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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/28798486/tumour-evolution-metastasis-takes-a-different-route
#1
Anna Dart
No abstract text is available yet for this article.
August 11, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28798485/therapeutic-resistance-ironing-it-out
#2
Ulrike Harjes
No abstract text is available yet for this article.
August 11, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28751651/targeting-autophagy-in-cancer
#3
REVIEW
Jean M Mulcahy Levy, Christina G Towers, Andrew Thorburn
Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design...
July 28, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642602/tumour-immunology-lap-targeting-reduces-tolerogenic-cells-in-cancer
#4
Alexandra Flemming
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28706266/microenvironmental-regulation-of-tumour-angiogenesis
#5
REVIEW
Michele De Palma, Daniela Biziato, Tatiana V Petrova
Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles. In this Review, we discuss the extrinsic regulation of angiogenesis by the tumour microenvironment, highlighting potential vulnerabilities that could be targeted to improve the applicability and reach of anti-angiogenic cancer therapies...
August 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28706265/epigenetics-therapy-induced-transcription-is-cryptically-widespread
#6
Darren J Burgess
No abstract text is available yet for this article.
August 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28684877/immunotherapy-keeping-breast-cancer-in-check
#7
Liesbet Lieben
No abstract text is available yet for this article.
August 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28663589/pancreatic-cancer-iexosomes-target-the-undruggable
#8
Conor A Bradley
No abstract text is available yet for this article.
August 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28643779/drugging-the-undruggable-cancer-targets
#9
REVIEW
Chi V Dang, E Premkumar Reddy, Kevan M Shokat, Laura Soucek
The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these targets, and therefore more appropriate terms might be 'difficult to drug' or 'yet to be drugged'. Many desirable targets in cancer fall into this category, including the RAS and MYC oncogenes, and pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new technologies...
August 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740119/novel-insights-into-mesothelioma-biology-and-implications-for-therapy
#10
REVIEW
Timothy A Yap, Joachim G Aerts, Sanjay Popat, Dean A Fennell
Malignant mesothelioma is a universally lethal cancer that is increasing in incidence worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and cisplatin combination chemotherapy) approved in the past 13 years. However, the past 5 years have witnessed an exponential growth in our understanding of mesothelioma pathobiology, which is set to revolutionize therapeutic strategies. From a genomic standpoint, mesothelioma is characterized by a preponderance of tumour suppressor alterations, for which novel therapies are currently in development...
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740118/leukaemia-multiple-origins-of-relapse
#11
Ulrike Harjes
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740117/fragile-sites-in-cancer-more-than-meets-the-eye
#12
REVIEW
Thomas W Glover, Thomas E Wilson, Martin F Arlt
Ever since initial suggestions that instability at common fragile sites (CFSs) could be responsible for chromosome rearrangements in cancers, CFSs and associated genes have been the subject of numerous studies, leading to questions and controversies about their role and importance in cancer. It is now clear that CFSs are not frequently involved in translocations or other cancer-associated recurrent gross chromosome rearrangements. However, recent studies have provided new insights into the mechanisms of CFS instability, their effect on genome instability, and their role in generating focal copy number alterations that affect the genomic landscape of many cancers...
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740116/tumour-immunology-feeding-frenzy
#13
Anna Dart
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740115/chemotherapy-neutrophils-deliver-the-goods
#14
M Teresa Villanueva
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740114/tumour-vaccines-personal-training-by-vaccination
#15
Ulrike Harjes
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740113/tumour-immunology-tumours-copy-to-escape
#16
Ulrike Harjes
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740112/epigenetics-tumour-suppressive-hif2%C3%AE
#17
Anna Dart
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740111/therapeutic-resistance-transcribing-patterns-of-resistance
#18
Sarah Seton-Rogers
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28740110/neuroblastoma-tumours-get-super-enhanced
#19
Conor A Bradley
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642605/immunotherapy-macrophages-steal-the-show
#20
M Teresa Villanueva
No abstract text is available yet for this article.
July 23, 2017: Nature Reviews. Cancer
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