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Advances in Gerontology, Uspekhi Gerontologii

I A Balandina, L M Zheleznov, A A Balandin, P V Kosareva, D V Borodulin, D G Amarantov
The science work is based on morphological research of cerebellums of 219 corpses of people (108 man and 111 woman) of young and old age. There were used such research methods as organometric, histological and morphometric. During study a comparative analysis of the mass, linear dimensions, thickness of cerebellar cortex of young and old age was conducted. The regularities of age variability of organometric characteristic of cerebellum were revealed and they are found in the reduction of mass and linear dimensions of the people of senile age in comparison with younger people...
2016: Advances in Gerontology, Uspekhi Gerontologii
I A Balandina, L M Zheleznov, A A Balandin, P V Kosareva, D V Borodulin, D G Amarantov
In this science work there were conducted such researches as organometric, histological, immunomorphologic and morphometric of cerebellar cortex of 219 corpses of people (108 man and 111 woman) of young and old age. A comparative analysis of the parameters of bulb-shaped neurons in these ages revealed decrease of their height and width. It is found that distance between interval nerve cell bodies of ganglionic layer increases with age that obviously associated with progressing disorganization and death of bulb-shaped neurons...
2016: Advances in Gerontology, Uspekhi Gerontologii
M Yu Boboshko, L E Golovanova, E V Zhilinskaia, E A Ogorodnikova
The results of studying the features of auditory perception of speech stimuli in aged patients with hearing loss are presented in the article. 145 patients with moderate to severe sensorineural hearing loss from 52 to 90 years old underwent the tonal threshold audiometry and the tests battery to evaluate central auditory pathways functioning: the gap detection test, frequency difference limens, masking level difference, dichotic digits test. After analyzing speech discrimination scores of monosyllable words in quiet and in noise significantly worse results of all listeners in comparison with listeners with normal hearing are revealed; the deterioration of speech discrimination scores depending on age is noted...
2016: Advances in Gerontology, Uspekhi Gerontologii
V D Kosachev, T M Alekseeva, A N Khalmurzina
In the present work the results of the clinic-epidemiological analysis of 223 patients with the onset of the myasthenia at 60 y. o. and later, admitted and treated in the clinic of neurology for the passed 25years are represented. A dynamic growth of incidence of the late-onset myasthenia through the passed 10 years was administered. We administered a prevalence of the generalized form of the myasthenia gravis (61,5 %). The whole clinical table of the myasthenia was developed during an year in 76,7 % of the cases...
2016: Advances in Gerontology, Uspekhi Gerontologii
A A Kulesh, V E Drobakha, V V Shestakov
In the acute phase of ischemic stroke 73 patients aged from 61 to 86 years and 47 patients aged 36 to 60 years underwent a comprehensive neuropsychological testing, evaluation of the concentration of 6-sulfatoximelatonin 6-sulfatoximelatonin in the night urine and brain MRI morphometry in some patients. The control group consisted of 14 persons without cerebrovascular disease. Younger and middle-aged patients had higher levels of 6-sulfatoximelatonin compared to both controls and elderly patients. The level of the metabolite in patients older than 60 years and the control group did not differ...
2016: Advances in Gerontology, Uspekhi Gerontologii
K L Kozlov, I I Bolotov, N S Linkova, A O Drobintseva, V Kh Khavinson, M M Dyakonov, L S Kozina
Peptide KED (Lys-Glu-Asp) has vasoprotective effects and is effective substance in treatment of of atherosclerosis and other cardio-vascular disorders in elderly people. One of the probable mechanisms of biological activity of this peptide is epigenetic genes regulation. These genes can coding proteins, which are markers of endothelium functional activity. The goal of investigation was to study the KED peptide effect on signal molecules expression in normal, atherosclerotic and restenotic endothelium in vitro...
2016: Advances in Gerontology, Uspekhi Gerontologii
R A Gajfulin, A N Sumin, O G Arhipov
The aim of study was to examine echocardiographic indices of right heart chambers in patients with coronary artery disease in different age groups. On 678 patients aged 38-85 years, who underwent echocardiography, are including with the use of spectral tissue Doppler. Obtained 2 age groups: 1st - patients up to 60 years (n=282) and group 2nd - patients 60 years and older (n=396). In the analysis the obtained results in patients with coronary heart disease in older age groups showed an increase in right ventricular wall thickness, systolic and average pressure in the pulmonary artery...
2016: Advances in Gerontology, Uspekhi Gerontologii
I N Medvedev
The article contains the results of a study platelet aggregation in carefully selected clinically healthy elderly. The study was performed on 121 clinically healthy elderly people, leading a healthy lifestyle, and do not have metabolic, cancer and cardiovascular disease. We surveyed people between 61 and 74 years showed a significant weakening of antioxidant protection and increasing in platelet levels in their lipid peroxidation. Platelet aggregation in vitro with a variety of inducers in the elderly showed age-dependent gain...
2016: Advances in Gerontology, Uspekhi Gerontologii
E V Bolotova, A V Dudnikova
The aim was to study the prevalence of risk factors for chronic kidney disease (CKD) and frequency of CKD in patients with chronic obstructive pulmonary disease (COPD). 300 patients with a diagnosis of COPD I-IV were examined. A high prevalence of risk factors CKD was revealed, there are close correlations between the risk factors and the age of patients and severity of obstructive disorders and the spectrum of comorbid pathology. The diagnosis of CKD 1-3B stage is set for 47,6 % of the patients. The obtained data determine the necessity of close attention by clinicians to the study of renal function in elderly patients with COPD...
2016: Advances in Gerontology, Uspekhi Gerontologii
V V Petrov
Vascular system of the nasal cavity has a complex structural organization and a wide range of functionality. However, with age, the hemodynamics of the nasal cavity undergoes specific changes, detection of which is of practical importance for gerontology and medicine. This paper presents the results of the study of hemodynamics of the nasal cavity in Mature, elderly and senile age by the method of rheorinography . Identified critical periods of functional changes of blood flow of the nasal cavity: the elderly (exit definitivno state) and old age (involution hemodynamic function and the reduction of its compensatory capacity)...
2016: Advances in Gerontology, Uspekhi Gerontologii
K A Kireev, A A Fokin, A V Krasnopeev, T S Kireeva
There were 85 cases of endovascular treatment of acute myocardial infarct (AMI) in patients older than 75 years old in our investigation. The age of patients was from 75 to 96 years, the average age - 82,6±1,3 years. As for gender, all patients were divided into 2 groups: men - 37 (43,5 %) and female - 48 (56,5 %). The study was conducted in the following areas: determination of the baseline status of patients, analysis of technical aspects of diagnostic and medical percutaneous coronary interventions (PCI), as well as the comparison of results...
2016: Advances in Gerontology, Uspekhi Gerontologii
A S Petrov, K L Kozlov, V N Fedorets, D A Korotkov
In the review published data on what modern antithrombotic drugs are used to support percutaneous coronary intervention in the treatment of acute coronary syndrome with ST segment elevation on the electrocardiogram in patients of older age groups. It was shown the effectiveness and safety of new pharmacological combinations using both anticoagulants and antiplatelet agents as in patients with acute coronary syndrome in elderly. It was highlighted also the need to find new combinations of anticoagulants and antiplatelet agents, to improve the prognosis in elderly persons subjected to percutaneous coronary intervention in patients with ACS...
2016: Advances in Gerontology, Uspekhi Gerontologii
I A Zolotovskaia, I L Davydkin
To date, according to numerous national and international research, vascular stiffness has programmed the aging process significantly influences the risk of developing cardiovascular disease and total cardiovascular mortality in the elderly. Attention should be paid to patients with cardiac arrhythmias, especially atrial fibrillation (AF), as they are in a high risk of developing primary and recurrent thromboembolic events. Taking into account the age factor and comorbidity disease among these patients is extremely high risk of death and disability...
2016: Advances in Gerontology, Uspekhi Gerontologii
V S Myakotnykh, M N Torgashov, K V Egorin, V N Meshchaninov, V I Gavrilov, T A Borovkova, E M Zvezdina, T Y Verzhbitskaya, E L Tkachenko
In the monitoring process 110 representatives of different age groups held a comparative analysis of the efficacy and safety of several geroprotective techniques, including the use of dry carbon dioxide baths, hyperbaric oxygen therapy, therapeutic massage and receiving Oligopeptide preparations containing complexes lysyl-glutamyl-asparagin and glutamyl-asparagin-arginine (Vezugen and Pinealon). The most pronounced positive impact on indicators of biological age were detected during the combined use of these two Oligopeptide complexes...
2016: Advances in Gerontology, Uspekhi Gerontologii
N A Kutukova, P G Nazarov, G V Kudryavtseva, V I Shishkin
Mast cells (MC) are present in the skin and mucous membranes, lymphoid organs, intestine wall and brain, where they are located close to the blood and lymphatic vessels and nerve terminals. As a source of a large number of biologically active substances, many of which are released quickly into the environment as a result of degranulation process, mast cells play an essential role in the regulation of physiological processes in the tissues where they are present. Changing the MC population and activity in the tissues during aging is associated with age-related changes of the skin and mucous membranes, the development of central nervous system disorders such as itching, headache, joint and muscle pain, memory loss, attention deficits, depression, anxiety and depressive disorders, autism, Alzheimer's disease and multiple sclerosis...
2016: Advances in Gerontology, Uspekhi Gerontologii
N N Golubtsova, F N Filippov, A G Gunin
At present time, relationships between lamins and processes leading to aging are established. Mutations of genes of lamins lead to diseases, one of them is progeria. This disease is caused by violation of splaysing of lamin A gene and accumulation the farnezylated prelamin A (progerin) in the nucleus. LAP-2 is an important factor which regulates and stabilizes the lamin A. However, roles of lamin A and LAP-2 in behavior of population of dermal fibroblasts in relation to age were not examined. The aim of this research was to study A type lamin and LAP-2 in human skin at different ages...
2016: Advances in Gerontology, Uspekhi Gerontologii
A V Makrushin, N V Aladin
Endogenous decline in homeostatic characteristics of supraorganismal level systems is similar to individual senescence. Similarity is in the fact that this decline as individual senescence is called by negative consequences from specialization of elements the system consists. In systems of supraorganismal level these effects are analogues of parametabolic reactions of senescence individuals.
2016: Advances in Gerontology, Uspekhi Gerontologii
I B Sokolova, I V Sergeev, O R Fedotova, N N Melnikova, D P Dvoretsky
We studied the density of the microvascular network in the pia mater, the tissue perfusion and saturation of the oxygen of sensorimotor cortex of hypertensive rats of different ages. Our investigations shown that the microvascular density in the pia mater was not only decreased, but also was increased. The perfusion of sensorimotor cortex was reduced and tissue saturation was enlarged. By the age of 12 months orienting-exploratory rats behavior became worse significantly in all major indicators of the test «open field»...
2016: Advances in Gerontology, Uspekhi Gerontologii
A I Bozhkov, Yu V Nikitchenko, E M Klimova, O S Linkevych, K M Lebid, A M M Al-Bahadli, M M A Alsardia
The role of the prooxidant-antioxidant and immune systems in formation of age-related adaptive responses to chronic effects of toxic substances (copper ions) was studied. In this purpose in young and old animals by multiple sequential administration of copper sulfate was induced liver fibrosis. Using this model the characteristics of prooxidant-antioxidant and immune systems, and physiological characteristics of were assessed. The Cu-induced liver fibrosis was accompanied by the oxidative stress and a significant reduction in cell immune activity...
2016: Advances in Gerontology, Uspekhi Gerontologii
I V Maiborodin, M K Agzaev, T M Ragimova, V I Maiboriduna
The features of submandibular lymph node (LN) reactions after lower jaw tissue damage at old rats were studied by method of light microscopy. In LN of old rats for all terms of observation, including intact control, the volume of connective tissue is considerable increased. Besides, old animals in LN have of more change duration of a cortical plateau volume, less - of paracortex and lymphoid nodules without light centers. Features of cellular element number consisted in considerable decrease in quantity of lymphocytes, mitotic figures, immunoblasts and plasmablasts against increase in keeping of macrophages, cells with destruction, stromal elements and erythrocytes...
2016: Advances in Gerontology, Uspekhi Gerontologii
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