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Biochemistry and Molecular Biology Education

Zhongneng Xu, Yayun Yang, Beibei Huang
The Needleman-Wunsch algorithm has become one of the core algorithms in bioinformatics; however, this programming requires more suitable explanations for students with different major backgrounds. In supposing sample sequences and using a simple store system, the connection between the exhaustive search method and the Needleman-Wunsch algorithm was analyzed to more thoroughly explain this algorithm. The present study could benefit the teaching and learning of the Needleman-Wunsch algorithm. © 2016 by The International Union of Biochemistry and Molecular Biology, 2016...
October 14, 2016: Biochemistry and Molecular Biology Education
R Jeremy Johnson, Jacob Applegarth, Steven Bennett, Sydney Caskey, Connor Coatney, Kurt Corsbie, Allison Cotter, Daniel Cotter, Alexis Coulis, Heather Hansen, Whitney Hart, Cutter Koehler, Andrew Koelper, Stephanie Kuhlman, Chandler Mitchell, Blake Moskal, Olivia Murfield, Allie Paton, Daniel Schemenauer, Brittany Stankavich, Clayton Taylor, Brent Waibel, L Dean Williams
No abstract text is available yet for this article.
September 28, 2016: Biochemistry and Molecular Biology Education
Kevin T Militello, Justine C Lazatin
Clustered regularly interspaced short palindromic repeats (CRISPRs) represent a novel type of adaptive immune system found in eubacteria and archaebacteria. CRISPRs have recently generated a lot of attention due to their unique ability to catalog foreign nucleic acids, their ability to destroy foreign nucleic acids in a mechanism that shares some similarity to RNA interference, and the ability to utilize reconstituted CRISPR systems for genome editing in numerous organisms. In order to introduce CRISPR biology into an undergraduate upper-level laboratory, a five-week set of exercises was designed to allow students to examine the CRISPR status of uncharacterized Escherichia coli strains and to allow the discovery of new repeats and spacers...
September 28, 2016: Biochemistry and Molecular Biology Education
Marcus Antonius Ynalvez, Ruby A Ynalvez, Enrique Ramírez
We explored the social shaping of science at the micro-level reality of face-to-face interaction in one of the traditional places for scientific activities-the scientific lab. We specifically examined how doctoral students' perception of their: (i) interaction with doctoral mentors (MMI) and (ii) lab social environment (LSE) influenced productivity. Construed as the production of peer-reviewed articles, we measured productivity using total number of articles (TOTAL), number of articles with impact factor greater than or equal to 4...
September 26, 2016: Biochemistry and Molecular Biology Education
Eric Lacazette
Chromatin immunoprecipitation followed by qPCR analysis (ChIP-qPCR) is a widely used technique to study gene expression. A large number of students in molecular biology and more generally in life sciences will be confronted with the use of this technique, which is quite difficult to set up and can lead to misinterpretation if not carefully managed. This article describes a four-session laboratory practical designed for Masters students to introduce this technique. During the practical, students work in pairs...
September 26, 2016: Biochemistry and Molecular Biology Education
Belén M De Luca, Clara B Nudel, Rodrigo H Gonzalez, Alejandro D Nusblat
Biocatalysis is a fundamental concept in biotechnology. The topic integrates knowledge of several disciplines; therefore, it was included in the course "design and optimization of biological systems" which is offered in the biochemistry curricula. We selected the ciliate tetrahymena as an example of a eukaryotic system with potential for the biotransformation of sterol metabolites of industrial interest; in particular, we focused on the conversion of cholesterol to provitamin D3. The students work with wild type and recombinant strains and learn how sterol pathways could be modified to obtain diverse sterol moieties...
September 26, 2016: Biochemistry and Molecular Biology Education
Austin U Gehret
A kinesthetic classroom activity was designed to help students understand enzyme activity and catalysis of reaction rate. Students served the role of enzymes by manipulating Pop-It Beads as the catalytic event. This activity illuminates the relationship between reaction rate and reaction progress by allowing students to experience first-hand the effect of substrate depletion on catalyzed reaction rate. Preliminary findings based on survey results and exam performance suggest the activity could prove beneficial to students in the targeted learning outcomes...
September 10, 2016: Biochemistry and Molecular Biology Education
Ebru Öztürk-Akar
This study questions the presumed relation between formal schooling and scientific literacy about biotechnologies. Comparing science and nonscience majors' knowledge of and attitudes toward biotechnological applications, conclusions are drawn if their formal learnings improve pupils' understandings of and attitudes toward biotechnology applications. Sample of the study consists of 403 undergraduate and graduate students, 198 nonscience, and 205 science majors. The Biotechnology Knowledge Questionnaire and the Biotechnology Attitude Questionnaire were administered...
September 10, 2016: Biochemistry and Molecular Biology Education
Ann T S Taylor, Eric L Olofson, Walter R P Novak
To foster the connection between biochemistry and the supporting prerequisite concepts, a collection of activities that explicitly link general and organic chemistry concepts to biochemistry ideas was written and either assigned as pre-class work or as recitation activities. We assessed student learning gains after using these activities alone, or in combination with regularly-integrated clicker and discussion questions. Learning gains were determined from student performance on pre- and post-tests covering key prerequisite concepts, biochemistry course exams, and student self-evaluation...
August 18, 2016: Biochemistry and Molecular Biology Education
Daniel R Dries, Diane M Dean, Laura L Listenberger, Walter R P Novak, Margaret A Franzen, Paul A Craig
A thorough understanding of the molecular biosciences requires the ability to visualize and manipulate molecules in order to interpret results or to generate hypotheses. While many instructors in biochemistry and molecular biology use visual representations, few indicate that they explicitly teach visual literacy. One reason is the need for a list of core content and competencies to guide a more deliberate instruction in visual literacy. We offer here the second stage in the development of one such resource for biomolecular three-dimensional visual literacy...
August 3, 2016: Biochemistry and Molecular Biology Education
(no author information available yet)
No abstract text is available yet for this article.
September 10, 2016: Biochemistry and Molecular Biology Education
Y J Borrell, A M Muñoz-Colmenero, E Dopico, L Miralles, E Garcia-Vazquez
A Citizen Science approach was implemented in the laboratory practices of Genetics at the University of Oviedo, related with the engaging topic of Food Control. Real samples of food products consumed by students at home (students as samplers) were employed as teaching material in three different courses of Genetics during the academic year 2014-2015: Experimental Methods in Food Production (MBTA) (Master level), and Applied Molecular Biology (BMA) and Conservation Genetics and Breeding (COMGE) (Bachelor/Degree level)...
September 10, 2016: Biochemistry and Molecular Biology Education
Rachel E Rigsby, Alison B Parker
Visualization of chemical concepts can be challenging for many students. This is arguably a critical skill for beginning students of biochemistry to develop, since new information is often presented visually in the form of textbook figures. It is recommended that visual literacy be explicitly taught in the classroom rather than assuming that students will develop this skill on their own.  The activity described here is designed to assist students in their development of understanding of basic representations of protein three-dimensional structure as well as various types of ligands (small molecules, ions) through the use of the iPad application PyMOL...
September 10, 2016: Biochemistry and Molecular Biology Education
Vilja Siitonen, Kaj Räty, Mikko Metsä-Ketelä
The "Streptomyces genetics and secondary metabolism" laboratory course gives an introduction to the versatile soil dwelling Gram-positive bacteria Streptomyces and their secondary metabolism. The course combines genetic modification of Streptomyces; growing of the strain and protoplast preparation, plasmid isolation by alkaline lysis and phenol precipitation, digestions, and ligations prior to protoplast transformation, as well as investigating the secondary metabolites produced by the strains. Thus, the course is a combination of microbiology, molecular biology, and chemistry...
September 10, 2016: Biochemistry and Molecular Biology Education
Shao-Yen Chen, Yih-Ru Chu, Chen-Yung Lin, Tzen-Yuh Chiang
Modern biotechnology is one of the most important scientific and technological revolutions in the 21st century, with an increasing and measurable impact on society. Development of biotechnology curriculum has become important to high school bioscience classrooms. This study has monitored high school students in Taiwan on their knowledge of and attitudes towards biotechnology for nearly two decades. Not surprisingly, knowledge of biotechnology of current students has increased significantly (p < 0.001) and most students have learned some definitions and examples of biotechnology...
September 10, 2016: Biochemistry and Molecular Biology Education
Anne M Brown, Stephanie N Lewis, David R Bevan
Participating in undergraduate research can be a pivotal experience for students in life science disciplines. Development of critical thinking skills, in addition to conveying scientific ideas in oral and written formats, is essential to ensuring that students develop a greater understanding of basic scientific knowledge and the research process. Modernizing the current life sciences research environment to accommodate the growing demand by students for experiential learning is needed. By developing and implementing a structured, theory-based approach to undergraduate research in the life sciences, specifically biochemistry, it has been successfully shown that more students can be provided with a high-quality, high-impact research experience...
September 10, 2016: Biochemistry and Molecular Biology Education
Petra Bauer
The presented research hypothesis-driven laboratory exercise teaches advanced undergraduate students state of the art methods and thinking in an integrated molecular physiology context. Students understand the theoretical background of iron acquisition in the model plant Arabidopsis thaliana. They design a flowchart summarizing the key steps of the experimental approach. Students are made familiar with current techniques such as qPCR. Following their experimental outline, students grow Arabidopsis seedlings up to the age of six days under sufficient and deficient iron supply...
September 10, 2016: Biochemistry and Molecular Biology Education
Cristina Almeida-Aguiar, Ana Amélia Carvalho
Podcasts are digital files very popular in several and very distinct areas. In higher education, they have been explored in a multitude of ways mainly to support teaching and learning processes. The study here described focuses the integration of podcasts in Heredity and Evolution, a course from the Biology and Geology Degree Program at University of Minho, Portugal. It aimed to introduce podcasts in the teaching/learning context, to empirically study different dimensions of podcasting, and to evaluate students' acceptance and receptiveness to the pedagogical use of this technology...
September 10, 2016: Biochemistry and Molecular Biology Education
(no author information available yet)
No abstract text is available yet for this article.
July 8, 2016: Biochemistry and Molecular Biology Education
Jessica J Vanderlelie, Heather G Alexander
Assessment plays a critical role in learning and teaching and its power to enhance engagement and student outcomes is still underestimated in tertiary education. The current project considers the impact of a staged redesign of an assessment strategy that emphasized relevance of learning, formative assessment, student engagement, and feedback on student performance, failure rates and overall engagement in the course. Significant improvements in final grades (p < 0.0001) and written performance (p < 0...
July 8, 2016: Biochemistry and Molecular Biology Education
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