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BMC Urology

Jean-Jacques Body, Roger von Moos, Daniela Niepel, Bertrand Tombal
BACKGROUND: Most patients with advanced prostate cancer develop bone metastases, which often result in painful and debilitating skeletal-related events. Inhibitors of bone resorption, such as bisphosphonates and denosumab, can each reduce the incidence of skeletal-related events and delay the progression of bone pain. However, these agents are associated with an increased risk of hypocalcaemia, which, although often mild and transient, can be serious and life-threatening. Here we provide practical advice on managing the risk of hypocalcaemia in patients with advanced prostate cancer who are receiving treatment with bone resorption inhibitors...
September 20, 2018: BMC Urology
A Ivchenko, R-H Bödeker, C Neumeister, A Wiedemann
BACKGROUND: Elderly people are representative for the patients most likely to be treated with anticholinergics for overactive bladder (OAB). They often receive further drugs with anticholinergic properties for concomitant conditions. This increases the risk for side effects, including central nervous system disorders. Data on comorbidities and baseline anticholinergic burden of OAB patients seen in urological practice is scarce. Therefore, we included an epidemiological survey on these issues in our study which assessed the effectiveness and tolerability of trospium chloride (TC) in established dosages under routine conditions...
September 14, 2018: BMC Urology
Véronique Ouellet, Armen Aprikian, Alain Bergeron, Fadi Brimo, Robert G Bristow, Simone Chevalier, Darrel Drachenberg, Ladan Fazli, Neil E Fleshner, Martin Gleave, Pierre Karakiewicz, Laurence Klotz, Louis Lacombe, Jean-Baptiste Lattouf, Theodorus van der Kwast, Jeremy A Squire, Mathieu Latour, Dominique Trudel, Anne-Marie Mes-Masson, Fred Saad
BACKGROUND: Refinement of parameters defining prostate cancer (PC) prognosis are urgently needed to identify patients with indolent versus aggressive disease. The Canadian Prostate Cancer Biomaker Network (CPCBN) consists of researchers from four Canadian provinces to create a validation cohort to address issues dealing with PC diagnosis and management. METHODS: A total of 1512 radical prostatectomy (RP) specimens from five different biorepositories affiliated with teaching hospitals were selected to constitute the cohort...
September 10, 2018: BMC Urology
Sheng Xue, Sheng-Qun Jiang, Qing-Wen Li, Sheng Wang, Jian Li, Shuai Yang, Hai-Min Zhang, Yun-Fei Xu, Long-Sheng Wang, Jun-Hua Zheng
BACKGROUND: BRAF-activated long non-coding RNA (BANCR) has been associated with various types of cancer. Nevertheless, the role of BANCR in clear cell renal cell carcinoma (ccRCC) is still not fully understood. This study aims to investigate the relationship between ccRCC and BANCR. METHODS: Expression of BANCR in TCGA renal cancer data sets was analyzed. The expression pattern of BANCR in Immortalized normal human proximal tubule epithelial cell line HK-2 and ccRCC cell lines (ACHN, CAKI-1, A498 and 786-O) was detected by real-time quantitative RT-PCR (qRT-PCR)...
September 10, 2018: BMC Urology
Neil M Schultz, Neal D Shore, Simon Chowdhury, Laurence H Klotz, Raoul S Concepcion, David F Penson, Lawrence I Karsh, Hongbo Yang, Bruce A Brown, Arie Barlev, Scott C Flanders
BACKGROUND: This analysis estimated the number needed to treat with enzalutamide versus bicalutamide to achieve one additional patient with chemotherapy-naïve metastatic castration-resistant prostate cancer who would obtain clinical benefit regarding progression-free survival, radiographic progression-free survival, or no prostate-specific antigen progression at 1 and 2 years following treatment initiation. METHODS: Clinical event rates were obtained from the STRIVE (NCT01664923) and TERRAIN (NCT01288911) trials, and the number needed to treat was the inverse of the absolute rate difference between the event rates of enzalutamide and bicalutamide...
September 6, 2018: BMC Urology
Jameel Nazir, Zalmai Hakimi, Florent Guelfucci, Amine Khemiri, Francis Fatoye, Ana María Mora Blázquez, Marta Hernández González
BACKGROUND: Persistence on-treatment with antimuscarinics in patients with overactive bladder (OAB) is reported to be sub-optimal. This retrospective, longitudinal, observational cohort study assessed treatment persistence with β3 -adrenoceptor agonists (i.e. mirabegron) and antimuscarinics, both classes of OAB pharmacotherapy, in patients with OAB in Spain. METHODS: Adults who received mirabegron or an antimuscarinic in routine clinical practice (1 June-31 October 2014), were identified from anonymised prescription data within the Spanish Cegedim Electronic Medical Records database...
September 4, 2018: BMC Urology
Marvin J Van Every, Garrett Dancik, Venki Paramesh, Grzegorz T Gurda, David R Meier, Steven E Cash, Craig S Richmond, Sunny Guin
BACKGROUND: We present a rare case where distant metastasis of a low grade bladder tumor was observed. We carried out detailed genomic analysis and cell based experiments on patient tumor samples to study tumor evolution, possible cause of disease and provide personalized treatment strategies. CASE PRESENTATION: A man with a smoking history was diagnosed with a low-grade urothelial carcinoma of the bladder and a concurrent high-grade upper urinary tract tumor. Seven years later he had a lung metastasis...
September 3, 2018: BMC Urology
Johannes Bründl, Sabine Wallinger, Johannes Breyer, Florian Weber, Matthias Evert, Nikolaos Theodoros Georgopoulos, Bernd Rosenhammer, Maximilian Burger, Wolfgang Otto, Peter Rubenwolf
BACKGROUND: To study the expression pattern, localisation and potential clinical significance of aquaporin water channels (AQP) both in prostate cancer (PC) cell lines and in benign and malignant human prostate tissue. METHODS: The AQP transcript and protein expression of HPrEC, LNCaP, DU-145 and PC3 cell lines was investigated using reverse transcriptase polymerase chain reaction (RT-PCR) and immunofluorescence (IF) microscopy labelling. Immunohistochemistry (IHC) was performed to assess AQP protein expression in surgical specimens of benign prostatic hyperplasia as well as in PC...
September 3, 2018: BMC Urology
Yin-Chien Ou, Che-Yuan Hu, Hong-Lin Cheng, Wen-Horng Yang
BACKGROUND: To explore the feasibility and long-term outcomes of renal preservation in a retrospective cohort of patients with ureteral urothelial carcinoma undergoing total ureterectomy with ileal-ureteral substitution. METHODS: A retrospective review of the data from patients treated with total ureterectomy with ileal-ureteral substitution from 1988 to 2016 was performed. The pre-operative oncological status, long-term oncological outcome, long-term renal functional outcome, early and late complications were analyzed...
August 31, 2018: BMC Urology
Jeffrey D Redshaw, Sara M Lenherr, Sean P Elliott, John T Stoffel, Jeffrey P Rosenbluth, Angela P Presson, Jeremy B Myers
BACKGROUND: Neurogenic bladder (NGB) dysfunction after spinal cord injury (SCI) is generally irreversible. Preliminary animal and human studies have suggested that initiation of sacral neuromodulation (SNM) immediately following SCI can prevent neurogenic detrusor overactivity and preserve bladder capacity and compliance. We designed a multicenter randomized clinical trial to evaluate the effectiveness of early SNM after acute SCI. METHODS/DESIGN: The scientific protocol comprises a multi-site, randomized, non-blinded clinical trial...
August 29, 2018: BMC Urology
Helen Quirk, Derek J Rosario, Liam Bourke
BACKGROUND: Our understanding of effective perioperative supportive interventions for patients undergoing cystectomy procedures and how these may affect short and long-term health outcomes is limited. METHODS: Randomised controlled trials involving any non-surgical, perioperative interventions designed to support or improve the patient experience for patients undergoing cystectomy procedures were reviewed. Comparison groups included those exposed to usual clinical care or standard procedure...
August 24, 2018: BMC Urology
Yumeng Zhang, Tianjia Ma, Guangfeng Shao, Zhiying Xiao
BACKGROUND: Uretero-fallopian fistula (UFF) is a very rare surgery complication which usually happens after surgeries of fallopian tube or ureter. There has been no report of interventional operations of fallopian tube causing UFF. CASE PRESENTATION: A 41-year-old female received fallopian tube embolization for birth control. After that she noticed "clear vaginal discharge". She neglected that symptom for 7 years, until a sudden onset of abdominal pain brought her to the ER...
August 22, 2018: BMC Urology
Ahmed S Zakaria, Alice Dragomir, Fadi Brimo, Wassim Kassouf, Simon Tanguay, Armen Aprikian
BACKGROUND: The benefits of PSA-based screening for prostate cancer (PCa) are controversial. The Canadian and American Task Forces on Preventive Health Care (CTFPHC & USPSTF) have released recommendations against the use of routine PSA-based screening for any men. We thought to assess the impact of these recommendations on the outcomes and trends of prostate needle biopsies. METHODS: A complete chart review was conducted for all men who received prostate needle biopsies at McGill University Health Center between 2010 and 2016...
August 20, 2018: BMC Urology
Risa Shinoki, Teppei Takeshima, Koichiro Horie, Toshihiro Matsui, Ayako Horita, Ikuo Saito, Kotaro Hirai
BACKGROUND: Aspergillosis in patients with impaired immunity usually presents with invasive pulmonary infection and dissemination to a variety of organs via hematogenous spread. Aspergilloma in the retroperitoneal cavity is a rare disease with only a few cases reported in the literature. To the best of our knowledge, the present case of a retroperitoneal aspergilloma with no surgical history is only the second report in the literature. CASE PRESENTATION: A 65 year-old man, who had been receiving immunosuppressive treatment for rheumatoid arthritis with vasculitis for 9 years, was referred to the Urology Department with a retroperitoneal mass...
July 31, 2018: BMC Urology
Young Saing Kim, Kyung Kim, Ghee-Young Kwon, Su Jin Lee, Se Hoon Park
BACKGROUND: Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasive UC who received radical resection. METHODS: We analyzed surgical tumor samples from 74 UC patients who had received radical cystectomy (n = 40) or ureteronephrectomy (n = 34). Ion AmpliSeq Cancer Hotspot Panel v2 and nCounter Copy Number Variation Assay were used to detect FGFR3 aberrations...
July 31, 2018: BMC Urology
Martin L Brady, King Scott Coffield, Thomas J Kuehl, Raghu Raghavan, V O Speights, Belur Patel, Scott Wilson, Mike Wilson, Rick M Odland
BACKGROUND: New biologic therapies directly injected into the prostate are in clinical trials for prostatic diseases. There is a need to understand distribution of injected therapies as a function of prostatic anatomy, physiology, and device design. METHODS: A needle with a porous length of customizable-length was tested and its performance compared with a standard needle. Injections of magnetic resonance contrast reagent were placed into ex-vivo human prostates after surgical excision in standard of care therapy for invasive bladder cancer patients...
July 28, 2018: BMC Urology
Hwa Yeon Sun, Young Myoung Ko, Seung Wook Lee, Bora Lee, Jae Heon Kim
BACKGROUND: Reduced clinical exposure to urology at the undergraduate or internship level is the main explanation for the marked decrease in applicants to urology residencies. This manuscript was to access the application rate for urology specialty compared with that of other specialties and to investigate the relationship between the decreasing trend in urology applications and social interest using internet trend tests. METHODS: We reviewed data collected by the Korean Hospital Association from 2007 to 2014...
July 24, 2018: BMC Urology
Xujun Sheng, Ding Xu, Yu Wu, Yongjiang Yu, Jianhua Chen, Jun Qi
BACKGROUND: The current research aims to evaluate the risk factors of urethrocutaneous fistula after hypospadias surgery among the youth in China. METHODS: One hundred twenty hypospadias patients were enrolled in our study. All of them were defined as Tanner 4 or 5. The information collected from the participants include age, urethral operation history, urinary comorbidities before operation, urine test before operation, body temperature before and after operation, type of surgical repair, chordee degree, urethral defect length and whether received vesicostomy after surgery or not...
July 24, 2018: BMC Urology
Lucio Gnessi, Filomena Scarselli, Maria Giulia Minasi, Stefania Mariani, Carla Lubrano, Sabrina Basciani, Pier Francesco Greco, Mikiko Watanabe, Giorgio Franco, Alessio Farcomeni, Ermanno Greco
BACKGROUND: To provide indicators for the likelihood of sperm retrieval in patients undergoing testicular sperm extraction is a major issue in the management of male infertility by TESE. The aim of our study was to determine the impact of different parameters, including testicular histopathology, on sperm retrieval in case of reoperation in patients undergoing testicular sperm extraction. METHODS: We retrospectively analyzed 486 patients who underwent sperm extraction for intracytoplasmic sperm injection and testicular biopsy...
July 4, 2018: BMC Urology
Cosimo De Nunzio, Fabrizio Presicce, Riccardo Lombardo, Alberto Trucchi, Mariangela Bellangino, Andrea Tubaro, Egidio Moja
BACKGROUND: Even though evidence based medicine, guidelines and algorithms still represent the pillars of the management of chronic diseases (i.e: hypertension, diabetes mellitus), a patient centred approach has been recently proposed as a successful strategy, in particular to improve drug adherence. Aim of the present review is to evaluate the unmet needs in LUTS/BPH management and the possible impact of a patient centered approach in this setting. METHODS: A National Center for Biotechnology Information (NCBI) PubMed search for relevant articles published from January 2000 until December 2016 was performed by combining the following MESH terms: patients centred medicine, patient centered care, person centered care, patient centered outcomes, value based care, shared decision making, male, Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, treatment...
June 26, 2018: BMC Urology
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