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Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]

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https://www.readbyqxmd.com/read/28444986/supported-ionic-liquids-a-versatile-and-useful-class-of-materials
#1
REVIEW
Vincenzo Campisciano, Francesco Giacalone, Michelangelo Gruttadauria
Supported ionic liquids (SILs) represent a class of materials with peculiar properties and a huge potential regarding their possible applications in different fields of chemistry. Herein, we report our ongoing research about the use of SILs as support for organocatalysts, their role as catalysts themselves, and their application as support and stabilizers of palladium nanoparticles (PdNPs). The use of SILs based materials allowed achieving good results. Moreover, in some cases, after the functionalization of the catalytic species with an ion-tag moiety, a release and catch approach was employed in order to improve the catalytic activity and to facilitate the recovery of the hybrid system formed by the catalyst adsorbed onto SILs materials...
April 26, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28418111/toward-the-dark-matter-of-natural-products
#2
REVIEW
Toshiyuki Wakimoto
Considering the dynamic features of natural products, our access toward exploring the entire diversity of natural products has been quite limited. It is challenging to assess the diversity of natural products by using conventional analytical methods, even with tandem chromatographic techniques, such as LC-MS and GC-MS. This viewpoint is supported by the sequencing analyses of microbial genomes, which have unveiled the potential of secondary metabolite production far exceeding the number of isolated molecules...
April 18, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28402607/frustrated-lewis-pair-chemistry-searching-for-new-reactions
#3
REVIEW
Gerald Kehr, Gerhard Erker
Frustrated Lewis pair chemistry has taken a steep development in the recent years. It offers possibilities of developing new variants of known reactions and of finding new chemical transformations. This is demonstrated and described by the recently developed FLP-formylborane chemistry, which has led to the formation of the unique (η(2) -formylborane)FLP adducts and opened a way of preparing a genuine formylborane compound, which shows an interesting follow-up chemistry. FLPs have helped finding phosphorus analogues of the enamine Stork reaction and the Claisen reaction...
April 12, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28394410/nanotechnology-for-electroanalytical-biosensors-of-reactive-oxygen-and-nitrogen-species
#4
REVIEW
Rajesh Seenivasan, Charles Kolodziej, Chandran Karunakaran, Clemens Burda
Over the past several decades, nanotechnology has contributed to the progress of biomedicine, biomarker discovery, and the development of highly sensitive electroanalytical / electrochemical biosensors for in vitro and in vivo monitoring, and quantification of oxidative and nitrosative stress markers like reactive oxygen species (ROS) and reactive nitrogen species (RNS). A major source of ROS and RNS is oxidative stress in cells, which can cause many human diseases, including cancer. Therefore, the detection of local concentrations of ROS (e...
April 10, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28387472/polymeric-1-h-mri-probes-for-visualizing-tumor-in-vivo
#5
REVIEW
Teruyuki Kondo, Yu Kimura, Hisatsugu Yamada, Yasuhiro Aoyama
Magnetic resonance imaging (MRI) has become a prominent non- or low-invasive imaging technique, providing high-resolution, three-dimensional images as well as physiological information about tissues. Low-molecular-weight Gd-MRI contrast agents (CAs), such as Gd-DTPA (DTPA: diethylenetriaminepentaacetic acid), are commonly used in the clinical diagnosis, while macromolecular Gd-MRI CAs have several advantages over low-molecular-weight Gd-MRI CAs, which help minimize the dose of CAs and the risk of side effects...
April 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28387469/elucidation-of-biosynthetic-pathways-of-natural-products
#6
REVIEW
Shinji Kishimoto, Yuta Tsunematsu, Michio Sato, Kenji Watanabe
During the last decade, we have revealed biosynthetic pathways responsible for the formation of important and chemically complex natural products isolated from various organisms through genetic manipulation. Detailed in vivo and in vitro characterizations enabled elucidation of unexpected mechanisms of secondary metabolite biosynthesis. This personal account focuses on our recent efforts in identifying the genes responsible for the biosynthesis of spirotryprostatin, aspoquinolone, Sch 210972, pyranonigrin, fumagillin and pseurotin...
April 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28378920/application-of-fischer-indolization-under-green-conditions-using-deep-eutectic-solvents
#7
REVIEW
Sambasivarao Kotha, Chandravathi Chakkapalli
Indole and its derivatives captured the attention of organic chemists due to their applications in medicinal chemistry. The examples covered here are intricate polycyclic indole derivatives and these include: azapolyquinanes, cyclophanes, spirocycles and other heterocycles. We found that deep eutectic mixture such as L-(+)-tartaric acid (TA) and dimethyl urea (DMU) is useful to prepare complex unnatural indole derivatives. These conditions from time to time produced indole derivatives which are not possible by conventional methods...
April 5, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28375578/platinum-group-metal-free-catalysts-for-hydrogen-evolution-reaction-in-microbial-electrolysis-cells
#8
REVIEW
Heyang Yuan, Zhen He
Hydrogen gas is a green energy carrier with great environmental benefits. Microbial electrolysis cells (MECs) can convert low-grade organic matter to hydrogen gas with low energy consumption and have gained a growing interest in the past decade. Cathode catalysts for the hydrogen evolution reaction (HER) present a major challenge for the development and future applications of MECs. An ideal cathode catalyst should be catalytically active, simple to synthesize, durable in a complex environment, and cost-effective...
April 4, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28375569/1-8-naphthalimide-a-potent-dna-intercalator-and-target-for-cancer-therapy
#9
REVIEW
Runjhun Tandon, Vijay Luxami, Harsovin Kaur, Nitin Tandon, Kamaldeep Paul
The poor pharmacokinetics, side effects and particularly the rapid emergence of drug resistance compromise the efficiency of clinically used anticancer drugs. Therefore, the discovery of novel and effective drugs is still an extremely primary mission. Naphthalimide family is one of the highly active anticancer drug based upon effective intercalator with DNA. In this article, we review the discovery and development of 1,8-naphthalimide moiety, and, especially, pay much attention to the structural modifications and structure activity relationships...
April 4, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28371211/understanding-and-practical-use-of-ligand-and-metal-exchange-reactions-in-thiolate-protected-metal-clusters-to-synthesize-controlled-metal-clusters
#10
REVIEW
Yoshiki Niihori, Sakiat Hossain, Sachil Sharma, Bharat Kumar, Wataru Kurashige, Yuichi Negishi
It is now possible to accurately synthesize thiolate (SR)-protected gold clusters (Aun (SR)m ) with various chemical compositions with atomic precision. The geometric structure, electronic structure, physical properties, and functions of these clusters are well known. In contrast, the ligand or metal atom exchange reactions between these clusters and other substances have not been studied extensively until recently, even though these phenomena were observed during early studies. Understanding the mechanisms of these reactions could allow desired functional metal clusters to be produced via exchange reactions...
March 29, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28318093/synthesis-of-imidazo-1-2-a-pyridines-c-h-functionalization-in-the-direction-of-c-s-bond-formation
#11
REVIEW
Chitrakar Ravi, Subbarayappa Adimurthy
Imidazo[1,2-a]pyridines play an important role in medicinal chemistry. In spite of very drastic developments on syntheses and functionalization in this area, the use of inexpensive catalysts and mild reaction conditions constitutes an important role in pharmaceutical applications. This account describes our recent efforts on the development of new methods for the synthesis of imidazo[1,2-a]pyridines using readily available starting substrates and catalysts under very mild reaction conditions. In the direction of enhancement of biological activity, we also described the synthesis of functionalized imidazo [1,2-a]pyridine derivatives...
March 20, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28272766/recent-developments-in-total-syntheses-of-cephalosporolides-penisporolides-and-ascospiroketals
#12
REVIEW
Hongliang Yao, Jian Wang, Rongbiao Tong
The possible biogenetic connection of the 10-membered lactone (decanolide) and the tricyclic [5,5]-spiroacetal-cis-fused-γ-lactone (SAFL) natural products was proposed by Hanson in 1985. Mimicking such biosynthetic hypothesis led us to develop a general synthetic strategy for the total syntheses of both decanolide-type cephalosporolides and SAFL-type natural products. This biomimetic strategy features two key transformations: i) oxidative ring expansion of bicyclic β-hydroxy tetrahydropyrans to the decanolides and ii) ring contraction rearrangement of the decanolides to the tricyclic SAFLs...
March 8, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28266174/synthesis-of-functionalized-pyrazoles-via-1-3-dipolar-cycloaddition-of-%C3%AE-diazo-%C3%AE-ketophosphonates-sufones-and-esters-with-electron-deficient-alkenes
#13
REVIEW
T V Baiju, Irishi N N Namboothiri
1,3-Dipolar cycloaddition of diazo compounds with olefinic substrates is a promising atom-economic strategy for the construction of functionalized pyrazoles. Over the last few years, our group has been engaged in the synthesis of phosphonyl/sulfonylpyrazoles and pyrazole esters by employing Bestmann-Ohira Reagent (BOR) and its sulfur and ester analogs as 1,3-dipole precursors with various dipolarophiles. This account describes the novel synthetic methods developed in our laboratory, in the perspective of closely related work by others, for the synthesis of phosphonyl/sulfonylpyrazoles, pyrazole esters and the total synthesis of Withasomnine, a natural product, by using 1,3-dipolar cycloaddition as the key step...
March 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28266131/squaramide-catalyzed-asymmetric-reactions
#14
REVIEW
Bo-Liang Zhao, Jun-Hua Li, Da-Ming Du
Bifunctional squaramides have emerged as powerful hydrogen-bonding catalysts for promoting a wide array of useful asymmetric reactions, which provides convenient methods for the construction of complex molecular structures and chiral biologically active compounds. This review highlights the recent advances of our research group in the chiral squaramide-catalyzed asymmetric reactions, including Michael addition, Mannich reaction, aza-Henry reaction, Strecker reaction as well as cascade or sequential reactions...
March 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28257168/thioether-derived-macrocycle-for-peptide-secondary-structure-fixation
#15
REVIEW
Yuan Tian, Dan Yang, Xiyang Ye, Zigang Li
Recently, we developed methods to stabilize peptides into various secondary structures, including α-helix, type III turn and β-hairpin via proper thioether based macrocyclization. These conformationally constrained peptidomimetics confer enhanced biophysical properties and provide a valuable avenue towards clinically-relevant therapeutic molecules. In this personal account, thioether-derived macrocyclization methods developed by our group for stabilization of α-helix, type-III β turn and β-hairpin conformations are discussed...
March 3, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28245339/towards-more-efficient-greener-syntheses-through-flow-chemistry
#16
REVIEW
Justin A M Lummiss, Peter D Morse, Rachel L Beingessner, Timothy F Jamison
Technological advances have an important role in the design of greener synthetic processes. In this Personal Account, we describe a wide range of thermal, photochemical, catalytic, and biphasic chemical transformations examined by our group. Each of these demonstrate how the merits of a continuous flow synthesis platform can align with some of the goals put forth by the Twelve Principles of Green Chemistry. In particular, we illustrate the potential for improved reaction efficiency in terms of atom economy, product yield and reaction rates, the ability to design synthetic process with chemical and solvent waste reduction in mind as well as highlight the benefits of the real-time monitoring capabilities in flow for highly controlled synthetic output...
February 28, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28195390/self-assembly%C3%A2-of%C3%A2-renewable%C3%A2-nano-sized-triterpenoids
#17
REVIEW
Braja Gopal Bag, Rakhi Majumdar
Studies on plant metabolites have gained renewed interest in recent years because these can serve as renewable chemicals for the development of a sustainable society.Among various plant secondary metabolites, terpenoids constitute the major component and triterpenoids are the 30C subset of it.In recent years, triterpenoids have drawn the attention of scientific community due to many of its potential and realized applications in medicine, drug delivery, thermochromic materials, pollutant capture, catalysis, liquid crystals, etc...
February 14, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28169484/organocatalytic-hydrophosphonylation-reaction-of-carbonyl-groups
#18
REVIEW
Raquel P Herrera
This revision is covering the limited examples reported for a pivotal strategy in the formation of C-P bonds such as the asymmetric organocatalytic hydrophosphonylation of carbonyl groups (Pudovik reaction). The scope and limitations, and the proposed mechanisms for the scarce different possibilities of asymmetric induction are also shown. The recent evolution and future trends of this undeveloped approach are commented.
February 7, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28146343/catalytic-reaction-assisted-by-plasma-or-electric-field
#19
REVIEW
Shuhei Ogo, Yasushi Sekine
Direct conversion of methane, other hydrocarbons, and alcohol at lower temperatures can be achieved using plasma or an electric field and catalysts. Non-equilibrium plasma enables activation of stable molecules including methane, carbon dioxide, and water, even at low temperatures, by virtue of high electron energy. Use of a hybrid system of plasma and catalyst provided high conversion and selectivity to products by virtue of adsorption on the catalyst. Imposing a DC electric field to the catalyst bed also promotes catalytic reactions, even at low temperatures...
February 1, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/27701816/morita-baylis-hillman-mbh-reaction-derived-nitroallylic-alcohols-acetates-and-amines-as-synthons-in-organocatalysis-and-heterocycle-synthesis
#20
REVIEW
Wan-Yun Huang, Shaik Anwar, Kwunmin Chen
The Morita-Baylis-Hillman (MBH) reaction is one of the most useful and efficient protocols for constructing new carbon-carbon bonds between an activated olefin and electrophiles in the presence of a tertiary amine/phosphine. Herein, we present the use of MBH alcohols, which are obtained from the reaction of nitrostyrenes with aldehydes, as well as acetates and amines derived thereof in several organocatalytic transformations. Densely functionalised MBH adducts can also be used to synthesise substituted heteroaromatic compounds, such as furan, pyrrole, pyrazole and imidazole derivatives...
March 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
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