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BMC Endocrine Disorders

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https://www.readbyqxmd.com/read/29783969/association-between-thyroid-hormones-and-the-components-of-metabolic-syndrome
#1
Jieun Jang, Youngsook Kim, Jaeyong Shin, Sang Ah Lee, Young Choi, Eun-Cheol Park
BACKGROUND: Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify whether significant correlations exist between thyroid hormone levels and components of the metabolic syndrome in the general population of Korea. METHODS: The data were collected from the sixth Korea National Health and Nutrition Examination Surveys from 2013 to 2015...
May 21, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29764441/case-report-identification-of-an-hnf1b-p-arg527gln-mutation-in-a-maltese-patient-with-atypical-early-onset-diabetes-and-diabetic-nephropathy
#2
Nikolai Paul Pace, Johann Craus, Alex Felice, Josanne Vassallo
BACKGROUND: The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity of the disease. In this report we describe a case of atypical non autoimmune diabetes associated with a damaging HNF1β mutation. This is distinguished by a number of uncharacteristic clinical features, including early-onset obesity, the absence of renal cysts and diabetic nephropathy...
May 15, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29747617/pheochromocytoma-as-a-rare-cause-of-hypertension-in-a-46-x-i-x-q10-turner-syndrome-a-case-report-and-literature-review
#3
Ji Yeon Shin, Bo Hyun Kim, Young Keum Kim, Tae Hwa Kim, Eun Heui Kim, Min Jin Lee, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, In Joo Kim
BACKGROUND: Cardiovascular disease (CVD) presents the most serious health problems and contributes to the increased mortality in young women with Turner syndrome. Arterial hypertension in Turner syndrome patients is significantly more prevalent than that in a general age-matched control group. The aetiology of hypertension in Turner syndrome varies, even in the absence of cardiac anomalies and obvious structural renal abnormalities. Pheochromocytoma is an extremely rare cause among various etiologies for hypertension in patients with Turner syndrome...
May 10, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29747616/association-of-retinol-binding-protein-4-and-transthyretin-with-triglyceride-levels-and-insulin-resistance-in-rural-thais-with-high-type-2-diabetes-risk
#4
Karunee Kwanbunjan, Pornpimol Panprathip, Chanchira Phosat, Noppanath Chumpathat, Naruemon Wechjakwen, Somchai Puduang, Ratchada Auyyuenyong, Ina Henkel, Florian J Schweigert
BACKGROUND: Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and type 2 diabetes mellitus. The objective of this study was to elucidate the relationship between RBP4, TTR, triglyceride (TG) and type 2 diabetes risk in rural Thailand. METHODS: We measured the serum RBP4, TTR, glucose, triglyceride and insulin levels, and glucose tolerance of 167 volunteers from Sung Noen District, Nakhon Ratchasima Province, Thailand...
May 10, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29739382/higher-serum-25-oh-d-level-is-associated-with-decreased-risk-of-impairment-of-glucose-homeostasis-data-from-southwest-china
#5
Danting Li, Haoche Wei, Hongmei Xue, Jieyi Zhang, Mengxue Chen, Yunhui Gong, Guo Cheng
BACKGROUND: Recent epidemiological studies have suggested inverse associations between vitamin D status and metabolic diseases including type 2 diabetes (T2DM). The aim of this study was to examine whether a higher serum 25-hydroxyvitamin D (25(OH)D) was associated with a more favorable glucose homeostasis among adults without diabetes in Southwest China. METHODS: Serum 25(OH)D concentration was measured in a cross-sectional sample of 1514 adults without diabetes aged 25-65 years recruited from Southwest China...
May 9, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29720169/atr-101-a-selective-acat1-inhibitor-decreases-acth-stimulated-cortisol-concentrations-in-dogs-with-naturally-occurring-cushing-s-syndrome
#6
Daniel K Langlois, Michele C Fritz, William D Schall, N Bari Olivier, Rebecca C Smedley, Paul G Pearson, Marc B Bailie, Stephen W Hunt
BACKGROUND: Cushing's syndrome in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. In both species, treatment of pituitary- and adrenal-dependent disease is met with limitations. ATR-101, a selective inhibitor of ACAT1 (acyl coenzyme A:cholesterol acyltransferase 1), is a novel small molecule therapeutic currently in clinical development for the treatment of adrenocortical carcinoma, congenital adrenal hyperplasia, and Cushing's syndrome in humans...
May 2, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29703198/a-novel-chimeric-cyp11b2-cyp11b1-combined-with-a-new-p-l340p-cyp11b1-mutation-in-a-patient-with-11ohd-case-report
#7
Lian Duan, Rufei Shen, Lingyu Song, Yong Liao, Hongting Zheng
BACKGROUND: 11β-Hydroxylase deficiency (11OHD) is a common form of congenital adrenal hyperplasia that has been shown to result from inactivating CYP11B1 mutations, and pathogenic CYP11B2/CYP11B1 chimeras contribute to a minority of cases. Heterozygote cases (chimeras combined with missense mutation) are very rare, and genetic analysis of these cases is difficult. CASE PRESENTATION: We describe an 11OHD patient presenting with precocious pseudopuberty and hypokalemia hypertension who harbored a chimeric CYP11B2/CYP11B1 with a novel breakage point located at g...
April 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29685132/acth-independent-cushing-s-syndrome-with-bilateral-cortisol-secreting-adrenal-adenomas-a-case-report-and-review-of-literatures
#8
Jia Wei, Sheyu Li, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Kaiyun Ren, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen, Jianwei Li
BACKGROUND: Adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome (CS) with bilateral cortisol-secreting adenomas has been rarely reported in the literatures. Precise recognition and management of this disorder constitute a challenge to clinicians due to the difficulty of exact location of the functional lesions. CASE PRESENTATION: We herein report a new case of a Chinese female patient with a complaint of exertional dyspnea for over 10 years. ACTH-independent CS was diagnosed based on undetectable ACTH and unsuppressed cortisol levels by dexamethasone...
April 23, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29649996/the-effects-of-synbiotic-supplementation-on-hormonal-status-biomarkers-of-inflammation-and-oxidative-stress-in-subjects-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#9
Khadijeh Nasri, Mehri Jamilian, Elham Rahmani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Zatollah Asemi
BACKGROUND: To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS. METHODS: This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria...
April 12, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29609574/utility-of-serum-igf-1-for-diagnosis-of-growth-hormone-deficiency-following-traumatic-brain-injury-and-sport-related-concussion
#10
Kirstie Lithgow, Alex Chin, Chantel T Debert, Gregory A Kline
BACKGROUND: Growth hormone deficiency (GHD) is a potential consequence of traumatic brain injury (TBI), including sport-related concussion (SRC). GH stimulation testing is required for definitive diagnosis; however, this is resource intensive and can be associated with adverse symptoms or risks. Measurement of serum IGF-1 is more practical and accessible, and pituitary tumour patients with hypopituitarism and low serum IGF-1 have been shown to have a high probability of GHD. We aimed to evaluate IGF-1 measurement for diagnosing GHD in our local TBI population...
April 2, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29587720/spontaneous-adrenocorticotropic-hormone-acth-normalisation-due-to-tumour-regression-induced-by-metyrapone-in-a-patient-with-ectopic-acth-syndrome-case-report-and-literature-review
#11
Hideyuki Iwayama, Sho Hirase, Yuka Nomura, Tatsuo Ito, Hiroyuki Morita, Kazuo Otake, Akihisa Okumura, Junko Takagi
BACKGROUND: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. CASE PRESENTATION: A 71-year-old female with general fatigue, central obesity and impaired glucose tolerance was diagnosed with Cushing's syndrome due to elevated ACTH (192...
March 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29530008/hyperglycemia-related-central-pontine-demyelinization-after-a-binge-eating-attack-in-a-patient-with-type-2-diabetes-a-case-report
#12
Rainer U Pliquett, Arno Noll, Richard Ibe, Alexandra Katz, Charlotte Ackmann, Alexandra Schreiber, Matthias Girndt
BACKGROUND: Here, we report a case of central pontine demyelinization in a type-2 diabetes patient with hyperglycemia after a binge-eating attack in the absence of a relevant hyponatremia. CASE PRESENTATION: A 55-year-old, male type-2 diabetic patient with liver cirrhosis stage Child-Pugh B was admitted due to dysmetria of his right arm, gait disturbance, dizziness, vertigo, and polyuria, polydipsia after a binge-eating attack of sweets (a whole fruit cake and 2 Liters of soft drinks)...
March 12, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29514621/a-predictive-model-of-thyroid-malignancy-using-clinical-biochemical-and-sonographic-parameters-for-patients-in-a-multi-center-setting
#13
Jia Liu, Dongmei Zheng, Qiang Li, Xulei Tang, Zuojie Luo, Zhongshang Yuan, Ling Gao, Jiajun Zhao
BACKGROUND: Thyroid nodules are highly prevalent, but a robust, feasible method for malignancy differentiation has not yet been well documented. This study aimed to establish a practical model for thyroid nodule discrimination. METHODS: Records for 2984 patients who underwent thyroidectomy were analyzed. Clinical, laboratory, and US variables were assessed retrospectively. Multivariate logistic regression analysis was performed and a mathematical model was established for malignancy prediction...
March 7, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29506520/prevalence-of-metabolic-syndrome-in-saudi-arabia-a-cross-sectional-study
#14
Khalid Al-Rubeaan, Nahla Bawazeer, Yousuf Al Farsi, Amira M Youssef, Abdulrahman A Al-Yahya, Hamid AlQumaidi, Basim M Al-Malki, Khalid A Naji, Khalid Al-Shehri, Fahd I Al Rumaih
No abstract text is available yet for this article.
March 5, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29482534/the-association-of-val109asp-polymorphic-marker-of-intelectin-1-gene-with-abdominal-obesity-in-kyrgyz-population
#15
Jainagul Isakova, Elnura Talaibekova, Denis Vinnikov, Nazira Aldasheva, Erkin Mirrakhimov, Almaz Aldashev
BACKGROUND: The aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (ITLN1) gene with the abdominal obesity (AO) in Kyrgyz population. METHODS: Patients admitted to annual screening at a local outpatient facility were enrolled or this study. We genotyped 297 nonrelated adults of Kyrgyz ethnicity, of whom 127 were AO patients, including 46 men and 81 women with the mean age 53.2 ± 7.1 years, and 170 non-obese controls, including 61 men and 109 women with the mean age 52...
February 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29482528/comparison-of-glycemic-control-and-%C3%AE-cell-function-in-new-onset-t2dm-patients-with-pcos-of-metformin-and-saxagliptin-monotherapy-or-combination-treatment
#16
Tao Tao, Peihong Wu, Yuying Wang, Wei Liu
BACKGROUND: Impaired insulin activity in women with polycystic ovary syndrome might differ from that seen in type 2 diabetes mellitus without polycystic ovary syndrome. This study was designed to compare the effects of treatment with metformin, saxagliptin, and their combination in newly diagnosed women with type 2 diabetes mellitus and polycystic ovary syndrome in China. METHODS: A total of 75 newly diagnosed patients from Shanghai, China with type 2 diabetes mellitus and polycystic ovary syndrome were included in this randomized, parallel, open-label study...
February 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29463244/a-single-center-retrospective-study-of-factors-related-to-the-effects-of-intravenous-glucocorticoid-therapy-in-moderate-to-severe-and-active-thyroid-associated-ophthalmopathy
#17
Yang Wang, Shuo Zhang, Yidan Zhang, Xingtong Liu, Hao Gu, Sisi Zhong, Yazhuo Huang, Sijie Fang, Jing Sun, Huifang Zhou, Xianqun Fan
BACKGROUND: Intravenous glucocorticoids (ivGC) have been recommended as a first-line treatment of moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, not all patients are responsive to ivGC. The identification of potential factors used to predict their efficacy and the selection of suitable patients have both been lacking. METHODS: It was a single center retrospective study. Potential factors related to the effects of ivGC were analyzed using logistic regression in 90 consecutive patients with moderate-to-severe and active TAO, who received 4...
February 20, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29458348/patients-and-caregivers-experiences-of-using-continuous-glucose-monitoring-to-support-diabetes-self-management-qualitative-study
#18
J Lawton, M Blackburn, J Allen, F Campbell, D Elleri, L Leelarathna, D Rankin, M Tauschmann, H Thabit, R Hovorka
BACKGROUND: Continuous glucose monitoring (CGM) enables users to view real-time interstitial glucose readings and provides information on the direction and rate of change of blood glucose levels. Users can also access historical data to inform treatment decisions. While the clinical and psychological benefits of CGM are well established, little is known about how individuals use CGM to inform diabetes self-management. We explored participants' experiences of using CGM in order to provide recommendations for supporting individuals to make optimal use of this technology...
February 20, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29458346/associations-between-er%C3%AE-%C3%AE-gene-polymorphisms-and-osteoporosis-susceptibility-and-bone-mineral-density-in-postmenopausal-women-a-systematic-review-and-meta-analysis
#19
Heping Zhu, Jiannong Jiang, Qiang Wang, Jun Zong, Liang Zhang, Tieliang Ma, Youjia Xu, Leiyan Zhang
BACKGROUND: Many studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. The aim of the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women. METHODS: PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library were searched...
February 20, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29433573/design-of-the-growth-hormone-deficiency-and-efficacy-of-treatment-get-score-and-non-interventional-proof-of-concept-study
#20
Peter H Kann, Simona Bergmann, Martin Bidlingmaier, Christina Dimopoulou, Birgitte T Pedersen, Günter K Stalla, Matthias M Weber, Stefanie Meckes-Ferber
BACKGROUND: The adverse effects of growth hormone (GH) deficiency (GHD) in adults (AGHD) on metabolism and health-related quality of life (HRQoL) can be improved with GH substitution. This investigation aimed to design a score summarising the features of GHD and evaluate its ability to measure the effect of GH substitution in AGHD. METHODS: The Growth hormone deficiency and Efficacy of Treatment (GET) score (0-100 points) assessed (weighting): HRQoL (40%), disease-related days off work (10%), bone mineral density (20%), waist circumference (10%), low-density lipoprotein cholesterol (10%) and body fat mass (10%)...
February 13, 2018: BMC Endocrine Disorders
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