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Current Molecular Medicine

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https://www.readbyqxmd.com/read/30198434/seven-novel-and-three-known-mutations-in-foxl2-in-10-chinese-families-with-blepharophimosis-syndrome
#1
B Lin, B Zeng, J Zhao, T Xu, Y Wang, B Hu, F Li, Q Zhao, R Liu, J Liu, J-M Chen, D Huang, Y Wang
BACKGROUND: Blepharophimosis syndrome (BPES) is characterized by eyelid malformation with occasional premature ovarian failure. Mutations in FOXL2 underlie a fraction of BPES cases. OBJECTIVE: We aimed to investigate the genetic basis of BPES in 26 Chinese families that included 78 patients. METHOD: We performed ophthalmological examinations on each family member. We used Sanger sequencing to screen FOXL2 exons and their flanking sequences...
September 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/30198433/an-antioxidant-role-by-minocycline-via-enhancing-the-activation-of-lkb1-ampk-signaling-in-the-process-of-cerebral-ischemia-injury
#2
Z Cai, C Wang, W He, Y Chen
BACKGROUND: LKB1/AMPK signaling pathway, as a metabolic checkpoint, is involved in the pathogenesis of cerebral ischemia injury. Minocycline, a tetracycline derivative, protects against cerebral ischemia via reducing inflammation, oxidative stress, and apoptosis. The aim of the study was to evaluate the influence of minocycline on oxidative biomarkers and LKB1/AMPK signaling pathway in Wistar rats with focal cerebral ischemia injury and to clarify the neuroprotective mechanism of minocycline against focal cerebral ischemia injury...
September 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/30198432/mir-142-3p-inhibits-the-metastasis-of-hepatocellular-carcinoma-cells-by-regulating-hmgb1-gene-expression
#3
Y Fu, L-Q Sun, Y Huang, J Quan, X Hu, D Tang, R Kang, N Li, X-G Fan
BACKGROUND: Non-coding small RNAs are involved in organism development, and their aberrant regulation induces various diseases, including hepatocellular carcinoma (HCC), but their exact mechanisms have not been determined. OBJECTIVE: The aim was to investigate the role of miR-142-3p on HMGB1 expression in hepatocellular carcinoma. METHODS: Expression levels of miR-142-3p in HCC tissues and cultured cells were measured by RT-PCR. The invasion and metastasis abilities of HepG2 cells according to Transwell migration and invasion assays, and protein expression was measured by western blotting...
September 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/30198431/micrornas-in-the-intestine-role-in-renewal-homeostasis-and-inflammation
#4
L Zou, X Xiong, K Wang, Y Yin
The mammalian intestine is not only an organ for food digestion and nutrient absorption but also an integral part of the immune and endocrine systems. The intestinal epithelium under stressful environments requires epithelial cells to rapidly elicit changes in gene expression patterns to regulate their survival, adapt to stress, and maintain epithelial homeostasis. Recently, microRNAs have emerged as a novel class of post-transcriptional gene regulators that are fundamentally involved in many aspects of intestinal epithelial differentiation, architecture, and barrier function...
September 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/30198430/aging-and-proteins-what-does-proteostasis-have-to-do-with-age
#5
S Magalhaes, B J Goodfellow, A Nunes
The world is aging and we must face the challenges that this brings. One of the reasons for the increasing aging of the world's population is the increase in life expectancy and, since we live longer, it is of paramount importance to live well and to prevent age-associated diseases. In this way, it is crucial to improve knowledge of the aging process and of the mechanisms that contribute to it. Ideally it would be of great interest to have a panel of biomarkers of healthy aging that would allow an estimate of the biological age of an individual...
September 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/30051789/crocin-protects-human-umbilical-vein-endothelial-cells-from-high-glucose-induced-injury-via-inhibiting-the-endoplasmic-reticulum-stress-response
#6
H Zhang, S Wu, Y Yang, R Su, J Wen, X Ke, W Chen
BACKGROUND: Endothelial dysfunction plays a key role in diabetic atherosclerosis. High glucose (HG) is considered a stimulator in the development of diabetic atherosclerosis. The endoplasmic reticulum (ER) stress response is involved in HG-induced vascular injury. Crocin has antioxidative and antiapoptotic properties. OBJECTIVE: The current study was to evaluate whether crocin can protect human umbilical vein endothelial cells (HUVECs) from HG-induced injury and explored the associated mechanism...
July 26, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/30033867/oxidative-stress-in-cerebral-small-vessel-disease-dizziness-patients-basally-and-after-polyphenol-compound-supplementation
#7
L Ulivi, M Maccarrone, N Giannini, E Ferrari, M C Caselli, V Montano, L Chico, A Casani, E Navari, N Cerchiai, G Siciliano, U Bonuccelli, M Mancuso
Leukoaraiosis (LA) is a common radiological finding in elderly, frequently associated with several clinical disorders, including unexplained dizziness. The pathogenesis of LA is multifactorial, with a dysfunction of cerebral microcirculation resulting in chronic hypoperfusion and tissue loss, with oxidative stress involved in this cascade. The aim of this study was to analyse some oxidative stress biomarkers in a cohort of LA patients. In a subgroup of 33 patients with LA and unexplained dizziness, we have then performed an open study to evaluate if 60-day supplementation with a poliphenol compound may modify these biomarkers and influence quality of life, analysed with the Dizziness handicap Inventory (DHI) scale...
July 20, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29437010/neuronal-expression-of-junctional-adhesion-molecule-c-is-essential-for-retinal-thickness-and-photoreceptor-survival
#8
Y Li, F Zhang, W Lu, X Li
BACKGROUND: Photoreceptor cell death is a key pathology of retinal degeneration diseases. To date, the molecular mechanisms for this pathological process remain largely unclear. Junctional adhesion molecule-c (Jam-c) has been shown to play important roles in different biological events. However, its effect on retinal neuronal cells is unknown. OBJECTIVE: To determine the effect of Jam-c on adult mouse eyes, particularly, on retinal structure, vasculature and photoreceptor cells, in order to explore potential important target molecules for ocular diseases...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29437009/the-bhlh-protein-nulp1-is-essential-for-femur-development-via-acting-as-a-cofactor-in-wnt-signaling-in-drosophila
#9
Q Zeng, Y Wan, P Zhu, M Zhao, F Jiang, J Chen, M Tang, X Zhu, Y Li, H Zha, Y Wang, M Hu, X Mo, Y Zhang, Y Chen, Y Chen, X Ye, R Bodmer, K Ocorr, Z Jiang, J Zhuang, W Yuan, X Wu
BACKGROUND: The basic helix-loop-helix (bHLH) protein families are a large class of transcription factors, which are associated with cell proliferation, tissue differentiation, and other important development processes. We reported that the Nuclear localized protein-1 (Nulp1) might act as a novel bHLH transcriptional factor to mediate cellular functions. However, its role in development in vivo remains unknown. METHODS: Nulp1 (dNulp1) mutants are generated by CRISPR/Cas9 targeting the Domain of Unknown Function (DUF654) in its C terminal...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29437008/identification-of-a-good-prognosis-idh-mutant-like-population-of-patients-with-diffuse-gliomas
#10
Z Wang, X Liu, Z Wang, Z Bao, W Zhang, C Zhang, T Jiang
BACKGROUND: Isocitrate dehydrogenase (IDH) mutation is the initiating event that defines major clinical and prognostic classes of gliomas, but the potential mechanisms have not been well interpreted yet. The main objective of the current study was to better understand the underlying biology of IDH mutant gliomas as captured by gene expression profiles. METHODS: RNA sequencing data of WHO grade II-IV gliomas from the Chinese Glioma Genome Atlas (CGGA, N=325) were used to assess differentially expressed genes between IDH mutant and wild type gliomas and to construct a gene expression-based classifier to detect IDH mutant samples with high sensitivity and specificity...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29424313/mesenchymal-stem-cells-inhibited-dendritic-cells-via-the-regulation-of-stat1-and-stat6-phosphorylation-in-experimental-autoimmune-uveitis
#11
L Dong, X Chen, H Shao, L Bai, X Li, X Zhang
PURPOSE: We have previously reported that MSCs inhibited experimental autoimmune uveitis (EAU) in rodent models induced by either uveitogenic antigens or antigen-specific T cells. In this study, we explored the inhibitory mechanisms of MSCs on dendritic cells (DCs) in EAU. METHODS: We collected the DCs from the lymph nodes of MSC treated or untreated EAU rats, as well as bone marrow derived DCs cultured in vitro with or without MSC treatment. The levels of costimulatory molecules of CD80, CD86, CD40, OX40L and suppressors of cytokine signaling (SOCS1, SOCS2, and SOCS3) on these DCs were analyzed by flow Cytometry...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29424312/association-of-il33-and-il1rap-polymorphisms-with-acute-anterior-uveitis
#12
X-F Huang, W Chi, D Lin, M-L Dai, Y-L Wang, Y-M Yang, Z-B Jin, Y Wang
BACKGROUND: AAU (acute anterior uveitis) is the most common entity of uveitis characterized by acute vision loss and violent sore eyes. IL-33 and IL-1RacP have been found to play crucial roles in the innate immune system. OBJECTIVE: In the present study, we investigated the association of IL33 and IL1RAP genes with AAU. METHOD: A total of 549 AAU patients and 1080 unrelated healthy controls were recruited for this study. Ten single nucleotide polymorphisms (SNPs) were genotyped using Sequenom Mass ARRAY technology...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29424311/how-to-deal-with-uveitis-patients
#13
P Yang, L Du, Z Ye
During the past nine years, our center has grown into the largest uveitis referral center in China. To deal with this increasing stream of patients we have developed a management system to coordinate communication with our patients, their referring ophthalmologists, consultations with other medical specialties and worldrenowned foreign uveitis specialists. We have established the biggest database of uveitis patients records allowing continuous analysis of clinical features and response to treatment of patients with various uveitis entities as well as the evaluation of the relevance of various ancillary tests performed in this patient group...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29424310/elevated-interleukin-37-expression-associated-with-disease-activity-in-hla-b27-associated-anterior-uveitis-and-idiopathic-anterior-uveitis
#14
B Zhao, S Zhang, W Chen, R Zhang, R Jiang, R Zhang, L Chen
BACKGROUND & OBJECTIVE: Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS: 15 patients with HLA-B27-associated AAU, 10 patients with idiopathic AAU and 22 controls were recruited to this study from August 2013 to December 2016...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29424309/editorial-uveitis-pathology-molecular-mechanisms-and-therapy
#15
EDITORIAL
Peizeng Yang
No abstract text is available yet for this article.
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29256352/puerarin-stimulates-osteogenic-differentiation-and-bone-formation-through-the-erk1-2-and-p38-mapk-signaling-pathways
#16
X Yang, Y Yang, S Zhou, X Gong, Q Dai, P Zhang, L Jiang
BACKGROUND: Osteoporosis is a world-wide health problem, which leads to decreased bone strength and increased susceptibility to fractures. Puerarin, a phytoestrogen extracted from Pueraria lobata (Willd.) Ohwi, has been identified as a promising intervention for preventing bone loss and promoting bone regeneration. However, the underlying mechanisms for its anabolic action are still not clear. In the present study, we aimed to investigate the effect of puerarin on the osteogenic differentiation of bone marrow stromal cells (BMSCs) and the possible molecular mechanism mediating its action...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/30033868/polyreactive-antibodies-in-anti-hiv-1-responses
#17
H Liao, Z Zhang
In order to combat the vast array of infectious agents it may encounter, the adaptive immune system develops a tremendously diversified antibody repertoire. B cells expressing polyreactive or autoreactive antibodies are eliminated through multiple checkpoints during early B cell development. Defects in any of these checkpoints may lead to the production of polyreactive or autoreactive antibodies, and cause autoimmune diseases. However, recent studies on a panel of established HIV-1-neutralizing antibodies and a large collection of recombinant anti-gp160 antibodies derived from HIV- 1-infected individuals showed that many of these antibodies are polyreactive or autoreactive...
2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29974831/decreased-expression-of-mypt1-contributes-to-tumor-angiogenesis-and-poor-patient-prognosis-in-human-prostate-cancer
#18
Y Liang, Y Zhuo, Z Lin, F Jiang, Q Dai, J Lu, W Dong, X Zhu, Z Han, W Zhong
BACKGROUND: Our previous study demonstrated that Myosin Phosphatase Targeting subunit 1 (MYPT1) may function as a direct target of microRNA-30d, which promotes tumor angiogenesis and tumor growth of prostate cancer (PCa). Here, we aimed to investigate the clinical significance of MYPT1 expression and its functions in PCa. METHODS: Roles of MYPT1 deregulation in tumor angiogenesis of PCa was determined in vitro and in vivo experiments. Expression patterns of MYPT1 and CD31 proteins were examined by immunohistochemistry and immunofluorescence, respectively...
2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29974830/adipokine-visfatin-s-role-in-pathogenesis-of-diabesity-and-related-metabolic-derangements
#19
B Kumari, U C S Yadav
Visfatin is one of the prominent adipokines secreted by adipose tissue. The level of visfatin increases significantly in persons with obesity owing to increased body mass index (BMI). During obesity, the adipocytes, which populate adipose tissue, undergo hypertrophy and hyperplasia and secrete a number of adipocytokines including visfatin. Visfatin, which also acts as an enzyme nicotinamide phosphoribosyl transferase, is one of the prominent adipokines that influence metabolic homeostasis in the body. Visfatin exists in two forms, extracellular and intracellular, and enacts a multitude of actions...
2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29974829/znf424-induces-apoptosis-and-inhibits-proliferation-in-lung-carcinoma-cells
#20
W Liu, W Yuan, X Li, J Zhuang, X Mo, G Dai, Y Wang, J Chen, Y Wan, Y Li, X Zhu, Y Chen, S Luo, Z Jiang, Y Shi, F Chen, L Cao, X Ye, X Fan, P Zhu, K Zhang, X Wu
BACKGROUND: Previously, we showed that the Zinc finger-containing transcription factor ZNF424 inhibits p21 transcription, which has been widely associated with various cancers. However, because the roles of ZNF424 in tumorigenesis have not been characterized, we correlated ZNF424 expression with tumorigenesis in lung cancer. RESULTS: The present immunohistochemical analyses show significantly lower ZNF424 expression levels in 43 of 60 lung cancer tissues compared with adjacent tissues...
2018: Current Molecular Medicine
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