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Transfusion and Apheresis Science

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https://www.readbyqxmd.com/read/28428031/the-effect-of-hypoxia-preconditioning-on-the-neural-and-stemness-genes-expression-profiling-in-human-umbilical-cord-blood-mesenchymal-stem-cells
#1
Maryam Kheirandish, Somaie Piri Gavgani, Shahram Samiee
In recent years, human umbilical cord blood-derived mesenchymal stem cell (hUB-MSCs) has been regarded as an alternative source for stem cell therapy. In this study, we evaluated the effect of hypoxia preconditioning (HPC) on the expression of Nt-3, GFAP, Nestin, Oct-4 and Nanog genes and proliferative capacity of hUB-MSCs in comparison with normoxic conditions. HPC+Hypoxia protocol includes cultured hUB-MSCs for 15min at 2.5% O2 and after that reoxygenation for 30min at 21% O2 (HPC), and then hypoxia preconditioned hUB-MSCs subjected to 2...
March 31, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28392149/considerations-in-pediatrics
#2
EDITORIAL
Gail Rock
No abstract text is available yet for this article.
March 24, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28392150/factual-reflections-and-recommendations-on-extracorporeal-photopheresis-in-pediatrics
#3
REVIEW
Irena Sniecinski, Jerard Seghatchian
One of the biggest challenges in evaluating available literature on extracorporeal photopheresis (ECP) practices in pediatric patients is the marked heterogeneity of approaches to the patient evaluation, procedural aspects and apheresis product analysis. These issues are most relevant in ECP management in children with graft versus host disease (GVHD) after hematopoietic stem cell transplantation. Extracorporeal photopheresis in pediatric patients is considered relatively safe with few adverse effects reported from retrospective or observational studies...
March 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28372930/apheresis-education-one-center-curriculum-design-experience
#4
REVIEW
Rosaleen Nemec
There is little published in regards to apheresis education and curriculum for nursing. As more importance is placed on education, competency and skills for apheresis through accreditation processes, institutions are left to determine the educational requirements needed for nursing. Working with limited resources, one center has designed a comprehensive apheresis curriculum program that encompasses skills and theory for the novice to experienced learner. Utilizing existing hospital education and incorporating it into the apheresis curriculum was designed to meet the needs of the patient population, nurses and hospital...
March 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28389206/residual-risk-of-hiv-hcv-and-hbv-in-canada
#5
Sheila F O'Brien, Qi-Long Yi, Wenli Fan, Vito Scalia, Mindy Goldman, Margaret A Fearon
BACKGROUND: Residual risk is estimated as the product of the incidence and the infectious window period, the time during which a blood donation could be infectious but the assay may not detect it. In 2011 nucleic acid multiplex testing (MPX) was implemented in 6 unit minipools (previously 24 unit minipools). MPX also included hepatitis B (HBV) NAT for the first time (complementing HBsAg screening) in addition to HIV-1 and hepatitis C (HCV) as before. We aimed to estimate window period risk-day equivalents for MPX, and the residual risk of viral infections in blood donations updated to reflect current incidence and testing...
March 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28366590/increasing-use-of-therapeutic-apheresis-as-a-liver-saving-modality
#6
Hyun-Ji Lee, Kyung-Hwa Shin, Duyeal Song, Sun-Min Lee, Chulhun L Chang, Chong Woo Chu, Je Ho Ryu, Tae Bum Lee, Yong-Mok Park, Kwang Ho Yang, Byung Hyun Choi, Hyung-Hoi Kim
INTRODUCTION: Therapeutic plasma exchange (TPE) is used for temporary support of liver function in patients presenting with early graft dysfunction after liver transplantation (LT) or liver surgery. We analyzed the effect of therapeutic apheresis on patients with liver disease. METHODS: Between January 2011 and August 2016, 93 apheresis procedures were performed for 26 patients at our institution. Anti-ABO isoagglutination immunoglobulin (Ig) M titer was checked using a type A and type B 3% red blood cell (RBC) suspension in saline with two-fold serial dilutions of patient serum...
March 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343935/blood-derived-products-in-pediatrics-new-laboratory-tools-for-optimizing-potency-assignment-and-reducing-side-effects
#7
REVIEW
Jean Amiral, Jerard Seghatchian
Neonates and children can develop rare bleeding disorders due to congenital/acquired coagulation Factor deficiencies, or allo-immune/autoimmune complications, or can undergo surgeries at high haemorrhagic risk. They then need specialized transfusion of blood components/products, or purified blood extracted products or recombinant proteins. Blood-derived therapies conventionally used for management of affected infants with genetic/acquired deficiencies, bleeding problems (coagulation Factor reduced or missing) or thrombotic disorders (reduced or missing anticoagulant proteins) pose some additional risks...
March 15, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28347649/the-effect-of-intraarticular-serum-rich-in-growth-factors-srgf-on-knee-osteoarthritis-in-the-rat-model
#8
Shahrzad Azizi, Reza Kheirandish, Alireza Farsinejad, Najmeh Rasouli
Osteoarthritis (OA) is a degenerative joint disease with high incidence in world. Various treatments have been used for decreasing pain and improving physical function without clearly beneficial evidences. Nowadays, platelet-rich therapy is used as a novel approach in field of regenerative medicine. The present study evaluated the effect of intraarticular serum rich in growth factors (SRGF) on the monosodium iodoacetate induced-osteoarthritis in rat model. SRGF was injected 3 times weekly. Femorotibial joints were examined 2 weeks after last injection...
March 12, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28428030/complement-inhibition-with-eculizumab-for-thrombotic-microangiopathy-rescues-a-living-donor-kidney-transplant-in-a-patient-with-antiphospholipid-antibody-syndrome
#9
Praveen Ramakrishnan Geethakumari, Patrick Mille, Rakesh Gulati, Srikanth Nagalla
Antiphospholipid antibody syndrome (APS) is an enigmatic heterogeneous disorder despite several revelations in its pathobiology. Renal transplantation in patients with APS has been notoriously difficult due to the high risk of development of thrombotic microangiopathy (TMA), which is often refractory to conventional treatment modalities such as aggressive anticoagulation and plasmapheresis. We describe a case of a 58-year-old male with secondary APS undergoing living unrelated renal transplantation for end-stage renal disease from lupus nephritis...
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28363590/evolving-concepts-of-the-rbc-storage-lesion-using-omics-and-other-novel-diagnostic-tools
#10
REVIEW
Jerard Seghatchian
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28359603/balance-of-the-unsuccessful-systematization-of-measurement-uncertainty-in-medical-laboratories
#11
LETTER
Paulo Pereira, Jerard Seghatchian
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28347648/sarode-honoured-by-american-society-of-hematology
#12
EDITORIAL
G Rock, Ravi Sarode
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343936/hemolysis-in-six-week-old-autologous-red-blood-cell-components-questioned-worth-addressing-the-issue-of-homologous-components-as-well
#13
REVIEW
Olivier Garraud
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28363591/extracellular-vesicle-characteristics-in-stored-red-blood-cell-concentrates-are-influenced-by-the-method-of-detection
#14
REVIEW
Ruqayyah J Almizraq, Jerard Seghatchian, Jelena L Holovati, Jason P Acker
Extracellular vesicles (EVs), including microvesicles and exosomes, are small phospholipid vesicles (≤1μm in diameter) that are present in blood products, accumulate during storage, and have a potential transfusion-related immunomodulatory role. Knowledge of EVs in stored blood products is limited due to the challenges and difficulties in detecting these heterogeneous submicron-sized vesicles. The aim of this study was to assess the impact of different approaches to characterize EVs in stored RBC products...
March 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343934/hitchhiker-s-guide-to-the-red-cell-storage-galaxy-omics-technologies-and-the-quality-issue
#15
REVIEW
Angelo D'Alessandro, Jerard Seghatchian
Red blood cell storage in the blood bank makes millions of units of available for transfusion to civilian and military recipients every year. From glass bottles to plastic bags, from anticoagulants to complex additives, from whole blood to leukocyte filtered packed red blood cells: huge strides have been made in the field of blood component processing and storage in the blood bank during the last century. Still, refrigerated preservation of packed red blood cells under blood bank conditions results in the progressive accumulation of a wide series of biochemical and morphological changes to the stored erythrocytes, collectively referred to as the storage lesion(s)...
March 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343937/co-infection-of-blood-borne-viruses-in-blood-donors-a-cross-sectional-study-from-north-india
#16
Ravi C Dara, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Ganesh Singh Rawat, Jyoti Sharma, Devi Prasad Acharya, Gunjan Bhardwaj
BACKGROUND: There are several studies on prevalence of individual infectious disease markers (mono-infection) in donors but none on prevalence of coinfection. Co-infection is significant as it leads to accelerated disease progression. We, therefore, evaluated the prevalence of co-infection among blood donors. MATERIALS AND METHODS: The cross-sectional analysis was conducted in blood donors. All donors were tested for anti-HIV I and II, HBsAg, anti-HBC IgM, anti-HCV, Malaria and syphilis by chemiluminescence and ID-NAT assay...
March 6, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28342642/performance-comparison-of-new-generation-hcv-core-antigen-test-versus-hcv-rna-test-in-management-of-hepatitis-c-virus-infection
#17
Salih Çetiner, Alev Çetin Duran, Filiz Kibar, Akgün Yaman
The study has evaluated the performance of HCV core antigen (Cag) test by comparing HCV RNA PCR assay which is considered the gold standard for management of HCV infection. Totally, 132 samples sent for HCV RNA (real-time PCR) test were included in the study. Anti-HCV antibody test and HCV Cag test were performed by chemiluminescent enzyme immunoassay (CMEI). Anti-HCV test was positive in all samples. HCV RNA was detected in 112/132 (84.8%) samples, and HCV Cag in 105/132 (79.5%). The most common HCV genotype was genotype 1 (86%)...
March 6, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28319015/collection-storage-inspection-and-quality-control-of-platelet-concentrates-obtained-by-apheresis-the-situation-in-spain
#18
Azucena Castrillo, Teresa Jimenez-Marco, José L Arroyo, María L Jurado, Luis Larrea, Rosa M Maymo, Jorge Monge, Carmen Muñoz, Ángel Pajares, Marta Yáñez
BACKGROUND: Diverse variables are involved in apheresis platelet collection, processing and storage. This survey shows how these are realized in Spain. METHOD: An analysis of collected data was performed in a questionnaire completed by ten Transfusion Centers (TC) which perform between 50 and 520 apheresis procedures per month. This information comprises the procedures used to collect, inspect and store apheresis platelet concentrates (PC), and quality control data...
February 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28259531/plasmapheresis-in-severe-methemoglobinemia-following-occupational-exposure
#19
Wassim Shatila, Amanda Verma, Soheir Adam
Ferrous iron can be converted to ferric iron by oxidative stress which results in the formation of methemoglobin. Consequently, the oxygen dissociation curve is shifted to the left, which leads to tissue hypoxia and ultimately may cause death. Acquired methemoglobinemia can be due to a host of offending agents and chemicals including nitrites, local anesthetics, aniline and antimalarial drugs. There are several approaches to the management of methemoglobinemia. The first step is to stop the offending agent and initiate supportive measures...
February 20, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28359604/extra-corporeal-photochemotherapy-in-steroid-refractory-graft-versus-host-disease-a-review-of-guidelines-and-recommendations
#20
REVIEW
Saeed Mohammadi, Ashraf Malek Mohammadi, Amir Hossein Norooznezhad, Farhad Heshmati, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Regardless of remarkable progresses in prevention and treatment approaches, graft versus host disease (GVHD) remains a major impediment for successful allogeneic hematopoietic stem cells transplantation (HSCT) and leads to morbidity and mortality in transplanted patients. Corticosteroids are the standard therapy for GVHD; however, a great number of patients will not respond sufficiently and others will be significantly affected by adverse effects of steroids. Extracorporeal photochemotherapy (ECP), as one of the numerous second line therapies, through modulation of immune cells may improves GVHD affected organ function in steroid-refractory forms...
February 16, 2017: Transfusion and Apheresis Science
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