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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/28714751/antidepressant-efficacy-of-electroconvulsive-therapy-is-associated-with-a-reduction-of-the-innate-cellular-immune-activity-in-the-cerebrospinal-fluid-in-patients-with-depression
#1
Laura Kranaster, Carolin Hoyer, Suna S Aksay, J Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
July 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28699376/corrigendum
#2
(no author information available yet)
No abstract text is available yet for this article.
July 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28656803/val66met-polymorphism-association-with-serum-bdnf-and-inflammatory-biomarkers-in-major-depression
#3
Marco Antonio Caldieraro, Madison McKee, Sandra Leistner-Segal, Edgar Arrua Vares, Francyne Kubaski, Lucas Spanemberg, Ana Carolina Brusius-Facchin, Marcelo P Fleck, David Mischoulon
OBJECTIVES: Current evidence supports participation of neurotrophic and inflammatory factors in the pathogenesis of major depressive disorder (MDD). Some studies reported an association between the Val66Met polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene with MDD and peripheral BDNF levels. However, no previous studies have examined the association of this polymorphism with inflammation. The present study assessed the association of the Val66Met polymorphism with serum levels of BDNF and inflammatory markers among depressed outpatients...
July 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28693408/erratum
#4
(no author information available yet)
No abstract text is available yet for this article.
July 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28610451/cognitive-function-is-largely-intact-in-methadone-maintenance-treatment-patients
#5
Odelia Elkana, Miriam Adelson, Glen M Doniger, Anat Sason, Einat Peles
OBJECTIVES: To confirm our previous findings of less cognitive impairments (based on cognitive screening tools) among methadone maintenance treatment (MMT) patients who achieved take-home dose (THD) privileges. METHODS: a random sample of 65 Israeli MMT patients were studied using computerised, age and education standardised, cognitive domains (attention, executive function, memory, motor skills), and non-computerised phonetic and semantic verbal fluency. RESULTS: Cognitive scores were within ±1 standard deviation (SD) of average for most domains, including non-verbal IQ, attention and motor skills...
July 5, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28669319/serum-inflammatory-molecules-and-markers-of-neuronal-damage-in-alcohol-dependent-subjects-after-withdrawal
#6
Murielle Girard, Dominique Malauzat, Philippe Nubukpo
OBJECTIVES: Our aim is to describe changes in serum concentration for the proinflammatory factors TNF-α, IFN-gamma, IL-1beta, IL-8, IL-6, IL-10, IL-12, and MCP-1, for the satiety factor leptin and for factors associated with neuronal changes, neuron-specific enolase (NSE) and glial activation S100-beta protein (S100-β), and explore their association with abstinence in alcohol dependent subjects after withdrawal. METHODS: Serum sampling and clinical assessments from 115 alcohol-dependent subjects admitted to a psychiatric hospital for alcohol were repeated during the first 48 hours of withdrawal (M0) and 1, 2, 4 and 6 months (M1, M2, M4, M6) after...
July 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28669318/fronto-subcortical-functional-connectivity-in-patients-with-schizophrenia-and-bipolar-disorder-during-a-verbal-fluency-task
#7
Anaïs Vandevelde, Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: Impairments in language production are common of schizophrenia (SZ) and bipolar disorder (BD). Identifying distinct functional connectivity (FC) patterns in SZ and BD may provide biomarkers for their diagnoses. METHODS: 49 participants (15 SZ, 14 BD, and 20 HC) underwent a verbal fluency task consisting of mentally generating verbs in French, alternated with periods of silence. Functional network allowed identifying activation clusters: the medio-frontal cluster (MFC), the left subcortical cluster (LSCC) and the left fronto-lateral cluster (LFLC)...
July 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28664816/cyp2c19-17-protects-against-metabolic-complications-of-clozapine-treatment
#8
Irina Piatkov, Dorgival Caetano, Yolinda Assur, Sue Lynn Lau, Micheline Coelho, Trudi Jones, Tristan Nguyen, Steven Boyages, Mark McLean
OBJECTIVES: Clozapine (CZ) is the most effective drug for managing treatment-resistant schizophrenic disorders. Its use has been limited due to adverse effects, which include weight gain and new-onset diabetes, but the incidence of these varies between patients. METHODS: We investigated 187 Clozapine Clinic patients (of whom 137 consented for genotyping) for the presence of CYP2C19*17 and its association with CZ and NCZ levels, and clinical outcomes. RESULTS: Thirty-nine percent of genotyped patients were carriers of the CYP2C 19*17 polymorphism...
June 30, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28660791/long-term-changes-of-salivary-exoglycosidases-and-their-applicability-as-chronic-alcohol-drinking-and-dependence-markers
#9
Napoleon Waszkiewicz, Ewa Maria Kratz, Sylwia Chojnowska, Anna Zalewska, Krzysztof Zwierz, Agata Szulc, Sławomir Dariusz Szajda, Anastasiya Nestsiarovich, Andrei Kapitau, Alina Kępka, Lucyna Ostrowska, Mirosława Ferens-Sieczkowska
OBJECTIVES: Investigation of long-term dynamic changes of salivary activity/output of exoglycosidases, deglycosylation processes and their applicability as alcohol markers. METHODS: Exoglycosidase (α-fucosidase (FUC), β-galactosidase (GAL), β-glucuronidase (GLU), β-hexosaminidase (HEX, HEX A and HEX B isoenzymes) and α-mannosidase (MAN)) activities were measured in the saliva of healthy social drinking controls (C), alcohol-dependent non-smokers (ANS) and alcohol-dependent smokers (AS) at the 1st, 15th, 30th and 50th day of abstinence after chronic alcohol drinking...
June 29, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28657472/evaluating-the-effects-of-exercise-on-cognitive-function-in-hypertensive-and-diabetic-patients-using-the-mental-test-and-training-system
#10
Robson Bonoto Teixeira, João Carlos Bouzas Marins, Paulo Roberto Santos Amorim, Israel Teoldo, Rocío Cupeiro, Marcelo Odilon Cabral de Andrade, Yuri de Lucas Xavier Martins, Pollyana de Rezende Castilho, Daniel Demétrio Magalhães, András Palotás, Luciana Moreira Lima
OBJECTIVES: Systemic arterial hypertension (SAH) and diabetes mellitus (DM) are important risk factors for developing cognitive impairment. General life-style changes including physical training are known to reduce elevated blood pressure and sugar levels, as well as improve mental health. The objective of this study was to evaluate whether supervised physical exercise enhances the cognitive status of patients with chronic diseases. METHODS: Volunteers with SAH, DM or SAH + DM participated in either aerobic or resistance training during a period of 12 weeks...
June 28, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28649941/treatment-effects-of-olanzapine-on-homotopic-connectivity-in-drug-free-schizophrenia-at-rest
#11
Wenbin Guo, Feng Liu, Jindong Chen, Renrong Wu, Lehua Li, Zhikun Zhang, Huafu Chen, Jingping Zhao
OBJECTIVES: Deficits in homotopic connectivity have been implicated in schizophrenia. However, alterations in homotopic connectivity associated with antipsychotic treatments in schizophrenia remain unclear due to lack of longitudinal studies. METHODS: Seventeen drug-free patients with recurrent schizophrenia and twenty-four healthy controls underwent resting-state functional magnetic resonance imaging scans. The patients were scanned at three time points (baseline, 6 weeks of treatment, and 6 months of treatment)...
June 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28649929/involvement-of-core-clock-genes-in-lithium-response
#12
Claudia Pisanu, Donatella Congiu, Carla Melis, Andrea Angius, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Alessio Squassina
No abstract text is available yet for this article.
June 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28649903/herbal-medicine-for-psychiatric-disorders-psychopharmacology-and-neuroscience-based-nomenclature
#13
Siu W Tang, Wayne Tang, Brian E Leonard
OBJECTIVES: Herbs are frequently and concurrently used with prescribed drugs by patients worldwide. While clinical trials have found some herbs to be as useful as standard psychiatric drugs, most clinicians are unaware of their pharmacological mechanisms. METHODS: We searched English language and other language literature with English abstracts listed in PubMed website, supplemented by additional through Google Scholar's free academic paper abstract website for publications on herbs, focusing on their clinical usages in mental disorders, their neurobiology and pharmacology...
June 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28532221/antiphospholipid-antibodies-are-associated-with-positive-screening-for-common-mental-disorders-in-women-with-previous-pregnancy-loss-the-noha-psy-observational-study
#14
Jean-Christophe Gris, Fabienne Cyprien, Sylvie Bouvier, Eva Cochery-Nouvellon, Géraldine Lavigne-Lissalde, Erick Mercier, Jean-Pierre Balducchi
OBJECTIVES: Case reports describe neuropsychiatric manifestations associated with antiphospholipid antibodies (aPlAbs). In patients sharing the same symptoms fulfilling the antiphospholipid syndrome (APS) clinical criteria, the prevalence of common mental disorders has, however, never been studied. METHODS: We observed women with three consecutive abortions before the 10th week of gestation or one foetal loss at or beyond the 10th week. We compared the prevalence of common psychiatric disorders detected through screening using the Mini International Neuropsychiatric Interview, 10 years after inclusion, in women with APS (n = 506), women negative for aPlAbs but carrying the F5rs6025 or F2rs1799963 thrombogenic polymorphism (n = 269), and women with negative thrombophilia screening results as controls (n = 764)...
June 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28511598/silexan-in-anxiety-disorders-clinical-data-and-pharmacological-background
#15
Siegfried Kasper, Walter E Müller, Hans-Peter Volz, Hans-Jürgen Möller, Egon Koch, Angelika Dienel
OBJECTIVES: Silexan is a lavender oil preparation available in 80-mg capsules. Here we review clinical trials investigating its anxiolytic efficacy, safety and tolerability in humans, as well as preclinical investigations supporting this therapeutic use. METHODS: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep...
June 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28532273/childhood-trauma-affects-processing-of-social-interactions-in-borderline-personality-disorder-an-event-related-potential-study-investigating-empathy-for-pain
#16
Vera Flasbeck, Björn Enzi, Martin Brüne
OBJECTIVES: Patients with borderline personality disorder (BPD) have difficulties in empathising with others and show disturbances in social interactions. Using a 'Social Interaction Empathy Task', we found that BPD patients judged neutral and psychologically painful conditions as more painful than healthy subjects. Here, we present the neural correlates underlying these differences in empathy for pain. METHODS: Female BPD patients and healthy controls completed the 'Social Interaction Empathy Task' during EEG recording...
June 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28610467/longitudinal-covariance-of-resting-state-cardiac-function-and-borderline-personality-disorder-symptoms-in-adolescent-non-suicidal-self-injury
#17
Julian Koenig, Sindy Weise, Lena Rinnewitz, Peter Parzer, Franz Resch, Michael Kaess
OBJECTIVES: Cardiac function is altered in borderline personality disorder (BPD). In adolescents with non-suicidal self-injury (NSSI) resting heart rate (HR) and vagally mediated heart rate variability (vmHRV) are associated with BPD symptoms. The study aimed to investigate longitudinal covariance of BPD symptoms and cardiac function in adolescent NSSI. METHODS: HR and vmHRV were recorded in female adolescents with NSSI (n = 17) completing a baseline and one-year follow-up assessment...
June 14, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28594264/treatment-response-and-tolerability-with-once-monthly-paliperidone-palmitate-initiated-shortly-after-hospital-admission-in-patients-with-schizophrenia
#18
Ludger Hargarter, Marjolein Lahaye, Pierre Cherubin, Martin Lambert, Marnina Swarz, Gali Joldygulov, Flavio Vischia, Veronica Chomskaya, Vasilis P Bozikas, Eva-Maria Tsapakis, Andreas Schreiner
OBJECTIVES: Partial or non-adherence in patients with schizophrenia is common and increases the risk of relapse. This study explored safety, tolerability and treatment outcomes in patients hospitalised for an exacerbation of schizophrenia initiated on maintenance treatment of once-monthly paliperidone palmitate (PP1M). METHODS: A 6-week, observational cohort study of patients initiated on PP1M within 3 weeks after hospital admission. RESULTS: Overall, 367 patients were documented, 85...
June 8, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28593819/voluntary-exercise-improves-cognitive-deficits-in-female-dominant-negative-disc1-transgenic-mouse-model-of-neuropsychiatric-disorders
#19
Hadar Segal-Gavish, Ran Barzilay, Ofri Rimoni, Daniel Offen
OBJECTIVES: Physical exercise has gained increasing interest as a treatment modality that improves prognosis in psychiatric patients. The disrupted in schizophrenia 1 (DISC1) gene is a candidate gene for major mental illness. In this study, we aimed to determine whether voluntary wheel running can improve cognitive deficits of dominant-negative DISC1 transgenic mice (DN-DISC1). METHODS: DN-DISC1 and control mice (10-week-old male and female) were placed for 14 days in a cage with or without access to a running wheel...
June 8, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28441915/early-life-adversity-induced-long-term-epigenetic-programming-associated-with-early-onset-of-chronic-physical-aggression-studies-in-humans-and-animals
#20
Dimitry A Chistiakov, Vladimir P Chekhonin
OBJECTIVES: To examine whether chronic physical aggression (CPA) in adulthood can be epigenetically programmed early in life due to exposure to early-life adversity. METHODS: Literature search of public databases such as PubMed/MEDLINE and Scopus. RESULTS: Children/adolescents susceptible for CPA and exposed to early-life abuse fail to efficiently cope with stress that in turn results in the development of CPA later in life. This phenomenon was observed in humans and animal models of aggression...
June 5, 2017: World Journal of Biological Psychiatry
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