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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/28104906/interrogating-open-issues-in-cancer-precision-medicine-with-patient-derived-xenografts
#1
Annette T Byrne, Denis G Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K Chang, Robert B Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A Jarzabek, Steven de Jong, Jos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunhild Mari Mælandsmo, Elisabetta Marangoni, Jean-Christophe Marine, Enzo Medico, Jens Henrik Norum, Héctor G Palmer, Daniel S Peeper, Pier Giuseppe Pelicci, Alejandro Piris-Gimenez, Sergio Roman-Roman, Oscar M Rueda, Joan Seoane, Violeta Serra, Laura Soucek, Dominique Vanhecke, Alberto Villanueva, Emilie Vinolo, Andrea Bertotti, Livio Trusolino
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions...
January 20, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28050011/consensus-molecular-subtypes-and-the-evolution-of-precision-medicine-in-colorectal-cancer
#2
Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar, Josep Tabernero
Critical driver genomic events in colorectal cancer have been shown to affect the response to targeted agents that were initially developed under the 'one gene, one drug' paradigm of precision medicine. Our current knowledge of the complexity of the cancer genome, clonal evolution patterns under treatment pressure and pharmacodynamic effects of target inhibition support the transition from a one gene, one drug approach to a 'multi-gene, multi-drug' model when making therapeutic decisions. Better characterization of the transcriptomic subtypes of colorectal cancer, encompassing tumour, stromal and immune components, has revealed convergent pathway dependencies that mandate a 'multi-molecular' perspective for the development of therapies to treat this disease...
January 4, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27977008/the-recurrent-architecture-of-tumour-initiation-progression-and-drug-sensitivity
#3
Andrea Califano, Mariano J Alvarez
Recent studies across multiple tumour types are starting to reveal a recurrent regulatory architecture in which genomic alterations cluster upstream of functional master regulator (MR) proteins, the aberrant activity of which is both necessary and sufficient to maintain tumour cell state. These proteins form small, hyperconnected and autoregulated modules (termed tumour checkpoints) that are increasingly emerging as optimal biomarkers and therapeutic targets. Crucially, as their activity is mostly dysregulated in a post-translational manner, rather than by mutations in their corresponding genes or by differential expression, the identification of MR proteins by conventional methods is challenging...
December 15, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27909339/cancer-cell-motility-lessons-from-migration-in-confined-spaces
#4
Colin D Paul, Panagiotis Mistriotis, Konstantinos Konstantopoulos
Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo...
December 2, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27807340/lymphoma-customized-therapeutic-delivery
#5
Sarah Seton-Rogers
No abstract text is available yet for this article.
November 3, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27982039/lymphoma-now-you-see-it
#6
Safia Danovi
No abstract text is available yet for this article.
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27932800/timps-versatile-extracellular-regulators-in-cancer
#7
Hartland W Jackson, Virginie Defamie, Paul Waterhouse, Rama Khokha
A compelling long-term goal of cancer biology is to understand the crucial players during tumorigenesis in order to develop new interventions. Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, generating simultaneous effects on tumour architecture and cell signalling. Experimental studies demonstrate the contribution of TIMPs to the majority of cancer hallmarks, and human cancers invariably show TIMP deregulation in the tumour or stroma...
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27932799/immunotherapy-switching-off-immune-suppression
#8
Sarah Seton-Rogers
No abstract text is available yet for this article.
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27909340/cell-migration-caged-for-protection
#9
Anna Dart
No abstract text is available yet for this article.
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27885265/the-disparate-origins-of-ovarian-cancers-pathogenesis-and-prevention-strategies
#10
Anthony N Karnezis, Kathleen R Cho, C Blake Gilks, Celeste Leigh Pearce, David G Huntsman
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment...
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27885264/deciphering-the-divergent-roles-of-progestogens-in-breast-cancer
#11
Jason S Carroll, Theresa E Hickey, Gerard A Tarulli, Michael Williams, Wayne D Tilley
Most breast cancers are driven by oestrogen receptor-α. Anti-oestrogenic drugs are the standard treatment for these breast cancers; however, treatment resistance is common, necessitating new therapeutic strategies. Recent preclinical and historical clinical studies support the use of progestogens to activate the progesterone receptor (PR) in breast cancers. However, widespread controversy exists regarding the role of progestogens in this disease, hindering the clinical implementation of PR-targeted therapies...
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834398/cancer-nanomedicine-progress-challenges-and-opportunities
#12
Jinjun Shi, Philip W Kantoff, Richard Wooster, Omid C Farokhzad
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a new paradigm in cancer therapy stem from the complexities and heterogeneity of tumour biology, an incomplete understanding of nano-bio interactions and the challenges regarding chemistry, manufacturing and controls required for clinical translation and commercialization...
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834397/the-genetics-of-myelodysplastic-syndrome-from-clonal-haematopoiesis-to-secondary-leukaemia
#13
Adam S Sperling, Christopher J Gibson, Benjamin L Ebert
Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of mutated haematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal haematopoiesis of indeterminate potential (CHIP) to secondary acute myeloid leukaemia (sAML), MDS is distinguished by the presence of peripheral blood cytopenias, dysplastic haematopoietic differentiation and the absence of features that define acute leukaemia. More than 50 recurrently mutated genes are involved in the pathogenesis of MDS, including genes that encode proteins involved in pre-mRNA splicing, epigenetic regulation and transcription...
January 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27999430/leukaemia-don-t-let-sleeping-cells-lie
#14
M Teresa Villanueva
No abstract text is available yet for this article.
December 21, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27999429/chemotherapy-less-is-more
#15
Anna Dart
No abstract text is available yet for this article.
December 21, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27999428/tumour-initiating-cells-the-cell-that-rocks-the-tumour
#16
M Teresa Villanueva
No abstract text is available yet for this article.
December 21, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27999427/cancer-genetics-x-inactivation-and-cancer-incidence
#17
Sarah Seton-Rogers
No abstract text is available yet for this article.
December 21, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834399/pancreatic-cancer-fast-or-slow
#18
Sarah Seton-Rogers
No abstract text is available yet for this article.
December 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834396/tumorigenesis-networking-a-survival-guide
#19
Anna Dart
No abstract text is available yet for this article.
December 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27811947/tumour-microenvironment-that-gut-feeling
#20
Anna Dart
No abstract text is available yet for this article.
December 2016: Nature Reviews. Cancer
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