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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/29898625/branched-chain-amino-acids-are-associated-with-metabolic-parameters-in-bipolar-disorder
#1
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29893160/lithium-effects-on-serine-threonine-kinases-activity-high-throughput-kinomic-profiling-of-lymphoblastoid-cell-lines-from-excellent-responders-and-non-responders-bipolar-patients
#2
Jeverson Moreira, Gaëlle Noe, Savithri Rangarajan, Cindie Courtin, Bruno Etain, Pierre A Geoffroy, Jean-Louis Laplanche, Michel Vidal, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: Lithium (Li) is the leading mood stabilizer for maintenance treatment in bipolar disorder (BD). However, response to lithium is heterogeneous with more than 60% of patients experiencing partial or no response. In vitro and in vivo molecular studies have reported the implication of kinases in the pathophysiology of BD. METHODS: Since kinases are putative targets for lithium therapeutic action, we conducted the first pilot study using kinase array technology to evaluate the global serine/threonine kinases (STK) profiles in cell lines from BD I subtype patients classified as Li excellent-responders (ER) and non-responder (NR) to Li treatment...
June 12, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29869578/increased-cntf-levels-in-adults-with-autism-spectrum-disorders
#3
Natascia Brondino, Matteo Rocchetti, Laura Fusar-Poli, Stefano Damiani, Arianna Goggi, Giuseppe Chiodelli, Serafino Corti, Livia Visai, Pierluigi Politi
OBJECTIVES: Ciliary neurotrophic factor (CNTF) is a neurotrophin which could signal neuronal suffering and at the same time acts as a neuroprotective agent. In the present study we aimed to evaluate CNTF serum levels in Autism Spectrum Disorders (ASD). In fact, considering the role of CNTF as a neuronal damage signal and the role of neuroinflammation, excito-inhibitory imbalance and excitotoxicity in the pathogenesis of ASD, a possible alteration of CNTF in ASD could be hypothesised. METHODS: We recruited 23 individuals with ASD and intellectual disability (ID), 20 ID subjects and 26 typical adults...
June 5, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29843560/anhedonia-as-a-clinical-correlate-of-inflammation-in-adolescents-across-psychiatric-conditions
#4
Rachel D Freed, Lushna M Mehra, Daniel Laor, Manishkumar Patel, Carmen M Alonso, Seunghee Kim-Schulze, Vilma Gabbay
Objectives Peripheral inflammation has been associated with multiple psychiatric disorders, particularly with depression. However, findings remain inconsistent and unreproducible, most likely due to the disorder's heterogeneity in phenotypic presentation. Therefore, in the present study, in an effort to account for inter-individual differences in symptom severity, we utilised a dimensional approach to assess the relationships between a broad panel of inflammatory cytokines and key psychiatric symptoms (i.e...
May 30, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29683396/reduced-peripheral-availability-of-tryptophan-and-increased-activation-of-the-kynurenine-pathway-and-cortisol-correlate-with-major-depression-and-suicide
#5
Amel Messaoud, Rym Mensi, Wahiba Douki, Fadoua Neffati, Mohamed Fadhel Najjar, Gabriella Gobbi, Flavia Valtorta, Lotfi Gaha, Stefano Comai
OBJECTIVES: Patients affected by major depression (MDD) are at high risk of suicide. The metabolism of tryptophan (Trp) along the serotonin (5-HT) and kynurenine (Kyn) pathways was found dysfunctional in MDD and in suicide. However, a clear biological framework linking dysfunctions in Trp metabolism via 5-HT and Kyn, cortisol, and the activities of tryptophan and indoleamino 2,3-dioxygenase (TDO, IDO) enzymes has not been yet clarified in MDD with or without suicidal behaviours. METHODS: We analysed peripheral markers of Trp via 5-HT and Kyn pathways, Kyn/Trp ratio as a measure of TDO/IDO activities, cortisol, and psychopathology in 73 non-suicidal and 56 suicidal MDD patients, and in 40 healthy controls...
May 23, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29722600/improving-collaboration-between-primary-care-and-mental-health-services
#6
Nick Kates, Bruce Arroll, Elizabeth Currie, Charlotte Hanlon, Henrikje Klasen, Graham Meadows, Godfrey Rukundo, Nadia Sunderji, Torleif Ruud, Mark Williams
In almost any country - whether high, middle or low income - primary care providers play major roles in delivering mental health care. Indeed, the World Health Organization has recognized that in many low and middle-income countries, meeting the mental health needs of the population can only be achieved through greater integration of mental health services within primary care settings. Other guidelines and planning documents have reached similar conclusions and made suggestions as to how to achieve this. This position paper builds upon this work and synthesizes their ideas and recommendations into a framework for enhancing mental health care delivered within primary care settings...
May 3, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29611450/elevated-serum-vascular-endothelial-growth-factor-in-treatment-resistant-schizophrenia-treated-with-electroconvulsive-therapy-positive-association-with-therapeutic-effects
#7
Wenhuan Xiao, Qiongqiong Zhan, Fei Ye, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
OBJECTIVES: As the name implies, vascular endothelial growth factor (VEGF) enhances angiogenesis, promotes vascular permeability, and stimulates neurogenesis in the adult brain. Furthermore, animal model studies have shown that electroconvulsive therapy (ECT), which is primarily utilised in cases of treatment-resistant schizophrenia (TRS), regulates the expression of VEGF. The current study focuses largely on the effect of ECT on VEGF serum concentration, and the relationship between VEGF and therapeutic effects in patients diagnosed with TRS...
April 26, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29353534/no-detectable-effects-of-acute-tryptophan-depletion-on-short-term-immune-system-cytokine-levels-in-healthy-adults
#8
Caroline S Hildebrandt, Katrin Helmbold, Maike Linden, Karl-Josef Langen, C P Filss, Kevin C Runions, Richard M Stewart, Pradeep Rao, Julie K Moore, Simone Mahfouda, Hugo A E Morandini, Janice W Y Wong, Lothar Rink, Florian D Zepf
Recent research suggested an influence of diminished central nervous serotonin (5-HT) synthesis on the leptin axis via immunological mechanisms in healthy adult females. However, studies assessing immunological parameters in combination with dietary challenge techniques that impact brain 5-HT synthesis in humans are lacking.  Methods: In the present trial, a pilot analysis was conducted on data obtained in healthy adult humans receiving either different dietary acute tryptophan depletion (ATD) challenge or tryptophan (TRP)-balanced control conditions (BAL) to study the effects of reduced central nervous 5-HT synthesis on serum tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β) and IL-6 concentrations...
April 26, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29688142/editorial
#9
Siegfried Kasper
No abstract text is available yet for this article.
June 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29076399/cerebrospinal-fluid-and-blood-biomarkers-for-neurodegenerative-dementias-an-update-of-the-consensus-of-the-task-force-on-biological-markers-in-psychiatry-of-the-world-federation-of-societies-of-biological-psychiatry
#10
Piotr Lewczuk, Peter Riederer, Sid E O'Bryant, Marcel M Verbeek, Bruno Dubois, Pieter Jelle Visser, Kurt A Jellinger, Sebastiaan Engelborghs, Alfredo Ramirez, Lucilla Parnetti, Clifford R Jack, Charlotte E Teunissen, Harald Hampel, Alberto Lleó, Frank Jessen, Lidia Glodzik, Mony J de Leon, Anne M Fagan, José Luis Molinuevo, Willemijn J Jansen, Bengt Winblad, Leslie M Shaw, Ulf Andreasson, Markus Otto, Brit Mollenhauer, Jens Wiltfang, Martin R Turner, Inga Zerr, Ron Handels, Alexander G Thompson, Gunilla Johansson, Natalia Ermann, John Q Trojanowski, Ilker Karaca, Holger Wagner, Patrick Oeckl, Linda van Waalwijk van Doorn, Maria Bjerke, Dimitrios Kapogiannis, H Bea Kuiperij, Lucia Farotti, Yi Li, Brian A Gordon, Stéphane Epelbaum, Stephanie J B Vos, Catharina J M Klijn, William E Van Nostrand, Carolina Minguillon, Matthias Schmitz, Carla Gallo, Andrea Lopez Mato, Florence Thibaut, Simone Lista, Daniel Alcolea, Henrik Zetterberg, Kaj Blennow, Johannes Kornhuber
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised...
June 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29513115/editorial
#11
Siegfried Kasper
No abstract text is available yet for this article.
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29493375/tdm-in-psychiatry-and-neurology-a-comprehensive-summary-of-the-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology-update-2017-a-tool-for-clinicians-sup
#12
Georgios Schoretsanitis, Michael Paulzen, Stefan Unterecker, Markus Schwarz, Andreas Conca, Gerald Zernig, Gerhard Gründer, Ekkerhard Haen, Pierre Baumann, Niels Bergemann, Hans Willi Clement, Katharina Domschke, Gabriel Eckermann, Karin Egberts, Manfred Gerlach, Christine Greiner, Ursula Havemann-Reinecke, Gudrun Hefner, Renate Helmer, Ger Janssen, Eveline Jaquenoud-Sirot, Gerd Laux, Thomas Messer, Rainald Mössner, Matthias J Müller, Bruno Pfuhlmann, Peter Riederer, Alois Saria, Bernd Schoppek, Margarete Silva Gracia, Benedikt Stegmann, Werner Steimer, Julia C Stingl, Manfred Uhr, Sven Ulrich, Roland Waschgler, Gabriela Zurek, Christoph Hiemke
OBJECTIVES: Therapeutic drug monitoring (TDM) combines the quantification of drug concentrations in blood, pharmacological interpretation and treatment guidance. TDM introduces a precision medicine tool in times of increasing awareness of the need for personalized treatment. In neurology and psychiatry, TDM can guide pharmacotherapy for patient subgroups such as children, adolescents, pregnant women, elderly patients, patients with intellectual disabilities, patients with substance use disorders, individuals with pharmacokinetic peculiarities and forensic patients...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28299981/electroconvulsive-therapy-against-the-patients-will-a-case-series
#13
Isabel Methfessel, Alexander Sartorius, David Zilles
OBJECTIVES: Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive and psychotic disorders. As patients may be subject to legal incapacity and lack of insight, treatment may be administered against the patient's will. There is only limited evidence on the use of ECT against the patient's non-autonomous will. METHODS: We report a series of eight patients who received ECT against their will in two German university medical hospitals between 2014 and 2016...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28132573/reduced-astrocyte-density-underlying-brain-volume-reduction-in-activity-based-anorexia-rats
#14
Linda Frintrop, Johanna Liesbrock, Lisa Paulukat, Sonja Johann, Martien J Kas, Rene Tolba, Nicole Heussen, Joseph Neulen, Kerstin Konrad, Beate Herpertz-Dahlmann, Cordian Beyer, Jochen Seitz
OBJECTIVES: Severe grey and white matter volume reductions were found in patients with anorexia nervosa (AN) that were linked to neuropsychological deficits while their underlying pathophysiology remains unclear. For the first time, we analysed the cellular basis of brain volume changes in an animal model (activity-based anorexia, ABA). METHODS: Female rats had 24 h/day running wheel access and received reduced food intake until a 25% weight reduction was reached and maintained for 2 weeks...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28112047/venous-thromboembolism-during-treatment-with-antipsychotics-results-of-a-drug-surveillance-programme
#15
Martin Letmaier, Renate Grohmann, Christiana Kren, Sermin Toto, Stefan Bleich, Rolf Engel, Thomas Gary, Konstantinos Papageorgiou, Anastasios Konstantinidis, Anna Katharina Holl, Annamaria Painold, Siegfried Kasper
OBJECTIVES: Venous thromboembolism (VTE) can be a life-threatening medical condition that may lead to leg swelling, respiratory distress and death. METHODS: The AMSP (Arzneimittelsicherheit in der Psychiatrie) is a continuous multicentre drug surveillance programme that assesses severe adverse drug reactions during treatment of psychiatric inpatients. We report on a total of 264,422 inpatients who were treated with antipsychotics (APs) and monitored from 1993 to 2011 in 99 psychiatric hospitals...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27873550/self-and-other-body-perception-in-anorexia-nervosa-the-role-of-posterior-dmn-nodes
#16
Esther Via, Ximena Goldberg, Isabel Sánchez, Laura Forcano, Ben J Harrison, Christopher G Davey, Jesús Pujol, Ignacio Martínez-Zalacaín, Fernando Fernández-Aranda, Carles Soriano-Mas, Narcís Cardoner, José M Menchón
OBJECTIVES: Body image distortion is a core symptom of anorexia nervosa (AN), which involves alterations in self- (and other's) evaluative processes arising during body perception. At a neural level, self-related information is thought to rely on areas of the so-called default mode network (DMN), which, additionally, shows prominent synchronised activity at rest. METHODS: Twenty female patients with AN and 20 matched healthy controls were scanned using magnetic resonance imaging when: (a) viewing video clips of their own body and another's body; (b) at rest...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27427239/body-image-dissatisfaction-in-pregnant-and-non-pregnant-females-is-strongly-predicted-by-immune-activation-and-mucosa-derived-activation-of-the-tryptophan-catabolite-trycat-pathway
#17
Chutima Roomruangwong, Buranee Kanchanatawan, André F Carvalho, Sunee Sirivichayakul, Sebastien Duleu, Michel Geffard, Michael Maes
OBJECTIVES: The aim of the present study is to delineate the associations between body image dissatisfaction in pregnant women and immune-inflammatory biomarkers, i.e., C-reactive protein (CRP), zinc and IgA/IgM responses to tryptophan and tryptophan catabolites (TRYCATs). METHODS: We assessed 49 pregnant and 24 non-pregnant females and assessed Body Image Satisfaction (BIS) scores at the end of term (T1), and 2-4 days (T2) and 4-6 weeks (T3) after delivery. Subjects were divided in those with a lowered BIS score (≤ 3) versus those with a higher score...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27367046/high-throughput-dna-methylation-analysis-in-anorexia-nervosa-confirms-tnxb-hypermethylation
#18
Miriam Kesselmeier, Carolin Pütter, Anna-Lena Volckmar, Hansjörg Baurecht, Harald Grallert, Thomas Illig, Khadeeja Ismail, Miina Ollikainen, Yasmina Silén, Anna Keski-Rahkonen, Cynthia M Bulik, David A Collier, Eleftheria Zeggini, Johannes Hebebrand, André Scherag, Anke Hinney
OBJECTIVES: Patients with anorexia nervosa (AN) are ideally suited to identify differentially methylated genes in response to starvation. METHODS: We examined high-throughput DNA methylation derived from whole blood of 47 females with AN, 47 lean females without AN and 100 population-based females to compare AN with both controls. To account for different cell type compositions, we applied two reference-free methods (FastLMM-EWASher, RefFreeEWAS) and searched for consensus CpG sites identified by both methods...
April 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29521179/familial-abnormalities-of-endocannabinoid-signaling-in-schizophrenia
#19
Dagmar Koethe, Franziska Pahlisch, Martin Hellmich, Cathrin Rohleder, Juliane K Mueller, Andreas Meyer-Lindenberg, E Fuller Torrey, Daniele Piomelli, F Markus Leweke
OBJECTIVES: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states. METHODS: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from 25 twin pairs discordant for schizophrenia, six discordant for bipolar disorder and eight healthy twin pairs to determine hereditary traits...
March 22, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29457916/systematic-review-of-psychiatric-signs-in-niemann-pick-disease-type-c
#20
Olivier Bonnot, Hans-Hermann Klünemann, Christian Velten, Juan Vicente Torres Martin, Mark Walterfang
OBJECTIVES: We conducted the first systematic literature review and analysis of psychiatric manifestations in Niemann-Pick disease type C (NPC) to describe: (1) time of occurrence of psychiatric manifestations relative to other disease manifestations; and (2) frequent combinations of psychiatric, neurological and visceral disease manifestations. METHODS: A systematic EMBase literature search was conducted to identify, collate and analyze published data from patients with NPC associated with psychiatric symptoms, published between January 1967 and November 2015...
March 12, 2018: World Journal of Biological Psychiatry
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