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Internal Medicine Journal

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https://www.readbyqxmd.com/read/28328109/a-cohort-study-of-gorlin-syndrome-with-emphasis-on-standardised-phenotyping-and-quality-of-life-assessment
#1
Aamira J Huq, Michael Bogwitz, Alexandra Gorelik, Ingrid M Winship, Susan M White, Alison H Trainer
BACKGROUND: Gorlin syndrome (Nevoid Basal Cell Carcinoma Syndrome) is a rare genetic predisposition to basal cell carcinomas (BCCs), keratocysts of the jaw and calcification of the falx cerebri amongst other clinical features. With the advent of sonic hedgehog inhibitors for the treatment of BCCs, it is timely to establish a cohort of individuals with Gorlin syndrome and collect standardised phenotypic information on these individuals. Moreover, the health-related quality of life (QoL) in individuals with Gorlin syndrome is not well studied...
March 22, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28321977/the-relationship-between-hp-infection-and-vomiting-induced-by-gastrointestinal-cancer-chemotherapy
#2
Yiwei Yao, Chushu Ji, Yifu He, Yueyin Pan
BACKGROUND: Nausea and vomiting are the most common adverse reactions to chemotherapy. AIM: To discuss the relationship between Helicobacter pylori (HP) and chemotherapy-induced nausea and vomiting (CINV). METHODS: One hundred twelve patients with malignant tumours of the gastrointestinal tract were selected. Based on the 14C-urea breath test results, the patients were divided into HP-positive (n = 59) and HP-negative (n = 53) groups...
March 21, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28321964/combination-therapy-of-leflunomide-and-glucocorticoids-for-the-maintenance-of-remission-in-patients-with-igg4-related-disease-a-retrospective-study-and-literature-review
#3
Yiwen Wang, Kunpeng Li, Dai Gao, Gui Luo, Yurong Zhao, Xiuru Wang, Jie Zhang, Jingyu Jin, Zheng Zhao, Chunhua Yang, Jian Zhu, Jianglin Zhang, Feng Huang
BACKGROUND: Although glucocorticoids are effective in IgG4-related disease (IgG4-RD), patients may relapse during or after glucocorticoid tapering. Immunosuppressive agents including leflunomide (LEF) are regarded as steroid-sparing agents in other autoimmune disorders and need to be discussed in the management of IgG4-RD. AIM: To identify the efficacy and safety of combination therapy of LEF and glucocorticoids in IgG4-RD. METHODS: We retrospectively summarized data of patients diagnosed with IgG4-RD between November 2012 and November 2015...
March 21, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28321963/outcomes-and-predictors-of-harmful-relapse-following-liver-transplantation-for-alcoholic-liver-disease-in-an-australian-population
#4
Alan J Wigg, Dileep Mangira, John W Chen, Richard W Woodman
AIMS: Limited studies of patient survival and alcoholic relapse following transplantation for alcoholic liver disease have been described in Australian populations. The aim of this study was therefore to describe these outcomes in an Australian population, to determine the association between harmful alcoholic relapse and patient survival, and to examine pre transplant variables associated with harmful relapse. METHODS: Single center, retrospective review of consecutive patients transplanted at the South Australian Liver Transplant Unit...
March 21, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28276136/initial-diagnosis-and-management-of-chronic-obstructive-pulmonary-disease-in-australia-views-from-the-coal-face
#5
Bonnie Bereznicki, Haydn Walters, Julia Walters, Gregory Peterson, Luke Bereznicki
BACKGROUND: Early diagnosis and management can mitigate the long-term morbidity and mortality of chronic obstructive pulmonary disease (COPD). AIM: To gain insights into the initial diagnostic process and early management of COPD by Australian general practitioners (GPs). METHODS: A random sample of Australian GPs was invited to complete a postal survey, which assessed familiarity with and use of contemporary practice guidelines, diagnostic criteria, and management preferences for COPD...
March 9, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28276127/heyde-s-syndrome-revisited-anaemia-and-aortic-stenosis
#6
Catherina Tjahjadi, Yong Wee, Karen Hay, Peter Tesar, Andrew Clarke, Darren L Walters, Nicholas Bett
BACKGROUND: The association of anaemia with aortic stenosis (AS) has been recognised for over 50 years but although there have been a number of sporadic reports there are little data on the prevalence of this syndrome. AIMS: We sought to compare the prevalence of anaemia in adults with AS with that of controls who had undergone coronary artery bypass grafting (CABG). METHODS: We conducted a retrospective cohort study comparing pre-procedural levels of haemoglobin in 1537 adults who underwent aortic valve replacement (AVR) for AS with 8025 contemporaneous patients who had CABG...
March 9, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28266121/reigniting-compassion-into-healthcare-manaakitia-reflective-rounds
#7
S Shah, I Lambrecht, A O'Callaghan
AIMS: To evaluate the efficacy of monthly case-based, staff-support reflective rounds to discuss complex emotional and psychosocial issues that arise in caring for patients and families. METHODS: At Auckland City Hospital, a pilot programme called Manaakitia Reflective Rounds was delivered between April 2014 and September 2015. These were facilitated one-hour monthly case-based staff support groups to discuss complex emotional and psychosocial issues in caring for patients...
March 7, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28247950/use-of-brentuximab-vedotin-as-salvage-therapy-pre-allogeneic-stem-cell-transplantation-in-relapsed-refractory-cd30-positive-lympho-proliferative-disorders-a-single-centre-experience
#8
Heshani Mediwake, Kirk Morris, Cameron Curley, Jason Butler, Glen Kennedy
AIM: To assess the outcome of use of brentuximab as a bridge to allogeneic stem cell transplant (SCT) in patient with relapsed / refractory CD30+ classic Hodgkin Lymphoma c(HL) and Anaplastic Large Cell Lymphoma (ALCL). METHODS: Outcomes of consecutive patients with relapsed / refractory cHL / ALCL treated with brentuximab as a bridge to SCT were determined by retrospective review of individual medical records. Survival analysis was measured from start of brentuximab treatment...
March 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28229530/an-audit-of-anticholinergic-medication-changes-in-older-hospitalised-patients-using-the-anticholinergic-drug-scale
#9
Michele Lee, Hugh Carl Hanger
OBJECTIVE: In patients discharged from an Older Person's Health hospital, we assessed 1) the prevalence of anticholinergic medications in this study population and 2) changes in anticholinergic drug burden during admission using the Anticholinergic Drug Scale (ADS). METHODS: Cases were identified between September 2010 and January 2011 using discharge coding data. Clinical notes were reviewed to determine which regular oral medications were commenced, altered or ceased during admission with their respective ADS level...
February 23, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28224729/management-of-hypoxaemic-respiratory-failure-in-a-respiratory-high-dependency-unit
#10
Craig Hukins, Mimi Wong, Michelle Murphy, John Upham
BACKGROUND: There are limited data on outcomes of hypoxaemic respiratory failure (HRF), especially in non-ICU settings. AIM: To assess outcomes in HRF (without multi-system disease and not requiring early intubation) directly admitted to a Respiratory High Dependency Unit (R-HDU). METHODS: Retrospective, cohort study of HRF compared to Hypercapnic Respiratory Failure (HCRF) in a R-HDU (2007-2011). Patient characteristics (age, gender, pre-morbid status, diagnoses) and outcomes (non-invasive ventilation (NIV) use, survival, ICU admission) were assessed...
February 22, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28195682/access-to-palliative-care-services-during-the-terminal-hospital-episode-reduces-intervention-rates-and-hospital-costs-a-database-study-of-19707-elderly-patients-dying-in-hospital-2011-2015
#11
Anthony W Ireland
BACKGROUND: The burden of healthcare costs for persons approaching death is of increasing concern. This study examines cost savings associated with access to palliative care (PC) during the hospital episode ending in death for a large sample of elderly patients. METHODS: A retrospective cohort study of administrative data for Department of Veterans' Affairs clients identified patient demographics, hospital characteristics, utilisation data and component costs for the hospital terminal episode for patients aged ≥ 70 years who died in hospital between July 2011 and June 2015...
February 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28195680/disparities-in-the-incidence-of-acute-myocardial-infarction-long-term-trends-from-the-hunter-region
#12
Allan J Davies, Crystal Naudin, Mohammed Al Omari, Arshad Khan, Chris Oldmeadow, Mark Jones, Bruce Bastian, Rohan Bhagwandeen, Peter Fletcher, James Leitch, Andrew Boyle
BACKGROUND: Trends in the incidence of Acute Myocardial Infarction (AMI) provide important information for health care providers and can allow for accurate planning of future health needs and targeted interventions in areas with an excess burden of cardiovascular disease AIMS: To investigate the regional variations in AMI incidence in the Hunter region METHODS: Incident cases of AMI identified between 1996 and 2013 from the Hunter New England Health Cardiac and Stroke Outcomes Unit were prospectively collected for this study...
February 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28195385/practical-approaches-to-commencing-device-assisted-therapies-for-parkinson-s-disease-in-australia
#13
REVIEW
D R Williams, A H Evans, V S C Fung, M Hayes, R Iansek, T Kimber, J D O'Sullivan, C M Sue
BACKGROUND: In Australia 1% of individuals aged over 50 years have Parkinson's disease (PD). AIMS: Guidance for commencing device-assisted therapies (DATs) for PD in Australia was developed based on a review of European recommendations and their relevance to the local clinical setting. METHODS: An online survey and teleconference discussions were held by a group of eight local movement disorder experts to develop consensus. RESULTS: Referral to a movement disorder specialist and consideration of DAT is appropriate when motor fluctuations cause disability or reduced quality of life, response to treatment is inconsistent or motor fluctuations and dyskinesias require frequent treatment adjustment without apparent benefit and levodopa is required four or more times daily...
February 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28150371/venous-thromboembolism-management-practices-and-knowledge-of-guidelines-a-survey-of-australian-haematologists-and-respiratory-physicians
#14
Rory Wallace, Mary-Ann Anderson, Katharine See, Ms Alexandra Gorelik, A/Prof Louis Irving, Renee Manser
BACKGROUND: Current international clinical practice guidelines do not adequately address all clinical scenarios in the management of venous thromboembolism (VTE) and no comprehensive Australian guidelines exist. We aimed to identify areas of uncertainty in VTE management and whether self-reported practice is consistent with guidelines. METHODS: We conducted an Australian cross-sectional online survey consisting of 53 questions to investigate doctors' VTE management practices...
February 2, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28145084/an-exploratory-study-into-the-unmet-supportive-needs-of-people-diagnosed-with-cirrhosis-in-queensland-australia
#15
Patricia C Valery, Paul J Clark, Steven M McPhail, Tony Rahman, Kelly Hayward, Jennifer Martin, Leigh Horsfall, Michael L Volk, Richard Skoien, E Powell
BACKGROUND: Many patients with cirrhosis follow complex medication and dietary regimens and those with decompensated cirrhosis suffer debilitating complications. These factors impact on activities of daily living and quality of life. OBJECTIVE: To explore the concerns and challenges of people with cirrhosis and their use of support services. Also, to describe health professionals' (HP) perspectives of patients' concerns. METHODS: Cross-sectional study at a tertiary liver clinic involving 50 patients and 54 HPs...
February 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28145054/longterm-adherence-to-apomorphine-infusion-in-patients-with-parkinson-s-disease-a-10-year-observational-study
#16
Thomas Edmund Kimber, Jing Fang, Lynda Jane Huddy, Philip Douglas Thompson
BACKGROUND: Patients with Parkinson's disease (PD) commonly experience motor fluctuations and dyskinesias in response to oral dopaminergic medications. Affected patients may benefit from a device-assisted therapy, such as medication infusion or deep brain stimulation surgery. This is the first Australian study of the long term adherence to apomorphine infusion (AI) in patients with PD. AIM: to assess the adherence to AI in patients with PD in a single centre over a 10 year period and, in patients who discontinued AI, the reasons for discontinuation...
February 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28145049/heart-disease-in-east-timor-cross-sectional-analysis-of-474-patients-attending-timor-leste-s-first-cardiology-service
#17
Elizabeth D Paratz, Noel Bayley
BACKGROUND: East Timor is a developing country and close neighbour of Australia. The prevalence of cardiac disease is unknown. AIMS: To describe the prevalence and patterns of cardiac disease in patients attending the first cardiology service of Timor-Leste. METHODS: A cross-sectional retrospective analysis was performed of demographic and clinical data of 474 unique patients referred to outpatient cardiology clinics conducted in East Timor from 2003-2016...
February 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28145035/the-epidemiology-of-long-stay-patients-in-a-university-teaching-hospital
#18
Kim O'Sullivan, Johan Martensson, Raymond Robbins, K J Farley, Doug Johnson, Daryl Jones
BACKGROUND: Patients admitted to acute care hospitals may have multiple co-morbidities, and a small proportion may stay a protracted period. AIMS: To assess the proportion of hospital patients who are long stay (≥14 days), evaluate associations with baseline variables and subsequent in-patient morbidity and mortality. METHODS: Retrospective observational study of patients aged ≥ 18 years staying in hospital for at least 24 hr between 1-7-2013 and 30-6-2014...
February 1, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28105778/psychosocial-screening-and-management-of-young-people-aged-18-25-years-with-diabetes
#19
Helen d'Emden, Brett McDermott, Neisha D'Silva, Tom Dover, Tatjana Ewais, Kristen Gibbons, Trisha O'Moore-Sullivan
BACKGROUND: Routine psychosocial screening and management of people with diabetes is recommended. AIMS: To profile demographic, medical and psychosocial characteristics of young people with diabetes, and to develop a screening tool and care pathway for routine use. METHODS: Indices of diabetes control and recorded diabetes complications were complimented by psychosocial screening tools assessing psychological, diabetes specific, and perceived stress (K10, PAID, PSS), well-being (WHO-5), disordered eating ((EDI-3RC), compensatory behaviour questionnaire, social support (MSPSS), resilience (CD-2) and financial concerns...
January 20, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28105777/lung-cancer-and-socio-economic-status-inextricably-linked-to-place-of-residence
#20
E J Denton, D Hart, P A Russell, G Wright, M Conron
BACKGROUND: The association between socioeconomic status (SES) and lung cancer is internationally established but in Australia this relationship remains ill defined. AIMS: To examine the association between SES, place of residence and lung cancer outcomes in a large Australian cohort. METHODS: 2369 consecutive lung cancer patients managed by St Vincent's Hospital lung multidisciplinary meeting between 2001-2014 were included. Postcode data stratified participants by Socio-Economic Indexes for Areas, a validated measure of SES, and by geographical location, an important socioeconomic factor in Australia...
January 20, 2017: Internal Medicine Journal
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