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Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]

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https://www.readbyqxmd.com/read/28318093/synthesis-of-imidazo-1-2-a-pyridines-c-h-functionalization-in-the-direction-of-c-s-bond-formation
#1
REVIEW
Chitrakar Ravi, Subbarayappa Adimurthy
Imidazo[1,2-a]pyridines play an important role in medicinal chemistry. In spite of very drastic developments on syntheses and functionalization in this area, the use of inexpensive catalysts and mild reaction conditions constitutes an important role in pharmaceutical applications. This account describes our recent efforts on the development of new methods for the synthesis of imidazo[1,2-a]pyridines using readily available starting substrates and catalysts under very mild reaction conditions. In the direction of enhancement of biological activity, we also described the synthesis of functionalized imidazo [1,2-a]pyridine derivatives...
March 20, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28272766/recent-developments-in-total-syntheses-of-cephalosporolides-penisporolides-and-ascospiroketals
#2
REVIEW
Hongliang Yao, Jian Wang, Rongbiao Tong
The possible biogenetic connection of the 10-membered lactone (decanolide) and the tricyclic [5,5]-spiroacetal-cis-fused-γ-lactone (SAFL) natural products was proposed by Hanson in 1985. Mimicking such biosynthetic hypothesis led us to develop a general synthetic strategy for the total syntheses of both decanolide-type cephalosporolides and SAFL-type natural products. This biomimetic strategy features two key transformations: i) oxidative ring expansion of bicyclic β-hydroxy tetrahydropyrans to the decanolides and ii) ring contraction rearrangement of the decanolides to the tricyclic SAFLs...
March 8, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28266174/synthesis-of-functionalized-pyrazoles-via-1-3-dipolar-cycloaddition-of-%C3%AE-diazo-%C3%AE-ketophosphonates-sufones-and-esters-with-electron-deficient-alkenes
#3
REVIEW
T V Baiju, Irishi N N Namboothiri
1,3-Dipolar cycloaddition of diazo compounds with olefinic substrates is a promising atom-economic strategy for the construction of functionalized pyrazoles. Over the last few years, our group has been engaged in the synthesis of phosphonyl/sulfonylpyrazoles and pyrazole esters by employing Bestmann-Ohira Reagent (BOR) and its sulfur and ester analogs as 1,3-dipole precursors with various dipolarophiles. This account describes the novel synthetic methods developed in our laboratory, in the perspective of closely related work by others, for the synthesis of phosphonyl/sulfonylpyrazoles, pyrazole esters and the total synthesis of Withasomnine, a natural product, by using 1,3-dipolar cycloaddition as the key step...
March 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28266131/squaramide-catalyzed-asymmetric-reactions
#4
REVIEW
Bo-Liang Zhao, Jun-Hua Li, Da-Ming Du
Bifunctional squaramides have emerged as powerful hydrogen-bonding catalysts for promoting a wide array of useful asymmetric reactions, which provides convenient methods for the construction of complex molecular structures and chiral biologically active compounds. This review highlights the recent advances of our research group in the chiral squaramide-catalyzed asymmetric reactions, including Michael addition, Mannich reaction, aza-Henry reaction, Strecker reaction as well as cascade or sequential reactions...
March 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28257168/thioether-derived-macrocycle-for-peptide-secondary-structure-fixation
#5
REVIEW
Yuan Tian, Dan Yang, Xiyang Ye, Zigang Li
Recently, we developed methods to stabilize peptides into various secondary structures, including α-helix, type III turn and β-hairpin via proper thioether based macrocyclization. These conformationally constrained peptidomimetics confer enhanced biophysical properties and provide a valuable avenue towards clinically-relevant therapeutic molecules. In this personal account, thioether-derived macrocyclization methods developed by our group for stabilization of α-helix, type-III β turn and β-hairpin conformations are discussed...
March 3, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28245339/towards-more-efficient-greener-syntheses-through-flow-chemistry
#6
REVIEW
Justin A M Lummiss, Peter D Morse, Rachel L Beingessner, Timothy F Jamison
Technological advances have an important role in the design of greener synthetic processes. In this Personal Account, we describe a wide range of thermal, photochemical, catalytic, and biphasic chemical transformations examined by our group. Each of these demonstrate how the merits of a continuous flow synthesis platform can align with some of the goals put forth by the Twelve Principles of Green Chemistry. In particular, we illustrate the potential for improved reaction efficiency in terms of atom economy, product yield and reaction rates, the ability to design synthetic process with chemical and solvent waste reduction in mind as well as highlight the benefits of the real-time monitoring capabilities in flow for highly controlled synthetic output...
February 28, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28195390/self-assembly%C3%A2-of%C3%A2-renewable%C3%A2-nano-sized-triterpenoids
#7
REVIEW
Braja Gopal Bag, Rakhi Majumdar
Studies on plant metabolites have gained renewed interest in recent years because these can serve as renewable chemicals for the development of a sustainable society.Among various plant secondary metabolites, terpenoids constitute the major component and triterpenoids are the 30C subset of it.In recent years, triterpenoids have drawn the attention of scientific community due to many of its potential and realized applications in medicine, drug delivery, thermochromic materials, pollutant capture, catalysis, liquid crystals, etc...
February 14, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28169484/organocatalytic-hydrophosphonylation-reaction-of-carbonyl-groups
#8
REVIEW
Raquel P Herrera
This revision is covering the limited examples reported for a pivotal strategy in the formation of C-P bonds such as the asymmetric organocatalytic hydrophosphonylation of carbonyl groups (Pudovik reaction). The scope and limitations, and the proposed mechanisms for the scarce different possibilities of asymmetric induction are also shown. The recent evolution and future trends of this undeveloped approach are commented.
February 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28146343/catalytic-reaction-assisted-by-plasma-or-electric-field
#9
REVIEW
Shuhei Ogo, Yasushi Sekine
Direct conversion of methane, other hydrocarbons, and alcohol at lower temperatures can be achieved using plasma or an electric field and catalysts. Non-equilibrium plasma enables activation of stable molecules including methane, carbon dioxide, and water, even at low temperatures, by virtue of high electron energy. Use of a hybrid system of plasma and catalyst provided high conversion and selectivity to products by virtue of adsorption on the catalyst. Imposing a DC electric field to the catalyst bed also promotes catalytic reactions, even at low temperatures...
February 1, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28105702/hydrodynamic-effects-in-soft-matter-self-assembly-the-case-of-j-aggregates-of-amphiphilic-porphyrins
#10
REVIEW
Josep M Ribo, Zoubir El-Hachemi, Oriol Arteaga, Adolf Canillas, Joaquim Crusats
Chiral J-aggregates of achiral amphiphilic porphyrins (4-sulfonatophenyl and aryl meso-substituted porphyrins) show several effects under the hydrodynamic forces of common stirring. These effects can be classified as pure mechanic (e. g. elasticity, plasticity and breaking of the self-assembly non-covalent bonding) and chemically selective as detected in the formation/growth of the nanoparticles. Diastereoselective, enantioselective and, depending on the sign of chiral shear forces, even enantiospecific selections have been described...
January 20, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28075063/well-covered
#11
EDITORIAL
Brian P Johnson
No abstract text is available yet for this article.
January 11, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28074599/functionalization-of-c-h-bonds-by-photoredox-catalysis
#12
REVIEW
Qixue Qin, Heng Jiang, Zhentao Hu, Daan Ren, Shouyun Yu
Visible-light photoredox catalysis has been successfully used in the functionalization of inert C-H bonds including C(sp(2) )-H bonds of arenes and C(sp(3) )-H bonds of aliphatic compounds over the past decade. These transformations are typically promoted by the process of single-electron-transfer (SET) between substrates and photo-excited photocatalyst upon visible light irradiation (household bulbs or LEDs). Compared with other synthetic strategies, such as the transition-metal catalysis and traditional radical reactions, visible-light photoredox approach has distinct advantages in terms of operational simplicity and practicability...
January 11, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28054435/azobenzene-a-photoactive-building-block-for-supramolecular-architectures
#13
REVIEW
Massimo Baroncini, Giacomo Bergamini
The development of nanoscale systems capable to perform specific functions under external control is a challenging task and a fascinating objective in Chemistry. Photochromic compounds undergo radical changes in their physico-chemical properties upon light excitation, for this reason they are valuable building blocks for the construction of photo-controllable molecular devices, machines and materials. The E-Z photoisomerization of azobenzene has been known for almost 80 years and - owing to its high efficiency and excellent reversibility - has been widely employed to introduce an element of photo-control in a large variety of compounds, biomolecules, nanosystems and materials...
January 5, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28052561/asymmetric-multicomponent-reactions-based-on-trapping-of-active-intermediates
#14
REVIEW
Dan Zhang, Wenhao Hu
Metal carbenes derived from transition metal-catalyzed decomposition of diazo compounds react with nucleophiles with heteroatoms, such as alcohols and amines, to generate highly active oxonium/ammonium ylides intermediates. These intermediates can be trapped by appropriate electrophiles to provide three-component products. Based on this novel trapping process, we have developed novel multicomponent reactions (MCRs) of diazo compounds, alcohols/anilines, and electrophiles. The nucleophiles were also extended to electron-rich heterocycles (indoles and pyrroles)/arenes, in which the resulting zwitterionic intermediates were also trapped by electrophiles...
January 4, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28052541/emerging-of-inorganic-hole-transporting-materials-for-perovskite-solar-cells
#15
REVIEW
Ramireddy Rajeswari, Madoori Mrinalini, Seelam Prasanthkumar, Lingamallu Giribabu
Hole transporting material (HTM) is a significant component to achieve the high performance perovskite solar cells (PSCs). Over the years, inorganic, organic and hybrid (organic-inorganic) material based HTMs have been developed and investigated successfully. Today, perovskite solar cells achieved the efficiency of 22.1 % with with 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenyl-amine) 9,9-spirobifluorene (spiro-OMeTAD) as HTM. Nevertheless, synthesis and cost of organic HTMs is a major challenging issue and therefore alternative materials are required...
January 4, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28042681/photodynamic-therapy-past-present-and-future
#16
REVIEW
Ushasri Chilakamarthi, Lingamallu Giribabu
Though we crossed many milestones in the field of medicine and health care in eradicating some deadly diseases over the past decades, cancer remained a challenge taking the lives of millions of people and having adverse effects on the quality of life of survivors. Chemotherapy and radiotherapy, the two existing major treatment modalities, have severe side effects and patients undergoing these treatments experience unbearable pain. Consequently, clinicians and researchers are working for the alternate treatment regimens, which can provide complete cure with minimum or no side effects...
January 2, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/27701816/morita-baylis-hillman-mbh-reaction-derived-nitroallylic-alcohols-acetates-and-amines-as-synthons-in-organocatalysis-and-heterocycle-synthesis
#17
REVIEW
Wan-Yun Huang, Shaik Anwar, Kwunmin Chen
The Morita-Baylis-Hillman (MBH) reaction is one of the most useful and efficient protocols for constructing new carbon-carbon bonds between an activated olefin and electrophiles in the presence of a tertiary amine/phosphine. Herein, we present the use of MBH alcohols, which are obtained from the reaction of nitrostyrenes with aldehydes, as well as acetates and amines derived thereof in several organocatalytic transformations. Densely functionalised MBH adducts can also be used to synthesise substituted heteroaromatic compounds, such as furan, pyrrole, pyrazole and imidazole derivatives...
March 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/27701807/lewis-base-catalyzed-stereo-and-regioselective-bromocyclization
#18
REVIEW
Matthew H Gieuw, Zhihai Ke, Ying-Yeung Yeung
Oxygen- and nitrogen-containing heterocyclic compounds are widely recognized as key components in many natural products and biologically relevant molecules, but often the problem comes down to methodologies in synthesizing them. Halocyclization of olefinic substrates is a promising strategy in the construction of O- and N-heterocyclic compounds, which further signifies the development of their asymmetric variants. Over the past years, our group has been devoted to this particular area of asymmetric electrophilic halocyclization with chalcogen-containing molecules as catalysts...
March 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/27701806/photosensitizing-electron-transfer-processes-of-fullerenes-carbon-nanotubes-and-carbon-nanohorns
#19
REVIEW
Osamu Ito
In this account, studies on the photosensitizing electron transfer of nanocarbons, such as fullerenes, single-walled carbon nanotubes (SWCNTs), and carbon nanohorns (CNH), performed in our laboratory for about 15 years in the early 21st century have been briefly reviewed. These novel nanocarbons act as excellent electron acceptors, when they are linked to light-absorbing electron donors, such as porphyrins or phthalocyanines. For such molecule-nanocarbon hybrids, the direct confirmation of fast, transient, electron-transfer phenomena must be performed with time-resolved spectroscopic methods, such as transient absorption spectral measurements, in addition to fluorescence time-profile measurements in the wide-wavelength regions...
March 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/27701805/recent-developments-in-coinage-metal-catalyzed-transformations-of-stabilized-vinyldiazo-compounds-beyond-carbenic-pathways
#20
REVIEW
Enol López, Silvia González-Pelayo, Luis A López
Transition metal-catalyzed transformations of vinyldiazo compounds have become a versatile tool in organic synthesis. Although several transition metals have been investigated for this purpose, this field has been mainly dominated by dirhodium catalysts. Remarkable levels of chemo-, regio-, diastereo- and enantioselectivity have been reached in some of these rhodium-catalyzed transformations. In the last few years coinage metals have also emerged as useful catalysts in transformations involving vinyldiazo compounds...
March 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
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