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Swiss Medical Weekly

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https://www.readbyqxmd.com/read/27922174/authors-reply-to-the-technical-comment-from-joelle-michaud-and-goranka-tanackovic
#1
Marc Blondon, Pierre Fontana
No abstract text is available yet for this article.
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27922173/about-pill-protect%C3%A2
#2
Joelle Michaud, Goranka Tanackovic
No abstract text is available yet for this article.
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27922171/connexins-and-pannexins-from-biology-towards-clinical-targets
#3
Paolo Meda, Jacques-Antoine Haefliger
Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the extracellular medium, via membrane channels made of connexin and pannexin proteins. These channels are a necessary component of all human tissues. Here, we review the biological essentials of the connexin and pannexin families, and the roles of these proteins in the function of cells which are central to major human diseases...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27922168/update-of-the-swiss-guidelines-on-post-treatment-lyme-disease-syndrome
#4
Johannes Nemeth, Enos Bernasconi, Ulrich Heininger, Mohamed Abbas, David Nadal, Carol Strahm, Stefan Erb, Stefan Zimmerli, Hansjakob Furrer, Julie Delaloye, Thierry Kuntzer, Ekkehard Altpeter, Mathias Sturzenegger, Rainer Weber, For The Swiss Society For Infectious Diseases And The Swiss Society For Neurology
Lyme borreliosis is caused by Borrelia burgdorferi sensu lato infection, which responds well to antibiotic therapy in the overwhelming majority of cases. However, despite adequate antibiotic treatment some patients report persisting symptoms which are commonly summarised as post-treatment Lyme disease syndrome (PTLDS). In 2005, the Swiss Society of Infectious Diseases published a case definition for PTLDS. We aimed to review the scientific literature with a special emphasis on the last 10 years, questioning whether the definitions from 2005 are still valid in the light of current knowledge...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27922167/cost-effectiveness-of-primarily-surgical-versus-primarily-conservative-treatment-of-acute-and-subacute-radiculopathies-due-to-intervertebral-disc-herniation-from-the-swiss-perspective
#5
Zanfina Ademi, Viktoria Gloy, Dominik Glinz, Heike Raatz, Joris Van Stiphout, Heiner C Bucher, Matthias Schwenkglenks
AIMS OF THE STUDY: To assess the cost-effectiveness of primarily surgical treatment (PST) versus primarily conservative treatment (PCT) in adults with intermediate severity, acute or subacute, lumbar radicular syndrome due to intervertebral disc herniation. METHODS: A decision analytic model from healthcare system and societal perspectives was used to compare outcomes and costs of PST with those of PCT (physiotherapy, epidural injection and medication). Treatment pathways and quality of life were obtained from published clinical trials...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27922165/excess-mortality-during-the-warm-summer-of-2015-in-switzerland
#6
Ana M Vicedo-Cabrera, Martina S Ragettli, Christian Schindler, Martin Röösli
QUESTION UNDER STUDY: In Switzerland, summer 2015 was the second warmest summer for 150 years (after summer 2003). For summer 2003, a 6.9% excess mortality was estimated for Switzerland, which corresponded to 975 extra deaths. The impact of the heat in summer 2015 in Switzerland has not so far been evaluated. METHODS: Daily age group-, gender- and region-specific all-cause excess mortality during summer (June-August) 2015 was estimated, based on predictions derived from quasi-Poisson regression models fitted to the daily mortality data for the 10 previous years...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27922162/nonmelanoma-skin-cancer-in-mountain-guides-high-prevalence-and-lack-of-awareness-warrant-development-of-evidence-based-prevention-tools
#7
Alexander Zink, Elisabeth Koch, Florian Seifert, Markus Rotter, Christoph D Spinner, Tilo Biedermann
AIMS OF THE STUDY: Nonmelanoma skin cancer (NMSC) is the most common cancer in Switzerland and Europe. The main causative factor is exposure to ultraviolet radiation, which puts outdoor workers in general at a higher risk of developing NMSC than indoor workers. However, few studies have clinically examined the risk of developing NMSC to outdoor workers, especially mountain guides. We aimed to investigate the prevalence of NMSC and corresponding precancerous lesions, and the associated risk behaviour of mountain and ski guides in order to develop future prevention programmes...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878799/microsurgery-robots-addressing-the-needs-of-high-precision-surgical-interventions
#8
Leonardo S Mattos, Darwin G Caldwell, Giorgio Peretti, Francesco Mora, Luca Guastini, Roberto Cingolani
Robotics has a significant potential to enhance the overall capacity and efficiency of healthcare systems. Robots can help surgeons perform better quality operations, leading to reductions in the hospitalisation time of patients and in the impact of surgery on their postoperative quality of life. In particular, robotics can have a significant impact on microsurgery, which presents stringent requirements for superhuman precision and control of the surgical tools. Microsurgery is, in fact, expected to gain importance in a growing range of surgical specialties as novel technologies progressively enable the detection, diagnosis and treatment of diseases at earlier stages...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878798/how-can-patients-and-their-physicians-contribute-to-an-outbreak-investigation-experiences-from-a-nationwide-listeriosis-outbreak-in-switzerland
#9
Sabine Kiefer, Kerstin Kling, Roger Stephan, Martin W Bratschi, Marianne Jost, Philipp Justus Bless, Claudia Schmutz, Daniel Mäusezahl, Kaspar Wyss, Mirjam Mäusezahl-Feuz, Christoph Hatz
QUESTIONS UNDER STUDY/PRINCIPLES: Gathering patient information to contain an outbreak of Listeria monocytogenes is difficult because of the patients' severe illness or death. Extending the range of interviewees to acquire epidemiological data can thus be important to maximise information. METHODS: We built the current analysis on a case-case outbreak investigation conducted during a Swiss listeriosis outbreak between 30 January and 11 May 2014, including 31 patients with confirmed L...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878797/choosing-wisely-at-the-end-of-life-the-crucial-role-of-medical-indication
#10
Gian Domenico Borasio, Ralf J Jox
At the end of life, several treatments are administered routinely that lack medical indication and may cause significant harm to patients. Examples include artificial hydration and oxygen therapy in the dying phase, as well as enteral nutrition in advanced dementia. Medical indication is defined as the appropriateness of a therapeutic or diagnostic measure in the patient's concrete clinical situation, in light of the best available evidence. The decision about the absence or presence of a medical indication is a core competence of physicians...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878796/patent-foramen-ovale-a-novel-cardiovascular-risk-factor-in-patients-with-sleep-disordered-breathing-and-high-altitude-dwellers
#11
Emrush Rexhai, Urs Scherrer, Stefano F Rimoldi
Diseases associated with chronic hypoxaemia are a leading cause of morbidity and mortality in Western countries. Epidemiological data indicate that cardiovascular diseases contribute substantially to this problem, but the underlying mechanisms are incompletely understood. Sleep disordered breathing and high altitude exposure are frequent conditions associated with hypoxaemia. Recent evidence suggests that in these conditions the concomitant presence of a patent foramen ovale plays an important pathogenic role...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878795/transcutaneous-versus-blood-carbon-dioxide-monitoring-during-acute-noninvasive-ventilation-in-the-emergency-department-a-retrospective-analysis
#12
Christian Michael Horvath, Martin Hugo Brutsche, Florent Baty, Jochen Julius Rüdiger
QUESTIONS UNDER STUDY: Transcutaneous measurement of carbon dioxide (PtCO2) has been suggested as an alternative to invasively obtained PaCO2 for the monitoring of patients with hypercapnic respiratory failure during noninvasive ventilation (NIV). Current data on monitoring in hypoxaemic respiratory failure are scarce and show conflicting results in hypercapnic patients in the emergency department. METHODS AND SETTING: We performed a retrospective comparison of real-time PtCO2 (SenTec Digital Monitor) and arterial/venous carbon dioxide tension (PaCO2/PvCO2) measurements in patients with severe hypoxaemic and/or hypercapnic respiratory failure during NIV...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878794/varicosities-of-the-lower-extremity-new-approaches-cosmetic-or-therapeutic-needs
#13
Luca Spinedi, Heiko Uthoff, Sasan Partovi, Daniel Staub
Varicose veins of the lower extremity (VVLE) are a frequently encountered vascular disorder in the general population. The general view that VVLE are a non-serious disease with primarily aesthetic impact is a common misconception, as the disease can have a significant negative impact on generic and disease-specific quality of life. Further, VVLE may be associated with potentially threatening clinical conditions, such as chronic venous ulceration, venous thromboembolism and haemorrhage from ruptured varicose veins...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878793/novel-cases-of-amyotrophic-lateral-sclerosis-after-treatment-of-cerebral-arteriovenous-malformationss
#14
Michael Linnebank, Cameron G McDougall, Stefanie Krueger, Saskia Biskup, Manuela Neumann, Michael Weller, Antonios Valavanis, Johannes Prudlo
Previous case studies reported nine patients with cerebral arteriovenous malformations (AVM) who developed amyotrophic lateral sclerosis (ALS) after AVM embolisation. Here, we describe three novel cases of ALS which developed 13-34 years after treatment, including embolisation, of cerebral AVM. This study provides further arguments supporting the thesis that embolisation of cerebral AVM might influence the risk of later ALS development.
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878792/astrocyte-power-fuels-neurons-during-stroke
#15
Stefano Pluchino, Luca Peruzzotti-Jametti, Christian Frezza
No abstract text is available yet for this article.
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878791/new-concepts-in-the-management-of-dyslipidaemiaa
#16
Baris Gencer, Nicolas Rodondi, Francois Mach
Recently, the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) published a consensus paper giving guidance on the definition and management of statin-associated muscle symptoms (SAMS), as well as the use of proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in very high-risk patients. The occurrence of SAMS can have a major negative impact on treatment adherence and, consequently, on the prognosis of cardiovascular diseases. In addition, both the ESC guidelines on the prevention of cardiovascular disease (CVD) in clinical practice with sections addressing global strategies to minimise the burden of CVD at population and individual levels, and the 2016 ESC/EAS guideline for the management of dyslipidaemias, focus on evaluation and treatment of SAMS...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878790/additional-malignancies-in-patients-with-neuroendocrine-tumours-analysis-of-the-swissnet-registry
#17
Attila Kollár, Annika Blank, Aurel Perren, Lukas Bütikofer, Christoph Stettler, Emanuel Christ
PRINCIPLES: Neuroendocrine neoplasms (NENs) are believed to be associated with an increased risk for additional malignancies (AMs). We aimed to (1) assess the occurrence of AM in NEN patients (2) investigate the characteristics and temporal relationship of NEN patients with and without AM. METHODS: The SwissNET registry has prospectively documented patients with NEN since 2008, covering the entire area of Switzerland. Clinical characteristics, functionality, location and histology of NEN as well as survival of all consecutive patients were retrieved...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878789/regional-sociocultural-differences-as-important-correlate-of-physical-activity-and-sedentary-behaviour-in-swiss-preschool-children
#18
Claudia S Leeger-Aschmann, Einat A Schmutz, Thomas Radtke, Tanja H Kakebeeke, Annina E Zysset, Nadine Messerli-Bürgy, Kerstin Stülb, Amar Arhab, Andrea H Meyer, Simone Munsch, Oskar G Jenni, Jardena J Puder, Susi Kriemler
QUESTION: Regional differences in physical activity in school-aged children and adults even within one country with the same political and health care system have been observed and could not be explained by sociodemographic or individual variables. We analysed whether such differences were already present in preschool children. METHODS: Swiss children from 84 childcare centres in five cantons (Aargau, Bern, Fribourg, Vaud, Zurich) comprising about 50% of the population of the country participated...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878788/sun-protective-behaviour-and-sunburn-prevalence-in-primary-and-secondary-schoolchildren-in-western-switzerland
#19
Simone Ackermann, Anne Vuadens, Fabio Levi, Jean-Luc Bulliard
AIMS OF THE STUDY: Although solar overexposure during childhood and adolescence increases the risk of melanoma, determinants of sunburn and sun protective behaviours of Swiss children have scarcely been explored. We investigated sunburn occurrence and sun protective behaviours of schoolchildren in western Switzerland, the region with the highest incidence of melanoma in Europe. MATERIAL AND METHODS: Self-reported questionnaires were administered during regular classes to pupils in 5th (primary school, n = 431), 8th and 11th grades (secondary school, n = 837) in the 18 public schools of La Chaux-de-Fonds...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27878787/interdisciplinary-decision-making-and-treatment-of-intracranial-aneurysms-in-the-era-of-complementary-microsurgical-and-endovascular-techniques
#20
Serge Marbacher, Michael Diepers, Timo Kahles, Krassen Nedeltchev, Luca Remonda, Javier Fandino
Rupture of an intracranial aneurysm is a life-threatening event. Only one third of intracranial aneurysms rupture during a patient's lifetime. Accurate markers that predict which intracranial aneurysms rupture and which do not are currently lacking in routine clinical practice. Therefore, the treatment decision is a careful balance between the natural history of the intracranial aneurysm and the risk of intervention based on aneurysm- and patient-specific risk factors. Many of these risk factors are also used to determine the modality of intervention...
2016: Swiss Medical Weekly
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