Anurag Gupta, Natko Nuber, Christoph Esslinger, Mareike Wittenbrink, Martin Treder, Alexandro Landshammer, Takuro Noguchi, Marcus Kelly, Sacha Gnjatic, Erika Ritter, Lotta von Boehmer, Hiroyoshi Nishikawa, Hiroshi Shiku, Lloyd Old, Gerd Ritter, Alexander Knuth, Maries van den Broek
We investigated whether antibodies against intracellular tumor-associated antigens support tumor-specific immunity when administered together with a treatment that destroys the tumor. We propose that released antigens form immune complexes with the antibodies, which are then efficiently taken up by dendritic cells. We cloned the first human monoclonal antibodies against the Cancer/Testis (CT) antigen, NY-ESO-1. We tested whether the monoclonal anti-NY-ESO-1 antibody (12D7) facilitates cross-presentation of a NY-ESO-1-derived epitope by dendritic cells to human CD8+ T cells, and whether this results in the maturation of dendritic cells in vitro...
2013: Cancer Immunity