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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/30022145/second-chances
#1
Anna Dart
No abstract text is available yet for this article.
July 18, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30006588/extracellular-atp-and-p2-purinergic-signalling-in-the-tumour-microenvironment
#2
REVIEW
Francesco Di Virgilio, Alba Clara Sarti, Simonetta Falzoni, Elena De Marchi, Elena Adinolfi
Modulation of the biochemical composition of the tumour microenvironment is a new frontier of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most tumours, a condition that makes antitumour immunity ineffective. One of the most potent immunosuppressive factors is adenosine, which is generated in the tumour microenvironment owing to degradation of extracellular ATP. Accruing evidence over the past few years shows that ATP is one of the major biochemical constituents of the tumour microenvironment, where it acts at P2 purinergic receptors expressed on both tumour and host cells...
July 13, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30002479/every-step-of-the-way-integrins-in-cancer-progression-and-metastasis
#3
REVIEW
Hellyeh Hamidi, Johanna Ivaska
Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health. Integrins are the main cellular adhesion receptors that through multifaceted roles as signalling molecules, mechanotransducers and key components of the cell migration machinery are implicated in nearly every step of cancer progression from primary tumour development to metastasis. Altered integrin expression is frequently detected in tumours, where integrins have roles in supporting oncogenic growth factor receptor (GFR) signalling and GFR-dependent cancer cell migration and invasion...
July 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29988093/stat3-on-the-brain
#4
Sarah Seton-Rogers
No abstract text is available yet for this article.
July 9, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29955121/from-rock-n-roll-to-heavy-metal
#5
Ulrike Harjes
No abstract text is available yet for this article.
June 28, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29934503/success-stories
#6
Ulrike Harjes
No abstract text is available yet for this article.
June 22, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29930255/tumours-trigger-systemic-disruption
#7
Sarah Seton-Rogers
No abstract text is available yet for this article.
June 21, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29921976/falling-short-to-compete
#8
Paulina Strzyz
No abstract text is available yet for this article.
June 19, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29915184/metabolizing-microbes-in-control
#9
Anna Dart
No abstract text is available yet for this article.
June 18, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29899559/targeting-atr-in-cancer
#10
REVIEW
Emilio Lecona, Oscar Fernandez-Capetillo
The chemical treatment of cancer started with the realization that DNA damaging agents such as mustard gas present notable antitumoural properties. Consequently, early drug development focused on genotoxic chemicals, some of which are still widely used in the clinic. However, the efficacy of such therapies is often limited by the side effects of these drugs on healthy cells. A refinement to this approach is to use compounds that can exploit the presence of DNA damage in cancer cells. Given that replication stress (RS) is a major source of genomic instability in cancer, targeting the RS-response kinase ataxia telangiectasia and Rad3-related protein (ATR) has emerged as a promising alternative...
June 13, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29891962/insights-on-cancer-resistance-in-vertebrates-reptiles-as-a-parallel-system-to-mammals
#11
LETTER
Ylenia Chiari, Scott Glaberman, Vincent J Lynch
No abstract text is available yet for this article.
June 11, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29891961/eco-evolutionary-causes-and-consequences-of-temporal-changes-in-intratumoural-blood-flow
#12
REVIEW
Robert J Gillies, Joel S Brown, Alexander R A Anderson, Robert A Gatenby
Temporal changes in blood flow are commonly observed in malignant tumours, but the evolutionary causes and consequences are rarely considered. We propose that stochastic temporal variations in blood flow and microenvironmental conditions arise from the eco-evolutionary dynamics of tumour angiogenesis in which cancer cells, as individual units of selection, can influence and respond only to local environmental conditions. This leads to new vessels arising from the closest available vascular structure regardless of the size or capacity of this parental vessel...
June 11, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29875391/it-s-all-greek-to-me
#13
Anna Dart
No abstract text is available yet for this article.
June 6, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29872113/lethally-high-ros-levels-thwart-resistance
#14
Sarah Seton-Rogers
No abstract text is available yet for this article.
June 5, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29849071/author-correction-a-causal-mechanism-for-childhood-acute-lymphoblastic-leukaemia
#15
Mel Greaves
The article as originally published cited the incorrect paper as reference 123. The correct reference is Kroll, M. E., Draper, G. J., Stiller, C. A. & Murphy, M. F. G. Childhood leukemia incidence in Britain, 1974-2000: time trends and possible relation to influenza epidemics. J. Natl Cancer Inst. 98, 417-420 (2006). This has been corrected in the online and print versions of the article.
May 30, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29849070/deciphering-the-cells-of-origin-of-squamous-cell-carcinomas
#16
REVIEW
Adriana Sánchez-Danés, Cédric Blanpain
Squamous cell carcinomas (SCCs) are among the most prevalent human cancers. SCC comprises a wide range of tumours originated from diverse anatomical locations that share common genetic mutations and expression of squamous differentiation markers. SCCs arise from squamous and non-squamous epithelial tissues. Here, we discuss the different studies in which the cell of origin of SCCs has been uncovered by expressing oncogenes and/or deleting tumour suppressor genes in the different cell lineages that compose these epithelia...
May 30, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29802351/ciliary-signalling-in-cancer
#17
REVIEW
Hanqing Liu, Anna A Kiseleva, Erica A Golemis
Although tumours initiate from oncogenic changes in a cancer cell, subsequent tumour progression and therapeutic response depend on interactions between the cancer cells and the tumour microenvironment (TME). The primary monocilium, or cilium, provides a spatially localized platform for signalling by Hedgehog, Notch, WNT and some receptor tyrosine kinase pathways and mechanosensation. Changes in ciliation of cancer cells and/or cells of the TME during tumour development enforce asymmetric intercellular signalling in the TME...
May 25, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29795326/adapting-to-stress-chaperome-networks-in-cancer
#18
REVIEW
Suhasini Joshi, Tai Wang, Thaís L S Araujo, Sahil Sharma, Jeffrey L Brodsky, Gabriela Chiosis
In this Opinion article, we aim to address how cells adapt to stress and the repercussions chronic stress has on cellular function. We consider acute and chronic stress-induced changes at the cellular level, with a focus on a regulator of cellular stress, the chaperome, which is a protein assembly that encompasses molecular chaperones, co-chaperones and other co-factors. We discuss how the chaperome takes on distinct functions under conditions of stress that are executed in ways that differ from the one-on-one cyclic, dynamic functions exhibited by distinct molecular chaperones...
May 23, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29784935/a-causal-mechanism-for-childhood-acute-lymphoblastic-leukaemia
#19
REVIEW
Mel Greaves
In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation by fusion gene formation or hyperdiploidy generates a covert, pre-leukaemic clone. Second, in a small fraction of these cases, the postnatal acquisition of secondary genetic changes (primarily V(D)J recombination-activating protein (RAG) and activation-induced cytidine deaminase (AID)-driven copy number alterations in the case of ETS translocation variant 6 (ETV6)-runt-related transcription factor 1 (RUNX1)+ ALL) drives conversion to overt leukaemia...
May 21, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29777175/artificial-intelligence-in-radiology
#20
REVIEW
Ahmed Hosny, Chintan Parmar, John Quackenbush, Lawrence H Schwartz, Hugo J W L Aerts
Artificial intelligence (AI) algorithms, particularly deep learning, have demonstrated remarkable progress in image-recognition tasks. Methods ranging from convolutional neural networks to variational autoencoders have found myriad applications in the medical image analysis field, propelling it forward at a rapid pace. Historically, in radiology practice, trained physicians visually assessed medical images for the detection, characterization and monitoring of diseases. AI methods excel at automatically recognizing complex patterns in imaging data and providing quantitative, rather than qualitative, assessments of radiographic characteristics...
May 17, 2018: Nature Reviews. Cancer
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