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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/28797215/the-cadm2-gene-is-associated-with-processing-speed-performance-evidence-among-elderly-with-type-2-diabetes
#1
Lior Greenbaum, Ramit Ravona-Springer, Abigail Livny, Shahar Shelly, Inbal Sharvit-Ginon, Ithamar Ganmore, Anna Alkelai, Anthony Heymann, Michal Schnaider Beeri
OBJECTIVES: Recent large scale meta-analysis of genome wide association studies (GWAS) from multiple cohorts, demonstrated the association of the single nucleotide polymorphism (SNP) rs17518584, with processing speed (measured by the Digit Symbol Substitution Task (DSST) or the Letter Digit Substitution Test (LDST)), at GWAS significance level. This SNP is located within the cell adhesion molecule 2 (CADM2) gene. We aimed to validate this finding in our sample of 944 cognitively normal Jewish elderly individuals with type 2 diabetes (T2D), a population which is at risk for cognitive decline and dementia...
August 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28797200/the-polymorphism-of-dopamine-receptor-d4-drd4-and-dopamine-transporter-dat-genes-in-the-men-with-antisocial-behavior-and-mixed-martial-arts-fighters
#2
Elena Cherepkova, Vladimir Maksimov, Alexandr Kushnarev, Igor Shakhmatov, Lyubomir I Aftanas
OBJECTIVES: VNTR polymorphisms of DRD4 and DAT genes were studied in the Russian and Chechen men convicted of crimes, and two control groups comprised of the MMA fighters and a sample of general population. A group of MMA fighters included only the subjects without history of antisocial behavior. METHODS: DNA was isolated by phenol-chloroform extraction from the blood. Genotyping VNTR polymorphisms of the DRD4 and DAT genes were performed by PCR on published methods...
August 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28789578/accelerated-itbs-treatment-in-depressed-patients-differentially-modulates-reward-system-activity-based-on-anhedonia
#3
Romain Duprat, Guo-Rong Wu, Rudi De Raedt, Chris Baeken
OBJECTIVES: Accelerated intermittent theta-burst stimulation (aiTBS) anti-depressive working mechanisms are still unclear. Because aiTBS may work through modulating the reward system and the level of anhedonia may influence this modulation, we investigated the effect of aiTBS on reward responsiveness in high and low anhedonic MDD patients. METHODS: In this registered RCT (NCT01832805), 50 MDD patients were randomised to a sham-controlled cross-over aiTBS treatment protocol over the left dorsolateral prefrontal cortex (DLPFC)...
August 9, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28741401/trans-diagnostic-comparison-of-response-inhibition-in-tourette-s-disorder-and-obsessive-compulsive-disorder
#4
Siyan Fan, Danielle C Cath, Ysbrand D van der Werf, Stella de Wit, Dick J Veltman, Odile A van den Heuvel
OBJECTIVES: Impaired response inhibition is related to neurodevelopmental disorders, such as Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Unlike OCD, in which neural correlates of response inhibition have been extensively studied, TD literature is limited. By using a Stop-Signal task, we investigated the neural mechanisms underlying response inhibition deficits in TD compared to OCD and healthy controls (HCs). METHODS: Twenty-three TD patients, 20 OCD patients and 22 HCs were scanned (3T MRI)...
July 25, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28721741/the-relevance-of-hippocampal-subfield-integrity-and-clock-drawing-test-performance-for-the-diagnosis-of-alzheimer-s-disease-and-mild-cognitive-impairment
#5
Dusan Hirjak, Fabio Sambataro, Barbara Remmele, Katharina M Kubera, Johannes Schröder, Ulrich Seidl, Anne K Thomann, Klaus H Maier-Hein, Robert C Wolf, Philipp A Thomann
OBJECTIVES: The clock drawing test (CDT) is one of the worldwide most used screening tests for Alzheimer's disease (AD). MRI studies have identified temporo-parietal regions being involved in CDT impairment. However, the contributions of the hippocampal formation to CDT performance in AD and mild cognitive impairment (MCI) have not been investigated so far. It is unclear whether morphological alterations or CDT score, or a combination of both, are able to predict AD. METHODS: 38 AD patients, 38 MCI individuals and 31 healthy controls underwent neuropsychological assessment and MRI at 3 Tesla...
July 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28664816/cyp2c19-17-protects-against-metabolic-complications-of-clozapine-treatment
#6
Irina Piatkov, Dorgival Caetano, Yolinda Assur, Sue Lynn Lau, Micheline Coelho, Trudi Jones, Tristan Nguyen, Steven Boyages, Mark McLean
OBJECTIVES: Clozapine (CZ) is the most effective drug for managing treatment-resistant schizophrenic disorders. Its use has been limited due to adverse effects, which include weight gain and new-onset diabetes, but the incidence of these varies between patients. METHODS: We investigated 187 Clozapine Clinic patients (of whom 137 consented for genotyping) for the presence of CYP2C19*17 and its association with CZ and norclozapine (NCZ) levels, and clinical outcomes...
July 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28714751/antidepressant-efficacy-of-electroconvulsive-therapy-is-associated-with-a-reduction-of-the-innate-cellular-immune-activity-in-the-cerebrospinal-fluid-in-patients-with-depression
#7
Laura Kranaster, Carolin Hoyer, Suna S Aksay, J Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
July 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28699376/corrigendum
#8
(no author information available yet)
No abstract text is available yet for this article.
July 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28656803/val66met-polymorphism-association-with-serum-bdnf-and-inflammatory-biomarkers-in-major-depression
#9
Marco Antonio Caldieraro, Madison McKee, Sandra Leistner-Segal, Edgar Arrua Vares, Francyne Kubaski, Lucas Spanemberg, Ana Carolina Brusius-Facchin, Marcelo P Fleck, David Mischoulon
OBJECTIVES: Current evidence supports participation of neurotrophic and inflammatory factors in the pathogenesis of major depressive disorder (MDD). Some studies reported an association between the Val66Met polymorphism (rs6265) of brain-derived neurotrophic factor (BDNF) gene with MDD and peripheral BDNF levels. However, no previous studies have examined the association of this polymorphism with inflammation. The present study assessed the association of the Val66Met polymorphism with serum levels of BDNF and inflammatory markers among depressed outpatients...
July 12, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28693408/erratum
#10
(no author information available yet)
No abstract text is available yet for this article.
July 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28649903/herbal-medicine-for-psychiatric-disorders-psychopharmacology-and-neuroscience-based-nomenclature
#11
Siu W Tang, Wayne H Tang, Brian E Leonard
OBJECTIVES: Herbs are frequently and concurrently used with prescribed drugs by patients worldwide. While clinical trials have found some herbs to be as useful as standard psychiatric drugs, most clinicians are unaware of their pharmacological mechanisms. METHODS: We searched English language and other language literature with English abstracts listed in PubMed website, supplemented by additional through Google Scholar's free academic paper abstract website for publications on herbs, focussing on their clinical use in mental disorders, their neurobiology and their pharmacology...
July 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28610451/cognitive-function-is-largely-intact-in-methadone-maintenance-treatment-patients
#12
Odelia Elkana, Miriam Adelson, Glen M Doniger, Anat Sason, Einat Peles
OBJECTIVES: To confirm our previous findings of less cognitive impairments (based on cognitive screening tools) among methadone maintenance treatment (MMT) patients who achieved take-home dose (THD) privileges. METHODS: a random sample of 65 Israeli MMT patients were studied using computerised, age and education standardised, cognitive domains (attention, executive function, memory, motor skills), and non-computerised phonetic and semantic verbal fluency. RESULTS: Cognitive scores were within ±1 standard deviation (SD) of average for most domains, including non-verbal IQ, attention and motor skills...
July 5, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28669319/serum-inflammatory-molecules-and-markers-of-neuronal-damage-in-alcohol-dependent-subjects-after-withdrawal
#13
Murielle Girard, Dominique Malauzat, Philippe Nubukpo
OBJECTIVES: Our aim is to describe changes in serum concentration for the proinflammatory factors TNF-α, IFN-gamma, IL-1beta, IL-8, IL-6, IL-10, IL-12, and MCP-1, for the satiety factor leptin and for factors associated with neuronal changes, neuron-specific enolase (NSE) and glial activation S100-beta protein (S100-β), and explore their association with abstinence in alcohol dependent subjects after withdrawal. METHODS: Serum sampling and clinical assessments from 115 alcohol-dependent subjects admitted to a psychiatric hospital for alcohol were repeated during the first 48 hours of withdrawal (M0) and 1, 2, 4 and 6 months (M1, M2, M4, M6) after...
July 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28669318/fronto-subcortical-functional-connectivity-in-patients-with-schizophrenia-and-bipolar-disorder-during-a-verbal-fluency-task
#14
Anaïs Vandevelde, Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: Impairments in language production are common of schizophrenia (SZ) and bipolar disorder (BD). Identifying distinct functional connectivity (FC) patterns in SZ and BD may provide biomarkers for their diagnoses. METHODS: 49 participants (15 SZ, 14 BD, and 20 HC) underwent a verbal fluency task consisting of mentally generating verbs in French, alternated with periods of silence. Functional network allowed identifying activation clusters: the medio-frontal cluster (MFC), the left subcortical cluster (LSCC) and the left fronto-lateral cluster (LFLC)...
July 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28660791/long-term-changes-of-salivary-exoglycosidases-and-their-applicability-as-chronic-alcohol-drinking-and-dependence-markers
#15
Napoleon Waszkiewicz, Ewa Maria Kratz, Sylwia Chojnowska, Anna Zalewska, Krzysztof Zwierz, Agata Szulc, Sławomir Dariusz Szajda, Anastasiya Nestsiarovich, Andrei Kapitau, Alina Kępka, Lucyna Ostrowska, Mirosława Ferens-Sieczkowska
OBJECTIVES: Investigation of long-term dynamic changes of salivary activity/output of exoglycosidases, deglycosylation processes and their applicability as alcohol markers. METHODS: Exoglycosidase (α-fucosidase (FUC), β-galactosidase (GAL), β-glucuronidase (GLU), β-hexosaminidase (HEX, HEX A and HEX B isoenzymes) and α-mannosidase (MAN)) activities were measured in the saliva of healthy social drinking controls (C), alcohol-dependent non-smokers (ANS) and alcohol-dependent smokers (AS) at the 1st, 15th, 30th and 50th day of abstinence after chronic alcohol drinking...
June 29, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28657472/evaluating-the-effects-of-exercise-on-cognitive-function-in-hypertensive-and-diabetic-patients-using-the-mental-test-and-training-system
#16
Robson Bonoto Teixeira, João Carlos Bouzas Marins, Paulo Roberto Santos Amorim, Israel Teoldo, Rocío Cupeiro, Marcelo Odilon Cabral de Andrade, Yuri de Lucas Xavier Martins, Pollyana de Rezende Castilho, Daniel Demétrio Magalhães, András Palotás, Luciana Moreira Lima
OBJECTIVES: Systemic arterial hypertension (SAH) and diabetes mellitus (DM) are important risk factors for developing cognitive impairment. General life-style changes including physical training are known to reduce elevated blood pressure and sugar levels, as well as improve mental health. The objective of this study was to evaluate whether supervised physical exercise enhances the cognitive status of patients with chronic diseases. METHODS: Volunteers with SAH, DM or SAH + DM participated in either aerobic or resistance training during a period of 12 weeks...
June 28, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28649941/treatment-effects-of-olanzapine-on-homotopic-connectivity-in-drug-free-schizophrenia-at-rest
#17
Wenbin Guo, Feng Liu, Jindong Chen, Renrong Wu, Lehua Li, Zhikun Zhang, Huafu Chen, Jingping Zhao
OBJECTIVES: Deficits in homotopic connectivity have been implicated in schizophrenia. However, alterations in homotopic connectivity associated with antipsychotic treatments in schizophrenia remain unclear due to lack of longitudinal studies. METHODS: Seventeen drug-free patients with recurrent schizophrenia and twenty-four healthy controls underwent resting-state functional magnetic resonance imaging scans. The patients were scanned at three time points (baseline, 6 weeks of treatment, and 6 months of treatment)...
June 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28649929/involvement-of-core-clock-genes-in-lithium-response
#18
Claudia Pisanu, Donatella Congiu, Carla Melis, Andrea Angius, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Alessio Squassina
No abstract text is available yet for this article.
June 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28532221/antiphospholipid-antibodies-are-associated-with-positive-screening-for-common-mental-disorders-in-women-with-previous-pregnancy-loss-the-noha-psy-observational-study
#19
Jean-Christophe Gris, Fabienne Cyprien, Sylvie Bouvier, Eva Cochery-Nouvellon, Géraldine Lavigne-Lissalde, Erick Mercier, Jean-Pierre Balducchi
OBJECTIVES: Case reports describe neuropsychiatric manifestations associated with antiphospholipid antibodies (aPlAbs). In patients sharing the same symptoms fulfilling the antiphospholipid syndrome (APS) clinical criteria, the prevalence of common mental disorders has, however, never been studied. METHODS: We observed women with three consecutive abortions before the 10th week of gestation or one foetal loss at or beyond the 10th week. We compared the prevalence of common psychiatric disorders detected through screening using the Mini International Neuropsychiatric Interview, 10 years after inclusion, in women with APS (n = 506), women negative for aPlAbs but carrying the F5rs6025 or F2rs1799963 thrombogenic polymorphism (n = 269), and women with negative thrombophilia screening results as controls (n = 764)...
June 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28511598/silexan-in-anxiety-disorders-clinical-data-and-pharmacological-background
#20
Siegfried Kasper, Walter E Müller, Hans-Peter Volz, Hans-Jürgen Möller, Egon Koch, Angelika Dienel
OBJECTIVES: Silexan is a lavender oil preparation available in 80-mg capsules. Here we review clinical trials investigating its anxiolytic efficacy, safety and tolerability in humans, as well as preclinical investigations supporting this therapeutic use. METHODS: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep...
June 19, 2017: World Journal of Biological Psychiatry
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