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Tuberculosis

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https://www.readbyqxmd.com/read/28061955/the-role-of-cd30-and-cd153-cd30l-in-the-anti-mycobacterial-immune-response
#1
REVIEW
Nancy D Marín, Luis F García
The establishment of a protective T-cell response against mycobacterial infections involves different co-stimulatory molecules and their respective ligands. Among these molecules the Tumor Necrosis Factor Receptor Super-family (TNFRSF) and the Tumor Necrosis Factor Super-family (TNFSF) are known to be important members. This review analyzes the evidence that CD30 and CD153 (CD30L), members of the TNFRSF and TNSF, play key roles in the T cell-dependent anti-mycobacterial immune response. Mice deficient in either CD30 or CD153, or treated with antibodies blocking the effects or CD30 and CD153, and infected with M...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061954/multiple-cytokine-responses-in-discriminating-between-active-tuberculosis-and-latent-tuberculosis-infection
#2
Jing Wu, Sen Wang, Chanyi Lu, Lingyun Shao, Yan Gao, Zumo Zhou, Heqing Huang, Ying Zhang, Wenhong Zhang
BACKGROUND: Cytokines play an important role in cell-mediated immune responses against Mycobacterium tuberculosis (Mtb) infection. Cytokine profile specifically associated with active tuberculosis (ATB) patients, subjects with latent tuberculosis infection (LTBI) and non-infected individuals remains to be determined. METHODS: We enrolled a total of 92 subjects including patients with ATB (n = 25), LTBI (n = 36) and healthy controls (HC, n = 31) to investigate the cytokine production by peripheral blood mononuclear cells after Mtb purified protein derivative (PPD) stimulation which was evaluated by a beads-based multiplex assay system...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061953/advances-in-basic-and-translational-tuberculosis-research-proceedings-of-the-first-meeting-of-report-international
#3
REVIEW
Carolina Geadas, Sonia K Stoszek, David Sherman, Bruno B Andrade, Sudha Srinivasan, Carol D Hamilton, Jerrold Ellner
RePORT International is a collaborative research network of investigators from multiple countries and institutions with the goal of establishing a bio-repository of specimens and clinical data for the study of active TB and latent TB infection (LTBI). During the first meeting of RePORT International in Boston, Massachusetts, the results of research pertinent to TB control and eradication were presented, including advances in the research of Mycobacterium tuberculosis (MTB) persistence and drug resistance, TB diagnostics, drug and vaccine development...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061952/anti-mycobacterial-function-of-macrophages-is-impaired-in-a-diet-induced-model-of-type-2-diabetes
#4
Md Abdul Alim, Suchandan Sikder, Tahnee L Bridson, Catherine M Rush, Brenda L Govan, Natkunam Ketheesan
Type 2 diabetes (T2D) is one of the major risk factors for tuberculosis (TB). In this study, a diet induced murine model of T2D (DIMT2D) was developed and characterized in the context of metabolic, biochemical and histopathological features following diet intervention. Mycobacterial susceptibility was investigated using Mycobacterium fortuitum as a surrogate. Phagocytic capability of alveolar macrophages and resident peritoneal macrophages were determined by in vitro assays using mycolic acid coated beads and M...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061951/role-and-contribution-of-pulmonary-cd103-dendritic-cells-in-the-adaptive-immune-response-to-mycobacterium-tuberculosis
#5
Vanessa Hui Qi Koh, See Liang Ng, Michelle Lay Teng Ang, Wenwei Lin, Christiane Ruedl, Sylvie Alonso
Despite international control programmes, the global burden of tuberculosis remains enormous. Efforts to discover novel drugs have largely focused on targeting the bacterium directly. Alternatively, manipulating the host immune response may represent a valuable approach to enhance immunological clearance of the bacilli, but necessitates a deeper understanding of the immune mechanisms associated with protection against Mycobacterium tuberculosis infection. Here, we examined the various dendritic cells (DC) subsets present in the lung and draining lymph nodes (LN) from mice intra-tracheally infected with M...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061950/serial-measurements-of-transrenal-mycobacterial-dna-as-indicators-of-the-early-bactericidal-activity-eba-of-antituberculosis-drugs
#6
LETTER
Jan Heyckendorf, Ines Labugger, Lize van der Merwe, Alberto L Garcia-Basteiro, Andreas H Diacon, Christoph Lange
No abstract text is available yet for this article.
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061949/mycobacterium-tuberculosis-rv0560c-is-not-essential-for-growth-in%C3%A2-vitro-or-in-macrophages
#7
Rachel Kokoczka, Dorothée L Schuessler, Julie V Early, Tanya Parish
Mycobacterium tuberculosis Rv0560c, a putative benzoquinone methyl transferase, is heavily induced in response to salicylate exposure. It has some similarity to Escherichia coli UbiG, although its role in ubiquinone or menaquinone synthesis is not clear, since M. tuberculosis is not known to produce ubiquinone. We constructed an unmarked in-frame deletion of Rv0560c in M. tuberculosis to determine its role in vitro. Deletion of Rv0560c in M. tuberculosis had no effect on growth in medium containing salicylate or in its ability to grow in macrophages...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061948/levels-of-microrna-mir-16-and-mir-155-are-altered-in-serum-of-patients-with-tuberculosis-and-associate-with-responses-to-therapy
#8
Vishal Wagh, Anant Urhekar, Deepak Modi
Identification of blood biomarkers that can be useful for predicting Mycobacterium tuberculosis (M.TB) infection, effect of therapy and Multi Drug Resistant (MDR) TB infected individuals is clinically useful for combating tuberculosis epidemic. In this study, we have evaluated the levels of selected miRNAs in serum of TB and MDR TB patients. In addition, we have studied their levels in serum of patients post-therapy. The levels of 4-miRNAs (miR-16, miR-29a, miR-125b and miR-155) were measured in 30 newly diagnosed TB patients, 19 Multi Drug Resistant (MDR) TB patients, 10 patients who completed TB therapy and were TB negative...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061947/b-lymphocytes-forming-follicle-like-structures-in-the-lung-tissue-of-tuberculosis-infected-mice-dynamics-phenotypes-and-functional-activity
#9
Irina Linge, Alexander Dyatlov, Elena Kondratieva, Vadim Avdienko, Alexander Apt, Tatiana Kondratieva
During tuberculosis (TB) infection, B cells form follicles in close vicinity of lung granuloma. We assessed the dynamics of follicle formation, surface phenotypes and functional activity of lung B cells during TB course in genetically susceptible mice. The follicles appeared early post infection and peaked at weeks 7-8. Lung B cells resembled classical B2 cells (CD19(+)IgMloIgD(hi)CD1d(-)CD21/35(int)CD5(-)CD11b(-)CD43(-)), but differed from them by the absence of B2 marker CD23. Lung B-cells constitutively expressed MHC II molecules, presented mycobacterial antigens to immune CD4(+) T-cells and produced high amounts of IL-6 and IL-11, but no classical type 1 (TNF-α, IFN-γ), or anti-inflammatory (IL-10, TGF-β) cytokines...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28061946/gene-xpert-mtb-rif-assay-for-the-diagnosis-of-intra-ocular-tuberculosis-from-vitreous-fluid-samples
#10
LETTER
Kusum Sharma, Vishali Gupta, Aman Sharma, Ramandeep Singh, Megha Sharma, Kanika Aggarwal, Reema Bansal, Paul D Fiorella, Surya Prakash, Amod Gupta
No abstract text is available yet for this article.
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/27865406/an-adverse-immune-endocrine-profile-in-patients-with-tuberculosis-and-type-2-diabetes
#11
R Fernández, A Díaz, L D'Attilio, B Bongiovanni, N Santucci, D Bertola, H Besedovsky, A Del Rey, M L Bay, O Bottasso
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB + T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN-γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865405/identification-of-sp110-in-horse-equus-caballus-isolation-of-novel-splice-variants-and-evidence-of-activation-effects-on-macrophages
#12
Qi Chen, Qi Tong, Hengtao Ge, Wenzhong Li, Jun Liu, Yongsheng Wang, Zekun Guo, Fusheng Quan, Yong Zhang
SP110 has previously shown to be a genetic determinant of host resistance to the intracellular pathogen infection in mouse and human. However, its relevant biological information in large non-primate animals still remains unknown. Here we report the novel discovery and characterization of three transcript variants of horse SP110. The transcript variant 1 (Tv1) of horse SP110 with the longest open reading frame has four domains (Sp100, SAND, PHD and Bromo domain). Tv2 and Tv3 share the same N-terminal sequence as Tv1, which contains Sp100 and SAND...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865404/formulation-studies-of-inha-inhibitors-and-combination-therapy-to-improve-efficacy-against-mycobacterium-tuberculosis
#13
Susan E Knudson, Jason E Cummings, Gopal R Bommineni, Pan Pan, Peter J Tonge, Richard A Slayden
Previously, structure-based drug design was used to develop substituted diphenyl ethers with potency against the Mycobacterium tuberculosis (Mtb) enoyl-ACP reductase (InhA), however, the highly lipophilic centroid compound, SB-PT004, lacked sufficient efficacy in the acute murine Mtb infection model. A next generation series of compounds were designed with improved specificity, potency against InhA, and reduced cytotoxicity in vitro, but these compounds also had limited solubility. Accordingly, solubility and pharmacokinetics studies were performed to develop formulations for this class and other experimental drug candidates with high logP values often encountered in drug discovery...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865403/propidium-monoazide-and-xpert-mtb-rif-to-quantify-mycobacterium-tuberculosis-cells
#14
Xavier A Kayigire, Sven O Friedrich, Miriam N Karinja, Lize van der Merwe, Neil A Martinson, Andreas H Diacon
Propidium monoazide (PMA) penetrates non-viable cells with compromised membranes. PMA has been proposed to improve the specificity of Xpert MTB/RIF (Xpert) for the detection of viable Mycobacterium tuberculosis. This study assessed the effect of PMA on Xpert cycle thresholds (CT) of M. tuberculosis made non-viable under antibiotic pressure. In vitro, we measured the difference between CT with and without PMA (ΔCT) in liquid cultures treated with one of six anti-tuberculosis drugs (isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, moxifloxacin) and found significant ΔCT only with isoniazid and ethambutol for pan-susceptible M...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865402/some-proteins-of-m-%C3%A2-tuberculosis-that-localise-to-the-nucleus-of-thp-1-derived-macrophages
#15
Atul Kumar Agrawal, Rajeev Ranjan, Sharat Chandra, Tofan Kumar Rout, Amit Misra, Thota Jagadeshwar Reddy
Host-pathogen dialectics in tuberculosis (TB) via DNA-protein interactions are emerging. We investigated whether proteins produced by Mycobacterium tuberculosis (Mtb) could translocate to the host nucleus. Using lysates of nuclei purified from Mtb-infected THP-1-derived macrophages, we identified at least 15 proteins of Mtb-origin by electrophoretic and chromatographic separation and mass spectrometry. Western blotting confirmed time-dependent accumulation of Mtb EF-Tu, GroEL, GroES and MtrA in the host nucleus...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865401/relating-annual-migration-from-high-tuberculosis-burden-country-of-origin-to-changes-in-foreign-born-tuberculosis-notification-rates-in-low-medium-incidence-european-countries
#16
Aidan Hanway, Catherine M Comiskey, Katy Tobin, Ronan F O'Toole
The level of immigration from high tuberculosis (TB) burden countries (HBCs) which impacts on the foreign-born TB notification rate is largely unknown. In this work, we performed a cross-sectional analysis of epidemiological data from 2000 to 2013 from nine European countries: Austria, Denmark, Finland, Hungary, Netherlands, Norway, Spain, Sweden, and the United Kingdom. Crude notification rates were calculated for foreign- and native-born populations and a multiple-linear regression model predicting notification rates with HBC population data was generated...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865400/new-mycobacterium-tuberculosis-lam-sublineage-with-geographical-specificity-for-the-old-world-revealed-by-phylogenetical-and-bayesian-analyses
#17
Yann Reynaud, Nalin Rastogi
We recently showed that the Mycobacterium tuberculosis sublineage LAM9 could be subdivided as two distinct subpopulations - each reflecting its unique biogeographical structure and evolutionary history. We subsequently attempted to verify if this genetic structuration could be traced in an enlarged global sample. For this purpose, we analyzed global evolutionary relationships of LAM strains in a large dataset (n = 1923 isolates from 35 countries worldwide) with concomitant spoligotyping and MIRU-VNTR data, followed by a deeper analysis of LAM9 sublineage (n = 851 isolates)...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865399/high-body-mass-index-is-associated-with-heightened-systemic-and-mycobacterial-antigen-specific-pro-inflammatory-cytokines-in-latent-tuberculosis
#18
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Chandrakumar Dolla, Paul Kumaran, Subash Babu
High body mass index (HBMI) has been shown to be protective against active tuberculosis (TB), although the biological mechanism underlying this protection is poorly understood. The immunological association between HBMI and latent TB has never been examined. In order to study the association of HBMI with latent TB, we examined the circulating and TB- antigen or mitogen stimulated levels of a large panel of cytokines in individuals with latent TB (LTB) and high or normal body mass index (HBMI or NBMI). HBMI is characterized by heightened circulating levels of pro-inflammatory (IFNγ, TNFα, IL-22, IL-1α, IL-12 and GM-CSF) cytokines but decreased circulating levels of anti-inflammatory cytokines (IL-4, IL-5 and TGFβ)...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865398/primate-models-of-tuberculosis-faith-based-or-evidence-based-science
#19
EDITORIAL
Robert L Hunter
No abstract text is available yet for this article.
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865397/transmission%C3%A2-of-multi-drug-resistant-tuberculosis-in-mongolia-is-driven-by-beijing-strains-of-mycobacterium-tuberculosis-resistant-to-all-first-line-drugs
#20
Ulziijargal Gurjav, Baasansuren Erkhembayar, Buyankhishig Burneebaatar, Erdenegerel Narmandakh, Oyuntuya Tumenbayar, Grant A Hill-Cawthorne, Ben J Marais, Vitali Sintchenko
BACKGROUND: Mongolia has high and rising rates of multi-drug resistant tuberculosis (MDR-TB). Spatio-temporal and programmatic evidence suggests a major contribution from MDR-TB transmission, but genotypic evidence has not been assessed. METHODS: All MDR-TB cases identified during 2012 were examined. Demographic and bacteriological data were obtained from the National Tuberculosis Reference Laboratory. Isolates of Mycobacterium tuberculosis from culture-confirmed category 1 treatment failures were genotyped using 24-loci mycobacterium interspersed repetitive unit (MIRU-24) analysis...
December 2016: Tuberculosis
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