journal
MENU ▼
Read by QxMD icon Read
search

Best Practice & Research. Clinical Anaesthesiology

journal
https://www.readbyqxmd.com/read/30322466/adjunct-medications-for-peripheral-and-neuraxial-anesthesia
#1
REVIEW
Patrick Ifesinachi Emelife, Matthew R Eng, Bethany L Menard, Andrew S Myers, Elyse M Cornett, Richard D Urman, Alan D Kaye
Regional and neuraxial anesthesia can provide a safer perioperative experience, greater satisfaction, reduced opioid consumption, and reduction of pain, while minimizing side effects. Ultrasound technology has aided clinicians in depositing local anesthetic medication in precise proximity to targeted peripheral nerves. There are a plethora of adjuvants that have been utilized to prolong local anesthetic actions and enhance effects in peripheral nerve blocks. This manuscript describes the current state of the use of adjuncts, e...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322465/pharmacogenomics-precision-medicine-and-implications-for-anesthesia-care
#2
REVIEW
Alan D Kaye, Thomas Mahakian, Aaron J Kaye, Andrew A Pham, Brendon M Hart, Sonja Gennuso, Elyse M Cornett, Rodney A Gabriel, Richard D Urman
The study of how individual genetic differences, known as polymorphisms, change the pharmacokinetics and pharmacodynamics of drugs is called pharmacogenomics. As the field of pharmacogenetics grows and continues to identify genetic polymorphisms, it is promising that the unmet need in this patient population may soon be addressed with personalized drug therapy based on the patient's genetic composition. Although encouraging, pharmacogenomic testing is underutilized in the United States and is often not covered by insurance companies...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322464/perioperative-pharmacology-new-evidence-agents-and-concepts-impacting-perioperative-practice
#3
EDITORIAL
Richard D Urman
No abstract text is available yet for this article.
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322463/pulmonary-vasodilators-latest-evidence-and-outcomes-in-the-perioperative-setting
#4
REVIEW
Charles J Fox, Elyse M Cornett, Brendon M Hart, Aaron J Kaye, Shilpadevi S Patil, Michelle Carroll Turpin, Angelica Valdez, Richard D Urman, Alan D Kaye
Numerous conditions give rise to pulmonary arterial hypertension (PAH), with most of them being idiopathic. Signs and symptoms are generally difficult to recognize initially because they present as nonspecific and typically are mistaken for age-related physiological processes or alternate medical conditions. Many advances have been made toward PAH-specific therapies that have led to advanced clinical management of the disease. The present investigation describes new pulmonary vasodilator agents that are currently available or under development that could impact perioperative management...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322462/new-antihypertensive-medications-and-clinical-implications
#5
REVIEW
D Wong, P N W Tsai, K Y Ip, M G Irwin
Hypertension remains a global public health issue and is a leading preventable risk factor for many causes of mortality and morbidity. Although it is generally managed as an outpatient chronic disease, anaesthetists will inevitably encounter patients with hypertension, ranging from undiagnosed asymptomatic to chronic forms with end-organ damage(s). An understanding of perioperative management of anti-hypertensive pharmacotherapy is crucial. Although many drugs are familiar, new drug groups that have relevance for blood pressure control and perioperative care have evolved in recent years...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322461/newer-propofol-ketamine-and-etomidate-derivatives-and-delivery-systems-relevant-to-anesthesia-practice
#6
REVIEW
N Hulsman, M W Hollmann, B Preckel
Drug discovery is the cornerstone of developments in the field of anesthesia. Each year, new drugs enter the market and possibly change clinical practice. The development of new anesthetics can be divided into two groups. One strategy is the discovery of a new type of drug with unique molecular structure, better clinical properties, and lesser side effects than the already existing drugs. Another strategy is changing the molecular structure of current clinically available anesthetics to create new drugs with better pharmacokinetic and pharmacodynamic properties...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322460/neuromuscular-blockers-and-reversal-agents-and-their-impact-on-anesthesia-practice
#7
REVIEW
Zdravka Zafirova, Allison Dalton
Neuromuscular blockers have long been an intricate part of the anesthesia regimen. The scientific progress in pharmacology and physiology has strengthened their clinical relevance, has helped to delineate with precision their medical role, and has enhanced the safety and effectiveness of their use. New frontiers in research will define further the role of these agents in modern anesthesia practice and guide their expanding and discrete clinical applications.
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322459/perioperative-implications-of-common-and-newer-psychotropic-medications-used-in-clinical-practice
#8
REVIEW
Alan D Kaye, Ryan J Kline, Elliott R Thompson, Aaron J Kaye, Justin A Terracciano, Harish B Siddaiah, Richard D Urman, Elyse M Cornett
Psychotropic medications are widely prescribed by clinicians as both primary therapy for a variety of psychiatric and neurodegenerative diseases and as adjunctive analgesics for use in the perioperative period. It is critical to understand various modes of action, drug-drug interactions, side effects, and clinical implications. Health care providers must understand how these medications interact with anesthetics, as well as other drugs used in perioperative care. We review relevant psychiatric and neurodegenerative diseases, psychotropic medications used to treat them, and how these medications interact with anesthetics and drugs used in perioperative care...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322458/new-local-anesthetics
#9
REVIEW
Jarna Shah, Effrossyni Gina Votta-Velis, Alain Borgeat
Local anesthetics are used for performing various regional anesthesia techniques to provide intraoperative anesthesia and analgesia, as well as for the treatment of acute and chronic pain. Older medications such as lidocaine and bupivacaine as well as newer ones such as mepivacaine and ropivacaine are being used successfully for decades. Routes of administration include neuraxial, perineural, intravenous, various infiltrative approaches, topical, and transdermal. There are new innovations with the use of older local anesthetics in a novel manner, in addition to the development and use of new formulations...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322457/new-anticoagulants-reversal-agents-and-clinical-considerations-for-perioperative-practice
#10
REVIEW
Brendon M Hart, Stephane M Ferrell, Mark W Motejunas, Lauren A Bonneval, Elyse M Cornett, Richard D Urman, Alan D Kaye
There are several new anticoagulants on the market that will impact perioperative care, including the use of these anticoagulant drugs in the setting of regional anesthesia. The ideal pharmacological agent would prevent pathological thrombosis and allow for a normal response to vascular injury to limit bleeding. At present, all antithrombotic agents have increased bleeding risk as their main side effect. We describe the different categories of drugs, e.g., antiplatelet, anticoagulant, and thrombolytic, with particular emphasis on the new drugs that have been introduced into the market...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322456/new-benzodiazepines-for-sedation
#11
REVIEW
Elyse M Cornett, Matthew B Novitch, Andrew J Brunk, Kelly S Davidson, Bethany L Menard, Richard D Urman, Alan D Kaye
There are currently new drugs being developed that have benzodiazepine properties. This review will examine remimazolam, 3-hydroxyphenazapam, adinazolam, clonazolam, and deschloroetizolam as well as other novel agents. All benzodiazepines are protein bound and only moderately lipid soluble. In addition to their baseline properties, they can be enzymatically broken down into active metabolites. The mechanism of action of these medications is related to polysynaptic pathway inhibition via direct interaction with GABA and modifiable chloride channels...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322455/what-is-new-in-the-battle-against-postoperative-nausea-and-vomiting
#12
REVIEW
Vahé S Tateosian, Katelynn Champagne, Tong J Gan
The issue of postoperative nausea and vomiting (PONV) still poses a significant burden on our patients. Although rarely associated with a life-threatening condition, it is consistently considered as one of the most undesirable side effects of surgery and anesthesia. There are well-established risk factors for the development of PONV that include patient-related factors, anesthetic technique, use of volatile anesthetics, use of nitrous oxide, duration of anesthesia, opioid administration, and type of surgery...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322454/new-opioid-receptor-modulators-and-agonists
#13
REVIEW
Alan D Kaye, Elyse M Cornett, Shilpa S Patil, Sonja A Gennuso, Matthew M Colontonio, Dustin R Latimer, Aaron J Kaye, Richard D Urman, Nalini Vadivelu
There has been significant research to develop an ideal synthetic opioid. Opioids with variable properties possessing efficacy and with reduced side effects have been synthesized when compared to previously used agents. An opioid modulator is a drug that can produce both agonistic and antagonistic effects by binding to different opioid receptors and therefore cannot be classified as one or the other alone. These compounds can differ in their structures while still possessing opioid-mediated actions. This review will discuss TRV130 receptor modulators and other novel opioid receptor modulators, including Mitragyna "Kratom," Ignavine, Salvinorin-A, DPI-289, UFP-505, LP1, SKF-10,047, Cebranopadol, Naltrexone-14-O-sulfate, and Naloxegol...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322453/update-on-nitrous-oxide-and-its-use-in-anesthesia-practice
#14
REVIEW
Zdravka Zafirova, Colin Sheehan, Leila Hosseinian
Nitrous oxide (N2 O) is an anesthetic and analgesic gas with a long history of medical applications. It acts on multiple supraspinal and spinal targets and has utility in a wide range of clinical situations. The relative safety, low incidence, and acuity of adverse effects of N2 O, along with the ability to be administered by trained medical providers with varying clinical backgrounds, as well as self-administered by patients, assure its persistent and expanding role in clinical practice.
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30322452/procedure-specific-pain-management-prospect-an-update
#15
REVIEW
Brian Lee, Stephan A Schug, Girish P Joshi, Henrik Kehlet
Post-operative pain management protocols may be optimised by examining procedure-specific evidence and outcomes. This recognition led to the formation of the PROcedure-SPECific Pain ManagemenT (PROSPECT) collaboration of anaesthesiologists and surgeons. The aim of PROSPECT is to provide practical and evidence-based recommendations to prevent and treat post-operative pain after specific surgical procedures, thereby overcoming the limitations of generic, non-specific guidelines. Updates in the methodology of PROSPECT in 2017 have placed an increased emphasis on the clinical relevance of studies, including a focus on interventions in the context of multimodal analgesia strategies and consideration of risks and benefits of interventions in specific surgical settings...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30049339/how-anesthetists-manage-growing-demands-with-dwindling-resources-in-german-university-hospitals-overview-and-outlook
#16
REVIEW
Juergen Hinkelmann, Joachim Hasebrook, Christiane Goeters, Klaus Hahnenkamp
As a central service provider in medical care, anesthetists manage the growing demand on medical services, thereby increasing specialization and patient morbidity. Various indicators and measurements have been used to match staff capacity, competence, and workload. It remains unclear whether the problems are due to real shortages or "just" to a wrong distribution. Medical services, service development, infrastructure, capacity, and competences of medical staff of 15 departments of anesthesiology at German university hospitals were compared...
March 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30049338/moving-towards-a-competence-centre-for-geriatric-medicine-and-care-quality-management-and-human-resource-management-as-major-support-factors
#17
REVIEW
Kerstin Löffler, Judith Goldgruber, Gerd Hartinger
Changed employment models, an ageing workforce and demands of new generations are challenging healthcare facilities to go down new paths. Never before have well-qualified staff been as highly sought after within the medical and nursing care sector as they are today. For many years, the Geriatric Health Care Centres of the city of Graz (GGZ)-a large regional health care provider with more than 650 staff across five locations-has focused a lot on the topic of competence management, facilitation of specialist and management careers in nursing and medicine as well as the optimal mix of skills and grades in staffing...
March 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30049337/integrating-cross-border-emergency-medicine-systems-securing-future-preclinical-medical-workforce-for-remote-medical-services
#18
REVIEW
Tomasz Ucinski, Grzegorz Dolata, Robert Hełminiak, Lutz Fischer, Steffen Fleßa, Bernhard Brehmer, Armin Viert, Volker Grundmann, Sebastian Rehberg, Kathrin Krügel, Maud Partecke, Peter Brinkrolf, Klaus Hahnenkamp, Konrad Meissner
The European Union intends to enable its citizens to interact across borders in relevant areas of society and culture to further integrate neighboring regions. Medicine has not been at the core of recent EU-funded efforts in central Europe, partially due to significant differences in health care administration, delivery, reimbursement, and culture. However, impeding changes in social structure and centralization of specialized care warrant changes in preclinical administration of medical care, which are already transforming practices across developed countries in central Europe...
March 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30049336/securing-the-future-anaesthetic-workforce
#19
REVIEW
Chris Carey
A suitably skilled workforce that is of an appropriate size is essential for the provision of healthcare services. Anaesthetists play an essential role in a wide range of clinical areas, and effective workforce planning and training are essential in maintaining service provision. Workforce planning requires consideration of a number of different factors related to the workforce itself and services that are required. Long-term predictions must be made, as the process of training a consultant workforce with the flexibility to adapt to changing services takes many years...
March 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30049335/improving-female-physician-s-careers-in-academic-medicine-chances-and-challenges
#20
REVIEW
Bettina Pfleiderer, Marina Bortul, Silvia Palmisano, Sibyll Rodde, Joachim Hasebrook
University hospitals are involved in the care of critically ill patients, pregraduate and postgraduate education, and medical research with an increasing demand on physicians due to a higher burden of disease. The number of female physicians is increasing; however, young female physicians are less willing to work at university hospitals under the given conditions. They often do not find appropriate working conditions in mostly hierarchically structured university hospitals. Institutional structures involuntarily erect barriers against the recruitment, retention, and career progression of women...
March 2018: Best Practice & Research. Clinical Anaesthesiology
journal
journal
39752
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"