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Nature Reviews. Immunology

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https://www.readbyqxmd.com/read/28044058/allergy-neonatal-il-33-drives-allergy
#1
Lydia Shipman
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28044057/disease-tolerance-and-immunity-in-host-protection-against-infection
#2
Miguel P Soares, Luis Teixeira, Luis F Moita
The immune system probably evolved to limit the negative effects exerted by pathogens on host homeostasis. This defence strategy relies on the concerted action of innate and adaptive components of the immune system, which sense and target pathogens for containment, destruction or expulsion. Resistance to infection refers to these immune functions, which reduce the pathogen load of an infected host as the means to preserve homeostasis. Immune-driven resistance to infection is coupled to an additional, and arguably as important, defence strategy that limits the extent of dysfunction imposed on host parenchymal tissues during infection, without exerting a direct negative effect on pathogens...
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28044056/tumour-immunology-nlrc3-inhibits-mtor-in-colorectal-cancer
#3
Olive Leavy
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28044055/immunometabolism-complex-metabolic-responses-to-microbial-stimuli
#4
Elisabeth Kugelberg
No abstract text is available yet for this article.
January 3, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28028312/reply-the-complement-system-is-also-important-in-immunogenic-cell-death
#5
Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel, Guido Kroemer
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28028311/the-complement-system-is-also-important-in-immunogenic-cell-death
#6
Junfei Jin, Songqing He
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28028310/mechanisms-of-immunomodulation-by-mammalian-and-viral-decoy-receptors-insights-from-structures
#7
Jan Felix, Savvas N Savvides
Immune responses are regulated by effector cytokines and chemokines that signal through cell surface receptors. Mammalian decoy receptors - which are typically soluble or inactive versions of cell surface receptors or soluble protein modules termed binding proteins - modulate and antagonize signalling by canonical effector-receptor complexes. Viruses have developed a diverse array of molecular decoys to evade host immune responses; these include viral homologues of host cytokines, chemokines and chemokine receptors; variants of host receptors with new functions; and novel decoy receptors that do not have host counterparts...
December 28, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27990022/rna-binding-proteins-in-immune-regulation-a-focus-on-ccch-zinc-finger-proteins
#8
Mingui Fu, Perry J Blackshear
Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1 and MCPIP1 (also known as regnase 1), are crucial for many aspects of immune regulation by targeting mRNAs for degradation and modulation of signalling pathways. In this Review, we focus on the emerging roles of CCCH zinc finger proteins in the regulation of immune responses through their effects on cytokine production, immune cell activation and immune homeostasis...
December 19, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27841281/a-third-signal-from-conditioned-dcs-dictates-microbial-effector-choice
#9
Alan Sher
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27841280/macrophages-shaping-good-eating-habits
#10
Yvonne Bordon
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27818504/do-antibodies-select-a-healthy-microbiota
#11
Jason L Kubinak, June L Round
Disruptions to the microbiota can have pathological consequences, which highlights the need to understand the factors that contribute to its stability. Although decades of research have focused on the importance of IgA during pathogenic infection, much of the IgA that is generated in the gut targets the resident commensal microorganisms. Despite this observation, the role of antibodies in regulating microbiota composition remains controversial and poorly understood. Here we propose that antibodies generated in response to microbial colonization of the gut shape the composition of the microbiota to benefit the health of the host through a process that we term antibody-mediated immunoselection (AMIS)...
November 7, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27818503/prime-boost-strategies-to-embrace-diversity-and-inclusion-in-immunology
#12
Cherie L Butts, Irelene P Ricks, Avery August
Immunologists appreciate the need for creative approaches to tackle complex scientific questions, which can involve not only the use of novel technologies but also the experience of scientists from diverse backgrounds. Here, we highlight measures to prime for the inclusion of women and underrepresented individuals in science to boost immunology research.
November 7, 2016: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27941892/allergy-pollutants-drive-atopic-dermatitis
#13
Yvonne Bordon
No abstract text is available yet for this article.
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27941891/haematopoiesis-hsc-function-determined-by-epigenetic-memory
#14
Kirsty Minton
No abstract text is available yet for this article.
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27941890/infection-tslp-complements-neutrophil-killing-of-bacteria
#15
Elisabeth Kugelberg
No abstract text is available yet for this article.
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27916981/tumour-immunology-interrogating-intratumoral-treg-cells
#16
Lydia Shipman
No abstract text is available yet for this article.
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27916980/the-immunopathogenesis-of-seropositive-rheumatoid-arthritis-from-triggering-to-targeting
#17
Vivianne Malmström, Anca I Catrina, Lars Klareskog
Patients with rheumatoid arthritis can be divided into two major subsets characterized by the presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of rheumatoid factor (RF). The antibody-positive subset of disease, also known as seropositive rheumatoid arthritis, constitutes approximately two-thirds of all cases of rheumatoid arthritis and generally has a more severe disease course. ACPAs and RF are often present in the blood long before any signs of joint inflammation, which suggests that the triggering of autoimmunity may occur at sites other than the joints (for example, in the lung)...
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27916979/cytokine-networks-in-neuroinflammation
#18
Burkhard Becher, Sabine Spath, Joan Goverman
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The central nervous system (CNS), where few blood-borne immune cells circulate, seems to be particularly vulnerable to dysregulated cytokine networks. In degenerative diseases, such as proteopathies, CNS-resident cells are the predominant producers of pro-inflammatory cytokines...
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27916978/correlates-of-protection-against-neisseria-meningitidis
#19
Andrew Pollard
No abstract text is available yet for this article.
January 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/27916977/human-immune-system-variation
#20
Petter Brodin, Mark M Davis
The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's immune system is now becoming clearer. Human immune systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation...
January 2017: Nature Reviews. Immunology
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