Read by QxMD icon Read

Transfusion and Apheresis Science

Kazuo Muroi
Transplants using peripheral blood hemopoietic stem/progenitor (PBHS) cells are widely performed for the treatment of patients with hematologic disorders in routine practice and clinical trials. Although the process from mobilization to infusion of PBHS cells has been mostly established, optimal conditions for each process remain undetermined. Adverse reactions caused by PBHS cell infusions have not been systematically recorded. In transplants using PBHS cells, a number of problems still exist. In this section, the current status of and future perspectives regarding PBHS cells are described...
September 11, 2018: Transfusion and Apheresis Science
Aicha Bah, Marcia Cardoso, Jerard Seghatchian, Raymond P Goodrich
Blood transfusion safety has been increasingly improving during the past two decades. However, threats from both known and emerging pathogens require continual improvement and re-assessment of blood safety measures. In this respect, we are currently witnessing the broader implementation of Pathogen reduction technology (PRT) for blood complements. These methods, combined with existing safety measures, have helped to reduce the pathogen risks of transfusion-transmitted infections. Currently multiple reviews have compared levels of inactivation between different commercialized PRTs...
September 11, 2018: Transfusion and Apheresis Science
Robert W Maitta
Apheresis is at the forefront of therapeutic approaches for an increasing number of indications caused by formation of pathologic antibodies treated by therapeutic plasma exchange, or through the use of red cell exchanges to overcome complications secondary to sickle cell crises. Likewise, the number of hematopoietic stem cell transplants has continued to grow annually and this is the direct result of the expansion of apheresis collections. Over the years a number of apheresis platforms have been utilized, but as one of the oldest and most widely used systems, the COBE Spectra, has ceased to be used therapeutically and at blood centers for donations there is an active search to find suitable systems that will replace it and have the versatility to perform as many procedures as possible...
September 11, 2018: Transfusion and Apheresis Science
Shin-Ichiro Fujiwara, Naohito Fujishima, Heiwa Kanamori, Masumi Ito, Tatsuya Sugimoto, Shoko Saito, Takeshi Sakaguchi, Koichi Nagai, Hidekazu Masuoka, Kazuhiro Nagai, Akie Morita, Shuichi Kino, Asashi Tanaka, Yuichi Hasegawa, Akihiko Yokohama, Keizo Fujino, Shigeyoshi Makino, Mayumi Matsumoto, Akihiro Takeshita, Kazuo Muroi
BACKGROUND: Plasma removal by washing is an effective approach to prevent transfusion reactions by platelet concentrates (PCs). Recently, washed PCs were released by the Japanese Red Cross Society (JRCS). MATERIALS AND METHODS: This retrospective multicenter study evaluated the efficacy and safety of released washed PCs (RWPCs) between September 2016 and January 2017 in Japan. The RWPCs were prepared by washing leukoreduced apheresis PCs with the platelet additive solution, BRS-A, using automated cell processors...
September 7, 2018: Transfusion and Apheresis Science
Avani Shah, Keyuri Jariwala, Snehalata Gupte, Preeti Sharma, Kanchan Mishra, Kanjaksha Ghosh
BACKGROUND: Extended phenotyping is one of the important method of reducing red cell alloimmunisation. Extended phenotyping of red cells from voluntary donors have many uses in addition to its application in population genetics. As there was very little data extended phenotyping on a cohort of Indian Voluntary blood donors this project was undertaken. STUDY DESIGN & METHODOLOGY: 200 regular voluntary blood donors having 'O' blood group were included for red cell antigen typing of Rh (D,C,E,c,e), Kell (K, k, Kpa , Kpb ), Duffy (Fya , Fyb ), Kidd (Jka , Jkb ), Lewis(Lea , Leb ), P(P1), MNS (M, N,S,s), and Lutheran (Lua , Lub ), Colton (Coa , Cob ), Diago (Diaa , Wra ), Vw and Xga antigens using conventional antisera provided by DIAGAST...
September 5, 2018: Transfusion and Apheresis Science
Mary-Frances Scully
No abstract text is available yet for this article.
August 23, 2018: Transfusion and Apheresis Science
Leonard A Valentino, Peter L Turecek, Herbert Gritsch, Saulius Butenas, Kenneth G Mann
We previously showed that personalizing prophylaxis on the basis of an individual's pharmacokinetic (PK) response to factor VIII (FVIII) infusion reduces joint and other bleeding events in patients with hemophilia A. We theorized that the FVIII assay used, FVIII product selected, and interpatient differences impact PK assessment and the ability to precisely dose prophylaxis. A comprehensive search of the literature for articles published from January 2004 to September 2017 was performed to identify the variables associated with these three domains...
August 20, 2018: Transfusion and Apheresis Science
Neşe Yaralı, Özlem Arman Bilir, Arzu Yazal Erdem, Vildan Çulha, Abdurrahman Kara, Namık Özbek
BACKGROUND AND AIM: Autoimmune hemolytic anemia (AIHA) is characterized by autoimmune destruction of erythrocytes. In this retrospective study, the clinical, laboratory features and treatment responses of patients with primary AIHA were evaluated. MATERIAL AND METHODS: 21 consecutive patients diagnosed with primary AIHA in a children's hospital from 2008 to 2016 were included. Clinical, laboratory findings and treatment responses were analyzed. RESULTS: Twenty-one patients, aged 6 months-15 years, with direct antiglobulin test positive anemia were presented...
August 8, 2018: Transfusion and Apheresis Science
Priscilla Cristina Moura Vieira, Letícia Martins Lamarão, Angelita Silva de Miranda Corrêa, Núbia Caroline Costa de Almeida, Renata Bezerra Hermes de Castro, Maurício Koury Palmeira, Rommel Rodríguez Burbano
No abstract text is available yet for this article.
August 8, 2018: Transfusion and Apheresis Science
Michela Tassara, Alessandro De Ponti, Lorena Barzizza, Matilde Zambelli, Cristina Parisi, Raffaella Milani, Luca Santoleri
INTRODUCTION: Autologous conditioned serum (ACS) is a novel blood product developed for intra-articular injection as a novel therapy for Osteoarthritis (OA). This study is a retrospective evaluation of 28 cases (25 Knee-OA and 3 hip-OA) treated with ACS between November 2013 and February 2016. MATERIALS AND METHODS: ACS was prepared according to standards in an accredited Cell Manipulation Lab, and applied by an expert clinician (2 ml injection once weekly over 4 weeks)...
August 8, 2018: Transfusion and Apheresis Science
Michael A Durda, Alisa S Wolberg, Bryce A Kerlin
Factor XIII, a heterotetrameric proenzyme, is converted to an activated transglutaminase by thrombin and calcium in the final phases of coagulation. Factor XIII catalyzes the formation of crosslinks between fibrin monomers and between α2-antiplasmin and fibrin. These crosslinks mechanically stabilize fibrin against shear stress, enable red cell retention within the clot, and protect the clot from premature degradation. Congenital factor XIII deficiency is caused by autosomal recessive mutations, presenting early in life with a severe bleeding diathesis...
August 4, 2018: Transfusion and Apheresis Science
Mariasanta Napolitano, Salvatrice Mancuso, Lucio Lo Coco, Piera Stefania Arfò, Simona Raso, Giovanni De Francisci, Francesco Dieli, Nadia Caccamo, Amalia Reina, Alberto Dolce, Rosalia Agliastro, Sergio Siragusa
Cryopreservation for the long-term storage of platelets (PLTs) is a useful method to overcome the limits of platelet shortage. This is an in vitro prospective study to evaluate the count, viability, and function of buffy coat-derived pooled platelet concentrates (BC-PLTs), treated with dimethyl sulphoxide (DMSO) and cryopreserved (CRY BC-PLTs) at -80 °C with a modified Valeri method. PLTs were stored in 6% DMSO with a patented kit. Overall, 49 BC-PLTs from 245 healthy volunteer donors were prepared, cryopreserved, and analysed before and after 3, 6, and 9 months of storage...
August 1, 2018: Transfusion and Apheresis Science
K Muroi
No abstract text is available yet for this article.
August 1, 2018: Transfusion and Apheresis Science
Federico Bigazzi, Francesco Sbrana, Daniele Berretti, Zenti Maria Grazia, Sabina Zambon, Antonia Fabris, Maurizio Fonda, Giovanni B Vigna, Giovanna D'Alessandri, Stefano Passalacqua, Beatrice Dal Pino, Mascia Pianelli, Roberta Luciani, Andrea Ripoli, Daniela Rafanelli, Enzo Manzato, Luigi Cattin, Tiziana Sampietro
BACKGROUND: Lipoprotein apheresis (LA) is the elective therapy for homozygous and other forms of Familial Hypercholesterolemia, Familial Combined Hypercholesterolemia, resistant/intolerant to lipid lowering drugs, and hyper-lipoproteinemia(a). Lipoprotein(a) [Lp(a)] has been classified as the most prevalent genetic risk factor for coronary artery disease and aortic valve stenosis. AIM: Our multicenter retrospective study has the aim to analyze the incidence of adverse cardiovascular events (ACVE) before and during the LA treatment, in subjects with elevated level of Lp(a) (>60 mg/dL) [hyper-Lp(a)] and chronic ischemic heart disease...
August 1, 2018: Transfusion and Apheresis Science
Gaurav Raturi, Paramjit Kaur, Gagandeep Kaur
OBJECTIVES: The present study was aimed to find out the prevalence of parvovirus B19  amongst healthy blood donors and blood transfusion recipients so as to determine the feasibility of providing seronegative blood components to vulnerable recipients. METHODS: A total of 1000 samples were studied which included 800 blood donors and 200 transfusion recipients.The transfusion recipients included 100 multitransfused patients and 100 non transfused controls.All samples were subjected to parvovirus B19 ELISA for IgG and IgM antibodies...
August 1, 2018: Transfusion and Apheresis Science
Egarit Noulsri, Attakorn Palasuwan
BACKGROUND: A number of factors cause increases in the number of cell-derived microparticles (MPs) in blood components. However, the overall effects of these factors on the concentration of MPs during routine blood-component preparation have not fully been elucidated. AIM: To evaluate the effects of donor age, donor sex, blood-component preparation, and storage on MP concentrations. METHODS: Flow cytometry was used to quantitate the number of whole blood-derived MPs...
August 1, 2018: Transfusion and Apheresis Science
Oytip Nathalang, Roanne Marion Ang, Benjamaporn Kurin, Siralak Limprasert, Supattra Mitundee, Nipapan Leetrakool, Kamphon Intharanut
BACKGROUND: S and s antigens of the MNS system are of clinical importance because alloanti-S and -s have usually caused delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. Various red cell genotyping has been established to predict the phenotypes to solve serological test limitations. OBJECTIVES AND METHODS: This study aimed to determine S and s genotype frequencies and to estimate the alloimmunization risks among central, northern and southern Thai populations...
August 1, 2018: Transfusion and Apheresis Science
Yoshiaki Furuta, Yuki Nakamura, Miho Tokida, Kayoko Ichikawa, Toshiya Ohsawa, Mitsuo Ohkubo, Akimichi Ohsaka
OBJECTIVE: The objective of this study was to determine the rate of adverse reactions to pre-operative autologous blood donation (PAD) transfusion in a single institution over a 14-year period. STUDY DESIGN AND METHODS: Between January 2003 and December 2016, we investigated adverse reactions to PAD transfusion and compared them with those to allogeneic blood transfusion in Juntendo University Hospital. Adverse reactions were categorized according to the definition proposed by the International Society of Blood Transfusion (ISBT) Working Party on Haemovigilance...
August 1, 2018: Transfusion and Apheresis Science
Barry Kevane, Niamh O'Connell
While recent advances in recombinant DNA technology, gene therapy and the discovery of novel non-substitutional agents have revolutionised the management of haemophilia A, plasma-derived clotting factor concentrates continue to be used and are likely to remain an important therapeutic option for the foreseeable future. The administration of plasma-derived products is associated with a risk of pathogen transmission. However, this risk has been greatly reduced, if not virtually eliminated, by modern manufacturing techniques...
July 29, 2018: Transfusion and Apheresis Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"