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Current Molecular Medicine

S Sun, Y Wang, H Chen, L Fang, Y Cui, X Han, D Wu, H Li, M Ye, X Zhao, J Liu
BACKGROUND: Sip1/Tuftelin Interacting Protein (STIP) is highly conserved from Caenorhabditis elegans to Homo sapiens and has essential biological functions. However, its function in leukemia remains unknown. METHODS: Clinic Samples and cell model were used in this article to investigate the expression of STIP in lymphoblastic leukemia. The functional research of STIP was performed in ARH-77 by siRNA transfection, Immunofluorescence, cell count, cell cycle analysis, quantitative real-time RT-PCR, Sub-cellular Fractionation assays, Immunoprecipitation and Western blotting...
October 18, 2016: Current Molecular Medicine
H Hu, H Liu, C Peng, T Deng, X Fu, C Chung, E Zhang, C Lu, K Zhang, Z Liang, Y Yang
OBJECTIVES: To detect trisomy 21, 18, and 13 in 190,277 clinical samples from the medical diagnostic laboratories of ten hospitals. METHODS: The study assessed the clinical performance of non-invasive prenatal testing (NIPT) in detecting trisomy 21, 18, and 13 in 190,277 clinical samples using semiconductor sequencing technology. RESULTS: NIPT participants were at a mean gestation of 17.79 weeks (range, 9-36) and age of 31.12 years (range, 18-46) at the time of testing in average...
October 13, 2016: Current Molecular Medicine
M Maida, F S Macaluso, F Salomone, S Petta
NAFLD (Non-Alcoholic Fatty Liver Disease) is an increasingly significant public health issue, regarded as the most relevant liver disease of the twenty-first century. Approximately 20%-30% of NAFLD subjects develop a NASH (Non-Alcoholic Steato-Hepatitis), a condition which can potentially evolve to liver cirrhosis and hepatocellular carcinoma. For these reasons a proper evaluation of liver damage is a key point for diagnosis and prognosis and liver biopsy still remains the "gold standard" procedure both for discrimination between steatosis and steatohepatitis and assessment of the degree of liver fibrosis...
October 4, 2016: Current Molecular Medicine
T Han, H Hu, M Zhuo, L Wang, J-J Cui, F Jiao, L-W Wang
Pancreatic cancer remains a worldwide issue and burden that is hard to resolve given its low resection rate and chemo-resistance. Early diagnosis and early treatment are critical for conquering pancreatic cancer. Therefore, new biomarkers for diagnosis and prognosis are urgently needed. Previously, researchers mainly focused on protein-coding genetic and epigenetic changes in many types of cancers, and regarded the non-coding part as waste. Recently, however, long non-coding RNA (lncRNA) has emerged as a major participant in carcinogenesis, as it regulates cell proliferation, migration, invasion, metastasis, chemo-resistance, etc...
September 26, 2016: Current Molecular Medicine
S Cheng, W Y So, D Zhang, Q Cheng, B J Boucher, P S Leung
OBJECTIVES: The present study was designed to investigate the effects of calcitriol (the active hormonal metabolite of vitamin D) on hepatic metabolic abnormalities in type 2 diabetes. METHODS: Type 2 diabetic db/db mice were used to investigate the effects of calcitriol on hepatic and systemic metabolic disorders. HepG2 cells cultured in insulin-resistant conditions were used to examine the potential mechanisms for calcitriol-induced changes in hepatic lipid and glucose metabolism...
September 20, 2016: Current Molecular Medicine
D Nayak, R Rasool, S Chakraborty, A Katoch, H Amin, B Rah, A Goswami
The incitement of unfolded protein response (UPR) during endoplasmic reticulum (ER) stress by diverse intracellular (hypoxia, nutrient deprivation, etc.) or extracellular (environmental or drug induced) stimuli is considered a major threat for perturbing cellular homeostasis leading to gathering of unfolded proteins inside the cell. The catastrophic UPR events emerge as a foremost cellular adaptation by remodeling cancer cell signaling and restoring ER homeostasis in favor of tumor growth. The transient ER stress protects cancer cells from undergoing apoptosis, whereas the prolonged stress response further activates a number of cell death pathways...
August 29, 2016: Current Molecular Medicine
Y Wang, P Xu, L Qiu, M Zhang, Y Huang, J C Zheng
Cell cycle regulation of neural progenitor cells (NPCs) is an essential process for neurogenesis, neural development, and repair after brain trauma. Stromal cell-derived factor-1 (SDF-1, CXCL12) with its receptors CXCR4 and CXCR7 are well known in regulating the proliferation and survival of NPCs. The effects of CXCL12 on NPCs cell cycle and its associated signaling pathways remain unclear. The cell cycle regulation protein, Cyclin D1, a downstream target of β-catenin, is critical for cell cycle control and may play an important role in NPCs proliferation...
August 29, 2016: Current Molecular Medicine
Z Huang, J-W Xiang, L Zhou, Q Nie, L Wang, Z Chen, X-H Hu, Y Xiao, W-J Qing, Y-F Liu, Q Sun, X-C Tang, F-Y Liu, Z-W Luo, W-B Liu, D W-C Li
The male abnormal gene family contains 3 members, named mab21l1, mab21l2 and mab21l3. Since their first discovery in C. elegans, homologues of mab21l1 and mab21l2 have been found in Drosophila, Zebrafish, Xenopus, chicken, mouse and human. A number of studies have revealed that mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. Here, we review the functions of the mab genes in regulating ocular development.
August 24, 2016: Current Molecular Medicine
A Micera, B O Balzamino, F Biamonte, G Esposito, R Marino, F Fanelli, F Keller
Reelin is a matrix glycoprotein that plays a pivotal role for the positioning of neurons throughout brain development. In the early developing cortex Reelin regulates radial migration of cortical neurons while later in development, Reelin promotes maturation of dendrites and dendritic spines. Low Reelin levels characterize healthy adult brain while increased Reelin levels have been associated with cellular events underlying response to injury. Reelin has been detected in structural and immune cells outside brain (liver, gut/colon tracts, kidney, testis, ovary, lung, retina and cornea)...
August 5, 2016: Current Molecular Medicine
E G de Lima, C M M do Amaral, F C Q Peixe, A P A D Gurgel, J da Costa Silva Neto, A C de Freitas
Breast cancer is the most common cancer in women worldwide. Several studies have demonstrated the presence of Human papillomavirus (HPV) DNA in breast cancer samples. However, the role of HPV in breast carcinogenesis is not clear, and the interaction mechanisms between this infectious agent and the breast cancer cell need to be more fully clarified. In this article, we discuss the putative roles of HPV infection in breast carcinogenesis.
August 5, 2016: Current Molecular Medicine
W-Y Wang, Y Chen, X Su, D Tang, Q-W Ben, W-Y Yao, P Chen, Y-Z Yuan
BACKGROUND: Resistin-like molecule-α (RELMα) has diverse regulatory functions in inflammation, but its role in severe acute pancreatitis (SAP) and acute pancreatitis associated lung injury (APALI) remains unclear. METHODS: SAP was induced in rats. RELMα protein expression was detected in lung tissue of rats to determine the relationship between APALI and RELMα. To investigate the effect of RELMα overexpression or knockdown on APALI, rats were given an intravenous injection of adenovirus vector before SAP induction...
August 2, 2016: Current Molecular Medicine
A M S Silva, S Correia, S Socorro, C J Maia
The testes are one of the most delicate organs in the male body and highly susceptible to the exogenous influences capable of inducing cell damage. Cancer therapies are well known to negatively affect the male reproductive tract with a severe impairment of spermatogenesis and infertility. The present work aimed to systematically review the available information about the different endogenous factors (hormonal and non-hormonal) that may have protective or advantageous properties on the recovery of male reproductive function after gonadal injury...
August 2, 2016: Current Molecular Medicine
F Zhu, Y Guan, R Zhang
BACKGROUND: Linoleic acid has been implicated in the pathogenesis of acute pancreatitis. However, molecular mechanisms underlying adverse effects of large-dose linoleic acid remain unclear. Current study aimed to explore the impact of high-dose linoleic acid on the activation of Janus kinase 2 (JAK2)-signal transducers and activators of transcription 3 (STAT3) pathway, cytokine production, and lipogenesis in pancreatic exocrine cells. METHODS: MTT assay was used to detect the viability of AR42J rat pancreatic exocrine cells, and lactate dehydrogenase assay was utilized to detect cytotoxicity...
July 21, 2016: Current Molecular Medicine
C V Vaz, S Correia, H J Cardoso, M I Figueira, R Marques, C J Maia, S Socorro
Regucalcin (RGN) is a multifunctional protein that was first described as a calcium (Ca2+)-binding protein playing a relevant role in the maintenance of intracellular Ca2+ concentration. However, due to its downregulated expression with aging, RGN is also known as senescence marker protein-30. The RGN protein is an X-chromosome gene product, whose transcription is regulated by a myriad of hormonal and non-hormonal factors. Besides the well-known role in Ca2+ homeostasis, RGN has also been linked to the control of several intracellular signaling pathways, and basic biological processes, such as oxidative stress, cell proliferation, apoptosis, and metabolism...
July 14, 2016: Current Molecular Medicine
F Fahs, X-L Bi, F-S Yu, L Zhou, Q-S Mi
Skin and corneal wounds in diabetics are a major healthcare burden. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate the expression of protein-coding genes. Studies have identified microRNAs involved in all phases of wound healing. The dysregulation of microRNAs can contribute to impaired or delayed skin and corneal wound healing in diabetics. Here, we present a comprehensive review of the literature involving microRNAs in diabetic skin and corneal wound healing as well as those serving as potential biomarkers for diabetic wound healing...
June 6, 2016: Current Molecular Medicine
M Rodriguez, S Siwko, M Liu
Prostate cancer is highly prevalent among men in developed countries, but a significant proportion of detected cancers remain indolent, never progressing into aggressive carcinomas. This highlights the need to develop refined biomarkers that can distinguish between indolent and potentially dangerous cases. The prostate-specific G-protein coupled receptor (PSGR, or OR51E2) is an olfactory receptor family member with highly specific expression in human prostate epithelium that is highly overexpressed in PIN and prostate cancer...
2016: Current Molecular Medicine
Z Jiang, F Li, Y Wan, Z Han, W Yuan, L Cao, Y Deng, X Peng, F Chen, X Fan, X Liu, G Dai, Y Wang, Q Zeng, Y Shi, Z Zhou, Y Chen, W Xu, S Luo, S Chen, X Ye, X Mo, X Wu, Y Li
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. However, its precise role is not yet well understood. A yeast two-hybrid screen was performed using a human cDNA library to identify potential LASS5- interaction partners. One identified clone encodes succinate dehydrogenase subunit B (SDHB). Mammalian two-hybrid assays showed that LASS5 interacts with SDHB, and the result was also confirmed by GST pull-down and coimmunoprecipitation assays...
2016: Current Molecular Medicine
Z Li, J Wang, F Gao, J Zhang, H Tian, X Shi, C Lian, Y Sun, W Li, J-Y Xu, P Li, J Zhang, Z Gao, J Xu, F Wang, L Lu, G-T Xu
UNLABELLED: Stem cell therapy is a promising therapeutic approach for retinal degeneration (RD). Our study investigated the effects of human adipose derived stem cell (hADSCs) on Royal College of Surgeons (RCS) rats. METHODS: Green fluorescent protein (GFP)-labeled hADSCs were transplanted subretinally into RCS rats at postnatal (PN) 21 days to explore potential therapeutic effects, while adeno-associated viral vector (AAV2)-vascular endothelial growth factor (VEGF) and siVEGF-hADSCs were used to aid the mechanistic dissections...
2016: Current Molecular Medicine
P Li, H Tian, Z Li, L Wang, F Gao, Q Ou, C Lian, W Li, C Jin, J Zhang, J-Y Xu, J Wang, J Zhang, F Wang, L Lu, G-T Xu
Bone marrow mesenchymal stem cells (BMSCs) have a therapeutic role in retinal degeneration (RD). However, heterogeneity of BMSCs may be associated with differential therapeutic effects in RD. In order to confirm this hypothesis, two subsets of rat BMSCs, termed rBMSC1 and rBMSC2, were obtained, characterized and functionally evaluated in the treatment of RD of Royal College of Surgeons (RCS) rats. Both subpopulations expressed mesenchymal stem cells (MSC) markers CD29 and CD90, but were negative for hemacyte antigen CD11b and CD45 expression...
2016: Current Molecular Medicine
W Chu, J Cheng, X Zhu, P Wu, L Chen, J Wang, Y Wu, M Zeng, J Zhang
Follistatin-related protein (FSRP), which belongs to a member of the follistatin family, has been postulated to be a new negative regulator of myostatin (MSTN) and is involved in muscle development. In this study, we cloned the complete cDNA sequence of FSRP-1 from Chinese perch muscle. FSRP-1 mRNA was highly expressed in the fast muscle and brain tissue of adult fish. The expression of FSRP-1 rapidly increased at 90 days post hatching (dph) in the fast muscle of Chinese perch. Furthermore, to investigate the roles of FSRP-1 in muscle growth, we constructed a FSRP- 1 expression vector and isolated FSRP-1 fusion protein...
2016: Current Molecular Medicine
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