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BMC Endocrine Disorders

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https://www.readbyqxmd.com/read/27905912/effect-of-sitagliptin-on-blood-glucose-control-in-patients-with-type-2-diabetes-mellitus-who-are-treatment-naive-or-poorly-responsive-to-existing-antidiabetic-drugs-the-jamp-study
#1
Hiroshi Sakura, Naotake Hashimoto, Kazuo Sasamoto, Hiroshi Ohashi, Sumiko Hasumi, Noriko Ujihara, Tadasu Kasahara, Osamu Tomonaga, Hideo Nunome, Masashi Honda, Yasuhiko Iwamoto
BACKGROUND: To investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were previously untreated with or who have a poor responsive to existing antidiabetic drugs. METHODS: Sitagliptin (50 mg/day) was added on to the pre-existing therapy for type 2 diabetes and changes in the glycated hemoglobin (HbA1c) level after 3 months of treatment were compared with the baseline and performed exploratory analysis...
December 1, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27903245/the-predictive-value-of-sonographic-images-of-follicular-lesions-a-comparison-with-nodules-unequivocal-in-fna-single-centre-prospective-study
#2
Dorota Słowińska-Klencka, Martyna Wojtaszek-Nowicka, Stanisław Sporny, Ewa Woźniak-Oseła, Bożena Popowicz, Mariusz Klencki
BACKGROUND: To determine the diagnostic efficacy of ultrasonographic malignancy risk features (UMRFs) in follicular lesions (FL) in a population with low risk of malignancy in FL and to compare it with a similar analysis in a group of patients with unequivocal cytology (UC): benign lesion (BL) or malignant neoplasm (MN). METHODS: Presence of UMRFs (hypoechogenicity, solid echostructure, taller-than-wide shape, pathological vascularization, irregular margins, microcalcifications and macrocalcifications) and their sets were assessed in 322 FL: 202 follicular lesions of undetermined significance (FLUS) and 120 suspicious for follicular neoplasm (SFN) and 300 nodules with UC: 200 BL and 100 MN, subsequently evaluated histopathologically...
December 1, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27894278/prevalence-and-factors-associated-with-diabetes-mellitus-and-impaired-fasting-glucose-level-among-members-of-federal-police-commission-residing-in-addis-ababa-ethiopia
#3
Tariku Tesfaye, Bilal Shikur, Tariku Shimels, Naod Firdu
BACKGROUND: The prevalence of diabetes mellitus and factors associated with it, nowadays, are increasing in alarming rates among different occupational groups. Of these occupational groups are Police officers that, often, are exposed to unique life styles and stressful situations which may lead to diabetes mellitus and other cardiovascular diseases. Due to this reason, the present study was conducted to assess the prevalence and factors associated with diabetes mellitus and impaired fasting glucose level among members of federal police commission residing in Addis Ababa, Ethiopia...
November 28, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27887605/a-randomised-open-labelstudy-of-insulin-glargine-or-neutral-protamine-hagedorn-insulin-in-chinese-paediatric-patients-with-type-1-diabetes-mellitus
#4
Min Liu, Zhiguang Zhou, Jinhua Yan, Pin Li, Wenhui Song, Junfen Fu, Xiaobo Chen, Weigang Zhao, Li Xi, Xiaoping Luo, Liang Sha, Xueyuan Deng, Chunxiu Gong
BACKGROUND: We aimed to describe the safety and efficacy of insulin glargine in Chinese paediatric patients with type 1 diabetes mellitus (T1DM). Neutral protamine Hagedorn (NPH) insulin was the reference therapy. METHODS: This open-label, randomised, Phase III study was conducted at 10 sites in China. Children aged ≥6 to <18 years with T1DM were randomised (2:1) to insulin glargine or NPH insulin asbasal insulinfor a 24-week treatment period. For all patients, insulin aspart was given as bolus insulin...
November 26, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27881164/administration-of-anti-receptor-activator-of-nuclear-factor-kappa-b-ligand-rankl-antibody-for-the-treatment-of-osteoporosis-was-associated-with-amelioration-of-hepatitis-in-a-female-patient-with-growth-hormone-deficiency-a-case-report
#5
Ayumu Takeno, Masahiro Yamamoto, Masakazu Notsu, Toshitsugu Sugimoto
BACKGROUND: Growth hormone deficiency (GHD) is associated with non-alcoholic fatty liver disease (NAFLD). A recent animal study showed that hepatocyte-specific receptor activator of nuclear factor-kappa B (RANK) knockout mice had significantly lower liver fat content compared with control mice concomitant with a decrease in production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) from hepatocytes and kupffer cells. The role of anti-RANK ligand (RANKL) antibody for osteoporosis on hepatitis in patients with aGHD is still unknown...
November 24, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27876036/diabetes-screening-intervals-based-on-risk-stratification
#6
Sachiko Ohde, Emily McFadden, Gautam A Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Rafael Perera, Zentaro Yamagata
BACKGROUND: Guidelines for frequency of Type 2 diabetes mellitus (DM) screening remain unclear, with proposed screening intervals typically based on expert opinion. This study aims to demonstrate that HbA1c screening intervals may differ substantially when considering individual risk for diabetes. METHODS: This was a multi-institutional retrospective open cohort study. Data were collected between April 1999 to March 2014 from one urban and one rural cohort in Japan...
November 22, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27876022/foot-insensitivity-is-associated-with-renal-function-decline-in-patients-with-type-2-diabetes-a-cohort-study
#7
Quratul A Altaf, Hamed Sadiqi, Milan K Piya, Abd A Tahrani
BACKGROUND: Identifying patients with diabetes at increased risk of chronic kidney disease (CKD) is essential to prevent/slow the progression to end-stage renal disease (ESRD). CKD and diabetic peripheral neuropathy (DPN) share common mechanisms. Hence, we aimed to examine the relationship between foot insensitivity and CKD in patients with Type 2 diabetes. METHODS: A prospective observational cohort study in adults with Type 2 diabetes. Patients with ESRD were excluded...
November 22, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27852255/erratum-to-adrenal-fatigue-does-not-exist-a-systematic-review
#8
Flavio A Cadegiani, Claudio E Kater
No abstract text is available yet for this article.
November 16, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27842589/the-course-of-diabetes-in-children-adolescents-and-young-adults-does-the-autoimmunity-status-matter
#9
Rasa Verkauskiene, Evalda Danyte, Rimante Dobrovolskiene, Ingrida Stankute, Diana Simoniene, Dovile Razanskaite-Virbickiene, Audrone Seibokaite, Brone Urbonaite, Nijole Jurgeviciene, Astra Vitkauskiene, Valerie Schwitzgebel, Dalia Marciulionyte
BACKGROUND: Initial classification of diabetes of young may require revision to improve diagnostic accuracy of different forms of diabetes. The aim of our study was to examine markers of beta-cell autoimmunity in a cohort of young (0-25 years) patients with type 1 diabetes and compare the presentation and course of the disease according to the presence of pancreatic antibodies. METHODS: Cross-sectional population-based study was performed covering 100% of pediatric (n = 860) and 70% of 18-25 years old adult patients (n = 349) with type 1 diabetes in Lithuania...
November 15, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27835951/obesity-and-diabetes-mellitus-association-in-rural-community-of-katana-south-kivu-in-eastern-democratic-republic-of-congo-bukavu-observ-cohort-study-results
#10
Philippe Bianga Katchunga, Justin Cikomola, Christian Tshongo, Arsene Baleke, David Kaishusha, Patrick Mirindi, Théodore Tamburhe, Yves Kluyskens, Antoine Sadiki, Socrate Bwanamudogo, Zacharie Kashongwe, Marc Twagirumukiza
BACKGROUND: Factual data exploring the relationship between obesity and diabetes mellitus prevalence from rural areas of sub-Saharan Africa remain scattered and are unreliable. To address this scarceness, this work reports population study data describing the relationship between the obesity and the diabetes mellitus in the general population of the rural area of Katana (South Kivu in the Democratic Republic of the Congo). METHODS: A cohort of three thousand, nine hundred, and sixty-two (3962) adults (>15 years old) were followed between 2012 and 2015 (or 4105 person-years during the observation period), and data were collected using the locally adjusted World Health Organization's (WHO) STEPwise approach to Surveillance (STEPS) methodology...
November 11, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27829412/gastric-bypass-surgery-reveals-independency-of-obesity-and-diabetes-melitus-type-2
#11
Mogens Fenger, Dorte Lindqvist Hansen, Dorte Worm, Lisbeth Hvolris, Viggo B Kristiansen, Elin Rebecka Carlsson, Sten Madsbad
BACKGROUND: Roux-en-Y gastric bypass surgery is widely applied to ameliorate morbid obesity, including diabetes in people with type 2 diabetes. The latter vanish a few days after surgery for many, but not in all patients before any weight reduction has occurred. The explanation for this change in metabolic status is poorly understood, but the observation may suggest that the fate obesity and diabetes is only partly linked after surgery. METHODS: The trajectories of weight reduction measured as reduced body mass index (BMI) in 741obese subjects with and without diabetes were evaluated...
November 9, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27821113/case-report-of-whole-genome-sequencing-in-the-xy-female-identification-of-a-novel-sry-mutation-and-revision-of-a-misdiagnosis-of-androgen-insensitivity-syndrome
#12
Sunita M C De Sousa, Karin S Kassahn, Liam C McIntyre, Chan-Eng Chong, Hamish S Scott, David J Torpy
BACKGROUND: The 46,XY female is characterised by a male karyotype and female phenotype arising due to any interruption in the sexual development pathways in utero. The cause is usually genetic and various genes are implicated. CASE PRESENTATION: Herein we describe a 46,XY woman who was first diagnosed with androgen insensitivity syndrome (testicular feminisation) at 18 years; however, this was later questioned due to the presence of intact Müllerian structures...
November 8, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27816062/using-hashimoto-thyroiditis-as-gold-standard-to-determine-the-upper-limit-value-of-thyroid-stimulating-hormone-in-a-chinese-cohort
#13
Yu Li, Dong-Ning Chen, Jing Cui, Zhong Xin, Guang-Ran Yang, Ming-Jia Niu, Jin-Kui Yang
BACKGROUND: Subclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TSH) levels. However, the upper limit of reference range for TSH is debated recently. This study was to determine the cutoff value for the upper normal limit of TSH in a cohort using the prevalence of Hashimoto thyroiditis as "gold" calibration standard. METHODS: The research population was medical staff of 2856 individuals who took part in health examination annually...
November 6, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27737658/the-effect-of-lifestyle-intervention-in-obesity-on-the-soluble-form-of-activated-leukocyte-cell-adhesion-molecule
#14
Alba Sulaj, Johanna Zemva, Ulrike Zech, Annika Woehning, Maik Brune, Gottfried Rudofsky, Peter P Nawroth, Thomas Fleming, Rüdiger von Bauer
BACKGROUND: The aim of this study was to investigate the effect of a lifestyle intervention in obesity on the soluble form of the activated leukocyte cell adhesion molecule (sALCAM) and its association with metabolic parameters. METHODS: Twenty-nine obese subjects selected from the OPTIFAST®52 program. This program consisted into 2 crucial phases: an initial 12-week active weight reduction phase, followed by a 40-week weight maintenance phase. At baseline, after 12 weeks and at the end of the program, fasting glucose and insulin, total cholesterol, LDL-C, HDL-C, triglycerides, adiponectin, leptin, high sensitivity CRP, sALCAM, homeostasis model assessment-estimated insulin resistance (HOMA-IR) and leptin-to-adiponectin-ratio were determined...
October 13, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27686734/single-dose-acarbose-decreased-glucose-dependent-insulinotropic-peptide-and-glucagon-levels-in-chinese-patients-with-newly-diagnosed-type-2-diabetes-mellitus-after-a-mixed-meal
#15
Zhong Chen, Xiaoying Fu, Jian Kuang, Ju Chen, Hongmei Chen, Jianhao Pei, Huazhang Yang
BACKGROUND: Acarbose slows down the intestinal absorption of carbohydrates, but its effects on the secretion of incretins are still poorly known. This study aimed to examine the effects of single-dose acarbose on the secretion of incretins in patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: In this pilot study, twenty-three patients diagnosed with T2DM were randomly assigned to the oral glucose tolerance test (OGTT) group (n = 11) and the mixed meal test (MMT) group (n = 12)...
September 29, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27680327/neonatal-and-obstetric-outcomes-in-diet-and-insulin-treated-women-with-gestational-diabetes-mellitus-a-retrospective-study
#16
Sarah H Koning, Klaas Hoogenberg, Kirsten A Scheuneman, Mick G Baas, Fleurisca J Korteweg, Krystyna M Sollie, Bertine J Schering, Aren J van Loon, Bruce H R Wolffenbuttel, Paul P van den Berg, Helen L Lutgers
BACKGROUND: To evaluate the neonatal and obstetric outcomes of pregnancies complicated by gestational diabetes mellitus (GDM). Screening and treatment - diet-only versus additional insulin therapy - were based on the 2010 national Dutch guidelines. METHODS: Retrospective study of the electronic medical files of 820 singleton GDM pregnancies treated between January 2011 and September 2014 in a university and non-university hospital. Pregnancy outcomes were compared between regular care treatment regimens -diet-only versus additional insulin therapy- and pregnancy outcomes of the Northern region of the Netherlands served as a reference population...
September 29, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27680212/arterial-stiffness-in-hypertensive-and-type-2-diabetes-patients-in-ghana-comparison-of-the-cardio-ankle-vascular-index-and-central-aortic-techniques
#17
Kwame Yeboah, Daniel A Antwi, Ben Gyan, Virginia Govoni, Charlotte E Mills, J Kennedy Cruickshank, Albert G B Amoah
BACKGROUND: Diabetes and hypertension increase arterial stiffness and cardiovascular events in all societies studied so far; sub-Saharan African studies are sparse. We investigated factors affecting arterial function in Ghanaians with diabetes, hypertension, both or neither. METHOD: Testing the hypothesis that arterial stiffness would progressively increase from controls to multiply affected patients, 270 participants were stratified into those with diabetes or hypertension only, with both, or without either...
September 29, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27680100/gender-modulated-risk-of-coronary-heart-disease-diabetes-and-coronary-mortality-among-turks-for-three-major-risk-factors-and-residual-adiposity-risk
#18
Günay Can, Altan Onat, Eray Yurtseven, Yusuf Karadeniz, Tuğba Akbaş-Şimşek, Ayşem Kaya, Hüsniye Yüksel
BACKGROUND: We determined the proportion of the effects of body mass index (BMI) or its categories on cardiometabolic outcomes mediated through systolic blood pressure (SBP), total cholesterol and fasting glucose. METHODS: Cox regression analyses were performed for incident outcomes among Turkish Adult Risk Factor study participants in whom the three mediators had been determined (n = 2158, age 48.5 ± 11 years). Over a mean 10.2-years' follow-up, new coronary heart disease (CHD) developed in 406, diabetes in 284 individuals, and 149 CHD deaths occurred...
September 29, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27629263/plantar-pressures-are-higher-in-cases-with-diabetic-foot-ulcers-compared-to-controls-despite-a-longer-stance-phase-duration
#19
Malindu E Fernando, Robert G Crowther, Peter A Lazzarini, Kunwarjit S Sangla, Scott Wearing, Petra Buttner, Jonathan Golledge
BACKGROUND: Current international guidelines advocate achieving at least a 30 % reduction in maximum plantar pressure to reduce the risk of foot ulcers in people with diabetes. However, whether plantar pressures differ in cases with foot ulcers to controls without ulcers is not clear. The aim of this study was to assess if plantar pressures were higher in patients with active plantar diabetic foot ulcers (cases) compared to patients with diabetes without a foot ulcer history (diabetes controls) and people without diabetes or a foot ulcer history (healthy controls)...
September 15, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27557747/adrenal-fatigue-does-not-exist-a-systematic-review
#20
Flavio A Cadegiani, Claudio E Kater
BACKGROUND: The term "adrenal fatigue" ("AF") has been used by some doctors, healthcare providers, and the general media to describe an alleged condition caused by chronic exposure to stressful situations. Despite this, "AF" has not been recognized by any Endocrinology society, who claim there is no hard evidence for the existence. The aim of this systematic review is to verify whether there is substantiation for "AF". METHODS: A systematic search was performed at PUBMED, MEDLINE (Ebsco) and Cochrane databases, from the beginning of the data until April 22nd, 2016...
August 24, 2016: BMC Endocrine Disorders
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