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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/29425059/prader-willi-syndrome-and-angelman-syndrome-visualisation-of-the-molecular-pathways-for-two-chromosomal-disorders
#1
Friederike Ehrhart, Kelly J M Janssen, Susan L Coort, Chris T Evelo, Leopold M G Curfs
OBJECTIVES: Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are two syndromes that are caused by the same chromosomal deletion on 15q11.2-q13. Due to methylation patterns, different genes are responsible for the two distinct phenotypes resulting in the disorders. Patients of both disorders exhibit hypotonia in neonatal stage, delay in development and hypopigmentation. Typical features for PWS include hyperphagia, which leads to obesity, the major cause of mortality, and hypogonadism...
February 9, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29383983/the-role-of-the-gut-microbiota-in-schizophrenia-current-and-future-perspectives
#2
Daniela Rodrigues-Amorim, Tania Rivera-Baltanás, Benito Regueiro, Carlos Spuch, María Elena de Las Heras, Raul Váquez-Noguerol Méndez, Maria Nieto-Araujo, C Barreiro-Villar, Jose M Olivares, Roberto C Agís-Balboa
OBJECTIVES: Schizophrenia is a poorly understood chronic disease. Its pathophysiology is complex, dynamic, and linked to epigenetic mechanisms and microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing, to its multidimensional implications: temporal and spatial variability. Microbiota involvement and epigenetic mechanisms are factors that are currently being considered to better understand another dimension of schizophrenia. METHODS: This review summarizes and discusses currently available information, focusing on the microbiota, epigenetic mechanisms, technological approaches aimed at performing exhaustive analyses of the microbiota, and psychotherapies, to establish future perspectives...
January 31, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29380665/repeated-cocaine-exposure-dysregulates-bdnf-expression-and-signaling-in-the-mesocorticolimbic-pathway-of-the-adolescent-rat
#3
Lucia Caffino, Giuseppe Giannotti, Giulia Messa, Francesca Mottarlini, Fabio Fumagalli
OBJECTIVES: Long-term abstinence following cocaine exposure up-regulates BDNF expression in the mesocorticolimbic pathway. Given the increased vulnerability to drug abuse typical of adolescence, we hypothesized that changes in BDNF expression may become manifest early after the end of cocaine treatment in the adolescent brain. METHODS: Rats received cocaine injections from postnatal day 28 (PND28) to PND42 and the mesocorticolimbic expression of BDNF was measured by real-time PCR and Western blotting at PND43...
January 30, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29376462/salivary-cortisol-as-predictor-for-depression-characteristics-and-remission-in-electroconvulsive-therapy-in-older-persons
#4
Danii L S Suijk, Annemieke Dols, Eric van Exel, Max L Stek, Eveline Veltman, Filip Bouckaert, Pascal Sienaert, Didi Rhebergen
OBJECTIVES: Electroconvulsive therapy (ECT) is the most effective treatment for depression, however consensus on predictors for ECT-outcome is lacking. We aim to examine the relation between pre-ECT salivary cortisol values and clinical characteristics and ECT-outcome in depressed, older persons. METHODS: 102 inpatients meeting DSM-IV-criteria for depression and referred for ECT were selected. Salivary cortisol was assessed at 5 time points during the day, providing insight into the cortisol awakening curve to the ground (AUCg) and to the increase (AUCi) and evening cortisol level...
January 29, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29376460/anxiety-disorders-and-crp-in-a-population-cohort-study-with-54326-participants-the-lifelines-study
#5
Petrus J W Naudé, Annelieke M Roest, Dan J Stein, Peter de Jonge, Bennard Doornbos
Objectives - Growing evidence indicates that inflammatory processes may play a role in the pathogenesis of anxiety disorders. Nevertheless, much remains to be learned about the involvement of inflammation, including C-reactive protein (CRP), in specific anxiety disorders. This study examines the relation between anxiety disorders and CRP. Methods - Associations of serum CRP with anxiety disorders were determined in a large population study (n = 54,326 participants, mean age = 47 years; 59% female), the LifeLines cohort...
January 29, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29364039/neurophysiological-correlate-of-emotional-regulation-in-cognitive-and-motor-deficits-in-tourette-s-syndrome
#6
Navkiran Kalsi, Renata Tambelli, Daniela Altavilla, Cristina Trentini, Sara Panunzi, Mariella Stanca, Paola Aceto, Francesco Cardona, Carlo Lai
OBJECTIVES: The present study investigated the role of different emotions in the expression of cognitive and motor control abilities of children having Tourette's Syndrome (TS) compared to healthy controls. METHODS: The electroencephalography (EEG) activity of thirty-three children (mean age in final sample: TS (n = 10)=10.5±2.3; control (n = 10)=10.1±2.9) was recorded during a visual task consisting of four emotional face cues (anger, happiness, neutral and sadness) followed by a target in congruent or incongruent position with emotional cue...
January 24, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29353534/no-detectable-effects-of-acute-tryptophan-depletion-on-short-term-immune-system-cytokine-levels-in-healthy-adults
#7
Caroline S Biskup, Katrin Helmbold, Maike Linden, Karl-Josef Langen, C P Filss, Kevin C Runions, Richard M Stewart, Pradeep Rao, Julie K Moore, Simone Mahfouda, Hugo A E Morandini, Janice W Y Wong, Lothar Rink, Florian D Zepf
Recent research suggested an influence of diminished central nervous serotonin (5-HT) synthesis on the leptin axis via immunological mechanisms in healthy adult females. However, studies assessing immunological parameters in combination with dietary challenge techniques that impact brain 5-HT synthesis in humans are lacking. In the present trial, a pilot analysis was conducted on data obtained in healthy adult humans receiving either different dietary acute tryptophan depletion (ATD) challenge or tryptophan (TRP)-balanced control conditions (BAL) to study the effects of reduced central nervous 5-HT synthesis on serum TNF-α, IL-1β beta and IL-6 concentrations...
January 22, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29353531/oxytocin-receptor-gene-variation-behavioural-inhibition-and-adult-separation-anxiety-role-in-complicated-grief
#8
Miriam A Schiele, Barbara Costa, Marianna Abelli, Claudia Martini, David S Baldwin, Katharina Domschke, Stefano Pini
OBJECTIVES: Complicated grief (CG) following bereavement significantly increases the risk for mood and anxiety disorders. The severity of grief reactions may be interactively influenced by temperamental and psychological factors such as behavioural inhibition (BI) and separation anxiety (SA) as well as biological factors. Given its central role in attachment and stress processing, a genetic variant in the oxytocin receptor (OXTR) gene was thus investigated in order to elucidate the direction of association as well as its interaction with BI and SA in the moderation of CG severity...
January 22, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29345509/corrigendum
#9
(no author information available yet)
No abstract text is available yet for this article.
January 18, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29338494/neural-correlates-of-response-inhibition-in-patients-with-bipolar-disorder-during-acute-vs-remitted-phase
#10
Juliane Kopf, Stefan Glöckner, Martin Schecklmann, Thomas Dresler, Michael M Plichta, Julia Veeh, Sarah Kittel-Schneider, Andreas Reif
OBJECTIVE: Elevated behavioral impulsivity has been shown to be a core feature of bipolar disorder. However, no study has so far investigated impulsivity-related brain activation in patients with BD during acute vs. remitted phase. To address the question whether elevated behavioural impulsivity and its differential neural pathways is a state or trait marker of BD, we employed a combined stop-signal-go/nogo task in 30 controls, 37 depressed and 15 remitted patients who were retested. METHODS: Frontal brain activation was recorded using near-infrared spectroscopy...
January 17, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29334322/plasma-brain-derived-neurotrophic-factor-pbdnf-and-executive-dysfunctions-in-patients-with-major-depressive-disorder
#11
Stefanie Wagner, Sarah Kayser, Jan Engelmann, Konrad F Schlicht, Nadine Dreimüller, Oliver Tüscher, Florian Müller-Dahlhaus, Dieter F Braus, André Tadić, Alexandra Neyazi, Helge Frieling, Klaus Lieb
OBJECTIVES: Executive dysfunctions are frequently seen in patients with Major Depressive Disorder (MDD) and normalize in many cases during effective antidepressant therapy. This study investigated whether a normalization of executive dysfunctions during antidepressant treatment correlates with or can be predicted by clinical parameters or levels of brain-derived neurotrophic factor (BDNF). METHODS: In 110 MDD patients with executive dysfunctions (percentile < 16), executive functions and plasma BDNF levels were analysed at baseline, day 14 and 56 of an antidepressant treatment...
January 15, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29243550/attention-deficit-hyperactivity-disorder-is-associated-with-reduced-levels-of-serum-low-density-lipoprotein-cholesterol-in-adolescents-data-from-the-population-based-german-kiggs-study
#12
Raquel Pinho, Biyao Wang, Andreas Becker, Aribert Rothenberger, Tiago F Outeiro, Christoph Herrmann-Lingen, Thomas Meyer
OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial, complex and the most common neurodevelopmental disorder in childhood. In this analysis, we tested the hypothesis that altered serum lipid patterns are associated with ADHD. METHODS: Using data from the nationwide, population-based German Health Interview and Examination Survey for Children and Adolescents (KiGGS), we compared serum levels of total cholesterol, high-density (HDL) and low-density lipoprotein (LDL) cholesterol, and also triglycerides, in participants with physician-diagnosed and/or suspected ADHD, as defined by a value of ≥7 on the hyperactivity-inattention subscale of the Strengths and Difficulties Questionnaire (SDQ), with non-ADHD controls...
January 11, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29251065/the-potential-influence-of-led-lighting-on-mental-illness
#13
Michael Bauer, Tasha Glenn, Scott Monteith, John F Gottlieb, Philipp Ritter, John Geddes, Peter C Whybrow
OBJECTIVES: Two recent scientific breakthroughs may alter the treatment of mental illness, as discussed in this narrative review. First, the invention of white light-emitting diodes (LEDs) enabled an ongoing, rapid transition to energy-efficient LEDs for lighting, and the use of LEDs to backlight digital devices. Second was the discovery of melanopsin-expressing photosensitive retinal ganglion cells, which detect environmental irradiance and mediate non-image forming (NIF) functions including circadian entrainment, melatonin secretion, alertness, sleep regulation and the pupillary light reflex...
December 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29243543/a-kainate-receptor-gluk4-deletion-protective-against-bipolar-disorder-is-associated-with-enhanced-cognitive-performance-across-diagnoses-in-the-twinsuk-cohort
#14
Maria Koromina, Miles Flitton, Ian Mellor, Helen Miranda Knight
OBJECTIVES: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals from the TwinsUK study. METHODS: Cognitive performance was assessed using the National Adult Reading Test, four CANTAB tests (Spatial Working Memory, Paired Associates Learning, Pattern Recognition Memory, and Reaction Time), and two Principal Component Analysis derived factors...
December 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29235890/low-density-lipoprotein-cholesterol-and-suicidal-behaviour-in-a-large-sample-of-first-episode-psychosis-patients
#15
Rosa Ayesa-Arriola, Manuel Canal Rivero, Manuel Delgado-Alvarado, Esther Setién-Suero, Jana González-Gómez, Javier Labad, Anthony S David, Benedicto Crespo-Facorro
OBJECTIVES: Our aims were to confirm the relationship between lipid and lipoprotein concentrations and suicidal behaviour in first episode psychosis (FEP) patients. METHODS: Suicidal behaviour was explored in a large FEP sample (N = 383). Baseline lipid profile was compared between those who attempted or completed suicide and those who not presented suicidal behaviour. RESULTS: Low-density lipoprotein cholesterol (LDL-c) (OR = 0.99, 95% CI= 0...
December 13, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29182037/drd4-exon-3-genotype-and-adhd-randomized-pharmacodynamic-investigation-of-treatment-response-to-methylphenidate
#16
Darya Naumova, Natalie Grizenko, Sarojini M Sengupta, Ridha Joober
OBJECTIVES: Dopamine plays an important role in modulating attention and motor behaviors, dimensions altered in attention deficit/hyperactivity disorder (ADHD). Numerous association studies have linked dopamine receptor 4 (DRD4) to increased risk of ADHD. This study investigated the effect of DRD4 exon 3 polymorphism on child behaviours in response to treatment with methylphenidate (MPH). METHODS: 374 children diagnosed with ADHD (ages 6-12) were evaluated under three experimental conditions: baseline, placebo and MPH (0...
November 28, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29172938/corrigendum
#17
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29388889/editorial
#18
Siegfried Kasper
No abstract text is available yet for this article.
March 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29345544/editorial
#19
Siegfried Kasper
No abstract text is available yet for this article.
February 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29111868/editorial
#20
Siegfried Kasper
No abstract text is available yet for this article.
December 2017: World Journal of Biological Psychiatry
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