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Clinical and Experimental Medicine

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https://www.readbyqxmd.com/read/29777390/synergistic-effect-of-trail-and-irradiation-in-elimination-of-glioblastoma-stem-like-cells
#1
Junfeng Liu, Qinglei Gao, Tao Xie, Yu Liu, Longjun Luo, Cheng Xu, Lu Shen, Feng Wan, Ting Lei, Fei Ye
Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as GBM stem-like cells (GSLCs) were supposed to be the most malignant cells among GBM cells as they are resistant to multiple therapies including radiotherapy. In this study, we set up two GSLCs cell lines from the two parental U87 and U251 glioma cell lines, and studied the expression of apoptosis-related genes alteration in GSLCs before and after irradiation. We found that one of the receptors of TNF-related apoptosis-inducing ligand (TRAIL), DR5, was dramatically up-regulated in GSLCs after irradiation (IR)...
May 18, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29749584/droplet-digital-pcr-detects-high-rate-of-tp53-r249s-mutants-in-cell-free-dna-of-middle-african-patients-with-hepatocellular-carcinoma
#2
Agnès Marchio, Marie Amougou Atsama, Aubin Béré, Narcisse-Patrice Komas, Dominique Noah Noah, Paul Jean Adrien Atangana, Serge-Magloire Camengo-Police, Richard Njouom, Claudine Bekondi, Pascal Pineau
Hepatocellular carcinoma (HCC) is still a major killing malignancy in sub-Saharan Africa. Lifelong intoxication with aflatoxin B1 is considered as one of the primary causes of this situation. The role of aflatoxin in HCC from a given population is commonly estimated through the prevalence of R249S mutation of TP53, a hallmark for previous exposure to the mycotoxin. However, the role of AFB1 is barely known in large part of Africa. We conducted a survey on circulating cell-free DNA from 149 patients with HCC and 213 control subjects with and without liver diseases from Cameroon and Central African Republic using droplet digital PCR technique...
May 10, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29744686/the-humoral-immunity-to-epidermal-and-dermal-antigens-in-psoriasis-a-downstream-rather-than-an-upstream-event
#3
LETTER
Leena Chularojanamontri, Chanisada Wongpraparut, Narumol Silpa-Archa, Paleerath Peerapen, Wanida Boonmark, Kanokvalai Kulthanan, Visith Thongboonkerd
No abstract text is available yet for this article.
May 10, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29696462/longitudinal-monitoring-of-liver-fibrosis-status-by-transient-elastography-in-chronic-hepatitis-b-patients-during-long-term-entecavir-treatment
#4
Sheng-Di Wu, Li-Li Liu, Ji-Lin Cheng, Yun Liu, Li-Sha Cheng, Si-Qi Wang, Wei Ma, Li-Ping Chen, Yu-Jen Tseng, Ji-Yao Wang, Xi-Zhong Shen, Wei Jiang
The correlation between improvement in longitudinal liver stiffness and fibrosis regression has not been properly evaluated during long-term antiviral therapy in chronic hepatitis B (CHB) patients. In this study, liver stiffness was serially performed by FibroScan® every 26 weeks in a prospective cohort of CHB patients receiving entecavir. Results were compared with liver biopsies at baseline and week 78. A total of 120 treatment-naïve CHB patients were analyzed, in which 54 (45%) patients had fibrosis regression at 78 weeks of antiviral therapy...
April 25, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29644482/metabolic-syndrome-and-the-decreased-levels-of-uric-acid-by-leflunomide-favor-redox-imbalance-in-patients-with-rheumatoid-arthritis
#5
Neide Tomimura Costa, Bruna Miglioranza Scavuzzi, Tatiana Mayumi Veiga Iriyoda, Marcell Alysson Batisti Lozovoy, Daniela Frizon Alfieri, Fabiano Aparecido de Medeiros, Marcelo Cândido de Sá, Pâmela Lonardoni Micheletti, Bruno Alexandre Sekiguchi, Edna Maria Vissoci Reiche, Michael Maes, Andréa Name Colado Simão, Isaias Dichi
Oxidative stress plays a role in the pathophysiology of rheumatoid arthritis (RA). The aim of the present study was to verify the influence of metabolic syndrome (MetS) and disease-modifying antirheumatic drugs on nitrosative and oxidative biomarkers in patients with RA. A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP)...
April 11, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29623491/the-complex-alteration-in-the-network-of-il-17-type-cytokines-in-patients-with-hereditary-angioedema
#6
Francesco Arcoleo, Mariangela Lo Pizzo, Gabriella Misiano, Salvatore Milano, Giuseppina Colonna Romano, Vito Muggeo, Enrico Cillari
Hereditary angioedema (HAE) is a rare autosomic-dominant disorder characterized by a deficiency of C1 esterase inhibitor which causes episodic swellings of subcutaneous tissues, bowel walls and upper airways that are disabling and potentially life-threatening. We evaluated n = 17 patients with confirmed HAE diagnosis during attack and remission state and n = 19 healthy subjects. The samples were tested for a panel of IL (Interleukin)-17-type cytokines (IL-1β, IL-6, IL-10, granulocyte-macrophage colony stimulating factor (GM-CSF), IL-17, IL-21, IL-22, IL-23) and transforming growth factor-beta (TGF-β) subtypes...
April 6, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29600337/mutations-in-smad-interacting-protein-1-gene-are-responsible-for-absence-of-its-expression-in-hirschsprung-s-disease
#7
Wei Zhao, Shu-Cheng Zhang, Wen-Kai Huang, Xue-Li Li
Hirschsprung's disease (HSCR) is a common congenital malformation of the enteric nervous system. The pathophysiological basis remains unclear. Recently, the SIP1 gene has been recognized as being involved in the pathogenesis of symptomatic HSCR patients with 2q22 chromosomal rearrangement. In this study, mutations in SIP1 were analyzed to explore the relationship between SIP1 and HSCR. All exons of SIP1 were amplified and then analyzed by PCR-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing...
March 29, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29572669/good-glycaemic-control-is-associated-with-a-better-prognosis-in-breast-cancer-patients-with-type-2-diabetes-mellitus
#8
Yen-Lin Chang, Wayne Huey-Herng Sheu, Shih-Yi Lin, Wen-Shyong Liou
Although diabetes mellitus (DM) is one of the risk factors associated with increased breast cancer (BC) mortality, the effects of glycaemic control on the prognosis of BC have not been thoroughly evaluated. This retrospective study aimed to evaluate the relationship between glycaemic control and BC prognosis and to determine an optimal target of glycaemic control for BC patients with diabetes. We included 2812 stage 0-3 BC women, of whom 145 were diabetic and were 2667 non-diabetic. In those with diabetes, a mean haemoglobin A1C (HbA1C) < 7% (n = 77) was defined as well-controlled diabetes, while a mean HbA1C > 9% (n = 16) was defined as poorly controlled diabetes...
March 23, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29550986/impact-of-smoking-on-multiple-primary-cancers-survival-a-retrospective-analysis
#9
A Romaszko-Wojtowicz, A Buciński, A Doboszyńska
According to available literature, active tobacco smoking enhances the risks of recurrence and development of new primary malignancies. Smoking also shortens the survival period for patients with a diagnosed neoplastic disease. Medical records of 1622 patients hospitalized at the Center for Pulmonary Diseases from January 2013 till March 2017 were retrospectively analyzed, out of which 741 cases with a diagnosis of at least one primary cancer were selected, including 111 patients with multiple primary malignancies...
March 17, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29550985/reduced-mitochondrial-dna-content-in-lymphocytes-is-associated-with-insulin-resistance-and-inflammation-in-patients-with-impaired-fasting-glucose
#10
Mohamad Hafizi Abu Bakar, Nany Hairunisa, Hasniza Zaman Huri
Altered mitochondrial DNA (mtDNA) is the most common denominator to numerous metabolic diseases. The present study sought to investigate the correlation between mtDNA content in lymphocytes and associated clinical risk factors for impaired fasting glucose (IFG). We included 23 healthy control and 42 IFG participants in this cross-sectional study. The measurements of mtDNA content in lymphocytes and pro-inflammatory markers derived from both normal and diseased individuals were quantified. Spearman partial correlation and multivariate statistical analyses were employed to evaluate the association between mtDNA content and other metabolic covariates in IFG...
March 17, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29492716/granulomatosis-with-polyangiitis-clinical-course-and-outcome-of-60-patients-from-a-single-center-in-south-india
#11
Vineeta Shobha, Saba Fathima, Ravi Prakash
Granulomatosis with polyangiitis (GPA) previously known as Wegener's granulomatosis is one of the forms of idiopathic systemic vasculitis. There is very scanty data available on GPA in Asian and Indian population. We studied data of 60 patients from southern India, diagnosed with GPA to describe the physical characteristics, the treatment, and outcome. Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study...
February 28, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29492715/mast-cells-and-angiogenesis-in-pancreatic-ductal-adenocarcinoma
#12
REVIEW
Vito Longo, Roberto Tamma, Oronzo Brunetti, Salvatore Pisconti, Antonella Argentiero, Nicola Silvestris, Domenico Ribatti
Mast cells are recognized as critical components of the tumor stromal microenvironment in several solid and hematological malignancies, promoting angiogenesis and tumor growth. A correlation between mast cells infiltration, angiogenesis and tumor progression has been reported for pancreatic ductal adenocarcinoma as well. Mast cells contribute to the aggressiveness of the pancreatic ductal carcinoma enhancing the expression of several pro-angiogenic factors such as vascular endothelial growth factor, fibroblast growth factor-2, platelet-derived growth factor and angiopoietin-1 as well as stimulating the pancreatic cancer cells proliferation by IL-13 and tryptase...
February 28, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29445889/clinical-significance-of-circulating-tumor-cells-from-lung-cancer-patients-using-microfluidic-chip
#13
Chen Qian, Shan Wu, Hongmei Chen, Xiaofen Zhang, Rongrong Jing, Lei Shen, Xudong Wang, Shaoqing Ju, Chunping Jia, Hui Cong
Circulating tumor cells (CTCs) exist in the peripheral blood and have an important role in the disease development, tumor metastasis and clinical surveillance, especially in the process of metastasis. However, the technology of detecting CTCs still had a large challenge since they were rare in the peripheral blood. Here, we developed a size-based microfluidic chip, which contained array and filter channel array that could enrich CTCs from blood samples more quickly and conveniently. Combined with clinical specimen, we analyzed CTCs in 200 lung cancer patients by this microfluidic chip...
May 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29435805/kallikrein-related-peptidase-6-klk6-expression-differentiates-tumor-subtypes-and-predicts-clinical-outcome-in-breast-cancer-patients
#14
Christoforos Haritos, Kleita Michaelidou, Konstantinos Mavridis, Ioannis Missitzis, Alexandros Ardavanis, John Griniatsos, Andreas Scorilas
Novel molecular markers that address the heterogeneity of breast cancer (BC) and provide meaningful prognostic information for BC patients are needed. Kallikrein-related peptidase 6 (KLK6) is aberrantly expressed and functionally implicated in BC and, like other members of the KLK family, may prove a useful molecular tool for clinical management. Our objective was to assess, for the first time, the clinical relevance of KLK6 mRNA expression in BC. Total RNA was isolated from 165 breast tumors, as well as 100 adjacent non-cancerous tumor specimens...
May 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29450785/the-role-of-the-alternative-pathway-of-complement-activation-in-glomerular-diseases
#15
REVIEW
Emilia Łukawska, Magdalena Polcyn-Adamczak, Zofia I Niemir
The complement system (CS) has recently been recognized as a bridge between innate and adaptive immunity that constitutes a very complex mechanism controlling the clearance of pathogens, cellular debris, and immune complexes. Out of three known pathways of complement activation, the alternative pathway (AP) plays a critical role in host defense by amplifying the complement response, independently of initiation pathway and continuously maintaining low-level activity in a process called 'thick-over.' A key molecule of the CS is C3, in which the AP is constantly activated...
February 15, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29417256/plasma-clot-formation-and-clot-lysis-to-compare-effects-of-different-anticoagulation-treatments-on-hemostasis-in-patients-with-atrial-fibrillation
#16
Oliver Königsbrügge, Günter Weigel, Peter Quehenberger, Ingrid Pabinger, Cihan Ay
The effect of direct oral anticoagulants (DOACs) on turbidimetric measurements of plasma clot formation and susceptibility to fibrinolysis may facilitate a comparison between different classes of anticoagulants in plasma samples. We obtained 424 citrate plasma samples from 226 atrial fibrillation patients on anticoagulation and 24 samples without anticoagulation serving as controls. As comparators, we measured the international normalized ratio (INR) for phenprocoumon samples (N = 166), anti-Xa for low molecular weight heparin (LMWH) samples (N = 42), and DOAC levels with mass spectrometry (dabigatran N = 40, rivaroxaban N = 110, apixaban N = 42)...
February 7, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29396624/is-the-1298a-c-polymorphism-in-the-mthfr-gene-a-risk-factor-for-arterial-ischaemic-stroke-in-children-the-results-of-meta-analysis
#17
Beata Sarecka-Hujar, Ilona Kopyta, Michal Skrzypek
An elevated level of homocysteine is a risk factor for vascular diseases, brain atrophy and several other disorders. The 1298A>C polymorphism (rs1801131) leads to mildly decreased MTHFR activity. Previously, it was observed that the MTHFR 1298A>C polymorphism in combined analysis with the MTHFR 677C>T polymorphism increases homocysteine levels. However, conflicting results on its relation to ischaemic stroke in children can be found. We conducted a meta-analysis to analyse possible connections between the MTHFR 1298A>C polymorphism and ischaemic stroke in paediatric patients...
February 2, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28951980/detection-of-promoter-methylation-status-of-suppressor-of-cytokine-signaling-3-socs3-in-tissue-and-plasma-from-chinese-patients-with-different-hepatic-diseases
#18
Ling Wei, Yuan Huang, Rongce Zhao, Jing Zhang, Qiuying Liu, Weibo Liang, Xueqin Ding, Bo Gao, Bo Li, Chengjun Sun, Jingyang He, Xiaoqin Yu, Zhongjian Liu, Aimin Sun, Yang Qin
SOCS3 as an important negative regulator of IL6/JAK/STAT3 signaling pathway may be early critical determinants of carcinogenesis. This study aimed to explore the aberrant promoter methylation of SOCS3 gene in circulating DNA as a noninvasive biomarker for screening hepatocellular carcinoma (HCC) high-risk individuals and for prognosis of HCC patients after partial hepatectomy. We detected its methylation status in 116 liver tissues and 326 plasma specimens of different hepatic diseases and healthy subjects, and its mRNA and protein expression in tissues...
February 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28948382/association-of-serum-bilirubin-with-oxidant-damage-of-human-atherosclerotic-plaques-and-the-severity-of-atherosclerosis
#19
Domenico Lapenna, Giuliano Ciofani, Sante Donato Pierdomenico, Maria Adele Giamberardino, Sante Ucchino, Giovanni Davì
Bilirubin has protective effects against atherosclerotic cardiovascular diseases hypothetically due to its antioxidant-antilipoperoxidative properties. Thus, we investigated whether serum bilirubin is associated with oxidant damage, namely lipid peroxidation, of human atherosclerotic plaques and the severity of atherosclerosis. In this regard, we correlated the levels of serum total bilirubin (STB), direct (conjugated) bilirubin (SDB) and indirect (unconjugated) bilirubin (SIB) with those of fluorescent damage products of lipid peroxidation (FDPL) and lipid hydroperoxides (LOOH) of 32 endarterectomy-derived carotid atherosclerotic plaques...
February 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28884309/globulin-platelet-model-predicts-significant-fibrosis-and-cirrhosis-in-chb-patients-with-high-hbv-dna-and-mildly-elevated-alanine-transaminase-levels
#20
Qiang Li, Chuan Lu, Weixia Li, Yuxian Huang, Liang Chen
The globulin-platelet model (GP) is a new noninvasive liver fibrosis model developed in chronic hepatitis B (CHB) patients. This study aimed to evaluate the diagnostic performance of GP model for liver fibrosis and cirrhosis in CHB patients with high HBV DNA and mildly elevated alanine transaminase (ALT) levels. We enrolled 316 CHB patients with HBV DNA ≥ 4 log 10 copies/mL and 40 IU/L < ALT ≤ 80 IU/L. The GP, aspartate transaminase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4) were calculated...
February 2018: Clinical and Experimental Medicine
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