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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/29022753/lower-heart-rate-variability-at-baseline-is-associated-with-more-consecutive-intrusive-memories-in-an-experimental-distressing-film-paradigm
#1
Felicitas Rombold-Bruehl, Christian Otte, Babette Renneberg, Anna Schmied, Frank Zimmermann-Viehoff, Katja Wingenfeld, Stefan Roepke
OBJECTIVES: First evidence suggests that lower heart rate variability (HRV) is associated with more cognitive control deficits, a risk factor for the development of intrusive memories. The aim of this study was to determine whether high-frequency (HF) and low-frequency/high-frequency (LF/HF) ratio components of HRV at rest before an intrusion-inducing stressor would predict consecutive intrusive memories. METHODS: Healthy female participants (n = 60) watched an established distressing film which induced intrusions...
October 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28984491/monitoring-for-antidepressant-associated-adverse-events-in-the-treatment-of-patients-with-major-depressive-disorder-an-international-consensus-statement
#2
Seetal Dodd, Philip B Mitchell, Michael Bauer, Lakshmi Yatham, Allan H Young, Sidney H Kennedy, Lana Williams, Trisha Suppes, Carlos Lopez Jaramillo, Madhukar H Trivedi, Maurizio Fava, A John Rush, Roger S McIntyre, Michael E Thase, Raymond W Lam, Emanuel Severus, Siegfried Kasper, Michael Berk
OBJECTIVES: These recommendations were designed to ensure safety for patients with major depressive disorder (MDD) and to aid monitoring and management of adverse effects during treatment with approved antidepressant medications. The recommendations aim to inform prescribers about both the risks associated with these treatments and approaches for mitigating such risks. METHODS: Expert contributors were sought internationally by contacting representatives of key stakeholder professional societies in the treatment of MDD (ASBDD, CANMAT, WFSBP and ISAD)...
October 6, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28971736/genetic-analysis-for-cognitive-flexibility-in-trail-making-test-in-attention-deficit-hyperactivity-disorder-patients-from-snp-gene-to-pathway
#3
Kunlin Zhang, Zili Fan, Yufeng Wang, Stephen V Faraone, Li Yang, Suhua Chang
OBJECTIVES: Investigation of the genetic basis of endophenotype and analysis the pathways with multiple genes of small effects might increase the understanding of the genetic basis of attention deficit hyperactivity disorder (ADHD). Here we aimed to explore the genetic basis of cognitive flexibility in ADHD at SNP, gene and pathway level. METHODS: The Trail-Making Test (TMT) was used to test the cognitive flexibility of 788 ADHD patients. A genome-wide association analysis of cognitive flexibility was conducted for 644,166 single nucleotide polymorphisms (SNPs)...
October 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28971725/transcranial-sonography-in-psychiatry-as-a-potential-tool-in-diagnosis-and-research
#4
Carsten Drepper, Julia Geißler, Giuseppe Pastura, Rezzak Yilmaz, Daniela Berg, Marcel Romanos, Manfred Gerlach
Objectives During the last two decades' transcranial sonography (TCS) of the brain parenchyma evolved from a pure research tool to a clinical relevant neuroimaging method especially in Parkinson's disease and related movement disorders. The aim of this systematic review is to update and summarize the published TCS findings in psychiatric disorders and critically address the question whether TCS may be a valuable tool for the diagnosis or differential diagnosis of psychiatric disorders similarly to the field of movement disorders...
October 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28854834/drd2-and-ankk1-genes-associate-with-late-onset-heroin-dependence-in-men
#5
Chang-Chih Tsou, Han-Wei Chou, Pei-Shen Ho, Shin-Chang Kuo, Chun-Yen Chen, Chang-Chih Huang, Chih-Sung Liang, Ru-Band Lu, San-Yuan Huang
OBJECTIVES: Dopamine plays an important role in reward system of heroin dependence (HD), and dopaminergic D2 receptor (DRD2) gene is a candidate for the aetiology of HD. Ankyrin repeat and kinase domain containing 1 (ANKK1) gene is proximal to DRD2 and may influence its expression. We explored whether DRD2 and ANKK1 associate with occurrence of HD, and whether the genetic variants influence personality traits in male patients with HD. METHODS: DRD2/ANKK1 polymorphisms were analysed in 950 unrelated Han Chinese male participants (601 HD patients and 349 healthy controls)...
September 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28854847/rna-sequencing-of-bipolar-disorder-lymphoblastoid-cell-lines-implicates-the-neurotrophic-factor-hrp-3-in-lithium-s-clinical-efficacy
#6
Elena Milanesi, Irena Voinsky, Adva Hadar, Ala Srouji, Carlo Maj, Tatyana Shekhtman, Michael Gershovits, Shlomit Gilad, Caterina Chillotti, Alessio Squassina, James B Potash, Thomas G Schulze, Fernando S Goes, Peter Zandi, John R Kelsoe, David Gurwitz
OBJECTIVES: Lithium remains the oldest and most effective treatment for mood stabilisation in bipolar disorder (BD), even though at least half of patients are only partially responsive or do not respond. This study aimed to identify biomarkers associated with lithium response in BD, based on comparing RNA sequencing information derived from lymphoblastoid cell lines (LCLs) of lithium-responsive (LR) versus lithium non-responsive (LNR) BD patients, to assess gene expression variations that might bear on treatment outcome...
September 22, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28922980/a-genome-wide-association-study-of-early-gamma-band-response-in-a-schizophrenia-case-control-sample
#7
Bettina Konte, Gregor Leicht, Ina Giegling, Oliver Pogarell, Susanne Karch, Annette M Hartmann, Marion Friedl, Ulrich Hegerl, Dan Rujescu, Christoph Mulert
OBJECTIVES: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity. METHODS: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315). RESULTS: No marker surpassed the threshold for genome-wide significant association...
September 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28922966/plasma-lipids-metabolism-in-mild-cognitive-impairment-and-alzheimer-s-disease
#8
Alana C Costa, Helena P G Joaquim, Orestes Forlenza, Leda L Talib, Wagner F Gattaz
OBJECTIVES: Expression of phospholipids and related molecules could provide panels of multiple biomarkers searching for the signature of Alzheimer's disease (AD). The aim of the present study was to quantify ten phospholipids and simultaneously determine phospholipase A2 (PLA2) activity in blood of mild cognitive impairment (MCI) and AD patients. METHODS: Thirty-four AD, 20 MCI and 25 controls were enrolled. The phospholipids where analysed using the AbsoluteIDQ(®) p180 Kit...
September 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28918693/cognitive-control-networks-in-ocd-a-resting-state-connectivity-study-in-unmedicated-patients-with-obsessive-compulsive-disorder-and-their-unaffected-relatives
#9
Froukje E de Vries, Stella J de Wit, Odile A van den Heuvel, Dick J Veltman, Danielle C Cath, Anton J L M van Balkom, Ysbrand D van der Werf
OBJECTIVES: Executive network deficits are putative neurocognitive endophenotypes for obsessive-compulsive disorder (OCD). Yet, unlike alterations in fronto-striatal and limbic connectivity, connectivity in the fronto-parietal (FPN) and cingulo-opercular (CON) networks involved in cognitive control has received little attention. METHODS: The coherence of FPN, CON and fronto-limbic networks was investigated in 39 unmedicated OCD patients, 16 of their unaffected siblings and 36 healthy controls using resting-state functional-connectivity MRI and a seed-based analysis approach...
September 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28914127/psychiatric-and-neurological-symptoms-in-patients-with-niemann-pick-disease-type-c-np-c-findings-from-the-international-npc-registry
#10
Olivier Bonnot, Clarissa S Gama, Eugen Mengel, Mercè Pineda, Marie T Vanier, Louise Watson, Marie Watissée, Barbara Schwierin, Marc C Patterson
OBJECTIVES: Niemann-Pick disease type C (NP-C) is a rare inherited neurovisceral disease that should be recognized by psychiatrists as a possible underlying cause of psychiatric abnormalities. This study describes NP-C patients who had psychiatric manifestations at enrolment in the international NPC Registry, a unique multicentre, prospective, observational disease registry. METHODS: Treating physicians' data entries describing psychiatric manifestations in NPC patients were coded and grouped by expert psychiatrists...
September 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28914113/erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
September 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28914102/5-httlpr-brain-derived-neurotrophic-factor-bdnf-gene-interactions-and-early-adverse-life-events-effect-on-impulsivity-in-suicide-attempters
#12
Luis Jiménez-Treviño, Pilar Alejandra Saiz, Maria Paz García-Portilla, Hilario Blasco-Fontecilla, Vladimir Carli, Miriam Iosue, Isabelle Jaussent, Jorge López-Castroman, Concepcion Vaquero-Lorenzo, Marco Sarchiapone, Enrique Baca-García, Philippe Courtet, Julio Bobes
OBJECTIVES: An expanding body of research suggests that childhood adverse experiences can lead to different negative health outcomes, including attempted suicide. Serotonergic genes such as the promoter region of the serotonin transporter gene (5-HTTLPR) have been associated both with impulsivity in suicide attempts and reactivity to environmental stress exposure. BDNF gene may play an epigenetic role. METHODS: We studied the influence of childhood stressful events and 5-HTTLPR genotype on impulsivity measured by Barratt Impulsivity Scale (BIS-10) in a multicentre sample of 1,655 suicide attempters (69...
September 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28895492/low-cardiac-vagal-tone-index-by-heart-rate-variability-differentiates-bipolar-from-major-depression
#13
Brandon Hage, Briana Britton, David Daniels, Keri Heilman, Stephen W Porges, Angelos Halaris
OBJECTIVES: Major depressive disorder (MDD) and depression in bipolar disorder (BD) are often difficult to distinguish from each other. Autonomic nervous system (ANS) dysregulation is associated with various depressive symptoms and inflammatory response disinhibition. The beat-to-beat pattern of heart rate (Heart Rate Variability) (HRV) offers a noninvasive portal to ANS function and provides a reliable index of resting cardiac vagal tone. We quantified HRV and measured inflammatory biomarkers in MDD and BD patients in an effort to derive potential diagnostic criteria for MDD and BD...
September 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28891785/attachment-style-moderates-effects-of-fkbp5-polymorphisms-and-childhood-abuse-on-posttraumatic-stress-symptoms-results-from-the-national-health-and-resilience-in-veterans-study
#14
Amanda J F Tamman, Lauren M Sippel, Shizhong Han, Yuval Neria, John H Krystal, Steven M Southwick, Joel Gelernter, Robert H Pietrzak
OBJECTIVES: To determine the main and interactive effects of four FKBP5 polymorphisms (rs9296158, rs3800373, rs1360780, and rs9470080), childhood abuse, and attachment style in predicting severity of PTSD symptoms in two independent, nationally representative samples of U.S. military veterans. METHODS: Data were analyzed from two independent samples of European American (EA) U.S. military veterans who participated in the National Health and Resilience in Veterans Study (N = 1,585 and 577 respectively)...
September 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28882088/slc7a11-xct-protein-expression-is-not-altered-in-the-depressed-brain-and-system-xc-deficiency-does-not-affect-depression-associated-behaviour-in-the-corticosterone-mouse-model
#15
Thomas Demuyser, Lauren Deneyer, Eduard Bentea, Giulia Albertini, Teresa Femenia, Laura Walrave, Hideyo Sato, Niels C Danbolt, Dimitri De Bundel, Alex Michotte, Maria Lindskog, Ann Massie, Ilse Smolders
OBJECTIVES: The cystine/glutamate antiporter (system xc-) is believed to contribute to nonvesicular glutamate release from glial cells in various brain areas. Although recent investigations implicate system xc- in mood disorders, unambiguous evidence has not yet been established. Therefore, we evaluated the possible role of system xc- in the depressive state. METHODS: We conducted a protein expression analysis of the specific subunit of system xc- (xCT) in brain regions of the corticosterone mouse model, Flinders Sensitive Line rat model and post-mortem tissue of depressed patients...
September 8, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28721741/the-relevance-of-hippocampal-subfield-integrity-and-clock-drawing-test-performance-for-the-diagnosis-of-alzheimer-s-disease-and-mild-cognitive-impairment
#16
Dusan Hirjak, Fabio Sambataro, Barbara Remmele, Katharina M Kubera, Johannes Schröder, Ulrich Seidl, Anne K Thomann, Klaus H Maier-Hein, Robert C Wolf, Philipp A Thomann
OBJECTIVES: The clock drawing test (CDT) is one of the worldwide most used screening tests for Alzheimer's disease (AD). MRI studies have identified temporo-parietal regions being involved in CDT impairment. However, the contributions of specific hippocampal subfields and adjacent extrahippocampal structures to CDT performance in AD and mild cognitive impairment (MCI) have not been investigated so far. It is unclear whether morphological alterations or CDT score, or a combination of both, are able to predict AD...
August 31, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28797215/the-cadm2-gene-is-associated-with-processing-speed-performance-evidence-among-elderly-with-type-2-diabetes
#17
Lior Greenbaum, Ramit Ravona-Springer, Abigail Livny, Shahar Shelly, Inbal Sharvit-Ginon, Ithamar Ganmore, Anna Alkelai, Anthony Heymann, Michal Schnaider Beeri
OBJECTIVES: Recent large scale meta-analysis of genome wide association studies (GWAS) from multiple cohorts, demonstrated the association of the single nucleotide polymorphism (SNP) rs17518584, with processing speed (measured by the Digit Symbol Substitution Task (DSST) or the Letter Digit Substitution Test (LDST)), at GWAS significance level. This SNP is located within the cell adhesion molecule 2 (CADM2) gene. We aimed to validate this finding in our sample of 944 cognitively normal Jewish elderly individuals with type 2 diabetes (T2D), a population which is at risk for cognitive decline and dementia...
August 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28797200/the-polymorphism-of-dopamine-receptor-d4-drd4-and-dopamine-transporter-dat-genes-in-the-men-with-antisocial-behavior-and-mixed-martial-arts-fighters
#18
Elena Cherepkova, Vladimir Maksimov, Alexandr Kushnarev, Igor Shakhmatov, Lyubomir I Aftanas
OBJECTIVES: VNTR polymorphisms of DRD4 and DAT genes were studied in the Russian and Chechen men convicted of crimes, and two control groups comprised of the MMA fighters and a sample of general population. A group of MMA fighters included only the subjects without history of antisocial behavior. METHODS: DNA was isolated by phenol-chloroform extraction from the blood. Genotyping VNTR polymorphisms of the DRD4 and DAT genes were performed by PCR on published methods...
August 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28789578/accelerated-itbs-treatment-in-depressed-patients-differentially-modulates-reward-system-activity-based-on-anhedonia
#19
Romain Duprat, Guo-Rong Wu, Rudi De Raedt, Chris Baeken
OBJECTIVES: Accelerated intermittent theta-burst stimulation (aiTBS) anti-depressive working mechanisms are still unclear. Because aiTBS may work through modulating the reward system and the level of anhedonia may influence this modulation, we investigated the effect of aiTBS on reward responsiveness in high and low anhedonic MDD patients. METHODS: In this registered RCT (NCT01832805), 50 MDD patients were randomised to a sham-controlled cross-over aiTBS treatment protocol over the left dorsolateral prefrontal cortex (DLPFC)...
August 9, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28714751/antidepressant-efficacy-of-electroconvulsive-therapy-is-associated-with-a-reduction-of-the-innate-cellular-immune-activity-in-the-cerebrospinal-fluid-in-patients-with-depression
#20
Laura Kranaster, Carolin Hoyer, Suna S Aksay, Jan Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
August 9, 2017: World Journal of Biological Psychiatry
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