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Biochemistry and Molecular Biology Education

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https://www.readbyqxmd.com/read/28902453/implementing-a-web-based-introductory-bioinformatics-course-for-non-bioinformaticians-that-incorporates-practical-exercises
#1
Antony T Vincent, Yves Bourbonnais, Jean-Simon Brouard, Hélène Deveau, Arnaud Droit, Stéphane M Gagné, Michel Guertin, Claude Lemieux, Louis Rathier, Steve J Charette, Patrick Lagüe
A recent scientific discipline, bioinformatics, defined as using informatics for the study of biological problems, is now a requirement for the study of biological sciences. Bioinformatics has become such a powerful and popular discipline that several academic institutions have created programs in this field, allowing students to become specialized. However, biology students who are not involved in a bioinformatics program also need a solid toolbox of bioinformatics software and skills. Therefore, we have developed a completely online bioinformatics course for non-bioinformaticians, entitled "BIF-1901 Introduction à la bio-informatique et à ses outils (Introduction to bioinformatics and bioinformatics tools)," given by the Department of Biochemistry, Microbiology, and Bioinformatics of Université Laval (Quebec City, Canada)...
September 13, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28902439/promoting-mastery-of-complex-biological-mechanisms
#2
William S Bradshaw, Kathryn J Groneman, Jennifer Nelson, John D Bell
This article describes efforts aimed at improving comprehension and retention of complex molecular mechanisms commonly studied in undergraduate biology and biochemistry courses. The focus is on the design of appropriate assessments, an active classroom emphasizing formative practice, and more effective out-of-class study habits. Assessments that require students to articulate their understanding through writing are the most effective. Frequent formative practice improves performance on problems that require intellectual transfer, the ability to apply conceptual principles in novel settings...
September 13, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28858410/intentionally-flawed-manuscripts-as-means-for-teaching-students-to-critically-evaluate-scientific-papers
#3
Jaroslav Ferenc, Filip Červenák, Erik Birčák, Katarína Juríková, Ivana Goffová, Peter Gorilák, Barbora Huraiová, Jana Plavá, Loriana Demecsová, Nikola Ďuríková, Veronika Galisová, Matej Gazdarica, Marek Puškár, Tibor Nagy, Soňa Nagyová, Lucia Mentelová, Miroslava Slaninová, Andrea Ševčovicová, Ľubomír Tomáška
As future scientists, university students need to learn how to avoid making errors in their own manuscripts, as well as how to identify flaws in papers published by their peers. Here we describe a novel approach on how to promote students' ability to critically evaluate scientific articles. The exercise is based on instructing teams of students to write intentionally flawed manuscripts describing the results of simple experiments. The teams are supervised by instructors advising the students during manuscript writing, choosing the 'appropriate' errors, monitoring the identification of errors made by the other team and evaluating the strength of their arguments in support of the identified errors...
August 31, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28858403/songs-about-cancer-gene-expression-and-the-biochemistry-of-photosynthesis
#4
Richard H Heineman
These three biology songs can be used for educational purposes to teach about biochemical concepts. They touch on three different topics: (1) cancer progression and germ cells, (2) gene expression, promoters, and repressors, and (3) electronegativity and the biochemical basis of photosynthesis. © 2017 by The International Union of Biochemistry and Molecular Biology, 2017.
August 31, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28843018/browning-in-apples-exploring-the-biochemical-basis-of-an-easily-observable-phenotype
#5
Charles E Deutch
Many fruits and vegetables undergo browning when they are cut and the tissue is exposed to the air. This is due to the activity of the enzyme polyphenol oxidase (PPO, EC 1.14.18.1) with endogenous substrates. In this laboratory experiment, students prepare slices of different varieties of apples and assess the rate of browning. They make a simple extract of the apple tissue and measure the activity of PPO using 3,4-dihydroxy-l-phenylalanine (l-DOPA) as substrate. They determine the protein concentration of the extract with the Bradford Coomassie Blue reagent and calculate the specific activity of PPO...
August 26, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28782152/virtual-protein-purification-a-simple-exercise-to-introduce-ph-as-a-parameter-that-effects-ion-exchange-chromatography
#6
Daniel D Clark, Daniel J Edwards
This article describes a simple exercise using a free, easy-to-use, established online program. The exercise helps to reinforce protein purification concepts and introduces undergraduates to pH as a parameter that affects anion-exchange chromatography. The exercise was tested with biochemistry majors at California State University-Chico. Given the versatility of the program, this work is also a model for instructors that wish to develop their own exercise to help teach other protein purification techniques...
August 6, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28758374/circular-dichroism-spectroscopy-enhancing-a-traditional-undergraduate-biochemistry-laboratory-experience
#7
Russell L Lewis, Erin L Seal, Aimee R Lorts, Amanda L Stewart
The undergraduate biochemistry laboratory curriculum is designed to provide students with experience in protein isolation and purification protocols as well as various data analysis techniques, which enhance the biochemistry lecture course and give students a broad range of tools upon which to build in graduate level laboratories or once they begin their careers. One of the most common biochemistry protein purification experiments is the isolation and characterization of cytochrome c. Students across the country purify cytochrome c, lysozyme, or some other well-known protein to learn these common purification techniques...
July 30, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28758334/-31-p-nmr-of-the-pyruvate-kinase-reaction-an-undergraduate-experiment-in-enzyme-kinetics
#8
R Marshall Werner, Austin Johnson
Understanding how to perform an enzyme assay is a critical learning skill in the undergraduate biochemistry curriculum. Students in biochemistry typically have been exposed to the use of NMR spectroscopy as a tool to determine chemical structure, but rarely are they exposed to the utility of NMR to evaluate enzyme kinetics. Furthermore, coverage of NMR experiments utilizing "alternative nuclei", such as (15) N, (19) F, and (31) P may be neglected. Herein we report a simple (31) P NMR tube experiment that allows students to examine the enzyme kinetics and equilibrium constant of the reaction catalyzed by pyruvate kinase...
July 30, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28758332/a-biosafety-level-2-virology-lab-for-biotechnology-undergraduates
#9
Sigal Matza-Porges, Dafna Nathan
Medical, industrial, and basic research relies heavily on the use of viruses and vectors. Therefore, it is important that bioscience undergraduates learn the practicalities of handling viruses. Teaching practical virology in a student laboratory setup presents safety challenges, however. The aim of this article is to describe the design and implementation of a virology laboratory, with emphasis on student safety, for biotechnology undergraduates. Cell culture techniques, animal virus infection, quantification, and identification are taught at a biosafety level 2 for a diverse group of undergraduates ranging from 20 to 50 students per group...
July 30, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28681994/creating-3d-physical-models-to-probe-student-understanding-of-macromolecular-structure
#10
A Kat Cooper, M T Oliver-Hoyo
The high degree of complexity of macromolecular structure is extremely difficult for students to process. Students struggle to translate the simplified two-dimensional representations commonly used in biochemistry instruction to three-dimensional aspects crucial in understanding structure-property relationships. We designed four different physical models to address student understanding of electrostatics and noncovalent interactions and their relationship to macromolecular structure. In this study, we have tested these models in classroom settings to determine if these models are effective in engaging students at an appropriate level of difficulty and focusing student attention on the principles of electrostatic attractions...
July 6, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28670831/varying-iron-release-from-transferrin-and-lactoferrin-proteins-a-laboratory-experiment
#11
Fernando Carmona, Ana González, Manu Sánchez, Natividad Gálvez, Rafael Cuesta, Mercè Capdevila, Jose M Dominguez-Vera
Iron metabolism is an important subject of study for undergraduate students of chemistry and biochemistry. Relevant laboratory exercises are scarce in the literature but would be very helpful in assisting students grasp key concepts. The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: serum transferrin (Tf) and lactoferrin (Lf). Despite having very similar structures and iron-binding sites, Tf releases practically all its iron at pH 5.5 while Lf requires a significantly lower pH of 3...
July 3, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28665030/idea-worthy-to-explore-connecting-global-and-local-in-teaching-about-diseases
#12
EDITORIAL
Susan A White
No abstract text is available yet for this article.
June 30, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28929604/meetings-calendar
#13
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696056/meetings-calendar
#14
(no author information available yet)
No abstract text is available yet for this article.
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696055/practices-and-exploration-on-competition-of-molecular-biological-detection-technology-among-students-in-food-quality-and-safety-major
#15
Yaning Chang, Yuke Peng, Pengfei Li, Yingping Zhuang
With the increasing importance in the application of the molecular biological detection technology in the field of food safety, strengthening education in molecular biology experimental techniques is more necessary for the culture of the students in food quality and safety major. However, molecular biology experiments are not always in curricula of Food quality and safety Majors. This paper introduced a project "competition of molecular biological detection technology for food safety among undergraduate sophomore students in food quality and safety major", students participating in this project needed to learn the fundamental molecular biology experimental techniques such as the principles of molecular biology experiments and genome extraction, PCR and agarose gel electrophoresis analysis, and then design the experiments in groups to identify the meat species in pork and beef products using molecular biological methods...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696054/undergraduate-research-as-curriculum
#16
EDITORIAL
Erin L Dolan
To date, national interests, policies, and calls for transformation of undergraduate education have been the main drivers of research integration into the undergraduate curriculum, briefly described here. The New Horizons in Biochemistry and Molecular Biology Education conference at the Weizmann Institute of Science (Israel) this fall presents an exciting opportunity to discuss integration of undergraduate research into the curriculum and other cutting-edge topics in biochemistry and molecular biology education from a cross-national perspective...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28696053/learning-effectiveness-and-satisfaction-of-international-medical-students-introducing-a-hybrid-pbl-curriculum-in-biochemistry
#17
Qiu Yan, Li Ma, Lina Zhu, Wenli Zhang
A biochemistry course is a fundamental but important subject in medical education in China. In recent years, the number of international medical students has increased. Curriculum reform in biochemistry teaching is needed because of the knowledge limitations of students, a close linkage of biochemical content with clinics, the shortcomings of lecture-centered teaching, and the requirements for early clinical practice training and competence. In this study, we analyzed a novel curriculum reform, "Hybrid-PBL," which combined problem-based learning (PBL) with biochemistry lectures and was implemented for biochemical teaching at Dalian Medical University (DMU) in China...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28314074/better-understanding-of-homologous-recombination-through-a-12-week-laboratory-course-for-undergraduates-majoring-in-biotechnology
#18
Ming Li, Xiaodong Shen, Yan Zhao, Xiaomei Hu, Fuquan Hu, Xiancai Rao
Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis of homologous recombination. In this study, we developed and implemented a 12-week laboratory course for biotechnology undergraduates in which gene targeting in Streptococcus suis was used to facilitate their understanding of the basic concept and process of homologous recombination...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28230314/approaches-to-enhance-the-teaching-quality-of-experimental-biochemistry-for-mbbs-students-in-tsmu-china
#19
Lijuan Yu, Shuying Yi, Jing Zhai, Zhaojin Wang
With the internationalization of medical education in China, the importance of international students' education in medical schools is also increasing. Except foreign students majoring in Chinese language, English Bachelor of Medicine, Bachelor of Surgery (MBSS) students are the largest group of international students. Based on problems in the teaching process for experimental biochemistry, we designed teaching models adapted to the background of international students and strengthened teachers' teaching ability at Taishan Medical University...
July 8, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28205321/an-investigative-graduate-laboratory-course-for-teaching-modern-dna-techniques
#20
Alexandre de Lencastre, A Thomas Torello, Lani C Keller
This graduate-level DNA methods laboratory course is designed to model a discovery-based research project and engages students in both traditional DNA analysis methods and modern recombinant DNA cloning techniques. In the first part of the course, students clone the Drosophila ortholog of a human disease gene of their choosing using Gateway(®) cloning. In the second part of the course, students examine the expression of their gene of interest in human cell lines by reverse transcription PCR and learn how to analyze data from quantitative reverse transcription PCR (qRT-PCR) experiments...
July 8, 2017: Biochemistry and Molecular Biology Education
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