, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28138138/multi-dimensional-control-of-clonal-evolution
#9
Michael McHeyzer-Williams
No abstract text is available yet for this article.
January 31, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28138137/programmed-cell-death-as-a-defence-against-infection
#10
REVIEW
Ine Jorgensen, Manira Rayamajhi, Edward A Miao
Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and viral infection: apoptosis, necroptosis, pyroptosis and NETosis. We describe the interactions that interweave different programmed cell death pathways, which create complex signalling networks that cross-guard each other in the evolutionary 'arms race' with pathogens...
January 31, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28138136/t-cell-responses-in-the-central-nervous-system
#11
REVIEW
Thomas Korn, Axel Kallies
T cells are required for immune surveillance of the central nervous system (CNS); however, they can also induce severe immunopathology in the context of both viral infections and autoimmunity. The mechanisms that are involved in the priming and recruitment of T cells to the CNS are only partially understood, but there has been renewed interest in this topic since the 'rediscovery' of lymphatic drainage from the CNS. Moreover, tissue-resident memory T cells have been detected in the CNS and are increasingly recognized as an autonomous line of host defence...
January 31, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28111476/antibody-responses-a-thymic-niche-for-plasma-cells
#12
Yvonne Bordon
No abstract text is available yet for this article.
January 23, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28111475/immunobiology-of-ebola-and-lassa-virus-infections
#13
REVIEW
Joseph B Prescott, Andrea Marzi, David Safronetz, Shelly J Robertson, Heinz Feldmann, Sonja M Best
Two of the most important contemporary emerging viruses that affect human health in Africa are Ebola virus (EBOV) and Lassa virus (LASV). The 2013-2016 West African outbreak of EBOV was responsible for more than 11,000 deaths, primarily in Guinea, Sierra Leone and Liberia. LASV is constantly emerging in these and surrounding West African countries, with an estimate of more than 500,000 cases of Lassa fever, and approximately 5,000 deaths, annually. Both EBOV and LASV are zoonotic, and human infection often results in a severe haemorrhagic fever in both cases...
January 23, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28111474/inflammation-inflammasome-related-ageing
#14
Kirsty Minton
No abstract text is available yet for this article.
January 23, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28044058/allergy-neonatal-il-33-drives-allergy
#15
Lydia Shipman
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28044056/tumour-immunology-nlrc3-inhibits-mtor-in-colorectal-cancer
#16
Olive Leavy
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28044055/immunometabolism-complex-metabolic-responses-to-microbial-stimuli
#17
Elisabeth Kugelberg
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28028312/reply-the-complement-system-is-also-important-in-immunogenic-cell-death
#18
Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel, Guido Kroemer
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28028311/the-complement-system-is-also-important-in-immunogenic-cell-death
#19
Junfei Jin, Songqing He
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28138142/autoimmune-diseases-inhibitor-of-adaptor-protein-shows-self-antigen-selectivity
#20
Alexandra Flemming
No abstract text is available yet for this article.
January 31, 2017: Nature Reviews. Immunology
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