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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/30420767/cell-in-cell-phenomena-in-cancer
#1
REVIEW
Stefano Fais, Michael Overholtzer
Cell-in-cell structures are reported in numerous cancers, and their presence is an indicator for poor prognosis. Mechanistic studies have identified how cancer cells manage to ingest whole neighbouring cells to form such structures, and the consequences of cell-in-cell formation on cancer progression have been elucidated. In this Opinion article, we discuss how two related cell-in-cell processes, cell cannibalism and entosis, are regulated and how these mechanisms promote cancer progression. We propose that cannibalistic activity is a hallmark of cancer that results in part from selection by metabolic stress and serves to feed aggressive cancer cells...
November 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30420766/colony-takeover
#2
Anna Dart
No abstract text is available yet for this article.
November 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30420765/a-model-for-ras-mutation-patterns-in-cancers-finding-the-sweet-spot
#3
REVIEW
Siqi Li, Allan Balmain, Christopher M Counter
The three RAS genes - HRAS, NRAS and KRAS - are collectively mutated in one-third of human cancers, where they act as prototypic oncogenes. Interestingly, there are rather distinct patterns to RAS mutations; the isoform mutated as well as the position and type of substitution vary between different cancers. As RAS genes are among the earliest, if not the first, genes mutated in a variety of cancers, understanding how these mutation patterns arise could inform on not only how cancer begins but also the factors influencing this event, which has implications for cancer prevention...
November 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30405213/tumour-targeting-bacteria-engineered-to-fight-cancer
#4
REVIEW
Shibin Zhou, Claudia Gravekamp, David Bermudes, Ke Liu
Recent advances in targeted therapy and immunotherapy have once again raised the hope that a cure might be within reach for many cancer types. Yet, most late-stage cancers are either insensitive to the therapies to begin with or develop resistance later. Therapy with live tumour-targeting bacteria provides a unique option to meet these challenges. Compared with most other therapeutics, the effectiveness of tumour-targeting bacteria is not directly affected by the 'genetic makeup' of a tumour. Bacteria initiate their direct antitumour effects from deep within the tumour, followed by innate and adaptive antitumour immune responses...
November 7, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30390019/ageing-matrix-promotes-metastasis
#5
Sarah Seton-Rogers
No abstract text is available yet for this article.
November 2, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30385874/sabotaging-the-host
#6
Maria Giuseppina Baratta
No abstract text is available yet for this article.
November 1, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30382160/myc-in-elongation-and-repression
#7
Eytan Zlotorynski
No abstract text is available yet for this article.
October 31, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30361637/waking-up-in-a-trap
#8
Anna Dart
No abstract text is available yet for this article.
October 25, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30361636/car-antigens-beyond-recognition
#9
Ulrike Harjes
No abstract text is available yet for this article.
October 25, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30209308/changing-mutational-patterns
#10
Sarah Seton-Rogers
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30209307/publisher-correction-the-molecular-landscape-of-head-and-neck-cancer
#11
C René Leemans, Peter J F Snijders, Ruud H Brakenhoff
The article as originally published contained errors in Figure 3. The direction of the arrows associated with the labels for p53 and RB were incorrect. This has now been corrected in all versions of the article.
September 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30337715/publisher-correction-engineering-and-physical-sciences-in-oncology-challenges-and-opportunities
#12
Michael J Mitchell, Rakesh K Jain, Robert Langer
The article as originally published incorrectly cited reference 31 in the legend for figure 7. The correct reference should have been reference 132 (Angelo, M. et al. Multiplexed ion beam imaging of human breast tumors. Nat. Med. 20, 436-442 (2014)).
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30327499/fasting-and-cancer-molecular-mechanisms-and-clinical-application
#13
REVIEW
Alessio Nencioni, Irene Caffa, Salvatore Cortellino, Valter D Longo
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) lead to wide alterations in growth factors and in metabolite levels, generating environments that can reduce the capability of cancer cells to adapt and survive and thus improving the effects of cancer therapies. In addition, fasting or FMDs increase resistance to chemotherapy in normal but not cancer cells and promote regeneration in normal tissues, which could help prevent detrimental and potentially life-threatening side effects of treatments...
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30323316/back-to-the-beginning-to-understand-metastasis
#14
Sarah Seton-Rogers
No abstract text is available yet for this article.
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30310146/oncogenic-mrna-modification-explained
#15
Ulrike Harjes
No abstract text is available yet for this article.
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30310145/new-targets-for-cancer-immunotherapy
#16
Anna Dart
No abstract text is available yet for this article.
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30310144/spop-mutations-disrupt-phase-separation
#17
Sarah Seton-Rogers
No abstract text is available yet for this article.
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30301932/neighbourly-deaths-dictate-fate
#18
Anna Dart
No abstract text is available yet for this article.
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30301931/betting-on-yap-taz
#19
Ulrike Harjes
No abstract text is available yet for this article.
November 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30293088/the-cosmic-cancer-gene-census-describing-genetic-dysfunction-across-all-human-cancers
#20
REVIEW
Zbyslaw Sondka, Sally Bamford, Charlotte G Cole, Sari A Ward, Ian Dunham, Simon A Forbes
The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC) is an expert-curated description of the genes driving human cancer that is used as a standard in cancer genetics across basic research, medical reporting and pharmaceutical development. After a major expansion and complete re-evaluation, the 2018 CGC describes in detail the effect of 719 cancer-driving genes. The recent expansion includes functional and mechanistic descriptions of how each gene contributes to disease generation in terms of the key cancer hallmarks and the impact of mutations on gene and protein function...
November 2018: Nature Reviews. Cancer
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