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BMC Complementary and Alternative Medicine

Ardiansyah, Yuto Inagawa, Takuya Koseki, Afifah Zahra Agista, Ikuo Ikeda, Tomoko Goto, Michio Komai, Hitoshi Shirakawa
BACKGROUND: We have previously reported that ingestion of adenosine (ADN) and adenosine-5'-monophosphate (AMP) improves abnormal glucose metabolism in the stroke-prone spontaneously hypertensive rat model of non-obesity-associated insulin resistance. In this study, we investigated the effect of ADN and AMP ingestion on glucose metabolism in mice with high-fat diet-induced obesity. METHODS: Seven-week-old C57BL/6 J mice were administered distilled water (as a control), 10 mg/L ADN, or 13 mg/L AMP via their drinking water for 14 or 25 weeks, during which they were fed a high-fat diet...
November 14, 2018: BMC Complementary and Alternative Medicine
Emmanuel Mfotie Njoya, Jacobus N Eloff, Lyndy J McGaw
BACKGROUND: Croton species (Euphorbiaceae) are distributed in different parts of the world, and are used in traditional medicine to treat various ailments including cancer, inflammation, parasitic infections and oxidative stress related diseases. The present study aimed to evaluate the antioxidant, anti-inflammatory and cytotoxic properties of different extracts from three Croton species. METHODS: Acetone, ethanol and water leaf extracts from C. gratissimus, C. pseudopulchellus, and C...
November 14, 2018: BMC Complementary and Alternative Medicine
Ni Yan, Ding-Sheng Wen, Yue-Rui Zhao, Shun-Jun Xu
BACKGROUND: Epimedium sagittatum ( Zucc.) Maxim., Ying-Yang-Huo in Chinese has been used as a traditional Chinese medicine and is deemed to "reinforce the kidney Yang". Previous studies showed that E. sagittatum could modulate the immune system and treat some chronic disease such as rheumatic arthritis, cardiovascular diseases and osteoporosis. The aim of this study is to evaluate the anti-inflammatory effects of ethyl acetate extracts (YYHs) of E. sagittatum and its mechanisms of action...
November 13, 2018: BMC Complementary and Alternative Medicine
Thiago Moreira da Silva, Carlos Danniel Pinheiro, Patricia Puccinelli Orlandi, Carlos Cleomir Pinheiro, Gemilson Soares Pontes
BACKGROUND: Essential oil obtained from rhizomes of the Zingiber zerumbet (L.) Smith (popularly known in Brazil as bitter ginger) is mainly constituted by the biomolecule zerumbone, which exhibit untapped antimicrobial potential. The aim of this study was to investigate the antimicrobial activity of the zerumbone from bitter ginger rhizomes against the cariogenic agent Streptococcus mutans. METHODS: Firstly, the essential oil from rhizomes of Zingiber zerumbet (L...
November 13, 2018: BMC Complementary and Alternative Medicine
Ze-Yu Zhang, Zhe Liu, Hui-Hui Deng, Qin Chen
BACKGROUND: Vascular dementia is the second most common type of dementia that causes cognitive dysfunction. Acupuncture, an ancient therapy, has been mentioned for the treatment of vascular dementia in previous studies. This study aimed to evaluate the effects of acupuncture in animal models of vascular dementia. METHODS: Experimental animal studies of treating vascular dementia with acupuncture were gathered from Embase, PubMed and Ovid Medline (R) from the dates of the databases' creation to December 2016...
November 13, 2018: BMC Complementary and Alternative Medicine
Monia Lenzi, Veronica Cocchi, Aleksandra Novaković, Maja Karaman, Marijana Sakač, Anamarija Mandić, Milica Pojić, Maria Cristina Barbalace, Cristina Angeloni, Patrizia Hrelia, Marco Malaguti, Silvana Hrelia
BACKGROUND: The interest towards botanicals and plant extracts has strongly risen due to their numerous biological effects and ability to counteract chronic diseases development. Among these effects, chemoprevention which represents the possibility to counteract the cancerogenetic process is one of the most studied. The extracts of mushroom Meripilus giganteus (MG) (Phylum of Basidiomycota) showed to exert antimicrobic, antioxidant and antiproliferative effects. Therefore, since its effect in leukemic cell lines has not been previously evaluated, we studied its potential chemopreventive effect in Jurkat and HL-60 cell lines...
November 12, 2018: BMC Complementary and Alternative Medicine
Amany A Thabet, Fadia S Youssef, Michal Korinek, Fang-Rong Chang, Yang-Chang Wu, Bing-Hung Chen, Mohamed El-Shazly, Abdel Nasser B Singab, Tsong-Long Hwang
BACKGROUND: Brachychiton rupestris and Brachychiton discolor (Malvaceae) are ornamental trees native to Australia. Some members of Brachychiton and its highly related genus, Sterculia, are employed in traditional medicine for itching, dermatitis and other skin diseases. However, scientific studies on these two genera are scarce. Aiming to reveal the scientific basis of the folk medicinal use of these plants, the cytotoxicity, anti-inflammatory and anti-allergic activities of Brachychiton rupestris and Brachychiton discolor leaves extracts and fractions were evaluated...
November 9, 2018: BMC Complementary and Alternative Medicine
Carolyn Ee, Caroline Smith, Michael Costello, Freya MacMillan, Lisa Moran, Brandi Baylock, Helena Teede
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a common female reproductive disorder with multiple manifestations. Weight management is a key therapeutic goal. Acupuncture is a potential adjunctive weight loss treatment in non-PCOS populations. We aimed to engage patients in co-design and assess the feasibility and acceptability of methods for a randomised controlled trial (RCT) on acupuncture and telephone-based health coaching for weight management in overweight or obese women with PCOS using qualitative methods...
November 8, 2018: BMC Complementary and Alternative Medicine
Yoshinobu Nakada, Makoto Arai
BACKGROUND: To investigate the present status of Kampo education, which has still not been elucidated, after the introduction of the new core national curriculum of 2015 into nationwide pharmacy education, in all 74 pharmacy schools in Japan. METHODS: A postal questionnaire survey was conducted from August 2015 to January 2016. The completed questionnaires were returned by mail. Web-based syllabi were also investigated to ascertain the detailed lecture curricula in each school...
November 8, 2018: BMC Complementary and Alternative Medicine
Qihong Li, Jun Wen, Kaitao Yu, Yao Shu, Wulin He, Hongxing Chu, Bin Zhang, Cheng Ge
BACKGROUND: Oral and pharyngeal cancer is the most common malignant human cancers. Chemotherapy is an effective approach for anti-oral cancer therapy, while the drug tolerance and resistance remain a problem for oral cancer patients. Aloe-emodin, rhein and physcion are classified as anthraquinones, which are the main pharmacodynamic ingredients of Rheum undulatum L.. This study was undertaken to investigate whether aloe-emodin, rhein and physcion show inhibiting growth and inducing apoptosis in oral squamous cell carcinoma SCC15 cells...
November 7, 2018: BMC Complementary and Alternative Medicine
Zhitong Bing, Zhiyuan Cheng, Danfeng Shi, Xinkui Liu, Jinhui Tian, Xiaojun Yao, Jingyun Zhang, Yongfeng Wang, Kehu Yang
BACKGROUND: Chinese traditional herbal medicine Fuzhengkangai (FZKA) formulation combination with gefitinib can overcome drug resistance and improve the prognosis of lung adenocarcinoma patients. However, the pharmacological and molecular mechanisms underlying the active ingredients, potential targets, and overcome drug resistance of the drug are still unclear. Therefore, it is necessary to explore the molecular mechanism of FZKA. METHODS: A systems pharmacology and bioinformatics-based approach was employed to investigate the molecular pathogenesis of EGFR-TKI resistance with clinically effective herb formula...
November 6, 2018: BMC Complementary and Alternative Medicine
Lin-Huang Huang, Chia-Yu Liu, Li-Yu Wang, Chien-Jung Huang, Chung-Hua Hsu
BACKGROUND: This study aims to examine the effects of green tea extract (GTE) supplement on overweight and obese women with high levels of low density lipoprotein-cholesterol (LDL-C). METHODS: The randomized, double-blind, crossover and placebo-controlled clinical trial was conducted from August 2012 to December 2013. Seventy-three out of 90 subjects aged between 18 and 65 years, with body mass index (BMI) ≥ 27 kg/m2 and LDL-C ≥ 130 mg/dl were included in the analysis...
November 6, 2018: BMC Complementary and Alternative Medicine
Chang-Soo Cho, Hye-Seong Jeong, In-Young Kim, Go-Woon Jung, Bon-Hwa Ku, Dong-Chan Park, Seung-Bae Moon, Hyung-Rae Cho, Khawaja Muhammad Imran Bashir, Sae Kwang Ku, Jae-Suk Choi
BACKGROUND: Extracellular polymeric substances isolated from Aureobasidium pullulans (EAP), containing specifically 13% β-1,3/1,6-glucan, have shown various favorable bone-preserving effects. Textoria morbifera Nakai (TM) tree has been used as an ingredient in traditional medicine and tea for various pharmacological purposes. Thus, the present study was aimed to examine the synergistic anti-osteoporotic potential of mixtures containing different proportions of EAP and TM compared with that of the single formulations of each herbal extract using bilateral ovariectomized (OVX) mice, a renowned rodent model for studying human osteoporosis...
November 6, 2018: BMC Complementary and Alternative Medicine
Guohua Yu, Wubin Wang, Xu Wang, Meng Xu, Lili Zhang, Lei Ding, Rui Guo, Yuanyuan Shi
BACKGROUND: Zuojinwan (ZJW), a classic herbal formula, has been extensively used to treat gastric symptoms in clinical practice in China for centuries. However, the pharmacological mechanisms of ZJW still remain vague to date. METHODS: In the present work, a network pharmacology-based strategy was proposed to elucidate its underlying multi-component, multi-target, and multi-pathway mode of action against gastritis. First we collected putative targets of ZJW based on TCMSP and STITCH databases, and a network containing the interactions between the putative targets of ZJW and known therapeutic targets of gastritis was built...
November 1, 2018: BMC Complementary and Alternative Medicine
Caroline A Smith, Jennifer Hunter, Geoff P Delaney, Jane M Ussher, Kate Templeman, Suzanne Grant, Eleanor Oyston
BACKGROUND: Individuals living with and beyond a cancer diagnosis are increasingly using complementary therapies and medicines (CM) to enhance the effectiveness of cancer treatment, manage treatment-related side effects, improve quality-of-life, and promote self-efficacy. In response to the increasing use and demand for CM by cancer patients, interest in the implementation of Integrative Oncology (IO) services that provide CM alongside conventional cancer care in Australia and abroad has developed...
October 29, 2018: BMC Complementary and Alternative Medicine
Eo Jin Kim, Joonghyun Ahn, Seung-Ju Kim
BACKGROUND: Spontaneous spinal epidural hematoma (SSEH) is an uncommon disease, but it can lead to acute cord compression with disabling consequences. Identifiable reasons for spontaneous hemorrhage are vascular malformations and bleeding disorders. However, SSEH after taking herbal medicines has not been described yet. CASE PRESENTATION: A 60-year-old female experienced sudden back pain combined with numbness and weakness in the lower limbs for several hours with no trauma, drug use, family history or any disease history...
October 29, 2018: BMC Complementary and Alternative Medicine
Deborah Sharp, Ava Lorenc, Gene Feder, Paul Little, Sandra Hollinghurst, Stewart Mercer, Hugh MacPherson
BACKGROUND: Comorbidity of musculoskeletal (MSK) and mental health (MH) problems is common but challenging to treat using conventional approaches. Integration of conventional with complementary approaches (CAM) might help address this challenge. Integration can aim to transform biomedicine into a new health paradigm or to selectively incorporate CAM in addition to conventional care. This study explored professionals' experiences and views of CAM for comorbid patients and the potential for integration into UK primary care...
October 29, 2018: BMC Complementary and Alternative Medicine
Masao Suzuki, Shigeo Muro, Motonari Fukui, Naoto Ishizaki, Susumu Sato, Tetsuhiro Shiota, Kazuo Endo, Tomoko Suzuki, Tadamichi Mitsuma, Michiaki Mishima, Toyohiro Hirai
BACKGROUND: There are an increasing number of evidences that chronic obstructive pulmonary disease (COPD) is a systemic illness and that bodyweight loss is its prominent manifestation. We focused on the nutritional outcomes to find out the effectiveness of acupuncture on nutritional state of COPD patients and on their prognosis in our previous interventional study. METHODS: The present study is re-analysis of our previous interventional study, COPD Acupuncture Trial (CAT) published in 2012...
October 24, 2018: BMC Complementary and Alternative Medicine
Yi Shen, Qi Zhang, Yan-Bin Wu, Yu-Qiong He, Ting Han, Jian-Hua Zhang, Liang Zhao, Hsien-Yeh Hsu, Hong-Tao Song, Bing Lin, Hai-Liang Xin, Yun-Peng Qi, Qiao-Yan Zhang
BACKGROUND: Iridoid glycosides (IGs), including monotropein (MON) and deacetyl asperulosidic acid (DA) as the main ingredients, are the major chemical components in Morinda officinalis How. (MO) root, possessing various pharmacological properties including anti-osteoporosis, anti-inflammation and anti-rheumatism activities.The aim of the present study was to further elucidate the pharmacological actions of MO by investigating the pharmacokinetics and tissue distribution of IGs in MO. METHODS: An ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS) method was developed and validated for simultaneous determination of MON and DA levels in plasma and various tissues of Wistar rats...
October 24, 2018: BMC Complementary and Alternative Medicine
Bernard Appiah, Isaac Kingsley Amponsah, Anubhuti Poudyal, Merlin Lincoln Kwao Mensah
BACKGROUND: The use of herbal medicines in developing countries has been increasing over the years. In Ghana, since 2011, the government has been piloting the integration of herbal medicine in 17 public hospitals. However, the strengths and the weaknesses of the integration have not been fully explored. The current study sought to examine the strengths and weaknesses of the integration using the WHO health systems framework. METHODS: This study used qualitative, exploratory study design involving interviews of 25 key informants...
October 22, 2018: BMC Complementary and Alternative Medicine
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