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Expert Review of Anticancer Therapy

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https://www.readbyqxmd.com/read/29125367/recent-advances-in-the-management-of-pancreatic-adenocarcinoma
#1
Yusuf Karakas, Sahin Lacin, Suayib Yalcin
Pancreatic cancer (PC) demonstrates very poor prognosis and its incidence continues to increase, despite developments in chemotherapy, radiotherapy, and targeted therapies. Surgical resection is currently the only curative approach for PC. The role of radiotherapy in adjuvant and locally advanced PC continues to be increasingly controversial. This review article aims to explore the current knowledge of pancreatic adenocarcinoma, focusing on diagnosis, treatment strategies, and the best supportive care. Areas covered: The current literature on pancreatic adenocarcinoma treatment modalities has been summarized, with a focus on clinical trials and reviews...
November 13, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29125369/pregnancy-and-live-birth-after-successful-cancer-treatment-in-young-women-the-need-to-improve-fertility-preservation-and-advice-for-female-cancer-patients
#2
Richard A Anderson, W Hamish B Wallace
No abstract text is available yet for this article.
November 10, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29115166/incorporating-age-into-international-germ-cell-consensus-classification-igccc-a-time-to-move-forward
#3
Omar Abdel-Rahman
No abstract text is available yet for this article.
November 8, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29110548/new-targets-and-therapies-for-gastrointestinal-stromal-tumors
#4
Agnieszka Wozniak, Yemarshet K Gebreyohannes, Maria Debiec-Rychter, Patrick Schöffski
The majority of gastrointestinal stromal tumors (GIST) are driven by an abnormal receptor tyrosine kinase (RTK) signaling, occurring mainly due to somatic mutations in KIT or platelet derived growth factor receptor alpha (PDGFRA). Although the introduction of tyrosine kinase inhibitors (TKIs) has revolutionized therapy for GIST patients, with time the vast majority of them develop TKI resistance. Advances in understanding the molecular background of GIST resistance allows for the identification of new targets and the development of novel strategies to overcome or delay its occurrence...
November 7, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29086618/optimizing-treatment-in-recurrent-epithelial-ovarian-cancer
#5
Giacomo Corrado, Vanda Salutari, Eleonora Palluzzi, Maria Grazia Distefano, Giovanni Scambia, Gabriella Ferrandina
Optimal management of recurrent ovarian cancer (ROC) remains an area of uncertainty. An estimated 85% of patients with epithelial ovarian cancer who achieve a full remission following first-line therapy will develop recurrent disease and median survival for these patients' ranges from 12 months to 24 months. Many patients receive several lines of treatment following recurrence and, although each subsequent line of therapy is characterized by shorter disease-free intervals, decisions about the most appropriate treatment is complex...
November 6, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29069959/the-liquid-biopsy-a-tool-for-a-combined-diagnostic-and-theranostic-approach-for-care-of-a-patient-with-late-stage-lung-carcinoma-presenting-with-bilateral-ocular-metastases
#6
Linda Bouhlel, Véronique Hofman, Célia Maschi, Marius Ilié, Maryline Allégra, Charles-Hugo Marquette, Clarisse Audigier-Valette, Juliette Thariat, Paul Hofman
Liquid biopsies (LB) are used routinely in clinical practice in two situations for late stage non-small-cell lung cancer (NSCLC) patients, (i) at the initial diagnosis when looking for activating mutations in EGFR in the absence of analyzable tissue DNA and, (ii) during tumor progression on a tyrosine kinase inhibitor treatment to look for the resistance mutation T790M in EGFR. LB is not presently recommended in daily practice for the diagnosis of NSCLC. Areas covered: We report the diagnosis of a NSCLC in a patient with bilateral ocular metastases after detection of a deletion in exon 19 of EGFR when using plasma DNA...
November 2, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29048935/chimeric-antigen-receptor-t-cell-therapy-for-solid-tumors-require-new-clinical-regimens
#7
Jinjing Xu, Kang Tian, Haixu Zhang, Liantao Li, Hongyan Liu, Jingjie Liu, Qing Zhang, Junnian Zheng
Chimeric antigen receptor modified T cell (CAR-T) therapy has achieved encouraging breakthroughs in the treatment of hematological malignancies. Nevertheless, this success has not yet been extrapolated to solid tumors. This review focuses on new clinical regimens that could improve the therapeutic efficacy of CAR-T in solid tumors. Areas covered: Herein, the authors reviewed recent clinical trials using CAR-T therapies for the treatment of solid tumors. Specifically, this review covered the following areas: (1) the current status of CAR-T cells in the treatment of solid tumors; (2) the major factors constraining the efficacy of CAR-T cells in solid tumors; and (3) opinions regarding the future of CAR-T as a treatment for solid tumors...
October 26, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29048943/prognostic-value-of-the-combination-of-serum-levels-of-vascular-endothelial-growth-factor-c-reactive-protein-and-contrast-enhanced-ultrasound-in-patients-with-primary-liver-cancer-who-underwent-transcatheter-arterial-chemoembolization
#8
Zhi-Dong Xuan, Li Zhou, Yu Wang, Xue Zheng
BACKGROUND: This study aimed to evaluate the prognostic value of the combination of serum levels of vascular endothelial growth factor (VEGF), C-reactive protein (CRP), and contrast-enhanced ultrasound (CEUS) in patients with primary liver cancer (PLC) after transcatheter arterial chemoembolization (TACE). RESEARCH DESIGN AND METHODS: Overall, 287 PLC patients who had undergone TACE were allocated into recurrence and non-recurrence groups. One day before and seven days after TACE, CEUS was performed, and serum VEGF and CRP levels were determined...
October 19, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29022408/screening-of-colorectal-cancer-present-and-future
#9
Marcello Maida, Fabio Salvatore Macaluso, Gianluca Ianiro, Francesca Mangiola, Emanuele Sinagra, Georgina Hold, Carlo Maida, Giovanni Cammarota, Antonio Gasbarrini, Giuseppe Scarpulla
Colorectal cancer (CRC) is the third most common cancer in males and second in females, and the fourth most common cause of cancer death worldwide. Currently, about 60-70% of diagnosed cases in symptomatic patients are detected at an advanced stage of disease. Earlier stage detection through the use of screening strategies would allow for better outcomes in terms of reducing the disease burden. Areas covered: The aim of this paper is to review the current published evidence from literature which assesses the performance and effectiveness of different screening tests for the early detection of CRC...
October 12, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28988510/tyrosine-kinase-inhibitors-rechallenge-in-solid-tumors-a-review-of-literature-and-a-case-description-with-lenvatinib-in-thyroid-cancer
#10
Francesco Felicetti, Alice Nervo, Alessandro Piovesan, Rita Berardelli, Filippo Marchisio, Marco Gallo, Emanuela Arvat
In the last decade tyrosine kinase inhibitors (TKIs) have been employed for a wide range of hematological and solid tumors and today they represent a valid therapeutic option for different neoplasms. Among them, both sorafenib and lenvatinib were approved for the treatment of radioactive iodine (RAI) refractory differentiated thyroid carcinoma (DTC). Unfortunately, in some cases the efficacy of TKIs is limited by the onset of drug resistance after the initial response. Areas Covered: We report the case of a patient with a RAI refractory advanced DTC, treated with lenvatinib after surgery, multiple RAI administrations, traditional chemotherapy, and sorafenib...
October 9, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28988501/dermatofibrosarcoma-protuberans-and-gastrointestinal-stromal-tumor-as-models-for-targeted-therapy-in-soft-tissue-sarcomas
#11
Hanna Koseła-Paterczyk, Piotr Rutkowski
The development of novel targeted treatment in soft tissue sarcomas (STS) is important since many sarcoma subtypes are resistant to conventional chemotherapy and effective therapeutic options are limited. Areas covered: This review discusses the molecular background and treatment in two STS types which became a model for targeted therapy - gastrointestinal stromal tumor (GIST) and dermatofibrosarcoma protuberans (DFSP). DFSP is characterized, in the majority of cases, by chromosomal translocation which results in the formation of COL1A1-PDGFB fusion gene causing platelet-derived growth factor receptor beta(PDGFRB) signaling activation in tumor cells...
October 9, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28933973/magnetic-resonance-imaging-in-the-early-detection-of-prostate-cancer-and-review-of-the-literature-on-magnetic-resonance-imaging-stratified-clinical-pathways
#12
Taimur Tariq Shah, Wilson King Lim To, Hashim Uddin Ahmed
With level 1 evidence now available on the diagnostic accuracy of multiparametric magnetic resonance imaging (MRI) we must now utilise this data in developing an MRI-stratified diagnostic pathway for the early detection of prostate cancer. Areas covered: A literature review was conducted and identified seven randomised control trials (RCT's) assessing the diagnostic accuracy of such a pathway against the previously accepted systematic/random trans-rectal ultrasound guided (TRUS) biopsy pathway. The studies were heterogeneous in their design...
September 28, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28929817/minimum-unit-pricing-for-alcohol-the-most-cost-effective-of-cancer-prevention-strategies
#13
Timothy Stockwell
No abstract text is available yet for this article.
September 25, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28854837/castration-naive-metastatic-prostate-cancer-reshaping-old-paradigms
#14
Raffaele Ratta, Paolo Grassi, Giovanni Fucà, Elena Verzoni, Giuseppe Procopio
No abstract text is available yet for this article.
September 11, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28922958/post-prostatectomy-radiation-therapy-for-locally-recurrent-prostate-cancer
#15
REVIEW
Sudhir Isharwal, Andrew J Stephenson
Approximately 15-30% of men with localized prostate cancer will experience biochemical recurrence (BCR) after radical prostatectomy. Postoperative radiation therapy is used in men with adverse pathological features to reduce the risk of BCR or with curative intent in men with known BCR. In this study, we review the evidence for the adjuvant and salvage radiation therapy after radical prostatectomy. Areas covered: A literature review of the Medline and Embase databases was performed. The search strategy included the following terms: prostate cancer, adjuvant radiotherapy, salvage radiotherapy, radical prostatectomy, biochemical recurrence, and prostate cancer recurrence...
November 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28910204/chemotherapy-induced-neutropenia-and-the-prognosis-of-colorectal-cancer-a-meta-analysis-of-cohort-studies
#16
REVIEW
XiangZhou Tan, QiaoCheng Wen, Ran Wang, ZhiKang Chen
INTRODUCTION: Recently, there has been a controversial discussion about the prognostic value of chemotherapy-induced neutropenia (CIN) in colorectal cancer patients. Thus, a meta-analysis was conducted to determine the relationship between CIN and the prognosis of colorectal cancer patients. METHODS: We searched the PubMed, EMBASE, and Cochrane library databases to identify studies evaluating the association between CIN and colorectal cancer prognosis. Pooled random/fixed effect models were used to calculate pooled hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the association...
November 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28889760/an-analysis-of-clinical-characteristics-and-patient-outcomes-in-primary-mediastinal-sarcomas
#17
Omar Abdel-Rahman
BACKGROUND: Published data concerning primary mediastinal sarcomas are limited to small-sized retrospective series.  This study reviewed the clinical outcomes of these cases from the SEER (surveillance, epidemiology and end results) database. METHODS: Primary mediastinal sarcomas (1988 - 2013) were assembled from the SEER database. The incidence and 10-year cancer-specific survival rates were compared to other primary mediastinal malignancies (thymic carcinoma, germ cell tumors, neurogenic tumors, Hodgkin / non Hodgkin lymphomas) as well as to non mediastinal sarcomas...
November 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28868935/risk-reduction-and-treatment-of-chemotherapy-induced-peripheral-neuropathy
#18
REVIEW
Marios Bakogeorgos, Vassilis Georgoulias
Chemotherapy-induced peripheral neuropathy (CIPN), a common adverse effect of several chemotherapeutic agents, has a significant impact on quality of life and may even compromise treatment efficacy, requiring chemotherapy dose reduction or discontinuation. CIPN is predominantly related with sensory rather than motor symptoms and the most common related cytotoxic agents are platinum compounds, taxanes and vinca alkaloids. CIPN symptoms may resolve after treatment cessation, but they can also be permanent and continue for years...
November 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28862047/new-surgical-approaches-for-clinically-high-risk-or-metastatic-prostate-cancer
#19
REVIEW
Paolo Dell'Oglio, Armando Stabile, Giorgio Gandaglia, Emanuele Zaffuto, Nicola Fossati, Marco Bandini, Nazareno Suardi, Pierre I Karakiewicz, Shahrokh F Shariat, Francesco Montorsi, Alberto Briganti
A considerable number of individuals with prostate cancer (PCa) still harbor locally-advanced and metastatic disease. Although such men were initially not considered eligible for local treatment, the role of radical prostatectomy (RP) has been recently reassessed. Areas covered: This review analyses currently published evidences regarding new surgical approaches for clinically high-risk PCa individuals, as well as the role of cytoreductive surgery in the metastatic setting. The role of robot-assisted radical prostatectomy (RARP) and extended pelvic lymph node dissection will be evaluated with regards to perioperative, oncologic, as well as functional outcomes...
November 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28862039/application-of-the-american-society-of-clinical-oncology-frameworks-to-compare-tyrosine-kinase-inhibitors-used-in-first-line-treatment-of-metastatic-renal-cell-carcinoma-had-we-solved-the-mystery
#20
REVIEW
Sherif Hassanien Ahmed, Noha Elbaghdady, Mohamed Alorabi
The approval of multiple biological therapies as a first line treatment for metastatic renal cell carcinoma (mRCC) in the last decade have made the selection of the best treatment between these drugs, especially tyrosine kinase inhibitors (TKIs), a great challenge to oncologists and patients. The four TKIs recommended by the National Comprehensive Cancer Network guidelines in this setting have a relatively similar mechanism of action and analogical adverse events. Areas covered: In this article, the two published American Society of Clinical Oncology frameworks are applied to calculate the net health benefits of the four TKIs used as the first line in mRCC and this was balanced against their monthly cost...
November 2017: Expert Review of Anticancer Therapy
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