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World Journal of Biological Psychiatry

Dario Cattaneo, Sara Baldelli, Chiara Resnati, Andrea Giacomelli, Paola Meraviglia, Davide Minisci, Noemi Astuti, Annalisa Ridolfo, Giuseppe V De Socio, Emilio Clementi, Massimo Galli, Cristina Gervasoni
OBJECTIVES: The management of psychiatric illness in HIV-infected patients is clinically challenging because of the risk of potential drug-drug interactions. Here, we aimed to measure the antidepressant and/or antipsychotic drug concentrations in HIV-infected patients during routine outpatient visits. METHODS: Six hundred HIV-infected patients were screened during the first 15 months after the introduction of our outpatient polytherapy management service in a search for subjects treated with psychotropic drugs for at least three months...
July 30, 2018: World Journal of Biological Psychiatry
Alessandra Mallei, Alessandro Ieraci, Maurizio Popoli
OBJECTIVES: Although stress is considered a primary risk factor for neuropsychiatric disorders, a majority of individuals are resilient to the effects of stress exposure and successfully adapts to adverse life events, while others, the so-called susceptible individuals, may have problems to properly adapt to environmental changes. However, the mechanisms underlying these different responses to stress exposure are poorly understood. METHODS: Adult male C57BL/6J mice were exposed to chronic social defeat stress protocol and levels of Brain Derived Neurotrophic Factor (BDNF) transcripts and epigenetic modifying enzymes were analysed by real-time PCR in the hippocampus (HPC) and prefrontal cortex (PFC) of susceptible and resilient mice...
July 30, 2018: World Journal of Biological Psychiatry
Lindsay Melhuish Beaupre, Gregory M Brown, James L Kennedy
BACKGROUND: A core symptom of major depressive disorder (MDD), is sleep disturbance, specifically hypersomnia or insomnia. Sleep is highly regulated by circadian rhythms, controlled by circadian genes, that act through a series of feedback loops to regulate the sleep-wake cycle. OBJECTIVES: To the best of our knowledge, a systematic review regarding the core circadian genes and their role in MDD has not been published recently. More specifically, a review of these genes and their role in sleep disturbances in depressed individuals appears to have never been done...
July 30, 2018: World Journal of Biological Psychiatry
Katrin Druschky, Stefan Bleich, Renate Grohmann, Rolf R Engel, Alexandra Neyazi, Susanne Stübner, Sermin Toto
OBJECTIVES: The study aimed to assess seizure rates related to different antipsychotic drugs (APDs) in a clinical setting by using data from the drug safety program Arzneimittelsicherheit in der Psychiatrie (AMSP) Methods: Psychotropic drug utilization data and reports of APD-related seizures were collected in 89 psychiatric hospitals in Austria, Germany and Switzerland from the time period of 1993-2015. RESULTS: Out of 475,096 patients under surveillance, 320,383 patients were treated with APDs for the main indications of schizophrenic disorders, mood disorders and organic disorders...
July 30, 2018: World Journal of Biological Psychiatry
Johnathan Pierson, Rajashekar Reddy Yeruva, Rif S El-Mallakh
OBJECTIVES: Schizophrenia is a severe psychiatric illness that has been purported to be causally related to in utero infection of neurotropic organisms. For obvious ethical reasons, this hypothesis has never been tested prospectively in humans. However, with the recent introduction of Zika virus into the New World offers the opportunity to test the hypothesis infection hypothesis of schizophrenia. METHODS: This is a directed review examining the hypothesis. The literature relevant to Zika virus transmission in the New World, its biology, and neurotropy is reviewed...
July 27, 2018: World Journal of Biological Psychiatry
Martina Platzer, Frederike T Fellendorf, Susanne A Bengesser, Armin Birner, Nina Dalkner, Carlo Hamm, Riccarda Hartleb, Robert Queissner, René Pilz, Alexandra Rieger, Alexander Maget, Harald Mangge, Sieglinde Zelzer, Bernd Reininghaus, Hans-Peter Kapfhammer, Eva Z Reininghaus
OBJECTIVES: Bipolar disorder (BD) is often accompanied by medical comorbidities, which affect illness course and prognosis. Adipokines may not only be involved in the aetiopathogenetic mechanisms of these comorbidities; there might be an association between adipokines and the neuropsychiatric core features of BD such as mood disturbances and cognitive deficits. METHODS: In this investigation, fasting blood samples from 120 individuals with BD (75 euthymic and 45 with mild depressive symptoms) and 68 control subjects were taken and adiponectin and leptin concentrations were analysed...
July 26, 2018: World Journal of Biological Psychiatry
Jeverson Moreira, Gaëlle Noé, Savithri Rangarajan, Cindie Courtin, Bruno Etain, Pierre A Geoffroy, Jean-Louis Laplanche, Michel Vidal, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: Lithium is the leading mood stabiliser for maintenance treatment in bipolar disorder (BD). However, response to lithium is heterogeneous with more than 60% of patients experiencing partial or no response. In vitro and in vivo molecular studies have reported the implication of kinases in the pathophysiology of BD. METHODS: Since kinases are putative targets for lithium therapeutic action, we conducted the first pilot study using kinase array technology to evaluate the global serine/threonine kinases (STK) profiles in cell lines from BD I subtype patients classified as lithium excellent-responders (ER) and non-responder (NR) to lithium treatment...
July 23, 2018: World Journal of Biological Psychiatry
Srisaiyini Kidnapillai, Chiara C Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia M Dean, Tamsyn Crowley, Stéphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk, Ken Walder
OBJECTIVES: To create a gene expression signature (GES) to represent the biological effects of a combination of known drugs for bipolar disorder (BD) on cultured human neuronal cells (NT2-N) and rat brains, which also has evidence of differential expression in individuals with BD. To use the GES to identify new drugs for BD using Connectivity Map (CMap). METHODS: NT2-N (n = 20) cells and rats (n = 8) were treated with a BD drug combination (lithium, valproate, quetiapine and lamotrigine) or vehicle for 24 and 6 hours, respectively...
June 29, 2018: World Journal of Biological Psychiatry
Ulrike Heitz, Martina Papmeyer, Erich Studerus, Laura Egloff, Sarah Ittig, Christina Andreou, Tobias Vogel, Stefan Borgwardt, Marc Graf, Anne Eckert, Anita Riecher-Rössler
OBJECTIVES: Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive processes. Since cognitive deficits are a core feature of psychotic disorders, the investigation of BDNF levels in psychosis and their correlation with cognition has received increased attention. However, there are no studies investigating BDNF levels in individuals with an at-risk mental state (ARMS) for psychosis. Hence, the aims of the present study were: (1) assessing peripheral BDNF levels across different (potential) stages of psychosis; (2) investigating their association with cognition...
June 25, 2018: World Journal of Biological Psychiatry
Nick Kates, Bruce Arroll, Elizabeth Currie, Charlotte Hanlon, Linda Gask, Henrikje Klasen, Graham Meadows, Godfrey Rukundo, Nadiya Sunderji, Torleif Ruud, Mark Williams
OBJECTIVE: Previous guidelines and planning documents have identified the key role primary care providers play in delivering mental health care, including the recommendation from the WHO that meeting the mental health needs of the population in many low and middle income countries will only be achieved through greater integration of mental health services within general medical settings. This position paper aims to build upon this work and present a global framework for enhancing mental health care delivered within primary care...
June 20, 2018: World Journal of Biological Psychiatry
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
Natascia Brondino, Matteo Rocchetti, Laura Fusar-Poli, Stefano Damiani, Arianna Goggi, Giuseppe Chiodelli, Serafino Corti, Livia Visai, Pierluigi Politi
OBJECTIVES: Ciliary neurotrophic factor (CNTF) is a neurotrophin which could signal neuronal suffering and at the same time acts as a neuroprotective agent. In the present study we aimed to evaluate CNTF serum levels in Autism Spectrum Disorders (ASD). In fact, considering the role of CNTF as a neuronal damage signal and the role of neuroinflammation, excito-inhibitory imbalance and excitotoxicity in the pathogenesis of ASD, a possible alteration of CNTF in ASD could be hypothesised. METHODS: We recruited 23 individuals with ASD and intellectual disability (ID), 20 ID subjects and 26 typical adults...
June 5, 2018: World Journal of Biological Psychiatry
Rachel D Freed, Lushna M Mehra, Daniel Laor, Manishkumar Patel, Carmen M Alonso, Seunghee Kim-Schulze, Vilma Gabbay
Objectives Peripheral inflammation has been associated with multiple psychiatric disorders, particularly with depression. However, findings remain inconsistent and unreproducible, most likely due to the disorder's heterogeneity in phenotypic presentation. Therefore, in the present study, in an effort to account for inter-individual differences in symptom severity, we utilised a dimensional approach to assess the relationships between a broad panel of inflammatory cytokines and key psychiatric symptoms (i.e...
May 30, 2018: World Journal of Biological Psychiatry
Amel Messaoud, Rym Mensi, Wahiba Douki, Fadoua Neffati, Mohamed Fadhel Najjar, Gabriella Gobbi, Flavia Valtorta, Lotfi Gaha, Stefano Comai
OBJECTIVES: Patients affected by major depression (MDD) are at high risk of suicide. The metabolism of tryptophan (Trp) along the serotonin (5-HT) and kynurenine (Kyn) pathways was found dysfunctional in MDD and in suicide. However, a clear biological framework linking dysfunctions in Trp metabolism via 5-HT and Kyn, cortisol, and the activities of tryptophan and indoleamino 2,3-dioxygenase (TDO, IDO) enzymes has not been yet clarified in MDD with or without suicidal behaviours. METHODS: We analysed peripheral markers of Trp via 5-HT and Kyn pathways, Kyn/Trp ratio as a measure of TDO/IDO activities, cortisol, and psychopathology in 73 non-suicidal and 56 suicidal MDD patients, and in 40 healthy controls...
May 23, 2018: World Journal of Biological Psychiatry
Siegfried Kasper
No abstract text is available yet for this article.
August 2018: World Journal of Biological Psychiatry
(no author information available yet)
No abstract text is available yet for this article.
August 2018: World Journal of Biological Psychiatry
Seetal Dodd, Philip B Mitchell, Michael Bauer, Lakshmi Yatham, Allan H Young, Sidney H Kennedy, Lana Williams, Trisha Suppes, Carlos Lopez Jaramillo, Madhukar H Trivedi, Maurizio Fava, A John Rush, Roger S McIntyre, Michael E Thase, Raymond W Lam, Emanuel Severus, Siegfried Kasper, Michael Berk
OBJECTIVES: These recommendations were designed to ensure safety for patients with major depressive disorder (MDD) and to aid monitoring and management of adverse effects during treatment with approved antidepressant medications. The recommendations aim to inform prescribers about both the risks associated with these treatments and approaches for mitigating such risks. METHODS: Expert contributors were sought internationally by contacting representatives of key stakeholder professional societies in the treatment of MDD (ASBDD, CANMAT, WFSBP and ISAD)...
August 2018: World Journal of Biological Psychiatry
Laura Kranaster, Carolin Hoyer, Suna S Aksay, Jan Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
August 2018: World Journal of Biological Psychiatry
Marco Antonio Caldieraro, Madison McKee, Sandra Leistner-Segal, Edgar Arrua Vares, Francyne Kubaski, Lucas Spanemberg, Ana Carolina Brusius-Facchin, Marcelo P Fleck, David Mischoulon
OBJECTIVES: Current evidence supports participation of neurotrophic and inflammatory factors in the pathogenesis of major depressive disorder (MDD). Some studies reported an association between the Val66Met polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene with MDD and peripheral BDNF levels. However, no previous studies have examined the association of this polymorphism with inflammation. The present study assessed the association of the Val66Met polymorphism with serum levels of BDNF and inflammatory markers among depressed outpatients...
August 2018: World Journal of Biological Psychiatry
Andrea Carlo Rossetti, Maria Serena Paladini, Giorgio Racagni, Marco Andrea Riva, Annamaria Cattaneo, Raffaella Molteni
OBJECTIVES: Several studies reported that antidepressant drugs have immune-regulatory effects by acting on specific inflammatory mediators. However, considering the highly complex nature of the inflammatory response, we have adopted an unbiased genome-wide strategy to investigate the immune-regulatory activity of the antidepressant agomelatine in modulating the response to an acute inflammatory challenge. METHODS: Microarray analysis was used to identify genes modulated in the ventral hippocampus of adult rats chronically treated with agomelatine (40 mg/kg, os) before being challenged with a single injection of lipopolysaccharide (LPS; 250 μg/kg, i...
August 2018: World Journal of Biological Psychiatry
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