journal
MENU ▼
Read by QxMD icon Read
search

Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG

journal
https://www.readbyqxmd.com/read/30429697/severe-neuropathic-pain-with-concomitant-administration-of-vincristine-and-posaconazole
#1
Mark John-Yung Lin, Megan Rose Paul, Dennis John Kuo
Vincristine is a chemotherapeutic agent with a potential toxicity of sensorimotor peripheral neuropathy. Patients receiving chemotherapy are in an immunocompromised state and may require antifungal agents. Triazole antifungals are known inhibitors of cytochrome P450 (CYP) enzymes. Vincristine is a known CYP3A4 and CYP3A5 substrate, and concomitant administration with fluconazole or voriconazole has been reported to increase vincristine toxicity and peripheral neuropathy, but there is limited literature on posaconazole in this regard...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429696/assessment-of-outcomes-with-a-sedation-protocol-during-laser-photocoagulation-in-preterm-infants-with-retinopathy-of-prematurity
#2
Jennifer F Dannelley, Peter N Johnson, Michael P Anderson, Kari Oestreich, R Michael Siatkowski, Jamie L Miller
OBJECTIVES: To evaluate the success of a sedation protocol of fentanyl and midazolam infusions for infants undergoing laser photocoagulation for retinopathy of prematurity. METHODS: This retrospective study included infants receiving a sedation protocol for laser photocoagulation during a 4-year period. The primary objective was protocol success, defined as completion without interruption, absence of protocol dose deviations, and absence of interventions. Secondary objectives compared outcomes between those with and without opioid/benzodiazepine exposure...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429695/effectiveness-of-antimicrobial-preservation-of-extemporaneous-diluted-simple-syrup-vehicles-for-pediatrics
#3
Ana Santoveña-Estévez, Javier Suárez-González, Martín Vera, Cristina González-Martín, Mabel Soriano, José B Fariña
OBJECTIVES: Extemporaneous or magistral formulation of active pharmaceutical ingredients using traditional compounding techniques is a common practice when no commercial form is available for pediatrics. For this vulnerable group of patients, the formulation must be prepared with the minimum quantity and lowest proportion of excipients approved for pediatrics, avoiding the use of preservatives. Often the vehicles used for these preparations are dilutions of simple syrup with water. The objective of this study is to assess the effectiveness of antimicrobial preservation in simple syrup diluted with aqua conservans (conserved water), without propylene glycol or with a reduced proportion of parabens...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429694/use-of-intravenous-acetaminophen-in-children-for-analgesia-after-spinal-fusion-surgery-a-randomized-clinical-trial
#4
Nicole Rizkalla, Nicole R Zane, Janice L Prodell, Okan U Elci, Lynne G Maxwell, Mary Ann DiLiberto, Athena F Zuppa
OBJECTIVES: Opioid pharmacotherapy is the cornerstone of postoperative analgesia. Despite its effectiveness, it has a variety of potential adverse effects. Therefore, a multimodal approach with non-opioid analgesics would be optimal. The aim of this study was to determine if intravenous (IV) acetaminophen would reduce opioid requirements and improve clinical outcomes in children after surgery. METHODS: A single-center, randomized, double-blind study was conducted in 57 children (10-18 years old) undergoing posterior spine fusion surgery between July 2011 to May 2014...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429693/azithromycin-induces-migrating-motor-complexes-in-pediatric-patients-undergoing-antroduodenal-motility-studies
#5
Asiya K Shakir, Muhammad Adnan Altaf
OBJECTIVE: Erythromycin (ERY) is used in the treatment of gastroparesis; however, this medication is associated with serious side effects, such as cardiac arrhythmias and consequent cardiorespiratory arrest. Azithromycin (AZM) has been suggested as an alternative to ERY as a result of its improved safety profile. Intravenous ERY (1 mg/kg) is administered during antroduodenal motility studies to induce migrating motor complexes (MMCs), the presence or absence of which helps diagnose motility disorders like gastroparesis and gastrointestinal dysmotility...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429692/relationship-of-pulmonary-outcomes-microbiology-and-serum-antibiotic-concentrations-in-cystic-fibrosis-patients
#6
Andrea Hahn, Caroline Jensen, Hani Fanous, Hollis Chaney, Iman Sami, Geovanny F Perez, Stan Louie, Anastassios C Koumbourlis, James E Bost, John N van den Anker
OBJECTIVES: To determine the frequency of subtherapeutic exposure to intravenously administered β-lactam antibiotics in a cohort of cystic fibrosis (CF) patients who were treated for a pulmonary exacerbation, and its impact on pulmonary function. METHODS: Nineteen CF patients between the ages of 5 and 21 years treated at Children's National Health System for a pulmonary exacerbation were followed between March 2015 and August 2016 in a prospective, longitudinal study...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429691/pediatric-antiviral-stewardship-defining-the-potential-role-of-ribavirin-in-respiratory-syncytial-virus-associated-lower-respiratory-illness
#7
Jessica Hoover, Shannan Eades, Weng Man Lam
OBJECTIVES: Although no longer included in the American Academy of Pediatrics guideline, ribavirin was shown to be beneficial in a subset of adult patients with severe respiratory syncytial virus (RSV)-associated bronchiolitis. This study aimed to investigate risk factors for progression to severe acute respiratory tract infections in hospitalized pediatric patients with RSV-associated bronchiolitis to identify which patients may benefit from inhaled ribavirin therapy, despite its substantial cost, diffcult administration, and potential complications...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429690/poractant-alfa-versus-beractant-for-neonatal-respiratory-distress-syndrome-a-retrospective-cost-analysis
#8
Sara Brown, Jeff Hurren, Heidi Sartori
OBJECTIVES: The objectives of this study were to determine the average medication cost per patient of poractant alfa and beractant, and to compare the outcomes of treatment with these agents. METHODS: We conducted a retrospective, observational, cohort study of patients who received surfactant, before and after an institutional formulary change from beractant to poractant alfa. The primary outcome was the average medication cost per case. Secondary measures were clinical outcomes, including duration of respiratory support, length of hospital stay, and the occurrence of complications...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429689/assessing-the-understanding-of-pediatric-oriented-medication-education-materials-versus-standard-available-education-materials
#9
Jessica M Biggs, Nicole E Glasgow, Francoise Pradel, Jill A Morgan
OBJECTIVES: The objective of this study was to determine if education material targeting children would improve understanding of medication indication, administration, and common side effects in pediatric subjects. METHODS: This cross-sectional pilot study included students 7 to 11 years old from a suburban elementary school. Study participants were read either the US Food and Drug Administration-approved adult medication leaflet or a pediatric medication leaflet created at a first-grade reading level for levetiracetam (Keppra, UCB, Inc, Atlanta, GA)...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30429688/evolving-pharmacotherapeutic-strategies-for-type-1-diabetes-mellitus
#10
REVIEW
Samie Sabet, Michelle E Condren, Angela F Boston, Lauren C Doak, Laura J Chalmers
Despite pharmacotherapeutic advancements in the management of type 1 diabetes mellitus during the past several decades, patients struggle to achieve glycemic goals. Additionally, hypoglycemia, especially in extremes of age, decreases quality of life. The lack of optimal glycemic control and risk for hypoglycemia are multifactorial. Nevertheless, endeavors aiming to develop pharmacotherapeutic options with enhanced pharmacokinetic, pharmacodynamic, and clinical profiles continue. This review article discusses recent ventures in 3 categories of insulin, non-insulin, and glucagon products...
September 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181728/pediatric-news
#11
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181727/position-paper-pharmacists-and-childhood-vaccines
#12
Rachel Meyers, JoEllen Weilnau, Amy Holmes, Jennifer E Girotto
Vaccination rates of children in the United States remain below the target coverage levels identified in the Healthy People 2020 objectives. Given the success of pharmacists in providing adult vaccinations and the accessibility of pharmacists to the public, expanding pharmacists' authority to vaccinate children may improve vaccination rates of children, particularly in key disease states. This article serves as a Position Statement of the Pediatric Pharmacy Advocacy Group (PPAG), who supports the expansion of pharmacists' authority to vaccinate children...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181726/intravenous-ribavirin-for-parainfluenza-and-respiratory-syncytial-virus-in-an-infant-receiving-extracorporeal-membrane-oxygenation-and-continuous-renal-replacement-therapy
#13
Cheryl L Sargel, Mohammed Aboud, Aimee Forster, Loralie J Langman, Jessica Tansmore, Bruce A Mueller, William E Smoyer, Jeffery J Auletta
BACKGROUND: Viral bronchiolitis remains a significant cause of hospitalization as well as morbidity and mortality during the first year of life, with treatment options beyond supportive care being limited. In cases of severe illness, ribavirin may offer therapeutic benefit. OBJECTIVE: We report the use of intravenous (IV) ribavirin in an infant requiring concomitant venovenous extracorporeal membrane oxygenation (VV-ECMO) and continuous venovenous hemofiltration (CVVH) for respiratory syncytial virus (RSV) and parainfluenza virus (PIV) coinfection...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181725/impact-of-two-educational-modules-on-practitioner-knowledge-of-pediatric-delirium
#14
Allyson D Gabbard, Leslie K Patatanian
OBJECTIVES: The purpose of this study was to evaluate the efficacy of education modules in preparing staff before the implementation of a pediatric delirium screening protocol. METHODS: After consenting participants began phase 1 of the study, which covered general information on pediatric delirium. It comprised a 21-question assessment administered as a pretest followed by an education module and then the same 21-question assessment administered as a posttest. After completing phase 1, participants proceeded to phase 2, which focused on use of the Cornell Assessment of Pediatric Delirium (CAPD) tool...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181724/development-of-an-interprofessional-pharmacist-nurse-navigation-pediatric-discharge-program
#15
Vy Nguyen, Danielle Altares Sarik, Michael C Dejos, Elora Hilmas
OBJECTIVES: Numerous challenges face clinically complex patients as they transition from hospital to home. The purpose of this project was to add pharmacy discharge services to an existing nurse-led discharge service (patient navigation program) to facilitate the transition of care process for clinically complex pediatric patients. METHODS: For select patients referred to the service, a pharmacist resolved medication discrepancies, provided discharge counseling, and conducted follow-up telephone encounters on days 1, 7, and 14 post discharge...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181723/effect-of-exogenous-antithrombin-administration-on-anti-xa-levels-in-infants-treated-with-enoxaparin
#16
Brittany B Logston, Emily A Rodman, Kimberly L Dinh, Jennifer L Placencia, Brady S Moffett, Danielle R Rios
OBJECTIVES: Determine the effect of exogenous antithrombin III administration on low molecular weight heparin anti-Xa levels in the context of enoxaparin dosing in infants. METHODS: A retrospective chart review of infants receiving concomitant antithrombin III and enoxaparin. The primary objective of this study was to determine the median change in anti-Xa level with antithrombin III supplementation. Secondary objectives were to analyze the median change in antithrombin III levels after administration of exogenous antithrombin III, the dosing of antithrombin III, and the dose of enoxaparin throughout therapy...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181722/sterility-duration-of-preprimed-extracorporeal-membrane-oxygenation-circuits
#17
Vi Ean Tan, Alan T Evangelista, Dominick M Carella, Daniel Marino, Wayne S Moore, Nadji Gilliam, Arun Chopra, Jeffrey J Cies
OBJECTIVES: There is a lack of standardization and supporting data regarding the duration preassembled and preprimed extracorporeal membrane oxygenation (ECMO) circuits are expected to be sterile. Therefore, the purpose of this study was to prospectively evaluate whether preassembled and preprimed ECMO circuits could maintain sterility for a period up to 65 days. DESIGN: Four ECMO circuits (2 neonatal/pediatric¼" and 2 adolescent/adult ⅜ ") were assembled and primed under sterile conditions and maintained at room temperature...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181721/therapeutic-drug-monitoring-of-vancomycin-in-pediatric-patients-with-extracorporeal-membrane-oxygenation-support
#18
Brenda L Zylbersztajn, Giannina Izquierdo, Roxana C Santana, Christian Fajardo, Juan P Torres, Jaime Cordero, Cristián Valverde
OBJECTIVES: Determine pharmacokinetic (PK) parameters and optimal dosage of vancomycin for children on extracorporeal membrane oxygenation (ECMO). METHODS: Retrospective PK study of vancomycin in pediatric patients on ECMO who received IV vancomycin 40 to 60 mg/kg/day every 6 hours. Patients were analyzed according to the presence of acute kidney injury (AKI) and requirement of renal replacement therapy (RRT). RESULTS: Data from 40 children, with a median age of 2...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181720/a-report-of-an-asthma-pathway-leading-to-improved-resource-use
#19
Andy L Nian, Russell J Orr, Sangeeta K Schroeder
OBJECTIVES: Asthma pathways have been shown to improve resource use and decrease length of stay (LOS). A tertiary care hospital implemented an asthma pathway in May 2015 to standardize inpatient care. We predicted that the pathway would increase the use of albuterol metered-dose inhalers (MDIs) and steroids; decrease use of albuterol nebulizer, antibiotics, chest radiograph (CXR), and respiratory viral panel (RVP); and decrease LOS. METHODS: This retrospective cohort study selected patients between the ages of 2 and 18 years who were admitted for asthma as a primary diagnosis between May 2014 and May 2016 (1 year preimplementation to 1 year postimplementation)...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181719/pharmacist-and-pediatrician-knowledge-of-codeine-use-in-children
#20
Ting He, Allison B Lardieri, Jill A Morgan
OBJECTIVES: In 2011, approximately 1.7 million pediatric patients had a codeine-containing prescription filled at a US retail pharmacy. Numerous cases involving serious adverse effects or fatalities have been reported in children who have been prescribed codeine. In 2013, the US Food and Drug Administration added a boxed warning to avoid codeine in children after a tonsillectomy. The purpose of this study is to determine pharmacists' and pediatricians' knowledge of the boxed warning for codeine in children...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
journal
journal
39244
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"