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Journal of Cellular and Molecular Medicine

Haoran Miao, Fan Qiu, Bing Huang, Xiucheng Liu, Hao Zhang, Zhiwei Liu, Yanliang Yuan, Qixiang Zhao, Hu Zhang, Hongyan Dong, Zhongming Zhang
Both decreased autophagy positive regulator AMP activated protein kinase (AMPK) level and promoted mitophagy are observed in oxygen-glucose deprivation (OGD) cardiomyocytes treated with pigment epithelium-derived factor (PEDF). This contradictory phenomenon and its underlying mechanisms have not been thoroughly elucidated. Our previous study reveals that PEDF increases the protein kinase Cα (PKCα) and phospho-PKCα (p-PKCα) contents to promote mitophagy. Thus, we investigated the association between PKCα and mitophagy...
September 19, 2018: Journal of Cellular and Molecular Medicine
Tongxin Wang, Weilei Yao, Yafei Shao, Ruilong Zheng, Feiruo Huang
The P300/CBP-associating factor (PCAF), a histone acetyltransferase, is involved in metabolic and pathogenic diseases, particularly of the liver. The effects of PCAF on fine-tuning liver diseases are extremely complex and vary according to different pathological conditions. This enzyme has dichotomous functions, depending on differently modified sites, which regulate the activities of various enzymes, metabolic functions, and gene expression. Here, we summarize the most recent findings on the functions and targets of PCAF in various metabolic and immunological processes in the liver and review these new discoveries and models of PCAF biology in three areas: hepatic metabolic syndrome, inflammatory disease, and cancer...
September 14, 2018: Journal of Cellular and Molecular Medicine
Richard Pentz, Christoph Kaun, Barbara Thaler, Stefan Stojkovic, Max Lenz, Konstantin A Krychtiuk, Andreas Zuckermann, Kurt Huber, Johann Wojta, Philipp J Hohensinner, Svitlana Demyanets
Interleukin (IL)-33 is a member of the IL-1 family and is able to act cardioprotective. The aim of this study was to investigate the regulation of IL-33 by 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors (statins) and bisphosphonates (BPs) in human cardiac tissue. The lipophilic fluvastatin, simvastatin, atorvastatin, and lovastatin as well as the nitrogenous BPs alendronate and ibandronate, but not hydrophilic pravastatin increased IL-33 mRNA and intracellular IL-33 protein levels in both human adult cardiac myocytes (HACM) and fibroblasts (HACF)...
September 14, 2018: Journal of Cellular and Molecular Medicine
Scott R Burks, Matthew E Nagle, Michele N Bresler, Saejeong J Kim, Robert A Star, Joseph A Frank
Mesenchymal stromal cell (MSC) therapies combined with renal pulsed focused ultrasound (pFUS) pretreatment increase MSC homing and improve cisplatin-induced acute kidney injury (AKI) better than MSC alone. However, mechanisms underlying improved outcomes remain unknown. We hypothesize pFUS up-regulates renal interferon-γ (IFNγ) and stimulates MSC to produce interleukin-10 (IL-10) after migrating to kidneys. To demonstrate initially, MSC cultured with IFNγ up-regulated IL-10. More MSC-derived IL-10 was detected in kidneys when IFNγ-stimulated MSC were infused and they improved AKI better than unstimulated MSC...
September 14, 2018: Journal of Cellular and Molecular Medicine
Lei Pei, Yirong Kong, Changfeng Shao, Xiao Yue, Zongling Wang, Na Zhang
BACKGROUND: Concerns about breast cancer had become the most dangerous cancer to women over the world, more and more anti-cancer agents are developed to treat this malignancy. Pharmorubicin is a cytotoxic drug, widely used in the treatment of breast cancer, but its role is limited because of chemoresistance produced by cells. This study focused on exploring the influence of autophagy on the resistance of pharmorubicin in breast cancer cells. METHODS: The cell survival of breast cancer cells was detected by MTT...
September 14, 2018: Journal of Cellular and Molecular Medicine
Xiaodong Shen, Guoxin Han, Shuoshuo Li, Yang Song, Hong Shen, Yongzhi Zhai, Yingchan Wang, Fei Zhang, Ning Dong, Tanshi Li, Yongming Yao, Haiyan Zhu
To search for an association between sepsis and mitochondrial genetic basis, we began our study. In this study, a proband harbouring mitochondrial T6459C mutation with sepsis and his Chinese Han pedigree including 7 members of 3 generations were enrolled. General information, blood parameters and mitochondrial full sequence scanning of all members were performed, and cellular functions, including cellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP), degrees of cell apoptosis and adenosine triphosphate (ATP) concentrations, were measured in members with and without the T6459C mutation...
September 11, 2018: Journal of Cellular and Molecular Medicine
Kaori Suyama, Daisuke Sakai, Noriaki Hirayama, Yoshihiko Nakamura, Erika Matsushita, Hayato Terayama, Ning Qu, Osamu Tanaka, Kou Sakabe, Masahiko Watanabe
Intervertebral discs (IVD) degeneration, which is caused by ageing or mechanical stress, leads to IVD disease, including back pain and sciatica. The cytokine interleukin (IL)-17A is elevated in NP cells during IVD disease. Here we explored the pharmacotherapeutic potential of IL-17A for the treatment of IVD disease using small-molecule inhibitors that block binding of IL-17A to the IL-17A receptor (IL-17RA). Treatment of NP cells with IL-17A increased expression of cyclooxygenase-2 (COX-2), IL-6, matrix metalloproteinase (MMP)-3 and MMP-13...
September 11, 2018: Journal of Cellular and Molecular Medicine
Olusegun O Onabajo, Mark G Lewis, Joseph J Mattapallil
Human immunodeficiency virus (HIV) infection is characterized by dysfunctional B cell responses. Here we show that chronic simian immunodeficiency virus (SIV) infection is characterized by an expansion of either lymph node germinal center (GC) B cells that co-express Bcl6, Ki-67 and IL-21R and correlate with expanded T follicular helper (Tfh) cells or B cells that lack Bcl6, Ki-67 and IL-21R but express high levels of anti-apoptotic Bcl2 that negatively correlate with Tfh cells. The lack of Tfh cells likely contributes to persistence of dysfunctional non-proliferating B cells during chronic infection...
September 6, 2018: Journal of Cellular and Molecular Medicine
Małgorzata Tomczyńska, Ireneusz Salata, Michał Bijak, Joanna Saluk-Bijak
The blood platelets are multifunctional blood cells which are involved in the initiation of atheroma, endothelial dysfunction, and modulation of inflammatory and immune responses in the pathophysiology of many diseases. Because of their multifaceted pro-inflammatory activity, platelets may be involved in the pathogenesis of autoimmune thyroid diseases (AITDs), such as Hashimoto's thyroiditis and Graves' disease. The aim of this study was to assess the level of activation and response ability of platelets in AITDs...
September 6, 2018: Journal of Cellular and Molecular Medicine
Scott D Barnett, Iain L O Buxton
Preterm birth before 37 weeks of completed gestation results in numerous health consequences for the foetus. Preterm labour leads to preterm birth in over 50% of cases, and no FDA-approved treatment can prevent labour or help a foetus remain in the womb until term. Examination of nitric oxide mediated relaxation signaling in the uterine smooth muscle reveals a role for protein S-nitrosation. The recent discovery of upregulated S-nitrosoglutathione reductase (GSNOR) in spontaneously preterm labouring women has emphasized the need to explore the function of S-nitrosation regulation in the maintenance of uterine quiescence...
September 6, 2018: Journal of Cellular and Molecular Medicine
Ying Huang
Long noncoding RNAs (lncRNAs) are RNAs longer than 200 nt in length that are characterized by low levels of sequence conservation and expression; lncRNAs modulate various biological functions at epigenetic, transcriptional and post-transcriptional levels, or directly regulate protein activity. As a family of small and evolutionarily conserved noncoding RNAs, microRNAs (miRNAs) are capable of regulating physiological and pathological processes via inhibiting target mRNA translation or promoting mRNA degradation...
September 6, 2018: Journal of Cellular and Molecular Medicine
Shameer J Mehta, Amy Lewis, Anke Nijhuis, Rosemary Jeffery, Paolo Biancheri, Antonio Di Sabatino, Roger Feakins, Andrew Silver, James Oliver Lindsay
Intestinal mesenchymal cells deposit extracellular matrix in fibrotic Crohn's disease (CD). The contribution of epithelial to mesenchymal transition (EMT) to the mesenchymal cell pool in CD fibrosis remains obscure. The miR-200 family regulates fibrosis-related EMT in organs other than the gut. E-cadherin, cytokeratin-18 and vimentin expression was assessed using immunohistochemistry on paired strictured (SCD) and non-strictured (NSCD) ileal CD resections and correlated with fibrosis grade. MiR-200 expression was measured in paired SCD and NSCD tissue compartments using laser capture microdissection and RT-qPCR...
September 6, 2018: Journal of Cellular and Molecular Medicine
Yongliang Ni, Xin Wang, Xiaoxuan Yin, Yan Li, Xigao Liu, Haixin Wang, Xiangjv Liu, Jun Zhang, Haiqing Gao, Benkang Shi, Shaohua Zhao
Podocyte injury is an early pathological change characteristic of various glomerular diseases, and apoptosis and F-actin cytoskeletal disruption are typical features of podocyte injury. In this study, we found that adriamycin (ADR) treatment resulted in typical podocyte injury and repressed plectin expression. Restoring plectin expression protected against ADR-induced podocyte injury whereas siRNA-mediated plectin silencing produced similar effects as ADR-induced podocyte injury, suggesting that plectin plays a key role in preventing podocyte injury...
September 6, 2018: Journal of Cellular and Molecular Medicine
Alexios-Fotios A Mentis, Athanasios G Papavassiliou
No abstract text is available yet for this article.
September 6, 2018: Journal of Cellular and Molecular Medicine
Junfeng Shi, Yi Chen, Wenxing Chen, Cuiju Tang, Honghong Zhang, Yuetong Chen, Xiuwei Yang, Zhi Xu, Jingsun Wei, Jinfei Chen
Oestrogen receptor (ER) is expressed in approximately 60%-70% of human breast cancer. Clinical trials and retrospective analyses have shown that ER-positive (ER+) tumours are more tolerant to chemotherapeutic drug resistance than ER-negative (ER-) tumours. In addition, isobavachalcone (IBC) is known as a kind of phytoestrogen with antitumour effect. However, the underlying mechanism of IBC in ER+ breast cancer needs to be elucidated further. Our in vitro experiments showed that IBC could attenuate 17β-estradiol (E2 )-induced paclitaxel resistance and that E2 could stimulate CD44 expression in ER+ breast cancer cells but not in ER- cells...
September 4, 2018: Journal of Cellular and Molecular Medicine
Zongcheng Feng, Hongrun Chen, Taozhu Fu, Lianfeng Zhang, Yushan Liu
The treatment of complicated long segment strictures remains to a challenge, and the substitution urethroplasty treatment is often accompanied by subsequent tissue fibrosis and secondary stricture formation. In situ injection of human adipose tissue-derived stem cells (hADSC) could potential be applied for prevention of urethral fibrosis, but the cells transplantation alone may be insufficient because of the complicated histopathological micro-environmental changes in the injury site. This study investigated whether miR-21 modification can improve the therapeutic efficacy of ADSCs against urethral fibrosis to limit urethral stricture recurrence...
September 4, 2018: Journal of Cellular and Molecular Medicine
Zhaohua Zhang, Chao Sun, Jue Wang, Wen Jiang, Qian Xin, Yun Luan
The aim of this study is to optimize the timing of erythropoietin gene modified mesenchymal stem cells (EPO-MSCs) transplantation for bronchopulmonary dysplasia (BPD). Three weeks post-operation, the results indicated that the damage of airway structure and apoptosis were significantly decreased, the proliferation was increased in three EPO-MSCs transplantation groups as compared with BPD mice. Moreover, the inflammation cytokines were improvement in early EPO-MSCs injection mice than in BPD mice, but there was no significant difference between late injection and BPD groups...
August 30, 2018: Journal of Cellular and Molecular Medicine
Andrés Trávez, Yoana Rabanal-Ruiz, Jaime López-Alcalá, Laura Molero-Murillo, Alberto Díaz-Ruiz, Rocío Guzmán-Ruiz, Victoria Catalán, Amaia Rodríguez, Gema Frühbeck, Francisco J Tinahones, Stéphane Gasman, Nicolas Vitale, Yolanda Jiménez-Gómez, María M Malagón
Adipocyte dysfunction in obesity is commonly associated with impaired insulin signalling in adipocytes and insulin resistance. Insulin signalling has been associated with caveolae, which are coated by large complexes of caveolin and cavin proteins, along with proteins with membrane-binding and remodelling properties. Here, we analysed the regulation and function of a component of caveolae involved in growth factor signalling in neuroendocrine cells, neuroendocrine long coiled-coil protein-2 (NECC2), in adipocytes...
August 30, 2018: Journal of Cellular and Molecular Medicine
Hao Yao, Jun Fan, Yun-Jiu Cheng, Xu-Miao Chen, Cheng-Cheng Ji, Li-Juan Liu, Zi-Heng Zheng, Su-Hua Wu
BACKGROUND: Abnormal cardiac ion channels current, including transient outward potassium current (Ito ), is associated with early repolarization syndrome (ERS). Previous studies showed that mutations in SCN1Bβ both to increase the Ito current and to decrease the sodium current. Yet its role in ERS remains unknown. OBJECTIVE: To determine the role of mutations in the SCN1Bβ subunits in ERS. METHODS: We screened for mutations in the SCN1B genes from four families with ERS...
August 30, 2018: Journal of Cellular and Molecular Medicine
Yun-Fei Xu, Hong-Da Liu, Zeng-Li Liu, Chang Pan, Xiao-Qing Yang, Shang-Lei Ning, Zong-Li Zhang, Sen Guo, Jin-Ming Yu
Fibroblast growth factor receptor 2 (FGFR2) was demonstrated to correlate to the progression and prognosis of intrahepatic cholangiocarcinoma (ICC) by numerous evidences. However, as a well-recognized suppressor of FGFR2 signalling, the clinical significance of Sprouty (SPRY) family of ICC has not been investigated. In our study, the expressions of SPRY1-4 in 20 pairs of fresh tumour tissues were detected with qPCR, and in 108 cases of paraffin-embedded tissues with immunohistochemistry. The prognostic value of SPRY family in ICC was estimated with univariate analysis and multivariate analysis...
August 30, 2018: Journal of Cellular and Molecular Medicine
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