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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/29683396/reduced-peripheral-availability-of-tryptophan-and-increased-activation-of-the-kynurenine-pathway-and-cortisol-correlate-with-major-depression-and-suicide
#1
Amel Messaoud, Mensi Rym, Wahiba Douki, Fadoua Neffati, Mohamed Fadhel Najjar, Gabriella Gobbi, Flavia Valtorta, Lotfi Gaha, Stefano Comai
OBJECTIVES: Patients affected by major depression (MDD) are at high risk of suicide. The metabolism of tryptophan (Trp) along the serotonin (5-HT) and kynurenine (Kyn) pathways was found dysfunctional in MDD and in suicide. However, a clear biological framework linking dysfunctions in Trp metabolism via 5-HT and Kyn, cortisol, and the activities of tryptophan and indoleamino 2,3-dioxygenase (TDO, IDO) enzymes has not been yet clarified in MDD with or without suicidal behaviors. METHODS: We analyzed peripheral markers of Trp via 5-HT and Kyn pathways, Kyn/Trp ratio as a measure of TDO/IDO activities, cortisol, and psychopathology in 73 non-suicidal and 56 suicidal MDD patients, and in 40 healthy controls...
April 23, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29611450/elevated-serum-vascular-endothelial-growth-factor-in-treatment-resistant-schizophrenia-treated-with-electroconvulsive-therapy-positive-association-with-therapeutic-effects
#2
Wenhuan Xiao, Qiongqiong Zhan, Fei Ye, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
OBJECTIVES: As the name implies, vascular endothelial growth factor (VEGF) enhances angiogenesis, promotes vascular permeability, and stimulates neurogenesis in the adult brain. Furthermore, animal model studies have shown that electroconvulsive therapy (ECT), which is primarily utilized in cases of treatment-resistant schizophrenia (TRS), regulates the expression of VEGF. The current study focuses largely on the effect of ECT on VEGF serum concentration, and the relationship between VEGF and therapeutic effects in patients diagnosed with TRS...
April 3, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29521179/familial-abnormalities-of-endocannabinoid-signaling-in-schizophrenia
#3
Dagmar Koethe, Franziska Pahlisch, Martin Hellmich, Cathrin Rohleder, Juliane K Mueller, Andreas Meyer-Lindenberg, E Fuller Torrey, Daniele Piomelli, F Markus Leweke
OBJECTIVES: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states. METHODS: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from 25 twin pairs discordant for schizophrenia, six discordant for bipolar disorder and eight healthy twin pairs to determine hereditary traits...
March 22, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29425059/prader-willi-syndrome-and-angelman-syndrome-visualisation-of-the-molecular-pathways-for-two-chromosomal-disorders
#4
Friederike Ehrhart, Kelly J M Janssen, Susan L Coort, Chris T Evelo, Leopold M G Curfs
OBJECTIVES: Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are two syndromes that are caused by the same chromosomal deletion on 15q11.2-q13. Due to methylation patterns, different genes are responsible for the two distinct phenotypes resulting in the disorders. Patients of both disorders exhibit hypotonia in neonatal stage, delay in development and hypopigmentation. Typical features for PWS include hyperphagia, which leads to obesity, the major cause of mortality, and hypogonadism...
March 1, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29376460/anxiety-disorders-and-crp-in-a-population-cohort-study-with-54-326-participants-the-lifelines-study
#5
Petrus J W Naudé, Annelieke M Roest, Dan J Stein, Peter de Jonge, Bennard Doornbos
OBJECTIVES: Growing evidence indicates that inflammatory processes may play a role in the pathogenesis of anxiety disorders. Nevertheless, much remains to be learned about the involvement of inflammation, including C-reactive protein (CRP), in specific anxiety disorders. This study examines the relation between anxiety disorders and CRP. METHODS: Associations of serum CRP with anxiety disorders were determined in a large population study (n = 54,326 participants, mean age = 47 years; 59% female), the LifeLines cohort...
February 22, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29380665/repeated-cocaine-exposure-dysregulates-bdnf-expression-and-signaling-in-the-mesocorticolimbic-pathway-of-the-adolescent-rat
#6
Lucia Caffino, Giuseppe Giannotti, Giulia Messa, Francesca Mottarlini, Fabio Fumagalli
OBJECTIVES: Long-term abstinence following cocaine exposure up-regulates brain-derived neurotrophic factor (BDNF) expression in the mesocorticolimbic pathway. Given the increased vulnerability to drug abuse typical of adolescence, we hypothesized that changes in BDNF expression may become manifest early after the end of cocaine treatment in the adolescent brain. METHODS: Rats received cocaine injections from postnatal day 28 (PND28) to PND42 and the mesocorticolimbic expression of BDNF was measured by real-time PCR and Western blotting at PND43...
February 21, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29376462/salivary-cortisol-as-predictor-for-depression-characteristics-and-remission-in-electroconvulsive-therapy-in-older-persons
#7
Danii L S Suijk, Annemieke Dols, Eric van Exel, Max L Stek, Eveline Veltman, Filip Bouckaert, Pascal Sienaert, Didi Rhebergen
OBJECTIVES: Electroconvulsive therapy (ECT) is the most effective treatment for depression; however, consensus on predictors for ECT outcome is lacking. We aim to examine the relation between pre-ECT salivary cortisol values and clinical characteristics and ECT outcome in depressed, older persons. METHODS: A total of 102 inpatients meeting DSM-IV criteria for depression and referred for ECT were selected. Salivary cortisol was assessed at five time points during the day, providing insight into the cortisol awakening curve to the ground (AUCg) and to the increase (AUCi) and evening cortisol level...
February 21, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29364039/neurophysiological-correlate-of-emotional-regulation-in-cognitive-and-motor-deficits-in-tourette-s-syndrome
#8
Navkiran Kalsi, Renata Tambelli, Daniela Altavilla, Cristina Trentini, Sara Panunzi, Mariella Stanca, Paola Aceto, Francesco Cardona, Carlo Lai
OBJECTIVES: The present study investigated the role of different emotions in the expression of cognitive and motor control abilities of children having Tourette's syndrome (TS) compared to healthy controls. METHODS: The electroencephalography activity of 33 children (mean age in final sample: TS (n = 10) = 10.5 ± 2.3; control (n = 10) = 10.1 ± 2.9) was recorded during a visual task consisting of four emotional face cues (anger, happiness, neutral and sadness) followed by a target in congruent or incongruent position with emotional cue...
February 21, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29457916/systematic-review-of-psychiatric-signs-in-niemann-pick-disease-type-c
#9
Olivier Bonnot, Hans-Hermann Klünemann, Christian Velten, Juan Vicente Torres Martin, Mark Walterfang
OBJECTIVES: We conducted the first systematic literature review and analysis of psychiatric manifestations in Niemann-Pick disease type C (NPC) to describe: 1) time of occurrence of psychiatric manifestations relative to other disease manifestations; 2) frequent combinations of psychiatric, neurological and visceral disease manifestations. METHODS: A systematic EMBase literature search was conducted to identify, collate and analyze published data from patients with NPC associated with psychiatric symptoms, published between January 1967 and November 2015...
February 19, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29457912/decreased-resting-gamma-activity-in-adult-attention-deficit-hyperactivity-disorder
#10
László Tombor, Brigitta Kakuszi, Szilvia Papp, János Réthelyi, István Bitter, Pál Czobor
OBJECTIVES: To delineate task-free gamma activity in adult ADHD and healthy control subjects based on high-density EEG recordings. Relationship of gamma activity with symptom severity was also examined, since gamma activity is considered as an index of network functions in the brain that underlie higher-order cognitive processes. METHODS: Spontaneous-EEG was recorded in adult ADHD subjects (N = 42;25 methylphenidate-naïve and 17 on methylphenidate treatment) and controls (N = 59) with eyes open...
February 19, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29353531/oxytocin-receptor-gene-variation-behavioural-inhibition-and-adult-separation-anxiety-role-in-complicated-grief
#11
Miriam A Schiele, Barbara Costa, Marianna Abelli, Claudia Martini, David S Baldwin, Katharina Domschke, Stefano Pini
OBJECTIVES: Complicated grief (CG) following bereavement significantly increases the risk for mood and anxiety disorders. The severity of grief reactions may be interactively influenced by temperamental and psychological factors such as behavioural inhibition (BI) and separation anxiety (SA) as well as biological factors. Given its central role in attachment and stress processing, a genetic variant in the oxytocin receptor (OXTR) gene was thus investigated in order to elucidate the direction of association as well as its interaction with BI and SA in the moderation of CG severity...
February 5, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29338494/neural-correlates-of-response-inhibition-in-patients-with-bipolar-disorder-during-acute-versus-remitted-phase
#12
Juliane Kopf, Stefan Glöckner, Martin Schecklmann, Thomas Dresler, Michael M Plichta, Julia Veeh, Sarah Kittel-Schneider, Andreas Reif
OBJECTIVES: Elevated behavioural impulsivity has been shown to be a core feature of bipolar disorder. However, no study has so far investigated impulsivity-related brain activation in patients with BD during acute versus remitted phase. To address the question whether elevated behavioural impulsivity and its differential neural pathways is a state or trait marker of BD, we employed a combined stop signal-go/no-go task in 30 controls, and 37 depressed and 15 remitted patients who were retested...
February 5, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29334322/plasma-brain-derived-neurotrophic-factor-pbdnf-and-executive-dysfunctions-in-patients-with-major-depressive-disorder
#13
Stefanie Wagner, Sarah Kayser, Jan Engelmann, Konrad F Schlicht, Nadine Dreimüller, Oliver Tüscher, Florian Müller-Dahlhaus, Dieter F Braus, André Tadić, Alexandra Neyazi, Helge Frieling, Klaus Lieb
OBJECTIVES: Executive dysfunctions are frequently seen in patients with major depressive disorder (MDD) and normalise in many cases during effective antidepressant therapy. This study investigated whether a normalisation of executive dysfunctions during antidepressant treatment correlates with or can be predicted by clinical parameters or levels of brain-derived neurotrophic factor (BDNF). METHODS: In 110 MDD patients with executive dysfunctions (percentile <16), executive functions and plasma BDNF levels were analysed at baseline, and days 14 and 56 of an antidepressant treatment...
February 2, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29383983/the-role-of-the-gut-microbiota-in-schizophrenia-current-and-future-perspectives
#14
Daniela Rodrigues-Amorim, Tania Rivera-Baltanás, Benito Regueiro, Carlos Spuch, María Elena de Las Heras, Raul Váquez-Noguerol Méndez, Maria Nieto-Araujo, C Barreiro-Villar, Jose M Olivares, Roberto C Agís-Balboa
OBJECTIVES: Schizophrenia is a poorly understood chronic disease. Its pathophysiology is complex, dynamic, and linked to epigenetic mechanisms and microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing, to its multidimensional implications: temporal and spatial variability. Microbiota involvement and epigenetic mechanisms are factors that are currently being considered to better understand another dimension of schizophrenia. METHODS: This review summarizes and discusses currently available information, focusing on the microbiota, epigenetic mechanisms, technological approaches aimed at performing exhaustive analyses of the microbiota, and psychotherapies, to establish future perspectives...
January 31, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29688142/editorial
#15
Siegfried Kasper
No abstract text is available yet for this article.
June 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29513115/editorial
#16
Siegfried Kasper
No abstract text is available yet for this article.
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29493375/tdm-in-psychiatry-and-neurology-a-comprehensive-summary-of-the-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology-update-2017-a-tool-for-clinicians
#17
Georgios Schoretsanitis, Michael Paulzen, Stefan Unterecker, Markus Schwarz, Andreas Conca, Gerald Zernig, Gerhard Gründer, Ekkerhard Haen, Pierre Baumann, Niels Bergemann, Hans Willi Clement, Katharina Domschke, Gabriel Eckermann, Karin Egberts, Manfred Gerlach, Christine Greiner, Ursula Havemann-Reinecke, Gudrun Hefner, Renate Helmer, Ger Janssen, Eveline Jaquenoud-Sirot, Gerd Laux, Thomas Messer, Rainald Mössner, Matthias J Müller, Bruno Pfuhlmann, Peter Riederer, Alois Saria, Bernd Schoppek, Margarete Silva Gracia, Benedikt Stegmann, Werner Steimer, Julia C Stingl, Manfred Uhr, Sven Ulrich, Roland Waschgler, Gabriela Zurek, Christoph Hiemke
OBJECTIVES: Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations in blood, pharmacological interpretation and treatment guidance. TDM introduces a precision medicine tool in times of increasing awareness of the need for personalized treatment. In neurology and psychiatry, TDM can guide pharmacotherapy for patient subgroups such as children, adolescents, pregnant women, elderly patients, patients with intellectual disabilities, patients with substance use disorders, individuals with pharmacokinetic peculiarities and forensic patients...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29388889/editorial
#18
Siegfried Kasper
No abstract text is available yet for this article.
March 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29345544/editorial
#19
Siegfried Kasper
No abstract text is available yet for this article.
February 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29251065/the-potential-influence-of-led-lighting-on-mental-illness
#20
Michael Bauer, Tasha Glenn, Scott Monteith, John F Gottlieb, Philipp S Ritter, John Geddes, Peter C Whybrow
OBJECTIVES: Two recent scientific breakthroughs may alter the treatment of mental illness, as discussed in this narrative review. The first was the invention of white light-emitting diodes (LEDs), which enabled an ongoing, rapid transition to energy-efficient LEDs for lighting, and the use of LEDs to backlight digital devices. The second was the discovery of melanopsin-expressing photosensitive retinal ganglion cells, which detect environmental irradiance and mediate non-image forming (NIF) functions including circadian entrainment, melatonin secretion, alertness, sleep regulation and the pupillary light reflex...
February 2018: World Journal of Biological Psychiatry
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