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Transfusion and Apheresis Science

Abeer Mohamed Abdelrazik, Hanan Elsayed Abozaid, Karim Abdelfattah Montasser
OBJECTIVE: The aim of the present study was to evaluate the efficacy of hepatitis C virus [HCV] core Ag as an alternative affordable test in resource limited countries blood banks. BACKGROUND: Implementing nucleic acid testing in developing countries with low resources is still unaffordable. Egypt has the highest prevalence of hepatitis C in the world and still in need to efficient affordable transfusion program that reduces the window period for the virus before implementing the complex high cost NAT...
June 30, 2018: Transfusion and Apheresis Science
Jerard Seghatchian
No abstract text is available yet for this article.
June 26, 2018: Transfusion and Apheresis Science
Farhad Heshmati
This manuscript highlights a new ANSM (French security agency for food & drug) approved method of ECP in order to render ECP easier and more secure for children and adults, with shorter time of procedure and lower final volume of cells (100 ml) and lower injected 8-MOP. This modified procedure is appropriately called "a Low Volume ECP (LV-ECP)".
June 16, 2018: Transfusion and Apheresis Science
Munira Borhany, Naveena Fatima, Madiha Abid, Tahir Shamsi, Maha Othman
BACKGROUND: Hemophilia is an inherited bleeding disorder. With proper treatment and self-care, persons with hemophilia can maintain an active, productive lifestyle. Hemophilia can be mild, moderate, or severe, depending on the degree of plasma clotting factor deficiency. The aim of the study was to assess the utility of ISTH-BAT in diagnosis, determining severity of the bleeding condition in newly diagnosed and known hemophilia patients, compare the bleeding score (BS) in adult and pediatric groups and investigate its association with plasma factor levels...
June 15, 2018: Transfusion and Apheresis Science
M Buzzi, P Versura, B Grigolo, C Cavallo, A Terzi, M Pellegrini, G Giannaccare, V Randi, E C Campos
INTRODUCTION: Various blood-derived products have been proposed for the topical treatment of ocular surface diseases. The aim of the study was to compare the different content of Growth Factors (GFs) and Interleukins (ILs) in peripheral blood (PB-S) and Cord Blood (CB-S) sera. MATERIALS AND METHODS: Sera were obtained from 105 healthy adult donors (PB-S) and 107 umbilical/placental veins at the time of delivery (CB-S). The levels of epithelial-GF (EGF), fibroblast-GF (FGF), platelet-derived-GF (PDGF), insulin-GF (IGF), transforming-GF alpha (TGF-α,) and beta 1-2-3 (TGF-β1-β2-β3), vascular endothelial-GF (VEGF), nerve-GF (NGF), Interleukin (IL)-1β,IL-4,IL-6,IL-10, and IL-13 were assessed by Bio-Plex Protein Array System (Bio-Rad Laboratories, CA, USA)...
June 13, 2018: Transfusion and Apheresis Science
Elias Kyriakou, Nikolaos Nearchakos, Stefanos Bonovas, Efstathia Makri, Katerina Pantavou, Georgios K Nikolopoulos, Christine Kottaridi, Argyri Gialeraki, Panagiota Douramani, Maria Taichert, Violetta Kapsimali, Argirios E Tsantes
BACKGROUND: Flow cytometry (FC) and Nageotte hemocytometry represent the most widely accepted methods for counting residual white blood cells (rWBCs) in leucocyte-reduced (LR) blood components. Our aim was to study the agreement between the two methods, under real working blood bank conditions. MATERIALS AND METHODS: 94 freshly produced LR red blood cell (RBC) units were tested for rWBC concentrations by FC and Nageotte. To assess the precision of each method, we calculated the intra-assay coefficients of variation (CV), and followed the Bland-Altman methodology to study the agreement between the two methods...
June 7, 2018: Transfusion and Apheresis Science
Karthik Nath, Rachael Boles, Andrew McCutchan, Venkat Vangaveti, Andrew Birchley, Ian Irving
A retrospective, observational study was performed of 112 patients who underwent autologous haematopoietic stem cell transplantation (ASCT) to determine the relationship between CD34+ stem cell dose and neutrophil engraftment. Importantly, a novel approach to more accurately calculate time to neutrophil engraftment was employed. The results demonstrated that a higher CD34+ stem cell dose was associated with faster neutrophil recovery (P < 0.05). CD34+ stem cell dose using actual and ideal patient body weight were both equally predictive of neutrophil engraftment as were absolute and viable CD34+ measurements...
June 6, 2018: Transfusion and Apheresis Science
Vassilis L Tzounakas, Serena I Valsami, Anastasios G Kriebardis, Issidora S Papassideri, Jerard Seghatchian, Marianna H Antonelou
Notwithstanding the high safety level of the currently available blood for transfusion and the decreasing frequency of transfusion-related complications, administration of labile blood products to paediatric patients still poses unique challenges and considerations. The incidence of thalassaemia and sickle cell disease in the paediatric population may be high enough under specific racial and geographical contexts. Red cell transfusion is the cornerstone of β-thalassaemia treatment and one of the most effective ways to prevent or correct specific acute and chronic complications of sickle cell disease...
June 4, 2018: Transfusion and Apheresis Science
Ya-Lien Cheng, Chih-Hsiang Chang, Wei-Ting Chen, Ming-Hung Tsai, Wei-Chen Lee, Kun-Hua Tu, Ya-Chung Tian, Yung-Chang Chen, Cheng-Chieh Hung, Ji-Tseng Fang, Chih-Wei Yang, Ming-Yang Chang
Patients with acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) have a high risk of mortality. Few studies have reported prognostic factors for patients receiving plasma exchange (PE) for liver support. We conducted a retrospective analysis using data of 55 patients with severe ACLF (n = 45) and ALF (n = 10) who received standard-volume PE (1-1.5 plasma volume) in the ICU. Hepatitis B virus infection accounts for the majority of ACLF (87%) and ALF (50%) patients. PE significantly improved the levels of total bilirubin, prothrombin time and liver enzymes (P<0...
June 2, 2018: Transfusion and Apheresis Science
Rafael Bielza, Asunción Mora, Francisco Zambrana, Jorge Sanjurjo, David Sanz-Rosa, Israel J Thuissard, Estefanía Arias, Marta Neira, Jorge Francisco Gómez Cerezo
BACKGROUND: Patient blood management (PBM) performs multidisciplinary strategies to optimize red blood cell (RBC) transfusion. Orthogeriatric share care models (surgeon and geriatrician manage the patient together from admission) have the goal of improving outcomes in hip fracture patients. MATERIAL AND METHODS: A prospective observational study was conducted. Patients aged ≥70 years undergoing hip fracture (HF) surgery were consecutively included. When admitted on the orthogeriatric service a PBM protocol was applied based on: perioperative antithrombotic management, intravenous iron sucrose administration and restrictive transfusion criteria...
May 30, 2018: Transfusion and Apheresis Science
Minh-Ha Tran, Haik Mkhikian, Michael Sy, Ingrid Perez-Alvarez, Michael Demetriou
Hashimoto's encephalopathy (HE) is a presumed autoimmune disorder associated with anti-thyroid autoantibodies and signs and symptoms of encephalopathy. A sub-type of HE is associated with cerebellar dysfunction and ataxia. Immunosuppressive therapy, particularly corticosteroid treatment, is utilized in the majority of cases. Short-term apheresis has been reported with variable patient responses. Here we report the case of a 72 year-old female with an ∼15 year history of cerebellar type HE that had profound improvement in symptoms after long-term apheresis treatment over an ∼2 year period...
May 29, 2018: Transfusion and Apheresis Science
Shion Imoto, Mari Kono, Takashi Suzuki, Yukiko Shibuya, Tohru Sawamura, Yuji Mizokoshi, Hirohide Sawada, Ayako Ohbuchi, Katsuyasu Saigo
BACKGROUND: Iron overload is a major issue for transfusion-dependent patients. Repeated transfusions result in the loading of large amounts of haem-derived iron on macrophages, and the haemin in turn induces cell death and the generation of reactive oxygen species (ROS) in both murine macrophages and human monocytic THP-1 cells. This haemin-induced cell death process has been shown to be iron-dependent. Thus, we hypothesized that haemin-induced THP-1 cell death is a result of ferroptosis, an iron-dependent mechanism of cell death regulation...
May 29, 2018: Transfusion and Apheresis Science
Irena Sniecinski
No abstract text is available yet for this article.
May 24, 2018: Transfusion and Apheresis Science
James D Burner, Dennis Goldfinger
No abstract text is available yet for this article.
May 19, 2018: Transfusion and Apheresis Science
Ivo Beverina, Patrizia Macellaro, Luciana Parola, Bruno Brando
Iron-deficiency anemia is a frequent condition in women and adolescent girls often caused by heavy menstrual bleeding. Sometimes the level of chronic anemia, although well tolerated, can be very severe. The recently introduced Patient Blood Management guidelines and the availability of effective and safe intravenous iron preparations may question transfusion as the traditional option. We describe here the case of a 13 years old girl with extreme iron-deficiency chronic anemia (Hb 33 g/L) that was successfully treated with i...
May 19, 2018: Transfusion and Apheresis Science
Cesare Perotti, Jerard Seghatchian, Claudia Del Fante
Urgency and emergency in general, and even more in the pediatric setting, remain a thematic debate not yet fully resolved. The decision to undergo a pediatric patient to an invasive treatment not free from potentially serious side effects like an apheresis procedure should be weighted with great attention. At the moment there is no unanimous consensus about the clinical pictures in which an urgency procedure in pediatrics is indicated. Each center acts according to its own experience and not infrequently to its own fears...
May 18, 2018: Transfusion and Apheresis Science
Fevzi Altuntas
No abstract text is available yet for this article.
May 18, 2018: Transfusion and Apheresis Science
Jean Amiral, Jerard Seghatchian
On demand and prophylaxis usage of FVIII/ FIX concentrates for the therapeutic management of hemophilia has greatly changed quality of life, and healthy life span of affected patients. Availability of recombinant therapeutic FVIII and FIX products, and of their long-acting variants, further improves the treatment constraints, and progressively permits to hemophiliacs to have an almost normal way of life. Unlimited amounts of recombinant or engineered substitutive products become available, and open new avenues for extending the benefits of prophylaxis to all hemophiliac patients, not only in economically advanced territories, but also in emerging and developing countries, worldwide...
May 16, 2018: Transfusion and Apheresis Science
Jacek Wachowiak, Alicja Chybicka, Jerzy R Kowalczyk, Mariusz Wysocki, Jolanta Goździk, Ewa Gorczyńska, Krzysztof Kałwak, Jan Styczyński, Katarzyna Drabko, Anna Pieczonka
The purpose of the survey was to evaluate the development and current use of hematopoietic stem cell transplantation (HSCT) in Poland between 1989-2016. The data for analysis (indication, number of performed HSCT, HSCT type, donor type, and stem cell source, year) have been collected annually using a standardized form. In Poland, between 1989-2016, the number of pediatric transplant beds grew from one to 40 and number and rate of transplants increased annually from 1/year (0.8/10 million) to 186/year (248/10 million)...
May 16, 2018: Transfusion and Apheresis Science
Çiğdem Akalın Akkök, Jerard Seghatchian
The aim of pediatric transfusions should be based on the concept of avoiding unnecessary transfusions without jeopardizing the patient safety and providing correct blood components when there are well founded indications to transfuse. Despite considerable efforts from transfusion services to increase transfusion safety, transfusions are still associated with preventable and unpreventable adverse effects that may, in the worst case, have severe and fatal consequences. Transfusions to pediatric patients constitute a small proportion of all transfusions but have higher incidence of adverse events compared to adults...
May 16, 2018: Transfusion and Apheresis Science
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