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Journal of Musculoskeletal & Neuronal Interactions

F Zou, J-C Xu, G-H Wu, L-L Zhou, Q-D Wa, J-Q Peng, X-N Zou
OBJECTIVE: To explore the effects of protein factor Oncostatin M (OSM), a member of the Interleukin-6 (IL-6) family on cell proliferation, osteogenic differentiation and mineralization. MATERIALS AND METHODS: Basal nutrient solutions of different concentrations of OSM (0, 5, 10, 20, 40, 80 ng/ml) were used. In order to divide embryonic origin between mesenchymal stem cells C3H10T1/2 of in vitro cultured mice, and the effects of in vitro proliferation efficiencies of C3H10T1/2 cells of different concentrations of OSM, the C3H10T1/2 cells were divided into four groups: (1) Basal nutrient solution group (negative control); (2) Osteogenesis induced liquid group (positive control); (3) OSM (20 ng/ml) group; (4) Experimental group (osteogenesis induced liquid + OSM (20 ng/ml))...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
R D Brady, B L Grills, T Romano, J D Wark, T J O'Brien, S R Shultz, S J McDonald
OBJECTIVES: Administration of sodium selenate to rats given traumatic brain injury (TBI) attenuates brain damage and improves long-term behavioural outcomes. We have previously provided evidence that TBI causes bone loss in rats, however the effect of sodium selenate treatment on bone quantity following TBI is unknown. METHODS: Rats were randomly assigned into sham injury or fluid percussion injury (FPI) groups and administered saline or sodium selenate for 12 weeks post-injury...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
J B Vegger, A Brüel, A F Dahlgaard, J S Thomsen
OBJECTIVES: To investigate alteration of bone and muscle gene expression at different time points during 3 weeks of botulinum toxin (BTX) induced immobilization and how this correlate with conventional analysis of bone and muscle. METHODS: Thirty-five 16-week-old female C57BL/6-mice were investigated; 15 were injected with BTX, 15 served as age-matched controls, and 5 as baseline. 5 BTX-injected and 5 control mice were euthanized after 1, 2, and 3 weeks. Analysis included RT-qPCR, dynamic bone histomorphometry, DEXA, µCT, mechanical testing, and muscle cell cross-sectional-area (CSA)...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
A Saito, K Okada, I Saito, K Kinoshita, A Seto, Y Takahashi, K Shibata, H Sato, M Wakasa
OBJECTIVES: To clarify the functional status of the articularis genus muscle (AGM) in individuals with knee osteoarthritis (OA) and to analyze the muscle's relationship with knee OA. METHODS: Fifty-two individuals with knee OA (mean age, 73.4 years), 50 elderly individuals without knee OA changes (mean age, 71.2 years) and 75 young individuals (mean age, 20.2 years) were observed the AGM using ultrasonography. The thickness of the AGM, the anteroposterior distance of the suprapatellar bursa, and moving distance of the muscle insertion were measured both at rest and during isometric contraction, and values during contraction were expressed as percentages of the values at rest (%Muscle-Increase, %Bursa-Increase)...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
C I Morse, J Smith, A Denny, J Tweedale, N D Searle, K Winwood, G L Onambele-Pearson
OBJECTIVES: To compare muscle and bone health markers in adult males (aged 20-59 yrs) with and without muscular dystrophy (MD). METHODS: Participants included 11 Fascioscapulohumeral (FSH), 11 Becker's (Be), 9 limb girdle (LG), 11 Duchenne (DMD), and 14 non-dystrophic controls (CTRL). Physical activity was assessed using Bone (BPAQ) and disability specific (PASIPD) questionnaires. Bone QUS provided T- and Z scores from the Distal Radius (DR) and Mid-shaft tibia (MST)...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
A Krause, A Gollhofer, K Freyler, L Jablonka, R Ritzmann
OBJECTIVES: The objective of this study was to investigate neural effects of acute whole body vibration (WBV) on lower limb muscles regarding corticospinal and spinal excitability. METHODS: In 44 healthy subjects (16 f/ 28 m), motor evoked potentials (MEP) and H-reflexes in m. soleus (SOL) and gastrocnemius medialis (GM) were elicited before (t1), immediately after (t2), 2 (t3), 4 (t4) and 10 min after (t5) WBV. RESULTS: After WBV, MEP amplitudes were significantly increased in SOL (t2+15±30%, t3+22±32%, t4+15±35%, t5+20±30%, P<0...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
C M Smith, T J Housh, E C Hill, K C Cochrane, N Dm Jenkins, R J Schmidt, G O Johnson
OBJECTIVE: To determine the effects of constant versus alternating applications of torque during fatiguing, intermittent isometric muscle actions of the leg extensors on maximal voluntary isometric contraction (MVIC) torque and neuromuscular responses. METHODS: Sixteen subjects performed two protocols, each consisting of 50 intermittent isometric muscle actions of the leg extensors with equal average load at a constant 60% MVIC or alternating 40 then 80% (40/80%) MVIC with a work-to-rest ratio of 6-s on and 2-s off...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
E C Hill, T J Housh, C M Smith, K C Cochrane, N Dm Jenkins, J T Cramer, R J Schmidt, G O Johnson
OBJECTIVE: The purpose of the present investigation was to examine the effect of sex on maximal voluntary isometric contraction (MVIC) torque and the EMG and MMG responses as a result of fatiguing, intermittent, submaximal (65% of MVIC), isometric elbow flexion muscle contractions. METHODS: Eighteen men and women performed MVIC trials before (pretest), after (posttest), and 5-min after (5-min recovery) performing 50 intermittent, submaximal isometric muscle contractions...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
T Gysel, C Tonoli, S Pardaens, D Cambier, J-M Kaufman, H-G Zmierczak, S Goemaere, B Lapauw, P Calders
OBJECTIVES: This study investigated whether an association between insulin resistance (IR) and muscle parameters is appreciable in young healthy men, independent of obesity. Furthermore, markers of muscle metabolism and hormones/possible determinants, were explored. METHODS: 358 healthy young men were divided into a less and more insulin sensitive (LIS [age=33.2±5.4, BMI=23.4±2.3] and MIS [age=35.5±5.3, BMI=28.1±3.7]) group based on upper and lower quartile of HOMA-IR...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
T Abe, R S Thiebaud, J P Loenneke
OBJECTIVES: To examine the associations between absolute and relative handgrip strength (HGS) and physical performance. METHODS: A total of 135 old men aged 70-89 years had muscle thickness (MT) measured by ultrasound at anterior forearm (MT-ulna). Maximum voluntary HGS was measured for the dominant hand. Relative HGS was calculated as ratios of HGS to MT-ulna (HGS/MT-ulna, kg/cm), HGS to forearm girth (HGS/forearm-girth, kg/cm), and HGS to body mass (HGS/body mass, kg/kg)...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
L Gabel, H M Macdonald, L Nettlefold, D Race, H A McKay
OBJECTIVES: To provide age- and sex-specific reference data for mechanography-derived parameters of muscle function in Canadian children and youth using the single two-legged jump (S2LJ) with hands-on-waist. METHODS: Our sample included 2017 observations from 715 participants (9-21 years; 338 girls). Participants performed three S2LJ with hands-on-waist on a force platform (Leonardo Mechanograph, Novotec). Outcomes were maximum peak power (Pmax), Pmax/mass, peak force/body weight (Fmax/BW), force efficiency, maximum jump height (Hmax), and velocity (Vmax)...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
A K Wong
The choice of an appropriate imaging technique to quantify bone, muscle, or muscle adiposity needs to be guided by a thorough understanding of its competitive advantages over other modalities balanced by its limitations. This review details the technical machinery and methods behind peripheral quantitative computed tomography (pQCT), high-resolution (HR)-pQCT, and magnetic resonance imaging (MRI) that drive successful depiction of bone and muscle morphometry, densitometry, and structure. It discusses a number of image acquisition settings, the challenges associated with using one versus another, and compares the risk-benefits across the different modalities...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
I D Papanastassiou, M A Gerochristou, C P Zafeiris, I Patoulias, D Ntallas, D Isaakidis, G Papageorgiou
No abstract text is available yet for this article.
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
R Schleip, W Klingler, S Wearing, I Naylor, M Zuegel, K Hoppe
INTRODUCTION: While two laboratory techniques are commonly used to assess the tensile properties of muscle tissue, emerging evidence suggests that the fascial components of these tissues also serve an active role in force generation. Hence, we investigated whether these techniques are sensitive for assessment of fascial micromechanics. METHODS: Force measurements on dissected fascial tissue were performed either using the classical immersion organ bath or using an improved superfusion approach simulating pulsed pharmacological triggers...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
D Manousaki, F Rauch, G Chabot, J Dubois, M Fiscaletti, N Alos
OBJECTIVES: Knowledge of physiological variations of bone mineral density (BMD) in newborns and infants is necessary to evaluate pathological changes associated with fractures. Limited reference data for children under 5 years old are available. This study provides normative data of lumbar BMD for the Lunar Prodigy in young children under 5 years old. SUBJECTS AND METHODS: We assessed cross-sectionally 155 healthy children (77 boys, 80% Caucasian), ranging in age from newborn to the age of 5 years...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
A G Culvenor, H Boeth, G Diederichs, W Wirth, G Duda, F Eckstein
OBJECTIVES: To explore changes in bone, muscle and adipose tissue composition in athletes with high physical activity levels at different stages of life. METHODS: Thigh MRIs were acquired at baseline and 2-year follow-up for 20 young (16±1 years) and 20 mature (46±5 years) athletes (10 males, 10 females, respectively). Longitudinal changes in cross-sectional areas (CSAs) of femoral bone, quadriceps muscle, and thigh subcutaneous (SCF) and intermuscular (IMF) adipose tissue were evaluated...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
M P Yavropoulou, J G Yovos
The skeleton has the ability to perfectly adapt to external forces of the operating environment, by altering its morphology and metabolism in order to meet different needs. This unique adaptive capacity of the skeleton creates an interesting range of biological questions concerning the perception of mechanical or other kinds of signals, the type of receptor, and the molecular pathways involved in this adaptation. Studies of the characteristics of the cellular engineering provide a host of new information that confers to osteocytes the role of the protagonist in the perception and regulation of mechanical effects on the skeleton...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
A Benoit, T Mustafy, I Londono, G Grimard, C-E Aubin, I Villemure
Fusionless devices are currently designed to treat spinal deformities such as scoliosis by the application of a controlled mechanical loading. Growth modulation by dynamic compression was shown to preserve soft tissues. The objective of this in vivo study was to characterize the effect of static vs. dynamic loading on the bone formed during growth modulation. Controlled compression was applied during 15 days on the 7(th) caudal vertebra (Cd7) of rats during growth spurt. The load was sustained in the "static" group and sinusoidally oscillating in the "dynamic" group...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
M T García-Gutiérrez, T J Hazell, P J Marín
OBJECTIVES: To evaluate the effects of whole-body vibration (WBV) on skeletal muscle activity and power performance of the upper body during decline bench press exercise at different loads. METHODS: Forty-seven healthy young and active male students volunteered. Each performed dynamic decline bench press repetitions with and without WBV (50 Hz, 2.2 mm) applied through a hamstring bridge exercise at three different loads of their 1-repetition maximum (1RM): 30%, 50%, and 70% 1RM...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
C F Dionello, D Sá-Caputo, H Vfs Pereira, C R Sousa-Gonçalves, A I Maiworm, D S Morel, E Moreira-Marconi, L L Paineiras-Domingos, D Bemben, M Bernardo-Filho
OBJECTIVES: The aim of this study was to review the literature about the effect of whole body vibration exercise in the BMD in patients with postmenopausal osteoporosis without medications. METHODS: A systematic review was performed. RESULTS: The frequency of the mechanical vibration used in the protocols has varied from 12 to 90 Hz. The time used in the protocols varied from 2 up to 22 months. Techniques with X-rays were used in nine of the twelve publications analyzed, the Dual energy X-ray absorptiometry (DEXA) in eight studies and the High resolution peripheral quantitative computed tomography (HR-pQCT) in one publication...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
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