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American Journal of Alzheimer's Disease and Other Dementias

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https://www.readbyqxmd.com/read/28116912/tool-for-screening-visual-acuity-in-older-individuals-with-dementia
#1
Hélène Kergoat, Caroline Law, Estefania Chriqui, Bernard-Simon Leclerc, Marie-Jeanne Kergoat
: Rationale/Objective: To develop a screening and referral algorithm tool to help identify which older institutionalized individuals with dementia need an eye examination. METHODS: The visual acuity (VA) screening test was developed on an iPad retina display. Three optotypes were used (letters, numbers, and tumbling E's) to determine whether one works best with dementia. The screening VA results and algorithm decision were validated against those obtained by an optometrist performing a complete eye examination...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28084096/marital-status-and-persons-with-dementia-in-assisted-living
#2
Noelle L Fields, Virginia E Richardson, Donna Schuman
Despite the prevalence of dementia among residents in assisted living (AL), few researchers have focused on the length of stay (LOS) in AL among this population. Little is known about the factors that may contribute to LOS in these settings, particularly for residents with dementia. In the current study, a sub-set of AL residents with dementia (n = 112) was utilized to examine whether marital status was associated with LOS in AL as this has received sparse attention in previous research despite studies suggesting that marital status influences LOS in other health-care and long-term care settings...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28084087/in-vivo-effect-of-a-5-ht7-receptor-agonist-on-5-ht-neurons-and-gaba-interneurons-in-the-dorsal-raphe-nuclei-of-sham-and-pd-rats
#3
Shuang Wang, Yan Zhao, Jie Gao, Yufang Guo, Xiang Wang, Jian Huo, Ping Wei, Jian Cao
The 5-hydroxytryptamine (5-HT; serotonin) neurotransmission is severely affected by the degeneration of nigrostriatal dopaminergic neurons. Here, we report the effects of the systemic administration of the 5-HT7 receptor agonist AS-19. In sham rats, the mean response of the 5-HT neurons in the dorsal raphe nucleus (DRN) to systemic AS-19 was excitatory and the mean response of the γ-aminobutyric acid (GABA) interneurons was inhibitory. In Parkinson disease (PD) rats, the same dose did not affect the 5-HT neurons and only high doses (640 μg/kg intravenous) were able to the increase GABA interneuron activity...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28191798/diagnostic-validity-comparison-between-criteria-based-on-csf-alzheimer-s-disease-biomarkers
#4
Maria Empar Blanco-Cantó, J A Monge-Argilés, C Pérez-Cejuela, C Badía, L Gabaldón, C Muñoz-Ruíz, J Sánchez-Payá, R Gasparini-Berenguer, C Leiva-Santana
AIM: To compare the diagnostic validity of NIA-AA criteria, for AD CSF biomarkers, with our own new criteria. MATERIALS AND METHODS: Between 2008 and 2011, 170 patients with Mild Cognitive Impairment (MCI) were included. CSF levels of Aβ1-42, T-tau, P-tau181, and ratios of T-tau/Aβ1-42 and P-tau181/Aβ1-42 were analyzed. In our criteria, we considered 3 or more abnormal variables indicative of a high likelihood of MCI due to AD. RESULTS: After a clinical follow-up of 4...
March 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28116927/the-relationship-between-what-we-believe-and-how-we-care-among-daughters-caring-for-a-parent-with-dementia
#5
Cory K Chen, Karima Clayton, Joshua Chodosh
This study attempted to better understand factors associated with relationship conflict between daughters and their parents with dementia. We examined data from 77 daughters self-identified as primary caregivers of a parent with dementia to test the hypothesis that daughters' belief that a parent with dementia can control their symptoms is associated with more conflict, defined as high expressed emotion (EE). Participants completed self-report questionnaires assessing beliefs about parents' ability to control symptoms, stress, relationship conflict, parent agitation, and cognitive status...
March 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28116913/roles-of-communication-problems-and-communication-strategies-on-resident-related-role-demand-and-role-satisfaction
#6
Marie Y Savundranayagam, Christopher Lee
This study investigated the impact of dementia-related communication difficulties and communication strategies used by staff on resident-related indicators of role demand and role satisfaction. Formal/paid long-term care staff caregivers (N = 109) of residents with dementia completed questionnaires on dementia-related communication difficulties, communication strategies, role demand (ie, residents make unreasonable demands), and role satisfaction (measured by relationship closeness and influence over residents)...
March 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28100077/effects-of-m2000-d-mannuronic-acid-on-learning-memory-retrieval-and-associated-determinants-in-a-rat-model-of-alzheimer-s-disease
#7
Somayeh Athari Nik Azm, Mohammadreza Vafa, Mohammad Sharifzadeh, Majid Safa, Anis Barati, Abbas Mirshafiey
The d-mannuronic acid (M2000) is a novel nonsteroidal anti-inflammatory drug that has immunosuppressive effects together with antioxidant property. M2000 has shown a notable efficacy in experimental models of multiple sclerosis, rheumatoid arthritis, and nephrotic syndrome. In this work, the effect of M2000 on the treatment of Alzheimer's disease (AD) was performed by Morris water maze experiment, and the immunological assessments were carried out by Western blot, apoptosis (procaspase-3, Bax/Bcl2, P53), enzymatic (superoxide dismutase [SOD]), and nonenzymatic oxidative stress (malondialdehyde [MDA]) tests...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28100076/precuneus-structure-changes-in-amnestic-mild-cognitive-impairment
#8
Robert Haussmann, Annett Werner, Antonia Gruschwitz, Antje Osterrath, Jan Lange, Katharina L Donix, Jennifer Linn, Markus Donix
Patients with amnestic mild cognitive impairment (aMCI) are at risk for developing Alzheimer's disease. Due to their prominent memory impairment, structural magnetic resonance imaging (MRI) often focuses on the hippocampal region. However, recent positron-emission tomography data suggest that within a network of frontal and temporal changes, patients with aMCI show metabolic alterations in the precuneus, a key region for higher cognitive functions. Using high-resolution MRI and whole-brain cortical thickness analyses in 28 patients with aMCI and 25 healthy individuals, we wanted to investigate whether structural changes in the precuneus would be associated with cortical thickness reductions in frontal and temporal brain regions in patients with aMCI...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28100075/urinary-incontinence-in-alzheimer-s-disease
#9
Hsiang-Ying Lee, Ching-Chia Li, Yung-Shun Juan, Yu-Han Chang, Hsin-Chih Yeh, Chia-Chun Tsai, Kuang-Shun Chueh, Wen-Jeng Wu, Yuan-Han Yang
OBJECTIVES: Urinary incontinence (UI) is more prevalent in the elderly populations with dementia than without dementia, and Alzheimer's disease (AD) is the most common cause of dementia. Urinary incontinence may complicate AD morbidity and mortality. Therefore, this study aimed to evaluate the prevalence and annual incidence and determine the risk possibility of UI, which is the main type of incontinence in patients with AD in Taiwan. METHODS: A total of 933 patients with AD were included in the study cohort, and a total of 2799 patients without AD by 1:3 proportion compared to the study cohort were used as a matched cohort...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28084078/association-of-gwas-top-genes-with-late-onset-alzheimer-s-disease-in-colombian-population
#10
Diana Jennifer Moreno, Susana Ruiz, Ángela Ríos, Francisco Lopera, Henry Ostos, Marc Via, Gabriel Bedoya
OBJECTIVE: The association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer's disease (LOAD) was evaluated and confirmed through genome-wide association study. However, it is unknown whether these associations can be replicated in admixed populations. METHODS: The association of 14 single-nucleotide polymorphisms in those genes was evaluated in 280 LOAD cases and 357 controls from the Colombian population. RESULTS: In a multivariate analysis using age, gender, APOE∊4 status, and admixture covariates, significant associations were obtained ( P < ...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27909150/validity-of-the-georgian-montreal-cognitive-assessment-for-the-screening-of-mild-cognitive-impairment-and-dementia
#11
Marina Janelidze, Nina Mikeladze, Nazibrola Bochorishvili, Ann Dzagnidze, Mariam Kapianidze, Nino Mikava, Irene Khatiashvili, Darejan Kakhiani, Ekaterina Mirvelashvili, Nino Shiukashvili, Zurab Nadareishvili
Montreal Cognitive Assessment (MoCA) test has been shown to be a reliable tool to detect mild cognitive impairment (MCI), however, no Georgian language version exists. The goal of this study is to determine the validity, reliability, and accuracy of Georgian version of MoCA in the evaluation of amnestic MCI (aMCI) and Alzheimer's disease (AD). Montreal Cognitive Assessment was translated into Georgian language and was administered to healthy participants (HP) and patients with aMCI and AD. We studied 46 HS, 20 patients with aMCI, and 20 patients with AD...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27899433/can-we-help-care-providers-communicate-more-effectively-with-persons-having-dementia-living-in-long-term-care-homes
#12
Katherine S McGilton, Elizabeth Rochon, Souraya Sidani, Alexander Shaw, Boaz M Ben-David, Marianne Saragosa, Veronique M Boscart, Rozanne Wilson, Karmit K Galimidi-Epstein, M Kathleen Pichora-Fuller
BACKGROUND: Effective communication between residents with dementia and care providers in long-term care homes (LTCHs) is essential to resident-centered care. PURPOSE: To determine the effects of a communication intervention on residents' quality of life (QOL) and care, as well as care providers' perceived knowledge, mood, and burden. METHOD: The intervention included (1) individualized communication plans, (2) a dementia care workshop, and (3) a care provider support system...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27899432/alz-i-connect
#13
Babak Tousi, Cheryl Kanetsky, Nancy Udelson
Currently, there is not enough time or staff in the physician's office to provide education about Alzheimer's disease for newly diagnosed patients and their family members. The Alzheimer's Association Cleveland Area Chapter has implemented a novel approach for individuals to connect to helpful information about Alzheimer's disease and related dementias while at the physician's office. This project is being piloted at two memory assessment clinics of The Cleveland Clinic as a way to give assessment center staff the opportunity to connect families right away with the free support services available at the Association...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27831477/living-alone-with-cognitive-impairment
#14
Allison K Gibson, Virginia E Richardson
Although most individuals experiencing cognitive impairment (CI) reside with a caregiver, an estimated 800,000 live alone. Such individuals may have an increased risk for injury to self or others through self-neglect as a result of the CI symptoms. While persons living alone with CI have been identified as an important area for needed research, few studies have been able to examine this population due to the challenges of identifying and recruiting study participants. By using the National Health & Aging Trends Study data set, the researchers explored the characteristics to describe this population...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27821563/a-nationwide-study-of-the-impact-of-dysphagia-on-hospital-outcomes-among-patients-with-dementia
#15
Suchitra Paranji, Neethi Paranji, Scott Wright, Shalini Chandra
OBJECTIVES: To assess the impact of dysphagia on clinical and operational outcomes in hospitalized patients with dementia. DESIGN: Retrospective cohort study. SETTING: 2012 Nationwide Inpatient Sample. PARTICIPANTS: All patients discharged with a diagnosis of dementia (N = 234,006) from US hospitals in 2012. MEASUREMENTS: Univariate and multivariate regression models, adjusting for stroke and patient characteristics, to assess the impact of dysphagia on the prevalence of comorbidities, including pneumonia, sepsis, and malnutrition; complications, including mechanical ventilation and death; and operational outcomes, including length of stay (LOS) and total charges for patients with dementia...
February 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27765867/risk-of-cognitive-decline-associated-with-paroxetine-use-in-elderly-nursing-home-patients-with-depression
#16
Vishal Bali, Satabdi Chatterjee, Michael L Johnson, Hua Chen, Ryan M Carnahan, Rajender R Aparasu
OBJECTIVE: This study evaluated the risk of cognitive decline associated with paroxetine use in elderly nursing home patients with depression. METHODS: A retrospective cohort study was conducted using the 2007 to 2010 Medicare Part D claims and minimum data set (MDS) data involving new users of paroxetine and other selective serotonin reuptake inhibitors (SSRIs). The primary outcome was MDS Cognition Scale. The repeated-measures mixed model was used to examine the effect of paroxetine on cognition after controlling for other factors...
December 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27659393/optimal-cutoff-scores-for-alzheimer-s-disease-using-the-chinese-version-of-mini-mental-state-examination-among-chinese-population-living-in-rural-areas
#17
Zhao Yang, Hunter K Holt, Jin-Hu Fan, Li Ma, Ying Liu, Wen Chen, Peter Como, Lin Zhang, You-Lin Qiao
To explore the optimal cutoff score for initial detection of Alzheimer's Disease (AD) through the Chinese version of Mini-Mental State Examination (CMMSE) in rural areas in China, we conducted a cross-sectional study within the Linxian General Population Nutritional Follow-up study. 16,488 eligible cohort members participated in the survey and 881 completed the CMMSE. Among 881 participants, the median age (Interquartile range) was 69.00 (10.00), 634 (71.92%) were female, 657 (74.57%) were illiterate, 35 (3...
December 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27574337/predictors-of-cognitive-decline-in-a-rural-and-remote-saskatchewan-population-with-alzheimer-s-disease
#18
Drew Hager, Andrew Kirk, Debra G Morgan, Chandima Karunanayake, Megan E O'Connell
To determine the predictors of cognitive decline in a rural and remote population with Alzheimer's disease (AD), we examined the association between cognitive change and sociodemographic, clinical, and functional data at the initial day of diagnosis. Simple linear regression analysis and multiple regression analysis were used to determine the predictors of cognitive decline as measured by the difference in the Mini-Mental State Examination over 1 year. Our sample included 72 patients with AD. Age at the clinic day appointment was 75...
December 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27609932/pilot-testing-of-the-eit-4-bpsd-intervention
#19
Barbara Resnick, Ann Kolanowski, Kimberly Van Haitsma, Marie Boltz, Elizabeth Galik, Alice Bonner, Erin Vigne, Lauren Holtzman, Paula M Mulhall
Behavioral and psychological symptoms of dementia are common in nursing home residents, and the Centers for Medicare and Medicaid Services now require that nonpharmacological interventions be used as a first-line treatment. Few staff know how to implement these interventions. The purpose of this study was to pilot test an implementation strategy, Evidence Integration Triangle for Behavioral and Psychological Symptoms of Dementia (EIT-4-BPSD), which was developed to help staff integrate behavioral interventions into routine care...
November 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27585748/effects-of-acetylcholinesterase-inhibitors-on-balance-and-gait-functions-and-orthostatic-hypotension-in-elderly-patients-with-alzheimer-disease
#20
Ahmet Turan Isik, Pinar Soysal, Cansu Usarel
OBJECTIVE: The present study was designed to evaluate the effect of acetylcholinesterase inhibitor (AchEI) therapy on balance, gait, and orthostatic hypotension (OH) in elderly patients with Alzheimer's disease (AD). METHODS: A total of 102 elderly patients with AD have been recently diagnosed and were treated with AchEI and underwent comprehensive geriatric assessment at baseline and at the end of the sixth month. RESULTS: Timed Up and Go test and Tinetti Performance-Oriented Mobility Assessment values and the prevalence of OH were not different at the end of the sixth month versus baseline (P > ...
November 2016: American Journal of Alzheimer's Disease and Other Dementias
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