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BMC Clinical Pathology

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https://www.readbyqxmd.com/read/28588422/a-rare-case-of-poorly-differentiated-thyroid-carcinoma-probably-arising-from-a-nodular-goiter
#1
Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Ken-Ichi Yoshida, Kana Anno, Masayuki Tori, Masahiko Tsujimoto
BACKGROUND: Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare. CASE PRESENTATION: A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Carcinoma cells were arranged in trabecular, solid, and microfollicular histological patterns and displayed high mitotic activity...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28465671/high-expression-of-epha3-erythropoietin-producing-hepatocellular-a3-in-gastric-cancer-is-associated-with-metastasis-and-poor-survival
#2
Baongoc Nasri, Mikito Inokuchi, Toshiaki Ishikawa, Hiroyuki Uetake, Yoko Takagi, Sho Otsuki, Kazuyuki Kojima, Tatsuyuki Kawano
BACKGROUND: As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor has been related to progression and prognosis in different types of tumors. However, the role and mechanism of EPHA3 in gastric cancer is still not well understood. METHODS: Specimen were collected from 202 patients who underwent gastric resection for gastric adenocarcinoma. The expression of EphA3 was studied using immunohistochemistry. We analyzed the clinicopathological factors and prognostic relevance of EphA3 expression in gastric cancer...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28405178/utilizing-bd-max%C3%A2-enteric-bacterial-panel-to-detect-stool-pathogens-from-rectal-swabs
#3
Barbara DeBurger, Sarah Hanna, Eleanor A Powell, Cindi Ventrola, Joel E Mortensen
BACKGROUND: The BD MAX™ Enteric Bacterial Panel (BDM-EBP) is designed and FDA-cleared to detect Salmonella, Shigella, Campylobacter, and Shiga toxin genes stx1/2 from stool samples. However, rectal swabs, which are not FDA-cleared for clinical testing with the BDM-EBP, are common specimens received from pediatric patients for enteric pathogen testing. The purpose of this study was to evaluate the ability of the BDM-EBP to detect stool pathogens from rectal swabs. METHODS: Routine cultures, Shiga toxin testing, and molecular testing with BDM-EBP were performed on 272 sequential rectal swabs collected from August 2015 to December 2015...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28405177/mapping-mitochondrial-heteroplasmy-in-a-leydig-tumor-by-laser-capture-micro-dissection-and-cycling-temperature-capillary-electrophoresis
#4
Paulo Refinetti, Christian Arstad, William G Thilly, Stephan Morgenthaler, Per Olaf Ekstrøm
BACKGROUND: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occurred in a founding cell and spread through cell division. Micro-anatomical dissection of a tumor coupled with assays for mitochondrial point mutations permits new insights into this growth process. More generally, the ability to detect and trace, at a histological level, somatic mitochondrial mutations in human tissues and tumors, makes these mutations into markers for lineage tracing...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28396615/bone-pathologic-fracture-revealing-an-unusual-association-coexistence-of-langerhans-cell-histiocytosis-with-rosai-dorfman-disease
#5
Boubacar Efared, Asmae Mazti, Badarou Chaibou, Gabrielle Atsame-Ebang, Ibrahim Sory Sidibé, Layla Tahiri, Fatimazahra Erregad, Nawal Hammas, Abdelmajid El Mrini, Hinde El Fatemi, Laila Chbani
BACKGROUND: The coexistence of Rosai-Dorfman disease (RDD) with Langerhans cell histiocytosis (LCH) is very rare, as to date only 17 cases have been reported in the english literature. The pathophysiology of this uncommon co-occurrence still remains enigmatic and a subject of various speculations. CASE PRESENTATION: We report a case of a 30-year-old female patient who presented with a pathologic fracture of the left proximal femur. Her medical history was unremarkable, there were no fever, skin lesions, lymphadenopathy or other organomegaly at physical examination...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28396614/can-takotsubo-cardiomyopathy-be-diagnosed-by-autopsy-report-of-a-presumed-case-presenting-as-cardiac-rupture
#6
Andrew Mitchell, François Marquis
BACKGROUND: Takostsubo (stress) cardiomyopathy (TC) is a clinical syndrome featuring transient left ventricular dysfunction and wall-motion abnormalities, usually following emotional or physical stress. The diagnosis of TC depends on fulfillment of multiple clinical criteria. Although the pathogenesis has not been firmly established, myocardial cathecholamine toxicity is thought to represent a primary mechanism. The vast majority of patients with TC survive. However, a rare cause of death in TC is myocardial rupture...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28396613/expression-of-human-epidermal-growth-factor-receptor-2-in-bladder-urothelial-carcinoma
#7
Mohamed Reda El Ochi, Mohamed Oukabli, Elarbi Bouaiti, Hafsa Chahdi, Adil Boudhas, Mohamed Allaoui, Ahmed Ameur, Mohamed Abbar, Abderrahmane Al Bouzidi
BACKGROUND: Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. Despite many reports in the literature, the prognostic significance of this overexpression remains unclear. The aim of this study was to assess the expression of HER2 in urothelial bladder carcinomas and its association with clinical and pathological parameters. METHODS: 103 cases of UBC were diagnosed in our department between January 2014 and December 2015...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28203117/peritumoral-lymphatic-vessel-density-and-invasion-detected-with-immunohistochemical-marker-d240-is-strongly-associated-with-distant-metastasis-in-breast-carcinoma
#8
Nur Fatiha Norhisham, Choi Yen Chong, Sabreena Safuan
BACKGROUND: Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to distinguish between blood vessel invasion and lymphatic vessel invasion. Both are important prognostic criteria however with different outcomes. The aim of this study is to distinguish between blood vessel invasion and lymphatic vessel invasion using conventional assessment and immunohistochemical markers...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28167862/mycetoma-in-a-non-endemic-area-a-diagnostic-challenge
#9
Boubacar Efared, Layla Tahiri, Marou Soumana Boubacar, Gabrielle Atsam-Ebang, Nawal Hammas, El Fatemi Hinde, Laila Chbani
BACKGROUND: Mycetoma is a chronic granulomatous infectious disease caused by filamentous bacteria or by fungi. The disease is endemic in certain tropical and subtropical areas of the world but can be found elsewhere posing sometimes a diagnostic challenge for clinicians. CASE PRESENTATION: A 65-year- old man presented with a right foot swelling evolving for 25 years. During that time, several diagnosis and treatments have been made without any improvement. The disease spread to bones, and misdiagnosed as Kaposi's sarcoma...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27708545/chromosomal-abnormality-of-acute-promyelocytic-leukemia-other-than-pml-rara-a-case-report-of-acute-promyelocytic-leukemia-with-del-5q
#10
Osamu Imataki, Makiko Uemura
BACKGROUND: The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with conventional chemotherapy. The pivotal study indicated that favorable-risk acute promyelocytic leukemia patients can be cured without any cytotoxic chemotherapy. Even high-risk patients are treatable with cytotoxic agents. Acute promyelocytic leukemia does not develop only by the dedifferentiation caused by PML-RARA...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27688734/oxidative-profile-of-sickle-cell-patients-in-a-cameroonian-urban-hospital
#11
Vicky Jocelyne Ama Moor, Constant Anatole Pieme, Bernard Chetcha Chemegne, Helene Manonji, Borgia Legrand Njinkio Nono, Corine Tchoula Mamiafo, Bruno Moukette Moukette, Francine Tankeu Nzufo, Asonganyi Tazoacha
BACKGROUND: Sickle cell disease (SCD) is a class of hemoglobinopathy resulting from a single mutation in the ß-globin chain inducing the substitution of valine for glutamic acid at the sixth amino acid position which leads to the production of abnormal haemoglobin (haemoglobin S [HbS]). Studies demonstrated the implication of oxidative stress in the development of the sickle cell disease. METHODS: The study aim was to determine the level of oxidative stress markers in a group of sickle cell homozygous patients (SS) in the Yaounde Central Hospital above 15 years of age...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27499701/dried-blood-spot-omega-3-and-omega-6-long-chain-polyunsaturated-fatty-acid-levels-in-7-9-year-old-zimbabwean-children-a-cross-sectional-study
#12
Grace Mashavave, Patience Kuona, Willard Tinago, Babill Stray-Pedersen, Marshall Munjoma, Cuthbert Musarurwa
BACKGROUND: Omega-3 long chain-polyunsaturated fatty acids (LC-PUFAs)-docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and eicosapentaenoic acid (EPA)- and omega-6 LC-PUFA arachidonic acid (ARA), are essential for optimum physical and mental development in children. Prior to this study, the blood omega-3 LC-PUFA levels were unknown in Zimbabwean children, particularly in those aged 7-9 years, despite the documented benefits of LC-PUFAs. Documentation of the LC-PUFA levels in this age group would help determine whether interventions, such as fortification, are necessary...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27478410/expression-of-podocalyxin-like-protein-is-an-independent-prognostic-biomarker-in-resected-esophageal-and-gastric-adenocarcinoma
#13
David Borg, Charlotta Hedner, Björn Nodin, Anna Larsson, Anders Johnsson, Jakob Eberhard, Karin Jirström
BACKGROUND: Podocalyxin-like protein (PODXL) is a cell surface transmembrane glycoprotein, the expression of which has been associated with poor prognosis in a range of malignancies. The aim of this study was to investigate the impact of PODXL expression on survival in esophageal and gastric adenocarcinoma. METHODS: The study cohort consists of a consecutive series of 174 patients with esophageal (including the gastroesophageal junction) or gastric adenocarcinoma, surgically treated between 2006 and 2010 and not subjected to neoadjuvant treatment...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27478409/the-study-of-calcified-atherosclerotic-arteries-an-alternative-to-evaluate-the-composition-of-a-problematic-tissue-reveals-new-insight%C3%A2-including-metakaryotic-cells
#14
Silvia Fittipaldi, Francesco Vasuri, Alessio Degiovanni, Rodolfo Pini, Mauro Gargiulo, Andrea Stella, Gianandrea Pasquinelli, William G Thilly, Elena V Gostjeva
BACKGROUND: Calcifications of atherosclerotic plaques represent a controversial issue as they either lead to the stabilization or rupture of the lesion. However, the cellular key players involved in the progression of the calcified plaques have not yet been described. The primary reason for this lacuna is that decalcification procedures impair protein and nucleic acids contained in the calcified tissue. The aim of our study was to preserve the cellular content of heavily calcified plaques with a new rapid fixation in order to simplify the study of calcifications...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27398067/histopathological-techniques-for-the-diagnosis-of-combat-related-invasive-fungal-wound-infections
#15
Sarah M Heaton, Amy C Weintrob, Kevin Downing, Bryan Keenan, Deepak Aggarwal, Faraz Shaikh, David R Tribble, Justin Wells
BACKGROUND: Effective management of trauma-related invasive fungal wound infections (IFIs) depends on early diagnosis and timely initiation of treatment. We evaluated the utility of routine staining, histochemical stains and frozen section for fungal element identification. METHODS: A total of 383 histopathological specimens collected from 66 combat-injured United States military personnel with IFIs were independently reviewed by two pathologists. Both periodic acid-Schiff (PAS) and Gomori methenamine silver (GMS) stains were used on 74 specimens...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27279799/parotid-gland-an-exceptional-localization-of-sebaceous-carcinoma-case-report
#16
Mouna Khmou, Karima Laadam, Nadia Cherradi
BACKGROUND: Sebaceous carcinoma (SC) is a rare malignancy, occurring predominantly in eyelids. Till date, only 25 cases of sebaceous carcinoma (SC) of the parotid gland have been reported in world literature. CASE PRESENTATION: A 33 year-old male presented with left sided laterocervical mass. Clinical examination showed enlargement of the left parotid gland, with cervical lymphadenopathy. No skin lesions were found. A resection of the gland was performed. Pathological findings were consistent with primary sebaceous carcinoma of the parotid gland...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27279798/5-type-hpv-mrna-versus-14-type-hpv-dna-test-test-performance-over-diagnosis-and-overtreatment-in-triage-of-women-with-minor-cervical-lesions
#17
Bjørn Westre, Anita Giske, Hilde Guttormsen, Sveinung Wergeland Sørbye, Finn Egil Skjeldestad
BACKGROUND: Repeat cytology and HPV testing is used in triage of women with minor cytological lesions. The objective of this study was to evaluate 14-type HPV DNA and 5-type HPV mRNA testing in delayed triage of women with ASC-US/LSIL. METHODS: We compared a DNA test (Roche Cobas 4800) and an 5-type mRNA test (PreTect HPV-Proofer). In total 564 women were included in the study. RESULTS: The sensitivity among solved cases for CIN3+ were 100 % (15/15) for both tests...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27274709/cellular-angiofibroma-of-the-vulva-a-poorly-known-entity-a-case-report-and-literature-review
#18
Mouna Khmou, Najat Lamalmi, Abderrahmane Malihy, Lamia Rouas, Zaitouna Alhamany
BACKGROUND: Cellular angiofibroma represents a newly described, site specific tumor. Histologically, CAF is a benign mesenchymal neoplasm characterized by two principal components: bland spindle cells and prominent small to medium-sized vessels with mural hyalinization. The indolent nature of the lesion is underscored by the uniformity of its constituent stromal cells, and their lack of nuclear atypia. Characterization by immunohistochemistry is helpful distinguishing Cellular angiofibroma from other mesenchymal lesions...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27252594/liver-cancer-with-concomitant-tp53-and-ctnnb1-mutations-a-case-report
#19
Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel, Achim Weber
BACKGROUND: In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has been suggested that both mutations occur in a mutually exclusive manner and they are used as molecular classifiers in HCC classification proposals. CASE PRESENTATION: Here, we report the case of a treatment-naïve mixed hepatocellular/cholangiocellular carcinoma (HCC/CCC) with morphological and genetic intratumor heterogeneity...
2016: BMC Clinical Pathology
https://www.readbyqxmd.com/read/27175103/primary-burkitt-lymphoma-of-the-thyroid-gland-case-report-of-an-exceptional-type-of-thyroid-neoplasm-and-review-of-the-literature
#20
Mohamed Allaoui, Ilias Benchafai, El Mehdi Mahtat, Safae Regragui, Adil Boudhas, Mustapha Azzakhmam, Mohammed Boukhechba, Abderrahmane Al Bouzidi, Mohamed Oukabli
BACKGROUND: Primary thyroid lymphoma is an uncommon pathological entity that accounts for only 1 to 5 % of all thyroid malignancies. Primary Burkitt lymphoma of the thyroid gland is very rare. This article presents the first Moroccan case of a primary BL of the thyroid to be reported in the literature to date. CASE PRESENTATION: We describe here a case of a 70-year-old male who developed a rapidly enlarging thyroid gland with progressive symptoms of compression...
2016: BMC Clinical Pathology
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