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Swiss Medical Weekly

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https://www.readbyqxmd.com/read/29964292/excipients-not-so-inert-when-the-excipient-plays-the-role-of-an-active-substance-as-exemplified-by-systemic-lupus
#1
Sylviane Muller
It is well recognised that the historical timeline required for developing a drug, beginning with target identification and validation, is long and often tedious. It requires a large set of competences in various areas of molecular and cellular biology, chemistry, pharmacology, imaging, and model animal experimentation. Once the active molecule appears to be ready for human testing in controlled clinical trials, then the question arises of how to formulate it to render it stable, adequately packaged, according to the chosen route of administration, and bioavailable to reach its target in the affected organs...
June 25, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29964291/look-before-you-sprint-look-at-the-data-and-look-at-the-consequences
#2
Alain Nordmann, Mike Fernandes, Marcel G M Olde Rikkert
No abstract text is available yet for this article.
June 25, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29894556/adaptation-of-cost-effectiveness-analyses-to-a-single-country-the-case-of-bariatric-surgery-for-obesity-and-overweight
#3
Zanfina Ademi, Yuki Tomonaga, Joris van Stiphout, Dominik Glinz, Viktoria Gloy, Heike Raatz, Heiner C Bucher, Matthias Schwenkglenks
OBJECTIVES: The aims of this study were to (a) identify and assess the quality of reporting of published cost-effectiveness studies of bariatric surgery, (b) assess their transferability to Switzerland, and (c) adapt transferable cost-effectiveness results to Switzerland. METHODS: A systematic literature search was performed in Medline, Embase and other databases. Two reviewers independently undertook screening, extraction, assessment of reporting quality utilising the Consolidated Health Economic Evaluation Reporting Standards, transferability, adaptation of cost data and recalculation of cost-effectiveness results...
June 12, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29894555/clinical-characteristics-audiological-and-neurodevelopmental-outcomes-of-newborns-with-congenital-cytomegalovirus-infection
#4
Manuela Kobas, Myriam Bickle Graz, Anita Carmen Truttmann, Eric Giannoni, Pascal Meylan, Sandra Andrea Asner
BACKGROUND: Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown. AIMS OF THE STUDY: (1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection...
June 12, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29767828/a-digitally-facilitated-citizen-science-driven-approach-accelerates-participant-recruitment-and-increases-study-population-diversity
#5
Milo A Puhan, Nina Steinemann, Christian P Kamm, Stephanie Müller, Jens Kuhle, Roland Kurmann, Pasquale Calabrese, Jürg Kesselring, Viktor von Wyl, Swiss Multiple Sclerosis Registry Smsr
QUESTION UNDER STUDY: Our aim was to assess whether a novel approach of digitally facilitated, citizen-science research, as followed by the Swiss Multiple Sclerosis Registry (Swiss MS Registry), leads to accelerated participant recruitment and more diverse study populations compared with traditional research studies where participants are mostly recruited in study centres without the use of digital technology. METHODS: The Swiss MS Registry is a prospective, longitudinal, observational study covering all Switzerland...
May 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29767827/directing-citizens-to-create-advance-directives
#6
Sophie Haesen, David Shaw
This article describes the Swiss law on advance directives that was passed at the beginning of 2013 and led to more certainty about the legally binding character of such directives. However, for various reasons the drafting of advance directives is not yet widespread in Switzerland, and many resources might be put to better use if this became a common practice. A recent proposal by members of a political party to make the discussion, although not the actual drafting, of advance directives mandatory was rejected by the Swiss Federal Parliament, and the proposal was written off after having been pending for 2 years...
May 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29767826/accidental-or-intentional-exposure-to-potentially-toxic-medications-natural-toxins-and-chemicals-during-pregnancy-analysis-of-data-from-tox-info-suisse
#7
Tabea Vogel, Saskia Lüde, Rahel Baumgartner, Christine Rauber-Lüthy, Ana Paula Simões-Wüst
OBJECTIVE: Affected women and health professionals are still often unsure about how to react to exposures to potentially harmful agents during pregnancy. We wanted to find out which agents worry both pregnant women and professionals, under what circumstances the exposures take place, how they are currently dealt with and how serious they are. METHODS: Making use of the archives of Tox Info Suisse, the foundation that provides poisons information in Switzerland both for members of the general public and for healthcare professionals, we set up an analysis of exposures to possibly harmful agents during pregnancy...
May 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29756635/trends-in-the-use-of-mammography-for-early-breast-cancer-detection-in-switzerland-swiss-health-surveys-2007-and-2012
#8
Lukas Fenner, Anja Kässner, Claudia Berlin, Matthias Egger, Marcel Zwahlen
AIMS: Breast cancer is the most common cancer in women worldwide. We assessed changes in the use of breast cancer screening 2007-2012 in Switzerland, and associations with socioeconomic and health-related determinants. METHODS: We used the nationwide and representative data from the Swiss Health Surveys 2007 and 2012. We analysed the self-reported use of mammography in the last 12 months (proportion of population) among women aged 40-79 years, and opportunistic (without clinical symptoms, initiated by the woman or a physician) and programmatic screening mammography (as part of a systematic screening programme)...
May 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29756634/external-validation-of-the-80-score-and-comparison-with-three-clinical-scores-identifying-patients-at-least-75-years-old-at-risk-of-unplanned-readmission-within-30-days-after-discharge
#9
Camille Schwab, Alexis Le Moigne, Christine Fernandez, Pierre Durieux, Brigitte Sabatier, Virginie Korb-Savoldelli
AIM OF THE STUDY: A potentially avoidable readmission is an unplanned readmission occurring within 30 days of discharge. As 20% of hospitalised elderly patients are rehospitalised as an unplanned readmission, it is necessary to identify with a clinical score those patients who are at risk of readmission and need discharge interventions as a priority. The main objective of this study was to externally validate and compare the 80+ score with the three other scores predicting the risk of unplanned readmission...
May 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29756633/immunotherapy-in-head-and-neck-cancer-scientific-rationale-current-treatment-options-and-future-directions
#10
Uta Rothschild, Laurent Muller, Axel Lechner, Hans A Schlösser, Dirk Beutner, Heinz Läubli, Alfred Zippelius, Sacha I Rothschild
Head and neck squamous cell carcinoma (HNSCC) is a frequent tumour arising from multiple anatomical subsites in the head and neck region. The treatment for early-stage disease is generally single modality, either surgery or radiotherapy. The treatment for locally advanced tumours is multimodal. For recurrent/metastatic HNSCC palliative chemotherapy is standard of care. The prognosis is limited and novel treatment approaches are urgently needed. HNSCC evades immune responses through multiple resistance mechanisms...
May 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698548/the-place-of-the-ozaki-procedure-in-the-treatment-of-aortic-valve-disease
#11
Tornike Sologashvili, René Prêtre
No abstract text is available yet for this article.
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698547/first-case-of-candida-auris-in-switzerland-discussion-about-preventive-strategies
#12
Arnaud Riat, Dionysios Neofytos, Alix Coste, Stephan Harbarth, Alain Bizzini, Bruno Grandbastien, Jerome Pugin, Frederic Lamoth
No abstract text is available yet for this article.
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698546/the-epidemiology-of-hepatitis-c-in-switzerland-trends-in-notifications-1988-2015
#13
Jean-Luc Richard, Christian Schaetti, Sabine Basler, Mirjam Mäusezahl
With an estimated antibody prevalence of 0.7% in the low-risk population, hepatitis C virus (HCV) endemicity in Switzerland is low. We reviewed data from mandatory hepatitis C surveillance for 1988-2015 in order to describe the evolution of acute HCV infections and newly reported non-acute cases, and their epidemiological features. Crude and stratified annual incidence and notification rates and rate ratios were calculated using Poisson regression. Acute HCV incidence peaked in 2002 at 1.8 cases per 100,000 population, then declined sharply, levelling at around 0...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698545/the-role-of-molecular-imaging-in-assessing-degenerative-parkinsonism-an-updated-review
#14
Nicolas Nicastro, Valentina Garibotto, Pierre R Burkhard
Diagnosing degenerative forms of parkinsonism still relies on a thorough clinical assessment, which in Parkinson's disease involves the presence of an asymmetric bradykinesia with rest tremor and/or rigidity that respond substantially to levodopa. Conversely, atypical forms, including multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, exhibit additional features (cerebellar or pyramidal signs, early postural instability), a poor response to dopamine replacement therapy and a bad prognosis...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698544/the-swiss-cystic-fibrosis-infant-lung-development-scild-cohort
#15
Insa Korten, Elisabeth Kieninger, Sophie Yammine, Nicolas Regamey, Sylvia Nyilas, Kathryn Ramsey, Carmen Casaulta, Philipp Latzin, For The Scild Study Group
The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort is a prospective birth cohort study investigating the initiating events of cystic fibrosis lung disease during infancy, and their influence on the trajectory of disease progression throughout early childhood. Infants with cystic fibrosis are recruited throughout Switzerland after diagnosis by new-born screening. It is the first European population-based prospective cohort study of infants with cystic fibrosis taking advantage of a nationwide new-born screening programme...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698543/clinical-course-and-prevalence-of-coercive-measures-an-observational-study-among-involuntarily-hospitalised-psychiatric-patients
#16
Florian Hotzy, Sonja Moetteli, Anastasia Theodoridou, Andres Ricardo Schneeberger, Erich Seifritz, Paul Hoff, Matthias Jäger
AIMS OF THE STUDY: In daily clinical work, coercion continues to be highly prevalent, with rates differing between countries and sometimes even within countries or between wards of the same hospital. Previous research found inconsistent characteristics of individuals who underwent coercive measures during psychiatric treatment. Furthermore, there continues to be a lack of knowledge on the clinical course of people after being involuntarily committed. This study aimed to describe the rate and duration of different coercive measures and characterise a cohort of involuntarily committed patients regarding sociodemographic and clinical variables...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698542/point-prevalence-of-healthcare-associated-infections-and-antibiotic-use-in-three-large-swiss-acute-care-hospitals
#17
Aliki Metsini, Miriam Vazquez, Rami Sommerstein, Jonas Marschall, Cathy Voide, Nicolas Troillet, Céline Gardiol, Didier Pittet, Walter Zingg, The Swissnoso Network
BACKGROUND: The overall burden of healthcare-associated infections (HAIs) remains high, even in high-income countries. However, the current burden of HAI in Switzerland is unknown. Prevalence surveys have a long tradition in the field of infection prevention and control for measuring both HAI and antimicrobial use. The objective of this survey was to test the point prevalence survey (PPS) methodology of the European Centre for Disease Prevention and Control (ECDC) in acute-care hospitals in Switzerland...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698541/occupational-exposure-to-plant-protection-products-and-health-effects-in-switzerland-what-do-we-know-and-what-do-we-need-to-do
#18
Halshka Graczyk, Nancy B Hopf, Zakia Mediouni, Irina Guseva-Canu, Olivier Sanvido, Kaspar Schmid, Aurelie Berthet
AIMS: There is currently no centralised database on workers' exposures to plant protection products (PPPs) in Switzerland, nor a national register for negative health effects linking them to occupational PPP exposure. This lack of basic data makes it difficult to implement either epidemiological research or prevention campaigns for the agricultural sector. The first objective was to understand the level of information and flow of data on occupational PPP exposures and health effects in the Canton of Vaud, Switzerland...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29698540/the-impact-of-clinical-trial-units-on-the-value-of-clinical-research-in-switzerland
#19
Belinda von Niederhäusern, Annette Magnin, Christiane Pauli-Magnus
A prominent 2014 series by The Lancet on "Increasing value, reducing waste in biomedical research" provided recommendations on how to optimise precious resources, including in clinical research. Despite being ideally placed to lead the movement in patient-oriented clinical research, academia struggles to take corresponding measures and find ways to evaluate their impact. A decade ago, Swiss stakeholders established constructive initiatives to improve the quality of clinical research, including a national Clinical Trial Unit (CTU) Network, predominantly rooted in university hospitals...
April 26, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29694646/impairment-of-chondrocyte-proliferation-after-exposure-of-young-murine-cartilage-to-an-aged-systemic-environment-in-a-heterochronic-parabiosis-model
#20
Lu Li, Xiaochun Wei, Xiang Geng, Zhiqing Duan, Xiaohu Wang, Pengcui Li, Chunfang Wang, Lei Wei
AIM: The aim of this study was to investigate whether an aged systemic environment could impair young cartilage tissue in mice. METHODS: Mice differing in age were randomly divided into three groups. Group 1 was the experimental group (Y/O group) consisting of the heterochronic parabiosis model (2-month-old/12-month-old, young/old). Group 2 was the surgical control group (Y/Y group) with the isochronic parabiosis model (2-month-old/2-month-old, young/young). Group 3 consisted of the ageing control mice (2-month-old alone, Y group)...
April 25, 2018: Swiss Medical Weekly
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