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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/28337940/genome-wide-analysis-of-lps-induced-inflammatory-response-in-the-rat-ventral-hippocampus-modulatory-activity-of-the-antidepressant-agomelatine
#1
Andrea Carlo Rossetti, Maria Serena Paladini, Giorgio Racagni, Marco Andrea Riva, Annamaria Cattaneo, Raffaella Molteni
OBJECTIVES: Several studies reported that antidepressant drugs have immune-regulatory effects by acting on specific inflammatory mediators. However, considering the highly complex nature of the inflammatory response, we have adopted an unbiased genome-wide strategy to investigate the immune-regulatory activity of the antidepressant agomelatine in modulating the response to an acute inflammatory challenge. METHODS: Microarray analysis was used to identify genes modulated in the ventral hippocampus of adult rats chronically treated with agomelatine (40 mg/kg, os) before being challenged with a single injection of lipopolysaccharide (LPS; 250 μg/kg, i...
March 24, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28299981/electroconvulsive-therapy-against-the-patients-will-a-case-series
#2
Isabel Methfessel, Alexander Sartorius, David Zilles
OBJECTIVES: Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive and psychotic disorders. As patients may be subject to legal incapacity and lack of insight, treatment may be administered against the patient's will. There is only limited evidence on the use of ECT against the patient's non-autonomous will. METHODS: We report a series of eight patients who received ECT against their will in two German university medical hospitals between 2014 and 2016...
March 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28299954/working-memory-load-affects-repetitive-behaviour-but-not-cognitive-flexibility-in-adolescent-autism-spectrum-disorder
#3
Nicole Wolff, Witold X Chmielewski, Christian Beste, Veit Roessner
OBJECTIVES: Autism spectrum disorder (ASD) is associated with repetitive and stereotyped behaviour, suggesting that cognitive flexibility may be deficient in ASD. A central, yet not examined aspect to understand possible deficits in flexible behaviour in ASD relates (i) to the role of working memory and (ii) to neurophysiological mechanisms underlying behavioural modulations. METHODS: We analysed behavioural and neurophysiological (EEG) correlates of cognitive flexibility using a task-switching paradigm with and without working memory load in adolescents with ASD and typically developing controls (TD)...
March 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28281386/effects-of-depression-and-melatonergic-antidepressant-treatment-alone-and-in-combination-with-sedative-hypnotics-on-heart-rate-variability-implications-for-cardiovascular-risk
#4
Chuan-Chia Chang, Nian-Sheng Tzeng, Chin-Bin Yeh, Terry B J Kuo, San-Yuan Huang, Hsin-An Chang
OBJECTIVES: To examine heart rate variability (HRV) in unmedicated patients with major depressive disorder (MDD) and its changes after treatment with agomelatine alone and in combination with sedative-hypnotics. METHODS: We recruited 152 physically healthy, unmedicated patients with MDD and 472 age- and sex-matched healthy volunteers. Frequency-domain measures of HRV were obtained during enrolment for all participants and again for MDD patients after 6 weeks of treatment with agomelatine alone and combining sedative-hypnotics...
March 10, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28264635/lurasidone-compared-to-other-atypical-antipsychotic-monotherapies-for-bipolar-depression-a-systematic-review-and-network-meta-analysis
#5
Michael Ostacher, Daisy Ng-Mak, Pankaj Patel, Dionysios Ntais, Max Schlueter, Antony Loebel
OBJECTIVES: To assess the efficacy and tolerability of lurasidone versus other atypical antipsychotic monotherapy agents in patients with bipolar depression, using a Bayesian network meta-analysis. METHODS: Fourteen randomised clinical trials (6221 patients) of lurasidone, quetiapine (extended release and immediate release), aripiprazole, olanzapine, and ziprasidone for bipolar depression were included. Efficacy assessments included change in the Montgomery-Åsberg Depression Rating Scale (MADRS), rates of response (≥50% improvement in MADRS) and remission (MADRS ≤12 at study endpoint), and change in the Clinical Global Impressions-Bipolar Disorder-Severity (CGI-BP-S) scale...
March 7, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28155577/neurobiology-of-depression-a-neurodevelopmental-approach
#6
Juan M Lima-Ojeda, Rainer Rupprecht, Thomas C Baghai
OBJECTIVES: The main aims of this paper are to review and evaluate the neurobiology of the depressive syndrome from a neurodevelopmental perspective. METHODS: An English language literature search was performed using PubMed. RESULTS: Depression is a complex syndrome that involves anatomical and functional changes that have an early origin in the brain development. In subjects with genetic risk for depression, early stress factors are able to mediate not only the genetic risk but also the gene expression...
February 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090806/randomised-sham-controlled-study-of-high-frequency-bilateral-deep-transcranial-magnetic-stimulation-dtms-to-treat-adult-attention-hyperactive-disorder-adhd-negative-results
#7
Yaniv Paz, Keren Friedwald, Yeheal Levkovitz, Abraham Zangen, Uri Alyagon, Uri Nitzan, Aviv Segev, Hagai Maoz, May Koubi, Yuval Bloch
OBJECTIVES: Recent studies support the possible effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for attention deficit hyperactivity disorder (ADHD). The objective of this study was to evaluate the safety and possible efficacy of bilateral prefrontal deep rTMS for the treatment of adult ADHD. METHODS: Twenty-six adult ADHD patients were randomised blindly to sham or actual deep TMS (dTMS). Twenty daily sessions were conducted using the bilateral H5 dTMS coil (Brainsway, IL) in order to stimulate the prefrontal cortex at 120% of the motor threshold at high frequency...
January 31, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28132573/reduced-astrocyte-density-underlying-brain-volume-reduction-in-activity-based-anorexia-rats
#8
Linda Frintrop, Johanna Liesbrock, Lisa Paulukat, Sonja Johann, Martien J Kas, Rene Tolba, Nicole Heussen, Joseph Neulen, Kerstin Konrad, Beate Herpertz-Dahlmann, Cordian Beyer, Jochen Seitz
OBJECTIVES: Severe grey and white matter volume reductions were found in patients with anorexia nervosa (AN) that were linked to neuropsychological deficits while their underlying pathophysiology remains unclear. For the first time, we analysed the cellular basis of brain volume changes in an animal model (activity-based anorexia, ABA). METHODS: Female rats had 24 h/day running wheel access and received reduced food intake until a 25% weight reduction was reached and maintained for 2 weeks...
January 30, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28120636/the-influence-of-childhood-abuse-on-cortisol-levels-and-the-cortisol-awakening-response-in-depressed-and-nondepressed-older-adults
#9
Ilse Wielaard, Roxanne Schaakxs, Hannie C Comijs, Max L Stek, Didi Rhebergen
OBJECTIVES: Childhood abuse has been associated with depression in later life. This may be related to hypothalamic-pituitary-adrenal (HPA) axis functioning. Therefore we aimed to examine the impact of childhood abuse and its interaction with depression on cortisol levels in older adults. METHODS: Data from 418 participants (mean age 70.8 years) in the Netherlands Study of Depression in Older Persons (NESDO) were used; 187 participants experienced childhood abuse; 309 participants had a diagnosis of depression...
January 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28112047/venous-thromboembolism-during-treatment-with-antipsychotics-results-of-a-drug-surveillance-program
#10
Martin Letmaier, Renate Grohmann, Christiana Kren, Sermin Toto, Stefan Bleich, Rolf Engel, Thomas Gary, Konstantinos Papageorgiou, Anastasios Konstantinidis, Anna Katharina Holl, Annamaria Painold, Siegfried Kasper
OBJECTIVES: Venous thromboembolism (VTE) can be a life-threatening medical condition that may lead to leg swelling, respiratory distress and death. METHODS: The AMSP (Arzneimittelsicherheit in der Psychiatrie) is a continuous multicenter drug surveillance program that assesses severe adverse drug reactions during treatment of psychiatric inpatients. We report on a total of 264,422 inpatients who were treated with antipsychotics (APs) and monitored from 1993 to 2011 in 99 psychiatric hospitals...
January 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28112043/genetics-of-schizophrenia-a-consensus-paper-of-the-wfsbp-task-force-on-genetics
#11
Ina Giegling, Ladislav Hosak, Rainald Mössner, Alessandro Serretti, Frank Bellivier, Stephan Claes, David A Collier, Alejo Corrales, Lynn E DeLisi, Carla Gallo, Michael Gill, James L Kennedy, Marion Leboyer, Wolfgang Maier, Miguel Marquez, Isabelle Massat, Ole Mors, Pierandrea Muglia, Markus M Nöthen, Jorge Ospina-Duque, Michael J Owen, Peter Propping, YongYong Shi, David St Clair, Florence Thibaut, Sven Cichon, Julien Mendlewicz, Michael C O'Donovan, Dan Rujescu
OBJECTIVES: Schizophrenia is a severe psychiatric disease affecting about 1% of the general population. The relative contribution of genetic factors has been estimated to be up to 80%. The mode of inheritance is complex, non-Mendelian, and in most cases involving the combined action of large numbers of genes. METHODS: This review summarises recent efforts to identify genetic variants associated with schizophrenia detected, e.g., through genome-wide association studies, studies on copy-number variants or next-generation sequencing...
January 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28112029/two-patterns-of-anterior-insular-cortex-functional-connectivity-in-bipolar-disorder-and-schizophrenia
#12
Jian Li, Yanqing Tang, Fay Womer, Guoguang Fan, Qian Zhou, Wenge Sun, Ke Xu, Fei Wang
OBJECTIVES: Bipolar disorder (BD) and schizophrenia (SZ) share structural abnormalities in the anterior insula cortex (AIC). The AIC appears to have a crucial role in emotional processing and regulation and cognitive control in BD and SZ. METHODS: Forty-six participants with BD, 68 with SZ and 66 healthy controls (HC) underwent functional magnetic resonance imaging scanning. Resting-state functional connectivity (rsFC) from AIC subregions (ventral and dorsal) was compared among the three groups...
January 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28112021/is-there-a-role-for-cannabidiol-in-psychiatry
#13
Julia Machado Khoury, Maila de Castro Lourenço das Neves, Marco Antônio Valente Roque, Daniela Alves de Brito Queiroz, André Augusto Corrêa de Freitas, Ângelo de Fátima, Fabrício Moreira, Frederico Duarte Garcia
OBJECTIVES: Understanding if cannabidiol (CBD) is a useful and safe for the treatment of psychiatric disorders is essential to empower psychiatrists and patients to take good clinical decisions. Our aim was to conduct a systematic review regarding the benefits and adverse events (AEs) of CBD in the treatment of schizophrenia, psychotic disorders, anxiety disorders, depression, bipolar disorder and substance use disorders. METHODS: We conducted a literature search in PubMed, Scielo, and Clinicaltrials...
January 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28105895/prefrontal-cortex-dysfunction-in-hypoxic-ischaemic-encephalopathy-contributes-to-executive-function-impairments-in-rats-potential-contribution-for-attention-deficit-hyperactivity-disorder
#14
Patrícia Maidana Miguel, Bruna Ferrary Deniz, Iohanna Deckmann, Heloísa Deola Confortim, Ramiro Diaz, Daniela Pereira Laureano, Patrícia Pelufo Silveira, Lenir Orlandi Pereira
OBJECTIVES: The attention-deficit/hyperactivity disorder (ADHD) compromises the quality of life of individuals including adaptation to the social environment. ADHD aetiology includes perinatal conditions such as hypoxic-ischaemic events; preclinical studies have demonstrated attentional deficits and impulsive-hyperactive outcomes after neonatal hypoxic and/or ischaemic intervention, but data are missing to understand this relationship. Thus, the aim of this study was to evaluate executive function (EF) and impulsivity, and tissue integrity and dopaminergic function in the prefrontal cortex (PFC) of rats submitted to hypoxia-ischaemia (HI)...
January 20, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28097908/common-and-specific-genes-and-peripheral-biomarkers-in-children-and-adults-with-attention-deficit-hyperactivity-disorder
#15
Cristian Bonvicini, Stephen V Faraone, Catia Scassellati
OBJECTIVES: Elucidating the biological mechanisms involved in Attention-deficit/hyperactivity disorder (ADHD) has been challenging. Relatively unexplored is the fact that these mechanisms can differ with age. METHODS: We present an overview on the major differences between children and adults with ADHD, describing several studies from genomics to metabolomics performed in ADHD children and in adults. A systematic search (up until February, 2016) was conducted. RESULTS: From a PRISMA flow-chart, a total of eligibility 350 studies from genomics and metabolomics were found for cADHD and 91 for aADHD...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28095742/lithium-response-in-bipolar-disorders-and-core-clock-genes-expression
#16
Pierre A Geoffroy, Emmanuel Curis, Cindie Courtin, Jeverson Moreira, Thomas Morvillers, Bruno Etain, Jean-Louis Laplanche, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: We examine if the lithium response is associated with changes in core clock genes expressions. METHODS: The effect of a therapeutic concentration of lithium (1mM) on the expression levels of 17 circadian genes, was examined in lymphoblastoid cell lines (LCLs) derived from two well-characterized groups of BD patients, defined as lithium non-responders (NR, n = 20) or excellent responders (ER, n = 16). Quantitative real-time PCR (qRT-PCR) were conducted at 2, 4 and 8 days (d2, d4, d8) with and without lithium exposure...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090807/neurocognitive-function-in-pediatric-obsessive-compulsive-disorder
#17
Daniel A Geller, Amitai Abramovitch, Andrew Mittelman, Abigail Stark, Kesley Ramsey, Allison Cooperman, Lee Baer, S Evelyn Stewart
OBJECTIVES: The small body of neuropsychological research in pediatric OCD yields inconsistent results. A recent meta-analysis found small effect sizes, concluding that pediatric OCD may not be associated with cognitive impairments, stressing the need for more research. We investigated neuropsychological performance in a large sample of OCD youth, while assessing potential moderators. METHODS: Participants with OCD (n = 102), and matched controls (n = 161) were thoroughly screened and blindly evaluated for comorbidities, and completed a neuropsychological battery assessing processing-speed, visuospatial abilities (VSA), working memory (WM), nonverbal memory (NVM), and executive functions (EF)...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090804/choline-acetyltransferase-may-contribute-to-the-risk-of-tourette-syndrome-combination-of-family-based-analysis-and-case-control-study
#18
Xiuling Yang, Wenmiao Liu, Mingji Yi, Ru Zhang, Yinglei Xu, Zuzhou Huang, Shiguo Liu, Tang Li
OBJECTIVES: Twin and family analyses have revealed a genetic contribution to Tourette syndrome and postmortem studies have raised the intriguing possibility of a reduction in cholinergic interneuronsin TS patients. METHODS: We selected five tag SNPs (rs100824791, rs12264845, rs1880676, rs3793790 and rs3793798) of Choline Acetyltransferase (CHAT) from the Han Chinese population Hapmap database. Genotyping was conducted on 401 TS nuclear family trios and 405 control subjects...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090803/insulin-like-growth-factor-binding-protein-2-in-bipolar-disorder-an-expression-study-in-peripheral-tissues
#19
Elena Milanesi, Roberta Zanardini, Gianluca Rosso, Giuseppe Maina, Alessandro Barbon, Cristina Mora, Alessandra Minelli, Massimo Gennarelli, Luisella Bocchio-Chiavetto
OBJECTIVES: Insulin-like Growth Factor Binding Protein 2 (IGFBP2) is a member of the family of high-affinity binding proteins (IGFBP1-6) and appears to play a governing role in Insulin-like Growth Factor (IGF) regulation in the central nervous system. This study aimed to investigate the putative involvement of IGFBP2 in mood disorder pathogenesis by measuring its expression levels in patient peripheral tissues. METHODS: IGFBP2 protein and mRNA levels were measured in the serum of 93 controls, 41 Bipolar Disorder (BD) and 43 Major Depressive Disorder (MDD) patients and in the skin fibroblasts from 15 controls, 12 BD and 23 MDD patients...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28262034/editorial
#20
Siegfried Kasper
No abstract text is available yet for this article.
April 2017: World Journal of Biological Psychiatry
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