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Internal Medicine Journal

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https://www.readbyqxmd.com/read/29761614/diagnostic-value-of-nailfold-videocapillaroscopy-in-systemic-sclerosis-secondary-pulmonary-arterial-hypertension-a-meta-analysis
#1
Zhongbin Xia, Guiping Wang, Huashi Xiao, Shanshan Guo, Ying Liu, Fanru Meng, Dan Liu, Guoqing Li, Liang Zong
BACKGROUND: Microvascular changes play a decisive role in systemic sclerosis (SSc) and occur early in the course of the disease. Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of the vascular changes in SSc, and the abnormal changes especially capillary density and capillary width are detectable at nailfold videocapillaroscopy (NVC). AIM: The aim of this meta-analysis was to investigate the differences in capillary nailfold changes in SSc patients with and without PAH, and to estimate the early diagnostic value of NVC in systemic sclerosis secondary pulmonary arterial hypertension (SSc-PAH)...
May 15, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29761620/polyserositis-a-diagnostic-challenge
#2
Inés Losada, Juan González Moreno, Nuria Roda, Lola Ventayol, Yolanda Borjas, Francisco Javier Domínguez, Victoria Fernández Vaca, Mercedes García Gasalla, Antoni Payeras
Polyserositis (PS) is the inflammation, with effusion, of different serous membranes. It has been associated with different aetiologiesbut the aetiology of PS remains unknown in a high percentage of patients. The general objective of this retrospective study was to analyse the aetiology of PS cases seen at Son Llàtzer Hospital in an eleven-year period. Other objectives were to determine epidemiological, clinical, and analytical characteristics of these patients. Ninety-two patients were included in the study...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29761611/multidisciplinary-team-meetings-appear-to-be-effective-in-inflammatory-bowel-disease-management-an-audit-of-process-and-outcomes
#3
Mutaz Ferman, Amanda H Lim, Monowar Hossain, Glenn W Siow, Jane M Andrews
BACKGROUND: Multidisciplinary team meetings (MDTMs) have proven efficacy in cancer management. Whilst widely implemented in inflammatory bowel disease (IBD) care, their value is yet to be investigated. We reviewed the performance of MDTMs for IBD patients. METHODS: Retrospective review of MDTMs from March 2013 to July 2016. Each patient's first MDTM was considered. Data collected included: report production and location, disease factors, recommendation(s), implementation and barriers to implementation...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29761607/epidemiology-and-phylogenetic-analysis-of-hepatitis-d-virus-infection-in-australia
#4
Kathy Jackson, Jennifer MacLachlan, Benjamin Cowie, Stephen Locarnini, D Scott Bowden, Nasra Higgins, Theo Karapanagiotidis, Suellen Nicholson, Margaret Littlejohn
BACKGROUND: The incidence and trends in hepatitis D virus (HDV) in Australia have not been recently assessed and the circulating genotypes have never been determined. AIM: This study aimed to characterise the current virology and epidemiology of HDV. METHODS: Notifiable disease surveillance and laboratory testing data were analysed to assess demographics, risk factors, and trends. HDV serology and RNA testing were performed on requested samples from 2010-2016...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29756282/acute-arthritis-predictive-factors-and-current-practice-in-the-approach-to-diagnosis-and-management-across-two-hospitals-in-sydney
#5
Katrina Pavic, Jay Pandya, Sophie Sebak, Amith Shetty, David Spencer, N Nicholas Manolios
BACKGROUND: Literature pertaining to the predictive factors for septic arthritis is limited. AIMS: The primary objective was to investigate the predictive factors for septic arthritis. The secondary objectives were to investigate the predictive factors for crystal arthritis and to explore current practises in the management of acute arthritis. METHODS: A retrospective analysis was undertaken. All patients with an acute arthritis who underwent a joint aspiration for diagnostic and management purposes were considered for inclusion...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29756277/delays-to-diagnosis-and-treatment-of-lung-cancer-in-australia-health-care-professional-perceptions-of-actual-versus-acceptable-timeframes
#6
Ashanya Malalasekera, Haryana M Dhillon, Prunella L Blinman, Steven C Kao, Janette L Vardy
OBJECTIVE: We examined Australian Health Care Professionals' (HCP) perceptions of timeliness of pathways to diagnosis and treatment for people with lung cancer, compared against timeframe guidelines. METHODS: A 21-item survey of HCPs evaluating patient waiting times to diagnosis and treatment of lung cancer was distributed via two Australian conferences, a national Multi-Disciplinary Team directory and email. Main outcome measures were HCP estimates of actual and acceptable waiting times in their practice, and factors contributing to perceived delays...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29741271/new-onset-diabetes-mellitus-among-patients-with-glomerular-diseases
#7
Cynthia C Lim, Maggie Wy Wong, Hui Ling Koh, Yok Mooi Chin, Irene Yj Mok, Jason Cj Choo
BACKGROUND: Glomerulonephritis commonly causes kidney failure. Immunosuppressant treatment may be diabetogenic but data on hyperglycemia in glomerulonephritis treated with usual clinical care is scanty. AIM: We aimed to assess the epidemiology, risk factors and outcomes for New-Onset Diabetes among patients with Glomerular disease (NODAG). METHODS: Single-centre retrospective cohort of non-diabetic adults diagnosed with glomerulonephritis between January 2011 and July 2015...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29740976/high-prevalence-of-diabetes-before-and-after-lung-transplantation-target-for-improving-outcome
#8
Monika Fazekas-Lavu, Michael Reyes, Monique Malouf, Marshall Plit, Adrian Havryk, Lesley V Campbell, Jacqueline R Center, Allan R Glanville, Jerry R Greenfield
BACKGROUND: Diabetes increases morbidity and mortality of lung transplantation. However, the reported prevalence of diabetes varies post-transplantation partly due to lack of detection protocols. AIMS: We determined the prevalence of diabetes in patients (i) waitlisted for lung transplant and (ii) early post-transplantation. METHODS: We analyzed patients on the St Vincent's Heart Lung database from 1/4/14 to 30/9/15 on the waitlist (Study 1) and those transplanted (Study 2)...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29740951/clinical-risk-factors-for-acute-ischemic-and-hemorrhagic-stroke-in-patients-with-infective-endocarditis
#9
Ives Valenzuela, Madeleine D Hunter, Kathryn Sundheim, Bradley Klein, Lauren Dunn, Robert Sorabella, Sang M Han, Joshua Willey, Isaac George, Jose Gutierrez
BACKGROUND: Stroke as a complication of infective endocarditis portends a poor prognosis, yet risk factors for stroke subtype have not been well defined. AIM: To identify risk factors associated with ischemic and hemorrhagic strokes. METHODS: A retrospective patient chart review was performed at a single U.S. academic center to identify risk factors and imaging for patients 18 years or older with infectious endocarditis and stroke diagnoses...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29740934/preventive-effect-of-nicorandil-on-contrast-induced-nephropathy-a-meta-analysis-of-randomized-controlled-trials
#10
Shuang Li, Lin Wang, Yucai Liu, Qiang Hu
BACKGROUNDS: Contrast-induced nephropathy (CIN) is a common and serious side effect in patients undergoing angiocardiography or radiological procedures. We aimed to comprehensively assess the impact of nicorandil on CIN, by gathering currently available data. METHODS AND RESULTS: We searched three main electric databases (Medline/PubMed, EMBASE and Cochrane Central Register of Controlled Trials) from inception through April, 2017. Four randomized controlled trials involving 730 participants were included...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29740931/antimicrobial-prescription-in-patients-dying-from-chronic-obstructive-pulmonary-disease
#11
John Taverner, Lauren Ross, Claire Bartlett, M Luthe, J Ong, Louis Irving, Natasha Smallwood
INTRODUCTION: Despite rising antimicrobial resistance, treatment guidelines for COPD exacerbations are frequently ignored. Patients with terminal conditions are often prescribed antimicrobials despite the goal of care to reduce burdensome treatments. The appropriateness of antimicrobials in patients dying from an exacerbation of COPD is unknown. AIM: To review antimicrobial prescription at the time of death in patients who died from COPD. METHODS: A retrospective medical record audit was performed for 475 patients who died over twelve years (2004-2015)...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29740923/long-term-renal-outcomes-in-multi-ethnic-southeast-asians-with-lupus-nephritis-a-retrospective-cohort-study
#12
Cynthia C Lim, Hui Zhuan Tan, Ying Hao, Yok Mooi Chin, Keng Thye Woo, Choong Meng Chan, Jason Cj Choo
BACKGROUND: Renal involvement is common among Asians with systemic lupus erythematosus and long-term renal outcomes have been described in homogeneous Caucasian and East Asian populations with lupus nephritis but data is scarce for other ethnicities. We aimed to evaluate the incidence and risk factors for progressive chronic kidney disease (CKD) in multi-ethnic South-east Asians with lupus nephritis. METHODS: Single-center retrospective cohort study of adults with biopsy-proven lupus nephritis diagnosed between May 2001 and May 2009...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29740921/hospitalization-and-morbidity-due-to-adverse-drug-reactions-in-elderly-patients-a-single-center-study
#13
Silvia Ognibene, Natale Vazzana, Claudio Giumelli, Luisa Savoldi, Luca Braglia, Giuseppe Chesi
BACKGROUND AND AIMS: Adverse drug reaction (ADRs) is a leading but underrecognized cause of illness particularly in frail subjects with multiple comorbidities. We aimed to investigate the frequency, patterns and outcomes of ADRs as a cause of hospitalization in elderly patients admitted to an internal medicine ward. METHODS: We performed a retrospective observational study including every patient aged over 65 years who was admitted to our Department during a 12-month period...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29717808/how-should-procalcitonin-and-c-reactive-protein-levels-be-interpreted-in-hemodialysis-patients
#14
Nazlim Aktug Demir, Sua Sumer, Gulperi Celik, Rengin Elsurer Afsar, Lutfi Saltuk Demir, Onur Ural
BACKGROUND: Procalcitonin (PCT) and C-reactive protein (CRP) are used most widely in the diagnosis/treatment of bacterial infections. These are not infection-specific and may also show increases in other inflammation-causing cases. AIMS: We aimed to establish a new cut off value for PCT and CRP to eliminate confusion in the diagnosis and treatment of bacterial infections in hemodialysis (HD) patients. METHODS: A total of 1110 patients, 802 with undocumented infection and 308 with documented infection, were included in the study...
May 2, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29717530/the-utility-of-immunohistochemistry-for-mismatch-repair-proteins-on-colorectal-polyps-in-the-familial-cancer-clinic
#15
Eryn Dow, Daniel D Buchanan, Ingrid M Winship
BACKGROUND: Immunohistochemistry for loss of expression of one or more of the mismatch repair proteins is performed on colorectal cancer tissue as a screening test for Lynch syndrome; however, its role in premalignant polyps remains controversial. AIM: To determine the effectiveness of mismatch repair immunohistochemistry performed on premalignant colorectal polyps in identifying Lynch syndrome, focusing on clinical utility and value. METHODS: A retrospective audit was conducted of mismatch repair immunohistochemistry performed on non-malignant polyps in patients who attended the Family Cancer Clinic at the Royal Melbourne Hospital...
May 1, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29665258/health-related-quality-of-life-and-fall-risk-associated-with-age-related-body-composition-changes-sarcopenia-obesity-and-sarcopenic-obesity
#16
Zeynel Abidin Öztürk, İbrahim Halil Türkbeyler, Azer Abiyev, Seval Kul, Bahadır Edizer, Funda Datli Yakaryılmaz, Gülçimen Soylu
BACKGROUND: Sarcopenia, obesity, and sarcopenic obesity are various features of the aging process that can cause important health issues. The present study was undertaken to investigate the interrelationship between those body composition changes including their clinical components and the quality of life variables. METHODS: 423 individuals aged 65 years or more were included in this cross-sectional study. Sarcopenia was diagnosed according to The European Working Group on Sarcopenia in Older People criteria...
April 17, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29663629/examination-of-the-relationship-between-disease-activity-and-patient-reported-outcome-measures-in-an-inflammatory-bowel-disease-cohort
#17
Belinda D Jackson, Danny Con, Alexandra Gorelik, Danny Liew, Simon Knowles, Peter De Cruz
BACKGROUND: The extent to which disease activity impacts on patient reported outcomes (PROs) is unclear. AIMS: The purpose of this study was to examine the relationship between disease activity and PROs. METHODS: Adult IBD patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (SCCAI, HBI), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (HADS), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PROs...
April 16, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29663620/media-reporting-of-health-interventions-in-new-zealand-a-retrospective-analysis
#18
Christian Robinson, Nick Cutfield, John Mottershead, Assoc Prof Katrina Sharples, Rosalina Richards, Jason Kingan, Celina Ledgard, Anuja Liyanage, Jennifer McLean, Fouad Nahab, Fergus Stewart, Samuel Strachan, Kathryn Tucker, Zhiyuan Zhang
AIM: To evaluate New Zealand media articles on their coverage of key issues regarding health interventions and whether it is consistent with available evidence. METHODS: A retrospective analysis was carried out of all articles published in five New Zealand media sources over a six-week period between 15 October and 26 November 2014. Articles were included if their primary focus was on health interventions involving medications, devices or in-hospital procedures...
April 16, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29660234/evaluation-of-chronic-kidney-disease-in-cancer-patients-is-there-a-preferred-estimation-formula
#19
Ghassan Sleilalty, Elie El Rassy, Tarek Assi, Nathalie Al Rassy, Jessica Naseh, Jamale Rizkallah, Serge Finianos, Hiba Azar, Dania Nehme Chelala, Fadi El Karak, Joseph Kattan, Marwan Ghosn
BACKGROUND: The evaluation of chronic kidney disease in cancer patients seems to rely mostly on the Cockcroft-Gault (CG) formula or the creatinine levels to adjust treatment dosages which is a practice refuted by internists. AIMS: We evaluate the overall agreement of the CG, MDRD and CKD-EPI equation with the newly devised Janowitz and Williams' (JW) equation. METHODS: The renal function was estimated in 235 cancer patients according to the CG, MDRD, body surface area (BSA)-adjusted MDRD, CKD-EPI, BSA-adjusted CKD-EPI and JW formulae...
April 16, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29660226/delays-in-lung-cancer-referral-pathways-between-rural-and-urban-patients-in-north-queensland-a-mixed-methods-study
#20
R Verma, S Pathmanathan, Z Otty, J Binder, V Vangaveti, P Buttner, S Sabesan
INTRODUCTION: Aims of this study were to examine time delays in lung cancer referral pathways in North Queensland (NQ), Australia, and explore patients' perspective of factors causing these delays. METHODS: Prospective study of patients attending three cancer centres in Townsville, Cairns and Mackay in NQ from 2009 to 2012. Times along referral pathway were divided as follows: Onset of symptoms to treatment (T1), symptoms to general practitioner(GP) (T2), GP to specialist (T3), and Specialist to treatment (T4)...
April 16, 2018: Internal Medicine Journal
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