Kazunari Yoshida, Victoria S Marshe, Samar S M Elsheikh, Malgorzata Maciukiewicz, Arun K Tiwari, Eva J Brandl, Jeffrey A Lieberman, Herbert Y Meltzer, James L Kennedy, Daniel J Müller
Given the polygenic nature of antipsychotic-induced weight gain (AIWG), we investigated whether polygenic risk scores (PRS) for various psychiatric and metabolic traits were associated with AIWG. We included individuals with schizophrenia (SCZ) of European ancestry from two cohorts (N = 151, age = 40.3 ± 11.8 and N = 138, age = 36.5 ± 10.8). We investigated associations of AIWG defined as binary and continuous variables with PRS calculated from genome-wide association studies of body mass index (BMI), coronary artery disease (CAD), fasting glucose, fasting insulin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, type 1 and 2 diabetes mellitus, and SCZ, using regression models...
April 27, 2023: Pharmacogenomics Journal