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American Journal of Alzheimer's Disease and Other Dementias

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https://www.readbyqxmd.com/read/28871793/utility-of-montreal-cognitive-assessment-in-differentiating-dementia-with-lewy-bodies-from-alzheimer-s-dementia
#1
Erin Yamamoto, Lyla Mourany, Rosemary Colleran, Christine Whitman, Babak Tousi
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common neurodegenerative dementias. Identification of patients with DLB is necessary to guide appropriate clinical management and medication trials. Patients with DLB are reported to perform poorly on tasks of visuospatial and executive function, compared to patients with AD who perform poorly on memory tasks. Using the Montreal Cognitive Assessment, we found that patients with DLB (n = 73) had statistically significant lower performance in clock drawing (visuospatial and executive function) and higher performance in delayed recall (memory) subscores compared to patients with AD (n = 57)...
December 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28660777/diogenes-syndrome-in-frontotemporal-dementia
#2
Catherine M Finney, Mario F Mendez
Diogenes syndrome refers to the combination of extreme self-neglect and excessive collecting with clutter and squalor, which is often present in patients with dementia. Diogenes syndrome may be particularly common in behavioral variant frontotemporal dementia (bvFTD), and the investigation of these patients may help clarify the nature of this syndrome. We describe 5 patients with bvFTD who exhibited a decline in self-care accompanied by hoarding behaviors. These patients, and a review of the literature, suggest a combination of frontal lobe disturbances: loss of insight or self-awareness with a failure to clean up or discard, a general compulsive drive, and an innate impulse to take environmental items...
November 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28558474/development-and-testing-of-a-measure-of-caregiver-confidence-in-medical-sign-symptom-management
#3
Cleveland A Piggott, Sheryl Zimmerman, David Reed, Philip D Sloane
Evaluation of efforts to support family caregivers of people with dementia in their daily medical management responsibilities requires a measure of caregiver self-efficacy (confidence). This article describes the development and psychometric properties of the Caregiver Confidence in Sign/Symptom Management (CCSM) scale, the only available instrument in this area. Measurement development included literature and expert panel review, cognitive testing, and field testing. The CCSM is a 25-item measure (α = .92) composed of confidence in relation to 4 subscales: knowledge of signs/symptoms (α = ...
November 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28554217/oxidative-stress-markers-and-metal-ions-are-correlated-with-cognitive-function-in-alzheimer-s-disease
#4
Zhengping Pu, Wenjie Xu, Yong Lin, Jincai He, Manli Huang
We investigated oxidative stress markers and metal ions in patients with Alzheimer's disease (AD). The serum levels of ceruloplasmin (CER), C-reactive protein (CRP), uric acid (UA), homocysteine (Hcy), copper, iron, and zinc were determined in 125 patients with AD (mild, n = 2 8; moderate, n = 42; and severe, n = 55) and 40 healthy control (HC) participants. Compared to HC, CER and UA levels were significantly lower in moderate and severe AD groups, whereas CRP and Hcy levels were significantly higher in the severe AD group...
September 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28449585/elevated-plasma-a%C3%AE-42-in-cognitively-impaired-individuals-taking-ace-inhibitor-antihypertensives
#5
William T Regenold, Jacob B Blumenthal, David J Loreck, Kristen L Mordecai, Gina Scarinzi, Seshagiri R Doddi, Lawrence Adler
BACKGROUND/RATIONALE: Accumulating evidence suggests that the use of angiotensin-converting enzyme inhibitor (ACE-I) medication protects against cognitive decline in the elderly patients. We investigated whether ACE-I use was associated with higher plasma levels of amyloid-β (Aβ), possibly indicating improved Aβ clearance from brain to blood. METHODS: We measured and compared plasma concentrations of Aβ42, Aβ40, and creatinine in cognitively impaired individuals with amnestic mild cognitive impairment, probable Alzheimer's disease (AD) dementia, and mixed probable AD/vascular dementia...
September 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28446028/impact-of-nutritional-supplementation-and-a-psychomotor-program-on-patients-with-alzheimer-s-disease
#6
Odete Vicente de Sousa, Rita Soares Guerra, Ana Sofia Sousa, Bebiana Pais Henriques, Anabela Pereira Monteiro, Teresa Freitas Amaral
This study aims to evaluate the impact of oral nutritional supplementation (ONS) and a psychomotor rehabilitation program on nutritional and functional status of community-dwelling patients with Alzheimer's disease (AD). A 21-day prospective randomized controlled trial was conducted and third intervention group performed a psychomotor rehabilitation program. Patients were followed up for 180 days. Mean (standard deviation) score of Mini Nutritional Assessment (MNA) increased both in the nutritional supplementation group (NSG; n = 25), 0...
September 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28612623/frontal-tasks-and-behavior-in-rigid-or-tremor-dominant-parkinson-disease
#7
Rita Moretti, Vera Milner, Paola Caruso, Silvia Gazzin, Raffaella Rumiati
Parkinson disease (PD) is not an unambiguous entity, and there is a general consensus for the statement that an akinetic-rigid dominant type of presentation has a worse prognosis, in the follow-up. The aim of our study was to examine the differences in frontal tasks and behavior, in 2 PD naive groups: the rigid and the tremor-dominant types of presentation, according to motor scores. Our study has showed some important differences in frontal tasks and in behavior, performing more apathy, aggressiveness, and irritability in the rigid type, and more depression and anxiety in the tremor-dominant type...
August 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28605999/the-influence-of-psychosocial-and-cognitive-factors-on-perceived-threat-of-alzheimer-s-disease
#8
Jenny E Ostergren, Steven G Heeringa, Carlos F Mendes de Leon, Cathleen M Connell, J Scott Roberts
This study explored psychosocial and cognitive predictors of perceived threat of Alzheimer's disease (AD). Respondents were 1641 adults (mean age: 64.4; 54% female; 82% white) who completed a module in the Health and Retirement Study, a nationally representative survey of adults aged ≥50. Findings show that perceived threat was significantly higher for those aged 50 to 64 ( P < .001) and 65 to 74 ( P < .05) than for those ≥75. Respondents with a family history of AD had significantly greater perceived threat ( P < ...
August 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28506126/intergenerational-programs-may-be-especially-engaging-for-aged-care-residents-with-cognitive-impairment-findings-from-the-avondale-intergenerational-design-challenge
#9
Jess Rose Baker, Lindl Webster, Nigel Lynn, Julie Rogers, Jessica Belcher
Intergenerational programs are an authentic way to engage elders in meaningful activity and report benefits to both elders and youth. The Avondale Intergenerational Design Challenge (AVID) randomly assigned small teams of technology students aged 13 to 15 years (total N = 59) to 1 of 24 aged care residents with a range of cognitive impairment. Students met with the resident 4 times over 15 weeks and ultimately crafted a personalized item for them. Students showed no change in self-reported attitudes to elders, empathy, or self-esteem post-AVID or at 3-month follow-up, compared to a 3-month within-subject control period pre-AVID...
June 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28403621/examining-factors-affecting-caregiver-burden-a-comparison-of-frontotemporal-dementia-and-alzheimer-s-disease
#10
Özlem Küçükgüçlü, Burcu Akpınar Söylemez, Görsev Yener, Canan Demir Barutcu, Merve Aliye Akyol
This study was conducted to compare the caregiver burden with regard to Alzheimer's disease (AD) and frontotemporal dementia (FTD) and to determine the factors affecting the caregiver burden of patients with AD and FTD. A comparative descriptive study design was used. The sample consisted of 90 patients with AD and 44 patients with FTD and their caregivers. Sociodemographic questionnaire, Mini-Mental State Examination (MMSE), the Caregiver Burden Inventory (CBI), Neuropsychiatric Inventory (NPI), and Functional Activities Questionnaire (FAQ) were used...
June 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28357874/gender-s-effects-to-the-early-symptoms-of-alzheimer-s-disease-in-5-asian-countries
#11
Yuan-Han Yang, Kenichi Meguro, Jacqueline Dominguez, Christopher Li-Hsian Chen, Huali Wang, Paulus Anam Ong
BACKGROUND: Asia has the greatest population and more patients with dementia in the world. Early recognition of clinical symptoms of Alzheimer's disease (AD) is crucial for dementia care. In order to foster collaboration in AD care, a uniformed manner to report the early clinical symptoms of AD is necessary. METHODS: We have recruited clinically diagnosed patients with AD at their very mild stage with Clinical Dementia Rating (CDR) 0.5 in Taiwan, Japan, China, Philippines, and Singapore...
June 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28423938/validation-of-the-turkish-version-of-the-quick-mild-cognitive-impairment-screen
#12
Burcu Balam Yavuz, Hacer Dogan Varan, Rónán O'Caoimh, Muhammet Cemal Kizilarslanoglu, Mustafa Kemal Kilic, D William Molloy, Rana Tuna Dogrul, Erdem Karabulut, Anton Svendrovski, Aykut Sağır, Eylem Sahin Cankurtaran, Yusuf Yesil, Mehmet Emin Kuyumcu, Meltem Halil, Mustafa Cankurtaran
BACKGROUND: The objective of this study was to validate the Turkish version of the Quick Mild Cognitive Impairment (Q mci-TR) screen. METHODS: In total, 100 patients aged ≥65 years referred to a geriatric outpatient clinic with memory loss were included. The Q mci was compared to the Turkish versions of the standardized Mini-Mental State Examination and the Montreal Cognitive Assessment (MoCA). RESULTS: The Q mci-TR had higher accuracy than the MoCA in discriminating subjective memory complaints (SMCs) from cognitive impairment (mild cognitive impairment [MCI] or dementia), of borderline significance after adjusting for age and education ( P = ...
May 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28423937/concordance-of-several-subcellular-interactions-initiates-alzheimer-s-dementia-their-reversal-requires-combination-treatment
#13
REVIEW
W J Fessel
The pathogenesis of Alzheimer's disease involves multiple pathways that, at the macrolevel, include decreased proliferation plus increased loss affecting neurons, astrocytes, and capillaries and, at the subcellular level, involve several elements: amyloid/amyloid precursor protein, presenilins, the unfolded protein response, the ubiquitin/proteasome system, the Wnt/catenin system, the Notch signaling system, mitochondria, mitophagy, calcium, and tau. Data presented show the intimate, anatomical interactions between neurons, astrocytes, and capillaries; the interactions between the several subcellular factors affecting those cells; and the treatments that are currently available and that might correct dysfunctions in the subcellular factors...
May 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28423936/relationship-quality-and-distress-in-caregivers-of-persons-with-dementia-a-cross-sectional-study
#14
Heidi Bjørge, Kari Kvaal, Milada Cvancarova Småstuen, Ingun Ulstein
This cross-sectional study aimed to investigate the relationship between caregivers and care receivers, defined as home-dwelling family members with dementia. We used a self-rating questionnaire, the Felt Expressed Emotion Rating Scale (FEERS; 6 simple questions), to measure caregiver perceptions of the care receiver's criticisms (CCs) and emotional overinvolvement (EOI) toward the caregiver. We performed factor analyses to rank single items on the FEERS pertaining to CC and EOI. We included 208 caregiver/care receiver pairs...
May 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28423935/supporting-simple-activity-engagement-in-persons-with-moderate-to-severe-alzheimer-s-disease-through-a-technology-aided-program
#15
Giulio E Lancioni, Nirbhay N Singh, Mark F O'Reilly, Jeff Sigafoos, Fiora D'Amico, Katia Pinto, Claudia Chiapparino
OBJECTIVES: These 2 studies assessed a technology-aided program to support mild physical exercise or simple occupational activity in participants with moderate to severe Alzheimer's disease. METHODS: Study 1 included 11 participants who were to perform a leg-raising response. Study 2 included 10 participants who were to sort objects into different containers. The program ensured that they received positive stimulation contingent on the responses and reminders/prompts after periods of nonresponding...
May 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28423934/estimating-dementia-and-receipt-of-informal-care-using-behavioral-risk-factor-surveillance-system-data
#16
Mary Adams
INTRODUCTION: Estimates of US adults with dementia differ widely and don't distinguish adults living in the community. METHODS: Behavioral Risk Factor Surveillance System data from 120 485 households in 21 states that used a cognitive decline module in 2011 were used. Data for both respondents and other adults with subjective cognitive decline (SCD) were included through proxy responses. Using responses to questions about the receipt of informal care for their SCD and diagnosed dementia, estimates were made for each state...
May 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28191798/diagnostic-validity-comparison-between-criteria-based-on-csf-alzheimer-s-disease-biomarkers
#17
COMPARATIVE STUDY
Maria Empar Blanco-Cantó, J A Monge-Argilés, C Pérez-Cejuela, C Badía, L Gabaldón, C Muñoz-Ruíz, J Sánchez-Payá, R Gasparini-Berenguer, C Leiva-Santana
AIM: To compare the diagnostic validity of NIA-AA criteria, for AD CSF biomarkers, with our own new criteria. MATERIALS AND METHODS: Between 2008 and 2011, 170 patients with Mild Cognitive Impairment (MCI) were included. CSF levels of Aβ1-42, T-tau, P-tau181, and ratios of T-tau/Aβ1-42 and P-tau181/Aβ1-42 were analyzed. In our criteria, we considered 3 or more abnormal variables indicative of a high likelihood of MCI due to AD. RESULTS: After a clinical follow-up of 4...
March 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28116927/the-relationship-between-what-we-believe-and-how-we-care-among-daughters-caring-for-a-parent-with-dementia
#18
Cory K Chen, Karima Clayton, Joshua Chodosh
This study attempted to better understand factors associated with relationship conflict between daughters and their parents with dementia. We examined data from 77 daughters self-identified as primary caregivers of a parent with dementia to test the hypothesis that daughters' belief that a parent with dementia can control their symptoms is associated with more conflict, defined as high expressed emotion (EE). Participants completed self-report questionnaires assessing beliefs about parents' ability to control symptoms, stress, relationship conflict, parent agitation, and cognitive status...
March 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28116913/roles-of-communication-problems-and-communication-strategies-on-resident-related-role-demand-and-role-satisfaction
#19
Marie Y Savundranayagam, Christopher Lee
This study investigated the impact of dementia-related communication difficulties and communication strategies used by staff on resident-related indicators of role demand and role satisfaction. Formal/paid long-term care staff caregivers (N = 109) of residents with dementia completed questionnaires on dementia-related communication difficulties, communication strategies, role demand (ie, residents make unreasonable demands), and role satisfaction (measured by relationship closeness and influence over residents)...
March 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28116912/tool-for-screening-visual-acuity-in-older-individuals-with-dementia
#20
Hélène Kergoat, Caroline Law, Estefania Chriqui, Bernard-Simon Leclerc, Marie-Jeanne Kergoat
Rationale/Objective: To develop a screening and referral algorithm tool to help identify which older institutionalized individuals with dementia need an eye examination. METHODS: The visual acuity (VA) screening test was developed on an iPad retina display. Three optotypes were used (letters, numbers, and tumbling E's) to determine whether one works best with dementia. The screening VA results and algorithm decision were validated against those obtained by an optometrist performing a complete eye examination...
March 2017: American Journal of Alzheimer's Disease and Other Dementias
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