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Clinical and Experimental Medicine

Zhao-Xia Li, Shan Zeng, Hui-Xia Wu, Yi Zhou
Previous systematic reviews have found a higher sero-prevalence of EBV antibodies in SLE patients compared with controls. Because many studies have been published, there is a need to apply more precise systematic review methods. We examined the association between EBV and SLE patients by conducting a systematic review and meta-analysis of case-control studies that examined the prevalence of EBV antibodies and the DNA-positive rate. We searched the MEDLINE and EMBASE databases from 1966 to 2018 with no language restrictions...
October 25, 2018: Clinical and Experimental Medicine
Jun-Chi Xu, Fei Gao, Yi-An Liu, Xiao-Long Zhang, Hui Chen, Xiao-Yan Zhu, Hua-Feng Song, Feng Qian, Ming Li, Chen Yang, Chuan-Wu Zhu, Ping Xu
This study analysed the biological significance of TLT-2 on CD8+ T cells in hepatitis B patients and provided a theoretical basis for the potential role of TLT-2 as an immune regulator. Flow cytometry sorting, isobaric tags for relative and absolute quantitation and short hairpin RNAs were used to analyse the function of TLT-2 on CD8+ T cells in hepatitis B patients. The TLT-2 expression levels in the acute hepatitis B and chronic hepatitis B groups were significantly higher than that in the healthy control group and were positively correlated with ALT and AST...
October 25, 2018: Clinical and Experimental Medicine
Katharina Kerschan-Schindl, Gerold Ebenbichler, Wolfgang Gruther, Ursula Föger-Samwald, Stefan Kudlacek, Janina Patsch, Andreas Gleiss, Peter Jaksch, Walter Klepetko, Peter Pietschmann
Recipients of lung transplantation (LuTx) may experience impaired muscle function and bone metabolism even after rehabilitation. We investigated the potential use of musculoskeletal markers in identifying the impairment of muscle function and bone function in these patients. Biochemical parameters, bodily functions, and lung function of 37 LuTx recipients were evaluated at the time of their discharge from the hospital stay and about 6 months later. The biomarkers were also assessed in 30 healthy age and gender distribution-matched controls...
October 13, 2018: Clinical and Experimental Medicine
Yaofu Liu, Huiling Li, Jianyi Dong, Lei Ma, Aijun Liao, Zhuona Rong, Zhi Zhou, Liang Cao, Fujin Wang, Jingyu Wang, Aiguo Wang
Deficiency of γ-glutamyl carboxylation of coagulation factors, as evidenced by the elevated level of Des-γ-carboxyl prothrombin (DCP), is a common feature in hepatocellular carcinoma patients. Additionally, treatment of cancer patients with mTOR inhibitors significantly increases hemorrhagic events. However, the underlying mechanisms remain unknown. In the present study, Vitamin K epoxide reductase complex subunit 1 (VKORC1) was found to be significantly down-regulated in clinical hepatoma tissues and most tested hepatoma cell lines...
October 10, 2018: Clinical and Experimental Medicine
Keiji Mashimo, Masanobu Tsubaki, Tomoya Takeda, Ryota Asano, Minami Jinushi, Motohiro Imano, Takao Satou, Katsuhiko Sakaguchi, Shozo Nishida
The survival and growth of multiple myeloma (MM) cells are facilitated by cell-cell interactions with bone marrow stromal cells and the bone marrow microenvironment. These interactions induce de novo drug resistance known as cell adhesion-mediated drug resistance. Our previous results recently revealed that the receptor activator of NF-κB (RANK) ligand (RANKL), which is expressed by bone marrow stromal cells, contributes to anti-cancer drug resistance through the activation of various signaling molecules and suppression of Bim expression in RANK-expressing MM cells...
October 5, 2018: Clinical and Experimental Medicine
Xiuzhen Wang, Chunshu Yang, Feng Xu, Lin Qi, Jianing Wang, Pingting Yang
Follicular helper T(Tfh) cells and follicular regulatory T(Tfr) cells are critical for the development and maintenance of germinal center and humoral immune responses. Accumulating evidence has demonstrated that the dysregulation of either Tfh or Tfr cells contributes to the pathogenesis of autoimmune diseases. The aim of this study was to examine the numbers of Tfh and Tfr cells in patients with rheumatoid arthritis (RA). Twenty-four patients with RA patients and 20 health controls (HCs) were enrolled in this study...
October 4, 2018: Clinical and Experimental Medicine
Yongjian Yue, Qing Sun, Chiwai Man, Yingyun Fu
Genome-wide association studies have identified the CYP4V2 polymorphism (rs13146272) as a risk factor associated with venous thromboembolism (VTE). However, due to the small sample size and variance in genetic analysis models, the relationship between VTE and rs13146272 remains unclear. Here, we performed a case-control study to analyse the associations between rs13146272 and VTE in a Chinese population and to compare the differences among various ethnicities. In this study, 226 VTE patients and 205 healthy controls were recruited, and the allele frequency of variant rs13146272 was analysed by a MassARRAY SNP genotyping assay...
October 1, 2018: Clinical and Experimental Medicine
Natividad Castro-Alarcón, Rubén Rodríguez-García, María Ruíz-Rosas, José Francisco Muñoz-Valle, Iris Paola Guzmán-Guzmán, Isela Parra-Rojas, Mirna Vázquez-Villamar
Escherichia coli is the main etiological agent of urinary tract infections. Its virulence factors are important during the initial interaction stage with the host as they enable colonization of urinary tract tissues. The genetic markers evidencing susceptibility to develop recurrent infections have been previously described. Toll-like receptors are critical sensors of microbial attacks, and they are also effectors of the individual's innate defense for elimination of pathogens. The aim of this study was to evaluate the association between functional polymorphisms (896 A>G, 1196 C>T, - 2570 A>G, - 2081 G>A) and susceptibility to develop urinary tract infections as well as E...
September 15, 2018: Clinical and Experimental Medicine
Azzah Alharbi, Jonathan P Thompson, Nicholas P Brindle, Cordula M Stover
Septicaemia is an acute inflammatory reaction in the bloodstream to the presence of pathogen-associated molecular patterns. Whole blood stimulation assays capture endotoxin-induced formation of aggregates between platelets and leucocytes using flow cytometry. We wanted to assess extent of spontaneous aggregate formation in whole blood stimulation assays and compare the effects of endotoxin and heat-killed, clinically relevant, bacterial pathogens on aggregate formation and then on adhesion of aggregates to TNFα-stimulated endothelial cells...
September 6, 2018: Clinical and Experimental Medicine
Ya Su, Siqi Feng, Li Luo, Ruixi Liu, Qijian Yi
The original version of this article unfortunately contained a mistake. The copyright line was incorrect in the HTML version.
August 31, 2018: Clinical and Experimental Medicine
Amira S Abo ElAtta, Yasser B M Ali, Iman H Bassyouni, Roba M Talaat
miRNAs are noncoding RNA that play a critical role as fine regulators of gene expression at the posttranscriptional level within cells in numerous autoimmune diseases. miR-221/222 play a role in cancer by regulating cell proliferation, invasion and apoptosis. However, there have been insufficient studies on their role in rheumatoid arthritis (RA). This work is designed to analyze the miR-221/222 expression patterns in peripheral blood mononuclear cells (PBMCs) of patients with RA in comparison with healthy controls using quantitative RT-PCR, in a group of 30 RA patients and 20 healthy controls...
August 21, 2018: Clinical and Experimental Medicine
Martino Pepe, Annagrazia Cecere, Pasquale D'Alessandro, Fabrizio Fumarola, Marco Matteo Ciccone, Alfredo Marchese, Andrea Igoren Guaricci, Arturo Giordano, Alessandro Santo Bortone, Stefano Favale
Inflammatory bowel diseases have been recognized as predisposing factors to atherosclerosis and thrombotic events, involving both the venous and the arterial circulatory systems. We report the case of a 70-year-old man who presented with ST elevation myocardial infarction during the active phase of ulcerative colitis (UC). Because of the ongoing hematochezia, after successful revascularization of the culprit vessel, the patient was medicated with Clopidogrel, in place of one of the more powerful new oral P2Y12 inhibitors that currently represent the gold standard therapy...
November 2018: Clinical and Experimental Medicine
Nahla E El-Ashmawy, Enas A El-Zamarany, Eman G Khedr, Hoda A El-Bahrawy, Ola A El-Feky
Hepatocellular carcinoma (HCC) is one of the major health problems in the world. DCs-based vaccines are a promising immunotherapeutic strategy that aims at the optimal for induction of a specific antitumor immune response and destruction of tumor cells. The present study was conducted to investigate the immunogenic characters of whole tumor lysate-pulsed DCs vaccine and its ability to induce a specific antitumor immune response in HCC mice model. We also evaluate the effectiveness of prophylactic and therapeutic immunization strategies against HCC in mice models...
November 2018: Clinical and Experimental Medicine
Xia Wang, Peilin Zheng, Gan Huang, Lin Yang, Zhiguang Zhou
Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute a novel class of anti-diabetic agents confirmed to improve glycemic control and preserve β-cell function in type 2 diabetes. Three major large-scale studies, EXAMINE, SAVOR-TIMI 53, and TECOS, have confirmed the cardiovascular safety profile of DPP-4 inhibitors. Based on these results, DPP-4 inhibitors have gained widespread use in type 2 diabetes treatment. It is currently unknown, however, whether DPP-4 inhibitors have similar therapeutic efficacy against autoimmune diabetes...
November 2018: Clinical and Experimental Medicine
Behzad Poopak, Adnan Khosravi, Gholamreza Bahoush-Mehdiabadi, Tahereh Madani, Elahe Khodadi, Zohreh Farahani, Amir Ali Vahedi, Gelareh Khosravipour, Peyvand Poopak, Amir Hossein Poopak
Mixed-phenotype acute leukemia (MPAL) is the infrequent type of acute leukemia characterized by immunophenotypic and/or cytochemical features of both lineages, but the diagnosis of this disease still is a challenge. In this study, we analyzed immunophenotyping, cytochemistry and frequency of MPAL patients to better diagnosis of MPAL characteristics according to WHO 2016 criteria for the first time in Iran. In this retrospective study, 27 patients were diagnosed as MPAL based on WHO 2016 criteria during 2014-2017...
November 2018: Clinical and Experimental Medicine
Kotaro Matsuda, Hiroaki Miyoshi, Koji Hiraoka, Tetsuya Hamada, Shiro Yoshida, Yukinao Ishibashi, Toshiaki Haraguchi, Naoto Shiba, Koichi Ohshima
The etiology of rheumatoid arthritis (RA) is thought to involve dysfunction of the programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) pathway; PD-1 negatively regulates autoimmunity by interacting with its ligand, PD-L1. We therefore investigated PD-1/PD-L1 expression in synovial tissue of patients with RA. We immunohistochemically stained synovial specimens from 51 patients with RA and assessed the association between PD-1/PD-L1 expression and rheumatoid factor (RF), the total count of infiltrating T cells, C-reactive protein (CRP), and Krenn's synovitis score...
November 2018: Clinical and Experimental Medicine
Leonardo Spatola, Elena Generali, Claudio Angelini, Salvatore Badalamenti, Carlo Selmi
Type II mixed cryoglobulinemia without evidence of HCV infection but rather with renal involvement has been occasionally described. The pathogenesis of cryoglobulinemic kidney disease is most likely related to immune complex deposition including cryoglobulins, and cryoaggregation after cold exposure could play a pivotal role in clinical expression of cryoglobulinemia. In these cases, acute kidney injury and proteinuria remain the most frequent clinical expression of a cryoglobulinemic glomerulonephritis. Type II cryoglobulinemia with the laboratory finding of both monoclonal and polyclonal cryoglobulins is the most prevalent bio-humoral pattern among HCV-negative phenotypes with renal involvement, while type III cryoglobulinemia with polyclonal Ig is rare...
November 2018: Clinical and Experimental Medicine
Venkata Krishna Vamsi Gade, Archana Mony, Malathi Munisamy, Laxmisha Chandrashekar, Medha Rajappa
Alopecia areata (AA) is a type of non-scarring, recurrent patchy loss of hair in hair-bearing areas and is mostly of autoimmune origin. Previous studies have suggested that some autoimmune diseases were found to be associated with vitamin D deficiency. The current study was designed to assess the levels of serum 25-hydroxy vitamin D and C-reactive protein in AA, as compared with controls and to further identify the association between vitamin D levels and disease severity in patients with AA. This cross-sectional study included 45 patients with AA and 45 healthy volunteers...
November 2018: Clinical and Experimental Medicine
Jie Lin, Yihui He, Lingfeng Chen, Xiaoyan Chen, Shengbing Zang, Wansong Lin
Myosin light chain kinase (MYLK) is found to catalyze the phosphorylation of myosin light chains (MLC) and regulate invasion and metastasis in some malignancies. However, there is little knowledge on the role of MYLK in hepatocellular carcinoma (HCC), and no studies have been conducted to investigate the mechanisms underlying MYLK-mediated promotion of HCC invasion and metastasis until now. In this study, we investigated the expression of MYLK in 50 pairs of human HCC and adjacent liver specimens. High MYLK expression was significantly correlated with aggressive clinicopathological features including tumor encapsulation, microvascular invasion and metastasis...
November 2018: Clinical and Experimental Medicine
Rosekeila Simões Nomelini, Luciano Eliziário Borges Júnior, Cid Almeida de Lima, Ana Flávia Carrijo Chiovato, Douglas Côbo Micheli, Beatriz Martins Tavares-Murta, Eddie Fernando Candido Murta
The aims of the study were to compare the levels of tumor necrosis factor alpha (TNF-α) and its soluble type I (sTNF-R1) and type II (sTNF-R2) receptors detected in intracystic liquid and serum from benign and malignant ovarian neoplasms and to relate them to prognostic factors in epithelial ovarian cancer. The patients were divided into benign ovarian neoplasms (n = 46) and malignant ovarian neoplasms (n = 17). The serum and intracystic samples were collected before and during surgery for ovarian cyst, respectively...
November 2018: Clinical and Experimental Medicine
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