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Journal of Musculoskeletal & Neuronal Interactions

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https://www.readbyqxmd.com/read/28860427/feasibility-and-acceptability-of-using-jumping-mechanography-to-detect-early-components-of-sarcopenia-in-community-dwelling-older-women
#1
K Hannam, A Hartley, E M Clark, A Aihie Sayer, J H Tobias, C L Gregson
OBJECTIVE: To determine the feasibility and acceptability of using peak power and force, measured by jumping mechanography (JM), to detect early age-related features of sarcopenia in older women. METHODS: Community-dwelling women aged 71-87 years were recruited into this cross-sectional study. Physical function tests comprised the short physical performance battery (SPPB), grip strength and, if SPPB score≥6, JM. JM measured peak weight-adjusted power and force from two-footed jumps and one-legged hops respectively...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860426/experience-with-jumping-mechanography-in-children-with-cerebral-palsy
#2
I Duran, K Martakis, C Stark, E Alberg, C Bossier, O Semler, E Schoenau
OBJECTIVES: Jumping mechanography provides robust motor function indicators among healthy children. The aim of the study was to assess the reproducibility and validity of jumping mechanography conducted as single two-legged jump (S2LJ) in children with cerebral palsy (CP). METHODS: 215 S2LJ investigations from a sample of 75 children with CP were eligible for evaluation. For the estimation of the reproducibility, only the baseline set of data per patient were used...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860425/marked-expression-of-tnf-receptors-in-human-peritendinous-tissues-including-in-nerve-fascicles-with-axonal-damage-studies-on-tendinopathy-and-tennis-elbow
#3
C Spang, L Renström, H Alfredson, S Forsgren
BACKGROUND: The peritendinous connective tissues can have importance in chronic tendon pain. Recently cytokine TNF-α has been suggested to be involved in tendinopathic processes. It is not known how TNF-α and its receptors TNFR1 and TNFR2 are expressed in peritendinous tissues. METHODS: The objective for this study was to immunohistochemically evaluate the expression patterns of these in the peritendinous tissue located between the plantaris and Achilles tendons and the one located superficially to the extensor origin at the elbow region for patients with tendinopathy/tennis elbow...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860424/prolonging-disuse-in-aged-mice-amplifies-cortical-but-not-trabecular-bones-response-to-mechanical-loading
#4
R DeSouza, B Javaheri, R S Collinson, C Chenu, S J Shefelbine, P D Lee, A A Pitsillides
OBJECTIVE: Short-term neurectomy-induced disuse (SN) has been shown to restore load responses in aged mice. We examined whether this restoration was further enhanced in both cortical and trabecular bone by simply extending the SN. METHODS: Following load:strain calibration, tibiae in female C57BL/J6 mice at 8, 14 and 20 weeks and 18 months (n=8/group) were loaded and bone changes measured. Effects of long-term SN examined in twenty-six 18 months-old mice, neurectomised for 5 or 100 days with/without subsequent loading...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860423/prevalence-of-sarcopenia-in-a-population-of-nursing-home-residents-according-to-their-frailty-status-results-of-the-senior-cohort
#5
F Buckinx, J Y Reginster, T Brunois, C Lenaerts, C Beaudart, J L Croisier, J Petermans, O Bruyère
OBJECTIVE: To investigate the relationship between frailty and sarcopenia, by evaluating the prevalence of sarcopenia among frail, pre-frail and robust elderly nursing home residents in Belgium. METHODS: This is an analysis of baseline data collected from the SENIOR (Sample of Elderly Nursing home Individuals: an Observational Research) cohort. All subjects received a sarcopenia evaluation, based on the definition proposed by the European Working Group on Sarcopenia in Older People (EWGSOP)...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860422/intertester-and-intratester-reliability-of-a-movement-control-test-battery-for-patients-with-knee-osteoarthritis-and-controls
#6
P T Kaukinen, J P Arokoski, E O Huber, H A Luomajoki
OBJECTIVES: To develop a test battery of movement control (MC) tests and assess its intertester and intratester reliability. METHODS: 29 subjects with knee OA with mean age of 64.7 (SD 8.7) years and 12 controls without either knee pain or previous diagnosis of OA (mean age 36.6 (SD 16.2) years) were included. Two experienced physiotherapists rated the filmed test performance of six MC tests blinded to the patients and to each other on 3-point scale as correct, incorrect or failed...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860421/relationship-of-body-anthropometric-measures-with-skeletal-muscle-mass-and-strength-in-a-reference-cohort-of-young-finnish-women
#7
S L Qazi, T Rikkonen, H Kröger, R Honkanen, M Isanejad, O Airaksinen, J Sirola
OBJECTIVES: 1) To study if limb length explains variability in appendicular and total muscle mass better than height and 2) if muscle mass adjusted for limb length rather than height correlates better with grip and knee extension strength. METHODS: 400 healthy women aged 20-40 were recruited as a reference population. Body composition, limb length, grip strength and knee extension strength were measured. New relative muscle mass indexes were computed by adjusting upper limb muscle mass for upper limb length (ULRSMI) and lower limb muscle mass for lower limb length (LLRSMI)...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860420/baseline-mineralizing-surface-determines-the-magnitude-of-the-bisphosphonate-effect-on-cortical-bone-mineralization-in-postmenopausal-osteoporotic-patients
#8
B M Misof, S Blouin, S Lueger, E P Paschalis, R R Recker, R Phipps, K Klaushofer, P Roschger
PURPOSE: To determine the effect of short- or long-term bisphosphonate treatment on cortical bone mineralization density distribution (BMDD). METHODS: BMDD was assessed by quantitative backscatter electron imaging in postmenopausal osteoporosis: in paired transiliac biopsy samples (n=36) at baseline and after 3 years risedronate treatment from a clinical study, in transiliac biopsy samples from patients who were treated with either risedronate (n=31) or alendronate (n=68) for 3 to 7 years from an observational study...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860419/effect-of-quadriceps-and-hamstrings-muscle-cooling-on-standing-balance-in-healthy-young-men
#9
A H Alghadir, S Anwer, H Zafar, E S Al-Eisa
OBJECTIVE: The present study compared the effect of quadriceps and hamstring muscle cooling on standing balance in healthy young men. METHODS: Thirty healthy young men (18-30 years) participated in the study. The participants were randomly assigned to three groups (n=10 each): quadriceps cooling (QC), hamstring cooling (HC), or control group (no cooling). Participants in the QC and HC groups received 20 minutes of cooling using a cold pack (gel pack), placed on the anterior thigh (from the apex of the patella to the mid-thigh) and the posterior thigh (from the base of the popliteal fossa to the mid-thigh), respectively...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860418/pantoprazole-a-proton-pump-inhibitor-does-not-prevent-botulinum-toxin-induced-disuse-osteopenia-in-mice
#10
J B Vegger, A Brüel, J S Thomsen
OBJECTIVES: Pantoprazole is a proton pump inhibitor that has been shown to inhibit bone resorption. The aim of the study was to investigate whether pantoprazole can prevent development of botulinum toxin (BTX)-induced disuse osteopenia in mice. METHODS: Forty-eight 16-week-old female C57BL/6J mice were randomized into 4 groups (n=12): Base, Ctrl, BTX, and BTX+Pan. The Base group was euthanized at study start. The BTX and BTX+Pan groups were immobilized by injections with BTX in one hind limb...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860417/exercise-for-osteoporosis-how-to-navigate-between-overeagerness-and-defeatism
#11
A Ireland, J J Rittweger
Osteoporosis and associated fractures remain a common and costly health problem. Public fears about rare side effects of efficacious drug treatments for osteoporosis have contributed to decreased prescription and compliance. Exercise and physical activity-based interventions have long been proposed as an alternative treatment for osteoporosis. However despite compelling evidence from experimental studies in animals and from observational studies in humans, the use of exercise to improve bone mass in clinical practice does not seem to be justifiable by current human interventional studies...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860416/estrogen-progestin-therapy-causes-a-greater-increase-in-spinal-bone-mineral-density-than-estrogen-therapy-a-systematic-review-and-meta-analysis-of-controlled-trials-with-direct-randomization
#12
J C Prior, V R Seifert-Klauss, D Giustini, J D Adachi, S Kalyan, A Goshtasebi
OBJECTIVE: To assess whether progesterone (P4) or osteoblast P4 receptor-acting progestin (P) contributed to estrogen (E) therapy-related increased areal bone mineral density (BMD) in randomized controlled trials (RCT) with direct randomization to estrogen (ET) or estrogen-progestin (EPT) therapy. METHODS: Systematic literature searches in biomedical databases identified RCT with direct randomization and parallel estrogen doses that measured spinal BMD change/year...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860415/t2-relaxation-time-increases-in-lumbar-intervertebral-discs-after-21d-head-down-tilt-bed-rest
#13
T Koy, B Ganse, J Zange, J Rittweger, R Pohle-Fröhlich, P Fings-Meuthen, B Johannes, D Felsenberg, P Eysel, P M Bansmann, D L Belavý
OBJECTIVES: Spaceflight back pain and intervertebral disc (IVD) herniations cause problems in astronauts. Purpose of this study was to assess changes in T2-relaxation-time through MRI measurements before and after head-down tilt bed-rest, a spaceflight analog. METHODS: 8 men participated in the bed-rest study. Subjects remained in 6° head down tilt bed-rest in two campaigns of 21 days, and received a nutritional intervention (potassium bicarbonate 90 mmol/d) in a cross-over design...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28860414/mechanical-basis-of-bone-strength-influence-of-bone-material-bone-structure-and-muscle-action
#14
N H Hart, S Nimphius, T Rantalainen, A Ireland, A Siafarikas, R U Newton
This review summarises current understanding of how bone is sculpted through adaptive processes, designed to meet the mechanical challenges it faces in everyday life and athletic pursuits, serving as an update for clinicians, researchers and physical therapists. Bone's ability to resist fracture under the large muscle and locomotory forces it experiences during movement and in falls or collisions is dependent on its established mechanical properties, determined by bone's complex and multidimensional material and structural organisation...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28574418/clinical-study-on-the-arthroscopic-refreshing-treatment-of-anterior-cruciate-ligament-injury-combined-with-stable-medial-meniscus-ramp-injury
#15
J Yang, K Guan, J Z Wang
This study sought to investigate the clinical efficacy of arthroscopic refreshing treatment of anterior cruciate ligament (ACL) injury combined with stable medial meniscus ramp injury. Sixty-eight patients treated between January 2010 and January 2014 were included, and their clinical data were retrospectively analyzed. All patients, after being treated using ACL reconstruction, were divided into 2 groups according to meniscus injury treatment method. The observation group (31 cases) was treated by arthroscopic refreshing, which removed the tissue on both sides of the tear edge using a cutting knife, while the control group (37 cases) was treated using Fast-fix sutures...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28574417/study-on-the-expression-of-nerve-growth-associated-protein-43-in-rat-model-of-intervertebral-disc-degeneration
#16
H Jiang, J Wang, B Xu, Q Yang, Y Liu
OBJECTIVE: In the present work we studied the expression of nerve growth associated protein (GAP-43) in a rat model of intervertebral disc degeneration. METHODS: 16 healthy adult SD rats, male or female, with an average weight 220g were selected. FluoroGold was injected in L5-L6 disc as the tracer. After 7 days, Freund's adjuvant was then injected to build model of intervertebral disc degeneration. After 1, 3, 7 and 14 days of modeling immune-histochemical method was used to detect the T13-L6 dorsal root ganglion and positive expression of GAP-43, TNF-α and IL-1 in L5-L6 intervertebral disc; RT-PCR method was used to detect GAP-43 mRNA and Western blot method was utilized to detect the expression levels of protein...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28574416/richly-innervated-soft-tissues-covering-the-superficial-aspect-of-the-extensor-origin-in-patients-with-chronic-painful-tennis-elbow-implication-for-treatment
#17
C Spang, H Alfredson
BACKGROUND: Tennis elbow is difficult to treat. The results of surgical treatments are not convincing. Treatment studies on Achilles and patellar tendinopathy targeting the richly innervated and vascularized soft tissues outside the tendon have shown promising outcomes. The innervation patterns in the fibrous/fatty tissues superficially to the elbow extensor origin have not been clarified. METHODS: Nine tissue specimens from the fibrous/fatty tissue covering the extensor origin was taken from seven patients (mean age: 45 years) undergoing surgical treatment for chronic painful tennis elbow...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28574415/a-novel-interpolation-approach-for-the-generation-of-3d-geometric-digital-bone-models-from-image-stacks
#18
U Mittag, A Kriechbaumer, J Rittweger
The authors propose a new 3D interpolation algorithm for the generation of digital geometric 3D-models of bones from existing image stacks obtained by peripheral Quantitative Computed Tomography (pQCT) or Magnetic Resonance Imaging (MRI). The technique is based on the interpolation of radial gray value profiles of the pQCT cross sections. The method has been validated by using an ex-vivo human tibia and by comparing interpolated pQCT images with images from scans taken at the same position. A diversity index of ⟨0...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28574414/impaired-fracture-healing-with-high-non-union-rates-remains-irreversible-after-traumatic-brain-injury-in-leptin-deficient-mice
#19
F Graef, R Seemann, A Garbe, K Schmidt-Bleek, K D Schaser, J Keller, G Duda, S Tsitsilonis
Patients with traumatic brain injury (TBI) and long-bone fractures can show increased callus formation. This effect has already been reproduced in wild-type (wt) mice. However, the mechanisms remain poorly understood. Leptin is significantly increased following TBI, while its role in bone healing remains unclear. The aim of this study was to evaluate fracture healing in leptin-deficient ob/ob mice and to measure any possible impact of TBI on callus formation. 138 female, 12 weeks old, ob/ob mice were divided into four groups: Control, fracture, TBI and combined trauma...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28574413/effect-of-acetylcholinesterase-inhibitors-on-post-surgical-complications-and-mortality-following-a-hip-fracture-a-cohort-study
#20
I Tamimi, S A Madathil, A Kezouh, B Nicolau, I Karp, F Tamimi
There is increasing evidence suggesting that the use of acetylcholinesterase inhibitors may have beneficial effects on bone. Data on the potential post-surgical effects of these medications on orthopedic interventions are very limited. This study was designed to determine whether the use of acetylcholinesterase inhibitors is associated with a decrease in post-surgical mortality and complications in hip fracture patients with Alzheimer's disease. To accomplish this objective, a retrospective cohort study was performed using data from the Clinical Practice Research Database, UK...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
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