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Current Diabetes Reports

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https://www.readbyqxmd.com/read/29779190/therapeutic-strategies-for-modulating-the-extracellular-matrix-to-improve-pancreatic-islet-function-and-survival-after-transplantation
#1
REVIEW
Alexandra M Smink, Paul de Vos
PURPOSES OF REVIEW: Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve transplantation outcomes. This review discusses the current therapeutic strategies to modulate ECM components to improve islet engraftment. RECENT FINDINGS: Approaches applied are seeding islets in ECM of decellularized organs, supplementation of specific ECM components in polymeric scaffolds or immunoisolating capsules, and stimulating islet ECM production with specific growth factors or ECM-producing cells...
May 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29779155/prioritising-risk-factors-for-type-2-diabetes-causal-inference-through-genetic-approaches
#2
REVIEW
Laura B L Wittemans, Luca A Lotta, Claudia Langenberg
PURPOSE OF THE REVIEW: Causality has been demonstrated for few of the many putative risk factors for type 2 diabetes (T2D) emerging from observational epidemiology. Genetic approaches are increasingly being used to infer causality, and in this review, we discuss how genetic discoveries have shaped our understanding of the causal role of factors associated with T2D. RECENT FINDINGS: Genetic discoveries have led to the identification of novel potential aetiological factors of T2D, including the protective role of peripheral fat storage capacity and specific metabolic pathways, such as the branched-chain amino acid breakdown...
May 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29748905/diabetes-care-in-the-digital-era-a-synoptic-overview
#3
REVIEW
Farhad Fatehi, Anish Menon, Dominique Bird
PURPOSE OF REVIEW: Diabetes care is undergoing a remarkable transformation by the advancements in information and communications technology (ICT). The aim of this review is to provide a general overview of various ICT-based interventions for diabetes care, challenges of their adoption, and consider future directions. RECENT FINDINGS: A number of systematic reviews have examined studies on various aspects of telemedicine and eHealth for diabetes care, but they are generally focused on one specific type of technology application for diabetes care...
May 10, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29744612/maternal-non-glycemic-contributors-to-fetal-growth-in-obesity-and-gestational-diabetes-spotlight-on-lipids
#4
REVIEW
Linda A Barbour, Teri L Hernandez
PURPOSE OF REVIEW: Excess fetal growth is increasingly recognized as a risk factor for childhood obesity, and mounting evidence supports that maternal glucose is not the only driver. This review focuses on the role of clinically applicable maternal non-glycemic contributors to excess fetal growth, particularly lipids, in addition to amino acids (AA), insulin resistance, inflammation, maternal nutrition, and gestational weight gain (GWG) in obesity and gestational diabetes mellitus (GDM)...
May 9, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29737424/type-2-diabetes-in-youth-new-lessons-from-the-search-study
#5
REVIEW
Elizabeth T Jensen, Dana Dabelea
PURPOSE OF REVIEW: The purpose of this review is to provide an update on the recent body of evidence emerging for type 2 diabetes as identified through the SEARCH for Diabetes in Youth study. RECENT FINDINGS: This body of evidence illustrates that type 2 diabetes continues to increase in incidence, although this increase may be partially attributable to increased surveillance. Disease management is influenced by the transition from adolescent to adult care and psychosocial factors may also contribute...
May 8, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29696418/causes-of-emotional-eating-and-matched-treatment-of-obesity
#6
REVIEW
Tatjana van Strien
PURPOSE OF THE REVIEW: Eating in response to negative emotions (EE) may be an explanatory factor of the weight regain of many dieters. This narrative review presents evidence on possible causes of EE and the association of EE with depression and obesity and discusses implications of these findings for the treatment of obesity. RECENT FINDINGS: Possible causes of EE are high dietary restraint, poor interoceptive awareness, alexithymia, emotion dysregulation and a reversed hypothalamic pituitary adrenal (HPA) stress axis...
April 25, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29671135/social-media-and-obesity-in-adults-a-review-of-recent-research-and-future-directions
#7
REVIEW
Molly E Waring, Danielle E Jake-Schoffman, Marta M Holovatska, Claudia Mejia, Jamasia C Williams, Sherry L Pagoto
PURPOSE OF REVIEW: Social media is widely used and has potential to connect adults with obesity with information and social support for weight loss and to deliver lifestyle interventions. The purpose of this review is to summarize recent observational and intervention research on social media and obesity. RECENT FINDINGS: Online patient communities for weight loss abound but may include misinformation. Systematic reviews and meta-analyses suggest that social media-delivered lifestyle interventions modestly impact weight, yet how social media was used and participant engagement varies widely...
April 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29671131/diabetes-in-south-asians-phenotype-clinical-presentation-and-natural-history
#8
REVIEW
Ranjit Unnikrishnan, Prasanna Kumar Gupta, Viswanathan Mohan
PURPOSE OF REVIEW: South Asia is one of the epicenters of the global diabetes pandemic. Diabetes in south Asians has certain peculiar features with respect to its pathophysiology, clinical presentation, and management. This review aims to summarize some of the recent evidence pertaining to the distinct diabetes phenotype in south Asians. RECENT FINDINGS: South Asia has high incidence and prevalence rates of diabetes. The progression from "pre-diabetes" to diabetes also occurs faster in this population...
April 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29671100/pediatric-type-2-diabetes-in-japan-similarities-and-differences-from-type-2-diabetes-in-other-pediatric-populations
#9
REVIEW
Tatsuhiko Urakami
PURPOSE OF REVIEW: To review clinical characteristics of pediatric type 2 diabetes in Japan. RECENT FINDINGS: It is well recognized that Asian populations, particularly the Japanese, have a higher incidence of childhood type 2 diabetes. Of note, most Asian populations show a higher incidence of pediatric type 2 diabetes than that of type 1 diabetes. However, a current report in the USA demonstrated a dramatic increase in the incidence of young people with type 2 diabetes in recent years...
April 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29671082/sex-differences-in-the-burden-and-complications-of-diabetes
#10
REVIEW
Sanne A E Peters, Mark Woodward
PURPOSE OF THE REVIEW: To review the latest evidence on sex differences in the burden and complications of diabetes and discuss the potential explanations for the sex differences described. RECENT FINDINGS: Diabetes is a strong risk factor for vascular disease, with compelling evidence that the relative risks of vascular diseases conferred by diabetes are considerably greater in women than men. The mechanisms underpinning women's excess relative risk of vascular disease from diabetes are unknown...
April 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29671081/type-2-diabetes-mellitus-the-metabolic-syndrome-and-its-components-in-adult-survivors-of-acute-lymphoblastic-leukemia-and-hematopoietic-stem-cell-transplantations
#11
REVIEW
Bella Bielorai, Orit Pinhas-Hamiel
PURPOSE OF REVIEW: A growing number of pediatric acute lymphoblastic leukemia (ALL) and hematopoietic stem cell transplantation (HSCT) survivors reach adulthood and face long-term health-related problems. We review risk factors and the prevalence of the metabolic syndrome (MetS), a cluster of obesity-related comorbidities, including abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, impaired glucose metabolism, and type 2 diabetes in ALL and HSCT survivors. RECENT FINDINGS: Components of the MetS are already detected during the first year of ALL maintenance therapy and significantly worsen over time...
April 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29671076/sugar-sweetened-beverage-obesity-and-type-2-diabetes-in-children-and-adolescents-policies-taxation-and-programs
#12
REVIEW
Yilin Yoshida, Eduardo J Simoes
PURPOSE OF REVIEW: Obesity has grown at an alarming rate in children and adolescents. Concurrently, consumption on sugar-sweetened beverages (SSBs) also rose significantly. This review provides an overview of obesity and type 2 diabetes mellitus (T2DM) related to SSBs and current policies restricting SSBs in schools, school-based interventions, and taxation on reducing SSB intake and obesity. We also discuss challenges of and future steps for these initiatives. RECENT FINDINGS: Clinical and epidemiological studies suggest a strong association between SSB intake and obesity and T2DM...
April 18, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29654381/renal-effects-of-incretin-based-diabetes-therapies-pre-clinical-predictions-and-clinical-trial-outcomes
#13
REVIEW
Scott C Thomson, Volker Vallon
PURPOSE OF REVIEW: The purpose of this review is to correlate predictions based on pre-clinical data with outcomes from clinical trials that examine the effects of incretin-based diabetes treatments on the kidney. The incretin-based treatments include agonists of the glucagon-like peptide 1 receptor (GLP-1R) and inhibitors of the enzyme, dipeptidyl peptidase-4 (DPP-4). In addition, what is known about the incretin-based therapies will be compared to what is known about the renal effects of SGLT2 inhibitors...
April 13, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29589183/new-diabetes-therapies-and-diabetic-kidney-disease-progression-the-role-of-sglt-2-inhibitors
#14
REVIEW
Claire C J Dekkers, Ron T Gansevoort, Hiddo J L Heerspink
PURPOSE OF REVIEW: Sodium-glucose co-transporter 2 (SGLT-2) inhibitors have emerged as a promising drug class for the treatment of diabetic kidney disease. Developed originally as glucose-lowering drugs by enhancing urinary glucose excretion, these drugs also lower many other renal and cardiovascular risk factors such as body weight, blood pressure, albuminuria, and uric acid. Results from the EMPA-REG OUTCOME and CANVAS trials show that these salutary effects translate into a reduction in cardiovascular outcomes and have the potential to delay the progression of kidney function decline...
March 27, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29582176/hypoglycemia-prevention-by-algorithm-design-during-intravenous-insulin-infusion
#15
REVIEW
Susan Shapiro Braithwaite, Lisa P Clark, Thaer Idrees, Faisal Qureshi, Oluwakemi T Soetan
PURPOSE OF REVIEW: This review examines algorithm design features that may reduce risk for hypoglycemia while preserving glycemic control during intravenous insulin infusion. We focus principally upon algorithms in which the assignment of the insulin infusion rate (IR) depends upon maintenance rate of insulin infusion (MR) or a multiplier. RECENT FINDINGS: Design features that may mitigate risk for hypoglycemia include use of a mid-protocol bolus feature and establishment of a low BG threshold for temporary interruption of infusion...
March 26, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29582168/underutilized-and-under-threat-environmental-policy-as-a-tool-to-address-diabetes-risk
#16
REVIEW
Sabina Shaikh, Jyotsna S Jagai, Colette Ashley, Shuhan Zhou, Robert M Sargis
PURPOSE OF REVIEW: Diabetes is a burgeoning threat to public health in the USA. Importantly, the burden of diabetes is not equally borne across society with marked disparities based on geography, race/ethnicity, and income. The etiology of global and population-specific diabetes risk remains incompletely understood; however, evidence linking environmental toxicants acting as endocrine-disrupting chemicals (EDCs), such as particulate matter and arsenic, with diabetes suggests that environmental policies could play an important role in diabetes risk reduction...
March 26, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29564640/self-and-social-regulation-in-type-1-diabetes-management-during-late-adolescence-and-emerging-adulthood
#17
REVIEW
Deborah J Wiebe, Cynthia A Berg, Daniel Mello, Caitlin S Kelly
PURPOSE OF REVIEW: This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS: Problems in cognitive (e.g., executive function) and emotional (e.g., depressive symptoms) self-regulation are associated with poorer management, both at the between- and within-person levels...
March 21, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29564581/a-narrative-review-of-physician-perspectives-regarding-the-social-and-environmental-determinants-of-obesity
#18
REVIEW
Ashley H Noriea, Feenalie N Patel, Debra A Werner, Monica E Peek
PURPOSE OF REVIEW: Diet-related chronic diseases result from individual and non-individual (social, environmental, and macro-level) factors. Recent health policy trends, such as population health management, encourage assessment of the individual and non-individual factors that cause these diseases. In this review, we evaluate the physician's perspective on the individual and non-individual causes and management of obesity. RECENT FINDINGS: Physicians generally rated individual-level causes (i...
March 21, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29557063/renal-hyperfiltration-in-adolescents-with-type-2-diabetes-physiology-sex-differences-and-implications-for-diabetic-kidney-disease
#19
REVIEW
Petter Bjornstad, David Z Cherney
PURPOSE OF REVIEW: Compared to adult-onset type 2 diabetes (T2D), youth with T2D have a more aggressive phenotype with greater insulin resistance (IR), more rapid β cell decline, and higher prevalence of diabetic kidney disease (DKD). RECENT FINDINGS: Hyperfiltration is common in youth with T2D and predicts progressive DKD. Hyperfiltration is a consequence of early changes in intrarenal hemodynamic function, including increased renal plasma flow (RPF) and glomerular pressure...
March 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29536197/correction-to-hospital-readmission-of-patients-with-diabetes
#20
Daniel J Rubin
This article was originally published with errors that were introduced during the editing process. The corrected version of this article appears below.
March 13, 2018: Current Diabetes Reports
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