journal
https://read.qxmd.com/read/31818446/lipoprotein-apheresis-in-germany-still-more-commonly-indicated-than-implemented-how-can-patients-in-need-access-therapy
#21
JOURNAL ARTICLE
Franz Heigl, Tobias Pflederer, Reinhard Klingel, Reinhard Hettich, Norbert Lotz, Harduin Reeg, Volker J J Schettler, Eberhard Roeseler, Peter Grützmacher, Bernd Hohenstein, Ulrich Julius
BACKGROUND: Although lipid-lowering drugs, especially statins, and recently also PCSK9 inhibitors can reduce LDL cholesterol (LDL-C) and decrease the risk for cardiovascular disease (CVD) including coronary artery disease (CAD) events most efficiently, only 5-10% of high-risk cardiovascular patients reach the target values recommended by international guidelines. In patients who cannot be treated adequately by drugs it is possible to reduce increased LDL-C and/or lipoprotein(a) (Lp(a)) values by the use of lipoprotein apheresis (LA) with the potential to decrease severe CVD events in the range of 70%->80%...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818445/lipoprotein-a-marker-for-cardiovascular-risk-and-target-for-lipoprotein-apheresis
#22
JOURNAL ARTICLE
Reinhard Klingel, Franz Heigl, Volker Schettler, Eberhard Roeseler, Peter Grützmacher, Bernd Hohenstein, Anja Vogt, Cordula Fassbender, Andreas Heibges, Ulrich Julius
Lipoprotein(a) (Lp(a)) consists of an LDL particle whose apolipoprotein B (apoB) is covalently bound to apolipoprotein(a) (apo[a]). An increased Lp(a) concentration is a causal, independent risk factor for atherosclerotic cardiovascular disease (ASCVD) and a predictor of incident or recurrent cardiovascular events. Although Lp(a) was first described as early as 1963, only the more recent results of epidemiological, molecular, and genetic studies have led to this unequivocal conclusion. More than 20% of Western populations have elevated Lp(a) values...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818444/lipoprotein-apheresis-shortening-of-treatment-intervals-reduces-cardiovascular-events-case-reports
#23
JOURNAL ARTICLE
Theresa Berent, Robert Berent, Helmut Sinzinger
BACKGROUND: Lipoprotein (Lp-) apheresis is a life-long therapy, usually performed in weekly intervals. In some cases, however, atherosclerotic disease progresses despite adequate therapy with weekly Lp-apheresis and maximal lipid lowering medication. In an attempt to improve the effectiveness of therapy, we temporarily shortened treatment intervals of Lp-apheresis in patients with elevated lipoprotein(a) (Lp(a)) and further progression of coronary atherosclerosis despite weekly Lp-apheresis and maximal lipid lowering medication...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818443/homozygous-familial-hypercholesterolaemia-in-childhood-the-first-case-report-in-southeast-europe
#24
JOURNAL ARTICLE
Bojko Bjelakovic, Claudia Stefanutti, Livia Pisciotta, Gerald Watts, Ramush Bejiqi
Homozygous familial hypercholesterolaemia (HoFH) is the rare, severe, but treatable disease characterised by exceedingly high levels of low-density lipoprotein cholesterol (LDL-C) and subsequent premature coronary heart disease. Of note, HoFH detection rate and patient access to healthcare and treatment modalities still differ considerably across EU countries. To our current knowledge, there are still no published reports describing HoFH in the paediatric population of Southeastern Europe. In this case report, a few important topics on obstacles in getting adequate health care service and management of HoFH children from Southeastern Europe are tackled...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818442/influence-of-lipoprotein-apheresis-on-circulating-plasma-levels-of-mirnas-in-patients-with-high-lp-a
#25
JOURNAL ARTICLE
Dana Dlouha, Iveta Prochazkova, Zuzana Eretova, Jaroslav A Hubacek, Alena Parikova, Jan Pitha
BACKGROUND: Lipoprotein apheresis (LA) is a well-established therapy for lowering lipid levels in serious cases of dyslipidaemia, including high levels of lipoprotein(a) [Lp(a)]. This method lowers both LDL cholesterol and Lp(a) by more than 60% in most of patients; however, because randomized clinical studies could be extremely difficult, also other markers of the effect of this procedures on vascular health are of importance. Therefore, in addition to changes in plasma lipids and Lp(a) during LA, we also analysed the response of biomarkers associated with vascular integrity: small non-coding microRNAs (miRNAs)...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818441/a-successful-term-pregnancy-with-severe-hypertriglyceridaemia-and-acute-pancreatitis-clinical-management-and-review-of-the-literature
#26
JOURNAL ARTICLE
Seila Perrone, Roberto Brunelli, Giuseppina Perrone, Ilaria Zannini, Paola Galoppi, Serafina Di Giacomo, Claudia Morozzi, Livia Pisciotta, Claudia Stefanutti
BACKGROUND AND AIMS: Acute hyperlipidaemic pancreatitis (HP) may develop in pregnancy in patients with genetic predisposition. There are no accepted guidelines for the management of this rare but life-threatening condition in pregnancy. Plasma exchange (PEX) was suggested as a suitable option to treat HP in pregnancy; however, further evidence from case reports/case series are needed. METHODS: Three PEX procedures (2000 ml of plasma replaced with 5% albumin) were performed in one week in a pregnant patient at 25 weeks of gestational age with severe HP...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818440/a-complicated-pregnancy-in-homozygous-familial-hypercholesterolaemia-treated-with-lipoprotein-apheresis-a-case-report
#27
JOURNAL ARTICLE
Seila Perrone, Giuseppina Perrone, Roberto Brunelli, Serafina Di Giacomo, Paola Galoppi, Guendalina Flammini, Claudia Morozzi, Claudia Stefanutti
BACKGROUND AND AIMS: During pregnancy total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels increase significantly and lipoprotein apheresis (LA) is considered the most effective therapy in homozygous familial hypercholesterolaemia (HoFH) for modulating lipid and lipoprotein levels and reducing maternal and foetal complications. CLINICAL CASE: A primigravida 28 years old Caucasian female patient, previously diagnosed as to be HoFH, was admitted at our outpatient service at the beginning of pregnancy...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818439/kidney-and-liver-are-the-main-organs-of-expression-of-a-key-metabolic-enzyme-alanine-glyoxylate-aminotransferase-2-in-humans
#28
JOURNAL ARTICLE
Natalia Jarzebska, Sophia Georgi, Normund Jabs, Silke Brilloff, Renke Maas, Roman N Rodionov, Christian Zietz, Sabrina Montresor, Bernd Hohenstein, Norbert Weiss
BACKGROUND: The metabolic syndrome is a cluster of cardiovascular risk factors and is highly predictive for development of cardiovascular diseases. An association between elevated plasma levels of the endogenous inhibitor of nitric oxide synthases asymmetric dimethylarginine (ADMA) and risk of cardiovascular diseases has been demonstrated in numerous epidemiological studies. ADMA can be catabolized by dimethylarginine dimethylaminohydrolase (DDAH) or metabolized through a much less understood alternative pathway by alanine:glyoxylate aminotransferase 2 (AGXT2) with the formation of α-keto-δ-(N,N-dimethylguanidino)valeric acid (ADGV)...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818438/adma-elevation-does-not-exacerbate-development-of-diabetic-nephropathy-in-mice-with-streptozotocin-induced-diabetes-mellitus
#29
JOURNAL ARTICLE
Roman N Rodionov, Natalia Jarzebska, Alfred Schneider, Annett Rexin, Jan Sradnick, Silke Brilloff, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Vladimir Todorov, Christian Hugo, Norbert Weiss, Bernd Hohenstein
BACKGROUND AND AIMS: Cardiovascular disease is nowadays the major cause of mortality and morbidity worldwide. The risk of developing cardiovascular disease is significantly increased in patients with diabetic nephropathy. It has been suggested that asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthases (NOS), may play an important role in the pathogenesis of diabetic nephropathy. ADMA is mainly metabolized by dimethylarginine dimethylaminohydrolase 1 (DDAH1). The goal of this study was to test the hypothesis that elevation of systemic ADMA levels by knocking out DDAH1 would exacerbate functional and structural glomerular abnormalities in a murine model of diabetic nephropathy...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31818437/actual-situation-of-lipoprotein-apheresis-in-patients-with-elevated-lipoprotein-a-levels
#30
JOURNAL ARTICLE
Ulrich Julius, Sergey Tselmin, Ulrike Schatz, Sabine Fischer, Andreas L Birkenfeld, Stefan R Bornstein
An elevation of lipoprotein(a) (Lp(a)) is an internationally recognized atherogenic risk factor, documented in epidemiological studies, in studies with Mendelian randomization and in genome-wide association studies (GWAS). At present, no drug is available to effectively reduce its concentration. In Germany, an elevation of Lp(a) associated with progressive cardiovascular diseases is officially recognized as an indication for a lipoprotein apheresis (LA). The number of patients who were treated with LA with this abnormality was steadily increasing in the years 2013-2016 - the official data are reported...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31447217/immunoadsorption-in-nephrotic-syndrome-where-are-we-now-and-where-are-we-going-from-here
#31
REVIEW
Andreas Kronbichler, Philipp Gauckler, Keum Hwa Lee, Jae Il Shin, Paolo Malvezzi, Gert Mayer
Idiopathic nephrotic syndrome (INS) is characterized by three different entities, namely minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) and membranous nephropathy (MN). While there is an increasing understanding of primary MN with the discovery of antibodies directed against phospholipase A2 receptor (PLA2R Ab) and thrombospondin type 1 domain-containing 7A, circulatory factors causative of inducing MCD and FSGS remain in part elusive. Extracorporeal treatment forms (mostly plasma exchange) have been reserved for patients with either a disease course refractory to commonly prescribed immunosuppressive drugs or to patients with recurrence after kidney transplantation...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31447216/statin-induced-muscular-side-effects-at-rest-and-exercise-an-anatomical-mapping
#32
JOURNAL ARTICLE
Theresa Berent, Robert Berent, Sabine Steiner, Helmut Sinzinger
BACKGROUND AND AIMS: Muscle-related symptoms with or without creatine kinase (CK) elevation are common adverse effects associated with statin use. Symptoms are ranging from benign myalgia to myositis and in rare cases to rhabdomyolysis. The aim was to characterize and describe muscular side effects and create an anatomical frequency mapping. METHODS: The prospective observational study was performed at a large lipidology outpatient unit in Vienna. 1111 consecutively admitted patients with muscular side effects on statin monotherapy were included during a 4-year period...
December 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31451336/the-role-of-red-yeast-rice-ryr-supplementation-in-plasma-cholesterol-control-a-review-and-expert-opinion
#33
JOURNAL ARTICLE
Maciej Banach, Eric Bruckert, Olivier S Descamps, Lars Ellegård, Marat Ezhov, Bernhard Föger, Zlatko Fras, Petri T Kovanen, Gustavs Latkovskis, Winfried März, Demosthenes B Panagiotakos, György Paragh, Daniel Pella, Angela Pirillo, Andrea Poli, Željko Reiner, Günter Silbernagel, Margus Viigimaa, Michal Vrablík, Alberico L Catapano
No abstract text is available yet for this article.
August 17, 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/31447215/effectiveness-of-different-immunoadsorption-columns-for-anti-a-b-antibody-depletion
#34
JOURNAL ARTICLE
Claudius Speer, Florian Kälble, Luiza Pego da Silva, Christian Nusshag, Matthias Schaier, Luis E Becker, Katrin Klein, Jörg Beimler, Claudia Sommerer, Albrecht Leo, Caner Süsal, Arianeb Mehrabi, Martin Zeier, Christian Morath
OBJECTIVE: In recent studies, semi-selective compared to antigen-specific immunoadsorption (IA) columns showed comparable effectiveness in anti-A/B antibody removal before incompatible living donor kidney transplantation. Semi-selective columns allow a greater number of IA treatments at lower costs. They are also capable of removing potentially harmful human leukocyte antigen alloantibodies. Nevertheless, additional plasma exchange treatments are often necessary to reach the preoperative target titer, most likely due to an inadequate anti-A/B IgM antibody depletion...
August 17, 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876532/achilles-tendon-ultrasonography-a-useful-screening-tool-for-cardiovascular-risk-estimation-in-patients-with-severe-hypercholesterolemia
#35
JOURNAL ARTICLE
Sandra Kutkienė, Žaneta Petrulionienė, Aleksandras Laucevičius, Rimantė Čerkauskienė, Artūras Samuilis, Virginija Augaitienė, Aurelija Gedminaitė, Gintarė Bieliauskienė, Akvilė Šaulytė-Mikulskienė, Justina Staigytė, Emilija Petrulionytė, Urtė Gargalskaitė, Eglė Skiauterytė, Gabija Matuzevičienė, Milda Kovaitė, Irena Nedzelskienė
BACKGROUND AND AIMS: Achilles tendon lesions have long been associated with genetic defects in lipid metabolism and increased risk of cardiovascular diseases (CVD). With this study we aimed to evaluate the usefulness of Achilles tendon ultrasonography in identifying people at greater risk among subjects with severe hypercholesterolemia (SH) in a high-risk population. METHODS: During the period of 2016-2017 a total of 213 participants were enrolled in this case-control study...
March 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876531/investigating-the-association-between-familial-hypercholesterolemia-and-perceived-depression
#36
JOURNAL ARTICLE
Nien-Tzu Chang, Ta-Chen Su
BACKGROUND AND AIMS: Inherited familial hypercholesterolemia (FH) increases cardiovascular risks, but perceived depression in FH is unknown. This study aims to explore the association between the FH and perceived depression. METHODS: This study was a hospital-based design, we started to recruit clinical diagnosis of phenotypic FH since 2014 for the Ten Countries Study in the Asia-Pacific region. We consecutively recruited 302 FH patients and other 414 comparison subjects (214 subjects with hypertriglyceridemia and 200 subjects with normal lipid controls) from the special lipid clinic of National Taiwan University Hospital, Taipei...
March 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876530/variable-expression-and-penetrance-in-portuguese-families-with-familial-hypercholesterolemia-with-mild-phenotype
#37
JOURNAL ARTICLE
I M Gaspar, A Gaspar
Familial hypercholesterolemia is an Mendelian dominant disorder characterized by defects of the low density lipoprotein receptor (LDLR) that result in a defective removal of LDL from plasma, which promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and arteries (atherosclerosis). Diagnosis severe clinical phenotype FH with Dutch Lipid Clinic Network Criteria, encompassing history of premature ASCVD, tendon xanthomas, and a family history of hypercholesterolemia and premature ASCVD in relatives is rare in the Portuguese FH patients...
March 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876529/establishing-a-familial-hypercholesterolaemia-register-the-first-year
#38
JOURNAL ARTICLE
Myra Tilney
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is an autosomal dominant condition raising the risk of premature cardiovascular disease up to twentyfold.[1] [2] It is under-diagnosed and undertreated, in spite of availability of effective treatment. Registers are recommended to assist in the recognition and improvement of the condition since treatment reduces morbidity and mortality. Disease registers enable longitudinal review and the application of continuous quality improvement methodology...
March 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876528/percutaneous-coronary-intervention-for-a-chinese-familial-hypercholesterolemia-homozygous-under-the-guidance-of-optical-coherence-tomography
#39
JOURNAL ARTICLE
Zesen Liu, Jie Peng, Shilong Wang, Tao Jiang, Weicong Zhang, Chun Zhang, Yan Chen, Kang Meng, Jie Lin
Homozygous familial hypercholesterolemia developed into severe cardiovascular consequences early. Untreated HoFH usually cannot survive over 30 years old. Acute coronary syndrome(ACS) caused by plaque rupture is one of the main causes of death in HoFH. As the highest resolution intravascular imaging technique, optical coherence tomography(OCT) can clearly show the thickness and structural characteristics of atherosclerotic plaque caps. In this study, a Chinese male HoFH received percutaneous coronary intervention for unstable angina...
March 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876527/familial-hypercholesterolemia-in-china-half-a-century-a-review-of-published-literature
#40
JOURNAL ARTICLE
Jie Peng, Xue Wu, Shilong Wang, Shuang Zhang, Xumin Wang, Zesen Liu, Jing Hong, Pucong Ye, Jie Lin
AIMS: To investigate the status of familial hypercholesterolemia (FH) research and the characteristics of patients with FH in China. METHODS: Published papers in Chinese or English language from PubMed, SinoMed and CNKI databases from 1971 to March 2018 were searched using 'Familial hypercholesterolemia', 'Chinese' and 'Han' as keywords. A systematic review of studies on familial hypercholesterolemia was then conducted. RESULTS: A total of 391 articles were found, in which 22% were in English and 78% were in Chinese; approximately 43% are case reports and 34% are genetic reports according to the study type; 52% discussed the status of the disease and 11% investigated the subclinical status according to the study content...
March 2019: Atherosclerosis. Supplements
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