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Internal Medicine Journal

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https://www.readbyqxmd.com/read/29345413/hepatitis-b-screening-before-rituximab-therapy-a-multicentre-south-australian-study-of-adherence
#1
Samuel Al Hall, Abdul Shaikh, KailinTeh, Mahsa Tantiongco, Douglas Coghlan, Chris S Karapetis, Mohammad A Chinnaratha, Richard Woodman, Kate R Muller, Alan J Wigg
Background and Aims International guidelines recommend screening for Hepatitis B virus (HBV) infection prior to administration of rituximab, due to high risk of HBV reactivation in at risk patients. The aim of this study was to determine; (1) adherence to the South Australian (SA) protocol for HBV screening, (2) HBV prevalence in patients receiving rituximab, and (3) outcomes of patients at risk of HBV reactivation. METHODS: All patients commenced on rituximab at the 6 major SA public hospitals during a 12-month period were included in the study...
January 18, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29345411/ethnicity-socioeconomic-status-and-the-severity-and-course-of-non-cystic-fibrosis-bronchiectasis
#2
Sally de Boer, Christopher A Lewis, Wendy Fergusson, Kevin Ellyett, Margaret L Wilsher
Background and aims This study evaluated whether there are ethnic factors which affect the severity and progression of bronchiectasis in our adult multi-ethnic population in Auckland, New Zealand. METHODS: Clinical records were reviewed from patients attending the outpatient facilities of our institution between 2007 and 2010. Data collected included demographics, clinical features, smoking status, self-reported ethnicity, socioeconomic status (NZDep), pulmonary function and sputum microbiology...
January 18, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29345405/abdominal-paracentesis-use-of-a-standardised-procedure-checklist-and-equipment-kit-improves-procedural-quality-and-reduces-complications
#3
J Fyson, L Chapman, M Tatton, Z Raos
Goals To evaluate the effect of a Standardised Procedure Checklist (PC) and Equipment Kit (EK) on procedural quality and complication rates for abdominal paracentesis. BACKGROUND: Paracentesis is a common invasive procedure performed by junior doctors. Audit of procedure conduct at two New Zealand hospitals in 2012 revealed poor performance across a range of quality measures including documentation of informed consent, excessive catheter dwell times, and inappropriate albumin prescription...
January 18, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29345403/improving-patient-adherence-to-secondary-prevention-medications-6-months-after-an-acute-coronary-syndrome-observational-cohort-study
#4
D B Brieger, C Chow, J Gullick, K Hyun, M D'Souza, T Briffa
BACKGROUND: Most patients are recommended secondary prevention pharmacotherapies following an acute coronary syndrome (ACS). AIMS: To identify predictors of adherence at 6 months and strategies to improve adherence to these therapies. Design and methods Patients in the CONCORDANCE registry who were discharged on evidence-based medications were stratified into those receiving ā‰„75% ('adherent') or <75% ('non-adherent') of indicated medications at 6 months. Baseline characteristics, hospital and post-discharge care were compared between groups...
January 18, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29345398/music-reduces-state-anxiety-scores-in-patients-undergoing-pleural-procedures-a-randomized-controlled-trial
#5
John Mackintosh, Grace Cone, Kate Harland, Krishna B Sriram
BACKGROUND: Patient anxiety is an often overlooked complication of pleural diagnostic and therapeutic procedures. Listening to music is effective in reducing patient anxiety in some endoscopy procedures but has not yet been evaluated in pleural procedures. METHODS: Consecutive patients undergoing therapeutic pleural procedures were randomised to music and control groups. Participants in the music group listened to self selected music using ear-bud headphones for the duration of the procedure...
January 18, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29345397/characteristics-of-patients-who-progress-from-bridging-to-long-term-oxygen-therapy
#6
Kovi Levin, Brigitte Borg, Belinda Miller, Kirk Kee, Eli Dabscheck
BACKGROUND AND OBJECTIVE: Patients with persistent hypoxia following an acute hospital admission may be discharged with "bridging" domiciliary oxygen as per criteria defined by the Thoracic Society of Australia and New Zealand. The need for continuous Long-Term Oxygen Therapy (LTOT) is then reassessed at a clinic review 1-2 months later. The aim of this study is to describe the characteristics of patients discharged from an acute hospital admission with continuous Short Term Oxygen Therapy (STOT), and subsequently to investigate for differences between subjects who proceeded to qualify for continuous LTOT versus those who were able to cease STOT at review...
January 18, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29316133/diabetic-ketoacidosis-in-adult-patients-an-audit-of-factors-influencing-time-to-normalisation-of-metabolic-parameters
#7
Melissa H Lee, Genevieve L Calder, John D Santamaria, Richard J MacIsaac
BACKGROUND: Diabetic ketoacidosis (DKA) is an acute life-threatening metabolic complication of diabetes that imposes substantial burden on our healthcare system. There is a paucity of published data in Australia assessing factors influencing time to resolution of DKA and length of stay (LOS). AIMS: To identify factors that predict a slower time to resolution of DKA in adults with diabetes. METHODS: Retrospective audit of patients admitted to St Vincent's Hospital Melbourne between 2010 to 2014 coded with a diagnosis of 'Diabetic Ketoacidosis'...
January 8, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29316115/multimorbidity-not-hiv-markers-predicts-unplanned-admission-among-people-with-hiv-in-regional-nsw
#8
Natalie Edmiston, Kathy Petoumenos, David J Smith
BACKGROUND: Multimorbidity and unplanned admissions are common among people with HIV (PWH). AIMS: The aim was to determine factors predictive of unplanned admission among PWH in regional NSW and compare care coordination between people with and without unplanned admissions. METHOD: A prospective cohort study of PWH attending a regional HIV service was conducted. Baseline HIV specific results and multimorbidity markers including Cumulative Illness Rating Scale (CIRS) were assessed as predictors of time to first unplanned admission using cox regression analysis...
January 8, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29316113/drug-induced-liver-injury-is-frequently-associated-with-severe-cutaneous-adverse-drug-reactions-experience-from-two-australian-tertiary-hospitals
#9
Wendy C Fang, Nikki R Adler, Linda V Graudins, Caitlin Goldblatt, Michelle Sy Goh, Stuart K Roberts, Jason A Trubiano, Ar Kar Aung
BACKGROUND: Drug-induced liver injury can be associated with certain cutaneous adverse drug reactions. AIMS: We aim to demonstrate the prevalence of drug-induced liver injury in patients with cutaneous adverse drug reactions. Severity and patterns of liver injury, risk factors, causal medications and outcomes are also examined. METHODS: A retrospective cohort study of patients with cutaneous adverse drug reactions was conducted across two hospitals in Australia...
January 8, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29283473/international-statistical-classification-of-diseases-and-related-health-problems-coding-underestimates-the-incidence-and-prevalence-of-acute-kidney-injury-and-chronic-kidney-disease-in-general-medical-patients
#10
Soe Ko, Sudharsan Venkatesan, Kushma Nand, Vicki Levidiotis, Craig Nelson, Edward Janus
BACKGROUND: The International classification of diseases (ICD) code is frequently used to identify renal impairment in epidemiologic research. However, Australian studies examining accuracy of this administrative data in coding kidney injury are lacking. AIMS: To compare the ICD 10 coding with the Kidney Disease: Improving Global Outcomes (KDIGO) criteria in diagnosing Acute Kidney Injury (AKI) and/or Chronic Kidney Disease (CKD). METHODS: A retrospective study of 325 patients admitted to General Medicine during January 2012 was performed...
December 28, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29236347/the-full-blood-count-as-an-ancillary-test-to-support-the-diagnosis-of-giant-cell-arteritis
#11
Lawrence J Oh, Eugene Wong, Juliana Andrici, Peter McCluskey, James E H Smith, Anthony J Gill
BACKGROUND: Temporal artery biopsy is considered the investigation of choice to definitively diagnose giant cell arteritis in patients with compatible symptoms. However it is invasive and not completely sensitive. Serum markers, particularly ESR, can be supportive but are not definitive in individual cases. AIMS: We sought to investigate whether indices derived from the full blood count including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), were associated with a positive biopsy in patients with suspected giant cell arteritis...
December 13, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29236346/therapy-related-acute-myeloid-leukaemia-and-myelodysplastic-syndrome-in-victoria-australia-2003-2014
#12
Doen Ming Ong, Helen Farrugia, Andrew Wei
BACKGROUND: The burden of therapy-related acute myeloid leukaemia (tAML) / therapy-related myelodysplastic syndrome (tMDS) in Australia has not been characterized. METHODS: We analysed adults aged ā‰„20 years at diagnosis of acute myeloid leukaemia (AML) / myelodysplastic syndrome (MDS) reported to the Victorian Cancer Registry (VCR) between 2003-2014. RESULTS: 73/3,120 (2.3%) AML cases were classified tAML. tAML patients were younger than non-tAML patients at diagnosis (median age 66 vs...
December 13, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29230931/temporal-changes-in-glycaemic-thresholds-for-treatment-intensification-in-type-2-diabetes-in-an-urban-australian-setting-the-fremantle-diabetes-study
#13
Timothy M E Davis, Stephen A P Chubb, Bradley H Curtis, Helen Barraclough, Wendy A Davis
BACKGROUND: Pharmacotherapy and supportive care for diabetes in Australia are improving, with potential beneficial effects on therapeutic procrastination. AIMS: To determine whether glycaemic thresholds for therapeutic intensification in type 2 diabetes changed over the 15 years between Phases of the community-based Fremantle Diabetes Study (FDS). METHODS: We studied 531 Phase 1 participants (mean age 62.4 years, 54.2% males, median diabetes duration 3...
December 12, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29230923/primary-antifungal-prophylaxis-decrease-of-invasive-fungal-disease-incidence-and-reduction-of-risk-factors-in-hematological-patients-in-a-5-year-retrospective-study
#14
Yan Li, Mingjuan Liu, Bing Zhai, Xiaoli Zhao, Lijun Wang, Honghua Li, Shuhong Wang, Haiyan Zhu, Quanshun Wang, Chunji Gao, Wenrong Huang, Li Yu
BACKGROUND: Invasive fungal disease (IFD) is a major cause of morbidity and mortality in patients with hematological malignancies. AIM: To evaluate the efficacy and rationality of primary antifungal prophylaxis (PAP) in a 5-year real life setting and choose an appropriate PAP strategy. METHODS: Clinical data of patients were retrospectively reviewed and IFD was diagnosed using the revised diagnostic criteria. The efficacy of PAP and the risk factors for IFD, especially the rationality of PAP, were evaluated...
December 12, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29227565/limited-utility-of-routine-chest-x-ray-in-initial-evaluation-of-neutropenic-fever-in-patients-with-haematological-diseases-undergoing-chemotherapy
#15
Ortis Estacio, Zoe Loh, Amy Baker, Geoff Chong, Andrew Grigg, Leonid Churilov, Eliza A Hawkes
BACKGROUND: Routine chest X-Ray (CXR) is recommended for neutropenic fever(NF) management however its role is relatively understudied in haematology patients. METHODS: Retrospective, single-centre analysis of haematology patients admitted with NF between January 2011-December 2015. Baseline demographics, treatment details and outcomes were collected from electronic patient records. CXRs underwent independent radiology review. Primary endpoints were proportion of NF episodes in which CXR detected a probable chest infection in the absence of respiratory symptoms/signs, and/or resulted in a change in antibiotic management...
December 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29206334/non-diabetic-renal-diseases-in-patients-with-type-2-diabetes-a-single-center-study
#16
Jian-Zhen Fan, Rong Wang
OBJECTIVE: To analyse the pathological characteristics and distribution of renal injury in selected type 2 diabetic patients. Comparison between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) in clinical characteristics, to find important predictors for NDRD. METHODS: To conduct retrospective analysis of clinical, laboratory and pathohistological data of type 2 diabetic patients in whom renal biopsies were performed from March 2010 to September 2014 in Shandong Provincial Hospital affiliated to Shandong University (nā€‰=ā€‰88)...
December 5, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29205742/trends-in-outpatient-anti-arrhythmic-prescriptions-for-atrial-fibrillation-and-left-atrial-ablation-in-australia-1997-2016
#17
Ifrah Khan, Hitesh C Patel, Shane Nanayakkara, Hariharan Raju, Aleksandr Voskoboinik, Justin A Mariani
BACKGROUND: An important aspect of atrial fibrillation (AF) management is the decision whether to adopt a rate or rhythm control strategy. Options for the latter include oral anti-arrhythmic drugs (AADs) or catheter ablation. AIM: We sought to describe the trends in rhythm control for AF in Australia between 1997 and 2016. METHODS: We conducted a retrospective study using prospectively collected data between 1997 - 2016 from the Pharmaceutical Benefit Scheme and Medicare Benefit Schedule websites, which respectively contain information pertaining to public AAD prescriptions and rebatable AF ablation procedures performed in the Australia...
December 5, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29193523/barriers-to-medication-adherence-and-links-to-cardiovascular-disease-risk-factor-control-the-framingham-heart-study
#18
Rachel Hennein, Shih-Jen Hwang, Rhoda Au, Daniel Levy, Paul Muntner, Caroline S Fox, Jiantao Ma
BACKGROUND: In the elderly, impaired cognition may weaken medication adherence and compromise treatment for cardiovascular disease (CVD). AIMS: We examined risk factors for medication adherence and the relationship between adherence and levels of CVD risk factors among older participants with hypertension, dyslipidemia, and diabetes in the Framingham Heart Study. METHODS: The four-item Morisky Medication Adherence Scale was administered to 1,559 participants, median age 70 years, 53% women...
November 30, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29193646/quantifying-the-hidden-healthcare-cost-of-diabetes-mellitus-in-australian-hospital-patients
#19
Amalia Karahalios, Gowri Somarajah, Peter S Hamblin, Harin Karunajeewa, Edward D Janus
BACKGROUND: Diabetes mellitus in hospital inpatients is most commonly present as a co-morbidity rather than as the primary diagnosis. In some hospitals, the prevalence of co-morbid diabetes mellitus across all inpatients exceeds 30%, which could add to complexity of care and resource utilization. However, whether and to what extent co-morbid diabetes mellitus contributes indirectly to greater hospitalization costs is ill-defined. AIM: This study determined the attributable effect of co-morbid diabetes mellitus on hospital resource utilisation in a General Internal Medical service in Melbourne, Australia...
November 29, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29193638/delayed-diagnosis-of-atrial-fibrillation-after-first-ever-stroke-increases-recurrent-stroke-risk-a-5-year-nationwide-follow-up-study
#20
Ping-Song Chou, Bo-Lin Ho, Yi-Hsin Chan, Min-Hsien Wu, Han-Hwa Hu, A-Ching Chao
BACKGROUND: Delayed detection of atrial fibrillation (AF) is common in patients with stroke. However, it is not well known whether delayed identification of AF in patients with stroke affects the prognosis of patients. AIMS: The aim of this study was to evaluate the association between the timing of AF diagnosis after stroke and clinical outcomes. METHODS: We identified a cohort of all patients admitted with a primary diagnosis of first-ever ischemic stroke, which was categorized into three groups, namely non-AF, AF presenting with stroke, and delayed AF diagnosis groups...
November 29, 2017: Internal Medicine Journal
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