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Nature Reviews. Cancer

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https://www.readbyqxmd.com/read/27932800/timps-versatile-extracellular-regulators-in-cancer
#1
Hartland W Jackson, Virginie Defamie, Paul Waterhouse, Rama Khokha
A compelling long-term goal of cancer biology is to understand the crucial players during tumorigenesis in order to develop new interventions. Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, generating simultaneous effects on tumour architecture and cell signalling. Experimental studies demonstrate the contribution of TIMPs to the majority of cancer hallmarks, and human cancers invariably show TIMP deregulation in the tumour or stroma...
December 9, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27932799/immunotherapy-switching-off-immune-suppression
#2
Sarah Seton-Rogers
No abstract text is available yet for this article.
December 9, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27909340/cell-migration-caged-for-protection
#3
Anna Dart
No abstract text is available yet for this article.
December 2, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27909339/cancer-cell-motility-lessons-from-migration-in-confined-spaces
#4
Colin D Paul, Panagiotis Mistriotis, Konstantinos Konstantopoulos
Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo...
December 2, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27885265/the-disparate-origins-of-ovarian-cancers-pathogenesis-and-prevention-strategies
#5
Anthony N Karnezis, Kathleen R Cho, C Blake Gilks, Celeste Leigh Pearce, David G Huntsman
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment...
November 25, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27885264/deciphering-the-divergent-roles-of-progestogens-in-breast-cancer
#6
Jason S Carroll, Theresa E Hickey, Gerard A Tarulli, Michael Williams, Wayne D Tilley
Most breast cancers are driven by oestrogen receptor-α. Anti-oestrogenic drugs are the standard treatment for these breast cancers; however, treatment resistance is common, necessitating new therapeutic strategies. Recent preclinical and historical clinical studies support the use of progestogens to activate the progesterone receptor (PR) in breast cancers. However, widespread controversy exists regarding the role of progestogens in this disease, hindering the clinical implementation of PR-targeted therapies...
November 25, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834398/cancer-nanomedicine-progress-challenges-and-opportunities
#7
Jinjun Shi, Philip W Kantoff, Richard Wooster, Omid C Farokhzad
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a new paradigm in cancer therapy stem from the complexities and heterogeneity of tumour biology, an incomplete understanding of nano-bio interactions and the challenges regarding chemistry, manufacturing and controls required for clinical translation and commercialization...
November 11, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834397/the-genetics-of-myelodysplastic-syndrome-from-clonal-haematopoiesis-to-secondary-leukaemia
#8
Adam S Sperling, Christopher J Gibson, Benjamin L Ebert
Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of mutated haematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal haematopoiesis of indeterminate potential (CHIP) to secondary acute myeloid leukaemia (sAML), MDS is distinguished by the presence of peripheral blood cytopenias, dysplastic haematopoietic differentiation and the absence of features that define acute leukaemia. More than 50 recurrently mutated genes are involved in the pathogenesis of MDS, including genes that encode proteins involved in pre-mRNA splicing, epigenetic regulation and transcription...
November 11, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27811947/tumour-microenvironment-that-gut-feeling
#9
Anna Dart
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27807340/lymphoma-customized-therapeutic-delivery
#10
Sarah Seton-Rogers
No abstract text is available yet for this article.
November 3, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27739506/tumour-metabolism-building-up-and-breaking-down-fatty-acids
#11
Sarah Seton-Rogers
No abstract text is available yet for this article.
October 14, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27739505/cell-differentiation-pushing-differentiation
#12
M Teresa Villanueva
No abstract text is available yet for this article.
October 14, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27713543/tumour-metabolism-lactic-acid-not-just-a-waste-product
#13
Anna Dart
No abstract text is available yet for this article.
October 7, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27687982/epstein-barr-virus-more-than-50-years-old-and-still-providing-surprises
#14
Lawrence S Young, Lee Fah Yap, Paul G Murray
It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer...
September 30, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27687981/tumour-metabolism-translating-the-undruggable-target
#15
Anna Dart
No abstract text is available yet for this article.
September 30, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27687979/mouse-models-in-oncoimmunology
#16
Laurence Zitvogel, Jonathan M Pitt, Romain Daillère, Mark J Smyth, Guido Kroemer
Fundamental cancer research and the development of efficacious antineoplastic treatments both rely on experimental systems in which the relationship between malignant cells and immune cells can be studied. Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies - each with their specific advantages and difficulties - have laid the foundations of oncoimmunology. These models have guided the immunosurveillance theory that postulates that evasion from immune control is an essential feature of cancer, the concept that the long-term effects of conventional cancer treatments mostly rely on the reinstatement of anticancer immune responses and the preclinical development of immunotherapies, including currently approved immune checkpoint blockers...
September 30, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834399/pancreatic-cancer-fast-or-slow
#17
Sarah Seton-Rogers
No abstract text is available yet for this article.
December 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27834396/tumorigenesis-networking-a-survival-guide
#18
Anna Dart
No abstract text is available yet for this article.
December 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27782134/gap-junctions-and-cancer-communicating-for-50-years
#19
Trond Aasen, Marc Mesnil, Christian C Naus, Paul D Lampe, Dale W Laird
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support the notion that connexins are tumour suppressors, recent evidence suggests that, in some tumour types, they may facilitate specific stages of tumour progression through both junctional and non-junctional signalling pathways...
December 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27658528/maintaining-cell-identity-prc2-mediated-regulation-of-transcription-and-cancer
#20
Itys Comet, Eva M Riising, Benjamin Leblanc, Kristian Helin
Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive complex 2 (PRC2), has attracted broad research attention in the past few years because of its involvement in the development and maintenance of many types of cancer and the use of specific EZH2 inhibitors in clinical trials. Several observations show that PRC2 can have both oncogenic and tumour-suppressive functions. We propose that these apparently opposing roles of PRC2 in cancer are a consequence of the molecular function of the complex in maintaining, rather than specifying, the transcriptional repression state of its several thousand target genes...
December 2016: Nature Reviews. Cancer
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