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Current Cancer Drug Targets

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https://www.readbyqxmd.com/read/29749314/glycolysis-inhibition-as-a-strategy-for-hepatocellular-carcinoma-treatment
#1
Andreia Alves, Ana Catarina Mamede, Marco Alves, Pedro F Oliveira, Sandra Moreira Rocha, Filomena Botelho, Claudio Jorge Maia
Hepatocellular carcinoma (HCC) is the most frequently detected primary malignant liver tumor, representing a worldwide public health problem due to its high morbidity and mortality rates. The HCC is commonly detected in advanced stage, precluding the use of treatments with curative intent. For this reason, it is crucial to find effective therapies for HCC. Cancer cells have a high dependence of glycolysis for ATP production, especially under hypoxic environment. Such dependence provides a reliable possible strategy to specifically target cancer cells based on the inhibition of glycolysis...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29714146/prdm14-a-potential-target-for-cancer-therapy
#2
Mengting Ou, Shun Li, Liling Tang
PRDM14 belongs to PR domain-containing (PRDM) family. Although a precise understanding is focused on the function of PRDM14 maintains stemness and pluripotency in embryonic stem cells via epigenetic mechanisms, there are growing experimental evidences have been linked PRDM14 to human cancers. In adults, PRDM14 is low expression in human tissues. Aberrant PRDM14 expression is connected with various malignant histological types and solid cancers, where PRDM14 can act as a driver of oncogenic processes. Overexpression of RPDM14 enhanced cancer cells growth and reduced cancer cells sensitive to chemotherapeutic agents...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29714145/biological-activity-of-the-novel-vinca-alkaloids-4-chlorochablastine-und-4-chlorochacristine
#3
Gracia Montag, Helga Stopper, Quoc Anh Ngo, Henning Hintzsche
Vinca alkaloids are important cancer drugs belonging to the class of antimitotic agents. The most commonly used substances are vinblastine and vincristine, other compounds are vinorelbine and vinflunine. All of them are very effective drugs but their use is limited by severe side-effects including neurotoxicity and bone marrow depression. Therefore, it is very important to develop novel vinca alkaloids with similar efficacy but lower toxicity. Here, we analyzed two new compounds, 4-chlorochablastine and 4-chlorochacristine, with regard to their biological activity...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29714144/epigenetics-in-metastatic-breast-cancer-its-regulation-and-implications-in-diagnosis-prognosis-and-therapeutics
#4
Yuan Seng Wu, Zhong Yang Lee, Lay-Hong Chuah, Chun Wai Mai, Siew Ching Ngai
Despite advances in the treatment regimen, the high incidence rate of breast cancer (BC) deaths is mostly caused by metastasis. Recently, the aberrant epigenetic modifications, which involve DNA methylation, histone modifications and microRNA (miRNA) regulations become attractive targets to treat metastatic breast cancer (MBC). In this review, the epigenetic alterations of DNA methylation, histone modifications and miRNA regulations in regulating MBC is discussed. The preclinical and clinical trials of epigenetic drugs such as the inhibitor of DNA methyltransferase (DNMTi) and the inhibitor of histone deacetylase (HDACi), as a single or combined regimen with other epigenetic drug or standard chemotherapy drug to treat MBCs are discussed...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29714143/cutaneous-application-of-celecoxib-for-inflammatory-and-cancer-diseases
#5
Oliesia Gonzales Quinones, Maria Bernadete Riemma Pierre
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) and particularly selective cyclooxygenase-2 (COX-2) inhibitors such as celecoxib (Cxb) are considered promising cancer chemopreventive for colon, breast, prostate, lung, and skin cancers. However, the clinical application to the prevention is limited by concerns about safety, potential to serious toxicity (mainly for healthy individuals), efficacy and optimal treatment regimen. Cxb exhibits advantages as potent anti-inflammatory and gastrointestinal tolerance compared with conventional NSAID's...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29714142/efficacy-and-safety-of-antigen-specific-immunotherapy-in-the-treatment-of-patients-with-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#6
Bing-Di Yan, Xiao-Feng Cong, Sha-Sha Zhao, Meng Ren, Zi-Ling Liu, Zhi Li, Chen Chen, Lei Yang
BACKGROUND AND OBJECTIVE: We performed this systematic review and meta-analysis to assess the efficacy and safety of antigen-specific immunotherapy (Belagenpumatucel-L, MAGE-A3, L-BLP25, and TG4010) in the treatment of patients with non-small-cell lung cancer (NSCLC). METHOD: A comprehensive literature search on PubMed, Embase, and Web of Science were conducted. Eligible studies were clinical trials of patients with NSCLC who received the antigen-specific immunotherapy...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29714141/blocking-il-6-gp130-signaling-inhibits-cell-viability-proliferation-glycolysis-and-colony-forming-activity-in-human-pancreatic-cancer-cells
#7
Xiang Chen, Jilai Tian, Gloria H Su, Jiayuh Lin
BACKGROUND: Elevated production of the pro-inflammatory cytokine interleukin-6 (IL-6) and dysfunctions of IL-6 signaling promotes tumorigenesis and are associated with poor survival outcomes in multiple cancer types. Recent studies showed that the IL-6/GP130/STAT3 signaling pathway plays a pivotal role in pancreatic cancer development and maintenance. OBJECTIVE: We aim to develop effective treatments through inhibition of IL-6/GP130 signaling in pancreatic cancer...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29692251/the-anti-malarial-drug-artesunate-blocks-wnt-%C3%AE-catenin-pathway-and-inhibits-growth-migration-and-invasion-of-uveal-melanoma-cells
#8
Lei Zheng, Jingxuan Pan
BACKGROUND: Uveal melanoma is the most common primary intraocular malignancy in adults. So far, there have been no effective targeted therapeutic agents in patients with uveal melanoma. Artesunate is a semi-synthetic derivative of artemisinin extracted from traditional Chinese medicine Artemisia annua L for treatment of severe and multidrug-resistant malaria. Besides its anti-malarial activity, artesunate is identified as an anti-cancer drug due to the inhibition of Wnt/b-catenin pathway in multiple types of cancer...
April 25, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29557750/interrupting-the-fgf19-fgfr4-axis-to-therapeutically-disrupt-cancer-progression
#9
Liwei Lang, Austin Y Shull, Yong Teng
Coordination between amplification of the fibroblast growth factor FGF19, overexpression of its corresponding receptor FGFR4, and hyperactivation of the downstream transmembrane enzyme β-klotho have been found to play pivotal roles in mediating tumor development and progression. Aberrant FGF19-FGFR4 signaling has been implicated in driving specific tumorigenic events including cancer cell proliferation, apoptosis resistance, and metastasis by activating a myriad of downstream signaling cascades. As an attractive target, several strategies implemented to disrupt the FGF19-FGFR4 axis have been developed in recent years, and FGF19-FGFR4 binding inhibitors are being intensely evaluated for their clinical use in treating FGF19-FGFR4 implicated cancers...
March 18, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29644941/role-of-micrornas-in-treatment-response-in-prostate-cancer
#10
Anshuli Razdan, Paul de Souza, Tara Laurie Roberts
Prostate cancer (PCa) is the most common non-skin cancer in men worldwide, resulting in significant mortality and morbidity. Depending on the grade and stage of the cancer, patients may be given radiation therapy, hormonal therapy, or chemotherapy. However, more than half these patients develop resistance to treatment, leading to disease progression and metastases, often with lethal consequences. MicroRNAs (miRNAs) are short, non-coding RNAs, which regulate numerous physiological as well as pathological processes, including cancer...
March 15, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29521235/metastatic-site-location-influences-the-diagnostic-accuracy-of-ctdna-egfr-mutation-testing-in-nsclc-patients-a-pooled-analysis
#11
Francesco Passiglia, Sergio Rizzo, Christian Rolfo, Antonio Galvano, Enrico Bronte, Lorena Incorvaia, Angela Listi, Nadia Barraco, Marta Castiglia, Valentina Calo, Viviana Bazan, Antonio Russo
BACKGROUND: Recent studies evaluated the diagnostic accuracy of circulating tumor DNA (ctDNA) in the detection of epidermal growth factor receptor (EGFR) mutations from plasma of NSCLC patients, overall showing a high concordance as compared to standard tissue genotyping. However it is less clear if the location of metastatic site may influence the ability to identify EGFR mutations in plasma. OBJECTIVE: This pooled analysis aims to evaluate the association between the metastatic site location and the sensitivity of ctDNA analysis in detecting EGFR mutations in NSCLC patients...
March 8, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29521234/noxa-role-in-cancer-pathogenesis-and-treatment
#12
Rami Z Morsi, Rouba Hage-Sleiman, Hadile Kobeissy, Ghassan Dbaibo
The B-cell lymphoma 2 (Bcl-2) family proteins play an important role in regulating apoptosis, or programmed cell death, in response to several extracellular and intracellular signals. These proteins are either pro-apoptotic or anti-apoptotic. The pro-apoptotic Noxa is a Bcl-2 family protein that belongs to a subclass of BH3-only proteins. Noxa induces apoptosis via p53-dependent and/or p53-independent mechanisms. While Noxa may play a limited role in apoptosis, it is a crucial player that interacts with several proteins in the apoptosis pathway, highlighting its importance in the pathogenesis and treatment of certain cancers...
March 7, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29521233/parp-inhibitors-for-the-treatment-of-ovarian-cancer
#13
Laura Cortesi, Angela Toss, Iole Cucinotto
The standard of treatment for advanced ovarian cancer is represented by optimal surgical debulking preceded or followed by chemotherapeutic regimens including taxanes and platinum agents, possibly associated with bevacizumab and/or intraperitoneal therapy. Despite this comprehensive treatment strategy, almost 75% of patients relapse or progress and are therefore candidates for a second-line treatment, showing, at this point, less chemo-sensitivity and worse prognosis. An interesting approach to improve outcomes of these patients has been developed in the last decade, in BRCA-related ovarian cancer...
March 7, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29521232/role-of-mir-193a-in-cancer-complexity-and-factors-control-the-pattern-of-its-expression
#14
Afraa Mamoori, Vinod Gopalan, Alfred K-Y Lam
BACKGROUND: There is emerging data suggest that the non-coding RNA (microRNA 193a or miR-193a) plays key roles in different types of cancers. OBJECTIVE: This review aims to investigate the functional significance of miR-193a in different cancers according to the information of literature. METHOD: All the literature concerning miR-193a in cancer in PubMed are analysed. RESULTS: Several studies proved the association of miR-193a expression patterns with cancer's stages, grades, response to the chemotherapy and even patient survival...
March 7, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29517470/editorial-cancer-epigenetics
#15
EDITORIAL
Aamir Ahmad
No abstract text is available yet for this article.
2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29517469/preface
#16
Ruiwen Zhang
No abstract text is available yet for this article.
2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29484998/foxp2-promotes-tumor-proliferation-and-metastasis-by-targeting-grp78-in-triple-negative-breast-cancer
#17
Jiali Wu, Peng Liu, Hailin Tang, Zeyu Shuang, Qingsheng Qiu, Lijuan Zhang, Cailu Song, Lingrui Liu, Xiaoming Xie, Xiangsheng Xiao
BACKGROUND: FOXP2, a member of the forkhead box P (FOXP) family, has been reported to be important in breast cancer. However, its exact mechanisms and pathways remain unclear. OBJECTIVE: To investigate the effect of FOXP2 on tumor proliferation and metastasis in triplenegative breast cancer (TNBC) and study its underlying molecular mechanism. METHODS: We first used qRT-PCR to detect FOXP2 expression in TNBC cell lines and tissues. Then we conducted cell proliferation assays, colony formation assays, and transwell assays to analyze the effects of FOXP2 expression in TNBC cells...
2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29457568/editorial-oncolytic-virus-and-gene-thearapy-application-update-2018
#18
EDITORIAL
Masato Abei
No abstract text is available yet for this article.
2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29295697/towards-prevention-of-ovarian-cancer
#19
Aus Tariq Ali
Ovarian cancer is the leading cause of death of all gynaecological cancers. To date, there is no reliable, specific screening procedure for detecting ovarian cancer. The risk factors of ovarian cancer include modifiable and non-modifiable factors. The main goal of the ovarian cancer prevention program is to significantly reduce the risk of development of ovarian cancer and other cancers such as breast and/or peritoneal cancer. The application of non-surgical preventive approaches such as oral contraceptives, parity and breastfeeding has been shown to be highly protective against ovarian cancer development...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29295696/antibody-based-epcam-targeted-therapy-of-cancer-review-and-update
#20
Shirin Eyvazi, Safar Farajnia, Siavoush Dastmalchi, Farzad Kanipour, Habib Zarredar, Mojgan Bandehpour
Todays, after four decades of the discovery of monoclonal antibodies by Kohler and Milstein in 1975, a dozen of antibodies are used in cancer targeted therapy with different strategies. The success of these antibodies depends on the specificity of antigens expressed on the cancer cells. Epithelial cell adhesion molecule (EpCAM), a homophilic cell-cell adhesion glycoprotein is a well- known tumor antigen, which expresses on epithelial tumors and circulating tumor cells as well as cancer stem cells. The EpCAM signaling pathway is associated with proliferation, differentiation and adhesion of epithelial cancer cells...
January 1, 2018: Current Cancer Drug Targets
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