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Journals Journal of Cellular and Molecu...

Journal of Cellular and Molecular Medicine

https://read.qxmd.com/read/38400579/calotropis-procera-extract-inhibits-prostate-cancer-through-regulation-of-autophagy
#1
JOURNAL ARTICLE
Palak Singh, Bodhana Dhole, Jaganmoy Choudhury, Anannya Tuli, Deepak Pandey, Thirumurthy Velpandian, Surabhi Gupta, Pradeep Kumar Chaturvedi
Current treatment options available for prostate cancer (PCa) patients have many adverse side effects and hence, new alternative therapies need to be explored. Anticancer potential of various phytochemicals derived from Calotropis procera has been studied in many cancers but no study has investigated the effect of leaf extract of C. procera on PCa cells. Hence, we investigated the effect of C. procera leaf extract (CPE) on cellular properties of androgen-independent PC-3 and androgen-sensitive 22Rv1 cells. A hydroalcoholic extract of C...
February 23, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38393307/integrated-analysis-of-single-cell-rna-seq-and-bulk-rna-seq-unravels-the-molecular-feature-of-m2-macrophages-of-head-and-neck-squamous-cell-carcinoma
#2
JOURNAL ARTICLE
Siyuan Wu, Xiaozhi Lv, Haigang Wei, Jialin Wu, Shiwei Liu, Xia Li, Jing Song, Chen Zou, Yilong Ai
The connection between head and neck squamous cell carcinoma (HNSC) and M2 tumour-associated macrophages is not yet fully understood. We gathered gene expression profiles and clinical data from HNSC patients in the TCGA database. Using Consensus Clustering, we categorized these patients into M2 macrophage-related clusters. We developed a M2 macrophage-related signature (MRS) through statistical analyses. Additionally, we assessed gene expression in HNSC cells using single-cell sequencing data (GSE139324). We identified three distinct M2 macrophage-related clusters in HNSC, each with different prognostic outcomes and immune characteristics...
February 23, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38386354/plasminogen-activator-inhibitor-1-serum-levels-in-frontotemporal-lobar-degeneration
#3
JOURNAL ARTICLE
Francesco Angelucci, Katerina Veverova, Alžbeta Katonová, Martin Vyhnalek, Jakub Hort
Plasminogen activator inhibitor-1 (PAI-1) impedes brain plasmin synthesis. Reduced plasmin activity facilitates cumulation of amyloid beta (Aβ) in Alzheimer's disease (AD). Since plasmin also regulates the synaptic activity, it is possible that altered PAI-1 is present in other neurodegenerative disorders. We investigated whether PAI-1 and its counter-regulatory tissue plasminogen activator (tPA) are altered in serum of patients with dementia due to frontotemporal lobar degeneration (FTLD). Thirty five FTLD patients (21 in mild cognitive impairment stage (MCI) and 14 in dementia stage) and 10 cognitively healthy controls were recruited...
February 22, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38303549/endoplasmic-reticulum-stress-regulators-exhibit-different-prognostic-therapeutic-and-immune-landscapes-in-pancreatic-adenocarcinoma
#4
JOURNAL ARTICLE
Shanshan Liu, Kaini He, Longbao Yang, Fangshi Xu, Xiaoguang Cui, Li Qu, Xueyi Li, Bin-Cheng Ren
Endoplasmic reticulum stress (ERS) and unfolded protein response are the critical processes of tumour biology. However, the roles of ERS regulatory genes in pancreatic adenocarcinoma (PAAD) remain elusive. A novel ERS-related risk signature was constructed using the Lasso regression analysis. Its prognostic value, immune effect, metabolic influence, mutational feature and therapeutic correlation were comprehensively analysed through multiple bioinformatic approaches. The biofunctions of KDELR3 and YWHAZ in pancreatic cancer (PC) cells were also investigated through colony formation, Transwell assays, flow cytometric detection and a xenograft model...
February 1, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38279519/unravelling-the-heterogeneity-of-oral-squamous-cell-carcinoma-by-integrative-analysis-of-single-cell-and-bulk-transcriptome-data
#5
JOURNAL ARTICLE
Jia Li, Shengjiao Li, Mingyang Shu, Weiwei Hu
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy of the head and neck with rising global incidence. Despite advances in treatment modalities, OSCC prognosis remains diverse due to the complex molecular and cellular heterogeneity within tumours, as well as the heterogeneity in tumour microenvironment (TME). In this study, we utilized single-cell RNA sequencing (scRNA-seq) analysis to explore distinct subpopulations of tumour cells in OSCC tissues and their interaction with components in TME. We identified four major tumour cell subpopulations (C0, C1, C2 and C3) with unique molecular characteristics and functional features...
January 26, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38263865/mettl14-mir-29c-3p-axis-drives-aerobic-glycolysis-to-promote-triple-negative-breast-cancer-progression-though-trim9-mediated-pkm2-ubiquitination
#6
JOURNAL ARTICLE
Hao Wu, Yile Jiao, Xinyi Guo, Zhenru Wu, Qing Lv
The energy metabolic rearrangement of triple-negative breast cancer (TNBC) from oxidative phosphorylation to aerobic glycolysis is a significant biological feature and can promote the malignant progression. However, there is little knowledge about the functional mechanisms of methyltransferase-like protein 14 (METTL14) mediated contributes to TNBC malignant progression. Our study found that METTL14 expression was significantly upregulated in TNBC tissues and cell lines. Silencing METTL14 significantly inhibited TNBC cell growth and invasion in vitro, as well as suppressed tumour growth...
January 23, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38260950/the-whole-is-greater-than-the-sum-of-its-parts-long-read-sequencing-for-solving-clinical-problems-in-haematology
#7
JOURNAL ARTICLE
Carlos Bravo-Perez, Rosa Cifuentes-Riquelme, Jose Padilla, Maria E de la Morena-Barrio, Francisco J Ortuño, Pedro Garrido-Rodríguez, Maria L Amigo, Inmaculada Heras, Vicente Vicente, Maria L Lozano, Raul Teruel-Montoya, Belen de la Morena-Barrio, Javier Corral
No abstract text is available yet for this article.
January 23, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38239038/linc00707-impairs-the-natural-killer-cell-antitumour-activity-in-hepatocellular-carcinoma-through-decreasing-ythdf2-stability
#8
JOURNAL ARTICLE
Mingwei Wei, Libai Lu, Jiasheng Ma, Zongjiang Luo, Xijuan Tan, Jianchu Wang
Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer and ranks third in cancer-related fatalities. The recognized involvement of long noncoding RNAs (lncRNAs) in several cancer types, including HCC, inspired this study to explore a novel lncRNA's functional importance in the progression of HCC. To achieve this, lncRNA microarray analysis was conducted on three distinct sets of HCC tissues, revealing LINC00707 as the most significantly upregulated lncRNA. Further research into its biological functions has revealed that LINC00707 acts as an oncogene, driving HCC progression by enhancing the proliferation, migration and invasion of HCC cells...
January 18, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38235996/low-expression-of-tgf-%C3%AE-2-and-matrilin2-in-human-aqueous-humour-with-acute-primary-angle-closure
#9
JOURNAL ARTICLE
Liming Wang, Zhao Xu, Yaru Hong, Yan Liu, Xiaomin Zhang, Qiang Feng, Dandan Zhang, Kexi Chen, Guli Humaer Yiming, Xiaorong Li, Aihua Liu, Lijie Dong
Primary angle-closure glaucoma (PACG) is the leading cause of irreversible blindness in the world. Angle closure induced by pupil block and secondary iris synechia is the fundamental pathology of the PACG. The molecular mechanisms of angle closure have not yet been clearly illustrated. This study was designed to investigate the protein difference in the aqueous humour and explore new biomarker of the PACG. Aqueous humour (AH) was collected from patients with acute primary angle closure (APAC) and cataract (n = 10 in APAC group) and patients with cataract only (n = 10 in control group)...
January 18, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38235989/sex-specific-differences-in-telomere-length-of-patients-with-primary-knee-osteoarthritis
#10
JOURNAL ARTICLE
Lukasz Kuszel, Tomasz Trzeciak, Beata Begier-Krasinska, Magdalena Richter, Jian Li, Malwina Czarny-Ratajczak
Accelerated telomere shortening is associated with age-related diseases, including osteoarthritis (OA). We aimed to determine the relative telomere length (TL) in leukocytes and cartilage of patients with primary knee OA and to investigate factors that may affect TL in OA. Relative TL measurements were performed using qPCR in leukocytes of 612 individuals (310 patients with primary knee OA undergoing total knee arthroplasty (TKA) and 302 unaffected controls). We also analysed cartilage in 57 of the 310 OA patients, measuring relative TL in severely affected and less affected (control) cartilage collected from the same knee...
January 18, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38229475/usp11-promotes-glycolysis-by-regulating-hif-1%C3%AE-stability-in-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Lijun Qiao, Weibin Hu, Linzhi Li, Xin Chen, Liping Liu, Jingbo Wang
Understanding the mechanisms underlying metastasis in hepatocellular carcinoma (HCC) is crucial for developing new therapies against this fatal disease. Deubiquitinase ubiquitin-specific protease 11 (USP11) belongs to the deubiquitinating family and has previously been reported to play a critical role in cancer pathogenesis. Although it has been established that USP11 can facilitate the metastasis and proliferation ability of HCC, the underlying regulatory mechanisms are poorly understood. The primary objective of this research was to reveal hitherto undocumented functions of USP11 during HCC progression, especially those related to metabolism...
January 16, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38217314/epitope-screening-and-vaccine-molecule-design-of-prrsv-gp3-and-gp5-protein-based-on-immunoinformatics
#12
JOURNAL ARTICLE
Dongyu Liu, Yaping Chen
Porcine reproductive and respiratory syndrome (PRRS) is a respiratory disease in pigs that causes severe economic losses. Currently, live PRRSV vaccines are commonly used but fail to prevent PRRS outbreaks and reinfection. Inactivated PRRSV vaccines have poor immunogenicity, making PRRSV a significant threat to swine health globally. Therefore, there is an urgent need to develop an effective PRRSV vaccine. This study used immunoinformatics to predict, screen, design and construct a candidate vaccine that fused B-cell epitopes, CTL- and HTL-dominant protective epitopes of PRRSV strain's GP3 and GP5 proteins...
January 12, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38214430/eebr-induces-caspase-1-dependent-pyroptosis-through-the-nf-%C3%AE%C2%BAb-nlrp3-signalling-cascade-in-non-small-cell-lung-cancer
#13
JOURNAL ARTICLE
Xin Zhao, Chao Chen, Weina Han, Min Liang, Yuanyuan Cheng, Yingjie Chen, Defeng Pang, Haoqi Lei, Xuefei Feng, Shifeng Cao, Zhixiong Li, Jinhui Wang, Yan Zhang, Baofeng Yang
Lung cancer is a leading cause of cancer-related deaths worldwide. Recent studies have identified pyroptosis, a type of programmed cell death, as a critical process in the development and progression of lung cancer. In this study, we investigated the effect of EEBR, a new compound synthesized by our team, on pyroptosis in non-small cell lung cancer cells (NSCLC) and the underlying molecular mechanisms. Our results demonstrated that EEBR significantly reduced the proliferation and metastasis of NSCLC cells in vitro...
January 12, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38214394/nrf2-ho-1-nf-%C3%AE%C2%BAb-and-pi3k-akt-signalling-pathways-decipher-the-therapeutic-mechanism-of-pitavastatin-in-early-phase-liver-fibrosis-in-rats
#14
JOURNAL ARTICLE
Marawan A Elbaset, Bassim M S A Mohamed, Alyaa Hessin, Sahar S Abd El-Rahman, Tuba Esatbeyoglu, Sherif M Afifi, Hany M Fayed
Liver fibrosis is a common chronic hepatic disease. This study aimed to investigate the effect of pitavastatin (Pit) against thioacetamide (TAA)-induced liver fibrosis. Rats were divided into four groups: (1) control group; (2) TAA group (100 mg/kg, i.p.) three times weekly for 2 weeks; (3 and 4) TAA/Pit-treated group, in which Pit was administered orally (0.4 and 0.8 mg/kg/day) for 2 weeks following TAA injections. TAA caused liver damage manifested by elevated serum transaminases, reduced albumin and histological alterations...
January 12, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38213100/c-x-c-chemokine-receptor-type-4-promotes-tubular-cell-senescence-and-renal-fibrosis-through-%C3%AE-catenin-inhibited-fatty-acid-oxidation
#15
JOURNAL ARTICLE
Qinyu Wu, Qiurong Chen, Dan Xu, Xiaoxu Wang, Huiyun Ye, Xiaolong Li, Yabing Xiong, Jiemei Li, Shan Zhou, Jinhua Miao, Weiwei Shen, Youhua Liu, Hongxin Niu, Ying Tang, Lili Zhou
The prevalence of chronic kidney disease (CKD) is highly increasing. Renal fibrosis is a common pathological feature in various CKD. Previous studies showed tubular cell senescence is highly involved in the pathogenesis of renal fibrosis. However, the inducers of tubular senescence and the underlying mechanisms have not been fully investigated. C-X-C motif chemokine receptor 4 (CXCR4), a G-protein-coupled seven-span transmembrane receptor, increases renal fibrosis and plays an important role in tubular cell injury...
January 11, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38193829/long-non-coding-rna-as-a-potential-diagnostic-and-prognostic-biomarker-in-melanoma-a-systematic-review-and-meta-analysis
#16
REVIEW
Mahdi Masrour, Shaghayegh Khanmohammadi, Parisa Fallahtafti, Seyedeh Melika Hashemi, Nima Rezaei
Recently, long noncoding RNAs (lncRNAs) have been applied as biomarkers for melanoma patients. In this systematic review and meta-analysis, we investigated the diagnostic and prognostic value of lncRNAs. We used the keywords 'lncRNA' and 'melanoma' to search databases for studies published before June 14th, 2023. The specificity, sensitivity and AUC were utilized to assess diagnostic accuracy and the prognostic value was assessed using overall survival, progression-free survival and disease-free survival hazard ratios...
January 9, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38189641/polymorphism-of-il-12-il-23-axis-is-associated-with-coronary-heart-disease
#17
JOURNAL ARTICLE
Jiangtao Dong, Qianwen Chen, Tian Xie, Mengru Wang, Mengqi Wang, Lingfeng Zha
IL12B encodes the shared p40 subunit (IL-12p40) of IL-12 and IL-23, which have diverse immune functions and are closely related to the occurrence and development of atherosclerosis (AS). However, the exact role of IL12B in coronary heart disease (CHD) was still unknown. A case-control association analysis was performed between five single nucleotide polymorphisms (SNPs) of IL12B (rs1003199, rs3212219, rs2569254, rs2853694 and rs3212227) and CHD in Chinese Han population (1824 patients with CHD vs. 2784 controls)...
January 8, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38186203/mir-664a-5p-promotes-experimental-membranous-nephropathy-progression-through-hipk2-calpain1-gs%C3%AE-mediated-autophagy-inhibition
#18
JOURNAL ARTICLE
Zhiming Shan, Zhenchao Zhuang, Peiyao Ren, Li Zhao, Danna Zheng, Wei Chen, Juan Jin
We previously found that miR-664a-5p is specifically expressed in urinary exosomes of idiopathic membranous nephropathy (IMN) patients. Homeodomain-interacting protein kinase 2 (HIPK2), a nuclear serine/threonine kinase, plays an important role in nephropathy. But the function of these factors and their connection in MN are unclear. To investigate the function and mechanism of miR-664a-5p in MN, the miR-664a-5p expression in HK-2 cells, exosomes, podocytes and renal tissues were studied, as well as cell growth and apoptosis of these cells, the binding of miR-664a-5p to HIPK2 mRNA, the levels of relative proteins and autophagy...
January 7, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38183356/degradation-of-azgp1-suppresses-apoptosis-and-facilitates-cholangiocarcinoma-tumorigenesis-via-trim25
#19
JOURNAL ARTICLE
Hyeseon Yun, Hong-Rae Jeong, Do Yeon Kim, Ji-Eun You, Ji-U Lee, Dong-Hee Kang, Dong-In Koh, Yea Seong Ryu, SeungGeon Bae, Dong-Hoon Jin
Alpha-2-Glycoprotein 1, Zinc-binding (AZGP1, ZAG) is a secreted protein that is synthesized by adipocytes and epithelial cells; it is downregulated in several malignancies such as breast, prostate, liver and lung cancers. However, its function remains unclear in cholangiocarcinoma (CCA). Here, we evaluated the impact AZGP1 in CCA using Gene Expression Omnibus (GEO) and GEPIA. In addition, we analysed AZGP1 expression using quantitative reverse transcription PCR and western blotting. Expression of AZGP1 was nearly deficient in CCA patients and cell lines and was associated with poor prognosis...
January 6, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38169083/identification-and-validation-of-cuproptosis-related-molecular-clusters-in-non-alcoholic-fatty-liver-disease
#20
JOURNAL ARTICLE
Changxu Liu, Zhihao Fang, Kai Yang, Yanchao Ji, Xiaoxiao Yu, ZiHao Guo, Zhichao Dong, Tong Zhu, Chang Liu
Non-alcoholic fatty liver disease (NAFLD) is a major chronic liver disease worldwide. Cuproptosis has recently been reported as a form of cell death that appears to drive the progression of a variety of diseases. This study aimed to explore cuproptosis-related molecular clusters and construct a prediction model. The gene expression profiles were obtained from the Gene Expression Omnibus (GEO) database. The associations between molecular clusters of cuproptosis-related genes and immune cell infiltration were investigated using 50 NAFLD samples...
January 3, 2024: Journal of Cellular and Molecular Medicine
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