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Journal of Separation Science

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https://www.readbyqxmd.com/read/28346746/simultaneous-determination-of-4-hydroxyphenyl-lactic-acid-4-hydroxyphenyl-acetic-acid-and-3-4-hydroxyphenyl-propionic-acid-in-human-urine-by-ultra-high-performance-liquid-chromatography-with-fluorescence-detection
#1
Yongli Yang, Fan Liu, Yiqun Wan
A simple and reliable method was established for simultaneous determination of 4-hydroxyphenyl acetic acid, 4-hydroxyphenyl lactic acid, and 3-4-hydroxyphenyl propionic acid in human urine by high-performance liquid chromatography with fluorescence detection. Solid-phase extraction was used to eliminate the interferences in urine. The separation of three analytes was achieved using a C18 column and a mobile phase formed by a 95:5 v/v mixture of 50 mmol/L ammonium acetate buffer at pH 6.8 that contained 5 mmol/L tetrabutyl ammonium bromide and acetonitrile...
March 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28345817/simultaneous-determination-of-multiple-active-components-in-rat-plasma-using-ultra-fast-liquid-chromatography-with-tandem-mass-spectrometry-and-application-to-a-comparative-pharmacokinetic-study-after-oral-administration-of-suan-zao-ren-decoction-and-suan-zao
#2
Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi
Suan-Zao-Ren decoction has been used to treat insomnia for many years. In this work, a rapid and sensitive ultra-fast liquid chromatography with tandem mass spectrometry method was first developed and fully validated for the simultaneous quantification of seven main active components, spinosin, mangiferin, neomangiferin, ferulic acid, liquiritin, isoliquiritin and liquiritin apioside in rat plasma. The method was also successfully applied to compare the pharmacokinetics of these active ingredients after oral administration of Suan-Zao-Ren decoction and Suan-Zao-Ren granule...
March 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28345797/metabolomics-strategy-for-the-mapping-of-volatile-exometabolome-from-saccharomyces-spp-widely-used-in-the-food-industry-based-on-comprehensive-two-dimensional-gas-chromatography
#3
Cátia Martins, Tiago Brandão, Adelaide Almeida, Sílvia M Rocha
Saccharomyces spp. are widely used in the food and beverages industries. Their cellular excreted metabolites are important for products' general quality and can contribute to product differentiation. This exploratory study presents a metabolomics strategy for the comprehensive mapping of cellular metabolites of two yeast species, Saccharomyces cerevisiae and S. pastorianus (both collected in an industrial context) through a multidimensional chromatography platform. Solid-phase microextraction was used as a sample preparation method...
March 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28342297/high-performance-liquid-chromatographic-determination-of-multi-mycotoxin-in-cereals-and-bean-foodstuffs-using-interference-removal-solid-phase-extraction-combined-with-optimized-dispersive-liquid-liquid-microextraction
#4
Jian Zhou, Jiao-Jiao Xu, Bai-Fen Huang, Zeng-Xuan Cai, Yi-Ping Ren
A novel pre-treatment was proposed for the simultaneous determination of aflatoxins, ochratoxin A and zearalenone in foodstuffs using high-performance liquid chromatography with fluorescence detection. The analytical procedure was based on a first step using a quick, easy, cheap, effective, rugged, and safe based extraction procedure, followed by salting out and purification with a C18 solid-phase extraction column as interference removal clean-up. Subsequently, collected supernatant was subjected to dispersive liquid-liquid microextraction...
March 25, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28342292/ultra-fast-liquid-chromatography-with-tandem-mass-spectrometry-determination-of-eight-bioactive-components-of-kai-xin-san-in-rat-plasma-and-its-application-to-a-comparative-pharmacokinetic-study-in-normal-and-alzheimer-s-disease-rats
#5
Xiaotong Wang, Yue Zhang, Huibin Niu, Yajing Geng, Bing Wang, Xiaomei Yang, Pengyu Yan, Qing Li, Kaishun Bi
A method of ultra-fast liquid chromatography with tandem mass spectrometry was developed and validated for the simultaneous quantitation of eight bioactive components, including polygalaxanthone III, sibiricaxanthone B, tenuifolin, sibiricose A5, sibiricose A6, tenuifoliside A, ginsenoside Re and ginsenoside Rb1 in rat plasma after oral administration of Kai-Xin-San. The plasma samples were extracted by liquid-liquid extraction using digoxin as internal standard. Chromatographic separation was performed on a Venusil MP C18 column (100 mm × 2...
March 25, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28332768/separation-of-caffeoylquinic-acids-and-flavonoids-from-asteris-souliei-by-high-performance-counter-current-chromatography-and-their-anti-inflammatory-activity-in-vitro
#6
Qiang Zhang, He-Ying Pei, Kai Chen, Huan Tang, Bo Wu, Ming-Hai Tang, Ai-Hua Peng, Hao-Yu Ye, Li-Juan Chen
Eleven compounds were successfully separated from Asteris souliei by using a two-step high-performance counter-current chromatography method. The first step involved a reversed phase isocratic counter-current chromatography separation using hexane/ethyl acetate/methanol/water (1:0.8:1:1 v/v), which produced three fractions, the first two of which were mixtures. The second step used step-gradient reversed-phase counter-current chromatography with hexane/butanol/ethyl acetate/methanol/water (1:0.5:3.5:1:4 v/v) initially followed by hexane/ethyl acetate/methanol/water (1:2:1:2 v/v) to separate Fraction 1 into seven compounds; and hexane/ethyl acetate/methanol/water (1:1:1:1...
March 23, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28323381/dendrimer-reinforced-sol-gel-based-hollow-fiber-solid-phase-microextraction-for-citalopram-determination-using-response-surface-methodology
#7
Salameh Azimi, Zarrin Es'haghi, Ghasem Rezanejade Bardajee
The inclusion of a polyamidoamine dendrimer in a silica sol-gel yielded a solid nanosorbent that was used for the preconcentration, extraction and determination of citalopram in hospital waste water, hemodialysis solution and some drinking water. The method was developed by applying a novel nanosorbent for the solid-phase microextraction of citalopram, containing a silica sol-gel reinforced by polyamidoamine second-generation dendrimer, which was protected by a polypropylene hollow fiber. Plackett-Burman design and central composite design were utilized to evaluate the significance of several factors on the extraction efficiency...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28322518/determination-of-fatty-acid-methyl-esters-derived-from-algae-scenedesmus-dimorphus-biomass-by-gc-ms-with-one-step-esterification-of-free-fatty-acids-and-transesterification-of-glycerolipids
#8
Satya Girish Chandra Avula, Joanne Belovich, Yan Xu
Algae can synthesize, accumulate and store large amounts of lipids in its cells, which holds immense potential as a renewable source of biodiesel. In this work, we have developed and validated a GC-MS method for quantitation of fatty acids and glycerolipids in forms of fatty acid methyl esters derived from algae biomass. Algae Scenedesmus dimorphus dry mass was pulverized by mortar and pestle, then, extracted by the modified Folch method and fractionated into free fatty acids and glycerolipids on aminopropyl solid-phase extraction cartridges...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28322504/rapid-characterization-of-the-major-chemical-constituents-from-polygoni-multiflori-caulis-by-liquid-chromatography-tandem-mass-spectrometry-and-comparative-analysis-with-polygoni-multiflori-radix
#9
Gui-Yang Wang, Jing Shang, Yun Wu, Gang Ding, Wei Xiao
Polygoni Multiflori Caulis is a traditional Chinese medicine that has been used for a long time to treat sleep disorders. However, the multiple chemical composition analysis has not been reported. In this study, a simple, rapid and effective ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established to characterize the components of Polygoni Multiflori Caulis. In addition, a chemical comparative analysis was performed with Polygoni Multiflori Radix, another traditional Chinese medicine from the same plant, through multivariate statistical analysis and semi-quantitative analysis to screen the difference in chemical ingredients between these two herbal medicines from same medicinal plant...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28322500/liquid-chromatography-with-mass-spectrometry-analysis-of-mycotoxins-in-food-samples-using-silica-hydride-based-stationary-phases
#10
Joseph P Pesek, Maria T Matyska, Jessica F Hoffmann, Nathalia A Madruga, Rosane L Crizel, Moacir C Elias, Nathan L Vanier, Fabio C Chaves
Liquid chromatography with mass spectrometry analysis of selected food samples using silica hydride stationary phases allowed for the identification and quantification of common mycotoxins including aflatoxin B1, B2, G1, G2, ochratoxin A, and fumosinin B1. Phenyl and C18 columns showed relatively similar selectivity based on hydrophobicity but the phenyl phase provides and additional mechanism, π-π interaction. The most hydrophobic of the analyzed compounds was more strongly retained on the C18 column and also has fewer unsaturated sites, which limited the interaction with the phenyl phase...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28322496/comparison-of-hydrodynamically-closed-two-dimensional-capillary-electrophoresis-coupled-with-ultraviolet-detection-and-hydrodynamically-open-capillary-electrophoresis-hyphenated-with-mass-spectrometry-in-the-bioanalysis-of-varenicline
#11
Juraj Piešťanský, Katarína Maráková, Jaroslav Galba, Andrej Kováč, Peter Mikuš
Two capillary electrophoresis methods for monitoring renally excreted varenicline, a highly effective drug prescribed for smoking cessation, in human urine were developed and compared. A method combining capillary electrophoresis with mass spectrometry was proposed for the fast analysis of varenicline (analysis time up to 7 min). Here, mass spectrometry was a prerequisite for achieving high sensitivity and selectivity of the analysis suitable for the quantification of a 15 ng.mL(-1) level of varenicline in un-pretreated urine matrices...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28322031/consensus-based-comparison-of-chromatographic-and-computationally-estimated-lipophilicity-of-benzothiepino-3-2-c-pyridine-derivatives-as-potential-antifungal-drugs
#12
Sandra Šegan, Nina Božinović, Igor Opsenica, Filip Andrić
Lipophilicity is one of the essential properties influencing drug absorption, excretion and metabolism. It is used for screening of viable drug candidates. Chromatographic behavior of thiepino[3,2-c:6,7-c']dipyridine and 16 benzothiepino[3,2-c]pyridine derivatives as potential antifungal drugs was studied using thin-layer chromatography under typical reversed-phase conditions and two microemulsion chromatographic systems. Seventeen chromatographic and nine in silico lipophilicity measures were estimated. They were compared by classical multivariate approaches: principal component analysis, hierarchical cluster analysis, and ranked and grouped by the non-parametric method-Sum of ranking differences...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28322019/method-for-improving-accuracy-in-full-evaporation-headspace-analysis
#13
Wei-Qi Xie, Xin-Sheng Chai
We report a new headspace analytical method in which multiple headspace extraction is incorporated with the full evaporation technique. The pressure uncertainty caused by the solid content change in the samples has a great impact to the measurement accuracy in the conventional full evaporation headspace analysis. The results (using ethanol solution as the model sample) showed that the present technique is effective to minimize such a problem. The proposed full evaporation multiple headspace extraction analysis technique is also automated and practical, and which could greatly broaden the applications of the full-evaporation-based headspace analysis...
March 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28319649/optimization-of-extraction-of-linarin-from-flos-chrysanthemi-indici-by-response-surface-methodology-and-artificial-neural-network
#14
Hongye Pan, Qing Zhang, Keke Cui, Guoquan Chen, Xuesong Liu, Longhu Wang
The extraction of linarin from Flos chrysanthemi indici by ethanol was investigated. Two modeling techniques, response surface methodology and artificial neural network, were adopted to optimize the process parameters, such as, ethanol concentration, extraction period, extraction frequency, and solvent to material ratio. We showed that both methods provided good predictions, but artificial neural network provided a better and more accurate result. The optimum process parameters include, ethanol concentration of 74%, extraction period of 2 h, extraction three times, solvent to material ratio of 12 mL/g...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28318104/integrated-evaluation-of-hplc-and-uv-fingerprints-for-the-quality-control-of-danshen-tablet-by-systematic-quantified-fingerprint-method-combined-with-antioxidant-activity
#15
Min Shi, Guoxiang Sun
Danshen tablet, which consists of Salviae Miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Borneolum syntheticum, has been widely used in the therapy of cardiovascular disease. The aim of this study was to develop comprehensive evaluation methods for the quality control of Danshen tablet. First, five-wavelength fusion fingerprint was established to avoid one-sidedness of a single wavelength. Then, the ultraviolet spectrum fingerprint was applied to reflect the information of unsaturated bond and conjugated system of chemical substances in Danshen tablet...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28317332/high-throughput-gas-chromatography-for-volatile-compounds-analysis-by-fast-temperature-programming-and-adsorption-chromatography
#16
Ronda Gras, Yujuan Hua, Jim Luong
The synergy of combining fast temperature programming capability and adsorption chromatography using fused silica based porous layer open tubular columns to achieve high throughput chromatography for the separation of volatile compounds is presented.A gas chromatograph with built-in fast temperature programming capability and having a fast cool down rate was used as a platform. When these performance features were combined with the high degree of selectivity and strong retention characteristic of porous layer open tubular column technology, volatile compounds such as light hydrocarbons of up to C7 , primary alcohols, and mercaptans can be well separated and analyzed in a matter of minutes...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28317265/simultaneous-determination-of-eight-alkaloids-and-oleandrin-in-herbal-cosmetics-by-dispersive-solid-phase-extraction-coupled-with-ultra-high-performance-liquid-chromatography-and-tandem-mass-spectrometry
#17
Zhiqing Xun, Donghong Liu, Rongrong Huang, Shuang He, Du Hu, Xindong Guo, Yanping Xian
We utilized ultra high performance liquid chromatography with tandem mass spectrometry and dispersive solid-phase extraction to develop a new method for the detection of nine analytes (scopolamine, cephaeline, strychnine, hyoscyamine, brucine, hydrastine, ajmalicine, colchicine and oleandrin) in herbal cosmetics. Acetonitrile/water and 2-propylaminoethylamine were used to disperse and purify during the dispersive solid-phase extraction step. The analytes were separated by a Waters UPLC HSS T3 column and detected through electrospray ionization source in the positive mode with multi-reaction monitoring conditions...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28317258/centrifugeless-ultrasound-assisted-emulsification-microextraction-based-on-salting-out-phenomenon-followed-by-high-performance-liquid-chromatography-for-the-simple-determination-of-phthalate-esters-in-aqueous-samples
#18
Ehsan Mirparizi, Maryam Rajabi, Mohammad Bazregar, Alireza Asghari
A fast, sensitive, and centrifugeless ultrasound-assisted emulsification microextraction followed by high performance liquid chromatography method is developed for the determination of some phthalate esters in aqueous samples. In this method, a simple approach is followed for elimination of the centrifugation step in dispersive liquid-liquid microextraction using an organic solvent whose melting point is near the ambient temperature, consumption of the extracting solvent is efficiently reduced, and the overall extraction time was found to be only 7 min...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28317248/influence-of-different-processing-times-on-the-quality-of-polygoni-multiflora-radix-by-metabolomics-based-on-ultra-high-performance-liquid-chromatography-with-quadrupole-time-of-flight-mass-spectrometry
#19
Xie-An Yu, Ai-Hua Ge, Lu Zhang, Jin Li, Mingrui An, Jun Cao, Jun He, Xiu-Mei Gao, Yan-Xu Chang
A metabolomics method based on ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry was developed to evaluate the influence of processing times on the quality of raw and processed Polygoni Multiflora Radix. Principal component analysis and partial least squares discriminant analysis was used to screen the potential maker metabolites that were contributed to the quality changes. Then these marker metabolites were selected as variables in Fisher's discriminant analysis to establish the models that were used to distinguish the raw and processed Polygoni Multiflora Radix in the markets...
March 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28306207/development-and-validation-of-a-uhplc-ms-ms-method-for-the-simultaneous-determination-of-five-bioactive-flavonoids-in-rat-plasma-and-comparative-pharmacokinetic-study-after-oral-administration-of-xiaochaihu-tang-and-three-compatibilities
#20
Yunhai Bo, Lijuan Wang, Xiao Wu, Longshan Zhao, Jingyu Yang, Zhili Xiong, Chunfu Wu
An accurate, rapid and reliable ultra high performance liquid chromatography with tandem mass spectrometry method was developed and validated for the simultaneous determination of baicalin, wogonoside, baicalein, wogonin and oroxylinA in rat plasma. Then, the stability of baicalin and baicalein in the preparation of plasma sample was systematically investigated. The Waters BEH C18 column was used with a gradient mobile phase system of acetonitrile and water containing 0.1% formic acid. The analytes were detected in the multiple reaction monitoring mode with positive electrospray ionization...
March 17, 2017: Journal of Separation Science
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