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Advances in Gerontology, Uspekhi Gerontologii

S A Krivosheev, L A Lobuteva, O V Zakharova, A V Lobuteva
The article examines the indicators of physical and economic accessibility of pharmaceutical care to patients of older age groups with visual impairment from the perspective of the patient-centered approach. The motives of consumers' behavior when choosing pharmacy organizations and ophthalmic preparations are revealed. The estimation of the consumers' satisfaction with the location of pharmacy organizations and the available in them assortment of medicines for treatment and prevention of eye diseases is given...
2018: Advances in Gerontology, Uspekhi Gerontologii
B Zh Turebekov, L T Nurkatova
In this article, the authors analyze the new institution of social security: integrated social services for families with older people. A study is conducted on the example of the Republic of Kazakhstan as a country at the threshold of the critical level of population aging. The authors analyze statistics, normative acts, conduct a survey of recipients of social services and justify the introduction of the integrated services system as a progressive social security tool. It is proposed to put the client-oriented approach in the basis of the system (orientation to the requirements of consumers of social services)...
2018: Advances in Gerontology, Uspekhi Gerontologii
R Dahms, M Haesner
Recent research on music and music-based interventions for people with dementia (PwD) is focused on changes of psychological and cognitive functions. Little is known about the role of biography in the importance of music to PwD. A qualitative study was conducted to identify the phases of their life in which PwD were influenced by music. 20 semi-structured interviews with PwD from nursing homes and PwD cared for at home were conducted. Additionally, their relatives were interviewed separately. The results were analysed relating to four categories divided into past and present with the aim of identifying the changes in daily routine and challenges for everyday care...
2018: Advances in Gerontology, Uspekhi Gerontologii
L N Chikinova, N S Zapary, Z V Boltenko, S B Shakhsuvaryan
The analysis of dynamics of formation of primary, repeated and general disability owing to malignant new growths at elderly people of the city of Moscow during 2005-2014 is presented in article, the main medico-social characteristics of this contingent in comparison with indicators are determined by Central Federal District and the Russian Federation.
2018: Advances in Gerontology, Uspekhi Gerontologii
G G Aminova
In recent years in many countries with increasing duration of human life, there is an aging population. In this regard, studies of lymphoid tissue that provides immune processes in the human body, are of particular relevance. It was studied lymphoid tissue of the Appendix person aged 54-81 and 26-35 years with histological and statistical methods. In the older age groups there was a reduction and restructuring of lymphoid tissue with partial modified lymphoid nodules. Most nodules have no light centers to continue the process of blast transformation...
2018: Advances in Gerontology, Uspekhi Gerontologii
L M Tibekina, D O Boricheva, A A Nikolaeva
Current research aimed to reveal clinical and neurological features of ischaemic stroke (IS) in patients suffering from cerebral venous insufficiency (CVI) combined with arterial hypertension (AH) and to identify its risk factors. Examination data of 112 patients with IS (aged 60-93 years old; mean age 72,1±2,6 years old, males - 39 (34,8%), females - 73 (65,2%), admitted at regional vascular center of St. Elizabeth City Hospital in Saint Petersburg, highlighted that cephalgic syndrome and vestibulocerebellar dysfunction occurred more frequently in stroke patients with CVI...
2018: Advances in Gerontology, Uspekhi Gerontologii
A P Spitsin, T A Pershina, Y K Tsarev
Central hemodynamics and vegetative regulation of heart rhythms in males depending on age were studied. To evaluate and estimate vegetative regulation a method of variative pulsometry was used. It was used on the basis of analysis of variable heart rhythm (temporary and spectral). Certain tendencies of changes of central hemodynamics and indicators of variable heart rhythm in different age periods were revealed. SDNN, RMSSD and power in HF-range decreased. Baevsky's index of tension and VLF-output increased...
2018: Advances in Gerontology, Uspekhi Gerontologii
V S Myakotnykh, E S Ostapchuk, V L Postovalova
There was held stationary survey of 661 patients in different age: 234 - from 60 to 102 years, 427 - from 18 to 59 years. Identify options for pathology, clearly increasing its prevalence in parallel with the increase of age. It is, first and foremost, diseases of musculoskeletal apparatus, gastrointestinal tract and cardiovascular system. At the same time, acute violations of cerebral circulation in the form of strokes, on the contrary, prevailed among persons under the age of 60 years, and an increase in the frequency of ischemic heart disease, angina without myocardial infarction among patients of elderly and senile age in relation to persons under the age of 60 years was insignificant...
2018: Advances in Gerontology, Uspekhi Gerontologii
E O Utenkova, O N Lyubeznova, E V Noskova, V V Noskova
The article compares the flow of intestinal infections in elderly and young people. Analyzed the medical records of 172 persons 60-85 years and 82 history persons 20-40 years with salmonellosis, shigellosis and rotavirus gastroenteritis. It is revealed that bacterial intestinal infections, salmonellosis and shigellosis, those over 60 years of age have the clinical differences and flow is heavier than in patients 20-40 years. Clinic of rotaviral gastroenteritis is not age-appropriate. Knowledge of clinic of intestinal infections in persons of elderly and senile age should your doctor for early diagnosis and proper treatment of patients of this category...
2018: Advances in Gerontology, Uspekhi Gerontologii
G A Livanov, A N Lodyagin, A L Kovalenko, B V Batotsyrenov, S I Glushkov, G A Prokopovich, A M Antonova, G V Shestova, A A Ippolitova
In this article materials obtained during treatment of 61 patients with acute poisoning with phenobarbital, which is part of Corvalol and Valocordin, are presented. It has already been established that phenobarbital acute poisoning in elderly and senile patients is accompanied by more frequent development of central nervous system, respiratory system (pneumonia) and cardiovascular system complications, which cause more severe clinical course and risk of an adverse outcome of acute poisoning. This research has shown that for hypoxia correction during phenobarbital acute poisoning in elderly and senile patients it is advisable to include Reamberin in the treatment regimen, which has no adverse effects on central haemodynamic parameters and effectively reduces severity of metabolic disorders...
2018: Advances in Gerontology, Uspekhi Gerontologii
F A Bichkaeva, N I Volkova, A A Bichkaev, T V Tretykova, O S Vlasova, E V Nesterova, B A Shengof, N F Baranova
The study involved 106 elderly people of the Arctic aged 61-74 years, 42 of them were residents of the Subarctic region (SR) and 64 residents of the Arctic region (AR). Using gas-liquid chromatography there was determined the serum content of saturated fatty acids (SFA): short-chain (SCFA), medium-chain (MCFA) and long-chain (LCFA); and the levels of carbohydrate metabolism parameters were determined by spectrophotometric methods. Correlation analysis showed that elderly people of SR had no significant interrelationships between the contents of SCFA, MCFA and LCFA, since all the correlation dependences were weak (r=0,2-0,29, p=0,08-0,786), against AR with a lower occurrence of high values of glucose (Glu), lactate (Lac) and low pyruvate (Pyr)...
2018: Advances in Gerontology, Uspekhi Gerontologii
L B Kim, G S Russkih, A N Putyatina, O B Tsypysheva
Here we present the study of enzymes involved in the regulation of extracellular matrix metabolism. It was the first study of this kind in the European part of the Arctic zone of the Russian Federation (AZRF). The contents of matrix metalloproteinases (MMP-1, -2, -3, -9) and tissue inhibitors of matrix metalloproteinases (TIMP-1, -2, -4) were measured in blood plasma of 91 men in AZRF (67o N) and 14 men in Western Siberia. The contents of MMP-1, MMP-9, TIMP-1 and TIMP-4 in plasma of northerners were higher compared to those of the residents of Western Siberia (55o N)...
2018: Advances in Gerontology, Uspekhi Gerontologii
E A Hizhkin, V A Ilyukha, I A Vinogradova, E P Antonova, A V Morozov
We studied the age-related features of circadian rhythms of superoxide dismutase (SOD) and catalase activity in the liver of rats under light deprivation. In standard light conditions (LD), significant daily fluctuations in SOD activity with a maximum at 07:00 am was detected only in young animals (1,5 months) but catalase activity was observed in young (1,5 months) and in adults (7,5 months) with peak at 04:00 am. The daily dynamics of total and specific activity of SOD and catalase in the liver in young and adult rats differed depending on the period of ontogeny in which the impact of light deprivation began...
2018: Advances in Gerontology, Uspekhi Gerontologii
Y I Pigolkin, G V Zolotenkova, A P Sereda, D D Zolotenkov, N V Gridina
The study presents the results of a complex histomorphometric research of the features of the age-related dynamics of bone tissue. As a study material we used samples of the distal epiphysis and diaphysis of the left tibia from 348 corpses of males with a known age from 0 to 90 years. A group of microosteometric features, that have the strongest correlation with age, is established in different age groups; their quantitative characteristics are given. It is clarified that the trends of age-related changes in the structural components of bone tissue correspond to the basic patterns of growth, remodeling, depend on the species and their localization...
2018: Advances in Gerontology, Uspekhi Gerontologii
A V Chaplygina, N L Vekshin
A comparison of the lipofuscin (aging pigment) content in four organs (liver, kidney, heart, brain) of young and adult rats, as well as in a suspension of hepatic mitochondria, was made. It was demonstrated that mitochondrial lipofuscin - mitolipofuscin, fluorescing in the blue region, makes the main contribution to hepatic lipofuscin. It is assumed that mitolipofuscin in other organs also makes a significant contribution. It is shown that accumulation of lipofuscin with age occurs in all organs of rats, but least of all in the brain...
2018: Advances in Gerontology, Uspekhi Gerontologii
E V Bolotova, V V Yavlyanskaya, A V Dudnikova
The aim of the study was to examine the relationship of vitamin D levels with markers of cardiorenal syndrome in patients with COPD depending on the severity of bronchial obstruction.198 patients with COPD were divided into 2 groups depending on the severity of bronchial obstruction. A deficiency of vitamin D was significantly more prevalent in COPD patients with GFRcys <60 ml/min/1,73 m2 compared to patients with preserved renal function. A medium positive correlation of vitamin D levels with the severity of bronchial obstruction (r=0,419, p=0,001), medium negative correlation of vitamin D levels with exacerbation frequency (r=0,421, p=0,01) and CRP (r=0,301, p=0,02) were observed...
2018: Advances in Gerontology, Uspekhi Gerontologii
J A Safonova, E G Zotkin, G M Glazunova, E L Strukov
The purpose of the study was to analyze the frequency of detection of vitamin D deficiency in elderly people, identify clinically significant diseases, accompanied by a deficiency of vitamin 25(OH)D. A retrospective cohort study was conducted in 506 patients over 65 years of age (74,1±6,5 years). Patients were divided into three age groups: group A 65-74 years, group B 75-84 years, group C 85 years and older. The study of blood samples was carried out from September to May. The level of vitamin 25(OH)D was determined by the method of chemiluminescent immunoassay on the Abbott Architect 8000 analyzer (USA)...
2018: Advances in Gerontology, Uspekhi Gerontologii
D V Varganova, I A Vinogradova, E A Lugovaya
The purpose of this research was to estimate the element status of elder Petrozavodsk citizens and to compare them with the same characteristic of people living in the central part of Russia. The hair samples taken from people aged 60 and more were examined to study the content of 25 macro- and micro elements using the method of atom-emission and mass spectrometry with inductively bonded argon plasma. No misbalance was found in Al, As, Be, Ni and minor misbalance was found in Cd, Li, Sn, V. Toxic elements Hg and Pb and essential element B were found in hair samples in higher concentrations as compared to the referent values...
2018: Advances in Gerontology, Uspekhi Gerontologii
D V Plaksina, I V Ekimova
It is generally accepted that advanced age is the main risk factor for the development and progression of Parkinson's disease (PD). However, data that experimentally confirm the dependence on the age of the rate of neurodegeneration progression and the activity of compensatory processes in the nigrostriatal system in the development of PD are absent in the modern literature. The present study uses a model of neurodegeneration of the nigrostriatal system in rats of different age groups, created by the microinjections of the proteasome inhibitor lactacystin (LC) into the substantia nigra pars compacta (SNpc)...
2018: Advances in Gerontology, Uspekhi Gerontologii
G L Safarova, N M Kalmykova, A A Safarova
Dynamics of life expectancy at birth (LE0) and at older ages has been analyzed and the contribution of older ages (60+) to the life expectancy changes has been estimated for greatest Russian megacities Moscow and Saint-Petersburg. The contributions of aggregated age groups to differences of LE0 values for Moscow and Saint-Petersburg have been studied. It has been found, in particular, that the increase in life expectancy at older ages makes a significant contribution to the LE0 growth.
2018: Advances in Gerontology, Uspekhi Gerontologii
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