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Journal of Medical and Biological Engineering

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https://www.readbyqxmd.com/read/29861706/effect-of-collagen-polycaprolactone-nanofibers-matrix-coating-on-the-in-vitro-cytocompatibility-and-in-vivo-bone-responses-of-titanium
#1
Morshed Khandaker, Shahram Riahinezhad, Fariha Sultana, Tracy Morris, Roman Wolf, Melville Vaughan
The objective of this study was to improve the biomechanical performance of titanium (Ti) using a biocompatible electrospun nanofiber matrix. The study is based on the hypothesis that coating a Ti surface with a nanofiber matrix (NFM) made of collagen (CG) and polycaprolactone (PCL) electrospun nanofibers could increase the mechanical fixation of Ti/bone by improving the surface and cytocompatibility properties of Ti. This study prepared Ti samples with and without CG-PCL NFM coatings. This study determined the in vitro effects of each group of Ti samples on the surface topography and cytocompatibility (osteoblast cell adhesion, proliferation, mineralization and protein adsorption) properties...
April 2018: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/30220902/web-based-experience-sharing-platform-on-medical-device-incidents-for-clinical-engineers-in-hospitals
#2
Mei-Fen Chen, Cheng-Lun Tsai, Yung-Hsin Chen, Yu-Wen Huang, Cheng-Ning Wu, Ching Chou, Chia-Hung Chien, Pei-Weng Tu, Tsair Kao, Kang-Ping Lin
The aim of this study was to establish a web-based platform for exchanging medical device management and maintenance experiences to enhance the professional competency of clinical engineers (CEs), which ensures the quality of medical devices and increases patients' satisfaction with medical services. Medical devices play an essential role in diagnosis and disease management. CEs are responsible for providing functional medical devices that contribute worthwhile functions to a medical service to improve patients' health and safety...
2018: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/30220901/strength-analyses-of-screws-for-femoral-neck-fractures
#3
Karel Frydrýšek, Milan Šír, Leopold Pleva
This article represents a multidisciplinary approach to biomechanics (engineering + medicine) in the field of "collum femoris" fractures. One possible treatment method for femoral neck fractures, especially for young people, is the application of cancellous (i.e. lag or femoral) screws (with full or cannulated cross-section) made of Ti6Al4V or stainless steel. This paper therefore aims to offer our own numerical model of cancellous screws together with an assessment of them. The new, simple numerical model presented here is derived together with inputs and boundary conditions and is characterized by rapid solution...
2018: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/30100829/comparative-biomechanical-analysis-of-stress-strain-state-of-the-elbow-joint-after-displaced-radial-head-fractures
#4
Sergey Strafun, Ievgen Levadnyi, Vasily Makarov, Jan Awrejcewicz
Radial head fractures are becoming a major public health problem and are an increasingly important target for both clinical and mechanical researchers. In this work, comparative biomechanical analyses of the stress-strain state of a healthy elbow joint and elbow joints with radial head compression from 2 to 5 mm due to injury are performed. Three-dimensional models of the elbow joint with cartilage surfaces and ligaments were constructed based on the results of computed tomography. This study is focused on an elbow joint range of motion ranging from 0° to 120° flexion...
2018: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/30100828/finite-element-analysis-of-impact-for-helmeted-and-non-helmeted-head
#5
Ievgen Levadnyi, Jan Awrejcewicz, Yan Zhang, Márcio Fagundes Goethel, Yaodong Gu
This study investigated the influence of human head impact on the severity of traumatic brain injury. Simulation of the dynamic impact of a human head was performed using FEM (finite element method) and employing HIC (Head Injury Criterion). The study of traumatic brain injury included impacts with the occiput, temporal, forehead, and parietal part of the head, and the impact velocity at the surface ranged from 1 to 7 m/s. The following characteristics were considered and analyzed in the simulation: duration of the impact, intracranial pressure, HIC, and change in accelerations at the center of gravity of the brain...
2018: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29670502/analysis-of-big-data-in-gait-biomechanics-current-trends-and-future-directions
#6
Angkoon Phinyomark, Giovanni Petri, Esther Ibáñez-Marcelo, Sean T Osis, Reed Ferber
The increasing amount of data in biomechanics research has greatly increased the importance of developing advanced multivariate analysis and machine learning techniques, which are better able to handle "big data". Consequently, advances in data science methods will expand the knowledge for testing new hypotheses about biomechanical risk factors associated with walking and running gait-related musculoskeletal injury. This paper begins with a brief introduction to an automated three-dimensional (3D) biomechanical gait data collection system: 3D GAIT, followed by how the studies in the field of gait biomechanics fit the quantities in the 5 V's definition of big data: volume, velocity, variety, veracity, and value...
2018: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29213224/pro-arrhythmogenic-effects-of-the-v141m-kcnq1-mutation-in-short-qt-syndrome-and-its-potential-therapeutic-targets-insights-from-modeling
#7
Hsiang-Chun Lee, Yoram Rudy, Hongwu Liang, Chih-Chieh Chen, Ching-Hsing Luo, Sheng-Hsiung Sheu, Jianmin Cui
Gain-of-function mutations in the pore-forming subunit of IKs channels, KCNQ1, lead to short QT syndrome (SQTS) and lethal arrhythmias. However, how mutant IKs channels cause SQTS and the possibility of IKs -specific pharmacological treatment remain unclear. V141M KCNQ1 is a SQTS associated mutation. We studied its effect on IKs gating properties and changes in the action potentials (AP) of human ventricular myocytes. Xenopus oocytes were used to study the gating mechanisms of expressed V141M KCNQ1/KCNE1 channels...
October 2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/28824352/effects-of-carpal-tunnel-syndrome-on-force-coordination-and-muscle-coherence-during-precision-pinch
#8
Szu-Ching Lu, Kaihua Xiu, Ke Li, Tamara L Marquardt, Peter J Evans, Zong-Ming Li
Carpal tunnel syndrome (CTS), caused by entrapment of the median nerve in the carpal tunnel, impairs hand function including dexterous manipulation. The purpose of this study was to investigate the effects of CTS on force coordination and muscle coherence during low-intensity sustained precision pinch while the wrist assumed different postures. Twenty subjects (10 CTS patients and 10 asymptomatic controls) participated in this study. An instrumented pinch device was used to measure the thumb and index finger forces while simultaneously collecting surface electromyographic activities of the abductor pollicis brevis (APB) and first dorsal interosseous (FDI) muscles...
June 2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/30220900/respiratory-rate-estimation-by-using-ecg-impedance-and-motion-sensing-in-smart-clothing
#9
Chien-Lung Shen, Tzu-Hao Huang, Po-Chun Hsu, Ya-Chi Ko, Fen-Ling Chen, Wei-Chun Wang, Tsair Kao, Chia-Tai Chan
The needs for light-weight and soft smart clothing in homecare have been rising since the past decade. Many smart textile sensors have been developed and applied to automatic physiological and user-centered environmental status recognition. In the present study, we propose wearable multi-sensor smart clothing for homecare monitoring based on an economic fabric electrode with high elasticity and low resistance. The wearable smart clothing integrated with heterogeneous sensors is capable to measure multiple human biosignals (ECG and respiration), acceleration, and gyro information...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29930493/long-term-oral-toxicity-and-anti-osteoporotic-effect-of-sintered-dicalcium-pyrophosphate-in-rat-model-of-postmenopausal-osteoporosis
#10
Yuh-Feng Tsai, Li-Ho Hsu, Chang-Chin Wu, Wei-Hua Cai, Kai-Chiang Yang, Fang-Yu Fan
Sintered dicalcium pyrophosphate (SDCP), a synthetic pyrophosphate analog, has shown potential for the management of osteoporosis. The long-term oral toxicity and anti-osteoporotic effect of SDCP in a postmenopausal osteoporosis rat model were evaluated in this study. SDCP was orally administered to bilateral ovariectomized (OVX) Wistar rats at a dose of 0.75 mg/kg daily for 24 weeks following by 2 weeks of observation. There were no abnormal findings in clinical signs of toxicity, food consumption, body weight, blood examination, necropsy, and histological inspection attributable to the ingestion of SDCP...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29755307/adopting-quaternion-wavelet-transform-to-fuse-multi-modal-medical-images
#11
Peng Geng, Xiuming Sun, Jianhua Liu
Medical image fusion plays an important role in clinical applications such as image-guided surgery, image-guided radiotherapy, noninvasive diagnosis, and treatment planning. In this paper, we propose a novel multi-modal medical image fusion method based on simplified pulse-coupled neural network and quaternion wavelet transform. The proposed fusion algorithm is capable of combining not only pairs of computed tomography (CT) and magnetic resonance (MR) images, but also pairs of CT and proton-density-weighted MR images, and multi-spectral MR images such as T1 and T2...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29541015/preclinical-biokinetic-modelling-of-tc-99m-radiophamaceuticals-obtained-from-semi-automatic-image-processing
#12
Luz G Cornejo-Aragón, Clara L Santos-Cuevas, Blanca E Ocampo-García, Isaac Chairez-Oria, Lorenza Diaz-Nieto, Janice García-Quiroz
The aim of this study was to develop a semi automatic image processing algorithm (AIPA) based on the simultaneous information provided by X-ray and radioisotopic images to determine the biokinetic models of Tc-99m radiopharmaceuticals from quantification of image radiation activity in murine models. These radioisotopic images were obtained by a CCD (charge couple device) camera coupled to an ultrathin phosphorous screen in a preclinical multimodal imaging system (Xtreme, Bruker). The AIPA consisted of different image processing methods for background, scattering and attenuation correction on the activity quantification...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29541014/classification-of-normal-ictal-and-inter-ictal-eeg-via-direct-quadrature-and-random-forest-tree
#13
Enas Abdulhay, Maha Alafeef, Arwa Abdelhay, Areen Al-Bashir
This paper presents an accurate nonlinear classification method that can help physicians diagnose seizure in electroencephalographic (EEG) signal characterized by a disturbance in temporal and spectral content. This is accomplished by applying four steps. First, different EEG signals containing healthy, ictal and seizure-free (inter-ictal) activities are decomposed by empirical mode decomposition method. The instantaneous amplitudes and frequencies of resulted bands (intrinsic mode functions, IMF) are then tracked by the direct quadrature method (DQ)...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29541013/minimizing-a-wireless-passive-lc-tank-sensor-to-monitor-bladder-pressure-a-simulation-study
#14
Jacob Melgaard, Johannes J Struijk, Nico J M Rijkhoff
In this simulation study, a wireless passive LC-tank sensor system was characterized. Given the application of continuous bladder monitoring, a specific system was proposed in terms of coil geometries and electronic circuitry. Coupling coefficients were spatially mapped by simulation, as a function of both coil distance, and longitudinal and transverse translation of the sensor relative to the antenna. Further, two interrogation schemes were outlined. One was an auto-balancing bridge for computing the sensor-system impedance...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29541012/the-great-need-of-a-biomechanical-based-approach-for-surgical-methods-of-giant-cell-tumor-a-critical-review
#15
REVIEW
Azadeh Ghouchani, Gholamreza Rouhi
There are many unanswered questions about giant cell tumor (GCT) treatment and not enough attention is paid to the biomechanics of the current treatment methods. Treatment methods have not changed much, and the best method remains controversial to some degree, due to the lack of adequate clinical and biomechanical investigations. Biomechanical tests, including in vitro mechanical experiments combined with finite element analysis, are very helpful in assessing the efficiency of the surgical methods employed and in determining the optimal method of surgery...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29541011/measured-pet-data-characterization-with-the-negative-binomial-distribution-model
#16
Maria Filomena Santarelli, Vincenzo Positano, Luigi Landini
Accurate statistical model of PET measurements is a prerequisite for a correct image reconstruction when using statistical image reconstruction algorithms, or when pre-filtering operations must be performed. Although radioactive decay follows a Poisson distribution, deviation from Poisson statistics occurs on projection data prior to reconstruction due to physical effects, measurement errors, correction of scatter and random coincidences. Modelling projection data can aid in understanding the statistical nature of the data in order to develop efficient processing methods and to reduce noise...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/29541010/common-methodology-for-cardiac-and-ocular-artifact-suppression-from-eeg-recordings-by-combining-ensemble-empirical-mode-decomposition-with-regression-approach
#17
Rajesh Patel, K Gireesan, S Sengottuvel, M P Janawadkar, T S Radhakrishnan
Electroencephalography (EEG) is a non-invasive way of recording brain activities, making it useful for diagnosing various neurological disorders. However, artifact signals associated with eye blinks or the heart spread across the scalp, contaminating EEG recordings and making EEG data analysis difficult. To solve this problem, we implement a common methodology to suppress both cardiac and ocular artifact signal, by correlating the measured contaminated EEG signals with the clean reference electro-oculography (EOG) and electrocardiography (EKG) data and subtracting the scaled EOG and EKG from the contaminated EEG recording...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/28867992/analysis-of-locking-self-taping-bone-screws-for-angularly-stable-plates
#18
Radek Čada, Karel Frydrýšek, František Sejda, Jiří Demel, Leopold Pleva
Paper focuses on biomechanics, specifically on locking cortical bone screws in angularly stable plates used for the treatment of bone fractures in the medical fields of traumatology and orthopaedics. During extraction of titanium-alloy implants, problems are encountered in an effort to loosen some locking bone screws from the locking holes of an angularly stable plate and the subsequent stripping of the internal hexagon of the screw head. The self-locking of the screw-plate threaded joint was verified by calculation and the effect of the angle of the thread on the head of the locking cortical bone screw on self-locking was evaluated...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/28867991/video-voiding-device-for-diagnosing-lower-urinary-tract-dysfunction-in-men
#19
Mehdi Shokoueinejad, Rayan Alkashgari, Hisham A Mosli, Nazeeh Alothmany, Jacob M Levin, John G Webster
We introduce a novel diagnostic Visual Voiding Device (VVD), which has the ability to visually document urinary voiding events and calculate key voiding parameters such as instantaneous flow rate. The observation of the urinary voiding process along with the instantaneous flow rate can be used to diagnose symptoms of Lower Urinary Tract Dysfunction (LUTD) and improve evaluation of LUTD treatments by providing subsequent follow-up documentations of voiding events after treatments. The VVD enables a patient to have a urinary voiding event in privacy while a urologist monitors, processes, and documents the event from a distance...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/28867990/ecg-parameters-for-malignant-ventricular-arrhythmias-a-comprehensive-review
#20
REVIEW
Satria Mandala, Tham Cai Di
Many studies showed electrocardiogram (ECG) parameters are useful for predicting fatal ventricular arrhythmias (VAs). However, the studies have several shortcomings. Firstly, all studies lack of effective way to present behavior of various ECG parameters prior to the occurrence of the VAs. Secondly, they also lack of discussion on how to consider the parameters as abnormal. Thirdly, the reports do not include approaches to increase the detection accuracy for the abnormal patterns. The purpose of this study is to address the aforementioned issues...
2017: Journal of Medical and Biological Engineering
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