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JOP: Journal of the Pancreas

Jason A Adler, Muhammad W Saif
Introduction: Drug-induced exanthems are commonly associated with NSAIDs, antibiotics, and anti-epileptics. Pancrelipase is frequently used for conditions resulting in pancreatic exocrine insufficiency. Published case reports of pancrelipase hypersensitivity focus on the respiratory manifestations. Case Report: Here we report a case of skin hypersensitivity resulting from pancrelipase use. To further assess this association, we used a Naranjo nomogram, which determines the likelihood that an adverse drug reaction is the result of the drug itself...
September 2018: JOP: Journal of the Pancreas
Rohit Dhingra, Julie Y Tse, Muhammad Wasif Saif
Background: Gastroenteropancreatic neuroendocrine tumors are neoplasms commonly found within the gastrointestinal tract that originate from endocrine cells. These are slow progressive tumors and often metastasize to other elements of the gastrointestinal tract including the liver. Consequently, these tumors release hormones including serotonin and/or histamine that are responsible for the symptoms including intermittent flushing and diarrhea. Metastasis of gastroenteropancreatic neuroendocrine tumors, although rare, is possible and may extend to local lymph nodes and viscera...
September 2018: JOP: Journal of the Pancreas
Muhammad Wasif Saif
No abstract text is available yet for this article.
May 2018: JOP: Journal of the Pancreas
Brandon C Chapman, Ana Gleisner, Devin Rigg, Wells Messersmith, Alessandro Paniccia, Cheryl Meguid, Csaba Gajdos, Martin D McCarter, Richard D Schulick, Barish H Edil
Context: Neoadjuvant chemotherapy is increasingly used in borderline resectable and locally advanced pancreatic cancer to facilitate surgical resection. Objective: To compare progression free survival and overall survival in patients receiving neoadjuvant FOLFIRINOX with those receiving gemcitabine/abraxane. Design: Retrospective cohort study. Setting: University of Colorado Hospital from 2012-2016. Participants: Patients with pancreatic adenocarcinoma...
March 2018: JOP: Journal of the Pancreas
Muhammad Wasif Saif
No abstract text is available yet for this article.
November 2017: JOP: Journal of the Pancreas
Noor-L-Houda Bekkali, Tom Thomas, Margaret Geraldine Keane, Sam Murray, Deepak Joshi, Ghassan Elsayed, Gavin James Johnson, Michael Huw Chapman, Stephen Paul Pereira, George John Mitchell Webster
Background: Rectal non-steroidal anti-inflammatory drug at endoscopic retrograde cholangiopancreatography is now the standard of care to reduce the risk of post-ERCP pancreatitis. Pancreatic duct stenting also reduces the risk of post- ERCP pancreatitis in high-risk patients, but failed pancreatic duct stenting carries an increased PEP rate (up to 35%). Study Aim: To assess the impact on post-ERCP pancreatitis of successful and unsuccessful pancreatic duct stent placement in the setting of universal rectal non-steroidal anti-inflammatory drug use...
July 2017: JOP: Journal of the Pancreas
Amrit K Kamboj, John M Dewitt, Rohan M Modi, Darwin L Conwell, Somashekar G Krishna
Intraductal papillary mucinous neoplasms are classified into gastric, intestinal, pancreatobiliary, and oncocytic subtypes where morphology portends disease prognosis. The study aim was to demonstrate EUS-guided needle-based confocal laser endomicroscopy imaging features of intraductal papillary mucinous neoplasm subtypes. Four subjects, each with a specific intraductal papillary mucinous neoplasm subtype were enrolled. An EUS-guided needle-based confocal laser endomicroscopy miniprobe was utilized for image acquisition...
May 2017: JOP: Journal of the Pancreas
Mikram Jafri, Amit Sachdev, Javed Sadiq, David Lee, Ting Taur, Adam Goodman, Frank Gress
BACKGROUND: Endotherapy is a treatment modality that can be used to manage the pain associated with chronic pancreatitis. The aim of this systematic review and meta-analysis is to evaluate the efficacy of endotherapy in the management of pain associated with chronic pancreatitis. METHODS: A search of Medline, Pubmed, and Embase databases between 1988 to December 2014 was conducted to evaluate the use of endotherapy for pain relief in patients with chronic pancreatitis...
March 2017: JOP: Journal of the Pancreas
Ahmad Malli, Feng Li, Darwin L Conwell, Zobeida Cruz-Monserrate, Hisham Hussan, Somashekar G Krishna
Obesity is a global epidemic as recognized by the World Health Organization. Obesity and its related comorbid conditions were recognized to have an important role in a multitude of acute, chronic, and critical illnesses including acute pancreatitis, nonalcoholic fatty pancreas disease, and pancreatic cancer. This review summarizes the impact of adiposity on a spectrum of pancreatic diseases.
2017: JOP: Journal of the Pancreas
Mikram Jafri, Amit H Sachdev, Lauren Khanna, Frank G Gress
BACKGROUND: Endoscopic ultrasound guided elastography is an imaging modality that can be used to evaluate tissue stiffness and to assess solid pancreatic lesions. It can also assist in optimizing the diagnostic yield of endoscopic ultrasound guided fine needle aspiration biopsies. AIMS: To review the literature on solid pancreatic lesions, the use of EUS guided fine needle aspiration and endoscopic ultrasound guided elastography and to present a single center experience using elastography to direct fine needle aspiration biopsies of solid pancreatic lesions...
September 2016: JOP: Journal of the Pancreas
Andre De Souza, Khawaja Irfan, Faisal Masud, Muhammad Wasif Saif
Pancreatic Cancer is the fourth cause of cancer-related deaths in the United States. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent literature suggests that diabetes mellitus type 2 is a risk factor, a manifestation and a prognostic factor for pancreatic cancer. This article is intended to clarify the evidence about diabetes as a risk factor for pancreatic cancer.
March 2016: JOP: Journal of the Pancreas
Hisanori Umehara, Mitsuhiro Kawano
No abstract text is available yet for this article.
March 20, 2015: JOP: Journal of the Pancreas
Daniele De Nuzzo, Alessia Miconi, Paola Pierantognetti
No abstract text is available yet for this article.
March 20, 2015: JOP: Journal of the Pancreas
Dana M Christopher, Kimberly J Chaput, Kimberly J Fairley, Andrew D Mowery, Christopher Valente, Blake A Stewart, Steven R Bonebrake, Harshit Khara, Amitpal S Johal
No abstract text is available yet for this article.
March 20, 2015: JOP: Journal of the Pancreas
Xing Wang, Xubao Liu
No abstract text is available yet for this article.
March 20, 2015: JOP: Journal of the Pancreas
Xing Wang, Yong-Hua Chen, Yun-Qiang Cai, Xu-Bao Liu
CONTEXT: Undifferentiated (spindle cell) carcinomas of the pancreas are rare anaplastic variants of pancreatic ductal adenocarcinoma with a frequency of 2% of pancreatic exocrine tumors. Their clinicopathological features are limited and obtained by few previously case reports. We report a case of undifferentiated pancreatic carcinoma with a rare focal osteochondroid differentiation. CASE REPORT: A sixty-six-year-old woman was admitted to our hospital for abdominal pain and nonspecific nausea for almost 40 days...
March 20, 2015: JOP: Journal of the Pancreas
Maximilian Tiller, Felix Gundling, Wolfgang Schepp, Martin Fuchs
CONTEXT: Pancreatic adenocarcinoma is one of the most lethal malignancies worldwide. In patients with unresectable tumor there are several strategies of palliative chemotherapy, either gemcitabine based regimens or FOLFIRINOX, which is supposed to be most efficient but also most toxic. Hence, management of toxicity is crucial to perform a therapy consisting of FOLFIRINOX. CASE REPORT: We report on a 69-year-old female patient suffering from adenocarcinoma of the pancreatic tail with multiple liver metastases...
March 20, 2015: JOP: Journal of the Pancreas
Animesh A Singla, Francis Ting, Apresh Singla
CONTEXT: The triad of acute pancreatitis, hypertriglyceridemia and diabetes is a rare occurrence. CASE REPORT: A previously well 19-year-old male presented to the emergency department with 24-hour history of epigastric pain, associated with polyuria and nausea. Biochemical markers showed the presence of hyperglycemia (blood sugar level 15 mmol/L) and ketonemia (5.3 mmol/L). Further investigation revealed severe hypertriglyceridemia (4,009 mg/dL) and elevated lipase (1,714 U/L)...
March 20, 2015: JOP: Journal of the Pancreas
Ayorinde Ogunbameru, Mohammed Jandali, Amer Issa, Waleed Quwatli, Timothy Woodlock, Wajid Choudhry
CONTEXT: Levamisole-contaminated cocaine is an increasingly reported cause of vasculitis and immunologic abnormalities in cocaine abusers. The systemic effects of vasculitis are commonly seen in the dermatologic, hematologic and renal systems but rarely the gastrointestinal system. CASE REPORT: We present an atypical case of cocaine-induced vasculitis presenting initially as an acute pancreatitis and then rapidly progressing to involve multi-organ systems over the next couple of weeks...
March 2015: JOP: Journal of the Pancreas
Anupam Lal, Santhosh Kumar Pavunesan, Harshavardhan Mahalingam, Mandeep Garg, Saroj K Sinha, Niranjan Khandelwal
CONTEXT: Agenesis of the dorsal pancreas is a rare congenital anomaly which can be detected either incidentally during imaging or encountered during investigation for pancreas related pathologies such as pancreatitis or diabetes mellitus. Few associations of this condition with heterotaxy syndrome, pancreatic tumors and congenital heart disease have been described. CASE REPORT: We report a novel association of genitourinary anomalies in a case of complete dorsal pancreatic agenesis not previously described in the literature...
March 20, 2015: JOP: Journal of the Pancreas
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