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Transfusion and Apheresis Science

Jerard Seghatchian
No abstract text is available yet for this article.
October 31, 2018: Transfusion and Apheresis Science
Çiğdem Akalın Akkök, Jerard Seghatchian
It is a conceptual paradox to perform allogeneic hematopoietic stem cell transplantations across the ABO blood group border, when we, on the other hand, put so much effort into preventing ABO-incompatible transfusions. In clinical practice though it is still controversial whether ABO-incompatible allogeneic hematopoietic stem cell transplant have detrimental effects on patient outcomes in view of overall survival, non-relapse mortality, and graft-versus-host disease. However, the number of ABO-incompatible transplantations will probably continue to increase, unless solid evidence about contraindications can be presented...
October 30, 2018: Transfusion and Apheresis Science
Janie Charlebois, Georges-Étienne Rivard, Jean St-Louis
Acquired von Willebrand syndrome (AVWS) is a rare acquired bleeding disorder that resembles von Willebrand disease by its clinical symptoms and laboratory findings, but differs by its negative personal and family history of bleeding diathesis. AVWS is mostly seen in the elderly, but it has been described in children, often in those with congenital heart disease and Wilms tumor. It is most commonly associated with lymphoproliferative, myeloproliferative, cardio-vascular, or autoimmune diseases, solid tumors, and certain drugs...
October 30, 2018: Transfusion and Apheresis Science
Jean Amiral, Jerard Seghatchian
This manuscript aims to provide a concise review on current diagnostic/ confirmatory strategies of Heparin Induced Thrombocytopenia (HIT) with the combined use of immunological / functional assays in addition to the clinical probability. Laboratory diagnosis of HIT is of primordial importance as the related complications could become rapidly severe and life-threatening and can provoke limb amputation in some cases. The first action in the presence of HIT suspicion is to withdraw heparin and to initiate an alternative anticoagulant...
October 30, 2018: Transfusion and Apheresis Science
Janie Charlebois, Georges-Étienne Rivard, Jean St-Louis
Acquired hemophilia A (AHA) is a rare acquired bleeding disorder caused by autoantibodies against autologous factor VIII (FVIII). It is a disease that most commonly affects the elderly, but it has been described in children and during the post-partum period. It is idiopathic in 50% of cases and is associated with autoimmune disease, malignancy, pregnancy, infection or certain medications in the other 50%. The diagnosis should be suspected in patients with an isolated prolonged aPPT without previous personal or familial bleeding history...
October 30, 2018: Transfusion and Apheresis Science
Shilpa Jain, Suchitra S Acharya
Rare bleeding disorders (RBDs) comprise inherited deficiencies of factors I (fibrinogen), II (prothrombin), V, VII, X, XI, and XIII as well as combined factor V + VIII and vitamin K-dependent factors. They represent 3-5% of all congenital bleeding disorders and are usually transmitted as autosomal recessive traits. These disorders often manifest during childhood and have varied clinical presentations from mucocutaneous bleeding to life-threatening symptoms such as central nervous system and gastrointestinal bleeding...
October 30, 2018: Transfusion and Apheresis Science
Olivier Garraud
No abstract text is available yet for this article.
October 30, 2018: Transfusion and Apheresis Science
J M Stoffman, S Jackson, J Teitel
Treatment of hemophilia consists of replacement of the missing coagulation factor, either prophylactically or at the time of injury or bleeding. Because of the high cost of these products, which can present a barrier to care, different procurement strategies have been developed at national and regional levels. The emergence of novel therapeutic agents adds complexity to these strategies. This paper examines the benefits and challenges of these strategies, with primary reference to the Canadian context and a consideration of the concepts of value-based case...
October 30, 2018: Transfusion and Apheresis Science
Brianna Empringham, K Y Chiang, Joerg Krueger
Apheresis procedures are standard of care for a wide range of indications in children, collection of hematopoietic stem cells being the most frequent one. With increasing numbers of hematopoietic stem cell transplants, advances in graft manipulation techniques and the development of innovative therapies using immune effector cells and gene therapy, apheresis within the pediatric population is growing in demand. While young children have higher circulating white blood cell counts and robustly mobilize hematopoietic stem cells, apheresis machines were designed for use within the adult population and apheresis procedures in children, particularly small children, can be more challenging as vascular access, collection techniques and impact of extracorporeal volumes increase the rate of adverse events...
October 24, 2018: Transfusion and Apheresis Science
Utku Iltar, Ozan Salim, Alphan Küpesiz
No abstract text is available yet for this article.
October 6, 2018: Transfusion and Apheresis Science
Bonnie C Prokesch, Srikanth Nagalla, Fatemeh Ezzati, Shannan R Tujios, Arturo Dominguez, Weina Chen, Corey Kershaw, Prapti Patel, Carolina de la Flor, Jeannine Foster, Andrew A Martin, Maria Teresa de la Morena, Christian A Wysocki
PURPOSE: Hemophagocytic lymphohistiocytosis (HLH) in adults is rare but frequently fatal. Diagnosis is often delayed and treatment approaches vary significantly in contrast to the protocol-driven approach typically used in pediatric HLH. To improve care of these complex patients, this study retrospectively examined the prevalence, clinical characteristics, therapies and outcomes of adult HLH patients at two large tertiary care centers. METHODS: Adult patients with HLH confirmed by retrospective review of electronic medical records using HLH2004 criteria during admissions to the University of Texas Southwestern and Parkland Memorial Hospitals between June 2007 and June 2017 were studied...
October 6, 2018: Transfusion and Apheresis Science
Idoia Gimferrer, Gayle Teramura, Mary Gallagher, Paul Warner, Hongxiu Ji, Shilpi Chabra
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal alloimmune neutropenia (NAN) are two rare complications of newborns caused by antibodies against paternal inherited antigens. Human platelet (HPA) and neutrophil antigens (HNA) are the common targets. Human leukocyte antigen (HLA) class I proteins are also expressed on platelets and neutrophils and anti-HLA antibodies have occasionally been implicated in these complications. We report a premature twin infant who presented with severe thrombocytopenia and neutropenia clinically compatible with FNAIT and NAN, from a mother with no identifiable HPA or HNA antibodies, but with very high levels of complement-fixing antibodies against paternal inherited HLA...
September 29, 2018: Transfusion and Apheresis Science
William P Sheffield, Varsha Bhakta, Craig Jenkins
BACKGROUND: Plasma obtained via whole blood (WB) donation may be used either for transfusion or as recovered plasma (RP) for pooling and fractionation. In Canada, transfusable plasma must be processed within 24 h of phlebotomy, while the limit for RP processing is 72 h. We assessed the quality of RP produced by two WB processing methods and as a function of processing time. STUDY DESIGN AND METHODS: RP units produced via the buffy coat method (BCM, n = 26) or whole blood filtration (WBF, n = 52) were tested for: the activities of prothrombin, fibrinogen, von Willebrand Factor (VWF), FV, FVII, and FVIII; the prothrombin time (PT); and total protein and IgG concentration...
September 19, 2018: Transfusion and Apheresis Science
Paloma Del C Monroig-Bosque, Jonathan Balk, Francisco Segura, Eric Salazar, Christopher M Leveque, Tina S Ipe
Medication error is a preventable cause of morbidity and death in the inpatient population. We describe a patient with an antifungal overdose treated with therapeutic plasma exchange (TPE). The patient was diagnosed with cryptococcal meningitis and received an acute overdose of amphotericin B deoxycholate instead of the prescribed liposomal amphotericin B. Consequently, the patient developed clinical symptoms including tremors, hypertension, visual hallucinations, vertigo, fever, and acute renal failure. A series of four TPEs was emergently initiated, resulting in complete resolution of most symptoms...
September 18, 2018: Transfusion and Apheresis Science
Jin Jung, Jong-Mi Lee, Mina Yang, Seung Jun Choi, Jihyang Lim
Passenger lymphocyte syndrome (PLS) is a well-known cause of antibody mediated hemolysis after minor ABO mismatched transplantations. In most cases, PLS is mild and self-limited and easily recovered through transfusion. We report an unusual case of transient loss of A1 phenotype in AB blood type patient with PLS after ABO minor incompatible liver transplantation from B blood type deceased donor.
September 18, 2018: Transfusion and Apheresis Science
Akihiko Yokohama, Keiko Yokote, Takayuki Maruhashi
Peripheral blood stem cells (PBSCs) are currently one of the most important stem cell sources for hematopoietic stem cell transplantation as well as cell therapy for ischemic heart disease or critical limb ischemia. Thus, it is sometimes necessary to collect autologous PBSCs from donors who have comorbidities. In terms yield, a sufficient number of PBSCs can be collected from donors with comorbidities for performing cell therapy if their age is < 60 years or up to a maximum of 70 years, although the number of PBSCs collected from older donors would probably be lower than that obtained from younger donors...
September 18, 2018: Transfusion and Apheresis Science
Mustafa Serkan Durdu, Mehmet Cakici, Fatih Gumus, Gunseli Cubukcuoglu Deniz, Sinem Civriz Bozdag, Evren Ozcinar, Nur Dikmen Yaman, Osman Ilhan, Kemalettin Ucanok
OBJECTIVE: Apheresis is performed for treatment of numerous diseases by removing auto-antibodies, antigen-antibody complexes, allo-antibodies, paraproteins, non-Ig proteins, toxins, exogenous poisons. In current study, we present our experience of using therapeutic plasma exchange (TPE) in patients with different types of clinical scenarios. METHODS: Between January 2013 and May 2016, we retrospectively presented the results of 64 patients in whom postoperative TPE was performed in ICU setting after cardiac surgery...
September 18, 2018: Transfusion and Apheresis Science
Rafiye Ciftciler, Haluk Demiroglu, Yahya Buyukasık, Mufide Okay, Salih Aksu, Nilgun Sayınalp, Umit Yavuz Malkan, Ibrahim Celalettin Haznedaroglu, Osman Ozcebe, Hakan Goker
BACKGROUND AND AIM: This is a retrospective study aiming to investigate the effect of the number of high dose cytarabine-based chemotherapy (HiDAC) courses in patients with acute myeloid leukemia before allogenic stem cell transplantation (ASCT). MATERIALS AND METHODS: A total of 110 patients with acute myeloid leukemia who received ASCT between 2001 and 2018 were included in the study. RESULTS: Of the 110 patients, 25 (23%) patients received one course of HiDAC, 42 (38%) patients received two courses of HiDAC, 34 (31%) patients received three courses of HiDAC and 9 (8%) patients received four courses of HiDAC...
September 18, 2018: Transfusion and Apheresis Science
Miriam Stenzinger, Halvard Bonig
Leukapheresis is like any other preparative apheresis, except it isn't: Leukapheresis typically takes much longer, larger blood volumes are processed and, consequently, larger ACD-A volumes are administered. Blood component donors and leukapheresis subjects are also quite different populations. Allogeneic donors tend to be younger and many are first-time donors, both of which are risk factors for adverse reactions during blood donation. Moreover, more than half of all leukapheresis collections are performed in patients...
September 15, 2018: Transfusion and Apheresis Science
Olivier Garraud, Anneke Brand, Reinhard Henschler, Tomislav Vuk, Antoine Haddad, Miguel Lozano, Nigar Ertuğrul Örüç, Constantina Politis, Vincenzo de Angelis, Stefan Laspina, Jean-Daniel Tissot
A large body of observations indicate that there is an inconsistent knowledge of Transfusion Medicine among health care professionals as well as inconsistent knowledge in all aspects of the transfusion process, from blood donation to transfusion on the ward. It is obvious to consider that appropriate education in Transfusion Medicine should be achieved in the education of specialists who will prescribe transfusion on a regular basis (hematologists, critical care specialists, anaethesiologists and others.) However,we also believe that education in Transfusion Medicine should also be delivered to almost all other medical specialists who may prescribe blood components...
September 11, 2018: Transfusion and Apheresis Science
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