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Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]

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https://www.readbyqxmd.com/read/30004168/one-step-construction-of-the-shape-persistent-chiral-but-symmetrical-polyimine-macrocycles
#1
REVIEW
Marcin Kwit, Jakub Grajewski, Paweł Skowronek, Mikołaj Zgorzelak, Jacek Gawroński
A unique combination of structural flexibility, shape persistency and functionality, makes macrocycles and molecular cages as essential molecular entities that have displayed applications that go beyond chemistry. Among macrocycles, the selectively obtained symmetrical (poly)cyclic polyimines have shown great utility in the design of molecules varied in shape and properties. The reversible and thermodynamically controlled cycloimination reaction is governed by configurational and conformational constraints imposed on the intermediate products, ensures a sufficiently high level of preorganization...
July 13, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29993177/advances-in-selective-carbon-heteroatom-coupling-reactions
#2
REVIEW
Qingle Zeng, Li Zhang, Yue Zhou
Most of compounds containing more than one reactive groups may produce several byproducts during the coupling process. Selective carbon-heteroatom coupling reactions, which have merits of high synthetic efficiency and step economy, are the best choice to resolve the problem. Although they have made great progress, they deserve further exploration. This review discusses their recent advances and intend to inspire the research in the future. It is organized on the basis of selective carbon-heteroatom coupling reaction types, including selective C-N and C-N, C-N and C-O, C-O and C-O, C-C and C-N coupling reactions...
July 11, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29969189/rapid-optimization-of-reaction-conditions-based-on-comprehensive-reaction-analysis-using-a-continuous-flow-microwave-reactor
#3
REVIEW
Péter Vámosi, Keiya Matsuo, Tsuguya Masuda, Kohei Sato, Tetsuo Narumi, Kazuhiro Takeda, Nobuyuki Mase
Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a "9+4+1 method" to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time...
July 3, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29962078/nucleophile-initiated-catalytic-and-multicomponent-reactions
#4
REVIEW
Vijay Nair, Rajeev S Menon
A number of well-known reactions, proceed through the intermediacy of dipolar/zwitterionic species generated via the addition of a neutral nucleophile with an unsaturated electrophile. A mechanistic understanding of these reactions was made possible by seminal contributions of Huisgen. The design of novel reactions based on such dipolar species was, however, not pursued in detail for a long time. Our efforts to exploit various reactivity profiles available for the zwitterionic/dipolar intermediates have resulted in the discovery of a large number of novel, convenient protocols to access a wide variety of products...
July 2, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29962057/materials-with-nanoscale-porosity-energy-and-environmental-applications
#5
REVIEW
Piyali Bhanja, Asim Bhaumik
In this personal account, several key inventions on designing novel microporous and mesoporous materials, and their applications in energy and environmental research are reviewed. Although, crystalline materials with sub-nanometer pore size regime like zeolites, AlPOs, MOFs, ZIFs etc. are known over the years, silicious and non-silicious mesoporous materials have revolutionized the research on the materials with nanoscale porosity in last two and half decades. A wide range of inorganic, organic-inorganic hybrid as well as purely organic mesoporous materials with either periodic or disordered mesopores are known...
July 2, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29943894/recent-advances-and-developments-of-in-vitro-evaluation-of-heterocyclic-moieties-on-cancer-cell-lines
#6
REVIEW
Runjhun Tandon, Iqubal Singh, Vijay Luxami, Nitin Tandon, Kamaldeep Paul
Besides worthy development in cancer therapy, cancer is still one of the leading causes of death, worldwide. The future burden of cancer will probably be even larger because people are adopting poor lifestyles with poor diet, frequently smoking and less physical activity. The effective anticancer drugs having efficacy and selectivity with low toxicity is still a challenge for the scientific fraternity. The advances in the cancer study have its origin on the availability of different types of experimental model systems that review the various forms of this disease...
June 26, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29931800/opening-the-selectivity-pocket-in-the-human-lysine-deacetylase-sirtuin2-new-opportunities-new-questions
#7
REVIEW
Dina Robaa, Daria Monaldi, Nathalie Wössner, Norio, Kudo, Tobias Rumpf, Matthias Schiedel, Minoru Yoshida, Manfred Jung
Reversible lysine deacetylation is exerted by both zinc and NAD+ -dependent deacetylases. It is an important factor in epigenetic regulation and more generally in the posttranslational regulation of protein stability, association and activity. Some of these enzymes can also cleave off fatty acids or dicarboxylic acids from lysines in proteins. The NAD+ -dependent deacetylases are termed Sirtuins and are implicated in the pathogenesis of different diseases. For the isotype Sirt2 highly selective inhibitors have been identified in the last few years...
June 21, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29931736/synthesis-of-3-4-fused-tricyclic-indoles-using-3-alkylidene-indolines-as-versatile-precursors
#8
Tetsuhiro Nemoto
In this personal account, our recent studies of novel synthetic methods of 3,4-fused tricyclic indole derivatives using 3-alkylidene indoline derivatives as versatile precursors are discussed. Two types of cascade reactions producing 3,4-fused tricyclic 3-alkylidene indolines were developed based on a palladium-catalyzed intramolecular Heck insertion to an allene-allylic amination cascade and a platinum-catalyzed intramolecular Friedel-Crafts type C-H coupling-allylic amination cascade. Furthermore, three types of 3,4-fused tricyclic indoles were accessible from a single 3-alkylidene indoline precursor via acid-promoted olefin isomerization or oxidative treatments...
June 21, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29924464/special-issue-recent-advances-on-nanostructured-functional-materials
#9
EDITORIAL
Pilar Aranda, Clément Sanchez, Katsuhiko Ariga
No abstract text is available yet for this article.
June 20, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29920924/electrochemically-induced-michael-addition-reaction-an-overview
#10
REVIEW
Lida Fotouhi, Majid M Heravi, Vahideh Zadsirjan, Paria Asadi Atoi
Due to its high potential for the formation of carbon-carbon bonds, Michael addition reaction is one of the closest reactions to the heart of synthetic organic chemists. Electrochemistry presents a very stimulating and divergent resource for selective oxidation and reduction in organic chemistry, generating activated species, for example radical anions or radical cations. In this review, we try to underscore usefulness of electrogenerated Michael addition reaction with the hope of encouraging synthetic organic chemists to contemplate it, as an efficient and green strategy when it is required in their designed multi-step reaction pathways...
June 19, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29920922/design-and-synthesis-of-polycycles-heterocycles-and-macrocycles-via-strategic-utilization-of-ring-closing-metathesis
#11
REVIEW
Sambasivarao Kotha, Milind Meshram, Yuvaraj Dommaraju
In this perspective, we summarize new synthetic approaches for the construction of various polycyclic compounds involving ring-closing metathesis as a key step. In this regard, we used ring-closing metathesis in combination with other popular reactions like Suzuki-Miyaura coupling, Claisen rearrangement, Fischer indolization, Grignard addition, Diels-Alder reaction, and [2+2] cycloaddition reaction etc. To this end, a variety of functional molecules such as α-amino acids, cyclophanes, heterocycles, propellanes, spirocycles, and macrocycles have been prepared...
June 19, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29905399/my-twenty-years-in-microwave-chemistry-from-kitchen-ovens-to-microwaves-that-aren-t-microwaves
#12
REVIEW
C Oliver Kappe
This Personal Account describes the author's involvement in the field of microwave-assisted organic synthesis (MAOS) from the late 1990's starting out with kitchen microwave ovens right through to the development of a reactor in 2016 that - although not using microwave technology - in many ways mimics the performance of a modern laboratory microwave. The reader is taken along a journey that has spanned two decades of intense research on various aspects of microwave chemistry, and, at the same time, was intimately linked to key innovations regarding equipment design and development...
June 15, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29893461/chemical-protein-degradation-approach-and-its-application-to-epigenetic-targets
#13
REVIEW
Yukihiro Itoh
In addition to traditional drugs, such as enzyme inhibitors, receptor agonists/antagonists, and protein-protein interaction inhibitors as well as genetic technology, such as RNA interference and the CRISPR/Cas9 system, protein knockdown approaches using proteolysis-targeting chimeras (PROTACs) have attracted much attention. PROTACs, which induce selective degradation of their target protein via the ubiquitin-proteasome system, are useful for the down-regulation of various proteins, including disease-related proteins and epigenetic proteins...
June 12, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29888856/microfluidics-based-magnetophoresis-a-review
#14
REVIEW
Fadi Alnaimat, Sawsan Dagher, Bobby Mathew, Ali Hilal-Alnqbi, Saud Khashan
Magnetophoresis, the manipulation of trajectory of micro-scale entities using magnetic forces, as employed in microfluidic devices is reviewed at length in this article. Magnetophoresis has recently garnered significant interest due to its simplicity, in terms of implementation, as well as cost-effectiveness while being efficient and biocompatible. Theory associated with magnetophoresis is illustrated in this review along with different sources for creating magnetic field gradient commonly employed in microfluidic devices...
June 11, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29888443/small-molecule-based-non-fullerene-acceptors-a-comparative-study
#15
REVIEW
Yuvraj Patil, Rajneesh Misra
Organic solar cells (OSCs) have gained attention of the scientific community from the last decade and are now considered as one of the most important source for low-cost power production. The recent rapid progress in non-fullerene acceptors in BHJ indicates that they have potential to compete with fullerene-based BHJ OSCs. The present review addressed the systematic comparison among various acceptors (diketopyrrolopyrrole (DPP), benzothiadiazole (BTD) and perylenediimide (PDI) based acceptors) in order to design and improve the performance of small molecules based non-fullerene acceptors...
June 10, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29878456/mechanistic-insight-on-the-activity-and-substrate-selectivity-of-nonheme-iron-dioxygenases
#16
REVIEW
Sam P de Visser
Nonheme iron dioxygenases catalyze vital reactions for human health particularly related to aging processes. They are involved in the biosynthesis of amino acids, but also the biodegradation of toxic compounds. Typically they react with their substrate(s) through oxygen atom transfer, although often with the assistance of a co-substrate like α-ketoglutarate that is converted to succinate and CO2 . Many reaction processes catalyzed by the nonheme iron dioxygenases are stereoselective or regiospecific and hence understanding the mechanism and protein involvement in the selectivity is important for the design of biotechnological applications of these enzymes...
June 7, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29863815/catalysts-based-on-earth-abundant-metals-for-visible-light-driven-water-oxidation-reaction
#17
REVIEW
Junqi Lin, Qing Han, Yong Ding
Exploration of water oxidation catalyst (WOC) with excellent performance is the key for the overall water splitting reaction, which is a feasible strategy to convert solar energy to chemical energy. Although some compounds composed of noble metals, mainly Ru and Ir, have been reported to catalyze water oxidation with high efficiency, catalysts based on low-cost and earth-abundant transition metals are essential for realizing economical and large-scale light-driven water splitting. Various WOCs containing earth-abundant metals (mainly Mn, Fe, Co, Ni, Cu) have been utilized for visible light-driven water oxidation in recent years...
June 4, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29863802/live-cell-imaging-of-dna-methylation-based-on-synthetic-molecule-protein-hybrid-probe
#18
REVIEW
Naresh Kumar, Yuichiro Hori, Kazuya Kikuchi
The epigenetic modification of DNA involves the conversion of cytosine to 5-methylcytosine, also known as DNA methylation. DNA methylation is important in modulating gene expression and thus, regulating genome and cellular functions. Recent studies have shown that aberrations in DNA methylation are associated with various epigenetic disorders or diseases including cancer. This stimulates great interest in the development of methods that can detect and visualize DNA methylation. For instance, fluorescent proteins (FPs) in conjugation with methyl-CpG-binding domain (MBD) have been employed for live-cell imaging of DNA methylation...
June 4, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29863757/platinum-in-chemistry-an-adventure-from-phosphorescent-materials-to-catalytic-c-h-functionalization
#19
REVIEW
Shouquan Huo
Platinum is a precious and versatile metal and has played important roles in various fields of chemistry ranging from functional materials to anticancer drugs and catalysis. This account highlights an adventurous journey of platinum from promoting phosphorescence to catalyzing a C-H functionalization reaction, or you may consider it our research adventure from phosphorescent materials to catalysis. Interestingly, this journey is driven by a series of "bad" reactions, and of course more importantly by our curiosity about the "bad" reactions...
June 4, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29855139/%C3%AE-cyclodextrin-a-green-and-efficient-supramolecular-catalyst-for-organic-transformations
#20
REVIEW
Dipak S Dalal, Dipak R Patil, Yogesh A Tayade
β-Cyclodextrin is cyclic oligosaccharide possessing hydrophobic cavity, which binds the substrates selectively and catalyze number of organic transformations with high selectivity. It catalyzes the reaction by non-covalent supramolecular bonding with reversible formation of host-guest complexes as seen in enzymes. This account summarizes our efforts in designing a good number of important organic transformations using β-cyclodextrin and its derivatives. These reactions were performed in neat, aqueous as well as organic media...
June 1, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
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