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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/30242216/mrna-alterations-mimic-genetic-mutations
#1
Sarah Seton-Rogers
No abstract text is available yet for this article.
September 21, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30228301/stem-cell-fate-in-cancer-growth-progression-and-therapy-resistance
#2
REVIEW
Nikki K Lytle, Alison G Barber, Tannishtha Reya
Although we have come a long way in our understanding of the signals that drive cancer growth, and how these signals can be targeted, effective control of this disease remains a key scientific and medical challenge. The therapy resistance and relapse that are commonly seen are driven in large part by the inherent heterogeneity within cancers that allows drugs to effectively eliminate some, but not all, malignant cells. Here, we focus on the fundamental drivers of this heterogeneity by examining emerging evidence that shows that these traits are often controlled by the disruption of normal cell fate and aberrant adoption of stem cell signals...
September 18, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30209308/changing-mutational-patterns
#3
Sarah Seton-Rogers
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30209307/publisher-correction-the-molecular-landscape-of-head-and-neck-cancer
#4
C René Leemans, Peter J F Snijders, Ruud H Brakenhoff
The article as originally published contained errors in Figure 3. The direction of the arrows associated with the labels for p53 and RB were incorrect. This has now been corrected in all versions of the article.
September 12, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30194362/rewiring-urea-cycle-metabolism-in-cancer-to-support-anabolism
#5
REVIEW
Rom Keshet, Peter Szlosarek, Arkaitz Carracedo, Ayelet Erez
Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the anabolic synthesis of macromolecules that are required during tumour proliferation and growth. To achieve this aim, one strategy is to reduce catabolism and nitrogen disposal. The urea cycle (UC) in the liver is the main metabolic pathway to convert excess nitrogen into disposable urea. Outside the liver, UC enzymes are differentially expressed, enabling the use of nitrogen for the synthesis of UC intermediates that are required to accommodate cellular needs...
September 7, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30185950/publisher-correction-structural-underpinnings-of-oestrogen-receptor-mutations-in-endocrine-therapy-resistance
#6
John A Katzenellenbogen, Christopher G Mayne, Benita S Katzenellenbogen, Geoffrey L Greene, Sarat Chandarlapaty
The originally published article contained an error in the legend of supplementary figure 1. A figure permission line was left off. The correct figure permission line has now been added to the HTML and PDF versions of the article, stating that "Data shown in (B) and (C) of this figure were originally published in Jeyakumar, M., Carlson, K. E., Gunther, J. R. & Katzenellenbogen, J. A. Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities. J. Biol. Chem...
September 5, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30181570/polyamine-metabolism-and-cancer-treatments-challenges-and-opportunities
#7
REVIEW
Robert A Casero, Tracy Murray Stewart, Anthony E Pegg
Advances in our understanding of the metabolism and molecular functions of polyamines and their alterations in cancer have led to resurgence in the interest of targeting polyamine metabolism as an anticancer strategy. Increasing knowledge of the interplay between polyamine metabolism and other cancer-driving pathways, including the PTEN-PI3K-mTOR complex 1 (mTORC1), WNT signalling and RAS pathways, suggests potential combination therapies that will have considerable clinical promise. Additionally, an expanding number of promising clinical trials with agents targeting polyamines for both therapy and prevention are ongoing...
September 4, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30171199/in-search-of-missing-t-cells
#8
Isobel Leake
No abstract text is available yet for this article.
August 31, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30158651/epigenetic-control-by-sugar
#9
Ulrike Harjes
No abstract text is available yet for this article.
August 29, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30158650/leukaemic-escape-routes
#10
Anna Dart
No abstract text is available yet for this article.
August 29, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30116020/cancer-in-wildlife-patterns-of-emergence
#11
REVIEW
Patricia A Pesavento, Dalen Agnew, Michael K Keel, Kevin D Woolard
Cancer is ubiquitous in wildlife, affecting animals from bivalves to pachyderms and cetaceans. Reports of increasing frequency demonstrate that neoplasia is associated with substantial mortality in wildlife species. Anthropogenic activities and global weather changes are shaping new geographical limitations for many species, and alterations in living niches are associated with visible examples of genetic bottlenecks, toxin exposures, oncogenic pathogens, stress and immunosuppression, which can all contribute to cancers in wild species...
August 16, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30097614/nutrient-scavenging-in-cancer
#12
REVIEW
Brendan T Finicle, Vaishali Jayashankar, Aimee L Edinger
While cancer cell proliferation depends on access to extracellular nutrients, inadequate tumour perfusion means that glucose, amino acids and lipids are often in short supply. To overcome this obstacle to growth, cancer cells utilize multiple scavenging strategies, obtaining macromolecules from the microenvironment and breaking them down in the lysosome to produce substrates for ATP generation and anabolism. Recent studies have revealed four scavenging pathways that support cancer cell proliferation in low-nutrient environments: scavenging of extracellular matrix proteins via integrins, receptor-mediated albumin uptake and catabolism, macropinocytic consumption of multiple components of the tumour microenvironment and the engulfment and degradation of entire live cells via entosis...
August 10, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30006588/extracellular-atp-and-p2-purinergic-signalling-in-the-tumour-microenvironment
#13
REVIEW
Francesco Di Virgilio, Alba Clara Sarti, Simonetta Falzoni, Elena De Marchi, Elena Adinolfi
Modulation of the biochemical composition of the tumour microenvironment is a new frontier of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most tumours, a condition that makes antitumour immunity ineffective. One of the most potent immunosuppressive factors is adenosine, which is generated in the tumour microenvironment owing to degradation of extracellular ATP. Accruing evidence over the past few years shows that ATP is one of the major biochemical constituents of the tumour microenvironment, where it acts at P2 purinergic receptors expressed on both tumour and host cells...
July 13, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29988093/stat3-on-the-brain
#14
Sarah Seton-Rogers
No abstract text is available yet for this article.
July 9, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30072780/the-sugar-loop
#15
Ulrike Harjes
No abstract text is available yet for this article.
September 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30061713/subclones-work-together
#16
Sarah Seton-Rogers
No abstract text is available yet for this article.
September 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30050149/how-to-predict-the-future
#17
Anna Dart
No abstract text is available yet for this article.
September 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30030494/clinical-tumour-sequencing-for-precision-oncology-time-for-a-universal-strategy
#18
Michael L Cheng, Michael F Berger, David M Hyman, David B Solit
No abstract text is available yet for this article.
September 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30022145/second-chances
#19
Anna Dart
No abstract text is available yet for this article.
September 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/30002479/every-step-of-the-way-integrins-in-cancer-progression-and-metastasis
#20
REVIEW
Hellyeh Hamidi, Johanna Ivaska
Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health. Integrins are the main cellular adhesion receptors that through multifaceted roles as signalling molecules, mechanotransducers and key components of the cell migration machinery are implicated in nearly every step of cancer progression from primary tumour development to metastasis. Altered integrin expression is frequently detected in tumours, where integrins have roles in supporting oncogenic growth factor receptor (GFR) signalling and GFR-dependent cancer cell migration and invasion...
September 2018: Nature Reviews. Cancer
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