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World Journal of Biological Psychiatry

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https://www.readbyqxmd.com/read/28105895/prefrontal-cortex-dysfunction-in-hypoxic-ischaemic-encephalopathy-contributes-to-executive-function-impairments-in-rats-potential-contribution-for-attention-deficit-hyperactivity-disorder
#1
Patrícia Maidana Miguel, Bruna Ferrary Deniz, Iohanna Deckmann, Heloísa Deola Confortim, Ramiro Diaz, Daniela Pereira Laureano, Patrícia Pelufo Silveira, Lenir Orlandi Pereira
OBJECTIVES: The attention-deficit/hyperactivity disorder (ADHD) compromises the quality of life of individuals including adaptation to the social environment. ADHD aetiology includes perinatal conditions such as hypoxic-ischaemic events; preclinical studies have demonstrated attentional deficits and impulsive-hyperactive outcomes after neonatal hypoxic and/or ischaemic intervention, but data are missing to understand this relationship. Thus, the aim of this study was to evaluate executive function (EF) and impulsivity, and tissue integrity and dopaminergic function in the prefrontal cortex (PFC) of rats submitted to hypoxia-ischaemia (HI)...
January 20, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28097908/common-and-specific-genes-and-peripheral-biomarkers-in-children-and-adults-with-attention-deficit-hyperactivity-disorder
#2
Cristian Bonvicini, Stephen V Faraone, Catia Scassellati
OBJECTIVES: Elucidating the biological mechanisms involved in Attention-deficit/hyperactivity disorder (ADHD) has been challenging. Relatively unexplored is the fact that these mechanisms can differ with age. METHODS: We present an overview on the major differences between children and adults with ADHD, describing several studies from genomics to metabolomics performed in ADHD children and in adults. A systematic search (up until February, 2016) was conducted. RESULTS: From a PRISMA flow-chart, a total of eligibility 350 studies from genomics and metabolomics were found for cADHD and 91 for aADHD...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28095742/lithium-response-in-bipolar-disorders-and-core-clock-genes-expression
#3
Pierre A Geoffroy, Emmanuel Curis, Cindie Courtin, Jeverson Moreira, Thomas Morvillers, Bruno Etain, Jean-Louis Laplanche, Frank Bellivier, Cynthia Marie-Claire
OBJECTIVES: We examine if the lithium response is associated with changes in core clock genes expressions. METHODS: The effect of a therapeutic concentration of lithium (1mM) on the expression levels of 17 circadian genes, was examined in lymphoblastoid cell lines (LCLs) derived from two well-characterized groups of BD patients, defined as lithium non-responders (NR, n = 20) or excellent responders (ER, n = 16). Quantitative real-time PCR (qRT-PCR) were conducted at 2, 4 and 8 days (d2, d4, d8) with and without lithium exposure...
January 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090807/neurocognitive-function-in-pediatric-obsessive-compulsive-disorder
#4
Daniel A Geller, Amitai Abramovitch, Andrew Mittelman, Abigail Stark, Kesley Ramsey, Allison Cooperman, Lee Baer, S Evelyn Stewart
OBJECTIVES: The small body of neuropsychological research in pediatric OCD yields inconsistent results. A recent meta-analysis found small effect sizes, concluding that pediatric OCD may not be associated with cognitive impairments, stressing the need for more research. We investigated neuropsychological performance in a large sample of OCD youth, while assessing potential moderators. METHODS: Participants with OCD (n = 102), and matched controls (n = 161) were thoroughly screened and blindly evaluated for comorbidities, and completed a neuropsychological battery assessing processing-speed, visuospatial abilities (VSA), working memory (WM), nonverbal memory (NVM), and executive functions (EF)...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090806/randomized-sham-controlled-study-of-high-frequency-bilateral-deep-transcranial-magnetic-stimulation-dtms-to-treat-adult-attention-hyperactive-disorder-adhd-negative-results
#5
Yaniv Paz, Keren Friedwald, Yeheal Levkovitz, Abraham Zangen, Uri Alyagon, Uri Nitzan, Aviv Segev, Hagai Maoz, May Koubi, Yuval Bloch
BACKGROUND: Recent studies support the possible effectiveness of rTMS as a treatment for ADHD. OBJECTIVES: To evaluate the safety and possible efficacy of bilateral prefrontal deep rTMS for the treatment of adult ADHD. METHODS: Twenty-six adult ADHD patients were randomized blindly to sham or actual deep TMS. Twenty daily sessions were conducted using the bilateral H5 deep TMS coil (Brainsway, IL) in order to stimulate the prefrontal cortex at 120% of the motor threshold at high frequency...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090804/choline-acetyltransferase-may-contribute-to-the-risk-of-tourette-syndrome-combination-of-family-based-analysis-and-case-control-study
#6
Xiuling Yang, Wenmiao Liu, Mingji Yi, Ru Zhang, Yinglei Xu, Zuzhou Huang, Shiguo Liu, Tang Li
OBJECTIVES: Twin and family analyses have revealed a genetic contribution to Tourette syndrome and postmortem studies have raised the intriguing possibility of a reduction in cholinergic interneuronsin TS patients. METHODS: We selected five tag SNPs (rs100824791, rs12264845, rs1880676, rs3793790 and rs3793798) of Choline Acetyltransferase (CHAT) from the Han Chinese population Hapmap database. Genotyping was conducted on 401 TS nuclear family trios and 405 control subjects...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28090803/insulin-like-growth-factor-binding-protein-2-in-bipolar-disorder-an-expression-study-in-peripheral-tissues
#7
Elena Milanesi, Roberta Zanardini, Gianluca Rosso, Giuseppe Maina, Alessandro Barbon, Cristina Mora, Alessandra Minelli, Massimo Gennarelli, Luisella Bocchio-Chiavetto
OBJECTIVES: Insulin-like Growth Factor Binding Protein 2 (IGFBP2) is a member of the family of high-affinity binding proteins (IGFBP1-6) and appears to play a governing role in Insulin-like Growth Factor (IGF) regulation in the central nervous system. This study aimed to investigate the putative involvement of IGFBP2 in mood disorder pathogenesis by measuring its expression levels in patient peripheral tissues. METHODS: IGFBP2 protein and mRNA levels were measured in the serum of 93 controls, 41 Bipolar Disorder (BD) and 43 Major Depressive Disorder (MDD) patients and in the skin fibroblasts from 15 controls, 12 BD and 23 MDD patients...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28010171/neural-correlates-of-prediction-violations-in-boys-with-tourette-syndrome-evidence-from-harmonic-expectancy
#8
Judith Buse, Christian Beste, Veit Roessner
OBJECTIVES: It has been suggested that Tourette syndrome (TS) might be associated with alterations of the attention system, but the nature of these alterations and the underlying neuroanatomical network remains elusive. We aimed at investigating the functional neuroanatomical modulators of attention allocation towards predictable vs. unpredictable stimuli in boys with TS. METHODS: Using fMRI, we ran a harmonic expectancy violation paradigm in 17 boys with TS and 23 matched healthy controls (HC)...
December 23, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28010158/abnormalities-of-language-pathways-in-schizophrenia-patients-with-and-without-a-lifetime-history-of-auditory-verbal-hallucinations-a-dti-based-tractography-study
#9
Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: Auditory verbal hallucinations (AVHs) are frequently observed in patients with schizophrenia and could be the result of white matter (WM) fibre abnormalities involved in speech production/comprehension and perception. We evaluated WM integrity changes in schizophrenia with (SZ+) and without (SZ-) lifetime AVHs compared to healthy controls, using diffusion tensor imaging-based tractography, with a novel focus on the structural connectivity within both intra- and interhemispheric fasciculi...
December 23, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28006997/guidelines-for-biological-treatment-of-substance-use-and-related-disorders-part-1-alcoholism-first-revision
#10
Michael Soyka, Henry R Kranzler, Victor Hesselbrock, Siegfried Kasper, Jochen Mutschler, Hans-Jürgen Möller
These practice guidelines for the biological treatment of alcohol use disorders are an update of the first edition, published in 2008, which was developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). For this 2016 revision, we performed a systematic review (MEDLINE/PUBMED database, Cochrane Library) of all available publications pertaining to the biological treatment of alcoholism and extracted data from national guidelines. The Task Force evaluated the identified literature with respect to the strength of evidence for the efficacy of each medication and subsequently categorised it into six levels of evidence (A-F) and five levels of recommendation (1-5)...
December 23, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27844503/attentional-capture-by-physically-salient-stimuli-in-the-gamma-frequency-is-associated-with-schizophrenia-symptoms
#11
Laura Kornmayer, Gregor Leicht, Christoph Mulert
OBJECTIVES: Aberrant salience mainly is attributed to excessive dopaminergic processing in the ventral striatum. Increased gamma power during sensory processing of physical salience has been shown to be associated with positive trait schizotypy. In the present study, this is assessed in patients with schizophrenia. METHODS: The early evoked visual gamma-band response (GBR) at 40 Hz was assessed for a schizophrenia patient group (N = 22) and a matched healthy control group (N = 22) applying EEG time-frequency analysis...
December 23, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28000543/allelic-variation-in-dopamine-d2-receptor-gene-is-associated-with-attentional-impulsiveness-on-the-barratt-impulsiveness-scale-bis-11
#12
Jasmine B Taylor, Tarrant D R Cummins, Allison M Fox, Beth P Johnson, Janette H Tong, Troy A W Visser, Ziarih Hawi, Mark A Bellgrove
OBJECTIVES: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy seven (N = 677) non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11)...
December 21, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28000540/telomere-length-in-psychiatric-disorders-is-it-more-than-an-ageing-marker
#13
Nancy Monroy-Jaramillo, Elena Dyukova, Consuelo Walss-Bass
Objectives Psychiatric and substance use disorders have been associated with premature biological ageing. Telomere length (TL), considered an ageing marker, has been analyzed in psychiatric disorders, and to a lesser extent in substance use disorders, with recent findings suggesting TL may be related to disease pathology. Methods We conducted a critical and non-systematic literature search of TL studies published up to June 2016 in psychiatric and substance use disorders, focusing on studies describing mechanisms, including studies linking telomere biology with genetic factors, stress, and mitochondrial alterations (104 studies selected)...
December 21, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28000517/anxiety-and-depression-are-associated-with-long-term-outcomes-of-hepatocellular-carcinoma-a-nationwide-study-of-a-taiwan-cohort
#14
King-Teh Lee, Jin-Jia Lin, Hon-Yi Shi
OBJECTIVE: A natural experimental design was coupled with propensity score matching to assess the risks of anxiety and depression and to assess the longitudinal effects of anxiety and depression on healthcare utilization and mortality in hepatocellular carcinoma (HCC) patients. METHODS: This nationwide population-based cohort study retrospectively analyzed 7,304 patients treated for HCC during 1996-2010. Generalized estimating equations were used to estimate differences-in-differences models for examining the effects of anxiety and depression disorders...
December 21, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27885918/increased-deficits-in-emotion-recognition-and-regulation-in-children-and-adolescents-with-exogenous-obesity
#15
Ipek Percinel, Burcu Ozbaran, Sezen Kose, Damla Goksen Simsek, Sukran Darcan
OBJECTIVES: In this study we aimed to evaluate emotion recognition and emotion regulation skills of children with exogenous obesity between the ages of 11 and 18 years and compare them with healthy controls. METHODS: The Schedule for Affective Disorders and Schizophrenia for School Aged Children was used for psychiatric evaluations. Emotion recognition skills were evaluated using Faces Test and Reading the Mind in the Eyes Test. The Difficulties in Emotions Regulation Scale was used for evaluating skills of emotion regulation...
December 21, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27973969/hyperactivity-and-impulsivity-in-adult-attention-deficit-hyperactivity-disorder-is-related-to-glutamatergic-dysfunction-in-the-anterior-cingulate-cortex
#16
Jochen Bauer, Anne Werner, Waldemar Kohl, Harald Kugel, Anna Shushakova, Anya Pedersen, Patricia Ohrmann
OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is closely linked to the dysregulation of dopaminergic and noradrenergic neurotransmission in the fronto-striatal neural network, including the anterior cingulate cortex (ACC) and the dorsolateral prefrontal cortex (DLPFC). Additionally, increasing evidence supports the involvement of the glutamatergic system in the pathophysiology of ADHD. Impulsivity, a core symptom in patients with ADHD, has been repeatedly associated with glutamatergic neurotransmission, and pharmacological treatment of ADHD has been shown to reduce glutamate levels in the prefrontal cortex...
December 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27855565/impact-of-histamine-receptors-h1-and-h3-polymorphisms-on-antipsychotic-induced-weight-gain
#17
Arun K Tiwari, Danning Zhang, Jennie G Pouget, Clement C Zai, Nabilah I Chowdhury, Eva J Brandl, Li Qin, Natalie Freeman, Jeffrey A Lieberman, Herbert Y Meltzer, James L Kennedy, Daniel J Müller
OBJECTIVES: A positive correlation between antipsychotic-induced weight gain (AIWG) and the antagonist effect of antipsychotic drugs at the histamine H1 receptor (HRH1) as well as the agonist effect at the histamine H3 receptor (HRH3) in the brain has been consistently demonstrated. We investigated the potential impact of single-nucleotide polymorphisms (SNPs) in HRH1 and HRH3 genes on AIWG. METHODS: We analysed 40 tagSNPs in HRH1 (n = 34) and HRH3 (n = 6) in schizophrenia/schizoaffective disorder patients (n = 193) primarily treated with clozapine or olanzapine for up to 14 weeks...
December 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27844618/repatriation-is-associated-with-isthmus-cingulate-cortex-reduction-in-community-dwelling-elderly
#18
Raffaella Calati, Jerome J Maller, Chantal Meslin, Jorge Lopez-Castroman, Karen Ritchie, Philippe Courtet, Sylvaine Artero
OBJECTIVES: The impact of stressful life events (SLEs) on brain anatomy is poorly understood, particularly its long-term neural consequences. We tested the hypothesis that a serious SLE (repatriation of French citizens living in Algeria in 1962) is associated with changes in brain regions previously implicated in psychopathology (hippocampus, amygdala, corpus callosum, prefrontal cortex, anterior, posterior and isthmus cingulate cortex (ICC)) in a large elderly population. METHODS: Structural magnetic resonance imaging was used to acquire anatomical scans from 82 subjects repatriated from Algeria and 339 subjects without this experience or any other trauma...
December 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27841086/svcam-1-sicam-1-tnf-%C3%AE-and-il-6-levels-in-bipolar-disorder-type-i-acute-longitudinal-and-therapeutic-implications
#19
Maja Pantović-Stefanović, Nataša Petronijević, Bojana Dunjić-Kostić, Milica Velimirović, Tatjana Nikolić, Vladimir Jurišić, Maja Lačković, Aleksandar Damjanović, Sanja Totić-Poznanović, Aleksandar A Jovanović, Maja Ivković
OBJECTIVES: To explore the serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular cell adhesion molecule-1 (sICAM-1), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with bipolar disorder (BD), with regard to acute episode characteristics, course of the disorder and treatment. METHODS: The study group consisted of 83 patients diagnosed with BD type I. The control group consisted of 73 healthy individuals, matched with the study group according to age, gender and body mass index...
December 14, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27762161/structural-brain-changes-in-first-episode-mania-with-and-without-psychosis-data-from-the-systematic-treatment-optimization-program-for-early-mania-stop-em
#20
Kamyar Keramatian, Taj Dhanoa, Alexander McGirr, Donna J Lang, William G Honer, Raymond W Lam, Lakshmi N Yatham
OBJECTIVES: The neurobiological underpinnings of bipolar I disorder are not yet understood. Previous structural neuroimaging studies of bipolar disorder have produced rather conflicting results. We hypothesise that clinical sub-phenotypes of bipolar I disorder defined by their psychotic symptoms, especially those with mood-incongruent psychotic features, may have more extensive structural brain abnormalities. METHODS: We investigated structural brain alterations in patients with first-episode mania (n = 55) with mood-congruent (n = 16) and mood-incongruent (n = 32) psychotic features, as well as those without psychotic symptoms (n = 7), relative to healthy subjects (n = 56)...
December 8, 2016: World Journal of Biological Psychiatry
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