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Transfusion and Apheresis Science

Guanyi Chen, Liguo Zhu, Shufang Wang, Yuan Zhuang, Yang Yu, Deqing Wang
BACKGROUND: The prepared procedure for universal plasma in the Chinese population has been developed. However, the immunological safety with the level of antibodies, soluble immune complexes and complements is necessary to investigate. METHODS: The universal plasma was pooled at the optimal ratio of A:B:AB = 6:2.5:1.5 at 22 °C for 1 hour. The titer of IgM antibodies was detected by saline agglutination, and the titer of IgG antibodies was detected by a Polybrene test after IgM destroyed by 2-mereaptoethanol...
November 14, 2016: Transfusion and Apheresis Science
Cécile Sénémeaud, Camille Sanrey, Nathalie Callé, Candice Plainfossé, Alexandra Belhaire, Patrice Georget
This study examined the effectiveness of exposure to a "watching-eyes image" in increasing blood donation rates among young people, a segment of the population that is particularly underrepresented among blood donors. Participants were 454 first-year university students, each of who was given a blood-donation flyer at the beginning of a lecture. Participants were randomly assigned to one of two conditions depending on whether the flyer they received bore a picture of eyes (experimental condition) or a neutral picture (control condition)...
November 14, 2016: Transfusion and Apheresis Science
Mohammad Hossein Mohammadi, Behnam Molavi, Saeed Mohammadi, Mohsen Nikbakht, Ashraf Malek Mohammadi, Shayan Mostafaei, Amir Hossein Norooznezhad, Ali Ghorbani Abdegah, Ardeshir Ghavamzadeh
The aim of the present study was to evaluate the effectiveness of using autologous platelet-rich plasma (PRP) gel for treatment of diabetic foot ulcer (DFU) during the first 4 weeks of the treatment. In this longitudinal and single-arm trial, 100 patients were randomly selected after meeting certain inclusion and exclusion criteria; of these 100 patients, 70 (70%) were enrolled in the trial. After the primary care actions such as wound debridement, the area of each wound was calculated and recorded. The PRP therapy (2 mL/cm(2) of ulcers) was performed weekly until the healing time for each patient...
November 2, 2016: Transfusion and Apheresis Science
Eva Meler, Roser Porta, Carme Canals, Bernat Serra, Miguel Lozano
The most frequently involved antigen in severe fetal and neonatal alloimmune thrombocytopenia (FNAIT) is the human platelet antigen 1a. Platelets express the HLA-A and B antigens on their membrane and some studies report that maternal anti-HLA class I antibody can also cause FNAIT. We report here a very unusual case of a first twin pregnancy produced in vitro by oocyte and semen donation where the mother developed markedly elevated HLA antibodies, in the absence of anti-platelet or anti-neutrophil antibodies, that provoked in one of the twins a profound thrombocytopenia and intracranial hemorrhage and a mild thrombocytopenia and neutropenia in the second twin lasting until the fourth month of life...
November 2, 2016: Transfusion and Apheresis Science
Harry R Dalton, Jerard Seghatchian
Following the discovery of HEV in the 1980s, it became apparent that HEV is endemic in a number of developing countries in Asia, Africa and Mexico. In these geographical settings HEV is spread oral faecally by HEV genotypes (gt) 1 and 2, which are obligate human pathogens. Infection occurs oro-faecally, often as a result in the breakdown of fragile sanitary infrastructure allowing drinking water supplies to become contaminated with human sewage. Hepatitis E usually causes a self-limiting hepatitis in young adults with sporadic cases and occasional dramatic outbreaks involving hundreds or thousands of cases...
November 1, 2016: Transfusion and Apheresis Science
Jerard Seghatchian
No abstract text is available yet for this article.
October 31, 2016: Transfusion and Apheresis Science
Jerard Seghatchian
No abstract text is available yet for this article.
October 31, 2016: Transfusion and Apheresis Science
Carlos H Villa, Jerard Seghatchian, Vladimir Muzykantov
Red blood cells (RBCs) are naturally capable of transporting diverse cargoes throughout the circulatory system, both loaded to their surface or within their inner volume. Starting largely from the 1970s, diverse approaches for encapsulation into, and surface coupling onto, RBCs have been investigated as potential drug delivery systems. In the last decade, these efforts have yielded diverse strategies to load drugs and nanocarriers to RBCs, and to optimize their pharmacokinetics, distribution, and effects in the body...
October 31, 2016: Transfusion and Apheresis Science
Dimas Tadeu Covas, Gail Rock
No abstract text is available yet for this article.
October 31, 2016: Transfusion and Apheresis Science
Aseem K Tiwari, Geet Aggarwal, Ravi C Dara, Dinesh Arora, Khushboo Srivastava, Vimarsh Raina
BACKGROUND: Blood donor experiences both immediate adverse reactions (IAR) and delayed adverse reactions (DAR). With limited published data available on the incidence of DAR, a study was conducted to estimate incidence and profile of DAR through telephonic interview. MATERIALS AND METHODS: Study was conducted over a 45-day period for consecutive volunteer whole blood donations at tertiary care hospital. Donors were divided into first-time, repeat and regular and were monitored for IAR...
October 29, 2016: Transfusion and Apheresis Science
Marianna H Antonelou, Jerard Seghatchian
Red blood cell storage lesion (RSL) is a multifaceted biological phenomenon. It refers to deterioration in RBC quality that is characterized by lethal and sub-lethal, reversible and irreversible defects. RSL is influenced by prestorage variables and it might be associated with variable clinical outcomes. Optimal biopreservation conditions are expected to offer maximum levels of RBC survival and acceptable functionality and bioreactivity in-bag and in vivo; consequently, full appraisal of RSL requires understanding of how RSL changes interact with each other and with the recipient...
October 29, 2016: Transfusion and Apheresis Science
Farheen Karim, Nadia Nasir, Bushra Moiz
Dengue virus can be transmitted via blood transfusion. We report an interesting case where two surgical patients developed possible transfusion transmitted dengue when transfused blood components of the same donor. Dengue remains a threat to blood supply especially in endemic region.
October 29, 2016: Transfusion and Apheresis Science
Ruqayyah J Almizraq, Jerard Seghatchian, Jason P Acker
There is an emerging interest in the risks posed by the ability of blood transfusion to modulate the immune system of recipients. Observational trials suggest that RBC transfusions may be associated with increased morbidity and mortality, however studies demonstrating the deleterious consequences of transfusion-related immunomodulation have had conflicting results. Efforts to understand the biological mechanisms responsible for TRIM are under way, and are focusing on the role that the extracellular vesicles (EVs) that accumulate in a red cell concentrate (RCC) during storage may play...
October 28, 2016: Transfusion and Apheresis Science
Seiji Mishima, Chikashi Matsuda, Tomoko Ishihara, Mayumi Nagase, Takeshi Taketani, Atsushi Nagai
We previously reported the association between LDL cholesterol level (LDL-C) and granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood (PB) hematopoietic stem cells (HSC). In this study, we investigated the association between gene single nucleotide polymorphisms (SNPs) involved in hematopoiesis and lipid level and PBHSC mobilization. In 46 patients who underwent peripheral blood stem cell harvest (PBSCH), we measured CD34-positive cells in PB and PBSCH, and the patients were classified into good, intermediate, or poor mobilizer groups based on the CD34-positive cell counts...
October 28, 2016: Transfusion and Apheresis Science
Yuzhong Yan, Jingjun Zhang, Qi Zhang, Yanping Chen, Xinfang Zhu, Rong Xia
Platelet storage lesions seriously affect the quality of stored platelets, even causing them to be ineffective in vivo after transfusion. Past research have been focused on what mechanism(s) cause the formation of storage lesions. One proposed mechanism is microRNAs (miRNAs)-based molecular regulation of the platelet mRNAs that are relevant to the storage lesion. Platelets continue to translate proteins from mRNA while in a storage environment. A strong correlation exists between the platelet transcriptome and its subsequent proteomic profile, which supports de novo platelet translational capabilities...
October 27, 2016: Transfusion and Apheresis Science
Eileen Galvin Karr
There are advantages to joining professional associations, especially in the field of apheresis. Members are exposed to many opportunities such as education, research, preparation for certification, networking, leadership and involvement in the association's annual meeting. This article provides insight into all of these subject topics.
October 25, 2016: Transfusion and Apheresis Science
Jaehyup Kim, Ranjit Joseph, Karen Matevosyan, Ravi Sarode
BACKGROUND: Spectra Optia (Terumo BCT, Lakewood, CO) was FDA approved for red blood cell exchange (RBCx) procedures in January 2014 and is expected to replace COBE spectra (Terumo BCT) very soon in the USA. The performance characteristics of these devices for Isovolemic Hemodilution (IHD-RBCx) procedure were compared in this study. METHODS: A total of 114 IHD-RBCx procedures from 19 patients were analyzed. For every patient, three procedures on each device with similar pre-procedure hematocrits were compared...
October 17, 2016: Transfusion and Apheresis Science
Shazia Nakhoda, Ann B Zimrin, Maria R Baer, Jennie Y Law
OBJECTIVES: Hypertriglyceridemic (HTG) pancreatitis carries significant morbidity and mortality and often requires intensive care unit (ICU) admission. Therapeutic plasma exchange (TPE) rapidly lowers serum triglyceride (TG) levels. However, evidence supporting TPE for HTG pancreatitis is lacking. METHODS: Ten patients admitted to the ICU for HTG pancreatitis underwent TPE at our institution from 2005-2015. We retrospectively calculated the Acute Physiology and Chronic Health Examination II (APACHE II) score at the time of initial TPE and again after the final TPE session to assess the impact of triglyceride apheresis on morbidity and mortality associated with HTG pancreatitis...
October 17, 2016: Transfusion and Apheresis Science
Manasa Reddy, Bernard Tawfik, Chakri Gavva, Sean Yates, Nicole De Simone, Sandra L Hofmann, Siayareh Rambally, Ravi Sarode
Thrombosis is known to occur in patients with rare inherited bleeding disorders, usually in the presence of a thrombotic risk factor such as surgery and/or factor replacement therapy, but sometimes spontaneously. We present the case of a 72-year-old African American male diagnosed with congenital factor VII (FVII) deficiency after presenting with ischemic stroke, presumably embolic, in the setting of atherosclerotic carotid artery stenosis. The patient had an international normalized ratio (INR) of 2.0 at presentation, with FVII activity of 6% and normal Extem clotting time in rotational thromboelastometry...
October 17, 2016: Transfusion and Apheresis Science
Garrett S Booth, Mary S Johnson
No abstract text is available yet for this article.
October 6, 2016: Transfusion and Apheresis Science
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