journal
https://read.qxmd.com/read/38301855/trypanosomatid-diversity-in-a-bat-community-of-an-urban-area-in-campo-grande-mato-grosso-do-sul-brazil
#21
JOURNAL ARTICLE
Jaire Marinho Torres, Carina Elisei de Oliveira, Filipe Martins Santos, Nayara Yoshie Sano, Érica Verneque Martinez, Fernanda Moreira Alves, Luiz Eduardo Roland Tavares, André Luiz Rodrigues Roque, Ana Maria Jansen, Heitor Miraglia Herrera
Bats have a long evolutionary history with trypanosomatids, but the role of these flying mammals on parasite transmission cycles in urban areas, especially for Trypanosoma and Leishmania species, remains poorly known. The objective of this study was to evaluate the species richness of trypanosomatids parasitizing a bat community in Campo Grande (CG), a state capital within the Cerrado of the Brazilian Midwest. We evaluated 237 bats of 13 species by means of hemoculture and molecular detection in spleen samples...
January 30, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38280473/genome-analysis-deciphered-chryseobacterium-indicum-is-a-distinct-species-associated-with-freshwater-pufferfish
#22
JOURNAL ARTICLE
Manish Prakash Victor, Ritu Rani Archana Kujur, Lipika Das, Subrata K Das
A bacterium, strain PS-8T of the genus Chryseobacterium, was isolated from the skin of freshwater pufferfish (Tetraodon cutcutia). Strain PS-8T is a Gram-negative, aerobic, non-motile, and rod-shaped bacterium. Colonies appear in yellowish-orange colors. The major cellular fatty acids were C15:0 iso, C17:0 iso 3OH, C15:0 iso 3OH, and C11:0 anteiso. The predominant polar lipids were phosphatidylethanolamine and amino lipids. The genome size is 4.83 Mb. The G + C content was 35.6%. The in silico dDDH homology, ANI, and AAI were below the cutoff value, 70% and 95% to 96%, respectively, suggesting that strain PS-8T represents a defined species...
January 25, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38266757/consanguineous-marriages-increase-the-incidence-of-recurrent-tuberculosis-evidence-from-whole-exome-sequencing
#23
JOURNAL ARTICLE
Noor Ul Akbar, Sajjad Ahmad, Taj Ali Khan, Muhammad Tayyeb, Naheed Akhter, Laraib Shafiq, Shahid Niaz Khan, Mohammad Mahtab Alam, Alduwish Manal Abdullah, Muhammad Fayyaz Ur Rehman, Majed A Bajaber, Muhammad Safwan Akram
BACKGROUND: In this study, we have identified multiple mutations in the IL-12R1 gene among Pakistani patients who have inherited them through consanguineous marriages. These patients have experienced severe Bacille-Calmette-Guérin (BCG) infection as well as recurrent tuberculosis. We will demonstrate the pivotal role of interleukin (IL)-12/interferon (IFN)-γ axis in the regulation of mycobacterial diseases. METHODOLOGY: First, we checked the patients' medical records, and then afterward, we assessed interferon-gamma (IFN-γ) production through ELISA...
January 22, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38262571/serological-and-molecular-epidemiological-investigation-of-mediterranean-spotted-fever-in-yunnan-province-china
#24
JOURNAL ARTICLE
Suyi Luo, Shuyue Yang, Aihua Liu, Hanxin Wu, Li Gao, Xinya Wu, Yan Dong, Bingxue Li, Weijiang Ma, Li Peng, Fukai Bao
OBJECTIVES: Given the limited research and its potential hazards, the study aimed to determine the prevalence of Mediterranean spotted fever (MSF) caused by Rickettsia conorii (R. conorii), a tick-borne disease, in Yunnan Province, China. METHODS: Through stratified sampling across five distinct regions in Yunnan, 5358 blood samples were obtained from the general healthy population. Enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence assay (IFA), and Polymerase chain reaction (PCR) were employed for analysis...
January 21, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38246398/phylogenetic-congruence-of-plasmodium-spp-and-wild-ungulate-hosts-in-the-peruvian-amazon
#25
JOURNAL ARTICLE
Gabriela M Ulloa, Alex D Greenwood, Omar E Cornejo, Frederico Ozanan Barros Monteiro, Alessandra Scofield, Meddly L Santolalla Robles, Andres G Lescano, Pedro Mayor
Malaria parasites are known to infect a variety of vertebrate hosts, including ungulates. However, ungulates of Amazonia have not been investigated. We report for the first time, the presence of parasite lineages closely related to Plasmodium odocoilei clade 1 and clade 2 in free-ranging South American red-brocket deer (Mazama americana; 44.4%, 4/9) and gray-brocket deer (Mazama nemorivaga; 50.0%, 1/2). We performed PCR-based analysis of blood samples from 47 ungulates of five different species collected during subsistence hunting by an indigenous community in the Peruvian Amazon...
January 19, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38244749/genetic-polymorphisms-of-plasmodium-vivax-ookinete-sexual-stage-surface-proteins-pvs25-and-pvs28-from-thailand
#26
JOURNAL ARTICLE
Jiraporn Kuesap, Nutnicha Suphakhonchuwong, Kanchana Rungsihirunrat
Plasmodium vivax is the most geographically widespread malaria parasite in human presently. The ookinete surface proteins of sexual stage of malaria parasites, Pvs25 and Pvs28, are candidates for the transmission blocking vaccine. The antigenic variation in population might be barrier for vaccine development. The objective of this study was to investigate the genetic diversity of Pvs25 and Pvs28 in endemic areas of Thailand. P. vivax clinical isolates collected from Thai-neighboring border areas were analyzed using polymerase chain reaction and sequencing method...
January 18, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38244748/molecular-epidemiology-and-phylogeny-of-the-emerging-zoonotic-virus-rocahepevirus-a-global-genetic-analysis
#27
JOURNAL ARTICLE
Han Wu, Lu Zhou, Fengge Wang, Zixiang Chen, Yihan Lu
Human infections with Rocahepevirus ratti genotype C1 (HEV-C1) in Hong Kong of China, Canada, Spain, and France have drawn worldwide concern towards Rocahepevirus. This study conducted a global genetic analysis of Rocahepevirus, aiming to furnish comprehensive molecular insights and promote further research. We retrieved 817 Rocahepevirus sequences from the GenBank database through October 31, 2023, categorizing them according to research, sample collection area and date, genotype, host, and sequence length...
January 18, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38242186/understanding-sars-cov-2-spike-glycoprotein-clusters-and-their-impact-on-immunity-of-the-population-from-rio-grande-do-norte-brazil
#28
JOURNAL ARTICLE
Diego Gomes Teixeira, João Firmino Rodrigues-Neto, Dayse Caroline Severiano da Cunha, Selma Maria Bezerra Jeronimo
SARS-CoV-2 genome underwent mutations since it started circulating within the human population. The aim of this study was to understand the fluctuation of the spike clusters concomitant to the population immunity either due to natural infection and/or vaccination in a state of Brazil that had both high rate of natural infection and vaccination coverage. A total of 1725 SARS-CoV-2 sequences from the state of Rio Grande do Norte, Brazil, were retrieved from GISAID and subjected to cluster analysis. Immunoinformatics were used to predict T- and B-cell epitopes, followed by simulation to estimate either pro- or anti-inflammatory responses and to correlate with circulating variants...
January 17, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38242185/genetic-characteristics-of-a-novel-hiv-1-circulating-recombinant-form-crf128_07b-identified-among-msm-in-guangdong-province-china
#29
JOURNAL ARTICLE
Yun Lan, Ruolei Xin, Xizi Deng, Feng Li, Xuemei Ling, Kun Zeng, Chuyu Zhang, Linghua Li, Fengyu Hu
OBJECTIVE: To obtain and investigate the genetic characteristics of four HIV-1 near full-length genome sequences (NFLGs), aiming at a description of a novel circulating recombinant form (CRF) in Guangdong China. METHODS: Plasma samples were collected from HIV-1 infected MSM patients in Guangdong Province who had no epidemiological association with each other. The NFLGs were amplified with two overlapping halves and phylogenetic analyses were performed using Mega V11...
January 17, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38228216/gene-polymorphisms-of-il-17a-and-bacterial-meningitis-in-angolan-children
#30
JOURNAL ARTICLE
Johanna Teräsjärvi, Elina Tenhu, Manuel Leite Cruzeiro, Okko Savonius, Emilie Rugemalira, Qiushui He, Tuula Pelkonen
Interleukin (IL)-17 A plays a crucial role in protecting hosts from invading bacterial pathogens. In this study, we investigated if single nucleotide polymorphisms (SNPs) in IL-17A are associated with susceptibility and outcome of bacterial meningitis (BM) in Angolan children. The study sample comprised 241 confirmed BM patients and 265 controls, which were matched for age and ethnicity. Three IL-17A SNPs - rs2275913 (-197G > A), rs8193036 (-737C > T) and rs4711998 (-877 A > G) - were determined by high-resolution melting analysis (HRMA)...
January 14, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38218390/in-vivo-biological-validation-of-in-silico-analysis-a-novel-approach-for-predicting-the-effects-of-tlr4-exon-3-polymorphisms-on-brucellosis
#31
JOURNAL ARTICLE
Antonio Gentile, Andrea Fulgione, Barbara Auzino, Valentina Iovane, Daniela Gallo, Raffaele Garramone, Nunzia Iaccarino, Antonio Randazzo, Giuseppe Iovane, Paola Cuomo, Rosanna Capparelli, Domenico Iannelli
The role of the Toll like receptor 4 (TLR4) is of recognising intracellular and extracellular pathogens and of activating the immune response. This process can be compromised by single nucleotide polymorphisms (SNPs) which might affect the activity of several TLRs. The aim of this study is of ascertaining whether SNPs in the TLR4 of Bubalus bubalis infected by Brucella abortus, compromise the protein functionality. For this purpose, a computational analysis was performed. Next, computational predictions were confirmed by performing genotyping analysis...
January 11, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38216107/metagenomic-analysis-of-the-ocular-toxoplasmosis-in-children-uveitis-from-fayoum-governorate-egypt
#32
JOURNAL ARTICLE
Marwa A Elmallawany, Amany A Ldelkl, Khaled G Lu Eleinen, Ahmed H Nadar, Azza I El-Adawy, Marwa A El-Dardiry, Yosra N Ldel-Hafez, Ahmed A Kotb, Ahmed T S Saif, Hoda A A Shaheen, Ahmed Sayed, Omar Samir, Adham A Alatyar, Mostafa A Sheble, Mostafa Elnakib, Mohamed S Badr, Reham K Nahnoush
Granulomatous anterior uveitis with single or numerous gelatinous nodules was found in children living in rural Egypt. All ocular diseases were originally thought to be water-born and related to digenic flukes. The current study sought to learn more about the causes of anterior granulomatous uveitis in Egyptian youngsters who used to swim in rural water canals. 50 children with eye lesions that had not responded to medical treatment were recruited. Four samples were surgically extracted and examined using real-time PCR, transmission electron microscopy (TEM), and shotgun metagenomic sequencing (SMS)...
January 10, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38216106/evolutionary-analysis-of-major-histocompatibility-complex-variants-in-chytrid-resistant-and-susceptible-amphibians
#33
JOURNAL ARTICLE
Minjie Fu
An emerging infectious disease (EID) affecting amphibians, caused by Batrachochytrium dendrobatidis (Bd), originated in Asia but primarily led to declines and extinctions in amphibian populations outside of Asia. Host major histocompatibility complex (MHC) molecules exhibit high polymorphic, and the evolution of MHC can be influenced by recombination and pathogens. Previous studies have indicated that MHC class II may undergo selection for Bd adaptation. In this study, I conducted recombination and selection tests on functional MHC IIß1 alleles from an Asian Bd-resistant anuran species (Bufo gargarizans) and an Australasian Bd-susceptible species (Litoria caerulea)...
January 10, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38199505/direct-detection-of-canine-picornavirus-complete-coding-sequence-in-wastewater-using-long-range-reverse-transcriptase-polymerase-chain-reaction-and-long-read-sequencing
#34
JOURNAL ARTICLE
Temitope O C Faleye, Erin M Driver, Jillian M Wright, Rolf U Halden, Arvind Varsani, Matthew Scotch
We describe four complete coding sequence (cCDS) of canine picornavirus from wastewater in Arizona, USA detected by coupling cCDS single-contig (~7.5 kb) reverse-transcriptase polymerase chain reaction (RT-PCR) and low-cost long-read high-throughput sequencing. For viruses of medical/veterinary importance, this workflow expands possibilities of wastewater based genomic epidemiology for exploring virus evolutionary dynamics especially in low-resource settings.
January 8, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38181886/comparative-genomics-and-characterization-of-a-multidrug-resistant-acinetobacter-baumannii-vrl-m19-isolated-from-a-crowded-setting-in-india
#35
JOURNAL ARTICLE
Neha Verma, Tina Sharma, Anshu Bhardwaj, Vemuluri Venkata Ramana
A crowded vegetable market serves as a mass gathering, posing a potential risk for infection transmission. In this study, we isolated a multidrug-resistant Acinetobacter baumannii strain, VRL-M19, from the air of such a market and conducted comparative genomics and phenotypic characterization. Antimicrobial susceptibility testing, genome sequencing using Illumina HiSeq X10, and pan-genome analysis with 788 clinical isolates identified core, accessory, and unique drug-resistant determinants. Mutational analysis of drug-resistance genes, virulence factor annotation, in vitro pathogenicity assessment, subsystem analysis, Multilocus sequence typing, and whole genome phylogenetic analysis were performed...
January 3, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38176604/detection-of-circovirus-in-free-ranging-brown-rats-rattus-norvegicus
#36
JOURNAL ARTICLE
Z L Tarján, S Szekeres, M Z Vidovszky, L Egyed
Accidentally found, two poisoned brown rats from Hungary were surveyed for presence of circoviral DNA, using specific nested primers, designed against the rep gene of the virus. Both specimens were positive. The whole genomes were amplified using inverse PCR based on the Rep sequence parts and sequenced by the primer walking method. Genomic analyses revealed that these novel rat viruses, together with tawny owl-associated circovirus reported by Italian researchers in 2022, are sequence variations of the same virus from genus Circovirus...
January 2, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38159712/microsatellite-markers-for-genotyping-of-kodamaea-ohmeri-demonstrating-outbreaks-based-on-a-multicenter-surveillance-study-in-china
#37
JOURNAL ARTICLE
Yanbing Li, Yuyan Huang, Mei Kang, Xiangyang Chen, Liwen Liu, Hongmei Zhao, Zhongju Chen, Meng Xiao, Yingchun Xu, Qiaolian Yi, Menglan Zhou
Kodamaea ohmeri, an emerging human pathogen, caused both sporadic and nosocomial infections among immunocompromised people with high mortality. However, there is limited research on the molecular epidemiology of K. ohmeri. A total of fifty microsatellite loci were designed based on K. ohmeri type strain NRRL Y-1932 and three loci were finally selected for microsatellite analysis. Non-duplicated K. ohmeri isolates and strains of other species were collected across China as a part of CHIF-NET program for sensitivity and specificity verification...
December 28, 2023: Infection, Genetics and Evolution
https://read.qxmd.com/read/38176603/characteristics-of-cervical-cancer-caused-by-the-human-papillomavirus-18-and-its-genetic-variations-in-vietnamese-women
#38
JOURNAL ARTICLE
Than Manh Hung, Hoang Xuan Son, Le Van Nguyen Bang, Le Van Duyet
BACKGROUND: The involvement of HPV18 in cervical cancer pathogenesis, as well as its high oncogenic potential and influence on the variation of cervical cancer distribution in different geographical regions, makes assessing the characteristics of cervical cancer and its variants the basis for considering potential carcinogenic HPV18 sequence variations and vaccine strategies. METHODS: A prospective study was conducted at Vietnam Central Obstetrics Hospital from January 1, 2019 to December 31, 2020...
January 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38160879/biofilms-a-developmental-niche-for-vancomycin-intermediate-staphylococcus-aureus
#39
JOURNAL ARTICLE
Jenelle E Chapman, Shilpa E George, Christiane Wolz, Michael E Olson
Staphylococcus aureus are gram-positive bacteria responsible for a wide array of diseases, ranging from skin and soft tissue infections to more chronic illnesses such as toxic shock syndrome, osteomyelitis, and endocarditis. Vancomycin is currently one of the most effective antibiotics available in treating patients infected with methicillin-resistant S. aureus (MRSA), however the emergence of vancomycin-resistant S. aureus (VRSA), and more commonly vancomycin-intermediate S. aureus (VISA), threaten the future efficacy of vancomycin...
January 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38135265/high-prevalence-of-enterovirus-e-bovine-kobuvirus-and-astrovirus-revealed-by-viral-metagenomics-in-fecal-samples-from-cattle-in-central-colombia
#40
JOURNAL ARTICLE
Julián Esteban Medina, Sergio Castañeda, Luisa Páez-Triana, Milena Camargo, Diego J Garcia-Corredor, Marcela Gómez, Nicolas Luna, Angie L Ramírez, Martín Pulido-Medellín, Marina Muñoz, Juan David Ramírez
Livestock plays a crucial role in ensuring food security and driving the global economy. However, viral infections can have far-reaching consequences beyond economic productivity, affecting the health of cattle, as well as posing risks to human health and other animals. Identifying viruses present in fecal samples, a primary route of pathogen transmission, is essential for developing effective prevention, control, and surveillance strategies. Viral metagenomic approaches offer a broader perspective and hold great potential for detecting previously unknown viruses or uncovering previously undescribed agents...
December 20, 2023: Infection, Genetics and Evolution
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