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American Journal of Alzheimer's Disease and Other Dementias

Barbara Resnick, Elizabeth Galik, Ann Kolanowski, Kimberly Van Haitsma, Marie Boltz, Jeanette Ellis, Liza Behrens, Nina M Flanagan
BACKGROUND/RATIONALE: This study tested the psychometric properties of the Quality of Life in Late-Stage Dementia (QUALID) Scale using Rasch analysis. The QUALID includes 11 items with a 5-point response scale. Scores range from 11 to 55, and lower scores indicate higher quality of life (QoL). METHODS: Baseline data from a randomized clinical trial including 137 residents from 14 nursing homes were used. Psychometric testing included item mapping, evaluation of response categories, item reliability, construct validity based on INFIT and OUTFIT statistics, and convergent validity based on correlations between QoL and pain, agitation, depression, and function...
August 2018: American Journal of Alzheimer's Disease and Other Dementias
Gabriele Cipriani, Sabrina Danti, Cecilia Carlesi, Mario Di Fiorino
BACKGROUND: People with Down syndrome (DS) enjoy a longer life expectancy now than they ever have before and are therefore at greater risk of developing conditions associated with aging, including dementia. OBJECTIVES: To explore the phenomenon of dementia in DS. METHODS: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published until 2017. Search terms included Alzheimer's disease, cognitive impairment, dementia, DS, and trisomy 21...
June 2018: American Journal of Alzheimer's Disease and Other Dementias
John Zeisel, Michael J Skrajner, Evan B Zeisel, Miranda Noelle Wilson, Chris Gage
Scripted-IMPROV (SI) is a nonpharmacological (ecopsychosocial) intervention that consists of semi-improvised drama performances specifically designed for persons with dementia (PWD). In this 12-site study, 178 PWD took part in the SI intervention. Levels of engagement/affect were assessed at baseline and again during SI performances; quality of life (via the Dementia Quality of Life scale) and depression (via the Geriatric Depression Scale-Short Form [GDS-SF]) were assessed at baseline and post-treatment. Positive forms of engagement/affect increased, while negative forms of engagement decreased...
June 2018: American Journal of Alzheimer's Disease and Other Dementias
Elizabeth Galik, Sarah Holmes, Barbara Resnick
INTRODUCTION: The purpose of this study was to test differences in psychotropic medication, function, physical activity, agitation, resistiveness to care, comorbidities, and depression among moderate to severely cognitively impaired nursing home residents who were fallers versus nonfallers. METHODS: This was a secondary data analysis using baseline data from a randomized controlled trial testing the Function and Behavior Focused Care intervention across 12 nursing homes...
June 2018: American Journal of Alzheimer's Disease and Other Dementias
Bieke Van Deun, Nele Van den Noortgate, Saucedo Cinthia, Anke Van Bladel, Cambier Dirk
BACKGROUND: Paratonia is a major underlying motor problem impeding functionality and locomotion in dementia. Despite its undeniable impact on patient's quality of life and daily care, there is a lack of evidence-based therapy on patients with this condition. METHODS: We surveyed physiotherapists working in nursing homes in Flanders (Belgium) concerning the use and perceived effect of therapeutic strategies and positioning methods/aids. RESULTS: Positioning and soft passive mobilization were the most applied and positively appraised therapeutic interventions...
June 2018: American Journal of Alzheimer's Disease and Other Dementias
Timothy Thoits, Alison Dutkiewicz, Sarah Raguckas, Michael Lawrence, Jessica Parker, Jacob Keeley, Nicholas Andersen, Martha VanDyken, Maegan Hatfield-Eldred
OBJECTIVE: Early diagnosis of dementia leads to early treatment which is beneficial to patients and the community. We reviewed initial evaluations from the Spectrum Health Medical Group Neurocognitive Clinic (SHMGNC) to evaluate dementia stage at the time of diagnosis. METHODS: We retrospectively reviewed 110 randomly chosen initial evaluations from September 2008 to December 2015 at the SHMGNC. Patients underwent a neurological examination, Montreal Cognitive Assessment, and a battery of neuropsychological testing...
June 2018: American Journal of Alzheimer's Disease and Other Dementias
Manal Galal Abd El Wahab, Soad Shaker Ali, Nasra Naeim Ayuob
OBJECTIVE: This study aimed to evaluate the effect induced by musk on Alzheimer's disease-such as neurodegenerative changes in mice exposed to chronic unpredictable mild stress (CUMS). MATERIAL AND METHODS: Forty male Swiss albino mice were divided into 4 groups (n = 10); control, CUMS, CUMS + fluoxetine, CUMS + musk. At the end of the experiment, behavior of the mice was assessed. Serum corticosterone level, hippocampal protein level of the glucocorticoid receptors, and brain-derived neurotropic factor were also assessed...
June 2018: American Journal of Alzheimer's Disease and Other Dementias
Robert Haussmann, René Mayer-Pelinski, Maike Borchardt, Fabrice Beier, Franziska Helling, Maria Buthut, Gisa Meissner, Jan Lange, Anne Zweiniger, Markus Donix
Diagnostic assessments for dementia include the evaluation of subjective memory impairment, dementia worries, or depressive symptoms. Data on the predictive value of these factors remain unclear, and varying help-seeking behavior may contribute to this finding. We investigate whether differentiating help-seeking motivation from other psychological factors associated with cognitive impairment would enhance the prediction of diagnostic outcomes in a memory clinic. We obtained information on help-seeking motivation from 171 patients who underwent routine diagnostic assessments...
June 2018: American Journal of Alzheimer's Disease and Other Dementias
Sarah Tomaszewski Farias, Maureen Schmitter-Edgecombe, Alyssa Weakley, Danielle Harvey, Katherine G Denny, Cheyanne Barba, Jason T Gravano, Tania Giovannetti, Sherry Willis
BACKGROUND/RATIONALE: Compensation strategies may contribute to greater resilience among older adults, even in the face of cognitive decline. This study sought to better understand how compensation strategy use among older adults with varying degrees of cognitive impairment impacts everyday functioning. METHODS: In all, 125 older adults (normal cognition, mild cognitive impairment, dementia) underwent neuropsychological testing, and their informants completed questionnaires regarding everyday compensation and cognitive and functional abilities...
May 2018: American Journal of Alzheimer's Disease and Other Dementias
Luke W Bonham, Daniel S Evans, Yongmei Liu, Steven R Cummings, Kristine Yaffe, Jennifer S Yokoyama
BACKGROUND/RATIONALE: Experimental studies support the role of neurotransmitter genes in dementia risk, but human studies utilizing single variants in candidate genes have had limited success. METHODS: We used the gene-based testing program Versatile Gene-based Association Study to assess whether aggregate variation across 6 neurotransmitter pathways influences risk of cognitive decline in 8159 cognitively normal elderly (≥65 years old) adults from 3 community-based cohorts...
May 2018: American Journal of Alzheimer's Disease and Other Dementias
Sheryl Zimmerman, Philip D Sloane, Kimberly Ward, Anna Beeber, David Reed, Christine Lathren, Bobbi Matchar, Lisa Gwyther
BACKGROUND/RATIONALE: Family caregivers of people with dementia must attend to medical care needs of their relative, yet few available resources address comorbidities in dementia. Consequently, caregivers feel ill-equipped when medical concerns arise. In response, an educational resource-Alzheimer's Medical Advisor ( AlzMed)-was developed in 2 forms (website and book) and evaluated. METHODS: Family caregivers (143 website and 51 book) used an educational resource that provides information on medical problems, vital signs, pain, dehydration, and the healthcare system...
May 2018: American Journal of Alzheimer's Disease and Other Dementias
Faten Atlam, Mohamed Awad, Rehab Salama
Density functional theory (B3LYP/6-31G [d]) is performed to study the effect of molecular and electronic structures of the investigated β-secretase 1 (BACE1) Alzheimer's inhibitors on their biological activities and discuss the correlation between their inhibition efficiencies and quantum chemical descriptors. IC50 values of the investigated compounds are mostly affected by the substituted R2 phenyl moiety. The calculations show that the presence of electron withdrawing group increases the half maximal inhibitory concentration (IC50 )...
May 2018: American Journal of Alzheimer's Disease and Other Dementias
Andrea Gilmore-Bykovskyi, Rachel Johnson, Lily Walljasper, Laura Block, Nicole Werner
Women and racial/ethnic minority dementia caregivers have unique caregiving experiences and support needs. To ensure the identification of potentially important differences in outcomes within these groups, the amended National Institutes of Health (NIH) Policy on Inclusion of Women and Minorities mandates reporting by gender and race/ethnicity. The objective of this study was to determine the inclusion and reporting rates among NIH-funded dementia caregiver support interventions. A focused systematic literature review of studies published from 1994 to 2015 located 48 articles meeting inclusion criteria...
May 2018: American Journal of Alzheimer's Disease and Other Dementias
Li-Jung Elizabeth Ku, Chung-Yi Li, Yu Sun
Although cholinesterase inhibitors (ChEIs) have been proved to help reduce cognitive deterioration in patients with Alzheimer's disease (AD), their effects on survival remain inconclusive. This study aims to assess the effects of the persistent use of ChEIs on the risk of mortality in patients with AD. This population-based cohort study included 8614 patients having AD with ChEI prescription from 2002 to 2006 and followed until 2010. Kaplan-Meier curves and hazard ratios (HRs) of mortality were estimated in association with ChEI treatment duration and adherence...
March 2018: American Journal of Alzheimer's Disease and Other Dementias
Fabiano Moulin de Moraes, Paulo Ferreira Bertolucci
INTRODUCTION: Supplementary tests are part of the clinical approach to diagnose cognitive impairment. We aimed to determine the role of supplementary examinations, except for biomarkers, on diagnostic stability of dementia over time and to identify reversible dementias. METHODS: We identified 432 patients with dementia who performed 2 clinical evaluations and the supplementary examinations recommended by the American Academy of Neurology in a follow-up period of 1 year...
March 2018: American Journal of Alzheimer's Disease and Other Dementias
Maria do Céu Ferreira, Maria João Abreu, Célia Machado, Beatriz Santos, Álvaro Machado, Ana Sofia Costa
BACKGROUND: The aim of this study was to investigate the frequency and severity of neuropsychiatric symptoms (NPS) in patients with early onset Alzheimer's disease (EAOD) and late onset AD (LOAD). METHODS: Patients were selected from a specialized memory outpatient clinic. The Mini-Mental State Examination, the Neuropsychiatric Inventory (NPI), and the Global Deterioration Scale results were analyzed. RESULTS: By comparing EOAD (n = 35) and LOAD (n = 35) patients, no significant differences were found in clinical or demographic variables, matched for sex, education, and disease severity...
March 2018: American Journal of Alzheimer's Disease and Other Dementias
Eunsaem Kim, Sarah Ullrich-French, Cory Bolkan, Laura Griner Hill
This study examined the determinants of physical activity (PA) for older adults with Alzheimer's disease (AD) to learn more about how to promote PA in this population. Caregivers of older adults with AD (N = 99) provided information related to care recipient's PA, as well as addressed sociodemographics and perceptions about their care recipient's PA. Gender of care recipient was a significant predictor of PA (β = .80, P < .05); men with AD participated in more PA than women with AD. Also, caregiver's outcome expectation for care recipient's PA also predicted more PA (β = ...
March 2018: American Journal of Alzheimer's Disease and Other Dementias
Giulia Perugia, Daniel Rodríguez-Martín, Marta Díaz Boladeras, Andreu Català Mallofré, Emilia Barakova, Matthias Rauterberg
Engagement in activities is crucial to improve quality of life in dementia. Yet, its measurement relies exclusively on behavior observation and the influence that behavioral and psychological symptoms of dementia (BPSD) have on it is overlooked. This study investigated whether quantity of movement, gauged with a wrist-worn accelerometer, could be a sound measure of engagement and whether apathy and depression negatively affected engagement. Fourteen participants with dementia took part in 6 sessions of activities: 3 of cognitive games (eg, jigsaw puzzles) and 3 of robot play (Pleo)...
March 2018: American Journal of Alzheimer's Disease and Other Dementias
Blake Barrett, Tatjana Bulat, Susan K Schultz, Stephen L Luther
OBJECTIVE: To investigate baseline factors associated with caregiver-reported wandering among community-dwelling veterans with mild dementia. METHODS: Veterans with mild dementia (N = 143) and their caregivers participated in a 2-year prospective longitudinal study. Measures assessed wandering, daily function, behavior, cognition, and personality features. Wandering was dichotomized as present or absent across study periods, and associations with baseline characteristics were examined...
March 2018: American Journal of Alzheimer's Disease and Other Dementias
Vinod Kaushik, Sarah Toombs Smith, Emmanuel Mikobi, Mukaila A Raji
Elderly patients with Alzheimer's disease (AD) and other dementias are at high risk of polypharmacy and excessive polypharmacy for common coexisting medical conditions. Polypharmacy increases the risk of drug-drug and drug-disease interactions in these patients who may not be able to communicate early symptoms of adverse drug events. Three acetylcholinesterase inhibitors (ACHEIs) have been approved for AD: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). They are also used off-label for other causes of dementia such as Lewy body and vascular dementia...
March 2018: American Journal of Alzheimer's Disease and Other Dementias
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