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Clinics in Colon and Rectal Surgery

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https://www.readbyqxmd.com/read/29942217/uncommon-diverticular-disease
#1
REVIEW
Sanjay Mohanty, Shawn P Webb
This article describes the epidemiology, pathogenesis, diagnosis, and treatment of three rare variants of diverticular disease: cecal and right-sided colonic diverticula, giant colonic diverticula, and small bowel diverticula.
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942216/evaluation-of-quality-of-life-and-surgical-outcomes-for-treatment-of-diverticular-disease
#2
REVIEW
Mayin Lin, Shankar R Raman
The prevalence of diverticular disease in the Western and industrialized nations has increased over the last century, and our understanding of this disease and its management continues to evolve. In this article, we review the literature regarding the postoperative quality of life (QOL) and functional outcomes following surgical management of diverticulitis, including information regarding bowel function, recurrence of symptoms, and other postoperative sequelae. While objective parameters, such as attacks of diverticulitis, complications, and clinical episodes have been studied, there is a paucity of data on less objective factors, such as overall patient satisfaction after operative management of diverticular disease...
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942215/management-of-diverticular-bleeding-evaluation-stabilization-intervention-and-recurrence-of-bleeding-and-indications-for-resection-after-control-of-bleeding
#3
REVIEW
Mohammed Iyoob Mohammed Ilyas, Eric J Szilagy
Diverticular bleeding is the most common cause of lower gastrointestinal bleeding with nearly 200,000 admissions in the United States annually. Less than 5% of patients with diverticulosis present with diverticular bleeding and present usually as painless, intermittent, and large volume of lower gastrointestinal bleeding. Management algorithm for patients presenting with diverticular bleeding includes resuscitation followed by diagnostic evaluation. Colonoscopy is the recommended first-line investigation and helps in identifying the stigmata of recent hemorrhage and endoscopic management of the bleeding...
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942214/surgical-management-of-diverticular-disease-in-the-elective-setting
#4
REVIEW
Jeffrey A Neale
Diverticulosis is a common condition that has increased in prevalence in industrialized countries over the past century. Estimates of developing diverticular disease in the United states range from 5% by 40 years of age up, to over 80% by age 80. It is estimated that approximately 20% of patients with diverticulosis develop diverticulitis over the course of their lifetime. Diverticular disease can be divided into simple and chronic diverticulitis with various sub categories. There are various instances and circumstances where elective resection is indicated for both complex and simple forms of this disease process...
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942213/current-options-for-the-emergency-management-of-diverticular-disease-and-options-to-reduce-the-need-for-colostomy
#5
REVIEW
Dimitra Theodoropoulos
This article reviews the current options and recommendations for the emergency management of acute diverticulitis, including the spectrum of antibiotics, percutaneous drainage, laparoscopic lavage, and surgical options for resection with the restoration of bowel continuity.
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942212/management-of-diverticular-disease-in-the-setting-of-other-colorectal-pathology-data-on-simultaneous-issues-in-segmental-colitis-inflammatory-bowel-disease-cancer-and-complications
#6
REVIEW
Nasrin Ghalyaie
Diverticulosis of the colon is a very common anatomical condition. In the Western world, it affects more than 70% of over 65 years old population and represents the fifth most important gastrointestinal disease in terms of health care costs in Western countries. The diagnosis of diverticular disease and diverticulitis can be challenging. Often, there is overlap with other colonic pathologies, such as segmental colitis, ischemia, inflammatory bowel disease, cancer, or infectious colitis. Management of diverticular disease in these settings might be different...
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942211/considerations-and-changes-in-the-evaluation-management-and-outcomes-in-the-management-of-diverticular-disease-the-diagnosis-pathology-and-treatment-of-diverticular-colitis
#7
REVIEW
Robert J Kucejko, Juan L Poggio
Diverticular colitis, also known as segmental colitis associated with diverticulosis, is a colonic inflammatory disorder on the spectrum of inflammatory bowel disease (IBD). The disease consists of macroscopic and microscopic inflammation affecting inter-diverticular mucosa, sparing peri-diverticular mucosa, with inflammation confined to the descending and sigmoid colon. The disease likely arises from the altered immune response of an individual, genetically susceptible to the IBD spectrum of diseases. Patients with segmental colitis associated with diverticulosis (SCAD) are typically older, and likely represent a subgroup of IBD-susceptible patients who lacked an environmental trigger until that point in their life...
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942210/current-status-of-the-radiologic-assessment-of-diverticular-disease
#8
REVIEW
Pridvi G Kandagatla, Amalia J Stefanou
Radiologic assessment plays a vital role in the management of diverticulitis. It not only helps in the diagnosis, but also helps to guide the management. As technology has progressed, different modalities have offered insight into the treatment of this disease process. Through various trials and studies, certain modalities stand above the rest in terms of sensitivity and specificity. Computed tomography (CT) imaging has also proved to help us guide the management through a grading system. Newer studies show us the advantages of other modalities such as ultrasound and magnetic resonance imaging (MRI)...
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942209/medical-management-of-diverticular-disease
#9
REVIEW
Liam Knott, Craig A Reickert
This article reviews the current literature supporting the non-surgical options for treatment in acute uncomplicated diverticulitis, complicated diverticulitis, and options for prevention of recurrent diverticulitis.
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942208/epidemiology-and-pathophysiology-of-diverticular-disease
#10
REVIEW
Semeret T Munie, Surya P M Nalamati
Colonic diverticular disease is a common health care issue which has historically been attributed to western countries and older age population. Recent studies have shown a rise in incidence among developing countries that have adopted western diets as well as rise in prevalence among younger patients. In this article, the authors discuss the incidence, epidemiology, and pathophysiology of colonic diverticular disease.
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942207/diverticular-disease
#11
Craig A Reickert
No abstract text is available yet for this article.
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29942206/craig-a-reickert-md-facs-fascrs
#12
Scott R Steele
No abstract text is available yet for this article.
July 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720906/development-of-preclinical-models-to-understand-and-treat-colorectal-cancer
#13
REVIEW
Judith S Sebolt-Leopold
The establishment and validation of preclinical models that faithfully recapitulate the pathogenesis and treatment response of human colorectal cancer (CRC) is critical to expedient therapeutic advances in the clinical management of this disease. Integral to the application of precision medicine for patients diagnosed with metastatic CRC is the need to understand the molecular determinants of response for a given therapy. Preclinical models of CRC have proven invaluable in answering many of our basic questions relating to the molecular aberrations that drive colorectal tumor progression...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720905/the-role-of-the-gut-microbiome-in-colorectal-cancer
#14
REVIEW
Grace Y Chen
There is increasing evidence that the gut microbiome, which consists of trillions of microbes representing over 1,000 species of bacteria with over 3 million genes, significantly impacts intestinal health and disease. The gut microbiota not only is capable of promoting intestinal homeostasis and antitumor responses but can also contribute to chronic dysregulated inflammation as well as have genotoxic effects that lead to carcinogenesis. Whether the gut microbiota maintains health or promotes colon cancer may ultimately depend on the composition of the gut microbiome and the balance within the microbial community of protective and detrimental bacterial populations...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720904/emerging-systemic-therapies-for-colorectal-cancer
#15
REVIEW
Christine M Veenstra, John C Krauss
Despite advances over the past 20 years in colorectal cancer (CRC) screening, diagnosis, and treatment, survival outcomes remain suboptimal. Five-year survival for patients with locally advanced CRC is 69%; 5-year survival drops to 12% for patients with metastatic disease. Novel, effective systemic therapies are needed to improve long-term outcomes. In this review, we describe currently available systemic therapies for the treatment of locally advanced and metastatic CRC and discuss emerging therapies, including encouraging advances in identifying novel targeted agents and exciting responses to immunotherapeutic agents...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720903/colorectal-cancer-in-inflammatory-bowel-disease
#16
REVIEW
Ryan W Stidham, Peter D R Higgins
Patients with inflammatory bowel disease (IBD) are at significantly increased risk of colorectal cancer (CRC), principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Epidemiologic studies continue to highlight the increased risk of CRC in IBD. However, the incidence has declined over the past 30 years, attributed to both successful CRC-surveillance programs and improved control of mucosal inflammation. Risk factors that further increase the risk of IBD-related CRC include disease duration, extent and severity, the presence of inflammatory pseudopolyps, coexistent primary sclerosing cholangitis, and a family history of CRC...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720902/translational-research-in-familial-colorectal-cancer-syndromes
#17
REVIEW
Molly M Ford
Growing knowledge of inherited colorectal cancer syndromes has led to better surveillance and better care of this subset of patients. The most well-known entities, including Lynch syndrome and familial adenomatous polyposis, are continually being studied and with the advent of more sophisticated genetic testing, additional genetic discoveries have been made in the field of inherited cancer. This article will summarize many of the updates to both the familiar and perhaps less familiar syndromes that can lead to inherited or early-onset colorectal cancer...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720901/updates-on-translational-research-on-prevention-of-polyps-and-colorectal-cancer
#18
REVIEW
Elena M Stoffel
Morbidity and mortality from colorectal cancer (CRC) can be effectively reduced through early detection and prevention. To date, strategies for managing CRC risk have focused primarily on secondary prevention, through screening asymptomatic individuals for colorectal neoplasia. In the United States, implementation of screening among individuals age ≥50 has led to not only decreased CRC-related mortality but also reduced CRC incidence through colonoscopic removal of precancerous polyps. In contrast to screening's endpoint of early detection, the goal of primary prevention of CRC is to arrest and/or reverse colorectal carcinogenesis...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720900/update-on-sporadic-colorectal-cancer-genetics
#19
REVIEW
Karin M Hardiman
Our understanding of the genetics of colorectal cancer has changed dramatically over recent years. Colorectal cancer can be classified in multiple different ways. Along with the advent of whole-exome sequencing, we have gained an understanding of the scale of the genetic changes found in sporadic colorectal cancer. We now know that there are multiple pathways that are commonly involved in the evolution of colorectal cancer including Wnt/β-catenin, RAS, EGFR, and PIK3 kinase. Another recent leap in our understanding of colorectal cancer genetics is the recognition that many, if not all tumors, are actually genetically heterogeneous within individual tumors and also between tumors...
May 2018: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29720899/translational-research-in-colorectal-cancer
#20
Karin M Hardiman
No abstract text is available yet for this article.
May 2018: Clinics in Colon and Rectal Surgery
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