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BMC Complementary and Alternative Medicine

Isabel Cristina Celerino de Moraes Porto, Dayse Chaves Cardoso de Almeida, Gabriela Vasconcelos Calheiros de Oliveira Costa, Tayná Stéphanie Sampaio Donato, Letícia Moreira Nunes, Ticiano Gomes do Nascimento, José Marcos Dos Santos Oliveira, Carolina Batista da Silva, Natanael Barbosa Dos Santos, Maria Luísa de Alencar E Silva Leite, Irinaldo Diniz Basílio-Júnior, Camila Braga Dornelas, Pierre Barnabé Escodro, Eduardo Jorge da Silva Fonseca, Regianne Umeko Kamiya
BACKGROUND: Propolis is a natural substance produced by bees and is known to have antimicrobial activity. Our aim was to evaluate the antimicrobial effect of micellar nanocomposites loaded with an ethyl acetate extract of Brazilian red propolis as a cavity cleaning agent and its influence on the color and microtensile bond strength (μTBS) of the dentin/resin interface. METHODS: An ultra-performance liquid chromatography coupled with a diode array detector (UPLC-DAD) assay was used to determine the flavonoids and isoflavones present in an ethyl acetate extract of Brazilian red propolis (EARP) and micellar nanocomposites loaded with EARP (MNRP)...
July 18, 2018: BMC Complementary and Alternative Medicine
Seo Hyun Kim, Sung Won Lee, Hyun Jung Park, Sang Hee Lee, Won Kyun Im, Young Dong Kim, Kyung Hee Kim, Sang Jae Park, Seokmann Hong, Sung Ho Jeon
BACKGROUND: The polysaccharide component of Angelica gigas induces immuno-stimulatory effects on innate immune cells. However, it is unclear whether A. gigas' adjuvant activity on the immune system can elicit anti-cancer responses. METHODS: A water-soluble immuno-stimulatory component of A. gigas was prepared. How this ISAg modulated the activation of innate immune cells such as dendritic cells (DCs) was examined. ISAg-induced cytotoxic activity via natural killer (NK) and NKT cells was also tested using a tumor-bearing mouse model...
July 18, 2018: BMC Complementary and Alternative Medicine
Nurul Atika Razali, Nur Amiza Nazarudin, Kok Song Lai, Faridah Abas, Syahida Ahmad
BACKGROUND: Histamine is a well-known mediator involved in skin allergic responses through up-regulation of pro-inflammatory cytokines. Antihistamines remain the mainstay of allergy treatment, but they were found limited in efficacy and associated with several common side effects. Therefore, alternative therapeutic preferences are derived from natural products in an effort to provide safe yet reliable anti-inflammatory agents. Curcumin and their derivatives are among compounds of interest in natural product research due to numerous pharmacological benefits including anti-inflammatory activities...
July 16, 2018: BMC Complementary and Alternative Medicine
Jin Mo Ku, Se Hyang Hong, Soon Re Kim, Han-Seok Choi, Hyo In Kim, Dong Uk Kim, So Mi Oh, Hye Sook Seo, Tai Young Kim, Yong Cheol Shin, Chunhoo Cheon, Seong-Gyu Ko
BACKGROUND: Jawoongo is an herbal mixture used in traditional medicine to treat skin diseases. This study aimed to investigate whether Jawoongo ameliorates Atopic dermatitis (AD)-like pathology in mice and to understand its underlying cellular mechanisms. METHODS: AD was induced by 2, 4-Dinitrocholrlbenzene (DNCB) in BALB/c mice. Treatment with Jawoongo was assessed to study the effect of Jawoongo on AD in mice. Histological Analysis, blood analysis, RT-PCR, western blot analysis, ELISA assay and cell viability assay were performed to verify the inhibitory effect of Jawoongo on AD in mice...
July 13, 2018: BMC Complementary and Alternative Medicine
Hosam O Elansary, Samir A M Abdelgaleil, Eman A Mahmoud, Kowiyou Yessoufou, Khalid Elhindi, Salah El-Hendawy
BACKGROUND: Identifying ornamental plants as new natural antioxidant and antimicrobial sources is always of great importance for the ornamental and horticultural industries. METHODS: The antimicrobial activities of leaves and fruits peel essential oils of twelve ornamental and horticultural crops were determined by screening against wide spectrum of fungi and bacteria, and their respective in vitro antioxidant capacity was evaluated. Furthermore, the anticancer activities against several cancer cells, and one normal human cell line (HEK-293) were examined...
July 13, 2018: BMC Complementary and Alternative Medicine
Muhammad Majid, Bakht Nasir, Syeda Saniya Zahra, Muhammad Rashid Khan, Bushra Mirza, Ihsan-Ul Haq
BACKGROUND: Ipomoea batatas L. Lam. is a functional food and belongs to family Convolvulaceae. It is used as an antiinflammatory, aphrodisiac, antiasthmatic, anticonvalescent, antitumor, antanemic and antidiabetic agent by local communities. This study has been planned to evaluate its antiinflammatory and antiarthritic potentials. METHODS: Dry powder of I. batatas tuber and roots were extracted with ethyl acetate (IPT-EA, IPR-EA) and methanol (IPT-M, IPR-M), respectively...
July 13, 2018: BMC Complementary and Alternative Medicine
Sunanda Burman, Kuntal Bhattacharya, Devaleena Mukherjee, Goutam Chandra
BACKGROUND: Plant derived medicines show significant contributions to mankind in treating infections of pathogenic bacteria. Recently plants are used in pharmaceutical industries for novel drug preparations because to ensure efficacy and safety as synthetic antibiotics are threatened for their multidrug resistance. The present study aimed at finding antibacterial potential of aqueous and ethanolic leaf extracts of Combretum album. METHODS: Antibacterial activity was evaluated against seven bacterial strains by determining minimum inhibitory concentration (MIC) and zone of inhibition...
July 11, 2018: BMC Complementary and Alternative Medicine
Huimin Liu, Zhenfang Zhang, Huangwanyin Hu, Congen Zhang, Ming Niu, Ruishen Li, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
BACKGROUND: Liuweiwuling tablets (LWWL) are an herbal product that exerts remarkable effects on liver protection and aminotransferase levels, and they have been approved by the Chinese State Food and Drug Administration (CFDA). Clinical studies have found that LWWL can inhibit collagen production and reduce the levels of liver fibrosis markers in the serum. Thus, LWWL is expected to have beneficial effects in the treatment of liver fibrosis. The purpose of this study was to evaluate the pharmacological effects of LWWL...
July 9, 2018: BMC Complementary and Alternative Medicine
Hung-Te Hsu, Yu-Ting Tseng, Wen-Jhe Wong, Chi-Ming Liu, Yi-Ching Lo
BACKGROUND: Exposure to carbon black nanoparticles (CBNPs), a well-known industrial production, promotes pulmonary toxicity through inflammation and oxidative stress. Recent studies show that some polyphenols exert their antioxidant properties through regulation of protein kinase C-α (PKC-α) and NADPH oxidase (Nox) signaling. Resveratrol, a dietary polyphenol in fruits, possesses various health beneficial effects including anti-inflammatory and antioxidative properties. In this study, we aimed to elucidate the involvement of PKC-α and Nox in CBNPs-induced inflammation and oxidative stress, and to investigate the protective effects of resveratrol on CBNP-induced inflammation and oxidative stress in human lung epithelial A549 cells...
July 9, 2018: BMC Complementary and Alternative Medicine
Chin Theng Ng, Lai Yen Fong, Jun Jie Tan, Nor Fadilah Rajab, Faridah Abas, Khozirah Shaari, Kok Meng Chan, Fariza Juliana, Yoke Keong Yong
BACKGROUND: Clinacanthus nutans (Burm. f.) Lindau. has traditionally been using in South East Asia countries to manage cancer. However, scientific evidence is generally lacking to support this traditional claim. This study aims to investigate the in vitro, ex-vivo and in vivo effects of C. nutans extracts on angiogenesis. METHODS: C. nutans leaves was extracted with 50-100% ethanol or deionised water at 1% (w/v). Human umbilical veins endothelial cell (HUVEC) proliferation was examined using MTT assay...
July 6, 2018: BMC Complementary and Alternative Medicine
Xiaoqing Fan, Fanli Meng, Dahui Wang, Qing Guo, Zhuoyu Ji, Lei Yang, Atsushi Ogihara
BACKGROUND: In China, demands for disease prevention and health care and the prevalence of chronic non-communicable diseases have increased. TCM and general hospitals are increasingly utilizing TCM strategies for chronic non-communicable disease care and prevention. This study aimed to investigate health care professionals' (HCPs') perceptions of TCM for prevention, their TCM knowledge, and their abilities to provide such services in TCM and general hospitals. METHODS: This cross-sectional study investigated Chinese medicine hospitals and Chinese medicine departments in general hospitals in five Chinese cities...
July 6, 2018: BMC Complementary and Alternative Medicine
Raja Ram Dhungana, Mahesh Kumar Khanal, Suira Joshi, Om Prakash Kalauni, Anu Shakya, Vijay Bhrutel, Savyata Panthi, Ramesh Kumar Kc, Binod Ghimire, Achyut Raj Pandey, Bihungum Bista, Binaya Sapkota, Shiva Ram Khatiwoda, Craig Steven McLachlan, Dinesh Neupane
BACKGROUND: Hypertension control remains a major global challenge. The behavioral approaches recommended for blood pressure reduction are stress reduction, increased exercise and healthy dietary habits. Some study findings suggest that yoga has a beneficial effect in reducing blood pressure. However, the role of yoga on blood pressure has received little attention in existing health care practices in developing countries. This study will be conducted in primary health care facilities in Nepal to assess the effectiveness of a pragmatic yoga intervention to complement standard practice in further reducing blood pressure...
July 5, 2018: BMC Complementary and Alternative Medicine
Fatma Abd-Elkader Moharram, Amal Amin Al-Gendy, Siham Mostafa El-Shenawy, Bassant M Ibrahim, Mohamed A Zarka
BACKGROUND: Pimenta racemosa tree has many traditional uses where its leaves are used as herbal tea for treatment of flatulence, gastric disorder, osteoarthritis, colds and fever in addition to its analgesic and anti-inflammatory activities. So, this study aimed to isolate phenolic constituents of 80% aqueous methanol extract (AME) of leaves and evaluate its biological activities. METHODS: The defatted AME was chromatographed and structures of the isolated compounds were elucidated using UV, NMR spectroscopy and UPLC-ESI-MS analysis...
July 5, 2018: BMC Complementary and Alternative Medicine
Wei-Ming He, Jia-Qi Yin, Xu-Dong Cheng, Xun Lu, Li Ni, Yi Xi, Gui-Dong Yin, Guo-Yuan Lu, Wei Sun, Ming-Gang Wei
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) plays an important role in the progression of renal interstitial fibrosis, which finally leads to renal failure. Oleanolic acid (OA), an activator of NF-E2-related factor 2 (Nrf2), is reported to attenuate renal fibrosis in mice with unilateral ureteral obstruction. However, the role of OA in the regulation of EMT and the underlying mechanisms remain to be investigated. This study aimed to evaluate the effects of OA on EMT of renal proximal tubular epithelial cell line (NRK-52E) induced by TGF-β1, and to elucidate its underlying mechanism...
July 4, 2018: BMC Complementary and Alternative Medicine
Jungtae Leem, Wonmo Jung, Yohwan Kim, Bonghyun Kim, Kyuseok Kim
BACKGROUND: Although alopecia affects the quality of life, its pathogenesis is unknown, because cellular interactions in the hair follicle are complex. Several authors have suggested using herbal medicine to treat alopecia, and bioinformatics and network pharmacology may constitute a new research strategy in this regard because herbal medicines contain various chemical components. This study used association rule mining (ARM) and network analysis to analyze the combinations of medicinal herbs used to treat alopecia...
July 4, 2018: BMC Complementary and Alternative Medicine
Khadijeh Rabiei, Mohammad Ali Ebrahimzadeh, Majid Saeedi, Adele Bahar, Ozra Akha, Zahra Kashi
BACKGROUND: We aimed to evaluate the effects of a hydroalcoholic extract of Juglans regia L. leaves on blood glucose level and cardiovascular risk factors in type 2 diabetic patients. METHODS: In this randomized, double-blind, placebo-controlled, parallel-group (2 arms) clinical trial, 50 diabetic patients were divided into two groups: treatment group (receive the capsules containing 100 mg J. regia leaf extract) and control group (receive the capsules containing placebo, microcrystallin cellulose)...
July 4, 2018: BMC Complementary and Alternative Medicine
Vivek K Bajpai, Md Badrul Alam, Khong Trong Quan, Hee-Jeong Choi, Hongyan An, Mi-Kyoung Ju, Sang-Han Lee, Yun Suk Huh, Young-Kyu Han, MinKyun Na
BACKGROUND: Cancer is one of the most frequently occurring diseases and is the second leading cause of death worldwide. In this study, anthraquinone derivatives (Compounds 1-5) were evaluated for their anti-cancer potential against various skin and breast cancer cell lines to assess whether these anthraquinone derivatives may serve as a lead for the augmentation of anti-cancer drug. METHODS: Anthraquinone derivatives, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1 → 2)-β-glucoside (Comp 1), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone (Comp 2), and alizarin (Comp 3) were isolated from the dichloromethane fraction of the roots of Rubia philippinensis...
July 3, 2018: BMC Complementary and Alternative Medicine
Kambiz Afshar, Nina Fleischmann, Guido Schmiemann, Jutta Bleidorn, Eva Hummers-Pradier, Tim Friede, Karl Wegscheider, Michael Moore, Ildikó Gágyor
BACKGROUND: Uncomplicated urinary tract infections (UTI) are common in general practice and usually treated with antibiotics. This contributes to increasing resistance rates of uropathogenic bacteria. A previous trial showed a reduction of antibiotic use in women with UTI by initial symptomatic treatment with ibuprofen. However, this treatment strategy is not suitable for all women equally. Arctostaphylos uva-ursi (UU, bearberry extract arbutin) is a potential alternative treatment. This study aims at investigating whether an initial treatment with UU in women with UTI can reduce antibiotic use without significantly increasing the symptom burden or rate of complications...
July 3, 2018: BMC Complementary and Alternative Medicine
Sanaa K Bardaweel, Boulanouar Bakchiche, Husam A ALSalamat, Maria Rezzoug, Abdelaziz Gherib, Guido Flamini
BACKGROUND: Mentha spicata (M. spicata) is a member of Lamiaceae that spreads mainly in the temperate and sub-temperate zones of the world. It is considered as a rich source of essential oils, which is widely used in pharmaceutical industries and food production. The objectives of the current study were to evaluate chemical composition, antioxidant, antimicrobial and antiproliferative activities associated with the essential oil of M. spicata cultivated in Algerian Saharan Atlas. METHODS: The aerial parts of M...
July 3, 2018: BMC Complementary and Alternative Medicine
Refilwe G Kudumela, Lyndy J McGaw, Peter Masoko
BACKGROUND: The constant emergence of antibiotic resistant species and the adverse side effects of synthetic drugs are threatening the efficacy of the drugs that are currently in use. This study was aimed at investigating the possible antibacterial interactions, anti-inflammatory and cytotoxic effects of selected medicinal plants based on their traditional usage. METHODS: The acetone extracts of four plant species were assessed independently and in combination for antibacterial activity using microdilution assay and the sum of the fractional inhibitory concentration (FIC) was calculated...
July 3, 2018: BMC Complementary and Alternative Medicine
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