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Current Allergy and Asthma Reports

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https://www.readbyqxmd.com/read/30229317/prenatal-diet-and-the-development-of-childhood-allergic-diseases-food-for-thought
#1
REVIEW
Michele N Pham, Supinda Bunyavanich
PURPOSE OF REVIEW: The development of allergic disease is shaped by genetics and the environment, including diet. Many studies suggest a role for maternal diet during pregnancy. In this article, we discuss potential mechanisms by which specific nutrients, particular foods, and dietary patterns may influence allergic disease development and review studies examining the relationship between prenatal diet and the risk of childhood allergy. RECENT FINDINGS: The combination of in utero exposures and genetic predisposition may contribute to the development of allergic disease by altering immune and organ development...
September 18, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30220060/administering-a-telemedicine-program
#2
REVIEW
Luisa Taylor, Heidi Capling, Jay M Portnoy
PURPOSE OF REVIEW: The purpose of this review is to describe the process of administering a telemedicine program including reviewing telemedicine guidelines; discussing licensing, credentialing, and privileging of providers; outlining scheduling and recruitment of patients; and measuring outcomes of a telemedicine program. RECENT FINDINGS: Recent literature findings suggest that telemedicine in specialty clinics continues to grow at a rapid pace. Medical specialty programs should prepare to adopt a practice that includes telemedicine to better serve their patients and families who have expressed significant satisfaction with the delivery of healthcare in this manner...
September 15, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30206718/food-allergies-caused-by-allergenic-lipid-transfer-proteins-what-is-behind-the-geographic-restriction
#3
REVIEW
M J Rial, J Sastre
PURPOSE OF REVIEW: To critically examine evidence suggesting that food allergy induced by lipid transfer proteins (LTPs) follows a geographic pattern. RECENT FINDINGS: LTP syndrome remains most common in the Mediterranean basin, with a clear gradient seen in prevalence of LTP sensitization between northern and southern Europe. We hypothesize that high levels of birch pollen seem to protect against LTP allergy, as these higher levels correlate with a lower prevalence of LTP hypersensitivity...
September 11, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30171358/biologics-and-small-molecule-agents-in-allergic-and-immunologic-skin-diseases
#4
REVIEW
Bridget P Kaufman, Andrew F Alexis
PURPOSE OF REVIEW: Biologics and small molecules are key therapeutic options in the treatment of chronic immunologic and allergic skin conditions. By directly targeting innate and inflammatory responses within the skin, including pro-inflammatory cytokines and cellular signaling pathways, these new agents have the potential to counteract the inflammatory cascade responsible for various conditions, including psoriasis and atopic dermatitis. Over the past decade, groundbreaking research identifying key cytokines and receptors involved in the pathogenesis of these diseases has allowed for the development of highly efficacious biologics and small molecules that are associated with unprecedented rates of skin clearance and favorable adverse event profiles...
August 31, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30145709/telemedicine-a-primer
#5
REVIEW
Morgan Waller, Chad Stotler
PURPOSE OF REVIEW: Due to rapid advancements in quality of real-time, interactive, audio-visual, and digital technologies as well as impressive gains in internet speed and capacity, medicine delivered over distance is happening faster than many healthcare providers and leaders can grasp. RECENT FINDINGS: Depending on which market report you ascribe to, industry projections for the global compounded annual growth rate of telemedicine are between 13 and 27%, with valuation growing to over 20 billion US dollars in the next several years...
August 25, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30145683/a-review-of-portable-electronic-spirometers-implications-for-asthma-self-management
#6
REVIEW
Delesha M Carpenter, Reina Jurdi, Courtney A Roberts, Michelle Hernandez, Robert Horne, Amy Chan
PURPOSE OF REVIEW: Although portable electronic spirometers allow for at-home lung function monitoring, a comprehensive review of these devices has not yet been conducted. We conducted a systematic search and review of commercially available portable electronic spirometers designed for asthma patient use. RECENT FINDINGS: All devices (N = 16) allowed for monitoring of basic lung function parameters, but only 31% provided in-app videos on how to perform breathing maneuvers...
August 25, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30128784/bedroom-allergen-exposure-beyond-house-dust-mites
#7
REVIEW
Paivi M Salo, Richard D Cohn, Darryl C Zeldin
PURPOSE OF REVIEW: The review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest, and fungal exposures. RECENT FINDINGS: Large-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, have extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation of specific bacterial taxa...
August 20, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30112673/clinical-manifestation-of-hyper-ige-syndrome-including-otitis-media
#8
REVIEW
Jing Wu, Li Hong, Tong-Xin Chen
PURPOSE OF REVIEW: The hyper IgE syndromes (HIES) comprise a group of rare primary immunodeficiency disorders (PIDDs), which are characterized by extremely high serum IgE levels, eczema, recurrent skin and pulmonary infections. Both autosomal dominant (AD) HIES due to STAT3 mutations and autosomal recessive (AR) HIES due to PGM3, SPINK5, DOCK8 and TKY2 mutations have been reported. Here, we aim to summarize and compare the major clinical manifestations of different subtypes of HIES. We will also discuss otitis media, which usually do not get enough attention in HIES...
August 15, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30112587/tips-for-seeing-patients-via-telemedicine
#9
REVIEW
Jennifer Shih, Jay Portnoy
PURPOSE OF REVIEW: Telemedicine is a technology that permits patients to be seen at a distance. This review describes different types of telemedicine, why they might be useful for a practice, what equipment is needed, and how to select and schedule patients. RECENT FINDINGS: The use of synchronous telemedicine is increasing rapidly and has surpassed 50% of ambulatory encounters in some instances. Management of patients is particularly germane for an allergy practice since it is an outpatient specialty with patients who live in widely distributed locations with limited access to allergists...
August 15, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30069607/allergic-contact-dermatitis-evaluation-strategies-for-the-preschooler
#10
REVIEW
Calvin T Sung, Maria A McGowan, Sharon E Jacob
PURPOSE OF REVIEW: The environment for the developing children is complex as they are exposed to a variety of activities and settings where potential environmental allergens may be encountered. Recent evidence supports the clinical benefit of patch testing young children suffering from recalcitrant dermatitis. While patch testing has been recently approved by the Food and Drug Administration in children ages 6-18 years old, patch testing strategies for young children of preschool age (between 2 and 6 years old) have yet to be defined...
August 1, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/30046922/motile-ciliary-disorders-in-chronic-airway-inflammatory-diseases-critical-target-for-interventions
#11
REVIEW
Wei-Jie Guan, Yang Peng, Xiao-Xue Zi, Kai Sen Tan, Ting-Ting He, Nan-Shan Zhong, De Yun Wang
PURPOSE OF REVIEW: Impaired mucociliary clearance has been implicated in chronic upper and lower airway inflammatory diseases (i.e., allergic and non-allergic rhinitis, chronic rhinosinusitis with or without nasal polyps and asthma). How motile ciliary disorders (impaired ciliogenesis, ciliary beating and ultrastructural defects) are implicated in chronic airway inflammatory diseases is not fully understood. Elaboration of the role of motile ciliary disorders may serve as therapeutic targets for improving mucociliary clearance, thereby complementing contemporary disease management...
July 26, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29995271/endotypes-of-chronic-rhinosinusitis-across-ancestry-and-geographic-regions
#12
REVIEW
Wirach Chitsuthipakorn, Kachorn Seresirikachorn, Doron D Sommer, Tobial McHugh, Kornkiat Snidvongs
PURPOSE OF REVIEW: Preliminary studies have suggested differences in endotypes of chronic rhinosinusitis (CRS) across ancestry/ethnic groups. Eosinophilic CRS (ECRS) is the predominant subtype for Western/European ancestry CRS patients and non-eosinophilic CRS (nECRS) for Asian patients. This review aims to re-analyze CRS endotypes across ancestry populations using one consistent criteria to existing data. RECENT FINDINGS: Although tissue eosinophilia is the most commonly used criterion for ECRS, various cut-off points are suggested...
July 11, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29995257/is-allergen-immunotherapy-in-children-disease-modifying-a-review-of-the-evidence
#13
REVIEW
Amanda K Rudman Spergel, Michael Minnicozzi, Lisa M Wheatley, Alkis Togias
PURPOSE OF REVIEW: Although evidence supports a beneficial effect of allergen immunotherapy on the symptoms of allergic respiratory disease and food allergy, it is not clear whether immunotherapy modifies the natural history of these conditions. RECENT FINDINGS: In aeroallergen immunotherapy, studies suggest that prevention of asthma can be attained. Less evident is the ability of immunotherapy to prevent new allergen sensitizations and more studies are needed to test whether immunotherapy can continue suppressing airway symptoms after treatment discontinuation...
July 11, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29992472/prospects-for-monoclonal-antibody-therapy-in-pediatric-asthma
#14
REVIEW
August Generoso, Christine Muglia-Chopra, John Oppenheimer
PURPOSE OF REVIEW: The profile of biologic therapies for asthma is growing rapidly. We discuss how to match the proper pediatric patient with the most effective therapy. RECENT FINDINGS: Currently available biologic therapies are most effective in patients with T2 high asthma. Newer drugs are currently being studied which target TSLP and interleukin 33. These newer drugs may provide options for asthmatics who do not respond to the current anti-IgE, anti-IL5, and anti-IL4/13 therapies...
July 10, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29936646/the-child-with-recurrent-mycobacterial-disease
#15
REVIEW
Brian Reed, William K Dolen
PURPOSE OF REVIEW: Many genetic conditions predispose affected individuals to opportunistic infections. A number of immunodeficiency diseases, including genetic defects termed Mendelian susceptibility to mycobacterial disease (MSMD), permit infection from many different strains of mycobacteria that would otherwise not cause disease. These include tuberculous and nontuberculous mycobacteria, and bacille Calmette-Guérin vaccine (BCG). Patients may present with infections from other organisms that depend on macrophage function for containment...
June 23, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29909507/what-is-the-relationship-between-eosinophilic-esophagitis-eoe-and-aeroallergens-implications-for-allergen-immunotherapy
#16
REVIEW
Maureen Egan, Dan Atkins
PURPOSE OF REVIEW: Observations suggesting that aeroallergens trigger eosinophilic esophagitis (EoE) in a subset of patients raise questions about the implications this finding has on the evaluation and management of patients with EoE, including a potential role for allergen immunotherapy. RECENT FINDINGS: The majority of studies evaluating the potential role of aeroallergens as provocateurs of EoE have addressed this issue by assessing the seasonal variation in EoE diagnosis and/or symptom onset or worsening, with mixed results...
June 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29904888/olfactory-dysfunction-in-neurodegenerative-diseases
#17
REVIEW
Concepció Marin, Dolores Vilas, Cristóbal Langdon, Isam Alobid, Mauricio López-Chacón, Antje Haehner, Thomas Hummel, Joaquim Mullol
PURPOSE OF REVIEW: The sense of smell is today one of the focuses of interest in aging and neurodegenerative disease research. In several neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, the olfactory dysfunction is one of the initial symptoms appearing years before motor symptoms and cognitive decline, being considered a clinical marker of these diseases' early stages and a marker of disease progression and cognitive decline. Overall and under the umbrella of precision medicine, attention to olfactory function may help to improve chances of success for neuroprotective and disease-modifying therapeutic strategies...
June 15, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29904820/food-induced-anaphylaxis-an-update
#18
REVIEW
Christopher P Parrish, Heidi Kim
PURPOSE OF REVIEW: This review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA). RECENT FINDINGS: Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tests promise more accurate identification of food triggers. Oral, sublingual, and epicutaneous immunotherapy can desensitize a significant portion of subjects...
June 14, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29904803/atypical-cutaneous-presentations-of-sarcoidosis-two-case-reports-and-review-of-the-literature
#19
REVIEW
David L Leverenz, Christopher Henderson, Ankoor Shah
PURPOSE OF REVIEW: The goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin. RECENT FINDINGS: While the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised district with altered local immune trafficking and neural signaling...
June 14, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29886521/next-generation-of-allergen-specific-immunotherapies-molecular-approaches
#20
REVIEW
Mirela Curin, Musa Khaitov, Alexander Karaulov, Leyla Namazova-Baranova, Raffaela Campana, Victoria Garib, Rudolf Valenta
PURPOSE OF REVIEW: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. RECENT FINDINGS: AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources...
June 9, 2018: Current Allergy and Asthma Reports
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