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Internal Medicine Journal

Karn Wijarnpreecha, Charat Thongprayoon, Natanong Thamcharoen, Panadeekarn Panjawatanan, Wisit Cheungpasitporn
BACKGROUND/OBJECTIVES: The risk of renal cell carcinoma (RCC) in individuals who regularly drink coffee is controversial. Several antioxidant compounds in coffee have been proposed to reduce the risk of RCC, while the findings from several studies raise concerns regarding a potential increased risk of RCC with coffee consumption. The aim of this meta-analysis was to evaluate the association between coffee consumption and RCC. METHODS: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception until December 2016...
September 11, 2017: Internal Medicine Journal
Ping-Song Chou, Wei-Pin Chang, Yii-Her Chou
BACKGROUND: Epidemiological studies have reported an association between urolithiasis and cardiovascular disease. However, studies examining the risks of ischemic and hemorrhagic stroke in patients with urolithiasis are limited. AIMS AND METHODS: By using a nationwide population database, we conducted a matched cohort study to investigate the association between urolithiasis and longitudinal risks of ischemic and hemorrhagic stroke. RESULTS: A total of 12,979 and 64,895 patients were included in the urolithiasis and nonurolithiasis cohorts, respectively...
September 11, 2017: Internal Medicine Journal
Syed Zujajuddin Quadri, Thang Huynh, Cecilia Cappelen-Smith, Nirupama Wijesuriya, Abul Mamun, Roy Beran, Alan Mcdougall, Dennis Cordato
BACKGROUND: The benefit of palliative care referral for severe stroke patients on end-of-life care pathways (EOLCP) is increasingly recognised. Palliative care provides assistance with symptom management and transition to end-of-life care. Advance care planning (ACP) may help accommodate patient/family expectations and guide management. METHOD: Retrospective study of all stroke deaths (2014-2015) at Liverpool Hospital, Sydney, Australia. Data examined included age, co-morbidities, living arrangements, pre-existing ACP, palliative care referral rates and 'survival time'...
September 11, 2017: Internal Medicine Journal
Nathan J Elgar, Brian J Smith
BACKGROUND: Medical fitness to drive is one way governments control the issuing and renewal of driving licences and some jurisdictions demand mandatory reporting of unsafe drivers by doctors. AIM: We wished to determine the views, adherence rate and experiences of sleep physicians and electro-physicians with regard to South Australia's mandatory reporting law. METHODS: Self-administered surveys were delivered by post and e-mail to all South Australian Medical Board registered sleep physicians (n=49) and electro-physicians (n=11)...
September 11, 2017: Internal Medicine Journal
Edmond Ang, Los Vincent Newton
BACKGROUND: Systemic Anticancer Treatment (SACT) at the end of life is considered poor practice due to futility and associated toxicities. Consequently, 30-Day Mortality after SACT is increasingly recognised as a potential real world quality of care indicator in medical oncology. AIMS: Whangarei Base Hospital (WBH) provides outpatient SACT treatment to all patients living in the Northland region of New Zealand. The goal of this study is to report our 30 Day mortality after SACT and to contribute to the experience of its use in Australasia...
September 5, 2017: Internal Medicine Journal
Caitlin Murphy, Violet Mukaro, Robert Tobler, Rebecca Asher, Emma Gibbs, Linda West, Bruno Giuffre, Sally Baron-Hay, Mustafa Khasraw
BACKGROUND: Magnetic Resonance Imaging (MRI) accuracy after neoadjuvant systemic therapy (NST) for breast cancer varies according to hormone receptor (HR), human epidermal growth factor receptor type-2 (HER2) subtype and Ki67 proliferation index. Whether MRI accuracy varies by genomic signatures is unknown. We examined accuracy of MRI in the NEONAB trial ( #: NCT01830244). METHODS: Patients with stage II-III breast cancer received sequential epirubicin, cyclophosphamide and nab-paclitaxel and trastuzumab if HER2+...
September 4, 2017: Internal Medicine Journal
Frank S Hong, Nicole Sieradzki, Claire Pollock, Faye Nasra, Allison Mo, Abbey Willcox, Leonid Churilov, Wai Khoon Ho, Carole Smith
BACKGROUND: Preoperative anaemia is associated with increased morbidity and mortality in surgical patients. Recent national patient blood management guideline recommended screening surgical patients for anaemia and in particular iron deficiency anaemia, without reference to the prevalence of anaemia or iron deficiency anaemia in this patient population. AIMS: To establish the prevalence and cause of preoperative anaemia in elective major surgery patients. METHODS: Patients attending the anaesthetic pre-admission clinics from 1 July 2013 to 30 June 2014 prior to their major elective surgery in our institution were screened for anaemia and iron deficiency by measuring full blood count, iron studies and C-reactive protein...
September 4, 2017: Internal Medicine Journal
Ki Ryang Na, Yoo Hyung Kim, Hyo Kyun Chung, Min-Kyung Yeo, Young Rok Ham, Jin Young Jeong, Koon Soon Kim, Kang Wook Lee, Dae Eun Choi
BACKGROUND: Growth differentiation factor 15 (GDF 15) has recently been reported as a useful prognostic marker in patients with chronic inflammatory disease and heart disease. AIM: Our aim of this study is evaluating the role of GDF 15 as a potential predictor of renal outcome in immunoglobulin A nephropathy (IgAN). METHODS: 212 patients in the Chungnam National Hospital glomerulonephritis cohort, who were diagnosed as biopsy-proven IgAN from March 2010 to June 2014, were included...
September 4, 2017: Internal Medicine Journal
Anam Kamran, Elisa Chia, Claire Tobin
BACKGROUND: Oxygen is a widely used drug in the hospital setting. However, international audits suggest that oxygen administration practices are often not compliant with prescribed standards. This can place patients at risk and cause serious adverse events. AIM: To analyse data related to recent practices of oxygen prescription and administration at Royal Perth Hospital (RPH), Western Australia. The results of this audit aim to guide further research on possible interventional studies implementing key solutions...
September 4, 2017: Internal Medicine Journal
James D Stewart, Naomi Runnegar
BACKGROUND: Management of Staphylococcus aureus bacteraemia (SAB) includes prolonged intravenous antibiotics often via a peripherally inserted central catheter (PICC). Optimal timing of PICC insertion for SAB treatment is unknown. There are concerns that early insertion may increase the risk of subsequent line infection. AIMS: This retrospective audit aims to determine if early PICC insertion is safe. The outcomes considered included crude mortality, attributable mortality, PICC line infections, duration of bacteraemia and relapsed SAB...
September 4, 2017: Internal Medicine Journal
Marco Matteo Ciccone, Giuseppe Loverro, Pietro Scicchitano, Matteo Loverro, Gabriella Ricci, Francesca Scaramuzzi, Michele Gesualdo, Annapaola Zito, Marcello Campagna, Michele Moncelli, Vittorio Nicolardi, Fabio Manca, Barbara Boninfante, Santa Carbonara, Francesca Cortese, Orlando Todarello, Carlo Bettocchi
INTRODUCTION: The aim was to evaluate and stratify early cardiovascular risk of transsexuals undergone pharmacological and/or surgical gender reassignment. METHODS: Fifty-six transsexuals were divided into two groups: 1- undergone gonadectomy (orchiectomy for trans women and hystero-annessiectomy for trans men); group 2- hormone replacement therapy alone. All underwent carotid artery intima-media thickness (C-IMT) and flow-mediated vasodilation (FMD) of brachial artery evaluations...
August 30, 2017: Internal Medicine Journal
Scott A Harding, Ana Holley, Ben Wilkins, Sarah Fairley, Mark Simmonds, Peter D Larsen
BACKGROUND: We studied clinical outcomes and discontinuation rates in a "real world" population presenting with myocardial infarction treated with ticagrelor or clopidogrel. METHODS: Between January 2012 and May 2015, 992 patients with acute myocardial infarction undergoing invasive management and adequately pre-treated with dual antiplatelet therapy were prospectively enrolled. Platelet aggregation was measured using the Multiplate analyser. Baseline characteristics, in-hospital outcomes and 1 year outcomes were collected...
August 30, 2017: Internal Medicine Journal
Anver Sethwala, Xiaojie Wang, Emma E Sturm, Kate L Collins, Ronan O'Donnabhain, N Deborah Friedman
BACKGROUND: Pulmonary embolism (PE) is associated with significant morbidity and mortality. PE is a heterogeneous entity causing a wide variety of clinical presentations, making it imperative to establish which clinical symptoms, signs and biomarkers can influence the pre-test probability of PE to aid clinicians and reduce over testing. AIMS: The objective of this study was to analyse the clinical parameters used by clinicians to order a Computer Tomography Pulmonary Angiogram (CTPA), and establish which were associated with the presence of PE...
August 30, 2017: Internal Medicine Journal
Andrew J Burke, Karen Hay, Alex Chadwick, Dan Siskind, Judith Sheridan
BACKGROUND: People with severe mental illness (SMI) have a lower life expectancy in part due to a higher prevalence of cardiac and metabolic disease. Less is known of the prevalence of respiratory disease in this group. AIMS: This cross sectional, observational study aimed to assess the prevalence of symptoms associated with respiratory disease in patients admitted to an inpatient mental health unit. METHODS: A convenience sample of eighty-two inpatients had a structured interview and questionnaire completed...
August 30, 2017: Internal Medicine Journal
Glenna Gibson, Aravind Ravi Kumar, Karin Steinke, Farzad Bashirzadeh, Rebecca Roach, Morgan Windsor, Robert Ware, David Fielding
BACKGROUND: Clinical prediction models and 18F-FDG-PET/CT are used for assessment of solitary pulmonary nodules (SPNs) however biopsy is still required before treatment which carries risk. AIM: To determine combined predictive benefit of one such model combined with modern PET/CT data to improve decision making about biopsy prior to treatment and possibly reduce costs. METHOD: Patients with a SPN undergoing 18F-FDG-PET/CT from January 2011-December 2012 were retrospectively identified...
August 7, 2017: Internal Medicine Journal
Michelle Claudine Woolley, Simon Stebbings, John Highton
AIMS: To review incident cases of statin-associated immune mediated necrotising myopathy (IMNM) associated with anti-HMGCR antibodies in a single New Zealand centre, over a two year period. METHODS: Four incident cases of statin-associated IMNM were seen between 2014 and 2016. Their presentation, investigation, treatment and current response to treatment are summarised. Two of the four patients were Pacific Islanders despite a small pacific island population in the southern district health board (SDHB)...
August 7, 2017: Internal Medicine Journal
Alesha A Thai, Mark Tacey, Amanda Byrne, Shane White, Jaclyn Yoong
BACKGROUND: Globally, racial and ethnic disparities exist in treatments and outcomes for cancer patients. In Australia, there is little published data relating to cancer patients from culturally and linguistically diverse (CALD) backgrounds. AIM: To explore disparities in adjuvant chemotherapy utilisation in cancer patients from CALD groups. METHODS: Retrospective analysis of patients who were recommended adjuvant chemotherapy for early-stage breast cancer (eBC) or early-stage colorectal cancer (eCRC) between July 2011 and October 2014...
August 1, 2017: Internal Medicine Journal
Jane Rigg, Kimberley Irwin, Fred Tremayne, David Reutens
OBJECTIVES: Prone position has been identified as an important risk factor for Sudden Unexpected Death in Epilepsy (SUDEP) raising the possibility of avoidance of this posture in sleep as a preventative measure. To evaluate the potential utility of such postural measures, we studied patterns of postural change during generalised tonic clonic seizures (GTCSs). METHODS: Video electroencephalographic (video-EEG) recordings for patients undergoing investigations at the Royal Brisbane and Women's Hospital between 2005 and 2013 were reviewed independently by two raters...
August 1, 2017: Internal Medicine Journal
Nashringi Weir, Amanda Fischer, Phillip Good
BACKGROUND: There is little research and no clear guidelines for clinicians to follow when instructing patients with advanced disease about driving. AIMS: To investigate current practice in providing advice to patients with advanced disease and identify areas of consensus or variation with the Australian driving guidelines. METHODS: An online survey was distributed to Australian members of the Australian and New Zealand Society of Palliative Medicine (ANZSPM)...
August 1, 2017: Internal Medicine Journal
P N Ding, T L Roberts, W Chua, T M Becker, J Descallar, P Y Yip, V J Bray
AIMS: We aim to describe clinical characteristics, treatment patterns and factors influencing outcomes in patients with EGFR-mutated non-small cell lung cancer (NSCLC) in SWSLHD. METHODS: Retrospective review of patients with EGFR-mutated NSCLC diagnosed between January 2010 and June 2016. RESULTS: A total of 85 EGFR-mutated NSCLC patients were identified; 80 (94%) received first line treatment with EGFR-TKI. The median follow-up was 10.7 months with a median duration of treatment of 9 months...
July 25, 2017: Internal Medicine Journal
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