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BMC Endocrine Disorders

Xianxian Yuan, Lin Lu, Shi Chen, Jun Jiang, Xiangqing Wang, Zhihui Liu, Huijuan Zhu, Hui Pan, Zhaolin Lu
BACKGROUND: Congenital adrenal hyperplasia (CAH) resulting from steroid 11β-hydroxylase deficiency (11β-OHD) is caused by mutations in the CYP11B1 gene. It is the second major form of CAH associated with hypertension and hypopotassemia. The aim of this study was to provide a genetic analysis of 11β-OHD in a Chinese family. CASE PRESENTATION: A 19-year-old Chinese man was clinically diagnosed with 11β-OHD. His initial clinical manifestations included precocious puberty, hyperpigmentation, hypertension, and hypopotassemia...
September 21, 2018: BMC Endocrine Disorders
R S Du Puy, I Postmus, D J Stott, M R Blum, R K E Poortvliet, W P J Den Elzen, R P Peeters, B C van Munster, B H R Wolffenbuttel, R G J Westendorp, P M Kearney, I Ford, S Kean, C M Messow, T Watt, J W Jukema, O M Dekkers, J W A Smit, N Rodondi, J Gussekloo, S P Mooijaart
BACKGROUND: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base...
September 19, 2018: BMC Endocrine Disorders
Lingxia Zhao, Xuemei Fan, Lin Zuo, Qiang Guo, Xiaole Su, Guangxia Xi, Ziyan Zhang, Jianlin Zhang, Guoping Zheng
BACKGROUND: Metabolic syndrome (MetS) includes obesity, diabetes, dyslipidemia and hypertension. Its incidence is rapidly increasing worldwide, particularly in postmenopausal women. Estrogens regulate glucose homeostasis and lipid metabolism via estrogen receptors 1 (ESR1) and 2 (ESR2). The current study aimed to elucidate associations of MetS with ESR1 and ESR2 gene polymorphisms in postmenopausal Chinese women. METHODS: This case-control study included 304 postmenopausal women (154 and 150 control and MetS patients, respectively)...
September 14, 2018: BMC Endocrine Disorders
Ping Li, Shuo Lin, Ling Li, Jinhui Cui, Shuisheng Zhou, Jianhui Fan
BACKGROUND: To investigate the effect of a mildly elevated thyroid-stimulating hormone (TSH) concentration between 2.5 and 4.0 mIU/L during the first trimester on pregnancy outcomes in thyroid peroxydase antibody (TPOAb)-negative pregnant women. METHODS: A total of 1858 pregnant women who were TPOAb-negative before 13+ 6 gestational weeks, received regular prenatal services, and delivered in the third affiliated hospital of Sun Yat-Sen University were recruited from June 2016 to June 2017...
September 12, 2018: BMC Endocrine Disorders
Mohammed J Alramadan, Dianna J Magliano, Turky H Almigbal, Mohammed Ali Batais, Afsana Afroz, Hesham J Alramadhan, Waad Faozi Mahfoud, Adel Mehmas Alragas, Baki Billah
BACKGROUND: The aim of this study was to assess inadequate glycaemic control and its associated factors among people with type 2 diabetes in Saudi Arabia. METHODS: A cross-sectional study design was used. Adults with type 2 diabetes attending diabetes centres in Riyadh, Hofuf and Jeddah cities were interviewed and their anthropometrics were measured. Their medical records were also reviewed to collect information related to recent lab tests, medications, and documented comorbidities...
September 10, 2018: BMC Endocrine Disorders
Hazel Thomson, Nick Oliver, Ian F Godsland, Ara Darzi, Weerachai Srivanichakorn, Azeem Majeed, Desmond G Johnston, Arun Nanditha, Chamukuttan Snehalatha, Arun Raghavan, Priscilla Susairaj, Mary Simon, Krishnamoorthy Satheesh, Ambady Ramachandran, Stephen Sharp, Kate Westgate, Søren Brage, Nick Wareham
BACKGROUND: Type 2 diabetes is a serious clinical problem in both India and the UK. Adoption of a healthy lifestyle through dietary and physical activity modification can help prevent type 2 diabetes. However, implementing lifestyle modification programmes to high risk groups is expensive and alternative cheaper methods are needed. We are using a short messaging service (SMS) programme in our study as a tool to provide healthy lifestyle advice and an aid to motivation. The aim of the study is to assess the efficacy and user acceptability of text messaging employed in this way for people with pre-diabetes (HbA1c 6...
September 10, 2018: BMC Endocrine Disorders
Miso Jang, Hyunkyung Kim, Shorry Lea, Sohee Oh, Jong Seung Kim, Bumjo Oh
BACKGROUND: The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011. METHODS: In total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 3383 males aged ≥50 years were eligible. They underwent BMD measurement through dual-energy X-ray absorptiometry (DXA)...
September 5, 2018: BMC Endocrine Disorders
Kristian H Mikkelsen, Tina Vilsbøll, Jens J Holst, Bolette Hartmann, Filip K Knop, Morten Frost
BACKGROUND: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown...
September 4, 2018: BMC Endocrine Disorders
Andrea O Y Luk, Benny C Y Zee, Marc Chong, Risa Ozaki, Carl W Rausch, Michael H M Chan, Ronald C W Ma, Alice P S Kong, Francis C C Chow, Juliana C N Chan
BACKGROUND: Galactomannan(s) are plant-derived fiber shown to reduce post-prandial blood glucose by delaying intestinal absorption of carbohydrates and slowing down gastric emptying. We examined glucose-lowering effects of BTI320, a propriety fractionated mannan(s) administered as a chewable tablet before meal in a proof-of-concept study in Chinese subjects with prediabetes. METHODS: Sixty Chinese adults aged 18-70 years with either impaired fasting glucose, impaired glucose tolerance, or glycated haemoglobin 5...
August 31, 2018: BMC Endocrine Disorders
A Niraula, S Thapa, S Kunwar, M Lamsal, N Baral, R Maskey
BACKGROUND: Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose is underused, producing hyperglycemia. Diabetic patients are prone to opportunistic infection, thus serum ADA levels in these patients is very important as a screening test for Tuberculosis and autoimmune diseases. Thus, the present study was conducted to estimate the Serum ADA activity, glycated Haemoglobin (HbA1c), fasting and postprandial glucose level in patients with T2DM and to correlate the serum level of ADA with glycated Hemoglobin (HbA1c), fasting and postprandial glucose level in T2DM...
August 20, 2018: BMC Endocrine Disorders
E A J M Spaans, P R van Dijk, K H Groenier, P L P Brand, N Kleefstra, H J G Bilo
BACKGROUND: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children. Studies on costs related to T1DM are scarce and focused primarily on the costs directly related to diabetes. We aimed to investigate both the overall healthcare costs and the more specific costs related to the management of diabetes. METHODS: This is a retrospective and observational, nationwide cohort study of all Dutch children (aged 0-18 years) with T1DM. Data were collected from the national registry for healthcare reimbursement, in which all Dutch insurance companies combine their reimbursement data...
August 17, 2018: BMC Endocrine Disorders
Leonardo de Andrade Mesquita, Luciana Pavan Antoniolli, Giordano Fabricio Cittolin-Santos, Fernando Gerchman
BACKGROUND: The shapes of the plasma glucose concentration curve during the oral glucose tolerance test are related to different metabolic risk profiles and future risk of type 2 DM. We sought to further analyze the relationship between the specific shapes and hyperglycemic states, the metabolic syndrome and hormones involved in carbohydrate and lipid metabolism, and to isolate the effect of the shape by adjusting for the area under the glucose curve. METHODS: One hundred twenty one adult participants underwent a 2-h oral glucose tolerance test and were assigned to either the monophasic (n = 97) or the biphasic (n = 24) group based upon the rise and fall of their plasma glucose concentration...
August 16, 2018: BMC Endocrine Disorders
Francesca Sassi, Ilaria Buondonno, Chiara Luppi, Elena Spertino, Emanuela Stratta, Marco Di Stefano, Marco Ravazzoli, Gianluca Isaia, Marina Trento, Pietro Passera, Massimo Porta, Giovanni Carlo Isaia, Patrizia D'Amelio
BACKGROUND: Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors, turnover and cytokines involved in the control of bone cell formation and activity. METHODS: We enrolled in the study 21 T2DM women and 21 non diabetic controls matched for age and body mass index (BMI). In each subject we measured bone cell precursors, Receptor Activator of Nuclear Factor κB (RANKL), Osteoprotegerin (OPG), Sclerostin (SCL) and Dickoppf-1 (DKK-1) as cytokines involved in the control of osteoblast and osteoclast formation and activity, bone density (BMD) and quality trough trabecular bone score (TBS) and bone turnover...
August 8, 2018: BMC Endocrine Disorders
Leilei Liu, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Kunpeng Deng, Xu Chen, Cheng Cheng, Xinping Luo, Ming Zhang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dechen Liu, Junmei Zhou, Chengyi Han, Xuejiao Liu, Dongdong Zhang, Feiyan Liu, Chongjian Wang, Dongsheng Hu
BACKGROUND: To compare the accuracy of different obesity indexes, including waist circumference (WC), weight-to-height ratio (WHtR), body mass index (BMI), and lipid accumulation product (LAP), in predicting metabolic syndrome (MetS) and to estimate the optimal cutoffs of these indexes in a rural Chinese adult population. METHODS: This prospective cohort involved 8468 participants who were followed up for 6 years. MetS was defined by the International Diabetes Federation, American Heart Association, and National Heart, Lung, and Blood Institute criteria...
August 6, 2018: BMC Endocrine Disorders
Bilal Bin Younis, Adeela Shahid, Rozina Arshad, Saima Khurshid, Muhammad Ahmad, Haroon Yousaf
BACKGROUND: Diabetic foot ulceration is a serious limb-threatening complication of diabetes. It is the common cause of hospital admissions and amputations. The objective of the study was to determine the prevalence of diabetic foot ulcers (DFU) and its association with age, gender, duration of diabetes, peripheral neuropathy (PN), peripheral arterial disease (PAD) and HbA1c. METHODS: A total of 1940 people (≥ 30 years of age) with type 2 diabetes coming to the Sakina Institute of Diabetes and Endocrine Research (specialist diabetes clinic) at Shalamar Hospital, Lahore, Pakistan, were recruited over a period of 1 year from January 2016 to January 2017...
August 6, 2018: BMC Endocrine Disorders
Haileab Fekadu Wolde, Asrat Atsedeweyen, Addisu Jember, Tadesse Awoke, Malede Mequanent, Adino Tesfahun Tsegaye, Shitaye Alemu
BACKGROUND: Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the ninth leading cause of death related to its complications. Although the rate of vascular complications continues to rise, there is limited information about the problem. This study aimed to estimate the incidence and predictors of vascular complications among type 2 diabetes mellitus patients at University of Gondar Referral Hospital...
July 31, 2018: BMC Endocrine Disorders
Huiying Shi, Qin Zhang, Chaoqun Han, Ding Zhen, Rong Lin
BACKGROUND: The Ki-67 index in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) may change throughout the disease course. However, the definitive effect of Ki-67 variability on GEP-NENs remains unknown. The aims of this study were to evaluate changes in Ki-67 levels throughout the disease course and investigate the role of Ki-67 index variability in GEP-NENs. METHODS: Specimens with multiple pathologies were evaluated from 30 patients who were selected from 514 patients with GEP-NENs, being treated at Wuhan Union Hospital from July 2009 to February 2018...
July 28, 2018: BMC Endocrine Disorders
Zhigang Wu, Hongwei Wang, Fubiao Ni, Xuan Jiang, Ziqiang Xu, Chengyang Liu, Yong Cai, Hongxing Fu, Jiao Luo, Wenwei Chen, Bicheng Chen, Zhixian Yu
BACKGROUND: Glycaemic control is one of the most effective strategies for the treatment of diabetes-related erectile dysfunction (DMED). Compared to conventional anti-diabetic drugs and insulin, islet transplantation is more effective in the treatment of diabetic complications. The aim of this study was to investigate the efficacy of islet transplantation for reversing advanced-stage DMED in rats and to observe its influence on corpus cavernosum fibrosis. METHODS: Wistar rats were intraperitoneally injected with streptozotocin to establish a diabetes model...
July 27, 2018: BMC Endocrine Disorders
Elizabeth A Beverly, Jane Hamel-Lambert, Laura L Jensen, Sue Meeks, Anne Rubin
BACKGROUND: Diabetes in the United States has reached epidemic proportions and the people of Appalachia have been disproportionately affected by this disease. Strategies that complement standard diabetes care are critically important to mitigate the risk of complications, reduce health expenditures, and improve the quality of life of patients living in rural Appalachia. The purpose of this study was to conduct a qualitative process evaluation of a patient navigation program for diabetes after its first year of implementation...
July 27, 2018: BMC Endocrine Disorders
Mahmut Apaydin, Asli Gencay Can, Muhammed Kizilgul, Selvihan Beysel, Seyfullah Kan, Mustafa Caliskan, Taner Demirci, Ozgur Ozcelik, Mustafa Ozbek, Erman Cakal
INTRODUCTION: Vitamin D deficiency is a common health problem. Vitamin D supplements are used to improve vitamin D status; however, there are contradictory data related to what doses to give and how often they should be given. Many studies have investigated the effects of vitamin D supplementation on muscle strength, but the results remain controversial. We aimed to compare the effects and safety of single high-dose with daily low-dose oral colecalciferol on 25(OH)D levels and muscle strength in postmenopausal women with vitamin D deficiency or insufficiency...
July 21, 2018: BMC Endocrine Disorders
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