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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/27762161/structural-brain-changes-in-first-episode-mania-with-and-without-psychosis-data-from-the-systematic-treatment-optimization-program-for-early-mania-stop-em
#1
Kamyar Keramatian, Taj Dhanoa, Alexander McGirr, Donna J Lang, William G Honer, Raymond W Lam, Lakshmi N Yatham
OBJECTIVES: The neurobiological underpinnings of bipolar I disorder are not yet understood. Previous structural neuroimaging studies of bipolar disorder have produced rather conflicting results. We hypothesise that clinical sub-phenotypes of bipolar I disorder defined by their psychotic symptoms, especially those with mood-incongruent psychotic features, may have more extensive structural brain abnormalities. METHODS: We investigated structural brain alterations in patients with first-episode mania (n = 55) with mood-congruent (n = 16) and mood-incongruent (n = 32) psychotic features, as well as those without psychotic symptoms (n = 7), relative to healthy subjects (n = 56)...
December 8, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27905213/hepatic-lipid-and-genetic-factors-associated-with-obesity-crosstalk-with-alcohol-dependence
#2
Kimberly Goodyear, Mary R Lee, Melanie L Schwandt, Colin A Hodgkinson, Lorenzo Leggio
OBJECTIVES: Alcohol dependence represents a leading cause of mortality and morbidity. Understanding the variables that contribute to this diagnosis and its severity is critical. An overlap between factors that may predispose people to become obese and those that may increase the risk of alcohol dependence may exist. However, data in the literature are not conclusive. Therefore, this study aimed to identify the association between alcohol dependence and obesity-related factors, including biochemical and genetic factors...
December 1, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27892759/the-use-of-ketamine-in-ect-anaesthesia-a-systematic-review-and-critical-commentary-on-efficacy-cognitive-safety-and-seizure-outcomes
#3
Verònica Gálvez, Lucy McGuirk, Colleen K Loo
OBJECTIVES: This review will discuss ECT efficacy and cognitive outcomes when using ketamine as an ECT anaesthetic compared to other anaesthetics, taking into account important moderator variables that have often not been considered to date. It will also include information on safety and other ECT outcomes (seizure threshold and quality). METHODS: A systematic search through MEDLINE, PubMed, PsychINFO, Cochrane Databases and reference lists from retrieved articles was performed...
November 28, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27885918/increased-deficits-in-emotion-recognition-and-regulation-in-children-and-adolescents-with-exogenous-obesity
#4
Ipek Percinel, Burcu Ozbaran, Sezen Kose, Damla Goksen Simsek, Sukran Darcan
OBJECTIVES: In this study we aimed to evaluate emotion recognition and emotion regulation skills of children with exogenous obesity between ages of 11 and 18 years and compare them with healthy controls. METHODS: Schedule for Affective Disorders and Schizophrenia for School Aged Children, were used for psychiatric evaluations. Emotion recognition skills were evaluated using Faces Test and Reading the Mind in the Eyes Test. Difficulties in Emotions Regulation Scale was used for evaluating skills of emotion regulation...
November 25, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27873550/self-and-other-body-perception-in-anorexia-nervosa-the-role-of-posterior-dmn-nodes
#5
Esther Via, Ximena Goldberg, Isabel Sánchez, Laura Forcano, Ben J Harrison, Christopher G Davey, Jesús Pujol, Ignacio Martínez-Zalacaín, Fernando Fernández-Aranda, Carles Soriano-Mas, Narcís Cardoner, José M Menchón
OBJECTIVES: Body image distortion is a core symptom of anorexia nervosa (AN), which involves alterations in self- (and other's) evaluative processes arising during body perception. At a neural level, self-related information is thought to rely on areas of the so-called default mode network (DMN), which, additionally, shows prominent synchronised activity at rest. METHODS: Twenty female patients with AN and 20 matched healthy controls were scanned using magnetic resonance imaging when: (a) viewing video clips of their own body and another's body; (b) at rest...
November 22, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27784192/the-schizophrenia-susceptibility-gene-znf804a-confers-risk-of-major-mood-disorders
#6
Jianjun Ou, Ming Li, Xiao Xiao
OBJECTIVES: Genome-wide association studies (GWAS) followed by independent replications suggest that ZNF804A is a risk gene for schizophrenia (SCZ), considering the substantial genetic overlap between SCZ and major mood disorders (e.g., bipolar disorder (BPD) and major depressive disorder (MDD)). METHODS: We collected the data of two ZNF804A single-nucleotide polymorphisms (SNPs rs1344706 and rs7597593) from European and Asian populations to perform systematic meta-analyses with major mood disorders in a total of 65,240 subjects...
November 21, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27855565/impact-of-histamine-receptors-h1-and-h3-polymorphisms-on-antipsychotic-induced-weight-gain
#7
Arun K Tiwari, Danning Zhang, Jennie G Pouget, Clement C Zai, Nabilah I Chowdhury, Eva J Brandl, Li Qin, Natalie Freeman, Jeffrey A Lieberman, Herbert Y Meltzer, James L Kennedy, Daniel J Müller
OBJECTIVES: A positive correlation between antipsychotic-induced weight gain (AIWG) and antipsychotic drugs' antagonist effect at histamine H1 receptor (HRH1) as well as agonist effect at histamine H3 receptor (HRH3) in the brain has been consistently demonstrated. We investigated the potential impact of single-nucleotide polymorphisms (SNPs) in HRH1 and HRH3 genes on AIWG. METHODS: We analysed 40 tagSNPs in HRH1 (n = 34) and HRH3 (n = 6) in schizophrenia/schizoaffective disorder patients (n = 193) primarily treated with clozapine or olanzapine for up to 14 weeks...
November 18, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27712136/association-between-the-variability-of-the-abca13-gene-and-the-risk-of-major-depressive-disorder-and-schizophrenia-in-the-han-chinese-population
#8
Jianhua Chen, Raja Amjad Waheed Khan, Meng Wang, Kuanjun He, Qingzhong Wang, Zhiqiang Li, Wenjin Li, Zujia Wen, Zhijian Song, Jiawei Shen, Yifeng Xu, Yongyong Shi
OBJECTIVES: The ATP-binding cassette transporter superfamily is one of the largest membrane protein families, which is responsible for transportation of substances across the membranes by utilising energy. Some research has bridged the variations in ABCA13 with occurrence of psychiatric disorders. To investigate the overlapping risk conferred by ABCA13 for both major depressive disorder and schizophrenia, we analysed tag single nucleotide polymorphisms (tag SNPs). METHODS: We used TaqMan(®) technology to genotype 1045 major depressive disorder patients, 1235 schizophrenia patients and 1235 healthy controls of Han Chinese origin...
November 16, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27844618/repatriation-is-associated-with-isthmus-cingulate-cortex-reduction-in-community-dwelling-elderly
#9
Raffaella Calati, Jerome J Maller, Chantal Meslin, Jorge Lopez-Castroman, Karen Ritchie, Philippe Courtet, Sylvaine Artero
OBJECTIVES: The impact of stressful life events (SLEs) on brain anatomy is poorly understood, particularly its long-term neural consequences. We tested the hypothesis that a serious SLE (repatriation of French citizens living in Algeria in 1962) is associated with changes in brain regions previously implicated in psychopathology (hippocampus, amygdala, corpus callosum, prefrontal cortex, anterior, posterior and isthmus cingulate cortex (ICC) in a large elderly population. METHODS: Structural magnetic resonance imaging was used to acquire anatomical scans from 82 subjects repatriated from Algeria and 339 subjects without this experience or any other trauma...
November 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27844503/attentional-capture-by-physically-salient-stimuli-in-the-gamma-frequency-is-associated-with-schizophrenia-symptoms
#10
Laura Kornmayer, Gregor Leicht, Christoph Mulert
BACKGROUND: Aberrant salience mainly is attributed to excessive dopaminergic processing in the ventral striatum (Kapur 2003). Also, early sensory processing of physical salience has been shown to be associated with positive trait schizotypy (Kornmayer et al. 2015). In the present study, this is assessed in patients with schizophrenia. METHODS: The early evoked visual gamma-band response at 40Hz (GBR) was assessed for a schizophrenia patient group (N = 22) and a matched healthy control group (N = 22) applying EEG time-frequency analysis...
November 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27841086/svcam-1-sicam-1-tnf-%C3%AE-and-il-6-levels-in-bipolar-disorder-type-i-acute-longitudinal-and-therapeutic-implications
#11
Maja Pantović-Stefanović, Nataša Petronijević, Bojana Dunjić-Kostić, Milica Velimirović, Tatjana Nikolić, Vladimir Jurišić, Maja Lačković, Aleksandar Damjanović, Sanja Totić-Poznanović, Aleksandar A Jovanović, Maja Ivković
OBJECTIVES: To explore the serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular cell adhesion molecule-1 (sICAM-1), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in patients with bipolar disorder (BD), with regard to acute episode characteristics, course of the disorder, and treatment. METHODS: The study group consisted of 83 patients diagnosed with BD type I. The control group consisted of 73 healthy individuals, matched with the study group according to age, gender, and BMI...
November 14, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27832723/agitation-a-central-challenge-in-psychiatry
#12
Andreas Erfurth
No abstract text is available yet for this article.
November 11, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27807990/usefulness-of-repetitive-transcranial-magnetic-stimulation-as-a-maintenance-treatment-in-patients-with-major-depression
#13
Frédéric Haesebaert, Rémi Moirand, Anne-Marie Schott-Pethelaz, Jérôme Brunelin, Emmanuel Poulet
OBJECTIVE: To investigate the clinical efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), venlafaxine or a combination of both treatments as a maintenance treatment in patients with treatment-resistant depression (TRD). METHODS: In a 3-arm open-label study, 66 patients, including 45 remitters, who responded to rTMS (n = 25), venlafaxine (n = 22), or a combination of both treatments (n = 19) continued to receive the treatment that led to a response as a maintenance treatment over 12-month...
November 3, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27784204/evaluation-of-molecular-brain-changes-associated-with-environmental-stress-in-rodent-models-compared-to-human-major-depressive-disorder-a-proteomic-systems-approach
#14
David Alan Cox, Michael Gerd Gottschalk, Viktoria Stelzhammer, Hendrik Wesseling, Jason David Cooper, Sabine Bahn
OBJECTIVES: Rodent models of major depressive disorder (MDD) are indispensable when screening for novel treatments, but assessing their translational relevance with human brain pathology has proved difficult. METHODS: Using a novel systems approach, proteomics data obtained from post-mortem MDD anterior prefrontal cortex tissue (n =12) and matched controls (n = 23) were compared with equivalent data from three commonly used preclinical models exposed to environmental stressors (chronic mild stress, prenatal stress, social defeat)...
October 27, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27782768/extrastriatal-dopamine-d2-3-receptors-and-cortical-grey-matter-volumes-in-antipsychotic-na%C3%A3-ve-schizophrenia-patients-before-and-after-initial-antipsychotic-treatment
#15
Henrik Nørbak-Emig, Lars H Pinborg, Jayachandra M Raghava, Claus Svarer, William F C Baaré, Peter Allerup, Lars Friberg, Egill Rostrup, Birte Glenthøj, Bjørn H Ebdrup
OBJECTIVES: Long-term dopamine D2/3 receptor blockade, common to all antipsychotics, may underlie progressive brain volume changes observed in patients with chronic schizophrenia. In the present study, we examined associations between cortical volume changes and extrastriatal dopamine D2/3 receptor binding potentials (BPND) in first-episode schizophrenia patents at baseline and after antipsychotic treatment. METHODS: Twenty-two initially antipsychotic-naïve patients underwent magnetic resonance imaging (MRI), [(123)I]epidepride single-photon emission computerised tomography (SPECT), and psychopathology assessments before and after 3 months of treatment with either risperidone (N = 13) or zuclopenthixol (N = 9)...
October 26, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27782767/consensus-paper-of-the-wfsbp-task-force-on-biological-markers-criteria-for-biomarkers-and-endophenotypes-of-schizophrenia-part-iii-molecular-mechanisms
#16
Andrea Schmitt, Daniel Martins-de-Souza, Schahram Akbarian, Juliana S Cassoli, Hannelore Ehrenreich, Andre Fischer, Alfred Fonteh, Wagner F Gattaz, Michael Gawlik, Manfred Gerlach, Edna Grünblatt, Tobias Halene, Alkomiet Hasan, Kenij Hashimoto, Yong-Ku Kim, Sophie-Kathrin Kirchner, Johannes Kornhuber, Theo F J Kraus, Berend Malchow, Juliana M Nascimento, Moritz Rossner, Markus Schwarz, Johann Steiner, Leda Talib, Florence Thibaut, Peter Riederer, Peter Falkai
OBJECTIVES: Despite progress in identifying molecular pathophysiological processes in schizophrenia, valid biomarkers are lacking for both the disease and treatment response. METHODS: This comprehensive review summarises recent efforts to identify molecular mechanisms on the level of protein and gene expression and epigenetics, including DNA methylation, histone modifications and micro RNA expression. Furthermore, it summarises recent findings of alterations in lipid mediators and highlights inflammatory processes...
October 26, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27739341/is-the-molecular-clock-ticking-differently-in-bipolar-disorder-methylation-analysis-of-the-clock-gene-arntl
#17
Susanne A Bengesser, Eva Z Reininghaus, Nina Lackner, Armin Birner, Frederike T Fellendorf, Martina Platzer, Nora Kainzbauer, Bernhard Tropper, Christa Hörmanseder, Robert Queissner, Hans-Peter Kapfhammer, Sandra J Wallner-Liebmann, Robert Fuchs, Erwin Petek, Christian Windpassinger, Mario Schnalzenberger, Bernd Reininghaus, Bernd Evert, Andreas Waha
OBJECTIVES: The clock gene ARNTL is associated with the transcription activation of monoamine oxidase A according to previous literature. Thus, we hypothesised that methylation of ARNTL may differ between bipolar disorder (BD) and controls. METHODS: The methylation status of one CpG island covering the first exon of ARNTL (PS2) and one site in the 5' region of ARNTL (cg05733463) were analysed in patients with BD (n = 151) versus controls (n = 66). Methylation analysis was performed by bisulphite-conversion of DNA from fasting blood with the EpiTect Bisulfite Kit, PCR and pyrosequencing...
October 14, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27739340/difference-in-mitochondrial-dna-copy-number-in-peripheral-blood-cells-between-probands-with-autism-spectrum-disorders-and-their-unaffected-siblings
#18
Hee Jeong Yoo, Mira Park, Soon Ae Kim
OBJECTIVES: Several reports suggest that mitochondrial dysfunction is involved in the pathophysiology of autism spectrum disorders (ASD). Therefore, mitochondrial DNA (mtDNA) copy number, a common biomarker for mitochondrial dysfunction, might be associated with ASD phenotypes. METHODS: Relative mtDNA copy number in the peripheral blood cells of 100 Korean ASD patients and their unaffected sib-pairs was measured by quantitative polymerase chain reaction (qPCR). RESULTS: ASD patients had significantly higher relative mtDNA copy numbers than their unaffected sibs (P = ...
October 14, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27734750/association-of-anandamide-with-altered-binocular-depth-inversion-illusion-in-schizophrenia
#19
Anne R Reuter, J Malte Bumb, Juliane K Mueller, Cathrin Rohleder, Franziska Pahlisch, Franziska Hanke, Elisabeth Arens, F Markus Leweke, Dagmar Koethe, Emanuel Schwarz
Objectives Binocular depth inversion illusion (BDII) represents an illusion of visual perception that involves higher-order visual and cognitive processes. Its impairment has been linked to psychotic conditions and identified as a marker for at risk mental states. The endogenous cannabinoid system (ECS) is involved in various neurophysiological processes. One of its key components, anandamide, is involved in the pathophysiology of schizophrenia. Little is known about its impact on BDII alterations. Therefore, we explored associations between BDII and anandamide levels...
October 13, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27723376/ketamine-up-regulates-a-cluster-of-intronic-mirnas-within-the-serotonin-receptor-2c-gene-by-inhibiting-glycogen-synthase-kinase-3
#20
Steven F Grieco, Dmitry Velmeshev, Marco Magistri, Hagit Eldar-Finkelman, Mohammad A Faghihi, Richard S Jope, Eleonore Beurel
OBJECTIVES: We examined mechanisms that contribute to the rapid antidepressant effect of ketamine in mice that is dependent on glycogen synthase kinase-3 (GSK3) inhibition. METHODS: We measured serotonergic (5HT)-2C-receptor (5HTR2C) cluster microRNA (miRNA) levels in mouse hippocampus after administering an antidepressant dose of ketamine (10 mg/kg) in wild-type and GSK3 knockin mice, after GSK3 inhibition with L803-mts, and in learned helpless mice. RESULTS: Ketamine up-regulated cluster miRNAs 448-3p, 764-5p, 1264-3p, 1298-5p and 1912-3p (2- to 11-fold)...
October 10, 2016: World Journal of Biological Psychiatry
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