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BMC Urology

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https://www.readbyqxmd.com/read/29769123/obesity-impairs-male-fertility-through-long-term-effects-on-spermatogenesis
#1
Yan-Fei Jia, Qian Feng, Zheng-Yan Ge, Ying Guo, Fang Zhou, Kai-Shu Zhang, Xiao-Wei Wang, Wen-Hong Lu, Xiao-Wei Liang, Yi-Qun Gu
OBJECTIVE: This study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats. METHODS: A total of 45 male rats were randomly divided into control (n = 15, normal diet) and obesity groups (n = 30, high-fat diet) and were fed for 16 weeks. Body weight and organ indexes were determined after sacrifice. Indicators of reproductive function, including sperm count, sperm motility, apoptosis of spermatogenic cells, and oxidative stress levels, were measured...
May 16, 2018: BMC Urology
https://www.readbyqxmd.com/read/29764415/perioperative-outcomes-of-zero-ischemia-radiofrequency-ablation-assisted-tumor-enucleation-for-renal-cell-carcinoma-results-of-182-patients
#2
Chengwei Zhang, Xiaozhi Zhao, Suhan Guo, Changwei Ji, Wei Wang, Hongqian Guo
BACKGROUND: To evaluate the perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation. METHODS: Patients undergoing zero ischemia radiofrequency ablation-assisted tumor enucleation were retrospectively identified from July 2008 to March 2013. The tumor was enucleated after RFA treatment. R.E.N.A.L., PADUA and centrality index (C-index) score systems were used to assess each tumor case. We analyzed the correlation of perioperative outcomes with these scores...
May 15, 2018: BMC Urology
https://www.readbyqxmd.com/read/29751751/primary-synovial-sarcoma-of-the-kidney-a-case-report-of-complete-pathological-response-at-a-lebanese-tertiary-care-center
#3
Alissar El Chediak, Deborah Mukherji, Sally Temraz, Samer Nassif, Sara Sinno, Rami Mahfouz, Ali Shamseddine
BACKGROUND: Primary synovial sarcoma of the kidney is a rare type of soft tissue sarcoma. Its presenting features can resemble those of other renal tumors; rendering its early diagnosis, a dilemma. Several cases of renal synovial sarcoma have been reported in the literature with varying treatment options and outcomes. This article describes a rare case of primary renal synovial sarcoma and reviews all cases in the literature. CASE PRESENTATION: A 26-year-old male presented with flank pain and hematuria...
May 11, 2018: BMC Urology
https://www.readbyqxmd.com/read/29747596/hand-assisted-living-donor-nephrectomy-a-retrospective-comparison-of-two-techniques
#4
Jeannette D Widmer, Andrea Schlegel, Philipp Kron, Marc Schiesser, Jens G Brockmann, Markus K Muller
BACKGROUND: Living-donor nephrectomy (LDN) is challenging, as surgery is performed on healthy individuals. Minimally invasive techniques for LDN have become standard in most centers. Nevertheless, numerous techniques have been described with no consensus on which is the superior approach. Both hand-assisted retroperitoneoscopic (HARS) and hand-assisted laparoscopic (HALS) LDNs are performed at Zurich University Hospital. The aim of this study was to compare these two surgical techniques in terms of donor outcome and graft function...
May 10, 2018: BMC Urology
https://www.readbyqxmd.com/read/29743049/cost-implications-of-psa-screening-differ-by-age
#5
Karthik Rao, Stella Liang, Michael Cardamone, Corinne E Joshu, Kyle Marmen, Nrupen Bhavsar, William G Nelson, H Ballentine Carter, Michael C Albert, Elizabeth A Platz, Craig E Pollack
BACKGROUND: Multiple guidelines seek to alter rates of prostate-specific antigen (PSA)-based prostate cancer screening. The costs borne by payers associated with PSA-based screening for men of different age groups-including the costs of screening and subsequent diagnosis, treatment, and adverse events-remain uncertain. We sought to develop a model of PSA costs that could be used by payers and health care systems to inform cost considerations under a range of different scenarios. METHODS: We determined the prevalence of PSA screening among men aged 50 and higher using 2013-2014 data from a large, multispecialty group, obtained reimbursed costs associated with screening, diagnosis, and treatment from a commercial health plan, and identified transition probabilities for biopsy, diagnosis, treatment, and complications from the literature to generate a cost model...
May 9, 2018: BMC Urology
https://www.readbyqxmd.com/read/29739455/longitudinal-recovery-patterns-of-penile-length-and-the-underexplored-benefit-of-long-term-phosphodiesterase-5-inhibitor-use-after-radical-prostatectomy
#6
Young Suk Kwon, Nicholas Farber, Ji Woong Yu, Kevin Rhee, Christopher Han, Patrick Ney, Jeong Hee Hong, Paul Lee, Nikhil Gupta, Wun-Jae Kim, Isaac Yi Kim
BACKGROUND: Penile length (PL) shortening is an underreported phenomenon following radical prostatectomy (RP) and risk factors are not fully explored. We aimed to describe longitudinal patterns of PL recovery and evaluate factors predicting complete return to baseline PL. METHODS: PL measurement was performed during a preoperative and postoperative follow-up visits at 7 days and 3, 6, 9, and 12 months. Patients who completely recovered (CR: N = 397) their preoperative stretched PL measured during at least one of their follow-up visits were compared to those with incomplete recovery (IR: N = 131)...
May 9, 2018: BMC Urology
https://www.readbyqxmd.com/read/29739451/reflex-erection-in-the-rat-reciprocal-interplay-between-hemodynamic-and-somatic-events
#7
Alexander Andreev-Andrievskiy, Evgeniia Lagereva, Anfisa Popova
BACKGROUND: Penile erection is a complex reflex under spinal control and modulated by the brain. The hemodynamic events under autonomic control and the perineal muscles somatic activity are interconnected during the reflex erection at the spinal level, however if the afferent feedback on the corpus cavernosum pressure during an erection affects the somatic activity (perineal muscles contractions) and vice versa is not known. This study was aimed to test this hypothesis using a rat model...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29739388/surgical-management-of-large-adrenal-tumors-impact-of-different-laparoscopic-approaches-and-resection-methods-on-perioperative-and-long-term-outcomes
#8
Wei Chen, Yong Liang, Wei Lin, Guang-Qing Fu, Zhi-Wei Ma
BACKGROUND: The indication of retroperitoneal laparoscopic adrenalectomy (RLA) was extended with the retroperitoneal approach and has been wildly accepted and technologically matured. However, the management of large adrenal tumors via this approach still remains controversial. The aim of this study was to perform a comprehensive analysis on the minimally invasive surgical management of larger adrenal tumors. METHODS: A total of 78 patients with large adrenal tumors (> 5 cm) and 97 patients with smaller adrenal tumors (< 5 cm) were enrolled in this study...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29739380/efficacy-analysis-of-self-help-position-therapy-after-holmium-laser-lithotripsy-via-flexible-ureteroscopy
#9
Jie Yang, Rong-Zhen Tao, Pei Lu, Meng-Xing Chen, Xin-Kun Huang, Ke-Liang Chen, Ying-Heng Huang, Xiao-Rong He, Li-di Wan, Jing Wang, Xin Tang, Wei Zhang
BACKGROUND: To observe the efficacy of self-help position therapy (SHPT) after holmium laser lithotripsy via flexible ureteroscopy (FURS). METHODS: From January 2010 to November 2015, 736 nephrolithiasis patients who had received FURS lithotripsy were analyzed retrospectively. In position group, 220 cases accepted SHPT after lithotripsies, and 428 cases as control, coming from another independent inpatient area in the same center. The stone-free status (SFS) between two groups were compared at the 2nd, 4th and 12th week ends by X-ray examinations...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29739377/thrombosed-varicocele-a-rare-cause-for-acute-scrotal-pain-a-case-report
#10
M Raghavendran, A Venugopal, G Kiran Kumar
BACKGROUND: Acute scrotal pain has various causes. Testicular torsion, torsion of appendages and Epididymo-orchitis are common causes, while varicocele thromboses are a rare cause. Varicocele thromboses can occur post operatively or spontaneously. Five cases of post-operative and five cases of spontaneous thromboses have been described till date. The traditional advice in the management of thrombosed varicocele has been to manage it conservatively in all patients by drugs and scrotal support with little description of the surgical treatment...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29739370/gastrointestinal-cancer-and-bilateral-hydronephrosis-resulted-in-a-high-risk-of-ureteral-stent-failure
#11
Mari Ohtaka, Takashi Kawahara, Daiji Takamoto, Taku Mochizuki, Yusuke Hattori, Jun-Ichi Teranishi, Kazuhide Makiyama, Yasuhide Miyoshi, Yasushi Yumura, Masahiro Yao, Hiroji Uemura
BACKGROUND: Urologists frequently encounter malignant ureteral obstruction (MUO) caused by advanced urological or non-urological malignant disease, but the treatment policy is unclear. The present study examined the risk factors for predicting ureteral stent failure in patients with MUO after ureteral stent insertion and the change in the renal function after retrograde ureteral stent insertion in cases of bilateral hydronephrosis. METHODS: A total of 39 patients who required ureteral stent placement for MUO at Yokohama City University Medical Center (Yokohama, Japan) between February 2007 and May 2016 were included in this study...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29739368/impact-of-early-changes-in-serum-biomarkers-following-androgen-deprivation-therapy-on-clinical-outcomes-in-metastatic-hormone-sensitive-prostate-cancer
#12
Hiromi Sato, Shintaro Narita, Norihiko Tsuchiya, Atsushi Koizumi, Taketoshi Nara, Sohei Kanda, Kazuyuki Numakura, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Shigeru Satoh, Kyoko Nomura, Tomonori Habuchi
BACKGROUND: Less evidence is known about the role of early changes in serum biomarker after androgen deprivation therapy (ADT) in patients with metastatic hormone-sensitive prostate cancer (mHSPC). Here we evaluated the impact of pre-treatment prognostic factors and early changes in serum biomarkers on prostate specific antigen (PSA) progression-free and overall survival rates in mHSPC. METHODS: We retrospectively reviewed the medical records of 60 mHSPC patients (median age 72 years) treated with ADT whose laboratory data at baseline and following 12 weeks were available...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29724204/efficacy-and-safety-of-pde5-is-and-%C3%AE-1-blockers-for-treating-lower-ureteric-stones-or-luts-a-meta-analysis-of-rcts
#13
Xifeng Sun, Wei Guan, Haoran Liu, Kun Tang, Libin Yan, Yangjun Zhang, Jin Zeng, Zhiqiang Chen, Hua Xu, Zhangqun Ye
BACKGROUND: Lower ureteric stones and lower urinary tract symptoms are common in urology.Drug treatment is one of standard therapy,but the efficacy was controversial.Thus we aimed to investigate the efficacy and safety of monotherapy or combination therapy of adrenoceptor1 blockers and phosphodiesterase5 inhibitors for treatment. METHODS: Randomized controlled trials up to November 2016 were retrieved from PubMed, the Cochrane Library, Web of Science and Embase...
May 3, 2018: BMC Urology
https://www.readbyqxmd.com/read/29716563/standardised-high-dose-versus-low-dose-cranberry-proanthocyanidin-extracts-for-the-prevention-of-recurrent-urinary-tract-infection-in-healthy-women-paccann-a-double-blind-randomised-controlled-trial-protocol
#14
Babar Asma, Leblanc Vicky, Dudonne Stephanie, Desjardins Yves, Howell Amy, Dodin Sylvie
BACKGROUND: Urinary tract infections (UTIs) are amongst the most common bacterial infections affecting women. Although antibiotics are the treatment of choice for UTI, cranberry derived products have been used for many years to prevent UTIs, with limited evidence as to their efficacy. Our objective is to assess the efficacy of a cranberry extract capsule standardized in A-type linkage proanthocyanidins (PACs) for the prevention of recurrent urinary tract infection. METHODS: We will perform a 1:1 randomized, controlled, double blind clinical trial in women aged 18 years or more who present ≥2 UTIs in 6 months or ≥ 3 UTIs in 12 months...
May 2, 2018: BMC Urology
https://www.readbyqxmd.com/read/29716558/single-stage-laparoscopic-surgery-for-bilateral-organ-tumors-using-a-transumbilical-approach-with-a-zigzag-incision-a-report-of-two-cases
#15
Yoichiro Kato, Renpei Kato, Misato Takayama, Daiki Ikarashi, Mitsutaka Onoda, Tomohiko Matsuura, Mitsugu Kanehira, Ryo Takata, Shigeaki Baba, Toshimoto Kimura, Koki Otsuka, Jun Sugimura, So Omori, Akira Sasaki, Wataru Obara
BACKGROUND: Reduced port laparoscopic surgery (RPLS) is comparable to conventional multiport laparoscopic surgery and has the potential to provide improved cosmesis and decreased pain; as such, it satisfies a growing demand for less invasive surgical procedures. Moreover, a zigzag incision of the umbilicus results in a less visible scar in plastic surgery. Here we report a series of two cases with bilateral organ tumors treated by single-stage RPLS using a combination of a transumbilical approach and a zigzag incision...
May 2, 2018: BMC Urology
https://www.readbyqxmd.com/read/29699543/what-predicts-emotional-response-in-men-awaiting-prostate-biopsy
#16
AnnMarie Groarke, Ruth Curtis, Deirdre M J Walsh, Francis J Sullivan
BACKGROUND: Incidence of prostate cancer is increasing as opportunistic screening becomes widespread and life expectancy rises. Despite screening availability, research reveals conflicting results on medical outcomes, for example, disease specific mortality. However the gold standard in early diagnosis of potentially curable organ confined prostate cancer is transrectal ultrasound-guided systematic prostate biopsy (TRUS-BX). While focus has been given to medical sequalae there is a paucity of research on the psychological impact of biopsy...
April 24, 2018: BMC Urology
https://www.readbyqxmd.com/read/29669553/significant-response-to-nivolumab-for-metastatic-chromophobe-renal-cell-carcinoma-with-sarcomatoid-differentiation-a-case-report
#17
Go Noguchi, Sohgo Tsutsumi, Masato Yasui, Shinji Ohtake, Susumu Umemoto, Noboru Nakaigawa, Masahiro Yao, Takeshi Kishida
BACKGROUND: The treatment of advanced or metastatic renal cell carcinoma (RCC) has drastically changed since the approval of immune checkpoint therapy. Nivolumab is a treatment option for patients with metastatic RCC, previously treated with targeted antiangiogenic therapy. The efficacy of nivolumab for patients with RCC was established by the Checkmate 025 clinical trial. Chromophobe RCC (CRCC) represents around 5% of RCC cases, but non-clear cell RCC (non-ccRCC) subtypes were excluded from the Checkmate 025 clinical trial...
April 18, 2018: BMC Urology
https://www.readbyqxmd.com/read/29636103/role-of-lymph-node-dissection-in-the-management-of-upper-tract-urothelial-carcinomas-a-meta-analysis
#18
Runqi Guo, Yuze Zhu, Gengyan Xiong, Xuesong Li, Kai Zhang, Liqun Zhou
BACKGROUND: Lymph node dissection (LND) is not routinely performed during radical nephroureterectomy (RNU) in upper tract urothelial carcinomas (UTUC) and the role of LND has been controversial. We aim to investigate whether patients with LND had improved survival in UTUC patients. METHODS: We performed a systematic literature search of PubMed, Embase, and Cochrane library for citations published prior to January 2016, describing LND performed among UTUC patients and conducted a standard meta-analysis of survival outcomes...
April 10, 2018: BMC Urology
https://www.readbyqxmd.com/read/29636048/surgical-management-of-urolithiasis-a-systematic-analysis-of-available-guidelines
#19
Valentin Zumstein, Patrick Betschart, Dominik Abt, Hans-Peter Schmid, Cedric Michael Panje, Paul Martin Putora
BACKGROUND: Several societies around the world issue guidelines incorporating the latest evidence. However, even the most commonly cited guidelines of the European Association of Urology (EAU) and the American Urological Association (AUA) leave the clinician with several treatment options and differ on specific points. We aimed to identify discrepancies and areas of consensus between guidelines to give novel insights into areas where low consensus between the guideline panels exists, and therefore where more evidence might increase consensus...
April 10, 2018: BMC Urology
https://www.readbyqxmd.com/read/29587736/comparison-of-clinicopathologic-characteristics-epigenetic-biomarkers-and-prognosis-between-renal-pelvic-and-ureteral-tumors-in-upper-tract-urothelial-carcinoma
#20
Dong Fang, Shiming He, Gengyan Xiong, Nirmish Singla, Zhenpeng Cao, Lei Zhang, Xuesong Li, Liqun Zhou
BACKGROUND: There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis. METHODS: The data of 341 patients with renal pelvic tumors and 271 patients with ureteral tumors who underwent radical nephroureterectomy between 1999 and 2011 were retrospectively reviewed. The clinicopathologic features, gene promoters methylation status and oncologic outcomes were compared...
March 27, 2018: BMC Urology
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