journal
https://read.qxmd.com/read/26449218/hypoxia-mediated-pulmonary-edema-potential-influence-of-oxidative-stress-sympathetic-activation-and-cerebral-blood-flow
#21
JOURNAL ARTICLE
Shadi Khademi, Melinda A Frye, Kimberly M Jeckel, Thies Schroeder, Eric Monnet, Dave C Irwin, Patricia A Cole, Christopher Bell, Benjamin F Miller, Karyn L Hamilton
BACKGROUND: Neurogenic pulmonary edema (NPE) is a non-cardiogenic form of pulmonary edema that can occur consequent to central neurologic insults including stroke, traumatic brain injury, and seizure. NPE is a public health concern due to high morbidity and mortality, yet the mechanism(s) are unknown. We hypothesized that NPE, evoked by cerebral hypoxia in the presence of systemic normoxia, would be accompanied by sympathetic activation, oxidative stress, and compensatory antioxidant mechanisms...
October 9, 2015: BMC Physiology
https://read.qxmd.com/read/26040642/effects-of-postnatal-growth-restriction-and-subsequent-catch-up-growth-on-neurodevelopment-and-glucose-homeostasis-in-rats
#22
JOURNAL ARTICLE
Erica E Alexeev, Bo Lönnerdal, Ian J Griffin
BACKGROUND: There is increasing evidence that poor growth of preterm infants is a risk factor for poor long-term development, while the effects of early postnatal growth restriction are not well known. We utilized a rat model to examine the consequences of different patterns of postnatal growth and hypothesized that early growth failure leads to impaired development and insulin resistance. Rat pups were separated at birth into normal (N, n = 10) or restricted intake (R, n = 16) litters...
2015: BMC Physiology
https://read.qxmd.com/read/25971747/antenatal-maternal-low-protein-diet-ace-2-in-the-mouse-lung-and-sexually-dimorphic-programming-of-hypertension
#23
JOURNAL ARTICLE
Ravi Goyal, Jonathan Van-Wickle, Dipali Goyal, Lawrence D Longo
Elevated blood pressure is an important global health problem, and in-utero under-nutrition may be an important factor in the pathogenesis of hypertension. In the present study, we tested the hypothesis that antenatal maternal low protein diet (MLPD) leads to sexually dimorphic developmental programming of the components of the pulmonary renin-angiotensin system. This may be important in the antenatal MLPD-associated development of hypertension. In pregnant mice, we administered normal (control) and isocaloric 50% protein restricted diet, commencing one week before mating and continuing until delivery of the pups...
2015: BMC Physiology
https://read.qxmd.com/read/25888441/exercise-performed-around-mlss-decreases-systolic-blood-pressure-and-increases-aerobic-fitness-in-hypertensive-rats
#24
JOURNAL ARTICLE
Bernardo A Petriz, Jeeser A Almeida, Clarissa P C Gomes, Carlos Ernesto, Rinaldo W Pereira, Octavio L Franco
BACKGROUND: Exercise is a non-pharmacologic agent widely used for hypertension control, where low intensity is often associated with blood pressure reduction. Maximal lactate steady state (MLSS) was recently identified in spontaneously hypertensive rats (SHRs) as an important step in establishing secure intensities for prescribing exercise for hypertensive phenotypes. Here we verified the effects of training around MLSS, 20% below MLSS, and 15% above MLSS on aerobic fitness and blood pressure status of SHR...
2015: BMC Physiology
https://read.qxmd.com/read/25539668/alteration-in-circulating-metabolites-during-and-after-heat-stress-in-the-conscious-rat-potential-biomarkers-of-exposure-and-organ-specific-injury
#25
Danielle L Ippolito, John A Lewis, Chenggang Yu, Lisa R Leon, Jonathan D Stallings
BackgroundHeat illness is a debilitating and potentially life-threatening condition. Limited data are available to identify individuals with heat illness at greatest risk for organ damage. We recently described the transcriptomic and proteomic responses to heat injury and recovery in multiple organs in an in vivo model of conscious rats heated to a maximum core temperature of 41.8°C (Tc,Max). In this companion study, we examined changes in plasma metabolic networks at Tc,Max, 24, or 48 hours after the heat stress stimulus...
December 24, 2014: BMC Physiology
https://read.qxmd.com/read/25488103/acetate-transiently-inhibits-myocardial-contraction-by-increasing-mitochondrial-calcium-uptake
#26
JOURNAL ARTICLE
James F Schooley, Aryan M A Namboodiri, Rachel T Cox, Rolf Bünger, Thomas P Flagg
BACKGROUND: There is a close relationship between cardiovascular disease and cardiac energy metabolism, and we have previously demonstrated that palmitate inhibits myocyte contraction by increasing Kv channel activity and decreasing the action potential duration. Glucose and long chain fatty acids are the major fuel sources supporting cardiac function; however, cardiac myocytes can utilize a variety of substrates for energy generation, and previous studies demonstrate the acetate is rapidly taken up and oxidized by the heart...
December 9, 2014: BMC Physiology
https://read.qxmd.com/read/25487871/white-nose-syndrome-initiates-a-cascade-of-physiologic-disturbances-in-the-hibernating-bat-host
#27
JOURNAL ARTICLE
Michelle L Verant, Carol U Meteyer, John R Speakman, Paul M Cryan, Jeffrey M Lorch, David S Blehert
BACKGROUND: The physiological effects of white-nose syndrome (WNS) in hibernating bats and ultimate causes of mortality from infection with Pseudogymnoascus (formerly Geomyces) destructans are not fully understood. Increased frequency of arousal from torpor described among hibernating bats with late-stage WNS is thought to accelerate depletion of fat reserves, but the physiological mechanisms that lead to these alterations in hibernation behavior have not been elucidated. We used the doubly labeled water (DLW) method and clinical chemistry to evaluate energy use, body composition changes, and blood chemistry perturbations in hibernating little brown bats (Myotis lucifugus) experimentally infected with P...
December 9, 2014: BMC Physiology
https://read.qxmd.com/read/25399338/differential-role-of-stim1-and-stim2-during-transient-inward-t-in-current-generation-and-the-maturation-process-in-the-xenopus-oocyte
#28
JOURNAL ARTICLE
Barbara Serrano-Flores, Edith Garay, Francisco G Vázquez-Cuevas, Rogelio O Arellano
BACKGROUND: The Xenopus oocyte is a useful cell model to study Ca2+ homeostasis and cell cycle regulation, two highly interrelated processes. Here, we used antisense oligonucleotides to investigate the role in the oocyte of stromal interaction molecule (STIM) proteins that are fundamental elements of the store-operated calcium-entry (SOCE) phenomenon, as they are both sensors for Ca2+ concentration in the intracellular reservoirs as well as activators of the membrane channels that allow Ca2+ influx...
November 15, 2014: BMC Physiology
https://read.qxmd.com/read/25373613/longevity-of-daphnia-and-the-attenuation-of-stress-responses-by-melatonin
#29
JOURNAL ARTICLE
Anke Schwarzenberger, Mark Christjani, Alexander Wacker
BACKGROUND: The widespread occurrence of melatonin in prokaryotes as well as eukaryotes indicates that this indoleamine is considerably old. This high evolutionary age has led to the development of diverse functions of melatonin in different organisms, such as the detoxification of reactive oxygen species and anti-stress effects. In insects, i.e. Drosophila, the addition of melatonin has also been shown to increase the life span of this arthropod, probably by reducing age-related increasing oxidative stress...
November 6, 2014: BMC Physiology
https://read.qxmd.com/read/25185746/mapk-activated-protein-kinase-2-deficiency-causes-hyperacute-tumor-necrosis-factor-induced-inflammatory-shock
#30
JOURNAL ARTICLE
Benjamin Vandendriessche, An Goethals, Alba Simats, Evelien Van Hamme, Peter Brouckaert, Anje Cauwels
BACKGROUND: MAPK-activated protein kinase 2 (MK2) plays a pivotal role in the cell response to (inflammatory) stress. Among others, MK2 is known to be involved in the regulation of cytokine mRNA metabolism and regulation of actin cytoskeleton dynamics. Previously, MK2-deficient mice were shown to be highly resistant to LPS/d-Galactosamine-induced hepatitis. Additionally, research in various disease models has indicated the kinase as an interesting inhibitory drug target for various acute or chronic inflammatory diseases...
September 4, 2014: BMC Physiology
https://read.qxmd.com/read/25189710/impact-of-maternal-dietary-fat-supplementation-during-gestation-upon-skeletal-muscle-in-neonatal-pigs
#31
JOURNAL ARTICLE
Hernan P Fainberg, Kayleigh L Almond, Dongfang Li, Cyril Rauch, Paul Bikker, Michael E Symonds, Alison Mostyn
BACKGROUND: Maternal diet during pregnancy can modulate skeletal muscle development of the offspring. Previous studies in pigs have indicated that a fat supplemented diet during pregnancy can improve piglet outcome, however, this is in contrast to human studies suggesting adverse effects of saturated fats during pregnancy. This study aimed to investigate the impact of a fat supplemented (palm oil) "high fat" diet on skeletal muscle development in a porcine model. Histological and metabolic features of the biceps femoris muscle obtained from 7-day-old piglets born to sows assigned to either a commercial (C, n = 7) or to an isocaloric fat supplementation diet ("high fat" HF, n = 7) during pregnancy were assessed...
August 27, 2014: BMC Physiology
https://read.qxmd.com/read/24555524/kcnq1-5-kv7-1-5-potassium-channel-expression-in-the-adult-zebrafish
#32
JOURNAL ARTICLE
Calvin Wu, Kanishk Sharma, Kyle Laster, Mohamed Hersi, Christina Torres, Thomas J Lukas, Ernest J Moore
BACKGROUND: KCNQx genes encode slowly activating-inactivating K+ channels, are linked to physiological signal transduction pathways, and mutations in them underlie diseases such as long QT syndrome (KCNQ1), epilepsy in adults (KCNQ2/3), benign familial neonatal convulsions in children (KCNQ3), and hearing loss or tinnitus in humans (KCNQ4, but not KCNQ5). Identification of kcnqx potassium channel transcripts in zebrafish (Danio rerio) remains to be fully characterized although some genes have been mapped to the genome...
February 20, 2014: BMC Physiology
https://read.qxmd.com/read/25623799/alteration-in-circulating-metabolites-during-and-after-heat-stress-in-the-conscious-rat-potential-biomarkers-of-exposure-and-organ-specific-injury
#33
JOURNAL ARTICLE
Danielle L Ippolito, John A Lewis, Chenggang Yu, Lisa R Leon, Jonathan D Stallings
BACKGROUND: Heat illness is a debilitating and potentially life-threatening condition. Limited data are available to identify individuals with heat illness at greatest risk for organ damage. We recently described the transcriptomic and proteomic responses to heat injury and recovery in multiple organs in an in vivo model of conscious rats heated to a maximum core temperature of 41.8°C (Tc,Max). In this study, we examined changes in plasma metabolic networks at Tc,Max, 24, or 48 hours after the heat stress stimulus...
2014: BMC Physiology
https://read.qxmd.com/read/25515219/camkii-content-affects-contractile-but-not-mitochondrial-characteristics-in-regenerating-skeletal-muscle
#34
JOURNAL ARTICLE
Wouter Eilers, Richard T Jaspers, Arnold de Haan, Céline Ferrié, Paola Valdivieso, Martin Flück
BACKGROUND: The multi-meric calcium/calmodulin-dependent protein kinase II (CaMKII) is the main CaMK in skeletal muscle and its expression increases with endurance training. CaMK family members are implicated in contraction-induced regulation of calcium handling, fast myosin type IIA expression and mitochondrial biogenesis. The objective of this study was to investigate the role of an increased CaMKII content for the expression of the contractile and mitochondrial phenotype in vivo. Towards this end we attempted to co-express alpha- and beta-CaMKII isoforms in skeletal muscle and characterised the effect on the contractile and mitochondrial phenotype...
2014: BMC Physiology
https://read.qxmd.com/read/25496699/big-data-in-wildlife-research-remote-web-based-monitoring-of-hibernating-black-bears
#35
JOURNAL ARTICLE
Timothy G Laske, David L Garshelis, Paul A Iaizzo
BACKGROUND: Numerous innovations for the management and collection of "big data" have arisen in the field of medicine, including implantable computers and sensors, wireless data transmission, and web-based repositories for collecting and organizing information. Recently, human clinical devices have been deployed in captive and free-ranging wildlife to aid in the characterization of both normal physiology and the interaction of animals with their environment, including reactions to humans...
2014: BMC Physiology
https://read.qxmd.com/read/25488023/identification-of-novel-kirrel3-gene-splice-variants-in-adult-human-skeletal-muscle
#36
JOURNAL ARTICLE
Peter Joseph Durcan, Johannes D Conradie, Mari Van deVyver, Kathryn Helen Myburgh
BACKGROUND: Multiple cell types including trophoblasts, osteoclasts and myoblasts require somatic cell fusion events as part of their physiological functions. In Drosophila Melanogaster the paralogus type 1 transmembrane receptors and members of the immunoglobulin superfamily Kin of Irre (Kirre) and roughest (Rst) regulate myoblast fusion during embryonic development. Present within the human genome are three homologs to Kirre termed Kin of Irre like (Kirrel) 1, 2 and 3. Currently it is unknown if Kirrel3 is expressed in adult human skeletal muscle...
2014: BMC Physiology
https://read.qxmd.com/read/24946879/sympathoactivation-and-rho-kinase-dependent-baroreflex-function-in-experimental-renovascular-hypertension-with-reduced-kidney-mass
#37
JOURNAL ARTICLE
Rainer U Pliquett, Sebastian Benkhoff, Oliver Jung, Ralf P Brandes
BACKGROUND: Dysregulation of the autonomic nervous system is frequent in subjects with cardiovascular disease. The contribution of different forms of renovascular hypertension and the mechanisms contributing to autonomic dysfunction in hypertension are incompletely understood. Here, murine models of renovascular hypertension with preserved (2-kidneys-1 clip, 2K1C) and reduced (1-kidney-1 clip, 1K1C) kidney mass were studied with regard to autonomic nervous system regulation (sympathetic tone: power-spectral analysis of systolic blood pressure; parasympathetic tone: power-spectral analysis of heart rate) and baroreflex sensitivity of heart rate by spontaneous, concomitant changes of systolic blood pressure and pulse interval...
2014: BMC Physiology
https://read.qxmd.com/read/24678801/reductions-in-expression-of-growth-regulating-genes-in-skeletal-muscle-with-age-in-wild-type-and-myostatin-null-mice
#38
JOURNAL ARTICLE
Jennifer C Jones, Kellie A Kroscher, Anna C Dilger
BACKGROUND: Genes that decline in expression with age and are thought to coordinate growth cessation have been identified in various organs, but their expression in skeletal muscle is unknown. Therefore, our objective was to determine expression of these genes (Ezh2, Gpc3, Mdk, Mest, Mycn, Peg3, and Plagl1) in skeletal muscle from birth to maturity. We hypothesized that expression of these genes would decline with age in skeletal muscle but differ between sexes and between wild type and myostatin null mice...
2014: BMC Physiology
https://read.qxmd.com/read/24581386/cardiac-responses-to-elevated-seawater-temperature-in-atlantic-salmon
#39
JOURNAL ARTICLE
Sven Martin Jørgensen, Vicente Castro, Aleksei Krasnov, Jacob Torgersen, Gerrit Timmerhaus, Ernst Morten Hevrøy, Tom Johnny Hansen, Sissel Susort, Olav Breck, Harald Takle
BACKGROUND: Atlantic salmon aquaculture operations in the Northern hemisphere experience large seasonal fluctuations in seawater temperature. With summer temperatures often peaking around 18-20°C there is growing concern about the effects on fish health and performance. Since the heart has a major role in the physiological plasticity and acclimation to different thermal conditions in fish, we wanted to investigate how three and eight weeks exposure of adult Atlantic salmon to 19°C, previously shown to significantly reduce growth performance, affected expression of relevant genes and proteins in cardiac tissues under experimental conditions...
2014: BMC Physiology
https://read.qxmd.com/read/24410819/retraction-the-effect-of-marathon-on-mrna-expression-of-anti-apoptotic-and-pro-apoptotic-proteins-and-sirtuins-family-in-male-recreational-long-distance-runners
#40
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No abstract text is available yet for this article.
2014: BMC Physiology
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