journal
MENU ▼
Read by QxMD icon Read
search

Current Diabetes Reports

journal
https://www.readbyqxmd.com/read/30232652/autonomic-regulation-of-glucose-homeostasis-a-specific-role-for-sympathetic-nervous-system-activation
#1
REVIEW
Revathy Carnagarin, Vance B Matthews, Lakshini Y Herat, Jan K Ho, Markus P Schlaich
PURPOSE OF REVIEW: Cardiometabolic disorders such as obesity, metabolic syndrome and diabetes are increasingly common and associated with adverse cardiovascular outcomes. The mechanisms driving these developments are incompletely understood but likely to include autonomic dysregulation. The latest evidence for such a role is briefly reviewed here. RECENT FINDINGS: Recent findings highlight the relevance of autonomic regulation in glucose metabolism and identify sympathetic activation, in concert with parasympathetic withdrawal, as a major contributor to the development of metabolic disorders and an important mediator of the associated adverse cardiovascular consequences...
September 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30232649/rethinking-bile-acid-metabolism-and-signaling-for-type-2-diabetes-treatment
#2
REVIEW
Karolina E Zaborska, Bethany P Cummings
PURPOSE OF REVIEW: Herein, we review the role of FXR and TGR5 in the regulation of hepatic bile acid metabolism, with a focus on how our understanding of bile acid metabolic regulation by these receptors has evolved in recent years and how this improved understanding may facilitate targeting bile acids for type 2 diabetes treatment. RECENT FINDINGS: Bile acid profile is a key regulator of metabolic homeostasis. Inhibition of expression of the enzyme that is required for cholic acid synthesis and thus determines bile acid profile, Cyp8b1, may be an effective target for type 2 diabetes treatment...
September 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30232630/advancing-measurement-of-diabetes-at-the-population-level
#3
REVIEW
Mohammed K Ali, Karen R Siegel, Michael Laxy, Edward W Gregg
PURPOSE: The measurement and estimation of diabetes in populations guides resource allocation, health priorities, and can influence practice and future research. To provide a critical reflection on current diabetes surveillance, we provide in-depth discussion about how upstream determinants, prevalence, incidence, and downstream impacts of diabetes are measured in the USA, and the challenges in obtaining valid, accurate, and precise estimates. FINDINGS: Current estimates of the burden of diabetes risk are obtained through national surveys, health systems data, registries, and administrative data...
September 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30232567/enteroviral-infections-as-a-trigger-for-type-1-diabetes
#4
REVIEW
Teresa Rodriguez-Calvo
PURPOSE OF REVIEW: To provide an overview of studies that have detected enteroviruses (EV) in samples from people with type 1 diabetes (T1D), the techniques they have used, and which challenges they have encountered. RECENT FINDINGS: Recent studies have detected EVs in serum, blood, stools, nasal swabs, and pancreas of people with T1D before or around clinical onset of disease, indicating that an association between EV infections and T1D exists. However, definitive evidence for its role as disease triggers is lacking...
September 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30229480/building-toward-a-population-based-approach-to-diabetes-screening-and-prevention-for-us-adults
#5
REVIEW
Michael E Bowen, Julie A Schmittdiel, Jeffrey T Kullgren, Ronald T Ackermann, Matthew J O'Brien
PURPOSE OF REVIEW: Evidence-based treatments for prediabetes can prevent and delay the development of type 2 diabetes in adults. In this review, we propose a framework for population-based diabetes prevention that links screening and prevention activities across key stakeholders. We also discuss gaps in current practice, while highlighting opportunities to improve diabetes screening and prevention efforts population-wide. RECENT FINDINGS: Awareness of diabetes risk is low, and many adults with prediabetes are not identified through existing screening efforts...
September 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30229351/issues-in-defining-the-burden-of-prediabetes-globally
#6
REVIEW
Justin B Echouffo-Tcheugui, Andre P Kengne, Mohammed K Ali
PURPOSE OF REVIEW: Using a global perspective, this review collates evidence on the heterogeneity of prediabetes definitions and diagnostic methods, their clinical and public health implications, and discusses possible options for improvement. RECENT FINDINGS: Our review notes that the concept of prediabetes is increasingly recognized worldwide, but against a background of non-uniform definition and diagnostic criteria. This results in widely varying burden estimation...
September 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30229378/will-genetic-engineering-carry-xenotransplantation-of-pig-islets-to-the-clinic
#7
REVIEW
Elisabeth Kemter, Joachim Denner, Eckhard Wolf
PURPOSE OF REVIEW: Porcine islets represent a potentially attractive beta-cell source for xenotransplantation into patients with type 1 diabetes, who are not eligible to islet allo-transplantation due to a lack of suitable human donor organs. Recent progress in genetic engineering/gene editing of donor pigs provides new opportunities to overcome rejection of xeno-islets, to improve their engraftment and insulin secretion capacity, and to reduce the risk for transmission of porcine endogenous retroviruses...
September 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30229352/cardiovascular-outcomes-trials-update-insights-from-the-devote-trial
#8
REVIEW
Anika Bilal, Richard E Pratley
PURPOSE OF REVIEW: The DEVOTE study compared the cardiovascular safety of two basal insulins, degludec, and glargine U100 in patients with type 2 diabetes (T2D) at high risk for cardiovascular disease (CVD). In this review, we summarize the results of DEVOTE and provide a clinical perspective. RECENT FINDINGS: DEVOTE was a phase 3b, multicenter, international, treat-to-target, double-blind, event-driven trial. Patients with T2D > 50 years of age with prior CVD or > 60 years of age with CVD risk factors were randomly assigned to receive either degludec (n = 3818) or insulin glargine U100 (n = 3819) and were followed until at least 633 positively adjudicated major adverse cardiovascular events (MACE; cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) accrued...
September 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30229314/vegetarian-diets-and-the-risk-of-diabetes
#9
REVIEW
Melissa D Olfert, Rachel A Wattick
PURPOSE OF REVIEW: Worldwide, diabetes has increased steadily and in recent years, drastically. The majority of diabetes cases are type 2 (T2DM), caused by modifiable risk factors such as diet. Vegetarian diets have been studied over the past few decades for their preventative and therapeutic effects on diabetes and may be more beneficial than medication for diabetes management. RECENT FINDINGS: A vegetarian diet characterized by whole plant foods is most beneficial for diabetes prevention and management...
September 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30229313/red-meat-consumption-heme-iron-intake-and-risk-for-diabetes-and-comorbidities
#10
REVIEW
Ranjita Misra, Padmini Balagopal, Sudha Raj, Thakor G Patel
PURPOSE OF REVIEW: To examine the role of red meat consumption, especially heme iron intake, and risk for diabetes and its comorbidities. RECENT FINDINGS: Studies consistently show that consumption of red meat has been contributory to a multitude of chronic conditions such as diabetes, CVD, and malignancies. There are various emerging reasons that strengthen this link-from the basic constituents of red meat like the heme iron component, the metabolic reactions that take place after consumption, and finally to the methods used to cook it...
September 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30218282/preventing-type-2-diabetes-with-home-cooking-current-evidence-and-future-potential
#11
REVIEW
Rani Polak, Amir Tirosh, Barbara Livingston, David Pober, James E Eubanks, Julie K Silver, Kaya Minezaki, Roni Loten, Edward M Phillips
PURPOSE OF REVIEW: Various dietary regimes have proven effective in preventing diabetes, yet its prevalence is growing. This review's goals are to examine the relationship between home cooking and diabetes and to present the literature on home cooking education programs as a novel strategy to improve adherence to healthy nutrition, thus decreasing the risk of diabetes. RECENT FINDINGS: Consumption of home-cooked food is linked to healthier nutrition and decreased risk of diabetes...
September 14, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30215149/altered-gut-microbiota-in-type-2-diabetes-just-a-coincidence
#12
REVIEW
Antonio Sircana, Luciana Framarin, Nicola Leone, Mara Berrutti, Francesca Castellino, Renato Parente, Franco De Michieli, Elena Paschetta, Giovanni Musso
PURPOSE OF REVIEW: In the last decade many studies have suggested an association between the altered gut microbiota and multiple systemic diseases including diabetes. In this review, we will discuss potential pathophysiological mechanisms, the latest findings regarding the mechanisms linking gut dysbiosis and type 2 diabetes (T2D), and the results obtained with experimental modulation of microbiota. RECENT FINDINGS: In T2D, gut dysbiosis contributes to onset and maintenance of insulin resistance...
September 13, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30194541/metabolic-abnormalities-in-diabetes-and-kidney-disease-role-of-uremic-toxins
#13
REVIEW
Laetitia Koppe, Denis Fouque, Christophe O Soulage
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is characterized by the accumulation of uremic retention solutes (URS) and is associated with perturbations of glucose homeostasis even in absence of diabetes. The underlying mechanisms of insulin resistance, β cell failure, and increase risk of diabetes in CKD, however, remain unclear. Metabolomic studies reported that some metabolites are similar in CKD and diabetic kidney disease (DKD) and contribute to the progression to end-stage renal disease...
September 8, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30194499/optimal-obstetric-management-for-women-with-diabetes-the-benefits-and-costs-of-fetal-surveillance
#14
REVIEW
Ukachi N Emeruwa, Chloe Zera
PURPOSE OF REVIEW: To elaborate on the risks and benefits associated with antenatal fetal surveillance for stillbirth prevention in women with diabetes. RECENT FINDINGS: Women with pregestational diabetes have a 3- to 5-fold increased odds of stillbirth compared to women without diabetes. The stillbirth risk in women with gestational diabetes (GDM) is more controversial; while recent data suggest the odds for stillbirth are approximately 50% higher in women with GDM at term (37 weeks and beyond) than in those without GDM, it is unclear if this risk is seen in women with optimal glycemic control...
September 7, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30187176/diabetes-treatment-in-the-elderly-incorporating-geriatrics-technology-and-functional-medicine
#15
REVIEW
Willy Marcos Valencia, Diana Botros, Maria Vera-Nunez, Stuti Dang
PURPOSE OF REVIEW: The current approach to diabetes in the elderly incorporates components from the comprehensive geriatric approach. The most updated guidelines from the American Diabetes Association reflect influence from the consensus made in 2012 with the American Geriatrics Society. Notably, the framework included the evaluation for geriatric syndromes (falls and urinary incontinence), functional and cognitive abilities. The goal for this review is to provide an updated summary of treatment strategies for community-dwelling older adults...
September 5, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30187134/biomarkers-in-islet-cell-transplantation-for-type-1-diabetes
#16
REVIEW
Fatimah T AlRashidi, Kathleen M Gillespie
PURPOSE OF REVIEW: Islet transplantation, an important approach to achieve insulin independence for individuals with type 1 diabetes, is limited by the lack of accurate biomarkers to track beta-cell death post islet infusion. In this review, we will discuss existing and recently described biomarkers. RECENT FINDINGS: As beta cells are killed by the immune system, fragments of beta cell-specific cell-free DNA and proteins are released into the periphery. Several different strategies to identify these fragments have been described...
September 5, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30173405/correction-to-metabolic-abnormalities-in-the-pathogenesis-of-type-1-diabetes
#17
Shuyao Zhang, Clayton E Mathews
The original version of this article unfortunately contained a mistake in the author group section. Shuyao Zhang's family name was misspelled as "Zheng".
September 1, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30171481/cardiovascular-effects-of-different-glp-1-receptor-agonists-in-patients-with-type-2-diabetes
#18
REVIEW
Gül Bahtiyar, Jean Pujals-Kury, Alan Sacerdote
PURPOSE OF REVIEW: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have positive effects on weight loss, blood pressure, hyperlipidemia, and glycemic control. They exhibit a broad range of effects on the cardiovascular system that are independent of changes in blood glucose. Cardiovascular outcome trials have demonstrated safety of GLP-1 RAs but results for cardiovascular efficacy were varied. The aim of the present review is the assessment of the effects of GLP-1 RAs on cardiovascular risk factors, and major cardiovascular events...
August 31, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30168021/immune-mechanisms-and-pathways-targeted-in-type-1-diabetes
#19
REVIEW
Laura M Jacobsen, Brittney N Newby, Daniel J Perry, Amanda L Posgai, Michael J Haller, Todd M Brusko
PURPOSE OF REVIEW: The immunosuppressive agent cyclosporine was first reported to lower daily insulin dose and improve glycemic control in patients with new-onset type 1 diabetes (T1D) in 1984. While renal toxicity limited cyclosporine's extended use, this observation ignited collaborative efforts to identify immunotherapeutic agents capable of safely preserving β cells in patients with or at risk for T1D. RECENT FINDINGS: Advances in T1D prediction and early diagnosis, together with expanded knowledge of the disease mechanisms, have facilitated trials targeting specific immune cell subsets, autoantigens, and pathways...
August 30, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30167798/the-impact-of-childhood-and-adolescent-obesity-on-cardiovascular-risk-in-adulthood-a-systematic-review
#20
REVIEW
Adir Sommer, Gilad Twig
PURPOSE OF REVIEW: Adult obesity and cardiovascular diseases are closely linked. Yet, the relationship of childhood and adolescent obesities with cardiovascular diseases in adulthood requires additional evidence. The goal of the review is to inspect the relationship between childhood- and adolescent-increased body mass index (BMI) and cardiovascular risk factors, fatal and non-fatal cardiovascular diseases in adulthood. RECENT FINDINGS: Cardiovascular diseases in adulthood are linked by most of the studies to childhood and adolescent obesities...
August 30, 2018: Current Diabetes Reports
journal
journal
39539
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"