Balasundaram Nandhini, Yacobu Sureshraj, Mohandass Kaviya, Thangavelu Sangeetha, Kathirvel Bharathi, Balasubramanian Balamuralikrishnan, Pappuswamy Manikantan, Meyyazhagan Arun, Kuchi Bhotla Haripriya, Pushparaj Karthika, Subramaniam Kalidass, Arumugam Vijaya Anand
Thrombocytes (platelets) are the type of blood cells that are involved in hemostasis, thrombosis, etc. For the conversion of megakaryocytes into thrombocytes, the thrombopoietin (TPO) protein is essential which is encoded by the TPO gene. TPO gene is present in the long arm of chromosome number 3 (3q26). This TPO protein interacts with the c-Mpl receptor, which is present on the outer surface of megakaryocytes. As a result, megakaryocyte breaks into the production of functional thrombocytes. Some of the evidence shows that the megakaryocytes, the precursor of thrombocytes, are seen in the lung's interstitium...
2023: Journal of the Renin-angiotensin-aldosterone System: JRAAS