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Transfusion and Apheresis Science

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https://www.readbyqxmd.com/read/28512017/a-case-of-autoimmune-severe-acquired-von-willebrand-syndrome-type-3-like
#1
Chakri Gavva, Prapti Patel, Yu-Min Shen, Eugene Frenkel, Ravi Sarode
Von Willebrand disease (VWD) is the most common congenital bleeding disorder and is due to quantitative or qualitative defects of von Willebrand factor (VWF). Acquired defects of VWF, termed acquired von Willebrand syndrome (AVWS), are due to a host of different mechanisms. Autoantibody-mediated AVWS may be associated with lymphoproliferative or immunological disorders, such as systemic lupus erythematosus (SLE). A large majority of AVWS cases are type 1 or type 2A-like and patients tend to have a mild to moderate bleeding tendency...
April 27, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28515024/knowledge-attitude-and-practice-towards-blood-donation-among-health-care-providers-in-hospitals-at-bahir-dar-city-ethiopia
#2
Bayeh Abera, Beyan Mohammed, Wendmagegn Betela, Reshid Yimam, Adam Oljira, Merhab Ahmed, Wubet Tsega, Wondemagegn Mulu, Endalew Yizengaw
Like other sub-Saharan Africa, in Ethiopia there is a shortage of adequate and safe blood supplies. Health care providers are potential resource and promoter of voluntary blood donation. This study was conducted to determine the knowledge, attitude and practice towards blood donation among health care providers in Bahir Dar City, Ethiopia. Paper based questionnaire was distributed to 276 health care providers from May 01 to June 30, 2016. Overall, 42.8% had donated blood at least once. Of these, males accounted for 60%...
April 26, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28454884/immunoglobulin-g-levels-during-collection-of-large-volume-plasma-for-fractionation
#3
Thomas Burkhardt, Remo Rothe, Rainer Moog
BACKGROUND: There is a need of comprehensive work dealing with the quality of plasma for fractionation with respect to the IgG content as today most plasma derivates are used to treat patients with immunodeficiencies and autoimmune disorders. Therefore, a prospective study was carried out to analyse IgG levels before plasmapheresis and every 200ml collected plasma. MATERIALS AND METHODS: Fifty-four experienced plasmapheresis donors were recruited for subsequent 850ml plasmapheresis using the Aurora Plasmapheresis System...
April 12, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28454883/treatment-of-inflammatory-bowel-disease-by-leukocytapheresis
#4
Emre Gerçeker, Hakan Yüceyar, Elmas Kasap, Ufuk Demirci, Burcu Ceren Ekti, İsmet Aydoğdu, Mine Miskioğlu
Studies about leukocytapheresis have emerged with the need of search for alternatives to conventional treatment in inflammatory bowel diseases (IBD). Leukocytapheresis is a novel non-pharmacologic approach for active ulcerative colitis (UC) and Crohn's disease (CD), in which leukocytes are mechanically removed from the circulatory system. Patients with active IBD treated with leukocytapheresis using a Cellsorba E column between 2012 and 2015, were enrolled in Turkey. In our experience, the results of leukocytapheresis therapy in 6 patients with CD and 20 patients with active UC were overviewed...
April 12, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28438419/importance-of-extended-blood-group-genotyping-in-multiply-transfused-patients
#5
Nadila Haryani Osman, Jameela Sathar, Chooi Fun Leong, Noor Fadzilah Zulkifli, Raja Zahratul Azma Raja Sabudin, Ainoon Othman, Asral Wirda Ahmad Asnawi
Blood group antigen systems are not limited to the ABO blood groups. There is increasing interest in the detection of extended blood group systems on the red cell surface. The conventional method used to determine extended blood group antigens or red cell phenotype is by serological testing, which is based on the detection of visible haemagglutination or the presence of haemolysis. However, this technique has many limitations due to recent exposure to donor red cell, certain drugs or medications or other diseases that may alter the red cell membrane...
April 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28456469/application-of-a-portable-microscopic-cell-counter-for-the-counting-of-residual-leukocytes-in-leukoreduced-apheresis-platelet-concentrates-in-a-hospital-blood-bank
#6
Sejong Chun, Eun-Young Kim, Seung-Yeon Cha, Ji-Young Seo, Hong Hoe Koo, Duck Cho
While a portable microscopic cell counter has been evaluated to enumerate residual white blood cells (WBCs) in red blood cells and platelet concentrates at blood centers, it has not yet been assessed in a hospital blood bank. We investigated the performance of this device and evaluated its accuracy, along with its benefits in time management. Residual WBCs from each of 100 apheresis platelet specimens were measured manually using a Nageotte chamber, along with flow cytometry methods and an ADAM-rWBC automated instrument (NanoEnTek, Seoul, South Korea)...
April 7, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28428031/the-effect-of-hypoxia-preconditioning-on-the-neural-and-stemness-genes-expression-profiling-in-human-umbilical-cord-blood-mesenchymal-stem-cells
#7
Maryam Kheirandish, Somaie Piri Gavgani, Shahram Samiee
In recent years, human umbilical cord blood-derived mesenchymal stem cell (hUB-MSCs) has been regarded as an alternative source for stem cell therapy. In this study, we evaluated the effect of hypoxia preconditioning (HPC) on the expression of Nt-3, GFAP, Nestin, Oct-4 and Nanog genes and proliferative capacity of hUB-MSCs in comparison with normoxic conditions. HPC+Hypoxia protocol includes cultured hUB-MSCs for 15min at 2.5% O2 and after that reoxygenation for 30min at 21% O2 (HPC), and then hypoxia preconditioned hUB-MSCs subjected to 2...
March 31, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28433405/epidemiology-of-toxoplasma-gondii-among-blood-donors-in-iran-a-systematic-review-and-meta-analysis
#8
REVIEW
Akram Mansouri, Mohammad Reza Adhami Mojarad, Gholamreza Badfar, Lila Abasian, Shoboo Rahmati, Wesam Kooti, Mohammad Hossein YektaKooshali, Ali Soleymani, Milad Azami
INTRODUCTION: Asymptomatic Toxoplasma gondii transmitted from blood donors to receiving patients has become a concern. Numerous articles have been published on the epidemiology of T. gondii in blood donors in Iran and a systematic review of the results shows quite different findings, hence this study was conducted to determine the seroprevalence of T. gondii in Iranian blood donors using meta-analysis. METHODS: We searched for epidemiological studies that were published until July 2016 in eight English databases including: Scopus, PubMed, Ovid, Science Direct, Cochrane, Web of Science, Springer, Wiley Online Library, and four Iranian databases: Magiran, Iranmedex, SID and Medlib as well as Google Scholar...
March 29, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28392149/considerations-in-pediatrics
#9
EDITORIAL
Gail Rock
No abstract text is available yet for this article.
March 24, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28392150/factual-reflections-and-recommendations-on-extracorporeal-photopheresis-in-pediatrics
#10
REVIEW
Irena Sniecinski, Jerard Seghatchian
One of the biggest challenges in evaluating available literature on extracorporeal photopheresis (ECP) practices in pediatric patients is the marked heterogeneity of approaches to the patient evaluation, procedural aspects and apheresis product analysis. These issues are most relevant in ECP management in children with graft versus host disease (GVHD) after hematopoietic stem cell transplantation. Extracorporeal photopheresis in pediatric patients is considered relatively safe with few adverse effects reported from retrospective or observational studies...
March 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28372930/apheresis-education-one-center-curriculum-design-experience
#11
REVIEW
Rosaleen Nemec
There is little published in regards to apheresis education and curriculum for nursing. As more importance is placed on education, competency and skills for apheresis through accreditation processes, institutions are left to determine the educational requirements needed for nursing. Working with limited resources, one center has designed a comprehensive apheresis curriculum program that encompasses skills and theory for the novice to experienced learner. Utilizing existing hospital education and incorporating it into the apheresis curriculum was designed to meet the needs of the patient population, nurses and hospital...
March 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28389206/residual-risk-of-hiv-hcv-and-hbv-in-canada
#12
Sheila F O'Brien, Qi-Long Yi, Wenli Fan, Vito Scalia, Mindy Goldman, Margaret A Fearon
BACKGROUND: Residual risk is estimated as the product of the incidence and the infectious window period, the time during which a blood donation could be infectious but the assay may not detect it. In 2011 nucleic acid multiplex testing (MPX) was implemented in 6 unit minipools (previously 24 unit minipools). MPX also included hepatitis B (HBV) NAT for the first time (complementing HBsAg screening) in addition to HIV-1 and hepatitis C (HCV) as before. We aimed to estimate window period risk-day equivalents for MPX, and the residual risk of viral infections in blood donations updated to reflect current incidence and testing...
March 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28366590/increasing-use-of-therapeutic-apheresis-as-a-liver-saving-modality
#13
Hyun-Ji Lee, Kyung-Hwa Shin, Duyeal Song, Sun-Min Lee, Chulhun L Chang, Chong Woo Chu, Je Ho Ryu, Tae Bum Lee, Yong-Mok Park, Kwang Ho Yang, Byung Hyun Choi, Hyung-Hoi Kim
INTRODUCTION: Therapeutic plasma exchange (TPE) is used for temporary support of liver function in patients presenting with early graft dysfunction after liver transplantation (LT) or liver surgery. We analyzed the effect of therapeutic apheresis on patients with liver disease. METHODS: Between January 2011 and August 2016, 93 apheresis procedures were performed for 26 patients at our institution. Anti-ABO isoagglutination immunoglobulin (Ig) M titer was checked using a type A and type B 3% red blood cell (RBC) suspension in saline with two-fold serial dilutions of patient serum...
March 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28347649/the-effect-of-intraarticular-serum-rich-in-growth-factors-srgf-on-knee-osteoarthritis-in-the-rat-model
#14
Shahrzad Azizi, Reza Kheirandish, Alireza Farsinejad, Najmeh Rasouli
Osteoarthritis (OA) is a degenerative joint disease with high incidence in world. Various treatments have been used for decreasing pain and improving physical function without clearly beneficial evidences. Nowadays, platelet-rich therapy is used as a novel approach in field of regenerative medicine. The present study evaluated the effect of intraarticular serum rich in growth factors (SRGF) on the monosodium iodoacetate induced-osteoarthritis in rat model. SRGF was injected 3 times weekly. Femorotibial joints were examined 2 weeks after last injection...
March 12, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28428030/complement-inhibition-with-eculizumab-for-thrombotic-microangiopathy-rescues-a-living-donor-kidney-transplant-in-a-patient-with-antiphospholipid-antibody-syndrome
#15
Praveen Ramakrishnan Geethakumari, Patrick Mille, Rakesh Gulati, Srikanth Nagalla
Antiphospholipid antibody syndrome (APS) is an enigmatic heterogeneous disorder despite several revelations in its pathobiology. Renal transplantation in patients with APS has been notoriously difficult due to the high risk of development of thrombotic microangiopathy (TMA), which is often refractory to conventional treatment modalities such as aggressive anticoagulation and plasmapheresis. We describe a case of a 58-year-old male with secondary APS undergoing living unrelated renal transplantation for end-stage renal disease from lupus nephritis...
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28363590/evolving-concepts-of-the-rbc-storage-lesion-using-omics-and-other-novel-diagnostic-tools
#16
REVIEW
Jerard Seghatchian
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28359603/balance-of-the-unsuccessful-systematization-of-measurement-uncertainty-in-medical-laboratories
#17
LETTER
Paulo Pereira, Jerard Seghatchian
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28347648/sarode-honoured-by-american-society-of-hematology
#18
EDITORIAL
G Rock, Ravi Sarode
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28343936/hemolysis-in-six-week-old-autologous-red-blood-cell-components-questioned-worth-addressing-the-issue-of-homologous-components-as-well
#19
REVIEW
Olivier Garraud
No abstract text is available yet for this article.
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28363591/extracellular-vesicle-characteristics-in-stored-red-blood-cell-concentrates-are-influenced-by-the-method-of-detection
#20
REVIEW
Ruqayyah J Almizraq, Jerard Seghatchian, Jelena L Holovati, Jason P Acker
Extracellular vesicles (EVs), including microvesicles and exosomes, are small phospholipid vesicles (≤1μm in diameter) that are present in blood products, accumulate during storage, and have a potential transfusion-related immunomodulatory role. Knowledge of EVs in stored blood products is limited due to the challenges and difficulties in detecting these heterogeneous submicron-sized vesicles. The aim of this study was to assess the impact of different approaches to characterize EVs in stored RBC products...
March 9, 2017: Transfusion and Apheresis Science
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