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Biochemistry and Molecular Biology Education

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https://www.readbyqxmd.com/read/28314074/better-understanding-of-homologous-recombination-through-a-12-week-laboratory-course-for-undergraduates-majoring-in-biotechnology
#1
Ming Li, Xiaodong Shen, Yan Zhao, Xiaomei Hu, Fuquan Hu, Xiancai Rao
Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis of homologous recombination. In this study, we developed and implemented a 12-week laboratory course for biotechnology undergraduates in which gene targeting in Streptococcus suis was used to facilitate their understanding of the basic concept and process of homologous recombination...
March 17, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28294503/exploring-protein-structure-and-dynamics-through-a-project-oriented-biochemistry-laboratory-module
#2
James M Lipchock, Patrick S Ginther, Bonnie B Douglas, Kelly E Bird, J Patrick Loria
Here, we present a 10-week project-oriented laboratory module designed to provide a course-based undergraduate research experience in biochemistry that emphasizes the importance of biomolecular structure and dynamics in enzyme function. This module explores the impact of mutagenesis on an important active site loop for a biomedically-relevant human enzyme, protein tyrosine phosphatase 1B (PTP1B). Over the course of the semester students guide their own mutant of PTP1B from conception to characterization in a cost-effective manner and gain exposure to fundamental techniques in biochemistry, including site-directed DNA mutagenesis, bacterial recombinant protein expression, affinity column purification, protein quantitation, SDS-PAGE, and enzyme kinetics...
March 13, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28251766/new-horizons-in-biochemistry-molecular-biology-education-an-iubmb-sponsored-conference-5-8-september-2017-weizmann-institute-of-science-israel
#3
EDITORIAL
Gül Güner Akdogan, Janet Macaulay, Phillip Ortiz, Anat Yarden
No abstract text is available yet for this article.
March 2, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28251763/a-13-week-research-based-biochemistry-laboratory-curriculum
#4
Scott T Lefurgy, Emily C Mundorff
Here, we present a 13-week research-based biochemistry laboratory curriculum designed to provide the students with the experience of engaging in original research while introducing foundational biochemistry laboratory techniques. The laboratory experience has been developed around the directed evolution of an enzyme chosen by the instructor, with mutations designed by the students. Ideal enzymes for this curriculum are able to be structurally modeled, solubly expressed, and monitored for activity by UV/Vis spectroscopy, and an example curriculum for haloalkane dehalogenase is given...
March 2, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28230335/undergraduate-medical-academic-performance-is-improved-by-scientific-training
#5
Lili Zhang, Wei Zhang, Chong Wu, Zhongming Liu, Yunfei Cai, Xingguo Cao, Yushan He, Guoxiang Liu, Hongming Miao
The effect of scientific training on course learning in undergraduates is still controversial. In this study, we investigated the academic performance of undergraduate students with and without scientific training. The results show that scientific training improves students' test scores in general medical courses, such as biochemistry and molecular biology, cell biology, physiology, and even English. We classified scientific training into four levels. We found that literature reading could significantly improve students' test scores in general courses...
February 23, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28230314/approaches-to-enhance-the-teaching-quality-of-experimental-biochemistry-for-mbbs-students-in-tsmu-china
#6
Lijuan Yu, Shuying Yi, Jing Zhai, Zhaojin Wang
With the internationalization of medical education in China, the importance of international students' education in medical schools is also increasing. Except foreign students majoring in Chinese language, English Bachelor of Medicine, Bachelor of Surgery (MBSS) students are the largest group of international students. Based on problems in the teaching process for experimental biochemistry, we designed teaching models adapted to the background of international students and strengthened teachers' teaching ability at Taishan Medical University...
February 23, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28220642/does-relevancy-matter
#7
LETTER
Daniel J Klionsky
No abstract text is available yet for this article.
February 20, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28205321/an-investigative-graduate-laboratory-course-for-teaching-modern-dna-techniques
#8
Alexandre de Lencastre, A Thomas Torello, Lani C Keller
This graduate-level DNA methods laboratory course is designed to model a discovery-based research project and engages students in both traditional DNA analysis methods and modern recombinant DNA cloning techniques. In the first part of the course, students clone the Drosophila ortholog of a human disease gene of their choosing using Gateway(®) cloning. In the second part of the course, students examine the expression of their gene of interest in human cell lines by reverse transcription PCR and learn how to analyze data from quantitative reverse transcription PCR (qRT-PCR) experiments...
February 16, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28145107/a-comprehensive-experiment-for-molecular-biology-determination-of-single-nucleotide-polymorphism-in-human-rev3-gene-using-pcr-rflp
#9
Xu Zhang, Meng Shao, Lu Gao, Yuanyuan Zhao, Zixuan Sun, Liping Zhou, Yongmin Yan, Qixiang Shao, Wenrong Xu, Hui Qian
Laboratory exercise is helpful for medical students to understand the basic principles of molecular biology and to learn about the practical applications of molecular biology. We have designed a lab course on molecular biology about the determination of single nucleotide polymorphism (SNP) in human REV3 gene, the product of which is a subunit of DNA polymerase ζ and SNPs in this gene are associated with altered susceptibility to cancer. This newly designed experiment is composed of three parts, including genomic DNA extraction, gene amplification by PCR, and genotyping by RFLP...
February 1, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28145077/using-molecular-visualization-to-explore-protein-structure-and-function-and-enhance-student-facility-with-computational-tools
#10
Cassidy R Terrell, Laura L Listenberger
Recognizing that undergraduate students can benefit from analysis of 3D protein structure and function, we have developed a multiweek, inquiry-based molecular visualization project for Biochemistry I students. This project uses a virtual model of cyclooxygenase-1 (COX-1) to guide students through multiple levels of protein structure analysis. The first assignment explores primary structure by generating and examining a protein sequence alignment. Subsequent assignments introduce 3D visualization software to explore secondary, tertiary, and quaternary structure...
February 1, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28145074/assessment-of-knowledge-of-participants-on-basic-molecular-biology-techniques-after-5-day-intensive-molecular-biology-training-workshops-in-nigeria
#11
J I Yisau, A O Adagbada, T Bamidele, M Fowora, B I C Brai, O Adebesin, M Bamidele, T Fesobi, F O Nwaokorie, A Ajayi, S I Smith
The deployment of molecular biology techniques for diagnosis and research in Nigeria is faced with a number of challenges, including the cost of equipment and reagents coupled with the dearth of personnel skilled in the procedures and handling of equipment. Short molecular biology training workshops were conducted at the Nigerian Institute of Medical Research (NIMR), to improve the knowledge and skills of laboratory personnel and academics in health, research, and educational facilities. Five-day molecular biology workshops were conducted annually between 2011 and 2014, with participants drawn from health, research facilities, and the academia...
February 1, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28059472/promoting-active-learning-of-graduate-student-by-deep-reading-in-biochemistry-and-microbiology-pharmacy-curriculum
#12
Ren Peng
To promote graduate students' active learning, deep reading of high quality papers was done by graduate students enrolled in biochemistry and microbiology pharmacy curriculum offered by college of life science, Jiangxi Normal University from 2013 to 2015. The number of graduate students, who participated in the course in 2013, 2014, and 2015 were eleven, thirteen and fifteen, respectively. Through deep reading of papers, presentation, and group discussion in the lecture, these graduate students have improved their academic performances effectively, such as literature search, PPT document production, presentation management, specialty document reading, academic inquiry, and analytical and comprehensive ability...
January 6, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28032413/variation-in-external-representations-as-part-of-the-classroom-lecture-an-investigation-of-virtual-cell-animations-in-introductory-photosynthesis-instruction
#13
Eric E Goff, Katie M Reindl, Christina Johnson, Phillip McClean, Erika G Offerdahl, Noah L Schroeder, Alan R White
The use of external representations (ERs) to introduce concepts in undergraduate biology has become increasingly common. Two of the most prevalent are static images and dynamic animations. While previous studies comparing static images and dynamic animations have resulted in somewhat conflicting findings in regards to learning outcomes, the benefits of each have been shown individually. Using ERs developed by the Virtual Cell Animation project, we aim to further investigate student learning using different ERs as part of an introductory biology lecture...
December 28, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28032403/a-unique-large-scale-undergraduate-research-experience-in-molecular-systems-biology-for-non-mathematics-majors
#14
Ulrike Kappler, Susan L Rowland, Rhianna K Pedwell
Systems biology is frequently taught with an emphasis on mathematical modeling approaches. This focus effectively excludes most biology, biochemistry, and molecular biology students, who are not mathematics majors. The mathematical focus can also present a misleading picture of systems biology, which is a multi-disciplinary pursuit requiring collaboration between biochemists, bioinformaticians, and mathematicians. This article describes an authentic large-scale undergraduate research experience (ALURE) in systems biology that incorporates proteomics, bacterial genomics, and bioinformatics in the one exercise...
December 28, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28101912/meetings-calendar
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27486685/an-expanded-framework-for-biomolecular-visualization-in-the-classroom-learning-goals-and-competencies
#16
Daniel R Dries, Diane M Dean, Laura L Listenberger, Walter R P Novak, Margaret A Franzen, Paul A Craig
A thorough understanding of the molecular biosciences requires the ability to visualize and manipulate molecules in order to interpret results or to generate hypotheses. While many instructors in biochemistry and molecular biology use visual representations, few indicate that they explicitly teach visual literacy. One reason is the need for a list of core content and competencies to guide a more deliberate instruction in visual literacy. We offer here the second stage in the development of one such resource for biomolecular three-dimensional visual literacy...
January 2, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27357493/embedding-responsible-conduct-in-learning-and-research-into-an-australian-undergraduate-curriculum
#17
Lynette B Fernandes
Responsible conduct in learning and research (RCLR) was progressively introduced into the pharmacology curriculum for undergraduate science students at The University of Western Australia. In the second year of this undergraduate curriculum, a lecture introduces students to issues such as the use of animals in teaching and responsible conduct of research. Third year student groups deliver presentations on topics including scientific integrity and the use of human subjects in research. Academic and research staff attending these presentations provide feedback and participate in discussions...
January 2, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27357379/cures-in-biochemistry-where-we-are-and-where-we-should-go
#18
EDITORIAL
Jessica K Bell, Todd T Eckdahl, David A Hecht, Patrick J Killion, Joachim Latzer, Tamara L Mans, Joseph J Provost, John F Rakus, Erica A Siebrasse, J Ellis Bell
Integration of research experience into classroom is an important and vital experience for all undergraduates. These course-based undergraduate research experiences (CUREs) have grown from independent instructor lead projects to large consortium driven experiences. The impact and importance of CUREs on students at all levels in biochemistry was the focus of a National Science Foundation funded think tank. The state of biochemistry CUREs and suggestions for moving biochemistry forward as well as a practical guide (supplementary material) are reported here...
January 2, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27353527/arsenic-based-life-an-active-learning-assignment-for-teaching-scientific-discourse
#19
R Jeremy Johnson
Among recent high profile scientific debates was the proposal that life could exist with arsenic in place of phosphorous in its nucleic acids and other biomolecules. Soon after its initial publication, scientists across diverse disciplines began to question this extraordinary claim. Using the original article, its claims, its scientific support, and the ensuing counterarguments, a two-day, active learning classroom exercise was developed focusing on the presentation, evaluation, and discussion of scientific argumentation and discourse...
January 2, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27322926/design-and-evaluation-of-a-digital-module-with-guided-peer-feedback-for-student-learning-biotechnology-and-molecular-life-sciences-attitudinal-change-and-satisfaction
#20
Omid Noroozi, Martin Mulder
This study aims to investigate the impacts of a digital learning module with guided peer feedback on students' domain-specific knowledge gain and their attitudinal change in the field of biotechnology and molecular life sciences. The extent to which the use of this module is appreciated by students is studied as well. A pre-test, post-test design was used with 203 students who were randomly assigned to groups of three. They were asked to work on the digital module with the aim of exploring various perspectives, and the "pros and cons" on the topic of "Genetically Modified Organisms (GMOs)...
January 2, 2017: Biochemistry and Molecular Biology Education
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