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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/28643779/drugging-the-undruggable-cancer-targets
#1
REVIEW
Chi V Dang, E Premkumar Reddy, Kevan M Shokat, Laura Soucek
The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these targets, and therefore more appropriate terms might be 'difficult to drug' or 'yet to be drugged'. Many desirable targets in cancer fall into this category, including the RAS and MYC oncogenes, and pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new technologies...
June 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642602/tumour-immunology-lap-targeting-reduces-tolerogenic-cells-in-cancer
#2
Alexandra Flemming
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642605/immunotherapy-macrophages-steal-the-show
#3
M Teresa Villanueva
No abstract text is available yet for this article.
July 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642606/transposable-elements-in-cancer
#4
REVIEW
Kathleen H Burns
Transposable elements give rise to interspersed repeats, sequences that comprise most of our genomes. These mobile DNAs have been historically underappreciated - both because they have been presumed to be unimportant, and because their high copy number and variability pose unique technical challenges. Neither impediment now seems steadfast. Interest in the human mobilome has never been greater, and methods enabling its study are maturing at a fast pace. This Review describes the activity of transposable elements in human cancers, particularly long interspersed element-1 (LINE-1)...
July 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642600/cancer-models-tailored-mouse-models
#5
Anna Dart
No abstract text is available yet for this article.
July 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642598/leukaemia-unravelling-the-heterogeneity-of-cancer-stem-cells
#6
Sarah Seton-Rogers
No abstract text is available yet for this article.
July 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28524181/common-pitfalls-in-preclinical-cancer-target-validation
#7
REVIEW
William G Kaelin
An alarming number of papers from laboratories nominating new cancer drug targets contain findings that cannot be reproduced by others or are simply not robust enough to justify drug discovery efforts. This problem probably has many causes, including an underappreciation of the danger of being misled by off-target effects when using pharmacological or genetic perturbants in complex biological assays. This danger is particularly acute when, as is often the case in cancer pharmacology, the biological phenotype being measured is a 'down' readout (such as decreased proliferation, decreased viability or decreased tumour growth) that could simply reflect a nonspecific loss of cellular fitness...
July 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28450704/melanoma-a-global-perspective
#8
Raul Ossio, Rodrigo Roldán-Marín, Héctor Martínez-Said, David J Adams, Carla Daniela Robles-Espinoza
Most of our current knowledge of melanoma is derived from the study of patients from populations of European descent, for whom public health, sun protection initiatives and screening measures have appreciably decreased disease mortality. Notably, some melanoma subtypes that most commonly develop in other populations are not associated with exposure to ultraviolet (UV) light, suggesting a different disease aetiology. Further study of these subtypes is necessary to understand their risk factors and genomic architecture, and to tailor therapies and public health campaigns to benefit patients of all ethnic groups...
July 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642607/tumour-metabolism-losing-that-remaining-fat
#9
Anna Dart
No abstract text is available yet for this article.
June 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642604/turning-the-tide-in-myelodysplastic-myeloproliferative-neoplasms
#10
REVIEW
Michael W N Deininger, Jeffrey W Tyner, Eric Solary
Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive myeloid malignancies recognized as a distinct category owing to their unique combination of dysplastic and proliferative features. Although current classification schemes still emphasize morphology and exclusionary criteria, disease-defining somatic mutations and/or germline predisposition alleles are increasingly incorporated into diagnostic algorithms. The developing picture suggests that phenotypes are driven mostly by epigenetic mechanisms that reflect a complex interplay between genotype, physiological processes such as ageing and interactions between malignant haematopoietic cells and the stromal microenvironment of the bone marrow...
June 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642603/imaging-of-anticancer-drug-action-in-single-cells
#11
REVIEW
Miles A Miller, Ralph Weissleder
Imaging is widely used in anticancer drug development, typically for whole-body tracking of labelled drugs to different organs or to assess drug efficacy through volumetric measurements. However, increasing attention has been drawn to pharmacology at the single-cell level. Diverse cell types, including cancer-associated immune cells, physicochemical features of the tumour microenvironment and heterogeneous cell behaviour all affect drug delivery, response and resistance. This Review summarizes developments in the imaging of in vivo anticancer drug action, with a focus on microscopy approaches at the single-cell level and translational lessons for the clinic...
June 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642601/cancer-models-modeling-clear-cell-renal-cell-carcinoma
#12
Anna Dart
No abstract text is available yet for this article.
June 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642599/targeted-therapies-expanding-the-use-of-parp-inhibitors
#13
Sarah Seton-Rogers
No abstract text is available yet for this article.
June 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28497812/metastasis-the-plastic-state
#14
Anna Dart
No abstract text is available yet for this article.
June 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28474690/tumorigenesis-cancer-as-a-symptom-of-evolution
#15
Gemma K Alderton
No abstract text is available yet for this article.
June 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28450705/the-ets-family-of-oncogenic-transcription-factors-in-solid-tumours
#16
REVIEW
Gina M Sizemore, Jason R Pitarresi, Subhasree Balakrishnan, Michael C Ostrowski
Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth factor signalling loops, formation of gain-of-function co-regulatory complexes and novel cis-acting mutations in ETS target gene promoters can result in increased ETS activity. In turn, pro-oncogenic ETS signalling enhances tumorigenesis through a broad mechanistic toolbox that includes lineage specification and self-renewal, DNA damage and genome instability, epigenetics and metabolism...
June 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28416802/rna-editing-dependent-epitranscriptome-diversity-in-cancer-stem-cells
#17
REVIEW
Qingfei Jiang, Leslie A Crews, Frida Holm, Catriona H M Jamieson
Cancer stem cells (CSCs) can regenerate all facets of a tumour as a result of their stem cell-like capacity to self-renew, survive and become dormant in protective microenvironments. CSCs evolve during tumour progression in a manner that conforms to Charles Darwin's principle of natural selection. Although somatic DNA mutations and epigenetic alterations promote evolution, post-transcriptional RNA modifications together with RNA binding protein activity (the 'epitranscriptome') might also contribute to clonal evolution through dynamic determination of RNA function and gene expression diversity in response to environmental stimuli...
June 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28386091/the-calcium-cancer-signalling-nexus
#18
REVIEW
Gregory R Monteith, Natalia Prevarskaya, Sarah J Roberts-Thomson
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past decade there has been a deeper understanding of how calcium signalling is remodelled in some cancers and the consequences of calcium signalling on key events such as proliferation, invasion and sensitivity to cell death...
June 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28536455/immunotherapy-programming-t-cells-in-situ
#19
Sarah Seton-Rogers
No abstract text is available yet for this article.
May 24, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28536454/immunotherapy-t-cells-get-a-ride
#20
M Teresa Villanueva
No abstract text is available yet for this article.
May 24, 2017: Nature Reviews. Cancer
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