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Biochemistry and Molecular Biology Education

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https://www.readbyqxmd.com/read/28681994/creating-3d-physical-models-to-probe-student-understanding-of-macromolecular-structure
#1
A Kat Cooper, M T Oliver-Hoyo
The high degree of complexity of macromolecular structure is extremely difficult for students to process. Students struggle to translate the simplified two-dimensional representations commonly used in biochemistry instruction to three-dimensional aspects crucial in understanding structure-property relationships. We designed four different physical models to address student understanding of electrostatics and noncovalent interactions and their relationship to macromolecular structure. In this study, we have tested these models in classroom settings to determine if these models are effective in engaging students at an appropriate level of difficulty and focusing student attention on the principles of electrostatic attractions...
July 6, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28670831/varying-iron-release-from-transferrin-and-lactoferrin-proteins-a-laboratory-experiment
#2
Fernando Carmona, Ana González, Manu Sánchez, Natividad Gálvez, Rafael Cuesta, Mercè Capdevila, Jose M Dominguez-Vera
Iron metabolism is an important subject of study for undergraduate students of chemistry and biochemistry. Relevant laboratory exercises are scarce in the literature but would be very helpful in assisting students grasp key concepts. The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf). Despite having very similar structures and iron-binding sites, Tf releases practically all its iron at pH 5.5 while Lf requires a significantly lower pH of 3...
July 3, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28665030/idea-worthy-to-explore-connecting-global-and-local-in-teaching-about-diseases
#3
EDITORIAL
Susan A White
No abstract text is available yet for this article.
June 30, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28627731/cell-migration-analysis-a-low-cost-laboratory-experiment-for-cell-and-developmental-biology-courses-using-keratocytes-from-fish-scales
#4
Daniel Prieto, Gonzalo Aparicio, Jose R Sotelo-Silveira
Cell and developmental processes are complex, and profoundly dependent on spatial relationships that change over time. Innovative educational or teaching strategies are always needed to foster deep comprehension of these processes and their dynamic features. However, laboratory exercises in cell and developmental biology at the undergraduate level do not often take into account the time dimension. In this article, we provide a laboratory exercise focused in cell migration, aiming to stimulate thinking in time and space dimensions through a simplification of more complex processes occurring in cell or developmental biology...
June 19, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28621449/a-flexible-e-learning-resource-promoting-the-critical-reading-of-scientific-papers-for-science-undergraduates
#5
Julie Letchford, Hazel Corradi, Trevor Day
An important aim of undergraduate science education is to develop student skills in reading and evaluating research papers. We have designed, developed, and implemented an on-line interactive resource entitled "Evaluating Scientific Research literature" (ESRL) aimed at students from the first 2 years of the undergraduate program. In this article, we describe the resource, then use student data collected from questionnaire surveys to evaluate the resource within 2 years of its launch. Our results add to those reported previously and indicate that ESRL can enable students to start evaluating research articles when used during their undergraduate program...
June 16, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28581156/the-usability-of-wechat-as-a-mobile-and-interactive-medium-in-student-centered-medical-teaching
#6
Juan Wang, Furong Gao, Jiao Li, Jieping Zhang, Siguang Li, Guo-Tong Xu, Lei Xu, Jianjun Chen, Lixia Lu
Biochemistry and cellular biology courses for medical students at Tongji University include the assessment that provides students with feedback to enhance their learning, which is a type of formative assessment. However, frequent instant feedback and guidance for students is often absent or inconsistently included in the teaching process. WeChat, the most popular Chinese social media, was introduced in biochemistry and cellular biology course. A WeChat official account (OA) was set up as an instant interactive platform...
June 5, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28544448/using-pymol-to-explore-the-effects-of-ph-on-noncovalent-interactions-between-immunoglobulin-g-and-protein-a-a-guided-inquiry-biochemistry-activity
#7
Zahilyn D Roche Allred, Heeyoung Tai, Stacey Lowery Bretz, Richard C Page
Students' understandings of foundational concepts such as noncovalent interactions, pH and pKa are crucial for success in undergraduate biochemistry courses. We developed a guided-inquiry activity to aid students in making connections between noncovalent interactions and pH/pKa . Students explore these concepts by examining the primary and tertiary structures of immunoglobulin G (IgG) and Protein A. Students use PyMOL, an open source molecular visualization application, to (1) identify hydrogen bonds and salt bridges between and within the proteins at physiological pH and (2) apply their knowledge of pH/pKa to association rate constant data for these proteins at pH 4 and pH 11...
May 24, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28544484/neglected-issues-concerning-teaching-human-adrenal-steroidogenesis-in-popular-biochemistry-textbooks
#8
Zhiyong Han, Mark S Elliott
In the human body, the adrenal steroids collectively regulate a plethora of fundamental functions, including electrolyte and water balance, blood pressure, stress response, intermediary metabolism, inflammation, and immunity. Therefore, adrenal steroidogenesis is an important biochemistry topic for students to learn in order for them to understand health consequences caused by deficiencies of enzymes in the adrenal steroidogenic pathways. However, popular biochemistry textbooks contain insufficient information and may sometimes give students a misimpression about certain aspects of human adrenal steroidogenesis...
May 19, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28520272/a-focus-on-polarity-investigating-the-role-of-orientation-cues-in-mediating-student-performance-on-mrna-synthesis-tasks-in-an-introductory-cell-and-molecular-biology-course
#9
Jeffrey T Olimpo, Daniel A Quijas, Anita M Quintana
The central dogma has served as a foundational model for information flow, exchange, and storage in the biological sciences for several decades. Despite its continued importance, however, recent research suggests that novices in the domain possess several misconceptions regarding the aforementioned processes, including those pertaining specifically to the formation of messenger ribonucleic acid (mRNA) transcripts. In the present study, we sought to expand upon these observations through exploration of the influence of orientation cues on students' aptitude at synthesizing mRNAs from provided deoxyribonucleic acid (DNA) template strands...
May 18, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696056/meetings-calendar
#10
(no author information available yet)
No abstract text is available yet for this article.
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696055/practices-and-exploration-on-competition-of-molecular-biological-detection-technology-among-students-in-food-quality-and-safety-major
#11
Yaning Chang, Yuke Peng, Pengfei Li, Yingping Zhuang
With the increasing importance in the application of the molecular biological detection technology in the field of food safety, strengthening education in molecular biology experimental techniques is more necessary for the culture of the students in food quality and safety major. However, molecular biology experiments are not always in curricula of Food quality and safety Majors. This paper introduced a project "competition of molecular biological detection technology for food safety among undergraduate sophomore students in food quality and safety major", students participating in this project needed to learn the fundamental molecular biology experimental techniques such as the principles of molecular biology experiments and genome extraction, PCR and agarose gel electrophoresis analysis, and then design the experiments in groups to identify the meat species in pork and beef products using molecular biological methods...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696054/undergraduate-research-as-curriculum
#12
EDITORIAL
Erin L Dolan
To date, national interests, policies, and calls for transformation of undergraduate education have been the main drivers of research integration into the undergraduate curriculum, briefly described here. The New Horizons in Biochemistry and Molecular Biology Education conference at the Weizmann Institute of Science (Israel) this fall presents an exciting opportunity to discuss integration of undergraduate research into the curriculum and other cutting-edge topics in biochemistry and molecular biology education from a cross-national perspective...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696053/learning-effectiveness-and-satisfaction-of-international-medical-students-introducing-a-hybrid-pbl-curriculum-in-biochemistry
#13
Qiu Yan, Li Ma, Lina Zhu, Wenli Zhang
A biochemistry course is a fundamental but important subject in medical education in China. In recent years, the number of international medical students has increased. Curriculum reform in biochemistry teaching is needed because of the knowledge limitations of students, a close linkage of biochemical content with clinics, the shortcomings of lecture-centered teaching, and the requirements for early clinical practice training and competence. In this study, we analyzed a novel curriculum reform, "Hybrid-PBL," which combined problem-based learning (PBL) with biochemistry lectures and was implemented for biochemical teaching at Dalian Medical University (DMU) in China...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28314074/better-understanding-of-homologous-recombination-through-a-12-week-laboratory-course-for-undergraduates-majoring-in-biotechnology
#14
Ming Li, Xiaodong Shen, Yan Zhao, Xiaomei Hu, Fuquan Hu, Xiancai Rao
Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis of homologous recombination. In this study, we developed and implemented a 12-week laboratory course for biotechnology undergraduates in which gene targeting in Streptococcus suis was used to facilitate their understanding of the basic concept and process of homologous recombination...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28230314/approaches-to-enhance-the-teaching-quality-of-experimental-biochemistry-for-mbbs-students-in-tsmu-china
#15
Lijuan Yu, Shuying Yi, Jing Zhai, Zhaojin Wang
With the internationalization of medical education in China, the importance of international students' education in medical schools is also increasing. Except foreign students majoring in Chinese language, English Bachelor of Medicine, Bachelor of Surgery (MBSS) students are the largest group of international students. Based on problems in the teaching process for experimental biochemistry, we designed teaching models adapted to the background of international students and strengthened teachers' teaching ability at Taishan Medical University...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28205321/an-investigative-graduate-laboratory-course-for-teaching-modern-dna-techniques
#16
Alexandre de Lencastre, A Thomas Torello, Lani C Keller
This graduate-level DNA methods laboratory course is designed to model a discovery-based research project and engages students in both traditional DNA analysis methods and modern recombinant DNA cloning techniques. In the first part of the course, students clone the Drosophila ortholog of a human disease gene of their choosing using Gateway(®) cloning. In the second part of the course, students examine the expression of their gene of interest in human cell lines by reverse transcription PCR and learn how to analyze data from quantitative reverse transcription PCR (qRT-PCR) experiments...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28145107/a-comprehensive-experiment-for-molecular-biology-determination-of-single-nucleotide-polymorphism-in-human-rev3-gene-using-pcr-rflp
#17
Xu Zhang, Meng Shao, Lu Gao, Yuanyuan Zhao, Zixuan Sun, Liping Zhou, Yongmin Yan, Qixiang Shao, Wenrong Xu, Hui Qian
Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of DNA polymerase ζ and SNPs in this gene are associated with altered susceptibility to cancer. This newly designed experiment is composed of three parts, including genomic DNA extraction, gene amplification by PCR, and genotyping by RFLP...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28145077/using-molecular-visualization-to-explore-protein-structure-and-function-and-enhance-student-facility-with-computational-tools
#18
Cassidy R Terrell, Laura L Listenberger
Recognizing that undergraduate students can benefit from analysis of 3D protein structure and function, we have developed a multiweek, inquiry-based molecular visualization project for Biochemistry I students. This project uses a virtual model of cyclooxygenase-1 (COX-1) to guide students through multiple levels of protein structure analysis. The first assignment explores primary structure by generating and examining a protein sequence alignment. Subsequent assignments introduce 3D visualization software to explore secondary, tertiary, and quaternary structure...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28145074/assessment-of-knowledge-of-participants-on-basic-molecular-biology-techniques-after-5-day-intensive-molecular-biology-training-workshops-in-nigeria
#19
J I Yisau, A O Adagbada, T Bamidele, M Fowora, B I C Brai, O Adebesin, M Bamidele, T Fesobi, F O Nwaokorie, A Ajayi, S I Smith
The deployment of molecular biology techniques for diagnosis and research in Nigeria is faced with a number of challenges, including the cost of equipment and reagents coupled with the dearth of personnel skilled in the procedures and handling of equipment. Short molecular biology training workshops were conducted at the Nigerian Institute of Medical Research (NIMR), to improve the knowledge and skills of laboratory personnel and academics in health, research, and educational facilities. Five-day molecular biology workshops were conducted annually between 2011 and 2014, with participants drawn from health, research facilities, and the academia...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28059472/promoting-active-learning-of-graduate-student-by-deep-reading-in-biochemistry-and-microbiology-pharmacy-curriculum
#20
Ren Peng
To promote graduate students' active learning, deep reading of high quality papers was done by graduate students enrolled in biochemistry and microbiology pharmacy curriculum offered by college of life science, Jiangxi Normal University from 2013 to 2015. The number of graduate students, who participated in the course in 2013, 2014, and 2015 were eleven, thirteen and fifteen, respectively. Through deep reading of papers, presentation, and group discussion in the lecture, these graduate students have improved their academic performances effectively, such as literature search, PPT document production, presentation management, specialty document reading, academic inquiry, and analytical and comprehensive ability...
July 8, 2017: Biochemistry and Molecular Biology Education
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