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Nature Reviews. Immunology

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https://www.readbyqxmd.com/read/30022149/histone-deacetylase-function-in-cd4-t-cells
#1
REVIEW
Wilfried Ellmeier, Christian Seiser
The differentiation of T helper cell subsets and their acquisition of effector functions are accompanied by changes in gene expression programmes, which in part are regulated and maintained by epigenetic processes. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are key epigenetic regulators that function by mediating dynamic changes in the acetylation of histones at lysine residues. In addition, many non-histone proteins are also acetylated, and reversible acetylation affects their functional properties, demonstrating that HDACs mediate effects beyond the epigenetic regulation of gene expression...
July 18, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/30018454/chance-favours-the-prepared-mind
#2
Jeffrey A Bluestone
No abstract text is available yet for this article.
July 17, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/30006523/quorum-sensing-in-the-immune-system
#3
Luca Antonioli, Corrado Blandizzi, Pál Pacher, Martin Guilliams, György Haskó
No abstract text is available yet for this article.
July 13, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29991741/p2rx7-keeps-memory-t-cells-fit
#4
Yvonne Bordon
No abstract text is available yet for this article.
July 10, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29985485/tumour-decides-immune-cell-ins-and-outs
#5
Grant Otto
No abstract text is available yet for this article.
July 9, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29980740/rfx7-keeps-killers-quiescent
#6
Lucy Bird
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29970907/neuroendocrine-cells-amplify-asthma
#7
Lucy Bird
No abstract text is available yet for this article.
July 3, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29967365/tissue-specific-functions-of-invariant-natural-killer-t-cells
#8
REVIEW
Catherine M Crosby, Mitchell Kronenberg
Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They secrete diverse cytokines and can influence many types of immune responses. Despite having highly similar TCR specificities, iNKT cells differentiate in the thymus into distinct subsets that are analogous to T helper 1 (TH 1), TH 2 and TH 17 cell subsets. Additional iNKT cell subsets that may require peripheral activation have also been described, including one that produces IL-10...
July 2, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29950609/viperin-breaks-viral-chains
#9
Kirsty Minton
No abstract text is available yet for this article.
June 27, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29946075/t-h-9-cells-tackle-advanced-tumours
#10
Alexandra Flemming
No abstract text is available yet for this article.
June 26, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29934605/publisher-correction-to-respond-or-not-to-respond-a-personal-perspective-of-intestinal-tolerance
#11
Allan McI Mowat
In the originally published article, several references referring to the Timeline figure were missing or incorrect. This mistake has now been corrected and the publisher apologizes for this error.
June 22, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29930315/author-correction-integrating-oncolytic-viruses-in-combination-cancer-immunotherapy
#12
Praveen K Bommareddy, Megha Shettigar, Howard L Kaufman
In the initially published version of this article online in advance of print, a reference (Ajina, A. & Maher, J. Prospects for combined use of oncolytic viruses and CAR T-cells. J. Immunother. Cancer 5, 90 (2017)) was omitted in error from the following sentence: "The ability of oncolytic viruses to increase the expression of MHC class I molecules by cancer cells is also predicted to enhance ACT with TILs or TCR-engineered and chimeric antigen receptor (CAR) T cells that target tumour-specific antigens"...
June 21, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29921905/ifn%C3%AE-signalling-epigenetics-and-roles-in-immunity-metabolism-disease-and-cancer-immunotherapy
#13
REVIEW
Lionel B Ivashkiv
IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions. This Review focuses on recent advances in our understanding of the transcriptional, chromatin-based and metabolic mechanisms that underlie IFNγ-mediated polarization of macrophages to an 'M1-like' state, which is characterized by increased pro-inflammatory activity and macrophage resistance to tolerogenic and anti-inflammatory factors...
June 19, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29899366/calming-the-cytokine-storm
#14
Lucy Bird
No abstract text is available yet for this article.
June 13, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29895826/immunological-mechanisms-of-human-resistance-to-persistent-mycobacterium-tuberculosis-infection
#15
REVIEW
Jason D Simmons, Catherine M Stein, Chetan Seshadri, Monica Campo, Galit Alter, Sarah Fortune, Erwin Schurr, Robert S Wallis, Gavin Churchyard, Harriet Mayanja-Kizza, W Henry Boom, Thomas R Hawn
Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a long-lived latent infection in a substantial proportion of the human population. Multiple lines of evidence suggest that some individuals are resistant to latent M. tuberculosis infection despite long-term and intense exposure, and we term these individuals 'resisters'. In this Review, we discuss the epidemiological and genetic data that support the existence of resisters and propose criteria to optimally define and characterize the resister phenotype...
June 12, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29872140/antibodies-and-tuberculosis-finally-coming-of-age
#16
REVIEW
Hao Li, Babak Javid
Are antibodies important for protection against tuberculosis? The jury has been out for more than 100 years. B cell depletion in experimental Mycobacterium tuberculosis infection failed to identify a major role for these cells in immunity to tuberculosis. However, recent identification of naturally occurring antibodies in humans that are protective during M. tuberculosis infection has reignited the debate. Here, we discuss the evidence for a protective role for antibodies in tuberculosis and consider the feasibility of designing novel tuberculosis vaccines targeting humoral immunity...
June 5, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29858587/the-inflammasome-starts-rolling
#17
Thirumala-Devi Kanneganti
No abstract text is available yet for this article.
June 1, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29789755/regulatory-mechanisms-in-t-cell-receptor-signalling
#18
REVIEW
Guillaume Gaud, Renaud Lesourne, Paul E Love
The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR signals elicit such diverse cellular responses and outcomes remains a major question for investigation. Recent years have witnessed important advances in our understanding of the regulatory processes that control and modulate the TCR signalling response. Here, we review newly identified mechanisms for the regulation of TCR signalling and then discuss how the TCR signalling response is regulated to control two critical cellular processes - namely, positive selection and T cell homeostasis...
May 22, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29752467/lc3-anchors-tlr9-signalling
#19
Kirsty Minton
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29743717/integrating-oncolytic-viruses-in-combination-cancer-immunotherapy
#20
REVIEW
Praveen K Bommareddy, Megha Shettigar, Howard L Kaufman
Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer-immunity cycle. Oncolytic viruses directly lyse tumour cells, leading to the release of soluble antigens, danger signals and type I interferons, which drive antitumour immunity. In addition, some oncolytic viruses can be engineered to express therapeutic genes or can functionally alter tumour-associated endothelial cells, further enhancing T cell recruitment into immune-excluded or immune-deserted tumour microenvironments...
May 9, 2018: Nature Reviews. Immunology
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