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Biochemistry and Molecular Biology Education

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https://www.readbyqxmd.com/read/27873457/using-yeast-to-determine-the-functional-consequences-of-mutations-in-the-human-p53-tumor-suppressor-gene-an-introductory-course-based-undergraduate-research-experience-in-molecular-and-cell-biology
#1
Daria S Hekmat-Scafe, Sara E Brownell, Patricia Chandler Seawell, Shyamala Malladi, Jamie F Conklin Imam, Veena Singla, Nicole Bradon, Martha S Cyert, Tim Stearns
The opportunity to engage in scientific research is an important, but often neglected, component of undergraduate training in biology. We describe the curriculum for an innovative, course-based undergraduate research experience (CURE) appropriate for a large, introductory cell and molecular biology laboratory class that leverages students' high level of interest in cancer. The course is highly collaborative and emphasizes the analysis and interpretation of original scientific data. During the course, students work in teams to characterize a collection of mutations in the human p53 tumor suppressor gene via expression and analysis in yeast...
November 22, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27862849/blog-construction-as-an-effective-tool-in-biochemistry-active-learning
#2
Estêvão Cubas Rolim, Julia Martins de Oliveira, Luana T Dalvi, Daniel C Moreira, Natasha Garcia Caldas, Felipe Fernandes Lobo, Démerson André Polli, Élida G Campos, Marcelo Hermes-Lima
To boost active learning in undergraduate students, they were given the task of preparing blogs on topics of clinical biochemistry. This "experiment" lasted for 12 teaching-semesters (from 2008 to 2013), and included a survey on the blogs' usefulness at the end of each semester. The survey (applied in the 2008-2010 period) used a Likert-like questionnaire with eight questions and a 1-to-6 scale, from "totally disagree" to "fully agree." Answers of 428 students were analyzed and indicated overall approval of the blog activity: 86% and 35% of the responses scored 4-to-6 and 6, respectively...
November 14, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27807934/semester-long-inquiry-based-molecular-biology-laboratory-transcriptional-regulation-in-yeast
#3
Peter M Oelkers
A single semester molecular biology laboratory has been developed in which students design and execute a project examining transcriptional regulation in Saccharomyces cerevisiae. Three weeks of planning are allocated to developing a hypothesis through literature searches and use of bioinformatics. Common experimental plans address a cell process and how three genes that encode for proteins involved in that process are transcriptionally regulated in response to changing environmental conditions. Planning includes designing oligonucleotides to amplify the putative promoters of the three genes of interest...
November 3, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27807926/holiday-songs-for-the-biologist
#4
Richard H Heineman
No abstract text is available yet for this article.
November 3, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27807923/modeling-of-dna-and-protein-organization-levels-with-cn3d-software
#5
Panagiotis K Stasinakis, Despoina Nicolaou
The molecular structure of living organisms and the complex interactions amongst its components are the basis for the diversity observed at the macroscopic level. Proteins and nucleic acids are some of the major molecular components, and play a key role in several biological functions, such as those of development and evolution. This article presents an educational, bioinformatics-based process, designed to enhance a better understanding of the structure of the above molecules. In addition, by using selected protein molecules, it attempts to clarify protein organization levels and how these are related with the structural and functional diversity, which define the biodiversity of living organisms at the macroscopic level...
November 3, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27801537/mutual-benefit-for-foreign-medical-students-and-chinese-postgraduates-a-mixed-team-based-learning-method-overcomes-communication-problems-in-hematology-clerkship
#6
Xianling Chen, Buyuan Chen, Xiaofan Li, Qingxiao Song, Yuanzhong Chen
Hematology is difficult for students to learn. A beneficial education method for hematology clerkship training is required to help students develop clinical skills. Foreign medical students often encounter communication issues in China. To address this issue, Chinese post-graduates from our institute are willing to assist with educating foreign students. Therefore, we propose a mixed team-based learning method (MTBL) which might overcome communication problems in hematology clerkship. Twenty-two foreign medical Students attended a 2-week hematology clerkship in Fujian Medical University Union Hospital...
November 1, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27740737/a-teaching-approach-from-the-exhaustive-search-method-to-the-needleman-wunsch-algorithm
#7
Zhongneng Xu, Yayun Yang, Beibei Huang
The Needleman-Wunsch algorithm has become one of the core algorithms in bioinformatics; however, this programming requires more suitable explanations for students with different major backgrounds. In supposing sample sequences and using a simple store system, the connection between the exhaustive search method and the Needleman-Wunsch algorithm was analyzed to more thoroughly explain this algorithm. The present study could benefit the teaching and learning of the Needleman-Wunsch algorithm. © 2016 by The International Union of Biochemistry and Molecular Biology, 2016...
October 14, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27677420/proteopedia-entry-g-protein-coupled-receptors
#8
R Jeremy Johnson, Jacob Applegarth, Steven Bennett, Sydney Caskey, Connor Coatney, Kurt Corsbie, Allison Cotter, Daniel Cotter, Alexis Coulis, Heather Hansen, Whitney Hart, Cutter Koehler, Andrew Koelper, Stephanie Kuhlman, Chandler Mitchell, Blake Moskal, Olivia Murfield, Allie Paton, Daniel Schemenauer, Brittany Stankavich, Clayton Taylor, Brent Waibel, L Dean Williams
No abstract text is available yet for this article.
September 28, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27677251/discovery-of-escherichia-coli-crispr-sequences-in-an-undergraduate-laboratory
#9
Kevin T Militello, Justine C Lazatin
Clustered regularly interspaced short palindromic repeats (CRISPRs) represent a novel type of adaptive immune system found in eubacteria and archaebacteria. CRISPRs have recently generated a lot of attention due to their unique ability to catalog foreign nucleic acids, their ability to destroy foreign nucleic acids in a mechanism that shares some similarity to RNA interference, and the ability to utilize reconstituted CRISPR systems for genome editing in numerous organisms. In order to introduce CRISPR biology into an undergraduate upper-level laboratory, a five-week set of exercises was designed to allow students to examine the CRISPR status of uncharacterized Escherichia coli strains and to allow the discovery of new repeats and spacers...
September 28, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27666950/mentor-mentee-interaction-and-laboratory-social-environment-do-they-matter-in-doctoral-students-publication-productivity
#10
Marcus Antonius Ynalvez, Ruby A Ynalvez, Enrique Ramírez
We explored the social shaping of science at the micro-level reality of face-to-face interaction in one of the traditional places for scientific activities-the scientific lab. We specifically examined how doctoral students' perception of their: (i) interaction with doctoral mentors (MMI) and (ii) lab social environment (LSE) influenced productivity. Construed as the production of peer-reviewed articles, we measured productivity using total number of articles (TOTAL), number of articles with impact factor greater than or equal to 4...
September 26, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27666748/a-laboratory-practical-illustrating-the-use-of-the-chip-qpcr-method-in-a-robust-model-estrogen-receptor-alpha-immunoprecipitation-using-mcf-7-culture-cells
#11
Eric Lacazette
Chromatin immunoprecipitation followed by qPCR analysis (ChIP-qPCR) is a widely used technique to study gene expression. A large number of students in molecular biology and more generally in life sciences will be confronted with the use of this technique, which is quite difficult to set up and can lead to misinterpretation if not carefully managed. This article describes a four-session laboratory practical designed for Masters students to introduce this technique. During the practical, students work in pairs...
September 26, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27666582/introducing-the-concept-of-biocatalysis-in-the-classroom-the-conversion-of-cholesterol-to-provitamin-d3
#12
Belén M De Luca, Clara B Nudel, Rodrigo H Gonzalez, Alejandro D Nusblat
Biocatalysis is a fundamental concept in biotechnology. The topic integrates knowledge of several disciplines; therefore, it was included in the course "design and optimization of biological systems" which is offered in the biochemistry curricula. We selected the ciliate tetrahymena as an example of a eukaryotic system with potential for the biotransformation of sterol metabolites of industrial interest; in particular, we focused on the conversion of cholesterol to provitamin D3. The students work with wild type and recombinant strains and learn how sterol pathways could be modified to obtain diverse sterol moieties...
September 26, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27613332/pop-it-beads-to-introduce-catalysis-of-reaction-rate-and-substrate-depletion-effects
#13
Austin U Gehret
A kinesthetic classroom activity was designed to help students understand enzyme activity and catalysis of reaction rate. Students served the role of enzymes by manipulating Pop-It Beads as the catalytic event. This activity illuminates the relationship between reaction rate and reaction progress by allowing students to experience first-hand the effect of substrate depletion on catalyzed reaction rate. Preliminary findings based on survey results and exam performance suggest the activity could prove beneficial to students in the targeted learning outcomes...
September 10, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27613202/turkish-university-students-knowledge-of-biotechnology-and-attitudes-toward-biotechnological-applications
#14
Ebru Öztürk-Akar
This study questions the presumed relation between formal schooling and scientific literacy about biotechnologies. Comparing science and nonscience majors' knowledge of and attitudes toward biotechnological applications, conclusions are drawn if their formal learnings improve pupils' understandings of and attitudes toward biotechnology applications. Sample of the study consists of 403 undergraduate and graduate students, 198 nonscience, and 205 science majors. The Biotechnology Knowledge Questionnaire and the Biotechnology Attitude Questionnaire were administered...
September 10, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27868390/meetings-calendar
#15
(no author information available yet)
No abstract text is available yet for this article.
November 12, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27292366/promoting-convergence-the-integrated-graduate-program-in-physical-and-engineering-biology-at-yale-university-a-new-model-for-graduate-education
#16
Dorottya B Noble, Simon G J Mochrie, Corey S O'Hern, Thomas D Pollard, Lynne Regan
In 2008, we established the Integrated Graduate Program in Physical and Engineering Biology (IGPPEB) at Yale University. Our goal was to create a comprehensive graduate program to train a new generation of scientists who possess a sophisticated understanding of biology and who are capable of applying physical and quantitative methodologies to solve biological problems. Here we describe the framework of the training program, report on its effectiveness, and also share the insights we gained during its development and implementation...
November 12, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27277577/connecting-common-genetic-polymorphisms-to-protein-function-a-modular-project-sequence-for-lecture-or-lab
#17
Christopher E Berndsen, Byron H Young, Quinlin J McCormick, Raymond A Enke
Single nucleotide polymorphisms (SNPs) in DNA can result in phenotypes where the biochemical basis may not be clear due to the lack of protein structures. With the growing number of modeling and simulation software available on the internet, students can now participate in determining how small changes in genetic information impact cellular protein structure and function. We have developed a modular series of activities to engage lab or lecture students in examining the basis for common phenotypes. The activities range from basic phenotype testing/observation to DNA sequencing and simulation of protein structure and dynamics...
November 12, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27241938/targeting-change-assessing-a-faculty-learning-community-focused-on-increasing-statistics-content-in-life-science-curricula
#18
Loran Carleton Parker, Alyssa M Gleichsner, Omolola A Adedokun, James Forney
Transformation of research in all biological fields necessitates the design, analysis and, interpretation of large data sets. Preparing students with the requisite skills in experimental design, statistical analysis, and interpretation, and mathematical reasoning will require both curricular reform and faculty who are willing and able to integrate mathematical and statistical concepts into their life science courses. A new Faculty Learning Community (FLC) was constituted each year for four years to assist in the transformation of the life sciences curriculum and faculty at a large, Midwestern research university...
November 12, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27229632/integration-of-a-zebrafish-research-project-into-a-molecular-biology-course-to-support-critical-thinking-and-course-content-goals
#19
Lisa K Felzien
Engaging undergraduates in research is essential for teaching them to think like scientists, and it has become a desired component of classroom and laboratory instruction. Research projects that span an entire semester expose students to a variety of concepts and techniques and allow students to use experiments to learn scientific principles, understand why specific techniques are applicable, critically analyze varied data, and examine how experimentation leads to acquiring knowledge. To provide an experience with these features, a semester long research project was integrated into a combined lecture and laboratory course, Molecular Biology...
November 12, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27229373/a-ten-week-biochemistry-lab-project-studying-wild-type-and-mutant-bacterial-alkaline-phosphatase
#20
D Scott Witherow
This work describes a 10-week laboratory project studying wild-type and mutant bacterial alkaline phosphatase, in which students purify, quantitate, and perform kinetic assays on wild-type and selected mutants of the enzyme. Students also perform plasmid DNA purification, digestion, and gel analysis. In addition to simply learning important techniques, students acquire novel biochemical data in their kinetic analysis of mutant enzymes. The experiments are designed to build on students' work from week to week in a way that requires them to apply quantitative analysis and reasoning skills, reinforcing traditional textbook biochemical concepts...
November 12, 2016: Biochemistry and Molecular Biology Education
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