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Swiss Medical Weekly

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https://www.readbyqxmd.com/read/29452426/open-access-data-capitalism-and-academic-publishing
#1
Michael Hagner
Open Access (OA) is widely considered a breakthrough in the history of academic publishing, rendering the knowledge produced by the worldwide scientific community accessible to all. In numerous countries, national governments, funding institutions and research organisations have undertaken enormous efforts to establish OA as the new publishing standard. The benefits and new perspectives, however, cause various challenges. This essay addresses several issues, including that OA is deeply embedded in the logic and practices of data capitalism...
February 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29451946/first-experience-in-switzerland-in-phe508del-homozygous-cystic-fibrosis-patients-with-end-stage-pulmonary-disease-enrolled-in-a-lumacaftor-ivacaftor-therapy-trial-preliminary-results
#2
Christian Murer, Lars Christian Huber, Thomas Kurowski, Astrid Hirt, Cécile A Robinson, Urs Bürgi, Christian Benden
AIMS OF THE STUDY: Cystic fibrosis is the most common genetic disorder in Caucasians. The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector lumacaftor / potentiator ivacaftor (LUM/IVA) has been shown to increase forced expiratory volume in 1 second (FEV1) moderately, but predominantly reduce acute exacerbation rate (AER) in Phe508del homozygous cystic fibrosis patients; however, patients with FEV1 <40% predicted were excluded from studies. We used LUM/IVA on a "compassionate use" basis in cystic fibrosis patients with end-stage pulmonary disease...
February 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442345/craniopharyngioma-a-chronic-disease
#3
Hermann Müller
No abstract text is available yet for this article.
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442344/comparison-of-essdai-and-clinessdai-in-potential-optimisation-of-trial-outcomes-in-primary-sj%C3%A3-gren-s-syndrome-examination-of-data-from-the-uk-primary-sj%C3%A3-gren-s-syndrome-registry
#4
Alexandre Dumusc, Wan-Fai Ng, Katherine James, Bridget Griffiths, Elizabeth Price, Colin Pease, Paul Emery, Peter Lanyon, Adrian Jones, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, Monica Gupta, John McLaren, Annie Cooper, Ian Giles, David Isenberg, Vadivelu Saravanan, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young-Min, Robert Moots, Nagui Gendi, Mohammed Akil, Francesca Barone, Benjamin Fisher, Saaeha Rauz, Andrea Richards, Simon Bowman
OBJECTIVES: To assess the use of the Clinical EULAR Sjögren's Syndrome Disease Activity Index (ClinESSDAI), a version of the ESSDAI without the biological domain, for assessing potential eligibility and outcomes for clinical trials in patients with primary Sjögren's syndrome (pSS), according to the new ACR-EULAR classification criteria, from the UK Primary Sjögren's Syndrome Registry (UKPSSR). METHODS: A total of 665 patients from the UKPSSR cohort were analysed at their time of inclusion in the registry...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442343/diet-medication-use-and-drug-intake-during-pregnancy-data-from-the-swiss-health-surveys-2007-and-2012
#5
Antonios Koutelidakis
No abstract text is available yet for this article.
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442342/a-ten-year-follow-up-study-of-treatment-outcome-of-craniopharyngiomas
#6
Lukas Andereggen, Benjamin Hess, Robert Andres, Marwan El-Koussy, Luigi Mariani, Andreas Raabe, Rolf W Seiler, Emanuel Christ
PURPOSE: Craniopharyngioma-related hypothalamic obesity is a devastating complication with limited data on whether long-term follow-up should focus on problems other than endocrine deficiencies and weight gain. The primary endpoint was the assessment of predictors of hypothalamic obesity development; the secondary endpoint was the assessment of functional outcome (endocrine deficiencies, visual acuity) at long-term follow-up. METHODS: This retrospective case-note study examined craniopharyngioma patients with at least 2 years of follow-up...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442341/the-influence-of-hospitalisation-on-the-initiation-continuation-and-discontinuation-of-benzodiazepines-and-z-drugs-an-observational-study
#7
Thomas Grimmsmann, Markus Harden, Thomas Fiß, Wolfgang Himmel
BACKGROUND AND OBJECTIVES: Hospitalisation influences drug therapy in ambulatory care and this influence is generally negatively perceived. The few studies that have explored changes in benzodiazepine or sleep medication use as a function of hospitalisation failed to precisely determine the hospital's role in initiating, continuing and discontinuing these drugs on a valid basis. The aim of the study was to ascertain the overall influence of hospitalisation on the prescription of benzodiazepines and Z-drugs in outpatient care with a special focus on the role of different hospital departments and drug classes...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29442340/aortic-valve-replacement-using-autologous-pericardium-single-centre-experience-with-the-ozaki-technique
#8
Oliver Reuthebuch, Luca Koechlin, Ulrich Schurr, Martin Grapow, Jens Fassl, Friedrich S Eckstein
OBJECTIVE: To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD: Between September 2015 and May 2017 30 patients (20 males, mean ± standard deviation age 66.83 ± 10.55 years) suffering from aortic stenosis (AS, n = 7), aortic regurgitation (AR, n = 12), or a combination of both (AS/AR, n = 11) were assigned for an Ozaki procedure...
February 14, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376558/funding-characteristics-of-randomised-clinical-trials-supported-by-the-swiss-national-science-foundation-a-retrospective-cohort-study
#9
Alain Amstutz, Stefan Schandelmaier, Roy Frei, Jakub Surina, Arnav Agarwal, Reem Alturki, Belinda von Niederhäusern, Erik von Elm, Matthias Briel, On Behalf Of The MAking Randomized Trials Affordable Marta Group
AIMS OF THE STUDY: Failure to publish publicly funded research represents a waste of scarce research resources across medical disciplines and countries. In Switzerland, about 40% of randomised clinical trials (RCTs) supported by the Swiss National Science Foundation (SNSF) were not published. We aimed to describe funding characteristics of published and unpublished RCTs supported by the SNSF, to quantify the amount of money spent for unpublished studies, and to compare our results to a similar study performed in the UK...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376557/excellent-outcome-of-direct-antiviral-treatment-for-chronic-hepatitis-c-in-switzerland
#10
Jacqueline Bachofner, Piero V Valli, Irina Bergamin, Arne Kröger, Patrizia Künzler, Adriana Baserga, Dominique L Braun, Burkhardt Seifert, Anja Moncsek, Jan Fehr, David Semela, Lorenzo Magenta, Beat Müllhaupt, Benedetta Terziroli Beretta-Piccoli, Joachim Mertens, The Swiss Hepatitis C Cohort Study
BACKGROUND: The introduction of direct acting antivirals (DAAs) for the therapy of chronic hepatitis C (CHC) has revolutionised treatment and marks a paradigm shift in the approach to this disease, rendering interferon-based therapies obsolete. AIMS OF THE STUDY: We retrospectively and prospectively evaluated treatment results after the introduction of DAA in Switzerland in a cohort of patients with CHC. METHODS: We examined 565 patients who received DAA treatment for CHC between November 2013 and June 2016 with regard to HCV genotype, fibrosis stadium, treatment and outcome...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376556/computed-tomography-imaging-for-the-characterisation-of-drugs-with-radiation-density-measurements-and-hu-spectroscopy
#11
Dominik A Sieron, Moritz Steib, Dominik Suter, Verena C Obmann, Adrian T Huber, Lukas Ebner, Daniel Inderbitzin, Andreas Christe
AIMS OF THE STUDY: To investigate the computed tomography (CT) density of frequently administered medications (1) for the better characterisation of substances on abdominal CT, (2) to allow radiologists to narrow down possibilities in the identification of hyperdense material in the bowel and (3) to provide forensic doctors with a tool to identify gastric contents before an autopsy. MATERIAL AND METHODS: From the list of the local hospital pharmacy, the 50 most frequently used medications were identified and scanned twice with a 128 row CT scanner (Acquillion, Toshiba, Tokyo, Japan)...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376555/reply-to-technical-comment-on-g%C3%A3-ller-et-al-lower-hospital-volume-is-associated-with-higher-mortality-after-oesophageal-gastric-pancreatic-and-rectal-cancer-resection
#12
Ulrich Güller, Rene Warschkow, Christoph Jakob Ackermann, Bruno M Schmied, Thomas Cerny, Silvia Ess
No abstract text is available yet for this article.
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376554/evaluation-of-the-frequency-of-adrenal-crises-and-preventive-measures-in-patients-with-primary-and-secondary-adrenal-insufficiency-in-switzerland
#13
Antje Notter, Stefan Jenni, Emanuel Christ
AIMS OF THE STUDY: Adrenal insufficiency is a dangerous clinical condition, leading to significant morbidity or mortality in situations with inadequate glucocorticoid replacement treatment. We aimed to assess preventive measures in adrenal insufficiency and the incidence and risk factors of adrenal crisis, as well as to test the patients' knowledge about their disease. METHODS: All patients in May and June 2016 and December 2016 and January 2017 with primary (17...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376553/do-late-preterm-twins-face-an-increased-neonatal-morbidity-compared-with-singletons
#14
Jarmila A Zdanowicz, Eliane Sommer, Luigi Raio, Mathias Nelle, Roland Gerull
OBJECTIVE: Late preterm infants (born between 34 0/7 and 36 6/7 weeks of gestation) have been shown to have a higher morbidity and mortality than term infants. Furthermore, twins, both term and preterm, have a higher neonatal morbidity than singletons. The aim of our study was to examine if late preterm twins consequently have twice the neonatal morbidity when both risk factors prematurity and multiple pregnancy are present. STUDY DESIGN: A retrospective single-centre study was conducted to compare neonatal outcome of late preterm singletons and late preterm twins born between 34 0/7 and 36 6/7 weeks of gestation as well as term twins with a gestational age from 37 0/7 to 41 6/7 weeks...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376552/impact-of-a-fracture-liaison-service-on-patient-management-after-an-osteoporotic-fracture-the-chuv-fls
#15
Bérengère Aubry-Rozier, Delphine Stoll, Elena Gonzalez Rodriguez, Didier Hans, Veronique Prudent, Ariane Seuret, Alain Farron, Olivier Lamy
In 2008, the Centre Hospitalier Universitaire Vaudois (CHUV, Lausanne, Switzerland) initiated a Fracture Liaison Service (FLS). All patients hospitalised for a low trauma fracture are identified by the FLS. Inpatients then choose to be managed by either the FLS team or their general practitioner (GP). In this study we compared the management between the FLS team and the GP in terms of diagnosis of osteoporosis, treatment, refracture rates and mortality after FLS recording. Results are compared with the management of osteoporosis before the creation of the FLS, as reported in the survey study Osteocare...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376551/availability-and-accessibility-of-perinatal-data-for-the-robson-classification-of-caesarean-sections-in-switzerland
#16
Susanne Grylka-Baeschlin, Thomas H Hess, Rebekka Erdin, Elke Prentl, Jessica Pehlke-Milde
No abstract text is available yet for this article.
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376550/preventing-hiv-transmission-through-blockade-of-ccr5-rationale-progress-and-perspectives
#17
Oliver Hartley, Elsa Martins, Ilaria Scurci
Of the two million people estimated to be newly infected with human immunodeficiency virus (HIV) every year, 95% live in poorer regions of the world where effective HIV treatment is not universally available. Strategies to reduce the spread of HIV infection, which predominantly occurs via sexual contact, are urgently required. In the absence of an effective vaccine, a number of approaches to prevent HIV infection have been developed. These include using potent anti-HIV drugs prophylactically, either through systemic administration or topical application to the mucosal tissues that HIV initially encounters during sexual transmission...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376549/technical-comment-on-g%C3%A3-ller-et-al-lower-hospital-volume-is-associated-with-higher-mortality-after-oesophageal-gastric-pancreatic-and-rectal-cancer-resection
#18
https://www.readbyqxmd.com/read/29376548/vitamin-d-levels-in-swiss-breast-cancer-survivors
#19
Michael Baumann, Sergio Ulhoa Dani, Daniel Dietrich, Andreas Hochstrasser, Dirk Klingbiel, Michael Thomas Mark, Walter F Riesen, Thomas Ruhstaller, Arnoud J Templeton, Beat Thürlimann
BACKGROUND: Cholecalciferol (vitamin D3) is widely supplemented in breast cancer survivors because of the role of vitamin D in multiple health outcomes. METHODS: We conducted an observational study in 332 women in Eastern Switzerland with early, i.e., nonmetastatic breast cancer. Tumour-, patient-related and sociodemographic variables were recorded. Cholecalciferol intake and serum 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were measured at the first visit (baseline) and during a follow-up visit in a median of 210 days (range 87-857) after the first visit...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29376547/digital-health-meeting-the-ethical-and-policy-challenges
#20
Effy Vayena, Tobias Haeusermann, Afua Adjekum, Alessandro Blasimme
Digital health encompasses a wide range of novel digital technologies related to health and medicine. Such technologies rely on recent advances in the collection and analysis of ever increasing amounts of data from both patients and healthy citizens. Along with new opportunities, however, come new ethical and policy challenges. These range from the need to adapt current evidence-based standards, to issues of privacy, oversight, accountability and public trust as well as national and international data governance and management...
January 29, 2018: Swiss Medical Weekly
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