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Transfusion and Apheresis Science

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https://www.readbyqxmd.com/read/29292029/superior-integrin-activating-capacity-and-higher-adhesion-to-fibrinogen-matrix-in-buffy-coat-derived-platelet-concentrates-pcs-compared-to-prp-pcs
#1
Pezhman Beshkar, Ehteramolsadat Hosseini, Mehran Ghasemzadeh
BACKGROUND: Regardless of different sources, methods or devices which are applied for preparation of therapeutic platelets, these products are generally isolated from whole blood by the sedimentation techniques which are based on PRP or buffy coat (BC) separation. As a general fact, platelet preparation and storage are also associated with some deleterious changes that known as platelet storage lesion (PSL). Although these alternations in platelet functional activity are aggravated during storage, whether technical issues within preparation can affect integrin activation and platelet adhesion to fibrinogen were investigated in this study...
December 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29330014/frequency-of-red-blood-cell-genotypes-in-multi-transfused-patients-and-blood-donors-from-minas-gerais-southeast-brazil
#2
Vitor Mendonça Alves, Fernanda Bernadelli De Vito, Paulo Roberto Juliano Martins, Sheila Soares Silva, Lilian Castilho, Helio Moraes-Souza
BACKGROUND AND OBJECTIVES: The frequency of red blood cell (RBC) antigens in Brazil varies due to differences in the ethnic groups in different regions; however, these studies have not been performed in Minas Gerais, where African admixture is more prevalent in comparison with other states. Due to these facts, this study aimed to determine the frequency of RBC genotypes on Rh, Kell, Duffy and Kidd systems in blood donors and multi-transfused patients from Minas Gerais, Southeast Brazil...
December 16, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29310873/to-prevent-or-ameliorate-severe-plasmodium-falciparum-malaria-why-not-evaluate-the-impact-of-exchange-transfusions-of-sickle-cell-trait-red-blood-cells
#3
LETTER
Ryan P Jajosky, Audrey N Jajosky, Philip G Jajosky
No abstract text is available yet for this article.
December 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29289486/posterior-reversible-encephalopathy-syndrome-following-blood-transfusion-in-a-patient-with-factor-x-deficiency-is-it-an-unusual-systemic-manifestation-of-an-adverse-transfusion-reaction
#4
Anupam Verma, Hemlata, Priti Elhence, Shubha R Phadke, Zafar Neyaz
Adverse neurological transfusion reactions including posterior reversible encephalopathy syndrome (PRES) following blood transfusion are rare. Our case an 18-year-female with known Factor X deficiency with menorrhagia developed severe hypertension, followed by generalised tonic clonic convulsions apparently after blood component transfusion. She had earlier received 4 units of red blood cells (RBC) for anaemia and 10 units of fresh frozen plasma (FFP) for menorrhagia (with prolonged PT and APTT) within short span of time at another hospital...
December 6, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29269123/the-relationship-between-immunogenic-red-blood-cell-antigens-and-human-immunodeficiency-virus-infection
#5
Glenda M Davison, Heather L Hendrickse, Tandi E Matsha
INTRODUCTION: Evidence suggests that red cell antigens may act as receptors for viruses and bacteria and therefore could be associated with HIV infection. Previous studies have been controversial and therefore the aim of this exploratory study was to analyse the expression of immunogenic red cell antigens in HIV-seropositive individuals and to compare the results to negative donors from South Africa. METHODS: The expression of ABO, Rh, Kell and Duffy antigens from 119 HIV-seropositive patients was compared to 317 HIV-seronegative blood donors...
December 6, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29254749/effect-of-pre-donation-fluid-intake-on-fluid-shift-from-interstitial-to-intravascular-compartment-in-blood-donors
#6
Chenna Deepika, Mohandoss Murugesan, Shamee Shastry
BACKGROUND: Fluid shifts from interstitial to intravascular space during blood donation helps in compensating the lost blood volume. We aimed to determine the volume of fluid shift following donation in donors with and without pre-donation fluid intake. METHODS: We studied the fluid shift in 325 blood donors prospectively. Donors were divided in groups- with no fluid intake (GI) and either water (GII) or oral rehydrating fluids (GIII) before donation. Fluid shift following donation was calculated based on the difference between the pre and post donation blood volume...
December 5, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29196100/mathematical-calculation-of-lifespan-of-transfused-rbcs-in-sickle-cell-disease-patients
#7
Jaehyup Kim, Amena Usmani, Nicole De Simone, Ravi Sarode
BACKGROUND: Transfusion of donor red blood cells (RBCs) remains an important part of management of sickle cell disease (SCD). However, the survival characteristics of transfused donor RBCs in SCD patients have not been well studied. We sought to calculate survival kinetics of transfused RBCs in SCD patients since it is unclear whether transfused RBCs get destroyed at faster rate as innocent bystander or persist longer due to decreased destruction capacity such as functional splenectomy...
November 24, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29249628/an-analysis-of-blood-donation-barriers-experienced-by-north-american-and-caribbean-university-students-in-grenada-west-indies
#8
Benjamin W Dean, Sarah N Hewitt, Morgan C Begos, Angela Gomez, Locksley L McV Messam
OBJECTIVES: To estimate the associations of nationality, university program, donation history and gender, with blood donation barriers experienced by non-donating students on the day of a campus blood drive. This project focused particularly on nationality and the effect of the different blood donation cultures in the students' countries of origin. METHODS: A retrospective cohort study of 398 North American and Caribbean university students was conducted at St. George's University, Grenada, in 2010...
November 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162399/laboratory-assessment-of-activated-protein-c-resistance-factor-v-leiden-and-performance-characteristics-of-a-new-quantitative-assay
#9
REVIEW
Jean Amiral, Anne Marie Vissac, Jerard Seghatchian
Activated Protein C Resistance is mainly associated to a factor V mutation (RQ506), which induces a deficient inactivation of activated factor V by activated protein C, and is associated to an increased risk of venous and arterial thrombosis in affected individuals, caused by the prolonged activated factor V survival. Its prevalence is mainly in Caucasians (about 5%), and this mutation is absent in Africans and Asians. Presence of Factor V-Leiden is usually evidenced with clotting methods, using a two-step APTT assay performed without or with APC: prolongation of blood coagulation time is decreased if this factor is present...
November 14, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162395/automated-red-blood-cell-depletion-in-abo-incompatible-grafts-in-the-pediatric-setting
#10
REVIEW
Claudia Del Fante, Luigia Scudeller, Santina Recupero, Gianluca Viarengo, Stella Boghen, Antonella Gurrado, Marco Zecca, Jerard Seghatchian, Cesare Perotti
Bone marrow ABO incompatible transplantations require graft manipulation prior to infusion to avoid potentially lethal side effects. We analyzed the influence of pre-manipulation factors (temperature at arrival, transit time, time of storage at 4°C until processing and total time from collection to red blood cell depletion) on the graft quality of 21 red blood cell depletion procedures in ABO incompatible pediatric transplants. Bone marrow collections were processed using the Spectra Optia(®) (Terumo BCT) automated device...
November 14, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162398/hematopoietic-progenitor-cell-mobilization
#11
EDITORIAL
Fevzi Altuntaş, Serdal Korkmaz
No abstract text is available yet for this article.
November 11, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29158076/microcirculation-and-red-cell-transfusion-in-patients-with-sepsis
#12
REVIEW
Øystein Wendelbo, Tor Hervig, Oddbjørn Haugen, Jerard Seghatchian, Håkon Reikvam
Early identification of sepsis followed by diagnostic blood cultures and prompt administration of appropriate intravenous antibiotics covering all likely pathogen remains the corner stone in the initial management of sepsis. Source control, obtained by harvesting microbiological cultures and removal or drainage of the infected foci, is mandatory. However, optimization of hemodynamically unstable patients including volume support supplemented with vasopressor, inotropic and transfusion of red blood cells (RBCs) in case of persistent hypoperfusion have the potential to reduce morbidity and mortality...
November 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153307/new-insights-into-clinical-aspects-of-automated-rbc-depletion-in-pediatric-settings-sepsis-induced-rbc-defects-and-exploring-new-facets-of-factor-v-lieden-sampling-methods-to-the-spc-of-blood-component-production
#13
EDITORIAL
https://www.readbyqxmd.com/read/29153306/autologous-hematopoietic-progenitor-cell-mobilization-and-collection-in-adult-patients-presenting-with-multiple-myeloma-and-lymphoma-a-position-statement-from-the-turkish-society-of-apheresis-tsa
#14
REVIEW
Emre Tekgündüz, Mutlu Arat, Hakan Göker, Hakan Özdoğu, Leylagül Kaynar, Seçkin Çağırgan, Mehmet Ali Erkurt, Filiz Vural, İlhami Kiki, Fevzi Altuntaş, Fatih Demirkan
Autologous hematopoietic cell transplantation (AHCT) is a routinely used procedure in the treatment of adult patients presenting with multiple myeloma (MM), Hodgkin lymphoma (HL) and various subtypes of non-Hodgkin lymphoma (NHL) in upfront and relapsed/refractory settings. Successful hematopoietic progenitor cell mobilization (HPCM) and collection are the rate limiting first steps for application of AHCT. In 2015, almost 1700 AHCT procedures have been performed for MM, HL and NHL in Turkey. Although there are recently published consensus guidelines addressing critical issues regarding autologous HPCM, there is a tremendous heterogeneity in terms of mobilization strategies of transplant centers across the world...
November 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153349/world-apheresis-association-member-society-updates
#15
EDITORIAL
Jean O'Brien-Louis
No abstract text is available yet for this article.
November 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29153305/current-practice-of-autologous-hematopoietic-progenitor-cell-mobilization-in-adult-patients-with-multiple-myeloma-and-lymphoma-the-results-of-a-survey-from-turkish-hematology-research-and-education-group-threg
#16
REVIEW
Emre Tekgündüz, Fatih Demirkan, Filiz Vural, Hakan Göker, Hakan Özdoğu, İlhami Kiki, İsmet Aydoğdu, Leylagül Kaynar, Mehmet Ali Erkurt, Seçkin Çağırgan, Sevgi Beşışık, Simten Dağdaş, Ebru Koca, Gürhan Kadıköylü, Eren Gündüz, Mehmet Yılmaz, Hüseyin Beköz, Ali Uğur Ural, Abdülkadir Baştürk, Mutlu Arat, Murat Albayrak, Erman Öztürk, Alev Akyol, Ali Zahit Bolaman, Oral Nevruz, Hasan Atilla Özkan, Gökhan Özgür, Fevzi Altuntaş
Autologous hematopoietic cell transplantation (AHCT) is an established treatment option for adult patients presenting with multiple myeloma (MM), Hodgkin lymphoma (HL) and various subtypes of non-Hodgkin lymphoma (NHL) in upfront and/or relapsed/refractory disease settings. Although there are recently published consensus guidelines addressing critical issues regarding autologous hematopoietic progenitor cell mobilization (HPCM), mobilization strategies of transplant centers show high variability in terms of routine practice...
November 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29169683/leukapheresis-in-15-patients-weighing-20kg-or-less-a-single-centre-experience
#17
Feng Zeng, HaoBo Huang, DanHui Fu, QingHua Huang, LiPing Fan, ShiJing Wei
The application of apheresis equipment to perform leukapheresis (LK) in low weight paediatric patients is logistically complex and lacking of largest clinical performing experiences, meanwhile, the benefit from LK is controversial. In this study, 15 children with acute lymphoblastic leukemia(ALL)and acute myeloid leukemia (AML) and hyperleukocytosis were treated with the COBE Spectra apheresis system in the general paediatric ward by the staff from the department of Blood Transfusion. 26 LK procedures were performed...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162400/an-alternative-method-for-custom-prime-a-case-report-of-successful-peripheral-blood-stem-cell-harvesting-from-two-low-weight-child-donors
#18
Ashraf Malek Mohammadi, Amir Hossein Norooznezhad, Parivash Aminian, Mohsen Nikbakht, Bahram Chahardouli, Shahrbano Rostami, Farhad Heshmati, Saeed Mohammadi, Ardeshir Ghavamzadeh
Allogeneic peripheral blood stem cell (APBSCs) transplantation is an effective treatment for hematological malignancies. However low-weight donor children meet some complications. In the current report, PBSCs were harvested from a 14-month-old child (9.8Kg) for a 6years old sibling recipient suffering from pre-B type of acute lymphoblastic leukemia (ALL) and also 24 months old male child donor (12Kg) for a haploidentical recipient suffering from acute myeloid leukemia (AML-M4EO). The PBSC harvesting was performed using Spectra™ Optia(®) apheresis software with continuous mononuclear cell (CMNC) procedure...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162396/factors-associated-with-peripheral-blood-stem-cell-yield-in-healthy-pediatric-donors
#19
REVIEW
Gülsün Karasu, Vedat Uygun, Akif Yesilipek
BACKGROUND AND OBJECTIVES: Although several studies have reported on the use of children as donors for peripheral blood stem cells (PBSC), data on the predictive factors of CD34+ stem cell yield in healthy pediatric donors are very limited. DESIGN AND METHOD: We retrospectively analyzed factors predicting the yield for a target CD34 cell dose of >3×106/kg recipient body weight in 140 apheresis in 100 healthy pediatric donors. The donors were evaluated in four groups assigned according to their ages of being 0-4 years, 5-9 years, 10-14 years and 15-18 years...
November 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29162394/what-is-the-role-of-apheresis-technology-in-stem-cell-transplantation
#20
REVIEW
Ilhami Kiki
Since the demonstration that hematopoietic cells are present in circulating blood, peripheral blood stem cell transplantation (PBSCT) has become an area of interest. The invention of growth factors such as the granulocyte colony-stimulating factor (G-CSF) and the availability of apheresis techniques allowed the wide application of peripheral blood stem cells (PBSC) in both autologous and allogeneic hematopoietic stem cell transplantation settings. It has been since 1986 that clinically introduced, peripheral blood stem cells replaced bone marrow as a stem-cell source to nearly 100% in the autologous and to approximately 75% in the allogeneic transplantation setting...
November 8, 2017: Transfusion and Apheresis Science
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