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Journal of Musculoskeletal & Neuronal Interactions

K Tolis, I K Triantafyllopoulos, S Tournis, N A Papaioannou
No abstract text is available yet for this article.
March 2016: Journal of Musculoskeletal & Neuronal Interactions
K Lampropoulou-Adamidou, S Tournis, I K Triantafyllopoulos
There are numerous studies presenting the beneficial effect of bisphosphonates (BPs) on bone disease of patients suffering from beta-thalassemia major (TM). Although BPs have been widely used, adverse events have been described including atypical femoral fractures (AFF). In the present case, a male adult patient suffering from TM sustained an AFF fulfilling all major and two minor criteria. Before AFF, the patient had been treated with zoledronic acid for three years and remained another one year without osteoporosis therapy...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
T Lyytinen, T Bragge, M Hakkarainen, T Liikavainio, P A Karjalainen, J P Arokoski
OBJECTIVES: To determine the repeatability of knee joint impulsive loading measurements with skin-mounted accelerometers (SMAs) and lower limb surface electromyography (EMG) recordings during gait. METHODS: Triaxial SMA and EMG from 4 muscles during level and stair walking in nine healthy and nine knee osteoarthritis (OA) subjects were used. The initial peak acceleration (IPA), root mean square (RMS), maximal acceleration transient rate (ATRmax) and mean EMG activity (EMGact) were calculated...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
N J Cronin, A M Valtonen, B Waller, T Pöyhönen, J Avela
BACKGROUND: Reflex excitability is increased in hemiplegic patients compared to healthy controls. One challenge of stroke rehabilitation is to decrease the effects of hyperreflexia, which may be possible with water immersion. Methods/Aims: The present study examined the effects of acute water immersion on electrically-evoked Hmax:Mmax ratios (a measure of reflex excitability) in 7 hyperreflexive hemiplegic patients and 7 age-matched healthy people. Hmax:Mmax ratios were measured from soleus on dry land (L1), immediately after (W1) and 5 minutes after immersion (W5), and again after five minutes on land (L5)...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
R Pacheco-Costa, H M Davis, E G Atkinson, E Katchburian, L I Plotkin, R D Reginato
OBJECTIVE: To investigate whether osteocytic connexin 43 (Cx43) is required for the bone response to intermittent PTH administration, and whether the connexin is involved in maintaining the bone matrix. METHODS: Human PTH(1-34) was injected to adult male mice expressing (Cx43(fl/fl)) or not osteocytic Cx43 (Cx43(fl/fl);DMP1-8kb-Cre) daily (100 µg/kg/d) for 14 days. RESULTS: Cx43(fl/fl);DMP1-8kb-Cre mice have no difference in body weight and BMD from 1 to 4 months of age...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
G J Farkas, N Shakoor, G L Cvetanovich, L F Fogg, A A Espinoza Orías, S J Nho
OBJECTIVE: Sensory deficits, measured through vibratory perception threshold (VPT), have been recognized in hip and knee osteoarthritis (OA), but have not been evaluated in femoroacetabular impingement (FAI), thought to be a pre-OA condition. This study aimed to assess VPT in symptomatic FAI pre- and 6-months post-arthroscopy vs. METHODS: FAI patients and controls were assessed for VPT at the first metatarsophalangeal joint. Pain was assessed using a visual analog pain scale...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
W Burnett, S Kontulainen, C McLennan, D Hazel, C Talmo, D Hunter, D Wilson, J Johnston
OBJECTIVE: To determine differences in patellar subchondral bone mineral density (BMD) between knee osteoarthritis (OA) patients with differing levels of pain at rest. METHODS: The preoperative knee of 41 total knee replacement (TKR) patients was scanned using QCT and scored for pain using Western Ontario McMasters Osteoarthritis Index (WOMAC). 'Pain at rest' was defined as average pain while lying//sitting and nocturnal pain. Participants were divided into groups: 'mild-to-no pain at rest' and 'moderate-to-severe pain at rest'...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
H Hoyer-Kuhn, J Franklin, G Allo, M Kron, C Netzer, P Eysel, B Hero, E Schoenau, O Semler
OBJECTIVES: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to bone fragility. Denosumab as a RANK ligand antibody inhibiting osteoclast maturation has been approved for osteoporosis treatment in adults. Aim of this study was a 48-week, open-label, pilot study of the safety and efficacy of denosumab in 10 children with OI. METHODS: Ten patients (age range: 5.0-11.0 years; at least two years of prior bisphosphonate treatment) with genetically confirmed OI were studied...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
T L Binkley, B L Specker
OBJECTIVE: Effects of time in moderate to vigorous physical activity (MVPA) and sitting (SIT) on bone were tested, hypothesizing that high MVPA would be positively associated with bone size and strength, offset effects of high SIT, and be mediated by lean mass. METHODS: 155 children (79 male, 58 pubertal), 6-20 years (10.2±3.5 yr) were measured by dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). MVPA and SIT were measured by 7-day activity recall...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
M A Hernandez-Mocholi, F J Dominguez-Muñoz, H Corzo, S Cs Silva, J C Adsuar, N Gusi
OBJECTIVES: Loss of foot sensitivity is a relevant parameter to assess and prevent in several diseases. It is crucial to determine the vibro-tactile sensitivity threshold response to acute conditions to explore innovative monitor tools and interventions to prevent and treat this challenge. The aims were: 1) to analyze the acute effects of a single whole body vibration session (4min-18Hz-4mm) on vibro-tactile perception threshold in healthy young adults. 2) to analyze the 48 hours effects of 3 whole body vibration sessions on vibro-tactile perception threshold in healthy young adults...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
W-H Cheung, C-Y Li, T Y Zhu, K-S Leung
OBJECTIVES: To investigate the effects on muscle performance after one-year cessation of 18-month low-magnitude high-frequency vibration (LMHFV) intervention in the untrained community elderly. METHODS: This is a case-control study with 59 community elderly women (25 control without any treatment; 34 received 18-month LMHFV but discontinued for 1 year from our previous clinical study). Muscle strength, balancing ability, occurrence of fall/fracture, quality of life (QoL) were assessed 1-year after cessation of intervention...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
A Ireland
No abstract text is available yet for this article.
March 2016: Journal of Musculoskeletal & Neuronal Interactions
I D Papanastassiou, M A Gerochristou, C P Zafeiris, I Patoulias, D Ntallas, D Isaakidis, G Papageorgiou
No abstract text is available yet for this article.
2016: Journal of Musculoskeletal & Neuronal Interactions
R Schleip, W Klingler, S Wearing, I Naylor, M Zuegel, K Hoppe
INTRODUCTION: While two laboratory techniques are commonly used to assess the tensile properties of muscle tissue, emerging evidence suggests that the fascial components of these tissues also serve an active role in force generation. Hence, we investigated whether these techniques are sensitive for assessment of fascial micromechanics. METHODS: Force measurements on dissected fascial tissue were performed either using the classical immersion organ bath or using an improved superfusion approach simulating pulsed pharmacological triggers...
2016: Journal of Musculoskeletal & Neuronal Interactions
D Manousaki, F Rauch, G Chabot, J Dubois, M Fiscaletti, N Alos
OBJECTIVES: Knowledge of physiological variations of bone mineral density (BMD) in newborns and infants is necessary to evaluate pathological changes associated with fractures. Limited reference data for children under 5 years old are available. This study provides normative data of lumbar BMD for the Lunar Prodigy in young children under 5 years old. SUBJECTS AND METHODS: We assessed cross-sectionally 155 healthy children (77 boys, 80% Caucasian), ranging in age from newborn to the age of 5 years...
2016: Journal of Musculoskeletal & Neuronal Interactions
A G Culvenor, H Boeth, G Diederichs, W Wirth, G Duda, F Eckstein
OBJECTIVES: To explore changes in bone, muscle and adipose tissue composition in athletes with high physical activity levels at different stages of life. METHODS: Thigh MRIs were acquired at baseline and 2-year follow-up for 20 young (16±1 years) and 20 mature (46±5 years) athletes (10 males, 10 females, respectively). Longitudinal changes in cross-sectional areas (CSAs) of femoral bone, quadriceps muscle, and thigh subcutaneous (SCF) and intermuscular (IMF) adipose tissue were evaluated...
2016: Journal of Musculoskeletal & Neuronal Interactions
M P Yavropoulou, J G Yovos
The skeleton has the ability to perfectly adapt to external forces of the operating environment, by altering its morphology and metabolism in order to meet different needs. This unique adaptive capacity of the skeleton creates an interesting range of biological questions concerning the perception of mechanical or other kinds of signals, the type of receptor, and the molecular pathways involved in this adaptation. Studies of the characteristics of the cellular engineering provide a host of new information that confers to osteocytes the role of the protagonist in the perception and regulation of mechanical effects on the skeleton...
2016: Journal of Musculoskeletal & Neuronal Interactions
A Benoit, T Mustafy, I Londono, G Grimard, C-E Aubin, I Villemure
Fusionless devices are currently designed to treat spinal deformities such as scoliosis by the application of a controlled mechanical loading. Growth modulation by dynamic compression was shown to preserve soft tissues. The objective of this in vivo study was to characterize the effect of static vs. dynamic loading on the bone formed during growth modulation. Controlled compression was applied during 15 days on the 7(th) caudal vertebra (Cd7) of rats during growth spurt. The load was sustained in the "static" group and sinusoidally oscillating in the "dynamic" group...
2016: Journal of Musculoskeletal & Neuronal Interactions
M T García-Gutiérrez, T J Hazell, P J Marín
OBJECTIVES: To evaluate the effects of whole-body vibration (WBV) on skeletal muscle activity and power performance of the upper body during decline bench press exercise at different loads. METHODS: Forty-seven healthy young and active male students volunteered. Each performed dynamic decline bench press repetitions with and without WBV (50 Hz, 2.2 mm) applied through a hamstring bridge exercise at three different loads of their 1-repetition maximum (1RM): 30%, 50%, and 70% 1RM...
2016: Journal of Musculoskeletal & Neuronal Interactions
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