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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/28511598/silexan-in-anxiety-disorders-clinical-data-and-pharmacological-background
#1
S Kasper, W E Müller, H P Volz, H J Möller, E Koch, A Dienel
OBJECTIVE: Silexan is a lavender oil preparation available in capsules containing 80 mg. Here we review clinical trials investigating its anxiolytic efficacy, safety, and tolerability in humans as well as preclinical investigations supporting this therapeutic use. METHODS: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep...
May 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28460580/therapeutic-efficacy-of-the-ginkgo-special-extract-egb761-%C3%A2-within-the-framework-of-the-mitochondrial-cascade-hypothesis-of-alzheimer-s-disease
#2
Walter E Müller, Anne Eckert, Gunter P Eckert, Heidrun Fink, Kristina Friedland, Serge Gauthier, Robert Hoerr, Ralf Ihl, Siegfried Kasper, Hans-Jürgen Möller
OBJECTIVES: The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction as an important common pathomechanism for the whole spectrum of age-associated memory disorders from cognitive symptoms in the elderly over mild cognitive impairment to Alzheimer's dementia. Thus, a drug such as the Ginkgo special extract EGb 761(®) which improves mitochondrial function should be able to ameliorate cognitive deficits over the whole aging spectrum. METHODS: We review the most relevant publications about effects of EGb 761(®) on cognition and synaptic deficits in preclinical studies as well as on cognitive deficits in man from aging to dementia...
May 2, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28449613/emotion-recognition-and-theory-of-mind-in-schizophrenia-a-meta-analysis-of-neuroimaging-studies
#3
Martin Jáni, Tomáš Kašpárek
INTRODUCTION: Patients with schizophrenia have difficulties processing the emotional and cognitive states of others. Neuroimaging studies show inconsistent findings. METHOD: We used a seed-based d mapping meta-analytic method to explore brain activation during facial emotion recognition and theory of mind tasks in schizophrenia patients. RESULTS: The patients showed lesser recruitment of the facial emotion processing network; behavioural performance was associated with the activation of the precentral gyrus...
April 28, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28441923/lowered-pon1-activities-are-strongly-associated-with-depression-and-bipolar-disorder-recurrence-of-hypo-mania-and-depression-increased-disability-and-lowered-quality-of-life
#4
Estefania Gastaldello Moreira, Dalmo Guilherme Correia, Kamila Landucci Bonifácio, Juliana Brum de Moraes, Fernanda Liboni Cavicchioli, Carolina Sampaio Nunes, Sandra Odebrecht Vargas Nunes, Heber Odebrecht Vargas, Décio Sabbatini Barbosa, Michael Maes
BACKGROUND: Mood disorders (MD) frequently co-exist with cardiovascular disease (CVD) and immune-inflammatory and oxidative stress are important shared pathophysiological pathways. Even though there is an extensive investigation of the enzyme paraoxonase 1 (PON1) as a biomarker of susceptibility for CVD, there are only few reports studying PON1 in MD. OBJECTIVES: To determine the association between PON1 activities as well as functional genotypes and MD diagnosis, clinical characteristics and outcomes...
April 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28441915/early-life-adversity-induced-long-term-epigenetic-programming-associated-with-early-onset-of-chronic-physical-aggression-studies-in-humans-and-animals
#5
Dimitry A Chistiakov, Vladimir P Chekhonin
OBJECTIVES: To examine whether chronic physical aggression (CPA) in adulthood can be epigenetically programmed early in life due to exposure to early-life adversity. METHODS: Literature search of public databases such as PubMed/MEDLINE and Scopus. RESULTS: Children/adolescents susceptible for CPA and exposed to early-life abuse fail to efficiently cope with stress that in turn results in the development of CPA later in life. This phenomenon was observed in humans and animal models of aggression...
April 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28394697/genetic-study-of-neuregulin-1-and-receptor-tyrosine-protein-kinase-erbb-4-in-tardive-dyskinesia
#6
Clement C Zai, Arun K Tiwari, Nabilah I Chowdhury, Zeynep Yilmaz, Vincenzo de Luca, Daniel J Müller, Steven G Potkin, Jeffrey A Lieberman, Herbert Y Meltzer, Aristotle N Voineskos, Gary Remington, James L Kennedy
OBJECTIVES: Tardive dyskinesia (TD) is a movement disorder that may develop as a side effect of antipsychotic medication. The aetiology underlying TD is unclear, but a number of mechanisms have been proposed. METHODS: We investigated single-nucleotide polymorphisms (SNPs) in the genes coding for neuregulin-1 and erbB-4 receptor in our sample of 153 European schizophrenia patients for possible association with TD. RESULTS: We found the ERBB4 rs839523 CC genotype to be associated with risk for TD occurrence and increased severity as measured by the Abnormal Involuntary Movement Scale (AIMS) (P = ...
April 10, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28345388/cortisol-levels-in-fingernails-neurocognitive-performance-and-clinical-variables-in-euthymic-bipolar-i-disorder
#7
Andres Herane-Vives, Anthony J Cleare, Chin-Kuo Chang, Valeria de Angel, Andrew Papadopoulos, Susanne Fischer, Rozmin Halari, Eric Y W Cheung, Allan H Young
OBJECTIVES: Neurocognitive impairment has been found in bipolar patients. Hypercortisolemia is one possible cause but there has been no agreement on this. Previous sampling methods assessed only acute cortisol levels, whereas the association between cortisol and psychopathology might be better understood by investigating chronic levels. Fingernails are a novel method for measuring chronic cortisol concentration (CCC). Here, we measured CCC in euthymic bipolar disorder I (BD-I) patients and healthy controls using fingernails to investigate whether differences in CCC influenced neurocognitive performance...
March 27, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28337940/genome-wide-analysis-of-lps-induced-inflammatory-response-in-the-rat-ventral-hippocampus-modulatory-activity-of-the-antidepressant-agomelatine
#8
Andrea Carlo Rossetti, Maria Serena Paladini, Giorgio Racagni, Marco Andrea Riva, Annamaria Cattaneo, Raffaella Molteni
OBJECTIVES: Several studies reported that antidepressant drugs have immune-regulatory effects by acting on specific inflammatory mediators. However, considering the highly complex nature of the inflammatory response, we have adopted an unbiased genome-wide strategy to investigate the immune-regulatory activity of the antidepressant agomelatine in modulating the response to an acute inflammatory challenge. METHODS: Microarray analysis was used to identify genes modulated in the ventral hippocampus of adult rats chronically treated with agomelatine (40 mg/kg, os) before being challenged with a single injection of lipopolysaccharide (LPS; 250 μg/kg, i...
March 24, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28299981/electroconvulsive-therapy-against-the-patients-will-a-case-series
#9
Isabel Methfessel, Alexander Sartorius, David Zilles
OBJECTIVES: Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive and psychotic disorders. As patients may be subject to legal incapacity and lack of insight, treatment may be administered against the patient's will. There is only limited evidence on the use of ECT against the patient's non-autonomous will. METHODS: We report a series of eight patients who received ECT against their will in two German university medical hospitals between 2014 and 2016...
March 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28299954/working-memory-load-affects-repetitive-behaviour-but-not-cognitive-flexibility-in-adolescent-autism-spectrum-disorder
#10
Nicole Wolff, Witold X Chmielewski, Christian Beste, Veit Roessner
OBJECTIVES: Autism spectrum disorder (ASD) is associated with repetitive and stereotyped behaviour, suggesting that cognitive flexibility may be deficient in ASD. A central, yet not examined aspect to understand possible deficits in flexible behaviour in ASD relates (i) to the role of working memory and (ii) to neurophysiological mechanisms underlying behavioural modulations. METHODS: We analysed behavioural and neurophysiological (EEG) correlates of cognitive flexibility using a task-switching paradigm with and without working memory load in adolescents with ASD and typically developing controls (TD)...
March 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28281386/effects-of-depression-and-melatonergic-antidepressant-treatment-alone-and-in-combination-with-sedative-hypnotics-on-heart-rate-variability-implications-for-cardiovascular-risk
#11
Chuan-Chia Chang, Nian-Sheng Tzeng, Chin-Bin Yeh, Terry B J Kuo, San-Yuan Huang, Hsin-An Chang
OBJECTIVES: To examine heart rate variability (HRV) in unmedicated patients with major depressive disorder (MDD) and its changes after treatment with agomelatine alone and in combination with sedative-hypnotics. METHODS: We recruited 152 physically healthy, unmedicated patients with MDD and 472 age- and sex-matched healthy volunteers. Frequency-domain measures of HRV were obtained during enrolment for all participants and again for MDD patients after 6 weeks of treatment with agomelatine alone and combining sedative-hypnotics...
March 10, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28264635/lurasidone-compared-to-other-atypical-antipsychotic-monotherapies-for-bipolar-depression-a-systematic-review-and-network-meta-analysis
#12
Michael Ostacher, Daisy Ng-Mak, Pankaj Patel, Dionysios Ntais, Max Schlueter, Antony Loebel
OBJECTIVES: To assess the efficacy and tolerability of lurasidone versus other atypical antipsychotic monotherapy agents in patients with bipolar depression, using a Bayesian network meta-analysis. METHODS: Fourteen randomised clinical trials (6221 patients) of lurasidone, quetiapine (extended release and immediate release), aripiprazole, olanzapine, and ziprasidone for bipolar depression were included. Efficacy assessments included change in the Montgomery-Åsberg Depression Rating Scale (MADRS), rates of response (≥50% improvement in MADRS) and remission (MADRS ≤12 at study endpoint), and change in the Clinical Global Impressions-Bipolar Disorder-Severity (CGI-BP-S) scale...
March 7, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28521608/editorial
#13
Siegfried Kasper
No abstract text is available yet for this article.
June 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27170266/testing-differential-susceptibility-plasticity-genes-the-social-environment-and-their-interplay-in-adolescent-response-inhibition
#14
Jennifer S Richards, Alejandro Arias Vásquez, Daan van Rooij, Dennis van der Meer, Barbara Franke, Pieter J Hoekstra, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Catharina A Hartman, Jan K Buitelaar
OBJECTIVES: Impaired inhibitory control is a key feature of attention-deficit/hyperactivity disorder (ADHD). We investigated gene-environment interaction (GxE) as a possible contributing factor to response inhibition variation in context of the differential susceptibility theory. This states individuals carrying plasticity gene variants will be more disadvantaged in negative, but more advantaged in positive environments. METHODS: Behavioural and neural measures of response inhibition were assessed during a Stop-signal task in participants with (N = 197) and without (N = 295) ADHD, from N = 278 families (age M = 17...
June 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28262034/editorial
#15
Siegfried Kasper
No abstract text is available yet for this article.
April 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27458023/manic-symptom-severity-correlates-with-comt-activity-in-the-striatum-a-post-mortem-study
#16
Marco Bortolato, Consuelo Walss-Bass, Peter M Thompson, Jackob Moskovitz
OBJECTIVES: The enzyme catechol-O-methyltransferase (COMT), which catalyses the degradation of dopamine and norepinephrine, is posited to participate in the pathophysiology of bipolar disorder (BD) and schizophrenia. In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity...
April 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27419272/biological-markers-for-anxiety-disorders-ocd-and-ptsd-a-consensus-statement-part-ii-neurochemistry-neurophysiology-and-neurocognition
#17
Borwin Bandelow, David Baldwin, Marianna Abelli, Blanca Bolea-Alamanac, Michel Bourin, Samuel R Chamberlain, Eduardo Cinosi, Simon Davies, Katharina Domschke, Naomi Fineberg, Edna Grünblatt, Marek Jarema, Yong-Ku Kim, Eduard Maron, Vasileios Masdrakis, Olya Mikova, David Nutt, Stefano Pallanti, Stefano Pini, Andreas Ströhle, Florence Thibaut, Matilde M Vaghi, Eunsoo Won, Dirk Wedekind, Adam Wichniak, Jade Woolley, Peter Zwanzger, Peter Riederer
OBJECTIVE: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network...
April 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27376411/separate-and-combined-effects-of-genetic-variants-and-pre-treatment-whole-blood-gene-expression-on-response-to-exposure-based-cognitive-behavioural-therapy-for-anxiety-disorders
#18
Jonathan R I Coleman, Kathryn J Lester, Susanna Roberts, Robert Keers, Sang Hyuck Lee, Simone De Jong, Héléna Gaspar, Tobias Teismann, André Wannemüller, Silvia Schneider, Peter Jöhren, Jürgen Margraf, Gerome Breen, Thalia C Eley
OBJECTIVES: Exposure-based cognitive behavioural therapy (eCBT) is an effective treatment for anxiety disorders. Response varies between individuals. Gene expression integrates genetic and environmental influences. We analysed the effect of gene expression and genetic markers separately and together on treatment response. METHODS: Adult participants (n ≤ 181) diagnosed with panic disorder or a specific phobia underwent eCBT as part of standard care. Percentage decrease in the Clinical Global Impression severity rating was assessed across treatment, and between baseline and a 6-month follow-up...
April 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28183217/editorial
#19
Siegfried Kasper
No abstract text is available yet for this article.
March 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27905213/hepatic-lipid-and-genetic-factors-associated-with-obesity-crosstalk-with-alcohol-dependence
#20
Kimberly Goodyear, Mary R Lee, Melanie L Schwandt, Colin A Hodgkinson, Lorenzo Leggio
OBJECTIVES: Alcohol dependence represents a leading cause of mortality and morbidity. Understanding the variables that contribute to this diagnosis and its severity is critical. An overlap between factors that may predispose people to become obese and those that may increase the risk of alcohol dependence may exist. However, data in the literature are not conclusive. Therefore, this study aimed to identify the association between alcohol dependence and obesity-related factors, including biochemical and genetic factors...
March 2017: World Journal of Biological Psychiatry
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