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Internal Medicine Journal

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https://www.readbyqxmd.com/read/28782248/risk-stratification-in-the-investigation-of-pulmonary-nodules-in-a-high-risk-cohort-pet-ct-outperforms-clinical-risk-prediction-algorithms
#1
Glenna Gibson, Aravind Ravi Kumar, Karin Steinke, Farzad Bashirzadeh, Rebecca Roach, Morgan Windsor, Robert Ware, David Fielding
BACKGROUND: Clinical prediction models and 18F-FDG-PET/CT are used for assessment of solitary pulmonary nodules (SPNs) however biopsy is still required before treatment which carries risk. AIM: To determine combined predictive benefit of one such model combined with modern PET/CT data to improve decision making about biopsy prior to treatment and possibly reduce costs. METHOD: Patients with a SPN undergoing 18F-FDG-PET/CT from January 2011-December 2012 were retrospectively identified...
August 7, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28782163/statin-associated-immune-mediated-necrotising-myopathy-a-new-zealand-case-series-showing-possible-over-representation-in-pacific-islanders
#2
Michelle Claudine Woolley, Simon Stebbings, John Highton
AIMS: To review incident cases of statin-associated immune mediated necrotising myopathy (IMNM) associated with anti-HMGCR antibodies in a single New Zealand centre, over a two year period. METHODS: Four incident cases of statin-associated IMNM were seen between 2014 and 2016. Their presentation, investigation, treatment and current response to treatment are summarised. Two of the four patients were Pacific Islanders despite a small pacific island population in the southern district health board (SDHB)...
August 7, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28762618/exploring-disparities-in-receipt-of-adjuvant-chemotherapy-in-culturally-and-linguistically-diverse-cald-groups-an-australian-centre-s-experience
#3
Alesha A Thai, Mark Tacey, Amanda Byrne, Shane White, Jaclyn Yoong
BACKGROUND: Globally, racial and ethnic disparities exist in treatments and outcomes for cancer patients. In Australia, there is little published data relating to cancer patients from culturally and linguistically diverse (CALD) backgrounds. AIM: To explore disparities in adjuvant chemotherapy utilisation in cancer patients from CALD groups. METHODS: Retrospective analysis of patients who were recommended adjuvant chemotherapy for early-stage breast cancer (eBC) or early-stage colorectal cancer (eCRC) between July 2011 and October 2014...
August 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28762609/postural-change-in-convulsive-seizures-a-retrospective-review-of-video-eeg-recordings
#4
Jane Rigg, Kimberley Irwin, Fred Tremayne, David Reutens
OBJECTIVES: Prone position has been identified as an important risk factor for Sudden Unexpected Death in Epilepsy (SUDEP) raising the possibility of avoidance of this posture in sleep as a preventative measure. To evaluate the potential utility of such postural measures, we studied patterns of postural change during generalised tonic clonic seizures (GTCSs). METHODS: Video electroencephalographic (video-EEG) recordings for patients undergoing investigations at the Royal Brisbane and Women's Hospital between 2005 and 2013 were reviewed independently by two raters...
August 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28762600/assessing-the-practice-of-palliative-care-doctors-what-driving-advice-do-they-give-patients-with-advanced-disease
#5
Nashringi Weir, Amanda Fischer, Phillip Good
BACKGROUND: There is little research and no clear guidelines for clinicians to follow when instructing patients with advanced disease about driving. AIMS: To investigate current practice in providing advice to patients with advanced disease and identify areas of consensus or variation with the Australian driving guidelines. METHODS: An online survey was distributed to Australian members of the Australian and New Zealand Society of Palliative Medicine (ANZSPM)...
August 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742280/clinical-outcomes-in-patients-with-advanced-egfr-mutated-non-small-cell-lung-cancer-in-south-western-sydney-local-health-district
#6
P N Ding, T L Roberts, W Chua, T M Becker, J Descallar, P Y Yip, V J Bray
AIMS: We aim to describe clinical characteristics, treatment patterns and factors influencing outcomes in patients with EGFR-mutated non-small cell lung cancer (NSCLC) in SWSLHD. METHODS: Retrospective review of patients with EGFR-mutated NSCLC diagnosed between January 2010 and June 2016. RESULTS: A total of 85 EGFR-mutated NSCLC patients were identified; 80 (94%) received first line treatment with EGFR-TKI. The median follow-up was 10.7 months with a median duration of treatment of 9 months...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742270/malignancy-screening-in-autoimmune-myositis-amongst-australian-rheumatologists
#7
Katherine Dutton, Muriel Soden
BACKGROUND: The international literature advocates for cancer screening in newly diagnosed patients with autoimmune myositis; however there is no widely-accepted consensus or guideline to outline the optimal cancer screening strategy and the evidence is currently insufficient to support any recommendation. AIMS: Our study aimed to establish the current trends in practice in malignancy screening in autoimmune myositis amongst Australian Rheumatologists. METHODS: All Rheumatologists who were full members of the Australian Rheumatology Association in 2016 (386) were invited to complete an online questionnaire...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742259/off-label-use-of-rituximab-in-autoimmune-disease-in-the-top-end-of-the-northern-territory-2008-2016
#8
Sarah Wongseelashote, Vipin Tayal, Peter Francis Bourke
BACKGROUND: Rituximab, an anti-CD20 B cell depleting monoclonal antibody, is increasingly prescribed off-label for a range of autoimmune diseases. There has not previously been an audit of off-label rituximab use in the Northern Territory, where the majority of patients are Aboriginal. AIMS: To retrospectively evaluate off-label rituximab use in autoimmune diseases in the Top End of the Northern Territory. METHOD: We performed a retrospective audit of eight years of off-label rituximab use at the Royal Darwin Hospital, the sole tertiary referral centre for the Darwin, Katherine and East Arnhem regions...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742229/association-between-obesity-with-low-muscle-mass-and-dialysis-mortality
#9
Hung-Chieh Wu, Shih-Fen Tseng, Wei-Jie Wang, Hsin-Jen Chen, Lin-Chien Lee
AIMS: This study examines the association between body composition and dialysis mortality. METHODS: Adult patients who initiated hemodialysis in Taoyuan General Hospital from 2012 to 2016 were enrolled. We reviewed baseline characteristics and followed over 5 years after dialysis. Patients with body mass index > 25 Kg/m(2) were defined as obesity. High or low muscle mass were classified by skeletal muscle mass index (SMMI) based on consensus from Chinese population...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742226/documentation-of-penicillin-adverse-drug-reactions-in-electronic-health-records-inconsistent-use-of-allergy-and-intolerance-labels
#10
Joshua M Inglis, Gillian E Caughey, William Smith, Sepehr Shakib
BACKGROUND: The majority of patients with penicillin allergy labels tolerate penicillins. Inappropriate avoidance of penicillin is associated with increased hospitalisation, infections and healthcare costs. AIMS: To examine the documentation of penicillin adverse drug reactions (ADR) in a large-scale hospital-based electronic health record. METHODS: Penicillin ADRs were extracted from 96,708 patient records in the Enterprise Patient Administration System in South Australia...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742223/impact-and-implementation-of-a-sustainable-regional-telestroke-network
#11
Annemarei Ranta, Jeremy Lanford, Suzanne Busch, Carolyn Providence, Ivan Iniesta, Ian Rosemergy, Andrew Wilson, Pietro Cariga, Victoria Richmond, John Gommans
INTRODUCTION: Telestroke uses videoconferencing (VC) technology to allow off-site experts to provide stroke thrombolysis decision support to less experienced front line clinicians. This project aimed to assess the impact of a new telestroke service on thrombolysis rates and door-to-needle times in participating provincial hospitals and service resources to aid transition to a sustainably telestroke service. METHODS: This is a sequential comparison of 'pre' (December 2015 to May 2016) and 'postr' (June 2016 to December 2016) implementation outcomes...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28707749/new-insights-into-sinusoidal-obstruction-syndrome
#12
Andrea Piccin, Maria Teresa Sartori, Gianni Bisogno, Muriel Van Schilfgaarde, Graziella Saggiorato, Angela Maria Di Pierro, Daisy Corvetta, Luigi Marcheselli, Mega Andrea, Günther Gastl, Simone Cesaro
We studied the relationships between endothelial extracellular vesicles (EV) and plasminogen-activator inhibitor type 1(PAI-1), to assess their modification in the early phase of sinusoidal obstruction syndrome (SOS). ENTRY CRITERIA: patients who developed SOS at single center from January 2000 to December 2011. SELECTION: patients who underwent hematopoietic stem cell transplantation (HSCT) or actinomicyn-based chemotherapy for nephroblastoma. PARTICIPANTS: the study group comprised 5 patients with SOS who were compared with a control group of 7 patients without SOS...
July 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28696571/acute-evaluation-of-the-acute-vestibular-syndrome-differentiating-posterior-circulation-stroke-from-acute-peripheral-vestibulopathies
#13
REVIEW
Benjamin Kwok-Tung Tsang, Alex Siew-Kar Chen, Mark Paine
This review article aims to provide an evidence-based approach to evaluating the patient who presents with acute prolonged, spontaneous vertigo in the context of the acute vestibular syndrome (AVS). Differentiation of posterior circulation stroke presenting as an acute vestibular syndrome has been regarded as an important diagnostic challenge for physicians involved in acute care. Current evidence suggests that a targeted approach to history taking and physical examination with emphasis on the oculomotor examination, more specifically the HINTS (Head Impulse/ Nystagmus/Test-of-skew) examination battery, yields a higher sensitivity for diagnosis of posterior circulation stroke than even standard magnetic resonance imaging with diffusion weighted imaging...
July 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28696562/association-between-nonalcoholic-fatty-liver-disease-and-peripheral-artery-disease-in-patients-with-type-2-diabetes
#14
Yaowu Zou, Xinde Li, Can Wang, Jing Wang, Fei Wang, Lidan Ma, Wenjun You, Changgui Li
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with risk of coronary heart diseases; however, the relationship between NAFLD and peripheral artery disease (PAD) in patients with type 2 diabetes has not been investigated. AIMS: To investigate the association between NAFLD and PAD in patients with type 2 diabetes patients. METHODS: We carried out a cross-sectional study in 2646 type 2 diabetes patients ≥ 40 years...
July 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28696520/delays-in-presentation-and-diagnosis-of-pulmonary-tuberculosis-a-retrospective-study-of-a-tertiary-health-service-in-western-melbourne-2011-2014
#15
Eloise Williams, Allen Cheng, Garry P Lane, Stephen David Guy
BACKGROUND: Effective tuberculosis (TB) control relies on early diagnosis and prompt treatment commencement. AIM: To investigate delays in presentation and diagnosis of pulmonary TB (PTB) in a low incidence setting in western Melbourne. METHODS: A single-centered retrospective observational cohort study of symptomatic patients ≥ 18 years newly diagnosed with PTB that were commenced on treatment between 1(st) December 2011 and 1(st) December 2014 at a tertiary teaching hospital in western Melbourne...
July 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28675669/a-two-year-audit-of-outcomes-of-pituitary-surgery-at-an-australian-teaching-hospital
#16
Timothy M E Davis, Imran Badshah, Jocelyn Drinkwater, Emily Kusich, Erin Latkovic, Neville Knuckey
BACKGROUND: There is evidence that cure rates and complications are influenced by the case load in neurosurgical centres performing transsphenoidal pituitary surgery. Although Australian centres may perform relatively small numbers of these procedures, there have been few published audits of their performance. AIMS: To conduct an audit of surgery for pituitary tumours between 2012 and 2014 in the only public hospital neurosurgical unit in the state of Western Australia...
July 4, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28675639/prevalence-and-associations-of-psychological-distress-in-australian-junior-medical-officers
#17
Michelle W Lau, Wenlong Eric Li, Anthony Llewellyn, Allan M Cyna
AIMS: To determine the prevalence of psychological distress in Australian Junior Medical Officers (JMOs) and investigate the determinants associated with psychological distress over a three year (2014-2016) period. METHODS: JMOs were surveyed using the 2014-2016 JMO Census (n = 220, 399, and 466 each year, response rate approximately 15%). Levels of psychological distress were assessed using the Kessler Psychological Distress Scale (K10). A K10≥ 25 was chosen to indicate high psychological distress and this determinant was compared to various demographic and work-related factors...
July 4, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28675622/early-radiological-intervention-and-haematology-screening-is-associated-with-excellent-outcomes-in-budd-chiari-syndrome
#18
Allison Mo, Adam Testro, Janine French, Marcus Robertson, Peter Angus, Andrew Grigg
BACKGROUND: Budd Chiari Syndrome (BCS) is a rare and life-threatening disorder, resulting from thrombosis of the hepatic veins. Various treatments including pharmacological, radiological and surgical interventions have been used. AIM: We aimed to retrospectively describe our institution's experience with management of patients with BCS. RESULTS: Between 2000 and 2012, 27 patients with primary BCS presented with a median Rotterdam score of 1...
July 4, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28675538/the-frequency-and-risk-factors-of-colorectal-adenoma-in-patients-with-early-gastric-cancer
#19
Hyun Hee Chung, Kyeong Ok Kim, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
BACKGROUND/AIMS: The authors aimed to determine the clinical value of colonoscopy by evaluating the frequency of colorectal neoplasm detection in patients with early gastric cancer (EGC) as compared with healthy controls and analyzed the risk factors of advanced colorectal neoplasm in patients with EGC. METHODS: The medical records of 201 patients diagnosed as EGC and age and gender matched healthycontrols were retrospectively reviewed. Frequencies and clinical features of colorectal polyps of patients and controls were compared...
July 4, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28636094/characterization-of-clonal-philadelphia-negative-cytogenetic-abnormalities-in-a-large-cohort-of-chronic-myeloid-leukemia
#20
Xiangjun Chen, Jine Zheng, Kaiwei Liang, Yanli He, Wen Du, Juan Li, Wei Liu, Yanjie Hu, Junxia Yao
OBJECTIVES: Clonal Philadelphia-negative Cytogenetic Abnormalities (CPCA) have been reported in chronic myeloid leukaemia (CML) patients treated with either interferon or tyrosine kinase inhibitor (TKI). However, the incidences and types of these cytogenetic abnormalities after treatment vary due to the limited populations enrolled. METHODS: We analysed the frequency and types of CPCA in a cohort of 607 CML patients in the chronic phase after TKI treatment. We also followed up these CPCA with a median of 31...
June 21, 2017: Internal Medicine Journal
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