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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/29243550/attention-deficit-hyperactivity-disorder-is-associated-with-reduced-levels-of-serum-low-density-lipoprotein-cholesterol-in-adolescents-data-from-the-population-based-german-kiggs-study
#1
Raquel Pinho, Biyao Wang, Andreas Becker, Aribert Rothenberger, Tiago F Outeiro, Christoph Herrmann-Lingen, Thomas Meyer
OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial, complex and the most common neurodevelopmental disorder in childhood. In this analysis, we tested the hypothesis that altered serum lipid patterns are associated with ADHD. METHODS: Using data from the nationwide, population-based German Health Interview and Examination Survey for Children and Adolescents (KiGGS), we compared serum levels of total cholesterol, high-density (HDL) and low-density lipoprotein (LDL) cholesterol, and also triglycerides, in participants with physician-diagnosed and/or suspected ADHD, as defined by a value of ≥7 on the hyperactivity-inattention subscale of the Strengths and Difficulties Questionnaire (SDQ), with non-ADHD controls...
December 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29243543/a-kainate-receptor-gluk4-deletion-protective-against-bipolar-disorder-is-associated-with-enhanced-cognitive-performance-across-diagnoses-in-the-twinsuk-cohort
#2
Maria Koromina, Miles Flitton, Ian Mellor, Helen Miranda Knight
OBJECTIVES: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals from the TwinsUK study. METHODS: Cognitive performance was assessed using the National Adult Reading Test, four CANTAB tests (Spatial Working Memory, Paired Associates Learning, Pattern Recognition Memory, and Reaction Time), and two Principal Component Analysis derived factors...
December 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29235890/low-density-lipoprotein-cholesterol-and-suicidal-behaviour-in-a-large-sample-of-first-episode-psychosis-patients
#3
Rosa Ayesa-Arriola, Manuel Canal Rivero, Manuel Delgado-Alvarado, Esther Setién-Suero, Jana González-Gómez, Javier Labad, Anthony S David, Benedicto Crespo-Facorro
OBJECTIVES: Our aims were to confirm the relationship between lipid and lipoprotein concentrations and suicidal behaviour in first episode psychosis (FEP) patients. METHODS: Suicidal behaviour was explored in a large FEP sample (N = 383). Baseline lipid profile was compared between those who attempted or completed suicide and those who not presented suicidal behaviour. RESULTS: Low-density lipoprotein cholesterol (LDL-c) (OR = 0.99, 95% CI= 0...
December 13, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29182037/drd4-exon-3-genotype-and-adhd-randomized-pharmacodynamic-investigation-of-treatment-response-to-methylphenidate
#4
Darya Naumova, Natalie Grizenko, Sarojini M Sengupta, Ridha Joober
OBJECTIVES: Dopamine plays an important role in modulating attention and motor behaviors, dimensions altered in attention deficit/hyperactivity disorder (ADHD). Numerous association studies have linked dopamine receptor 4 (DRD4) to increased risk of ADHD. This study investigated the effect of DRD4 exon 3 polymorphism on child behaviours in response to treatment with methylphenidate (MPH). METHODS: 374 children diagnosed with ADHD (ages 6-12) were evaluated under three experimental conditions: baseline, placebo and MPH (0...
November 28, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29172938/corrigendum
#5
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29098925/the-world-federation-of-societies-of-biological-psychiatry-wfsbp-guidelines-for-the-biological-treatment-of-bipolar-disorders-acute-and-long-term-treatment-of-mixed-states-in-bipolar-disorder
#6
Heinz Grunze, Eduard Vieta, Guy M Goodwin, Charles Bowden, Rasmus W Licht, Jean-Michel Azorin, Lakshmi Yatham, Sergey Mosolov, Hans-Jürgen Möller, Siegfried Kasper
OBJECTIVES: Although clinically highly relevant, the recognition and treatment of bipolar mixed states has played only an underpart in recent guidelines. This WFSBP guideline has been developed to supply a systematic overview of all scientific evidence pertaining to the acute and long-term treatment of bipolar mixed states in adults. METHODS: Material used for these guidelines is based on a systematic literature search using various data bases. Their scientific rigour was categorised into six levels of evidence (A-F), and different grades of recommendation to ensure practicability were assigned...
November 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29076399/cerebrospinal-fluid-and-blood-biomarkers-for-neurodegenerative-dementias-an-update-of-the-consensus-of-the-task-force-on-biological-markers-in-psychiatry-of-the-world-federation-of-societies-of-biological-psychiatry
#7
Piotr Lewczuk, Peter Riederer, Sid E O'Bryant, Marcel M Verbeek, Bruno Dubois, Pieter Jelle Visser, Kurt A Jellinger, Sebastiaan Engelborghs, Alfredo Ramirez, Lucilla Parnetti, Clifford R Jack, Charlotte E Teunissen, Harald Hampel, Alberto Lleó, Frank Jessen, Lidia Glodzik, Mony J de Leon, Anne M Fagan, José Luis Molinuevo, Willemijn J Jansen, Bengt Winblad, Leslie M Shaw, Ulf Andreasson, Markus Otto, Brit Mollenhauer, Jens Wiltfang, Martin R Turner, Inga Zerr, Ron Handels, Alexander G Thompson, Gunilla Johansson, Natalia Ermann, John Q Trojanowski, Ilker Karaca, Holger Wagner, Patrick Oeckl, Linda van Waalwijk van Doorn, Maria Bjerke, Dimitrios Kapogiannis, H Bea Kuiperij, Lucia Farotti, Yi Li, Brian A Gordon, Stéphane Epelbaum, Stephanie J B Vos, Catharina J M Klijn, William E Van Nostrand, Carolina Minguillon, Matthias Schmitz, Carla Gallo, Andrea Lopez Mato, Florence Thibaut, Simone Lista, Daniel Alcolea, Henrik Zetterberg, Kaj Blennow, Johannes Kornhuber
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised...
October 27, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29069978/assessment-of-de-novo-copy-number-variations-in-italian-patients-with-schizophrenia-detection-of-putative-mutations-involving-regulatory-enhancer-elements
#8
Giulio Piluso, Palmiero Monteleone, Silvana Galderisi, Teresa Giugliano, Alessandro Bertolino, Paola Rocca, Alessandro Rossi, Armida Mucci, Eugenio Aguglia, Ileana Andriola, Antonello Bellomo, Anna Comparelli, Francesco Gambi, Andrea Fagiolini, Carlo Marchesi, Rita Roncone, Emilio Sacchetti, Paolo Santonastaso, Alberto Siracusano, Paolo Stratta, Alfonso Tortorella, Luca Steardo, Paola Bucci, Vincenzo Nigro, Mario Maj
Objectives Variants appearing de novo in genes regulating key neurodevelopmental processes and/or in noncoding cis-regulatory elements (CREs), as enhancers, may increase the risk for schizophrenia. However, CREs involvement in schizophrenia needs to be explored more deeply. Methods We investigated de novo copy number variations (CNVs) in the whole genomic DNA obtained from 46 family trios of schizophrenia probands by using the Enhancer Chip, a customized array CGH able to investigate the whole genome with a 300Kb resolution, specific disease loci at a tenfold higher resolution, and that was highly enriched in probes in more than 1...
October 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29067888/lithium-induced-gene-expression-alterations-in-two-peripheral-cell-models-of-bipolar-disorder
#9
Sarah Kittel-Schneider, Max Hilscher, Claus-Jürgen Scholz, Heike Weber, Lena Grünewald, Ricarda Schwarz, Andreas G Chiocchetti, Andreas Reif
OBJECTIVES: The aim of our study was to investigate molecular mechanisms of lithium action by studying the gene expression profile of peripheral cell models generated from bipolar patients (BD) and healthy controls (HC). METHODS: EBV-immortalized lymphoblastoid cells (LCLs) and fibroblast cells from BD and HC were incubated with either lithiumchloride or plain medium for 3 weeks. We first conducted a microarray gene expression study. The most promising differentially regulated genes in terms of lithium-associated or disorder-associated pathways were then replicated by quantitative Real Time PCR (qRT PCR)...
October 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29057722/excessive-bodybuilding-as-pathology-a-first-neurophysiological-classification
#10
Moritz Julian Maier, Florian Benedikt Haeussinger, Martin Hautzinger, Andreas Jochen Fallgatter, Ann-Christine Ehlis
OBJECTIVES: Excessive Bodybuilding as a pathological syndrome has been classified based on two different theories: Bodybuilding as dependency or as muscle dysmorphic disorder (MDD). This study is a first attempt to find psychophysiological data supporting one of these classifications. METHODS: 24 participants (bodybuilders vs. healthy controls) were presented with pictures of bodies, exercise equipment or general reward stimuli in a control or experimental condition, and were measured with functional near-infrared spectroscopy (fNIRS)...
October 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29057711/the-effects-of-childhood-maltreatment-on-brain-structure-in-adults-with-eating-disorders
#11
Alessio Maria Monteleone, Palmiero Monteleone, Fabrizio Esposito, Anna Prinster, Valeria Ruzzi, Antonietta Canna, Marco Aiello, Francesco Di Salle, Mario Maj
OBJECTIVES: Childhood maltreatment is a non specific risk factor for eating disorders (EDs). However, no study assessed so far the impact of childhood maltreatment on brain structure of adults with EDs. Therefore, we investigated brain areas volumes and fiber tracts integrity of childhood maltreated (Mal) and non-maltreated (noMal) patients with EDs. METHODS: Thirty-six ED women and 16 healthy women underwent a MRI scanning including acquisition of a diffusion tensor imaging (DTI) sequence and a high resolution T1-weighted scan...
October 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29057702/pharmacological-treatment-of-patients-with-paraphilic-disorders-and-risk-of-sexual-offending-an-international-perspective
#12
Daniel Turner, Julius Petermann, Karen Harrison, Richard Krueger, Peer Briken
OBJECTIVES: The present study aims to evaluate existing policy and practice relating to the use of pharmacological treatments with patients suffering from paraphilic disorders who are at risk of committing further sexual offences. METHODS: A systematic literature search was conducted to document current legal policies across 26 different countries. Additionally, a questionnaire assessing the practice of pharmacological treatment was sent to practitioners involved in the treatment of patients with paraphilic disorders...
October 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29022753/lower-heart-rate-variability-at-baseline-is-associated-with-more-consecutive-intrusive-memories-in-an-experimental-distressing-film-paradigm
#13
Felicitas Rombold-Bruehl, Christian Otte, Babette Renneberg, Anna Schmied, Frank Zimmermann-Viehoff, Katja Wingenfeld, Stefan Roepke
OBJECTIVES: First evidence suggests that lower heart rate variability (HRV) is associated with more cognitive control deficits, a risk factor for the development of intrusive memories. The aim of this study was to determine whether high-frequency (HF) and low-frequency/high-frequency (LF/HF) ratio components of HRV at rest before an intrusion-inducing stressor would predict consecutive intrusive memories. METHODS: Healthy female participants (n = 60) watched an established distressing film which induced intrusions...
October 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28984491/monitoring-for-antidepressant-associated-adverse-events-in-the-treatment-of-patients-with-major-depressive-disorder-an-international-consensus-statement
#14
Seetal Dodd, Philip B Mitchell, Michael Bauer, Lakshmi Yatham, Allan H Young, Sidney H Kennedy, Lana Williams, Trisha Suppes, Carlos Lopez Jaramillo, Madhukar H Trivedi, Maurizio Fava, A John Rush, Roger S McIntyre, Michael E Thase, Raymond W Lam, Emanuel Severus, Siegfried Kasper, Michael Berk
OBJECTIVES: These recommendations were designed to ensure safety for patients with major depressive disorder (MDD) and to aid monitoring and management of adverse effects during treatment with approved antidepressant medications. The recommendations aim to inform prescribers about both the risks associated with these treatments and approaches for mitigating such risks. METHODS: Expert contributors were sought internationally by contacting representatives of key stakeholder professional societies in the treatment of MDD (ASBDD, CANMAT, WFSBP and ISAD)...
October 6, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28797215/the-cadm2-gene-is-associated-with-processing-speed-performance-evidence-among-elderly-with-type-2-diabetes
#15
Lior Greenbaum, Ramit Ravona-Springer, Abigail Livny, Shahar Shelly, Inbal Sharvit-Ginon, Ithamar Ganmore, Anna Alkelai, Anthony Heymann, Michal Schnaider Beeri
OBJECTIVES: Recent large-scale meta-analysis of genome-wide association studies (GWAS) from multiple cohorts, demonstrated the association of the single nucleotide polymorphism (SNP) rs17518584, with processing speed (measured by the Digit Symbol Substitution Test (DSST) or the Letter Digit Substitution Test (LDST)), at GWAS significance level. This SNP is located within the cell adhesion molecule 2 (CADM2) gene. We aimed to validate this finding in our sample of 944 cognitively normal Jewish elderly individuals with type 2 diabetes (T2D), a population which is at risk for cognitive decline and dementia...
October 5, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28971736/genetic-analysis-for-cognitive-flexibility-in-trail-making-test-in-attention-deficit-hyperactivity-disorder-patients-from-snp-gene-to-pathway
#16
Kunlin Zhang, Zili Fan, Yufeng Wang, Stephen V Faraone, Li Yang, Suhua Chang
OBJECTIVES: Investigation of the genetic basis of endophenotype and analysis the pathways with multiple genes of small effects might increase the understanding of the genetic basis of attention deficit hyperactivity disorder (ADHD). Here we aimed to explore the genetic basis of cognitive flexibility in ADHD at SNP, gene and pathway level. METHODS: The Trail-Making Test (TMT) was used to test the cognitive flexibility of 788 ADHD patients. A genome-wide association analysis of cognitive flexibility was conducted for 644,166 single nucleotide polymorphisms (SNPs)...
October 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28971725/transcranial-sonography-in-psychiatry-as-a-potential-tool-in-diagnosis-and-research
#17
Carsten Drepper, Julia Geißler, Giuseppe Pastura, Rezzak Yilmaz, Daniela Berg, Marcel Romanos, Manfred Gerlach
Objectives During the last two decades' transcranial sonography (TCS) of the brain parenchyma evolved from a pure research tool to a clinical relevant neuroimaging method especially in Parkinson's disease and related movement disorders. The aim of this systematic review is to update and summarize the published TCS findings in psychiatric disorders and critically address the question whether TCS may be a valuable tool for the diagnosis or differential diagnosis of psychiatric disorders similarly to the field of movement disorders...
October 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28854834/drd2-and-ankk1-genes-associate-with-late-onset-heroin-dependence-in-men
#18
Chang-Chih Tsou, Han-Wei Chou, Pei-Shen Ho, Shin-Chang Kuo, Chun-Yen Chen, Chang-Chih Huang, Chih-Sung Liang, Ru-Band Lu, San-Yuan Huang
OBJECTIVES: Dopamine plays an important role in reward system of heroin dependence (HD), and dopaminergic D2 receptor (DRD2) gene is a candidate for the aetiology of HD. Ankyrin repeat and kinase domain containing 1 (ANKK1) gene is proximal to DRD2 and may influence its expression. We explored whether DRD2 and ANKK1 associate with occurrence of HD, and whether the genetic variants influence personality traits in male patients with HD. METHODS: DRD2/ANKK1 polymorphisms were analysed in 950 unrelated Han Chinese male participants (601 HD patients and 349 healthy controls)...
September 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28854847/rna-sequencing-of-bipolar-disorder-lymphoblastoid-cell-lines-implicates-the-neurotrophic-factor-hrp-3-in-lithium-s-clinical-efficacy
#19
Elena Milanesi, Irena Voinsky, Adva Hadar, Ala Srouji, Carlo Maj, Tatyana Shekhtman, Michael Gershovits, Shlomit Gilad, Caterina Chillotti, Alessio Squassina, James B Potash, Thomas G Schulze, Fernando S Goes, Peter Zandi, John R Kelsoe, David Gurwitz
OBJECTIVES: Lithium remains the oldest and most effective treatment for mood stabilisation in bipolar disorder (BD), even though at least half of patients are only partially responsive or do not respond. This study aimed to identify biomarkers associated with lithium response in BD, based on comparing RNA sequencing information derived from lymphoblastoid cell lines (LCLs) of lithium-responsive (LR) versus lithium non-responsive (LNR) BD patients, to assess gene expression variations that might bear on treatment outcome...
September 22, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28922980/a-genome-wide-association-study-of-early-gamma-band-response-in-a-schizophrenia-case-control-sample
#20
Bettina Konte, Gregor Leicht, Ina Giegling, Oliver Pogarell, Susanne Karch, Annette M Hartmann, Marion Friedl, Ulrich Hegerl, Dan Rujescu, Christoph Mulert
OBJECTIVES: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity. METHODS: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315). RESULTS: No marker surpassed the threshold for genome-wide significant association...
September 19, 2017: World Journal of Biological Psychiatry
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