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Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG

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https://www.readbyqxmd.com/read/30181728/pediatric-news
#1
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181727/position-paper-pharmacists-and-childhood-vaccines
#2
Rachel Meyers, JoEllen Weilnau, Amy Holmes, Jennifer E Girotto
Vaccination rates of children in the United States remain below the target coverage levels identified in the Healthy People 2020 objectives. Given the success of pharmacists in providing adult vaccinations and the accessibility of pharmacists to the public, expanding pharmacists' authority to vaccinate children may improve vaccination rates of children, particularly in key disease states. This article serves as a Position Statement of the Pediatric Pharmacy Advocacy Group (PPAG), who supports the expansion of pharmacists' authority to vaccinate children...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181726/intravenous-ribavirin-for-parainfluenza-and-respiratory-syncytial-virus-in-an-infant-receiving-extracorporeal-membrane-oxygenation-and-continuous-renal-replacement-therapy
#3
Cheryl L Sargel, Mohammed Aboud, Aimee Forster, Loralie J Langman, Jessica Tansmore, Bruce A Mueller, William E Smoyer, Jeffery J Auletta
BACKGROUND: Viral bronchiolitis remains a significant cause of hospitalization as well as morbidity and mortality during the first year of life, with treatment options beyond supportive care being limited. In cases of severe illness, ribavirin may offer therapeutic benefit. OBJECTIVE: We report the use of intravenous (IV) ribavirin in an infant requiring concomitant venovenous extracorporeal membrane oxygenation (VV-ECMO) and continuous venovenous hemofiltration (CVVH) for respiratory syncytial virus (RSV) and parainfluenza virus (PIV) coinfection...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181725/impact-of-two-educational-modules-on-practitioner-knowledge-of-pediatric-delirium
#4
Allyson D Gabbard, Leslie K Patatanian
OBJECTIVES: The purpose of this study was to evaluate the efficacy of education modules in preparing staff before the implementation of a pediatric delirium screening protocol. METHODS: After consenting participants began phase 1 of the study, which covered general information on pediatric delirium. It comprised a 21-question assessment administered as a pretest followed by an education module and then the same 21-question assessment administered as a posttest. After completing phase 1, participants proceeded to phase 2, which focused on use of the Cornell Assessment of Pediatric Delirium (CAPD) tool...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181724/development-of-an-interprofessional-pharmacist-nurse-navigation-pediatric-discharge-program
#5
Vy Nguyen, Danielle Altares Sarik, Michael C Dejos, Elora Hilmas
OBJECTIVES: Numerous challenges face clinically complex patients as they transition from hospital to home. The purpose of this project was to add pharmacy discharge services to an existing nurse-led discharge service (patient navigation program) to facilitate the transition of care process for clinically complex pediatric patients. METHODS: For select patients referred to the service, a pharmacist resolved medication discrepancies, provided discharge counseling, and conducted follow-up telephone encounters on days 1, 7, and 14 post discharge...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181723/effect-of-exogenous-antithrombin-administration-on-anti-xa-levels-in-infants-treated-with-enoxaparin
#6
Brittany B Logston, Emily A Rodman, Kimberly L Dinh, Jennifer L Placencia, Brady S Moffett, Danielle R Rios
OBJECTIVES: Determine the effect of exogenous antithrombin III administration on low molecular weight heparin anti-Xa levels in the context of enoxaparin dosing in infants. METHODS: A retrospective chart review of infants receiving concomitant antithrombin III and enoxaparin. The primary objective of this study was to determine the median change in anti-Xa level with antithrombin III supplementation. Secondary objectives were to analyze the median change in antithrombin III levels after administration of exogenous antithrombin III, the dosing of antithrombin III, and the dose of enoxaparin throughout therapy...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181722/sterility-duration-of-preprimed-extracorporeal-membrane-oxygenation-circuits
#7
Vi Ean Tan, Alan T Evangelista, Dominick M Carella, Daniel Marino, Wayne S Moore, Nadji Gilliam, Arun Chopra, Jeffrey J Cies
OBJECTIVES: There is a lack of standardization and supporting data regarding the duration preassembled and preprimed extracorporeal membrane oxygenation (ECMO) circuits are expected to be sterile. Therefore, the purpose of this study was to prospectively evaluate whether preassembled and preprimed ECMO circuits could maintain sterility for a period up to 65 days. DESIGN: Four ECMO circuits (2 neonatal/pediatric¼" and 2 adolescent/adult ⅜ ") were assembled and primed under sterile conditions and maintained at room temperature...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181721/therapeutic-drug-monitoring-of-vancomycin-in-pediatric-patients-with-extracorporeal-membrane-oxygenation-support
#8
Brenda L Zylbersztajn, Giannina Izquierdo, Roxana C Santana, Christian Fajardo, Juan P Torres, Jaime Cordero, Cristián Valverde
OBJECTIVES: Determine pharmacokinetic (PK) parameters and optimal dosage of vancomycin for children on extracorporeal membrane oxygenation (ECMO). METHODS: Retrospective PK study of vancomycin in pediatric patients on ECMO who received IV vancomycin 40 to 60 mg/kg/day every 6 hours. Patients were analyzed according to the presence of acute kidney injury (AKI) and requirement of renal replacement therapy (RRT). RESULTS: Data from 40 children, with a median age of 2...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181720/a-report-of-an-asthma-pathway-leading-to-improved-resource-use
#9
Andy L Nian, Russell J Orr, Sangeeta K Schroeder
OBJECTIVES: Asthma pathways have been shown to improve resource use and decrease length of stay (LOS). A tertiary care hospital implemented an asthma pathway in May 2015 to standardize inpatient care. We predicted that the pathway would increase the use of albuterol metered-dose inhalers (MDIs) and steroids; decrease use of albuterol nebulizer, antibiotics, chest radiograph (CXR), and respiratory viral panel (RVP); and decrease LOS. METHODS: This retrospective cohort study selected patients between the ages of 2 and 18 years who were admitted for asthma as a primary diagnosis between May 2014 and May 2016 (1 year preimplementation to 1 year postimplementation)...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181719/pharmacist-and-pediatrician-knowledge-of-codeine-use-in-children
#10
Ting He, Allison B Lardieri, Jill A Morgan
OBJECTIVES: In 2011, approximately 1.7 million pediatric patients had a codeine-containing prescription filled at a US retail pharmacy. Numerous cases involving serious adverse effects or fatalities have been reported in children who have been prescribed codeine. In 2013, the US Food and Drug Administration added a boxed warning to avoid codeine in children after a tonsillectomy. The purpose of this study is to determine pharmacists' and pediatricians' knowledge of the boxed warning for codeine in children...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/30181718/a-clinician-s-guide-to-oral-extended-release-drug-delivery-systems-in-epilepsy
#11
REVIEW
James W Wheless, Stephanie J Phelps
Epilepsy is one of the most common chronic neurologic disorders that affects individuals of all ages. It is primarily managed with antiepileptic drugs (AEDs), with the goal of maintaining complete seizure control combined with minimal or no adverse effects. Oral administration is the mainstay of AED delivery for patients with chronic epilepsy and consists essentially of immediate-release (IR) and modified-release (delayed-release and extended-release [ER]) dosage formulations. Extended-release formulations (hydrophilic or hydrophobic matrix systems, reservoir systems, and osmotic-release systems) release a drug in a controlled manner during an extended period of time following administration...
July 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970981/pediatric-news
#12
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970980/dosing-for-fentanyl-infusion-in-obese-children-just-because-it-s-what-we-have-always-done-doesn-t-mean-it-is-right
#13
Sin Yin Lim, Sukyung Woo, Jamie L Miller, Teresa V Lewis, Emilie D Henry, Peter N Johnson
No abstract text is available yet for this article.
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970979/angioedema-associated-with-nebulized-recombinant-human-dnase-in-a-preterm-infant-case-report
#14
Dilek Kurnaz, Seda Yilmaz Semerci, Aslan Babayigit, Burcu Cebeci, Gokhan Buyukkale, Merih Cetinkaya
Pulmonary atelectasis leads to difficulties in weaning of the neonates from mechanical ventilation. The management of persistent atelectasis in neonates constitutes a common challenge for physicians. Several reports suggested Recombinant human DNase (rhDNase) as a beneficial therapy for neonates with persistent atelectasis by reducing mucous viscosity. No adverse effect associated with rhDNase treatment was reported in neonates. Herein, we report probable adverse reactions associated with rhDNase use in a preterm infant...
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970978/general-anesthesia-with-dexmedetomidine-and-remifentanil-in-a-neonate-during-oracotomy-and-resection-of-a-congenital-cystic-adenomatoid-malformation
#15
Ellise Cappuccio, Arlyne K Thung, Joseph D Tobias
Based on animal data, concern has been expressed regarding the potential deleterious neurocognitive effects of general anesthesia during infancy and early life. Although there are no definitive data to prove this effect, the neonatal period has been suggested to be the most vulnerable period. While various inhaled and intravenous anesthetic agents have been implicated, dexmedetomidine and the opioids may be devoid of such effects. However, there are limited data regarding the combination of these agents during neonatal surgery and anesthesia...
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970977/characterization-of-the-clinical-outcomes-with-cefepime-in-a-neonatal-intensive-care-unit-a-retrospective-cohort-study
#16
Chad A Knoderer, David M Kaylor, Meghan E Toth, Katherine M Malloy, Kristen R Nichols
OBJECTIVES: The objective of this study was to characterize clinical outcomes when cefepime was used in a neonatal intensive care population. METHODS: Data were extracted from the medical records of all full-term (40 weeks gestational age) patients up to 2 months of age and preterm patients up to 48 weeks postmenstrual age admitted to the neonatal intensive care unit (NICU) at a freestanding children's hospital between January 1, 2010, and December 31, 2013, who received at least 48 hours of cefepime...
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970976/effect-of-nursing-education-on-optimization-of-medication-reconciliation-in-the-pediatric-emergency-department
#17
Danielle McDonald, Rupal Mansukhani, Suzannah Kokotajlo, Frank Diaz, Christine Robinson
OBJECTIVE: This study was conducted to evaluate the impact of education on optimizing medication histories in a single-center pediatric emergency department. METHODS: This was a prospective, 2-phase study of 200 patients ages 21 years and younger who presented to the pediatric emergency department in January and February 2017. In phase I of the study, 100 patients were interviewed by both a nurse and a pharmacist. Between phases I and II, the pharmacist educated each nurse and disseminated standardized education materials...
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970975/pain-management-in-pediatric-chronic-kidney-disease
#18
REVIEW
Amanda Reis, Caitlyn Luecke, Thomas Keefe Davis, Aadil Kakajiwala
Pain is a common problem in children with chronic kidney disease (CKD); however, limited data exist regarding its management. Although most pain is managed pharmacologically, in some instances non-pharmacologic management can aid in safely ameliorating discomfort. Because of the accumulation of toxic metabolites, many common pain medications have adverse effects on kidney function or altered pharmacokinetics in the setting of CKD. Decreased clearance impacts safe dosing of analgesics. The pain management of patients on renal replacement therapy requires an understanding of drug clearance due to the different modalities of dialysis...
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29970974/ashp-ppag-guidelines-for-providing-pediatric-pharmacy-services-in-hospitals-and-health-systems
#19
Lea S Eiland, Kim Benner, Karl F Gumpper, Melissa K Heigham, Rachel Meyers, Katherine Pham, Amy L Potts
No abstract text is available yet for this article.
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29720922/pediatric-news
#20
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
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