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Molecular Imaging

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https://www.readbyqxmd.com/read/28893116/imaging-hepatocellular-carcinoma-with-68-ga-citrate-pet-first-clinical-experience
#1
Carina Mari Aparici, Spencer C Behr, Youngho Seo, R Kate Kelley, Carlos Corvera, Kenneth T Gao, Rahul Aggarwal, Michael J Evans
While cross-sectional imaging with computed tomography (CT) and magnetic resonance imaging is the primary method for diagnosing hepatocellular carcinoma (HCC), they provide little biological insight into this molecularly heterogeneous disease. Nuclear imaging tools that can detect molecular subsets of tumors could greatly improve diagnosis and management of HCC. To this end, we conducted a patient study to determine whether HCC can be resolved using (68)Ga-citrate positron emission tomography (PET). One patient with recurrent HCC was injected with 300 MBq of (68)Ga-citrate and imaged with PET/CT 249 minutes post injection...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28884622/ex-vivo-and-in-vivo-noninvasive-imaging-of-epidermal-growth-factor-receptor-inhibition-on-colon-tumorigenesis-using-activatable-near-infrared-fluorescent-probes
#2
Shengli Ding, Randall E Blue, Emily Moorefield, Hong Yuan, Pauline K Lund
BACKGROUND: Near-infrared fluorescence (NIRF) imaging combined with enzyme-activatable NIRF probes has yielded promising results in cancer detection. OBJECTIVE: To test whether 3-dimensional (3-D) noninvasive in vivo NIRF imaging can detect effects of epidermal growth factor receptor (EGFR) inhibitor on both polypoid and flat tumor load in azoxymethane (AOM)-induced colon tumors or tumors in Apc(Min/+) mice. METHODS: The AOM-injected KK-HIJ mice received EGFR inhibitor diet or chow diet...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28877656/longitudinal-evaluation-of-myocardial-fatty-acid-and-glucose-metabolism-in-fasted-and-nonfasted-spontaneously-hypertensive-rats-using-micropet-ct
#3
Jennifer S Huber, Andrew M Hernandez, Mustafa Janabi, James P O'Neil, Kathleen M Brennan, Stephanie T Murphy, Youngho Seo, Grant T Gullberg
Using longitudinal micro positron emission tomography (microPET)/computed tomography (CT) studies, we quantified changes in myocardial metabolism and perfusion in spontaneously hypertensive rats (SHRs), a model of left ventricular hypertrophy (LVH). Fatty acid and glucose metabolism were quantified in the hearts of SHRs and Wistar-Kyoto (WKY) normotensive rats using long-chain fatty acid analog (18)F-fluoro-6-thia heptadecanoic acid ((18)F-FTHA) and glucose analog (18)F-fluorodeoxyglucose ((18)F-FDG) under normal or fasting conditions...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28877655/developing-a-strategy-for-interventional-molecular-imaging-of-oxidized-low-density-lipoprotein-in-atherosclerosis
#4
Samata S Pandey, Dorian O Haskard, Ramzi Y Khamis
The identification of vulnerable coronary artery atherosclerotic plaques offers the prospect of either localized or systematic therapeutic targeting in order to prevent myocardial infarction. Molecular imaging of atherosclerosis adds to morphological imaging by focusing on the immunobiology hidden in and behind the endothelium and therefore may be able to improve the identification of prospective culprit lesions. Our focus has been on identifying arterial accumulation of oxidized low-density lipoprotein (oxLDL) by exploiting advances in knowledge of vascular pathobiology...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28856922/detection-and-delineation-of-oral-cancer-with-a-parp1-targeted-optical-imaging-agent
#5
Susanne Kossatz, Wolfgang Weber, Thomas Reiner
More sensitive and specific methods for early detection are imperative to improve survival rates in oral cancer. However, oral cancer detection is still largely based on visual examination and histopathology of biopsy material, offering no molecular selectivity or spatial resolution. Intuitively, the addition of optical contrast could improve oral cancer detection and delineation, but so far no molecularly targeted approach has been translated. Our fluorescently labeled small-molecule inhibitor PARPi-FL binds to the DNA repair enzyme poly(ADP-ribose)polymerase 1 (PARP1) and is a potential diagnostic aid for oral cancer delineation...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28856921/near-infrared-intraoperative-imaging-can-successfully-identify-malignant-pleural-mesothelioma-after-neoadjuvant-chemotherapy
#6
Jarrod D Predina, Andrew Newton, Greg Kennedy, M Kenneth Lee, Sunil Singhal
Malignant pleural mesothelioma is a deadly disease. Complete surgical resection provides patients with the best opportunity for long-term survival. Unfortunately, identification of disease during resection can be challenging. In this report, we describe successful intraoperative utilization of the near-infrared imaging agent, indocyanine green, to help the surgeon identify malignant disease in a patient with malignant pleural mesothelioma who had previously received neoadjuvant chemotherapy. This technology may ultimately enhance the thoracic surgeon's ability to identify small disease deposits at the time of resection...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28849712/combination-of-fluorescence-guided-surgery-with-photodynamic-therapy-for-the-treatment-of-cancer
#7
Jun He, Leping Yang, Wenjun Yi, Wentao Fan, Yu Wen, Xiongying Miao, Li Xiong
Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional medical imaging modalities, such as its safety, effectiveness, and suitability for real-time imaging in the operating room. Recent advancements in contrast agents and intraoperative fluorescence imaging devices have led to a greater potential for intraoperative fluorescence imaging in clinical applications...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28849698/imaging-neurotensin-receptor-in-prostate-cancer-with-64-cu-labeled-neurotensin-analogs
#8
Huaifu Deng, Hui Wang, He Zhang, Mengzhe Wang, Ben Giglio, Xiaofen Ma, Guihua Jiang, Hong Yuan, Zhanhong Wu, Zibo Li
INTRODUCTION: Neurotensin receptor 1 (NTR-1) is expressed and activated in prostate cancer cells. In this study, we explore the NTR expression in normal mouse tissues and study the positron emission tomography (PET) imaging of NTR in prostate cancer models. MATERIALS AND METHODS: Three (64)Cu chelators (1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid [DOTA], 1,4,7-triazacyclononane-N,N',N″-triacetic acid [NOTA], or AmBaSar) were conjugated to an NT analog...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28730928/feasibility-of-na-18-f-pet-ct-and-mri-for-noninvasive-in-vivo-quantification-of-knee-pathophysiological-bone-metabolism-in-a-canine-model-of-post-traumatic-osteoarthritis
#9
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
PURPOSE: To assess and quantify by molecular imaging knee osseous metabolic changes serially in an in vivo canine model of posttraumatic osteoarthritis (PTOA) of the knee utilizing sodium fluoride (Na(18)F) positron emission tomography (PET)/computed tomography (CT) coregistered with magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sodium fluoride PET imaging of 5 canines was performed prior to anterior cruciate ligament transection (ACLT) and 2 times post-ACLT (3 and 12 weeks)...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28707500/noninvasive-imaging-of-immune-checkpoint-ligand-pd-l1-in-tumors-and-metastases-for-guiding-immunotherapy
#10
Samit Chatterjee, Wojciech G Lesniak, Sridhar Nimmagadda
Immunotherapy holds great promise in cancer treatment. The challenges in advancing immunotherapies lie in patient stratification and monitoring therapy. Noninvasive detection of immune checkpoint ligand PD-L1 can serve as an important biomarker for guidance and monitoring of immunotherapy. Here in, we provide an overview of our efforts to develop clinically translatable PD-L1-specific imaging agents for quantitative and real-time assessment of PD-L1 expression in tumor microenvironment.
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654388/commentary-on-a-microfluidic-platform-to-design-crosslinked-hyaluronic-acid-nanoparticles-chanps-for-enhanced-mri
#11
Maria Russo, Paolo Bevilacqua, Paolo Antonio Netti, Enza Torino
Strategies to enhance the relaxometric properties of gadolinium (Gd)-based contrast agents (CAs) for magnetic resonance imaging (MRI), without the chemical modification of chelates, have recently had a strong impact on the diagnostic field. We have taken advantage of the interaction between Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) and the hydrogel structure of hyaluronic acid to design cross-linked hyaluronic acid nanoparticles down to 35 nm for use in MRI applications. The proposed bioformulations enable the control of the relaxometric properties of CAs, thus boosting the relaxation rate of T1...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654387/phosphatidylserine-targeted-nanotheranostics-for-brain-tumor-imaging-and-therapeutic-potential
#12
Lulu Wang, Amyn A Habib, Akiva Mintz, King C Li, Dawen Zhao
Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. However, this PS asymmetry is found disruptive in many tumor vascular endothelial cells. We discuss the underlying mechanisms for PS asymmetry maintenance in normal cells and its loss in tumor cells. The specificity of PS exposure in tumor vasculature but not normal blood vessels may establish it a useful biomarker for cancer molecular imaging. Indeed, utilizing PS-targeting antibodies, multiple imaging probes have been developed and multimodal imaging data have shown their high tumor-selective targeting in various cancers...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654386/dual-energy-spect-and-the-development-of-peptide-p5-14-for-imaging-amyloidosis
#13
Jonathan S Wall, Stephen J Kennel, Emily B Martin
Amyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic amyloidosis are hampered by the lack of a noninvasive, quantitative method for detecting whole-body amyloid load. We have used a battery of assays including dual-energy SPECT imaging and comparative effectiveness studies in support of translation of a synthetic polybasic peptide, p5+14, as a novel radiotracer for visualization of amyloidosis by molecular imaging...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654385/3d-fusion-framework-for-infarction-and-angiogenesis-analysis-in-a-myocardial-infarct-minipig-model
#14
Xu Zhenzhen, Bo Tao, Yu Li, Jun Zhang, Xiaochao Qu, Feng Cao, Jimin Liang
The combination of different modality images can provide detailed and comprehensive information for the prognostic assessment and therapeutic strategy of patients with ischemic heart disease. In this study, a 3D fusion framework is designed to integrate coronary computed tomography (CT) angiography (CTA), 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]DG) positron emission tomography (PET)/CT, and [(68)Ga]-1,4,7-triazacyclononane-1,4,7-triacetic acid-(Arg-Gly-Asp)2 ([(68)Ga]-NOTA-PRGD2) PET/CT images of the myocardial infarction model in minipigs...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654384/fluorescent-plasmonic-and-radiotherapeutic-properties-of-the-177-lu-dendrimer-aunp-folate-bombesin-nanoprobe-located-inside-cancer-cells
#15
Héctor Mendoza-Nava, Guillermina Ferro-Flores, Flor de María Ramírez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Keila Isaac-Olivé
The integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic-photothermal, therapeutic, and radiotherapeutic potential of (177)Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity ((177)Lu-DenAuNP-folate-bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP-folate-bombesin for optical imaging...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654383/brain-and-brown-adipose-tissue-metabolism-in-transgenic-tg2576-mice-models-of-alzheimer-disease-assessed-using-18-f-fdg-pet-imaging
#16
Robert A Coleman, Christopher Liang, Rima Patel, Sarah Ali, Jogeshwar Mukherjee
OBJECTIVE: Imaging animal models of Alzheimer disease (AD) is useful for the development of therapeutic drugs and understanding AD. Transgenic Swedish hAPPswe Tg2576 mice are a good model of β-amyloid plaques. We report (18)F-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET) imaging of brain and intrascapular brown adipose tissue (IBAT) in transgenic mice 2576 (Tg2576) and wild-type (WT) mice. METHODS: Transgenic Tg2576 mice and WT mice, >18 months were injected intraperitonally with ≈ 25 to 30 MBq (18)F-FDG while awake...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654382/imaging-of-myocardial-ischemia-reperfusion-injury-using-sodium-18-f-fluoride-positron-emission-tomography-computed-tomography-in-rats-and-humans
#17
Hongyoon Choi, Jeong Hee Han, Sue Yeon Lim, Inki Lee, Young-Seok Cho, Eun Ju Chun, Won Woo Lee
Positron emission tomography (PET)/computed tomography (CT) using sodium [(18)F]fluoride (Na[(18)F]F) has been proven to be a promising hot-spot imaging modality for myocardial infarction (MI). We investigated Na[(18)F]F uptake in ischemia-reperfusion injury (IRI) of rats and humans. Sodium [(18)F]fluoride PET/CT was performed in Sprague-Dawley rats that had IRI surgery, and it readily demonstrated prominent Na[(18)F]F uptake in the infarct area post-IRI. Sodium [(18)F]fluoride uptake was matched with negative 2,3,5-triphenyl-2 H-tetrazolium chloride staining results, accompanied by myocardial apoptosis and associated with positive calcium staining results...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654381/preclinical-multimodal-molecular-imaging-using-18-f-fdg-pet-ct-and-mri-in-a-phase-i-study-of-a-knee-osteoarthritis-in-in-vivo-canine-model
#18
Maria I Menendez, Bianca Hettlich, Lai Wei, Michael V Knopp
The aim of this study was to use a multimodal molecular imaging approach to serially assess regional metabolic changes in the knee in an in vivo anterior cruciate ligament transection (ACLT) canine model of osteoarthritis (OA). Five canine underwent ACLT in one knee and the contralateral knee served as uninjured control. Prior, 3, 6, and 12 weeks post-ACLT, the dogs underwent (18)F-fluoro-d-glucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI). The MRI was coregistered with the PET/CT, and 3-dimensional regions of interest (ROIs) were traced manually and maximum standardized uptake values (SUVmax) were evaluated...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654380/targeted-imaging-of-tumor-associated-macrophages-by-cyanine-7-labeled-mannose-in-xenograft-tumors
#19
Chong Jiang, Huawei Cai, Xiaodong Peng, Ping Zhang, Xiaoai Wu, Rong Tian
Mannose receptor is considered as a hallmark of M2-oriented tumor-associated macrophages (TAMs), but its utility in TAMs was rarely reported. Therefore, deoxymannose (DM), a high-affinity ligand of mannose receptor, was labeled with near-infrared dye cyanine 7 (Cy7), and its feasibility of targeted imaging on TAMs was evaluated in vitro and in vivo. The Cy7-DM was synthesized, and its binding affinity with induced TAMs in vitro, whole-body imaging in xenograft tumor mouse model in vivo, and the cellular localization in dissected tissues were evaluated...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654379/multimodal-imaging-of-patients-with-gliomas-confirms-11-c-met-pet-as-a-complementary-marker-to-mri-for-noninvasive-tumor-grading-and-intraindividual-follow-up-after-therapy
#20
Kai R Laukamp, Florian Lindemann, Matthias Weckesser, Volker Hesselmann, Sandra Ligges, Johannes Wölfer, Astrid Jeibmann, Bastian Zinnhardt, Thomas Viel, Michael Schäfers, Werner Paulus, Walter Stummer, Otmar Schober, Andreas H Jacobs
The value of combined L-( methyl-[(11)C]) methionine positron-emitting tomography (MET-PET) and magnetic resonance imaging (MRI) with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspicion of a brain tumor was investigated. In n = 65 patients with histologically verified brain lesions n = 70 MET-PET and MRI (T1-weighted gadolinium-enhanced [T1w-Gd] and fluid-attenuated inversion recovery or T2-weighted [FLAIR/T2w]) examinations were performed. The computer software "visualization and analysis framework volume rendering engine (Voreen)" was used for analysis of extent and intersection of tumor compartments...
January 1, 2017: Molecular Imaging
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