Journal of Nanoparticle Research : An Interdisciplinary Forum for Nanoscale Science and Technology

Metal and metal oxide nanoparticles (NPs) have been increasingly utilized in many industries to harness their documented antibacterial properties. However, the mechanism(s) of action is still debated in the literature. The aim of this study is to understand how changes in outer membrane charge of a test bacteria Haemophilus influenzae alter the antibacterial activity of ZnO NPs of average sizes of 20 nM and 60 nM. H. influenzae outer membrane charge was altered through use of the wild strain (Rd) and mutant lines H543 and H446...

The nanocomposites of reduced graphene oxide (RGO) and polyoxometalates (POMs) have been considered to be effective to boost more Li+ to participate in intercalation/deintercalation process of lithium-ion batteries (LIBs). In this paper, a nanocomposite (PMo12 @RGO-AIL) with electrostatic interaction of RGO and Keggin-type [PMo12 O40 ]3- has been fabricated and characterized by XRD, XPS, SEM, and TEM. To prepare PMo12 @RGO-AIL, a strategy of covalent modification is developed between amino-based ionic liquid and RGO, helping to achieve the uniform dispersion of [PMo12 O40 ]3- ...

Silver nanoparticles have a great potential in a broad range of applications such as drug-delivery carriers because of their antiviral and antibacterial properties. In this study, the coating properties of silver nanoparticle (size range of 1.6 nm) with three common anti-malarial drugs, Artemisinin, Artemether, and Artesunate have been studied by using the quantum mechanical and classical atomistic molecular dynamics simulation in order to use as the drug delivery to treat malaria and COVID-19 diseases. The optimized structure, frequencies, charge distribution, and the electrostatic potential maps of the three drug molecules were simulated by using the density functional theory (DFT) at the B3LYP/6-311++g(d,p) level of theory...

Knowledge, technology, and society as well as natural systems are increasingly coherent and complex, and new systems are continuously formed at their interfaces. Convergence is a problem-solving strategy to holistically understand, create, and transform a system for reaching a common goal, such as advancing an emerging technology in society. The systems may be either in natural, scientific, technological, economic, or societal settings. Convergence offers a unifying strategy applicable to all systems that can be modeled as evolving neural-like networks...

Coronavirus pandemic is burdening healthcare systems around the world to the full capacity they can accommodate. There is an overwhelming need to find a treatment for this virus as early as possible. Computer algorithms and deep learning can participate positively by finding a potential treatment for SARS-CoV-2. In this paper, a deep learning model and machine learning methods for the classification of potential coronavirus treatments on a single human cell will be presented. The dataset selected in this work is a subset of the publicly online datasets available on RxRx...

The current pandemic COVID-19, caused by the SARS-CoV-2 virus, has been affecting thousands of people worldwide, promoting high numbers of deaths. With this, the world population is going through a process of changing habits, with social distance, improvement of hygiene techniques, to reduce the spread of the SARS-CoV-2 virus and, consequently, reduce the number of hospitalized people in serious condition, as well as the mortality rate. This scenario has been promoting a continuous search for researchers, in the most varied areas, for possible methods of prevention or cure...

Nanoparticles may be used in vaccinology as an antigen delivery and/or an immunostimulant to enhance immunity. Porous silica has been identified as an effective adjuvant for more than a decade, and we have therefore investigated the take up rate by an immortalized macrophage-like cell line of a number of mesoporous silica nanoparticles (MSNPs) with differing diameter and pore size. The MSNPs were synthesized using a sol-gel reaction and post-synthesis removal of the template. The MSNPs showed a clear distribution in take up rate peaking at 217 nm, whereas a comparison with solid spherical nanoparticles showed a similar distribution peaking at 377 nm...

The utilization of silver nanoparticles (AgNPs) in consumer products has significantly increased in recent years, primarily due to their antimicrobial properties. Increased use of AgNPs has raised ecological concerns. Once released into an aquatic environment, AgNPs may undergo oxidative dissolution leading to the generation of toxic Ag+ . Therefore, it is critical to investigate the ecotoxicological potential of AgNPs and determine the physicochemical parameters that control their dissolution in aquatic environments...

Cationic polyethyleneimine (PEI)-conjugated gold nanoparticles (AuNPs) that are chemically and physically stable under physiological conditions are an ideal candidate for certain bio-medical applications, in particular DNA transfection. However, the issue remains in reproducibly generating uniform stable species, which can cause the inadequate characterization of the resulting product under relevant conditions and timepoints. The principal objective of the present study was to develop an optimized and reproducible synthetic route for preparing stable PEI-conjugated AuNPs (Au-PEIs)...

The functionalization of fine primary particles by atomic layer deposition (particle ALD) provides for nearly perfect nanothick films to be deposited conformally on both external and internal particle surfaces, including nanoparticle surfaces. Film thickness is easily controlled from several angstroms to nanometers by the number of self-limiting surface reactions that are carried out sequentially. Films can be continuous or semi-continuous. This review starts with a short early history of particle ALD. The discussion includes agitated reactor processing, both atomic and molecular layer deposition (MLD), coating of both inorganic and polymer particles, nanoparticles, and nanotubes...

Scheelite-type Ca1- x Mn x MoO4 ( x  = 0.0, 0.01, 0.05, 0.10 and 0.15) nanomaterials were successfully synthesized via a combustion route. Dielectric studies showed a weak n -type electrical conductivity characteristic for insulators and low relative permittivity ( ε r  < 15) decreasing with increasing Mn2+ content. CaMoO4 and Mn2+ -doped nanomaterials are chemically compatible with Al and Ag electrodes and promising for low-temperature co-fired ceramic applications. Magnetic studies showed, at room-temperature diamagnetism for pure CaMoO4 , the balance between diamagnetism and paramagnetism for Ca1- x Mn x MoO4 ( x  = 0...

This study investigated airborne particle release from seventeen nanotechnology-enabled clothing items, including eleven items that were advertised as containing silver nanoparticles. Clothing wear was simulated using an abrader, where the rotating clothing samples came in contact with felt abrader wheels, and size distribution and concentration of the released particles were measured using a Scanning Mobility Particle Sizer and Aerodynamic Particle Sizer. Through the use of inductively coupled plasma mass spectrometry, silver was detected in all eleven products advertised as containing silver, and its concentration varied from approximately 1 ppm to ~1...

Metabolites are essential for the normal operation of cells and fulfill various physiological functions. It was recently found that in several metabolic disorders, the associated metabolites could self-assemble to generate amyloid-like structures, similar to canonical protein amyloids that have a role in neurodegenerative disorders. Yet, assemblies with typical amyloid characteristics are also known to have physiological function. In addition, many non-natural proteins and peptides presenting amyloidal properties have been used for the fabrication of functional nanomaterials...

The aggregation and long-term (25 d) sedimentation behaviors of reduced graphene oxide (RGO) and its three successively self-assembled nanohybrids with magnetite (Fe3 O4 ) and zerovalent silver (Ag0 ) nanoparticles have been investigated. The aggregation behaviors of the nanomaterials in NaCl and CaCl2 were found to be in good agreement with the Derjaguin-Landau-Verwey-Overbeek (DLVO)-type interactions and the Schulze-Hardy rule. The colloidal stability decreased with the increasing ratios of the edge-based functional groups (COO- and C=O) to the total oxygen-containing functional groups decorated on the basal planes (C-O) and edges of RGO, as quantified by X-ray photoelectron spectroscopy analysis...

Evaluating the surface and core compositions of transforming nanoparticles (NP) represents a significant measurement challenge but is necessary for predicting performance in applied systems and their toxicity in natural environments. Here, we use X-ray photoelectron spectroscopy (XPS) and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to characterize both the surface and core ofpolyvinyl pyrollidone-silver nanoparticles in the presence of two Suwannee River fulvic acid (FA) standards and humic acid (HA) during sulfidation, the predominant transformation pathway in environmental systems...

Researchers in the field of environmental safety and health of nanomaterials (nanosafety) were surveyed between September 2017 and January 2018 to obtain a snapshot on the state of investigations in this field. The data received from 84 respondents give information on exposure pathways, methods, biologic and toxic effects, dose metrics and range, criteria for selecting benchmark materials, and on problems that are considered urgent in the field. The results can help guide research strategies and funding schemes related to nanosafety of nanoparticles...

Measurement of light scattered from suspensions of monodisperse nanoparticles in solution ("turbidity") long has been used to derive their size. Following some means of fractionation, the light (monochromatic) scattered by the particles into a set of distinct angles is collected and a non-linear least squares fit was made to an appropriate theory in order to extract their size. For a wide range of particle structures, where this process becomes very complex and of questionable validity, there is a far simpler interpretive means based upon measurements at extremely small, and often inaccessible, scattering angles...

Although number of stimuli-responsive drug delivery systems based on mesoporous silica nanoparticles (MSNs) have been developed, the simultaneous real-time monitoring of carrier in order to guarantee proper drug targeting still remains as a challenge. GQDs-MSNs nanocomposite nanoparticles composed of graphene quantum dots (GQDs) and MSNs are proposed as efficient doxorubicin delivery and fluorescent imaging agent, allowing to monitor intracellular localization of a carrier and drug diffusion route from the carrier...

Hydrophilic and homogeneous sub-10 nm blue light-emitting gold nanoparticles (NPs) functionalized with different capping agents have been prepared by simple chemical routes. Structure, average, size, and surface characteristics of these NPs have been widely studied, and the stability of colloidal NP solutions at different pH values has been evaluated. Au NPs show blue PL emission, particularly in the GSH capped NPs, in which the thiol-metal core transference transitions considerably enhance the fluorescent emission...

Early diagnosis is primarily important for the therapeutic and prognostic outcomes of malignancies including prostate cancer (PCa). However, the visuality and veracity of ultrasound imaging for the diagnosis and prognostic prediction of PCa remains poor at present. In this study, we developed a new nanoultrasound contrast agent by modifying multi-walled carbon nanotubes (MWCNTs) with polyethylene glycol (PEG) and anti-PSMA aptamer. The result showed that the modified MWCNTs offered better visuality and veracity and were able to target PCa cells more effectively as compared with the traditional contrast agent...