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BMC Endocrine Disorders

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https://www.readbyqxmd.com/read/29976183/papillary-thyroid-carcinoma-with-pleomorphic-tumor-giant-cells-in-a-pregnant-woman-a-case-report
#1
Johan O Paulsson, Jan Zedenius, C Christofer Juhlin
BACKGROUND: Papillary thyroid carcinoma with pleomorphic tumor giant cells (PTC-PC) is characterized by the occurrence of bizarre, pleomorphic cells within a small area of a conventional PTC. The histologic distinction between PTC-PC and PTC's with a focal anaplastic thyroid cancer (ATC) component (denoted in the 2004 WHO classification as "papillary thyroid carcinoma with spindle and giant cell carcinoma", PTC-SGC) is debated, however the prognosis is thought to be different (excellent for PTC-PC, poor for PTC-SGC)...
July 5, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29973163/factors-associated-with-type-2-diabetes-in-patients-with-vascular-dementia-a-population-based-cross-sectional-study
#2
Chun-Lin Liu, Ming-Yen Lin, Shang-Jyh Hwang, Ching-Kuan Liu, Huei-Lan Lee, Ming-Tsang Wu
BACKGROUND: Incidence of dementia is growing rapidly and affects many people worldwide. Type 2 diabetes mellitus (DM) might link cognitive decline and dementia, but the reasons for this association remain unclear. Our study explored the factors associated with type 2 DM in patients with dementia. METHODS: Patients (n = 40,404) with vascular dementia were identified in Taiwan's 1997 to 2008 National Health Insurance Research Database and divided into a DM group and non-DM group...
July 4, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29970080/screening-for-vitamin-d-deficiency-in-a-tropical-area-results-of-a-sun-exposure-questionnaire
#3
Fernanda Barros Bittar, Charlles H M Castro, Vera Lúcia Szejnfeld
BACKGROUND: Vitamin D deficiency is pandemic while resources available to measure 25-hydroxyvitamin D (25OHD) are limited. The present study aimed to verify whether sun exposure measured by a structured questionnaire could predict serum 25OHD concentrations in healthy Caucasian individuals living in a tropical area. METHODS: A cross-sectional study was carried out in subjects living in the greater São Paulo area, Brazil. Two groups of 50 young (20 to 40 years old) and 50 older (60 to 80 years old) subjects (N = 200) answered a structured questionnaire on sun exposure and had blood samples drawn for serum 25OHD concentration measurement during both summer and winter...
July 3, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29940924/community-based-study-to-assess-the-prevalence-of-diabetic-foot-syndrome-and-associated-risk-factors-among-people-with-diabetes-mellitus
#4
S P Vibha, Muralidhar M Kulkarni, A B Kirthinath Ballala, Asha Kamath, G Arun Maiya
BACKGROUND: Diabetic foot is one of the most significant and devastating complication of diabetes. The objective of this study was to assess the prevalence of diabetic foot syndrome (DFS) and the associated risk factors among people with diabetes mellitus. METHODS: A community based cross-sectional study was carried out among 620 subjects with diabetes mellitus (DM) in rural areas of Udupi district. The Michigan Neuropathy Screening Instrument was used to identify peripheral neuropathy...
June 26, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29929558/postoperative-tight-glycemic-control-significantly-reduces-postoperative-infection-rates-in-patients-undergoing-surgery-a-meta-analysis
#5
Yuan-Yuan Wang, Shuang-Fei Hu, Hui-Min Ying, Long Chen, Hui-Li Li, Fang Tian, Zhen-Feng Zhou
BACKGROUND: The benefit results of postoperative tight glycemic control (TGC) were controversial and there was a lack of well-powered studies that support current guideline recommendations. METHODS: The EMBASE, MEDLINE, and the Cochrane Library databases were searched utilizing the key words "Blood Glucose", "insulin" and "Postoperative Period" to retrieve all randomized controlled trials evaluating the benefits of postoperative TGC as compared to conventional glycemic control (CGC) in patients undergoing surgery...
June 22, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29921267/an-unusual-case-of-ectopic-corticotrophin-releasing-hormone-syndrome-caused-by-an-adrenal-noncatecholamine-secreting-pheochromocytoma-a-case-report
#6
Bao-Ping Wang, Lei-Lei Yang, Hao Wang, Qing He, Zhong-Shu Ma, Yi Lin, Chang-Xin Jiang, Hao-Ran Sun, Ming Liu
BACKGROUND: Pheochromocytoma, especially for noncatecholamine-secreting pheochromocytoma, is an extremely rare cause of ectopic corticotrophin-releasing hormone (CRH) syndrome. CASE PRESENTATION: A 27-year-old Chinese woman was administered dexamethasone for a skin allergy, but her general condition rapidly deteriorated over a month. She was subsequently hospitalized for typical clinical features of Cushing's syndrome. Endocrinological investigation confirmed severe hypercortisolism along with elevated plasma adrenocorticotropin hormone (ACTH)...
June 19, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29914457/determining-the-joint-effect-of-obesity-and-diabetes-on-functional-disability-at-3-months-and-on-all-cause-mortality-at-1-year-following-an-ischemic-stroke
#7
Colleen Bauza, Sharon D Yeatts, Keith Borg, Gayenell Magwood, Renee' H Martin, Anbesaw Selassie, Marvella E Ford
BACKGROUND: Obesity and diabetes mellitus, or diabetes, are independently associated with post-ischemic stroke outcomes (e.g., functional disability and all-cause mortality). Although obesity and diabetes are also associated with post-ischemic stroke outcomes, the joint effect of obesity and diabetes on these post-ischemic stroke outcomes has not been explored previously. The purpose of the current study was to explore whether the effect of obesity on post-ischemic stroke outcomes differed by diabetes status in a cohort of acute ischemic stroke subjects with at least a moderate stroke severity...
June 18, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29895283/il-10-stat3-is-reduced-in-childhood-obesity-with-hypertriglyceridemia-and-is-related-to-triglyceride-level-in-diet-induced-obese-rats
#8
Yuesheng Liu, Dong Xu, Chunyan Yin, Sisi Wang, Min Wang, Yanfeng Xiao
BACKGROUND: The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development of comorbidities and poor prognosis in obesity. This study aims to evaluate interleukin-10 (IL-10) in childhood obesity with hypertriglyceridemia. METHOD: We evaluated IL-10 and signal transducer and activator of transcription 3 (STAT3) mRNA expression in adipose tissue (AT) as well as serum IL-10 in 62 children of 3 groups and in high-fat diet (HFD) induced obese rat...
June 13, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29895265/reintroducing-testosterone-in-the-db-db-mouse-partially-restores-normal-glucose-metabolism-and-insulin-resistance-in-a-leptin-independent-manner
#9
Koichi Yabiku, Keiko Nakamoto, Akihiro Tokushige
BACKGROUND: Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentrations of testosterone have been found to inhibit the development of arteriosclerosis, obesity and diabetes. However, these findings have not been verified by testosterone replacement in animal models and whether or not testosterone acts directly by activating AR to enhance leptin signaling, or indirectly by its conversion into estrogen remains unclear...
June 13, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29884168/mortality-in-children-with-classic-congenital-adrenal-hyperplasia-and-21-hydroxylase-deficiency-cah-in-germany
#10
Helmuth G Dörr, Hartmut A Wollmann, Berthold P Hauffa, Joachim Woelfle
BACKGROUND: Adrenal crises in children with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) are life-threatening and have the potential to death. METHODS: A survey was performed among Paediatric Endocrinologists in Germany to report on deceased children with CAH. Our survey covered the whole of Germany. RESULTS: The participating centres reported 14 cases of death (9 female, 5 male) from 1973 until 2004, but no deaths thereafter...
June 8, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29884162/nivolumab-induced-thyroid-dysfunction-lacking-antithyroid-antibody-is-frequently-evoked-in-japanese-patients-with-malignant-melanoma
#11
Seiichi Yano, Kenji Ashida, Hiromi Nagata, Kenji Ohe, Naoko Wada, Yukina Takeichi, Yuki Hanada, Yuta Ibayashi, Lixiang Wang, Shohei Sakamoto, Ryuichi Sakamoto, Hiroshi Uchi, Motoaki Shiratsuchi, Masutaka Furue, Masatoshi Nomura, Yoshihiro Ogawa
BACKGROUND: Nivolumab, an anti-programmed cell death-1 monoclonal antibody, has improved the survival of patients with malignant melanoma. Despite its efficacy, nivolumab inconsistently induces thyroid dysfunction as an immune-related adverse event (irAE). This study aimed to evaluate nivolumab-induced thyroid dysfunction to determine the risks and mechanisms of thyroid irAEs. METHODS: After excluding 10 patients, data of 24 patients with malignant melanoma (aged 17-85 years; 54% female) were retrospectively analyzed...
June 8, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29884151/hypoglycaemia-in-diabetes-do-we-think-enough-of-the-cause-an-observational-study-on-prevalence-and-causes-of-hypoglycaemia-among-patients-with-type-2-diabetes-in-an-out-patient-setting-in-sri-lanka
#12
H A Dissanayake, G S P Keerthisena, K K K Gamage, J H Liyanage, I R H S Ihalagama, W M U A Wijetunga, T A D Tillekaratne, G W Katulanda, P Katulanda
BACKGROUND: Hypoglycaemia is a feared experience for people with diabetes. We aimed to study the prevalence and causes of hypoglycaemia among Sri Lankans with diabetes. METHODS: One thousand patients with diabetes attending a private sector diabetic clinic were interviewed using a structured questionnaire. Hypoglycaemic episodes within the preceding month were inquired and severity was graded according to clinical features and/or capillary blood glucose levels. RESULTS: Mean age 55...
June 8, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29855368/general-health-status-in-iranian-diabetic-patients-assessed-by-short-form-36-questionnaire-a-systematic-review-and-meta-analysis
#13
Masoud Behzadifar, Rahim Sohrabi, Roghayeh Mohammadibakhsh, Morteza Salemi, Sharare Taheri Moghadam, Masood Taheri Mirghaedm, Meysam Behzadifar, Hamid Reza Baradaran, Nicola Luigi Bragazzi
BACKGROUND: Diabetes mellitus is one of the most prevalent diseases worldwide. Diabetes is a chronic disease associated with micro- and macro-vascular complications and deterioration in general health status. Therefore, the aim of this study was to estimate general health status among Iranian diabetic patients through a systematic review and meta-analysis of study utilizing the Short-Form-36 questionnaire. METHODS: Searching the EMBASE, PubMed, ISI/Web of Sciences (WOS), MEDLINE via Ovid, PsycoINFO, as well as Iranian databases (MagIran, Iranmedex, and SID) from January 2000 to December 2017...
May 31, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29843706/the-product-of-fasting-plasma-glucose-and-triglycerides-improves-risk-prediction-of-type-2-diabetes-in-middle-aged-koreans
#14
Joung-Won Lee, Nam-Kyoo Lim, Hyun-Young Park
BACKGROUND: Screening for risk of type 2 diabetes mellitus (T2DM) is an important public health issue. Previous studies report that fasting plasma glucose (FPG) and triglyceride (TG)-related indices, such as lipid accumulation product (LAP) and the product of fasting glucose and triglyceride (TyG index), are associated with incident T2DM. We aimed to evaluate whether FPG or TG-related indices can improve the predictive ability of a diabetes risk model for middle-aged Koreans. METHODS: 7708 Koreans aged 40-69 years without diabetes at baseline were eligible from the Korean Genome and Epidemiology Study...
May 30, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29843700/comparison-of-health-related-quality-of-life-hrqol-among-patients-with-pre-diabetes-diabetes-and-normal-glucose-tolerance-using-the-15d-hrqol-questionnaire-in-greece-the-deplan-study
#15
Konstantinos Makrilakis, Stavros Liatis, Afroditi Tsiakou, Chryssoula Stathi, Eleftheria Papachristoforou, Despoina Perrea, Nicholas Katsilambros, Nikolaos Kontodimopoulos, Dimitrios Niakas
BACKGROUND: Diabetes mellitus is usually preceded by a pre-diabetic stage before the clinical presentation of the disease, the influence of which on persons' quality of life is not adequately elucidated. The purpose of this study was to compare the Health-Related Quality of Life (HRQOL) of persons with pre-diabetes with that of diabetes or normal glucose tolerance (NGT), using the validated HRQOL-15D questionnaire. METHODS: The HRQOL-15D scores of 172 people with pre-diabetes (108 with Impaired Fasting Glucose [IFG], 64 with Impaired Glucose Tolerance [IGT], aged 58...
May 29, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29843692/quality-improvement-strategies-at-primary-care-level-to-reduce-inequalities-in-diabetes-care-an-equity-oriented-systematic-review
#16
Natalie Terens, Simona Vecchi, Anna Maria Bargagli, Nera Agabiti, Zuzana Mitrova, Laura Amato, Marina Davoli
BACKGROUND: There is evidence that disparities exist in diabetes prevalence, access to diabetes care, diabetes-related complications, and the quality of diabetes care. A wide range of interventions has been implemented and evaluated to improve diabetes care. We aimed to review trials of quality improvement (QI) interventions aimed to reduce health inequities among people with diabetes in primary care and to explore the extent to which experimental studies addressed and reported equity issues...
May 29, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29793475/effect-of-hypothyroidism-on-the-hypothalamic-pituitary-ovarian-axis-and-reproductive-function-of-pregnant-rats
#17
Jianran Sun, Cancan Hui, Tongjia Xia, Min Xu, Datong Deng, Faming Pan, Youmin Wang
BACKGROUND: This study aimed to detect changes in hormone levels in the hypothalamic-pituitary-ovarian axis in Sprague-Dawley (SD) rats with hypothyroidism, and identify differences in the pregnancy and abortion rates of female adult rats. The potential role of gonadotropin releasing hormone (GnRH) as the link between the hypothalamic-pituitary-ovarian axis and reproductive function regulated by thyroid hormones was also investigated. METHODS: Female SD rats (n = 136) were causally classified into two groups: the normal-drinking-water group (n = 60) and the 0...
May 24, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29783969/association-between-thyroid-hormones-and-the-components-of-metabolic-syndrome
#18
Jieun Jang, Youngsook Kim, Jaeyong Shin, Sang Ah Lee, Young Choi, Eun-Cheol Park
BACKGROUND: Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify whether significant correlations exist between thyroid hormone levels and components of the metabolic syndrome in the general population of Korea. METHODS: The data were collected from the sixth Korea National Health and Nutrition Examination Surveys from 2013 to 2015...
May 21, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29764441/case-report-identification-of-an-hnf1b-p-arg527gln-mutation-in-a-maltese-patient-with-atypical-early-onset-diabetes-and-diabetic-nephropathy
#19
Nikolai Paul Pace, Johann Craus, Alex Felice, Josanne Vassallo
BACKGROUND: The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity of the disease. In this report we describe a case of atypical non autoimmune diabetes associated with a damaging HNF1β mutation. This is distinguished by a number of uncharacteristic clinical features, including early-onset obesity, the absence of renal cysts and diabetic nephropathy...
May 15, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29747617/pheochromocytoma-as-a-rare-cause-of-hypertension-in-a-46-x-i-x-q10-turner-syndrome-a-case-report-and-literature-review
#20
Ji Yeon Shin, Bo Hyun Kim, Young Keum Kim, Tae Hwa Kim, Eun Heui Kim, Min Jin Lee, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, In Joo Kim
BACKGROUND: Cardiovascular disease (CVD) presents the most serious health problems and contributes to the increased mortality in young women with Turner syndrome. Arterial hypertension in Turner syndrome patients is significantly more prevalent than that in a general age-matched control group. The aetiology of hypertension in Turner syndrome varies, even in the absence of cardiac anomalies and obvious structural renal abnormalities. Pheochromocytoma is an extremely rare cause among various etiologies for hypertension in patients with Turner syndrome...
May 10, 2018: BMC Endocrine Disorders
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