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Swiss Medical Weekly

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https://www.readbyqxmd.com/read/29231236/relevance-of-the-cerebral-collateral-circulation-in-ischaemic-stroke-time-is-brain-but-collaterals-set-the-pace
#1
Simon Jung, Roland Wiest, Jan Gralla, Richard McKinley, Heinrich Mattle, David Liebeskind
Blood supply to the brain is secured by an extensive collateral circulation system, which can be divided into primary routes, i.e., the Circle of Willis, and secondary routes, e.g., collaterals from the external to the internal carotid artery and leptomeningeal collaterals. Collateral flow is the basis for acute stroke treatment, since neurones will only survive long enough to be rescued with reperfusion therapies if there is sufficient collateral flow. Poor collateral flow is associated with worse outcome and faster growth of larger infarcts in acute stroke treatment...
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29231235/the-perioperative-use-of-synthetic-and-biological-disease-modifying-antirheumatic-drugs-in-patients-with-rheumatoid-arthritis
#2
Gregory Fleury, Silvano Mania, Didier Hannouche, Cem Gabay
Disease-modifying antirheumatic drugs (DMARDs) have become essential treatments in the management of patients with inflammatory rheumatic diseases. Their use has resulted in a marked improvement of disease control and a limitation of joint damage, although some patients still require subsequent corrective or joint replacement surgery. Due to their immunosuppressive effects, some DMARDs are associated with an increased risk of infection. The aim of this review is to discuss the available literature on the management of DMARDs during the perioperative period, particularly in the case of orthopaedic surgery...
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29231234/feasibility-acceptability-and-effectiveness-of-integrated-care-for-copd-patients-a-mixed-methods-evaluation-of-a-pilot-community-based-programme
#3
Tania Carron, Pierre-Olivier Bridevaux, Karin Lörvall, Rachel Parmentier, Jean-Bernard Moix, Vincent Beytrison, Raymond Pernet, Constance Rey, Pierre-Yves Roberfroid, Prashant N Chhajed, Thomas Dieterle, Ladina Joos Zellweger, Malcolm Kohler, Sabrina Maier, David Miedinger, Robert Thurnheer, Pascal Urwyler, Jean-Marie Tschopp, Emilie Zuercher, Jörg Daniel Leuppi, Bernard Burnand, Isabelle Peytremann-Bridevaux
QUESTION UNDER STUDY: The aim of this study was to assess the feasibility, acceptability and effectiveness of a pilot COPD integrated care programme implemented in Valais, Switzerland. METHODS: The programme was adapted from the self-management programme Living Well with COPD, and included the following elements: self-management patient-education group sessions, telephone and medical follow-ups, multidisciplinary teams, training of healthcare professionals, and evidence-based COPD care...
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29231233/access-to-hepatitis-c-treatment-for-patients-in-drug-substitution-programmes-the-fight-is-far-from-over
#4
Francesco Negro, Liudmyla Maistat
No abstract text is available yet for this article.
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185256/reply-to-technical-comment-on-gawinecka-et-al-acute-aortic-dissection-pathogenesis-risk-factors-diagnosis
#5
Felix Schönrath, Joanna Gawinecka, Arnold von Eckardstein
No abstract text is available yet for this article.
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185255/informal-caregiving-work-privacy-conflict-and-burnout-among-health-professionals-in-switzerland-a-cross-sectional-study
#6
Nadine Häusler, Matthias Bopp, Oliver Hämmig
INTRODUCTION: Health professionals were found to have an elevated burnout risk compared to the general population. Some studies also reported more emotional exhaustion - a component of burnout - for health professionals with informal caregiving responsibilities for children (double-duty child caregivers) or adults (double-duty adult caregivers) or a combination of both (triple-duty caregivers) compared to health professionals without informal caregiving roles (formal caregivers). However, the potential mediating effect of the work-privacy conflict in this relationship as well as differences between occupational groups have not yet been studied in healthcare settings...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185254/technical-comment-on-biskup-e-et-al-oncological-patients-in-the-intensive-care-unit-prognosis-decision-making-therapies-and-end-of-life-care
#7
Silvio A Ñamendys-Silva
No abstract text is available yet for this article.
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185253/cost-effectiveness-of-sacubitril-valsartan-in-chronic-heart-failure-patients-with-reduced-ejection-fraction
#8
Zanfina Ademi, Alena M Pfeil, Elizabeth Hancock, David Trueman, Rola Haroun Haroun, Celine Deschaseaux, Matthias Schwenkglenks
AIMS: We aimed to assess the cost effectiveness of sacubitril/valsartan compared to angiotensin-converting enzyme inhibitors (ACEIs) for the treatment of individuals with chronic heart failure and reduced-ejection fraction (HFrEF) from the perspective of the Swiss health care system. METHODS: The cost-effectiveness analysis was implemented as a lifelong regression-based cohort model. We compared sacubitril/valsartan with enalapril in chronic heart failure patients with HFrEF and New York-Heart Association Functional Classification II-IV symptoms...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185252/multidrug-resistant-or-antimicrobial-resistant-pathogens-alternatives-to-new-antibiotics
#9
Anne-Sophie Brunel, Benoit Guery
For the last few decades, multidrug resistance has become an increasing concern for both Gram-positive and Gram-negative bacteria. The number of new molecules has dramatically decreased and antibiotic resistance is now a priority in the international community. Facing this new threat, a large number of new as well as "old" solutions are now being discussed in the medical community to propose an alternative to antibiotic treatments. A first option is to potentiate the effect of existing molecules through combinations to circumvent the individual molecule resistance...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185251/ultrasound-indications-for-maternal-storch-testing-in-pregnancy
#10
Cora Alexandra Voekt, Therese Rinderknecht, Hans Hellmuth Hirsch, Annette Blaich, Irene Mathilde Hösli
AIMS OF THE STUDY: Fetal abnormalities found on ultrasonography lead to a variety of diagnostic procedures, including a panel of serologies to detect possible maternal STORCH infections encompassing syphilis, Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex, and others (human immunodeficiency virus, hepatitis B and C, parvovirus B19, enterovirus, varicella zoster, and Leptospira interrogans). The value of indiscriminate testing for infections upon the detection of fetal ultrasound abnormalities has been questioned...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185250/management-of-hepatitis-c-in-decentralised-versus-centralised-drug-substitution-programmes-and-minimally-invasive-point-of-care-tests-to-close-gaps-in-the-hcv-cascade
#11
Andrea Bregenzer, Anna Conen, Jürg Knuchel, Andrée Friedl, Franz Eigenmann, Martin Näf, Peter Ackle, Martin Roth, Christoph Andreas Fux
BACKGROUND: In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programmes are often insufficiently screened and treated. AIM: The aim was to compare the current state of HCV management in centralised and decentralised drug substitution programmes of the canton Aargau...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185249/temporal-trends-of-postpartum-haemorrhage-in-switzerland-a-22-year-retrospective-population-based-cohort-study
#12
Andrea Kaelin Agten, Daniel Passweg, Stephanie von Orelli, Nancy Ringel, Ruedi Tschudi, Boris Tutschek
AIM: Postpartum haemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality. Studies have reported an increase in incidence of postpartum haemorrhage in recent years. Our goal was to investigate changes in the incidence of postpartum haemorrhage (PPH) and its risk factors in Switzerland from 1993 to 2014. METHODS: This population-based retrospective cohort study used data from the national Swiss Hospital in-patient database for obstetric and gynaecological hospital admissions - "Arbeitsgemeinschaft Schweizer Frauenkliniken" (ASF Statistik)...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185248/reply-to-technical-comment-on-biskup-e-et-al-oncological-patients-in-the-intensive-care-unit-prognosis-decision-making-therapies-and-end-of-life-care
#13
Ewelina Biskup, Fengfeng Cai, Marcus Vetter, Stephan Marsch
No abstract text is available yet for this article.
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185247/technical-comment-on-gawinecka-et-al-acute-aortic-dissection-pathogenesis-risk-factors-and-diagnosis
#14
Salah Dine Qanadli
No abstract text is available yet for this article.
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185246/is-there-a-role-for-procalcitonin-in-differentiating-uncomplicated-and-complicated-diverticulitis-in-order-to-reduce-antibiotic-therapy-a-prospective-diagnostic-cohort-study
#15
Victor Jeger, Roxana Pop, Farschad Forudastan, Jean Pierre Barras, Markus Zuber, Rein Jan Piso
AIMS OF THE STUDY: While studies show that antibiotic treatment for uncomplicated diverticulitis seems to have no benefit, most experts advocate antimicrobial therapy for complicated diverticulitis. However, even for uncomplicated diverticulitis, most clinicians are very reluctant to withhold antibiotics. Biomarkers could help to guide antibiotic therapy as this approach has been shown to be effective for acute respiratory infections. In this diagnostic cohort study we evaluated whether procalcitonin could be a biomarker to distinguish complicated from uncomplicated cases of diverticulitis...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185245/hpv-negative-cin3-and-cervical-cancer-in-switzerland-any-evidence-of-impact-on-screening-policies
#16
Pierre Vassilakos, Phuong Lien Tran, Roland Sahli, Nicola Low, Patrick Petignat
No abstract text is available yet for this article.
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185244/monobodies-as-possible-next-generation-protein-therapeutics-a-perspective
#17
Oliver Hantschel
Over the past two decades, hundreds of new somatic mutations have been identified in tumours, and a few dozen novel cancer therapeutics that selectively target these mutated oncoproteins have entered clinical practice. This development has resulted in clinical breakthroughs for a few tumour types, but more commonly patients' overall survival has not improved because of the development of drug resistance. Furthermore, only a very limited number of oncoproteins, largely protein kinases, are successfully targeted, whereas most non-kinase oncoproteins inside cancer cells remain untargeted...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185243/risk-of-adverse-outcome-in-patients-referred-by-emergency-medical-services-in-switzerland
#18
Tito Bosia, Alexandra Malinovska, Karin Weigel, Fabrizia Schmid, Christian Hans Nickel, Roland Bingisser
AIMS OF THE STUDY: Comparison of outcomes between different emergency medical services (EMS) is difficult and lacking in Switzerland. Therefore, knowledge about the inherent risks of EMS-referred patients is important. Targeted interventions may benefit these patients by optimising resource allocation. We therefore aimed to study outcomes in EMS-referred patients presenting to a Swiss emergency department (ED). METHODS: Prospective observational study in all patients presenting to the ED of Basel University Hospital...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185242/costs-and-benefits-of-diagnostic-testing-four-ways-to-improve-patient-care-by-purposive-use-of-in-vitro-diagnostics
#19
Carmen Binder, Maximilian Schmid, Thomas Dieterle, Hans Hendrik Schäfer
Scientific advances and innovative targeted drugs, especially biologics, have revolutionised the treatment of many diseases. In oncology in particular, previously acute or lethal conditions have come to be considered chronic as new treatments have led to longer life expectancies and a lower rate of years lived with disability. These advances, however, come with rising costs in a resource-constrained environment. To achieve cost containment, reimbursement for in-vitro diagnostics (IVDs) is increasingly coming under pressure because they are perceived as a cost factor rather than as a tool to reduce expenditure in the long term...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29185241/quality-indicators-of-colorectal-cancer-care-in-southern-switzerland-results-from-a-population-based-study
#20
Alessandra Spitale, Laura Ortelli, Luca Mazzucchelli, Andrea Bordoni
AIM OF THE STUDY: Assessing the quality of cancer care (QoCC) has become increasingly relevant to providers, regulators and purchasers of healthcare worldwide. The aim of this study was to assess adherence to validated quality indicators (QIs) for colorectal cancer (CRC) in a population-based setting, and to compare results with the available literature. METHODS: All colorectal cancers diagnosed between 1 January 2011 and 31 December 2012 were identified from the files of the population-based Ticino Cancer Registry, southern Switzerland...
November 29, 2017: Swiss Medical Weekly
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