journal
MENU ▼
Read by QxMD icon Read
search

Current Molecular Medicine

journal
https://www.readbyqxmd.com/read/29110611/curcumin-inhibits-proliferation-and-epithelial-mesenchymal-transition-of-retinal-pigment-epithelial-cells-via-multiple-pathways
#1
X Zhou, X Kuang, C Long, W Liu, Y Tang, L Liu, H Liu, J He, Z Huang, Y Fan, Q Zhang, H Shen
Proliferative vitreoretinopathy (PVR) is a disease caused by de-differentiation, translocation and proliferation of several types of local cells. These cells form fibrocellular membranes resulting in detachment of retinal and vision loss. PVR occurs in 8%-10% of patients undergoing primary retinal detachment (RD) surgery and becomes a major obstacle for successful RD repair. Retinal pigment epithelial (RPE) cells are among the major cells which consist of fibrocellular membranes. Re-proliferation and Epithelial-mesenchymal transition (EMT) are the primary pathological alteration of RPE cells in PVR...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110610/vegfr1-signaling-regulates-il-4-mediated-arginase-1-expression-in-macrophages
#2
Y Zou, Q Chen, Z Ye, X Li, R Ju
Macrophages undergo polarization or activation in response to environmental stimuli, an essential process for proper immune response. Meanwhile, excessive activation of macrophages causes autoimmune diseases. It is therefore crucial to prevent over-activation of macrophage in order to maintain the proper immune response. Arginase 1 plays a critical role in coordinating the immune response by regulating availability of arginine. However, the mechanism of Arginase 1 regulation is poorly understood. In this study, we discovered the VEGFR1-mediated signaling suppressed IL-4-induced Arginase 1 expression...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110609/bmp3-is-required-for-integrity-of-blood-brain-barrier-by-promoting-pericyte-coverage-in-zebrafish-embryos
#3
D Lei, X Jin, L Wen, H Dai, Z Ye, G Wang
BACKGROUND: The compromise of blood brain barrier (BBB) integrity is often associated with human hemorrhage stroke and neurodegeneration diseases, including retina diseases, such as age-related macular degeneration and diabetic retinopathy. Brain pericytes play pivotal roles in regulation and maintenance of BBB integrity. However, the mechanisms underlying brain pericyte development to establish BBB integrity remain unclear. METHODS: zebrafish transgenic lines Tg(flk1:GFP; gata1:dsRed), Tg(flk1:GFP), Tg(fli1:GFP) and Tg(BRE:GFP) were used in this work...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110608/the-profile-of-angiogenic-factors-in-vitreous-humor-of-the-patients-with-proliferative-diabetic-retinopathy
#4
Y Yu, J Zhang, R Zhu, R Zhao, J Chen, J Jin, Y Tian, S B Su
OBJECTIVE: To explore the expression profile of angiogenic factors associated with proliferative diabetic retinopathy (PDR). METHODS: Undiluted vitreous humor samples were obtained from 10 diabetic patients with PDR (10 eyes) and 9 non-diabtic patients (9 eyes). The concentrations of 60 angiogenic factors in the vitreous humor samples were measured by RayBio Angiogenic Cytokine Antibody Array. Some differentially expressed factors were further confirmed in vitreous humor by enzyme-linked immunosorbent assay (ELISA)...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110607/serum-carotenoids-and-risks-of-diabetes-and-diabetic-retinopathy-in-a-chinese-population-sample
#5
C She, F Shang, K Zhou, N Liu
OBJECTIVE: Diabetes mellitus (DM) and diabetic retinopathy (DR) are associated with oxidative stress and carotenoids have antioxidant properties. This study aimed to test the relationship between serum carotenoid concentrations and the risk for DM and DR. METHODS: This is a cross-sectional study of the Chinese urban population. A total of 747 subjects, consisting of 272 DR patients, 190 diabetic patients without retinopathy, and 285 non-diabetes mellitus healthy controls, were recruited to this study...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110606/the-fate-of-in-situ-lens-regeneration-is-determined-by-capsulorhexis-size
#6
X Tan, Z Liu, Y Zhu, C Chen, S Huang, B Chen, Z Lin, J Chen, X Tang, B Qu, X Liu, L Luo, J Deng, F Shang, M Wu, W Chen, H Lin, Y Liu
BACKGROUND AND OBJECTIVE: Lens regeneration is an optimal strategy for cataract patients to regain visual acuity with accommodation. We recently designed a novel, minimally invasive capsulorhexis surgical method for cataract removal that achieved functional lens regeneration in human infants. However, small anterior capsulorhexis requires advanced surgical expertise. To know whether the quality of the regenerated lens can be maintained with enlarged anterior capsulorhexis, we investigated the shape and transparency of the regenerated lenses with different anterior capsulorhexis diameters (ACDs)...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110604/editorial-view-of-cellular-biology-through-the-eye
#7
EDITORIAL
F Shang
No abstract text is available yet for this article.
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110605/glutathiolation-triggers-proteins-for-degradation-by-the-ubiquitin-proteasome-pathway
#8
X Zhang, A Taylor, Y Liu, F Shang
Glutathione is a small antioxidant peptide in cells and it plays an important role in maintaining a reducing intracellular environment. Glutathione is also involved in the dynamic regulation of specific protein functions by reversible glutathiolation of certain proteins in response to oxidative stress. The purpose of this work is to mechanistically investigate the effects of glutathiolation on the susceptibility of proteins to degradation by the ubiquitin-proteasome pathway (UPP). The data show that γC-crystallin and carbonic anhydrase III were barely degraded by the UPP without modifications, but both were rapidly degraded by the UPP after glutathiolation...
November 1, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110603/characterization-of-polyethersulfone-membranes-for-tear-fluid-collection
#9
Q Yang, X Liu, Z Song, L Lin, K Wu
This study evaluated the utility of polyethersulfone membranes (PESms) for tear collection and compared it with two frequently employed approaches: the use of Schirmer test paper (STP) and capillary tube (CaT). STP and PESms of 0.45 and 0.65 μm (PESm65) were examined using scanning electron microscopy (SEM), applied to soak up water and cellular lysates, and employed to collect tear fluid (TF) from rabbits. The proteins in the cellular lysates and TF were characterized through band profiling of SDS-polyacrylamide electrophoresis (PAGE) gels and Western blot analyzing...
November 1, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28990532/a-novel-scn9a-mutation-f826y-in-primary-erythromelalgia-alters-the-excitability-of-nav1-7
#10
B Wu, Y Zhang, H Tang, Mei Yang, Hai Long, Gaoxing Shi, Jianguang Tang, Xiaoliu Shi
Primary erythromelalgia (PE) is a dominant inherited disorder characterized by recurrent pain, redness, and warmth of the extremities that is caused by gain-of-function mutations in the voltage-gated sodium channel Nav1.7. We investigated a three-generation Chinese Han family with PE. The proband is a 15-year old girl presented with skin ulcers, recurrent burning pain, warmth, and redness of the lower extremities that are refractory to all kinds of reported medications. The other two patients presented with similar symptoms but with far less severity that naturally remitted near their forties...
October 9, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28429672/the-molecular-mechanisms-of-thalidomide-teratogenicity-and-implications-for-modern-medicine
#11
J Knobloch, D Jungck, A Koch
Thalidomide is a teratogen that affects many organs but primarily induces limb truncations like phocomelia. Rodents are thalidomide resistant. In the 1950s, this has led to misinterpretations of animal tests and to the fatal assumption that the drug was safe for pregnant women to use against morning sickness. The result was one of the biggest scandals in medical history: 10.000 and more infants with birth defects in Europe. Nonetheless, thalidomide still has its place in modern medicine as it has strong therapeutic potential: it has been approved by the FDA for multiple myeloma and erythema nodosum leprosum, and its anti-inflammatory, immunomodulatory and anti-angiogenic activities are considered in many other refractory diseases...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28429671/ethanolamine-metabolism-in-the-mammalian-gastrointestinal-tract-mechanisms-patterns-and-importance
#12
J Zhou, X Xiong, K Wang, L Zou, D Lv, Y Yin
Nutritional exchanges and cooperation between bacteria in the gastrointestinal tract and the mammalian host play an important role in health and disease. Ethanolamine is an essential dietary lipid nutrient for animals and is abundant in both intestinal and bacterial cell membranes. Ethanolamine can be utilized by intestinal eukaryotic cells via the cytidine phosphoethanolamine pathway for de novo synthesis of phosphatidylethanolamine, and certain bacteria are able to catabolize it as a major carbon and/or nitrogen source with the help of ethanolamine utilization proteins...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28429670/expression-of-dominant-negative-k6w-ubiquitin-in-the-lens-epithelium-via-an-adenoviral-vector-delays-posterior-capsule-opacification-in-a-rabbit-model
#13
Xuan Bao, Min Hou, Ruiping Peng, Furong Luo, Mingxing Wu
PURPOSE: Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacification (PCO) in a rabbit PCO model. METHODS: Recombinant dominant negative K6W-Ub adenovirus (RAd-K6W-Ub) with green fluorescent protein (RAd-K6W-Ub/GFP) and RAd-GFP viruses (control) were generated with QBI-HEK 293A cells...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28429669/what-can-pharmacological-models-of-retinal-degeneration-tell-us
#14
M H Reisenhofer, J Balmer, V Enzmann
Animal models with pharmacologically induced retinal degeneration including sodium iodate (NaIO3) and N-methyl-N-nitrosourea (MNU) have been extensively used in ophthalmic research to investigate retinal degeneration. NaIO3 induces degeneration of the retinal pigment epithelium (RPE) followed by photoreceptor (PRC) cell death, mimicking features of age-related macular degeneration. In contrast, MNU leads to rapid destruction of the PRCs only, enabling the use of the MNU model to investigate degeneration induced in retinitis pigmentosa...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28429668/the-role-of-mitochondria-associated-reactive-oxygen-species-in-the-amyloid-%C3%AE-induced-production-of-angiogenic-factors-by-arpe-19-cells
#15
L Wu, X Tan, L Liang, H Yu, C Wang, D Zhang, A Kijlstra, P Yang
OBJECTIVE: This study aimed to investigate the mechanisms whereby Amyloid-beta (Aβ) induces the production of angiogenic factors by a human retinal pigment epithelial cell line (ARPE-19) cells. METHODS: ARPE-19 cells obtained from the American Type Culture Collection (ATCC) were utilized in this study. The expression level of vascular endothelial growth factor (VEGF), Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and complement activation fragments C3a and C5a were measured by Real-time quantitative PCR (RT-PCR) and Enzyme-linked immunosorbent assay (ELISA)...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28231755/the-immune-function-of-ly6chi-inflammatory-monocytes-during-infection-and-inflammation
#16
L Liu, Y Wei, X Wei
Monocytes originate from progenitors in bone marrow and circulate through blood vessels and patrol the vascular endothelium or differentiate into mononuclear phagocytes and infiltrate via the bloodstream to peripheral tissues during infection and other inflammatory conditions. Recruitment of inflammatory monocytes is essential for effectively clearance of bacteria, control of Toxoplasma gondii infections and limiting tissue damage. Unexpectedly, Ly6Chiinflammatory monocytes acquire the inflammatory regulatory capacity dual phenotypes during acute infection and inflammation...
February 19, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28231754/survival-and-immunosuppression-induced-by-hepatocyte-growth-factor-in-chronic-lymphocytic-leukemia
#17
P Giannoni, G Cutrona, D de Totero
Chronic lymphocytic leukemia (CLL), the most common leukemia among adults in the western world, is characterized by a progressive accumulation of relatively mature CD5+ B cells in peripheral blood, lymph nodes and bone marrow. Despite much recent advancement in therapy, CLL is still incurable. Lymph nodes and bone marrow represent sanctuary sites preserving leukemic cells from spontaneous or drug-induced apoptosis, and infiltration of leukemic cells in these districts correlates with clinical stages and prognosis...
February 19, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28231753/prion-function-and-pathophysiology-in-non-mammalian-models
#18
N Guerrero, M M Meynard, J Borgonovo, K Palma, M L Concha, C Hetz
More than thirty years have passed since the discovery of the prion protein (PrP) and its causative role in transmissible spongiform encephalopathy. Since a combination of both gain- and loss-of-function mechanisms may underlay prion pathogenesis, understanding its physiological role may give important clues about disease mechanisms. Historically, the primary strategy for prion research has involved the use of human tissue, cell cultures and mammalian animal models. Nevertheless, experimental difficulties of in vivo studies and some controversial observations obtained in these systems have triggered the search for alternative animal models...
February 19, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28231752/decreased-hoxd10-expression-promotes-a-proliferative-and-aggressive-phenotype-in-prostate-cancer
#19
R-J Mo, J-M Lu, Y-P Wan, W Hua, Y-X Liang, Y-J Zhuo, Q-W Kuang, Y-L Liu, H-C He, W-D Zhong
HoxD10 gene plays a critical role in cell proliferation in the process of tumor development. However, the protein expression level and the function of HoxD10 in prostate cancer remain unknown. Using tissue microarray, we demonstrate that the protein expression of HoxD10 is commonly decreased in prostate cancer tissues (n = 92) compared to adjacent benign prostate tissues (n = 77). Functionally, knockdown of HoxD10 resulted in significant promotion of prostate cancer cell proliferation. Moreover, knockdown of HoxD10 strikingly stimulated prostate tumor growth in a mouse xenograft model...
February 19, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28231750/molecular-determinants-of-colon-cancer-susceptibility-in-the-east-and-west
#20
W M Abdel-Rahman, M E Faris, P Peltomäki
The currently available knowledge of factors that dictate the development and progression as well as the clinical outcome of colorectal cancers (CRC) is mainly derived from Western countries. Considerable number of publications document different incidence rates and contrasting clinical features of CRC in various groups such as the differences between urban vs. rural areas, young vs. old age and the East vs. the West. In particular, Egyptian CRC is a surprisingly young age disease with higher proportion of poorly differentiated and advanced stage cancers as compared to the Western counterparts...
February 19, 2017: Current Molecular Medicine
journal
journal
39514
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"