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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/28450705/the-ets-family-of-oncogenic-transcription-factors-in-solid-tumours
#1
REVIEW
Gina M Sizemore, Jason R Pitarresi, Subhasree Balakrishnan, Michael C Ostrowski
Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth factor signalling loops, formation of gain-of-function co-regulatory complexes and novel cis-acting mutations in ETS target gene promoters can result in increased ETS activity. In turn, pro-oncogenic ETS signalling enhances tumorigenesis through a broad mechanistic toolbox that includes lineage specification and self-renewal, DNA damage and genome instability, epigenetics and metabolism...
April 28, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28450704/melanoma-a-global-perspective
#2
Raul Ossio, Rodrigo Roldán-Marín, Héctor Martínez-Said, David J Adams, Carla Daniela Robles-Espinoza
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28416802/rna-editing-dependent-epitranscriptome-diversity-in-cancer-stem-cells
#3
REVIEW
Qingfei Jiang, Leslie A Crews, Frida Holm, Catriona H M Jamieson
Cancer stem cells (CSCs) can regenerate all facets of a tumour as a result of their stem cell-like capacity to self-renew, survive and become dormant in protective microenvironments. CSCs evolve during tumour progression in a manner that conforms to Charles Darwin's principle of natural selection. Although somatic DNA mutations and epigenetic alterations promote evolution, post-transcriptional RNA modifications together with RNA binding protein activity (the 'epitranscriptome') might also contribute to clonal evolution through dynamic determination of RNA function and gene expression diversity in response to environmental stimuli...
April 18, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28386091/the-calcium-cancer-signalling-nexus
#4
REVIEW
Gregory R Monteith, Natalia Prevarskaya, Sarah J Roberts-Thomson
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past decade there has been a deeper understanding of how calcium signalling is remodelled in some cancers and the consequences of calcium signalling on key events such as proliferation, invasion and sensitivity to cell death...
April 7, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28280269/cancer-therapy-induced-pafr-ligand-expression-any-role-for-caspase-activity
#5
Gabriel Ichim, Stephen W G Tait
No abstract text is available yet for this article.
March 10, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28280268/oncogenic-effects-of-pafr-ligands-produced-in-tumours-upon-chemotherapy-and-radiotherapy
#6
Roger Chammas, Luciana Nogueira de Sousa Andrade, Sonia Jancar
No abstract text is available yet for this article.
March 10, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28386090/metastasis-breaching-barriers
#7
Anna Dart
No abstract text is available yet for this article.
May 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28338065/prospects-for-combining-targeted-and-conventional-cancer-therapy-with-immunotherapy
#8
REVIEW
Philip Gotwals, Scott Cameron, Daniela Cipolletta, Viviana Cremasco, Adam Crystal, Becker Hewes, Britta Mueller, Sonia Quaratino, Catherine Sabatos-Peyton, Lilli Petruzzelli, Jeffrey A Engelman, Glenn Dranoff
Over the past 25 years, research in cancer therapeutics has largely focused on two distinct lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous, genetic drivers of tumorigenesis have led to the development of clinically important targeted agents that result in profound, but often not durable, tumour responses in genetically defined patient populations. In the second parallel approach, exploration of the mechanisms of protective tumour immunity has provided several therapeutic strategies - most notably the 'immune checkpoint' antibodies that reverse the negative regulators of T cell function - that accomplish durable clinical responses in subsets of patients with various tumour types...
May 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28303906/advances-and-challenges-in-targeting-fgfr-signalling-in-cancer
#9
REVIEW
Irina S Babina, Nicholas C Turner
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed results with FGFR-targeted cancer therapies, revealing substantial complexity to targeting aberrant FGFR signalling. In this Review, we discuss the increasing understanding of the differences between diverse mechanisms of oncogenic activation of FGFR, and the factors that determine response and resistance to FGFR targeting...
May 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28303905/pre-metastatic-niches-organ-specific-homes-for-metastases
#10
REVIEW
Héctor Peinado, Haiying Zhang, Irina R Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra N Kaplan, Jacqueline F Bromberg, Yibin Kang, Mina J Bissell, Thomas R Cox, Amato J Giaccia, Janine T Erler, Sachie Hiratsuka, Cyrus M Ghajar, David Lyden
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche...
May 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28303904/microbiota-a-key-orchestrator-of-cancer-therapy
#11
REVIEW
Soumen Roy, Giorgio Trinchieri
The microbiota is composed of commensal bacteria and other microorganisms that live on the epithelial barriers of the host. The commensal microbiota is important for the health and survival of the organism. Microbiota influences physiological functions from the maintenance of barrier homeostasis locally to the regulation of metabolism, haematopoiesis, inflammation, immunity and other functions systemically. The microbiota is also involved in the initiation, progression and dissemination of cancer both at epithelial barriers and in sterile tissues...
May 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28436472/leukaemia-gimme-shelter
#12
Nicola McCarthy
No abstract text is available yet for this article.
April 24, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28436471/tumour-suppressors-following-the-clues-of-cancer-resistant-tissues
#13
Sarah Seton-Rogers
No abstract text is available yet for this article.
April 24, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28436470/new-frontiers-in-translational-control-of-the-cancer-genome
#14
Morgan L Truitt, Davide Ruggero
No abstract text is available yet for this article.
April 24, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28280267/cell-migration-shall-we-travel-together
#15
Anna Dart
No abstract text is available yet for this article.
April 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28280266/genomics-a-different-view-of-the-landscape
#16
Sarah Seton-Rogers
No abstract text is available yet for this article.
April 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28256575/immunotherapy-engineered-t-cells-for-all
#17
Gemma K Alderton
No abstract text is available yet for this article.
April 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28256574/tissue-specific-tumorigenesis-context-matters
#18
REVIEW
Günter Schneider, Marc Schmidt-Supprian, Roland Rad, Dieter Saur
How can we treat cancer more effectively? Traditionally, tumours from the same anatomical site are treated as one tumour entity. This concept has been challenged by recent breakthroughs in cancer genomics and translational research that have enabled molecular tumour profiling. The identification and validation of cancer drivers that are shared between different tumour types, spurred the new paradigm to target driver pathways across anatomical sites by off-label drug use, or within so-called basket or umbrella trials which are designed to test whether molecular alterations in one tumour entity can be extrapolated to all others...
April 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28233803/liquid-biopsies-come-of-age-towards-implementation-of-circulating-tumour-dna
#19
REVIEW
Jonathan C M Wan, Charles Massie, Javier Garcia-Corbacho, Florent Mouliere, James D Brenton, Carlos Caldas, Simon Pacey, Richard Baird, Nitzan Rosenfeld
Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and monitoring. The field is now in an exciting transitional period in which ctDNA analysis is beginning to be applied clinically, although there is still much to learn about the biology of cell-free DNA...
April 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28233802/targeting-neoantigens-to-augment-antitumour-immunity
#20
REVIEW
Mark Yarchoan, Burles A Johnson, Eric R Lutz, Daniel A Laheru, Elizabeth M Jaffee
The past decade of cancer research has been marked by a growing appreciation of the role of immunity in cancer. Mutations in the tumour genome can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (neoantigens). These neoantigens are an attractive immune target because their selective expression on tumours may minimize immune tolerance as well as the risk of autoimmunity. In this Review we discuss the emerging evidence that neoantigens are recognized by the immune system and can be targeted to increase antitumour immunity...
April 2017: Nature Reviews. Cancer
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