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BMC Endocrine Disorders

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https://www.readbyqxmd.com/read/29110656/in-patient-tolvaptan-use-in-siadh-care-audit-therapy-observation-and-outcome-analysis
#1
Malik Asif Humayun, Iain C Cranston
BACKGROUND: Indications for use of tolvaptan in SIADH-associated hyponatraemia remain controversial. We audited our local guidelines for Tolvaptan use in this situation to review treatment implications including drug safety, hospital admission episode analysis (episodes of liver toxicity, CNS myelinolysis, sodium-related re-admission rates), morbidity; mortality and underlying aetiologies. METHODS: We report a retrospective case series analysis of on-going treatment outcomes (case-note review) for 31 patients (age 73...
November 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29110647/a-randomized-placebo-controlled-clinical-trial-evaluating-the-safety-and-efficacy-of-the-once-weekly-dpp-4-inhibitor-omarigliptin-in-patients-with-type-2-diabetes-mellitus-inadequately-controlled-by-glimepiride-and-metformin
#2
Seung-Hwan Lee, Ira Gantz, Elizabeth Round, Melanie Latham, Edward A O'Neill, Paulette Ceesay, Shailaja Suryawanshi, Keith D Kaufman, Samuel S Engel, Eseng Lai
BACKGROUND: Type 2 diabetes (T2D) is a progressive disease that often requires a patient to use multiple antihyperglycemic agents to achieve glycemic control with disease progression. Omarigliptin is a once-weekly dipeptidyl peptidase-4 inhibitor. The purpose of this trial was to assess the efficacy and safety of adding omarigliptin to the treatment regimen of patients with T2D inadequately controlled by dual therapy with metformin and glimepiride. METHODS: Patients with T2D and HbA1c ≥7...
November 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29065865/effectiveness-and-safety-of-exenatide-in-korean-patients-with-type-2-diabetes-inadequately-controlled-with-oral-hypoglycemic-agents-an-observational-study-in-a-real-clinical-practice
#3
You-Cheol Hwang, Ari Kim, Euna Jo, Yeoree Yang, Jae-Hyoung Cho, Byung-Wan Lee
BACKGROUND: Randomized clinical trials have shown the efficacy and safety of short-acting exenatide in patients with type 2 diabetes mellitus (T2DM). The aim of this observational study was to investigate the effectiveness and safety of exenatide twice a day in Korean patients with T2DM who are suboptimally controlled with oral hypoglycemic agents. METHODS: This study was a post hoc analysis of multi-center (71 centers), prospective, observational, single-arm, post-marketing study of short-acting exenatide 5 to 10 μg twice a day from March 2008 to March 2014 and analyzed those who finished the follow-up over 20 weeks of medication...
October 25, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29065866/serum-vaspin-concentration-in-elderly-patients-with-type-2-diabetes-mellitus-and-macrovascular-complications
#4
Wei Yang, Yun Li, Tian Tian, Li Wang, Pearl Lee, Qi Hua
BACKGROUND: Adipose tissue, an endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis. Vaspin is a novel adipocyte with insulin sensitizing effects. In this study, we planned to estimate serum vaspin concentrations as related to glycemic status and the presence of macrovascular complications among elderly patients with type-2 diabetes mellitus (T2DM). METHODS: A total of 230 elderly patients with T2DM were evaluated...
October 24, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29037214/thyroid-function-and-metabolic-syndrome-in-the-population-based-lifelines-cohort-study
#5
Bruce H R Wolffenbuttel, Hanneke J C M Wouters, Sandra N Slagter, Robert P van Waateringe, Anneke C Muller Kobold, Jana V van Vliet-Ostaptchouk, Thera P Links, Melanie M van der Klauw
BACKGROUND: The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to MetS prevalence in a large population-based study...
October 16, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29037177/development-and-psychometric-testing-of-a-theory-based-tool-to-measure-self-care-in-diabetes-patients-the-self-care-of-diabetes-inventory
#6
Davide Ausili, Claudio Barbaranelli, Emanuela Rossi, Paola Rebora, Diletta Fabrizi, Chiara Coghi, Michela Luciani, Ercole Vellone, Stefania Di Mauro, Barbara Riegel
BACKGROUND: Self-care is essential for patients with diabetes mellitus. Both clinicians and researchers must be able to assess the quality of that self-care. Available tools have various limitations and none are theoretically based. The aims of this study were to develop and to test the psychometric properties of a new instrument based on the middle range-theory of self-care of chronic illness: the Self-Care of Diabetes Inventory (SCODI). METHODS: Forty SCODI items (5 point Likert type scale) were developed based on clinical recommendations and grouped into 4 dimensions: self-care maintenance, self-care monitoring, self-care management and self-care confidence based on the theory...
October 16, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29029608/association-of-trace-metal-elements-with-lipid-profiles-in-type-2-diabetes-mellitus-patients-a-cross-sectional-study
#7
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients. METHODS: The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. All the eligible study participants responded to the structured interviewer administered questionnaire and fasting venous blood was drawn for biochemical analysis...
October 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29017477/mechanism-of-worsening-diabetic-retinopathy-with-rapid-lowering-of-blood-glucose-the-synergistic-hypothesis
#8
Ahmadou M Jingi, Aurel T Tankeu, Narcisse Assene Ateba, Jean Jacques Noubiap
Insulin treatment has been associated with a paradoxical worsening of diabetes retinopathy since many years in European cohorts. Recently, this issue has been stressed by some studies conducted in other parts of the world. However, the mechanism underlying such evolution is not well understood. An osmotic theory has been evocated but failed to explain the clinical features of the disease. Considering recent findings from basic and clinical research, we discuss the possibility of a synergistic hypothesis based on the simultaneous action of insulin and vascular endothelial growth factor on eye blood vessels...
October 10, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28985731/screening-for-celiac-disease-in-poorly-controlled-type-2-diabetes-mellitus-worth-it-or-not
#9
Muhammed Kizilgul, Ozgur Ozcelik, Selvihan Beysel, Hakan Akinci, Seyfullah Kan, Bekir Ucan, Mahmut Apaydin, Erman Cakal
BACKGROUND: Recent studies have demonstrated that immune factors might have a role in the pathophysiology of insulin resistance and type 2 diabetes mellitus (T2DM). Inappropriate glycemic control in patients with T2DM is an important risk factor for the occurrence of diabetes complications. The prevalence of celiac disease (CD) is high in type 1 diabetes mellitus however, there are scarce data about its prevalence in T2DM. Our aim was to investigate the prevalence of celiac disease among insulin-using type 2 diabetes patients with inappropriate glycemic control...
October 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28974210/hypertension-outcomes-of-adrenalectomy-in-patients-with-primary-aldosteronism-a-systematic-review-and-meta-analysis
#10
Yu Zhou, Meilian Zhang, Sujie Ke, Libin Liu
BACKGROUND: The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies. METHODS: We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of PubMed, Embase, Cochrane, China National Knowledge Internet (CNKI), WanFang, SinoMed and Chongqing VIP databases were performed from initial state to May 20, 2016...
October 3, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28946907/the-relationship-between-bile-acid-concentration-glucagon-like-peptide-1-fibroblast-growth-factor-15-and-bile-acid-receptors-in-rats-during-progression-of-glucose-intolerance
#11
Xinfeng Yan, Peicheng Li, Zhaosheng Tang, Bo Feng
BACKGROUND: Recent studies show that bile acids are involved in glucose and energy homeostasis through activation of G protein coupled membrane receptor (TGR5) and farnesoid X receptor (FXR). A few researches have explored changes of TGR5 and FXR in animals with impaired glucose regulation. This study aimed to observe changes of plasma total bile acids (TBA), glucagon-like-peptide 1 (GLP-1), fibroblast growth factor 15 (FGF15), intestinal expressions of TGR5 and FXR, and correlations between them in rats with glucose intolerance...
September 25, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28923047/prepubertal-onset-of-slipped-capital-femoral-epiphysis-associated-with-hypothyroidism-a-case-report-and-literature-review
#12
Saori Kadowaki, Tomohiro Hori, Hideki Matsumoto, Kaori Kanda, Michio Ozeki, Yu Shirakami, Norio Kawamoto, Hidenori Ohnishi, Toshiyuki Fukao
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese. CASE PRESENTATION: The patient was an 8-year-old boy suffering from bilateral SCFE with hypothyroidism...
September 18, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28893233/clinical-characteristics-of-adrenal-crisis-in-adult-population-with-and-without-predisposing-chronic-adrenal-insufficiency-a-retrospective-cohort-study
#13
Masahiro Iwasaku, Maki Shinzawa, Shiro Tanaka, Kimihiko Kimachi, Koji Kawakami
BACKGROUND: Adrenal crisis (AC) occurs in various clinical conditions but previous epidemiological studies in AC are limited to chronic adrenal insufficiency (AI) and sepsis. The aim of this study was to investigate characteristics of AC patients, including predisposing diseases and to describe candidate risk factors for AC such as comorbidities and glucocorticoid (GC) therapy. METHODS: We conducted a retrospective cohort study using a claims database on 7.4 million patients from 145 acute care hospitals between January 1, 2003 and April 30, 2014...
September 11, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28888222/primary-hyperparathyroidism-caused-by-enormous-unilateral-water-clear-cell-parathyroid-hyperplasia
#14
Georgios Boutzios, Helen Sarlanis, Anna Kolindou, Antigoni Velidaki, Theodore Karatzas
BACKGROUND: Parathyroid water-clear cell hyperplasia (WCCH) and water-clear cell adenoma (WCCA) are rare causes of primary hyperparathyroidism. The frequency of WCCH seems to be less than 1% of all primary hyperplasia. CASE PRESENTATION: We report a 53-year-old woman with a large unilateral water clear cell parathyroid hyperplasia associated with primary hyperparathyroidism and severe osteoporosis. Ultrasonography showed a 5.4 cm multilobulated hypoechoic well defined mass localized in the lower half of the left thyroid lobe...
September 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28882117/awareness-and-practices-regarding-eye-diseases-among-patients-with-diabetes-a-cross-sectional-analysis-of-the-codiab-vd-cohort
#15
Lazaros Konstantinidis, Tania Carron, Eva de Ancos, Léonie Chinet, Isabelle Hagon-Traub, Emilie Zuercher, Isabelle Peytremann-Bridevaux
BACKGROUND: The increasing prevalence of diabetes is leading to a rise of eye diseases, augmenting the risk of sight-threatening complications. The aim of this study was to evaluate prevalence, awareness and practices regarding eye diseases among patients with diabetes in the canton of Vaud, Switzerland. METHODS: A cohort of 323 patients with diabetes completed a self-administered questionnaire assessing prevalence, awareness and practices regarding eye diseases, besides health status and quality of care measures...
September 7, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28874187/prolonged-preoperative-treatment-of-acromegaly-with-somatostatin-analogs-may-improve-surgical-outcome-in-patients-with-invasive-pituitary-macroadenoma-knosp-grades-1-3-a-retrospective-cohort-study-conducted-at-a-single-center
#16
Lian Duan, Huijuan Zhu, Bing Xing, Feng Gu
BACKGROUND: This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly. METHODS: An analysis of 358 patients with acromegaly was conducted. The preoperative medical therapy group (81 patients) received SSA treatment for at least 3 months prior to surgery, while the primary surgery group (277 patients) underwent transsphenoidal surgery directly. Follow-up duration was ≥3 months. Tumor invasion was evaluated by magnetic resonance imaging (MRI) and classified according to the Knosp grading system...
September 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28865461/multihormonal-pituitary-adenoma-concomitant-with-pit-1-and-tpit-lineage-cells-causing-acromegaly-associated-with-subclinical-cushing-s-disease-a-case-report
#17
Tomoko Takiguchi, Hisashi Koide, Hidekazu Nagano, Akitoshi Nakayama, Masanori Fujimoto, Ai Tamura, Eri Komai, Akina Shiga, Takashi Kono, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Yui Miyabayashi, Norio Ishiwatari, Kentaro Horiguchi, Yukio Nakatani, Koutaro Yokote, Tomoaki Tanaka
BACKGROUND: A functional pituitary adenoma can produce multiple anterior-pituitary hormones, such as growth hormone (GH) -producing adenomas (GHoma) with prolactin or thyrotropin stimulating hormone production in the same lineage. However, it is very rare that acromegaly shows subclinical Cushing's disease (SCD) beyond the lineage. Here we describe the involvement of intratumoral coexistence with 2 types of hormone-producing cells associated with different lineage in acromegaly concomitant with SCD...
September 2, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28841871/insulin-treatment-corrects-hepcidin-but-not-ykl-40-levels-in-persons-with-type-2-diabetes-mellitus-matched-by-body-mass-index-waist-to-height-ratio-c-reactive-protein-and-creatinine
#18
Driton Vela, Jovica Leshoski, Zana Vela, Muharrem Jakupaj, Mitko Mladenov, Ramadan B Sopi
BACKGROUND: It has been shown that hepcidin and YKL-40 levels change in persons with insulin resistance in different circumstances. However, variations of the levels of these parameters through the stages of prediabetes and type 2 diabetes mellitus are unclear. We hypothesized that hepcidin levels will decrease in persons with prediabetes, while these levels will tend to correct when persons with diabetes are treated with insulin. Finally we sought to determine the levels of YKL-40 in all groups of participants included in the study...
August 25, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28821302/participation-of-adults-with-disorders-differences-of-sex-development-dsd-in-the-clinical-study-dsd-life-design-methodology-recruitment-data-quality-and-study-population
#19
Robert Röhle, Katharina Gehrmann, Maria Szarras-Czapnik, Hedi Claahsen-van der Grinten, Catherine Pienkowski, Claire Bouvattier, Peggy Cohen-Kettenis, Anna Nordenström, Ute Thyen, Birgit Köhler
BACKGROUND: dsd-LIFE is a comprehensive cross-sectional clinical outcome study of individuals with disorders/differences of sex development (DSD). This study focuses on various rare genetic conditions characterized by impaired gonadal or adrenal functionality. METHODS/DESIGN: The study aims to assess quality of life (QoL) as a measure of psychosocial adaptation, psychosexual and mental health aspects as major outcomes. Health status and functioning, medical and surgical therapies, participants' views on health care, psychological and social support, sociodemographic factors and their interrelations will be investigated as factors associated with the outcomes...
August 18, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28810850/variations-in-diabetes-remission-rates-after-bariatric-surgery-in-spanish-adults-according-to-the-use-of-different-diagnostic-criteria-for-diabetes
#20
María R Alhambra-Expósito, María J Molina-Puerta, María I Prior-Sánchez, Gregorio Manzano-García, Alfonso Calañas-Continente, María A Gálvez-Moreno
BACKGROUND: There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and from the American Diabetes Association (ADA). We also aim to analyse the degree of correlation between these sets of criteria. METHODS: Retrospective observational study in 127 patients undergoing bariatric surgery in a single centre (Hospital Universitario Reina Sofía, Córdoba, Spain) between January 2001 and December 2009...
August 15, 2017: BMC Endocrine Disorders
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