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BMC Musculoskeletal Disorders

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https://www.readbyqxmd.com/read/29789008/pharmacological-effects-of-n-2-2-2-2-6-dichlorophenyl-amino-phenyl-acetyl-oxy-ethyl-hyaluronamide-diclofenac-etalhyaluronate-si-613-a-novel-sodium-hyaluronate-derivative-chemically-linked-with-diclofenac
#1
Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda, Kenji Miyamoto
BACKGROUND: Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with diclofenac (DF), diclofenac etalhyaluronate (SI-613), which is a potentially safer and more effective treatment for OA knee pain. In this study, we evaluated the pharmacological effects of SI-613 in experimental arthritis models. METHODS: We compared the analgesic and anti-inflammatory effects of intra-articularly administered SI-613, hyaluronic acid (HA), and of orally administered diclofenac sodium (DF-Na) in rat silver nitrate-induced arthritis model and rabbit antigen-induced arthritis model...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29789004/a-population-based-study-of-the-risk-of-osteoporosis-and-fracture-with-dutasteride-and-finasteride
#2
Tony Antoniou, Erin M Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M-W Ho, Muhammad M Mamdani, David N Juurlink
BACKGROUND: Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is unknown. We compared the risk of osteoporosis and fractures in older men treated with dutasteride or finasteride. METHODS: We conducted a population-based retrospective cohort study with high-dimensional propensity score matching of Ontario men aged 66 years or older who started treatment with dutasteride or finasteride between January 1, 2006 and December 31, 2012...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788969/psychosocial-predictors-for-outcome-after-total-joint-arthroplasty-a-prospective-comparison-of-hip-and-knee-arthroplasty
#3
Marion Lindner, Olaf Nosseir, Anett Keller-Pliessnig, Per Teigelack, Martin Teufel, Sefik Tagay
BACKGROUND: As findings regarding predictors for good outcome after total joint arthroplasty are highly inconsistent, aim of this study was to investigate the influence of the psychosocial variables sense of coherence and social support as well as mental distress on physical outcome after surgery. It should be investigated if different predictors are important in patients after total hip arthroplasty (THA) compared to patients after total knee arthroplasty (TKA). METHODS: In a prospective design, 44 patients undergoing THA and 61 patients undergoing TKA were examined presurgery and 6 and 12 weeks after surgery using WOMAC (disease-specific outcome), SF-36 (health-related quality of life), BSI (psychological distress), SOC-13 (sense of coherence), and F-SozU (social support)...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788950/construct-validity-and-reliability-of-the-finnish-version-of-the-knee-injury-and-osteoarthritis-outcome-score
#4
Juhani Multanen, Mikko Honkanen, Arja Häkkinen, Ilkka Kiviranta
BACKGROUND: The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a commonly used knee assessment and outcome tool in both clinical work and research. However, it has not been formally translated and validated in Finnish. The purpose of this study was to translate and culturally adapt the KOOS questionnaire into Finnish and to determine its validity and reliability among Finnish middle-aged patients with knee injuries. METHODS: KOOS was translated and culturally adapted from English into Finnish...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788949/range-of-motion-after-total-knee-arthroplasty-in-hemophilic-arthropathy
#5
Radovan Kubeš, Peter Salaj, Rastislav Hromádka, Josef Včelák, Aleš Antonín Kuběna, Monika Frydrychová, Štěpán Magerský, Michal Burian, Martin Ošťádal, Jan Vaculik
BACKGROUND: Outcomes of total knee replacement in cases of hemophilic patients are worse than in patients who undergo operations due to osteoarthritis. Previous publications have reported varying rates of complications in hemophilic patients, such as infection and an unsatisfactory range of motion, which have influenced the survival of prostheses. Our retrospective study evaluated the data of hemophilic patients regarding changes in the development of the range of motion. METHODS: The data and clinical outcomes of 72 total knee replacements in 45 patients with hemophilia types A and B were reviewed retrospectively...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788945/musculoskeletal-disorders-among-preschool-teachers-analyzing-the-relationships-among-relational-demands-work-meaning-and-intention-to-leave-the-job
#6
Daniela Converso, Sara Viotti, Ilaria Sottimano, Vincenza Cascio, Gloria Guidetti
BACKGROUND: Based on the conservation of resource (COR) theory by Hobfoll, the aim of the present study was to test whether the relationships among relational demands, work meaning, and intention to leave vary as a function of the presence of musculoskeletal disorders (MSDs). METHOD: The study was cross-sectional and non-randomized. Analyses were carried out on a dataset consisting of 429 preschool teachers, who filled out a self-report questionnaire. Of them, 238 reported a MSD diagnosis and 191 were free form MSDs...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788942/use-of-autologous-bone-marrow-stem-cell-implantation-for-osteonecrosis-of-the-knee-in-sickle-cell-disease-a-preliminary-report
#7
Gildasio Daltro, Bruno Adelmo Franco, Thiago Batista Faleiro, Davi Araujo Veiga Rosário, Paula Braga Daltro, Roberto Meyer, Vitor Fortuna
BACKGROUND: The purpose of our study was to evaluate safety, feasibility and clinical results of bone marrow mononuclear cell (BMC) implantation for early-stage osteonecrosis of the knee (OK) secondary to sickle cell disease. METHODS: Thirty-three SCD patients (45 knees) with OK treated with BMC implantation in the osteonecrotic lesion were clinically and functionally evaluated through the American Knee Society Clinical Score (KSS), Knee Functional Score (KFS) and Numeric Rating Scale (NRS) pain score...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788940/two-cases-in-which-3d-mri-was-used-to-differentiate-between-a-disc-mass-that-mimics-a-tumor-and-neurinoma
#8
Jingyu Jia, Qiangqiang Wei, Tianlong Wu, Dingwen He, Xigao Cheng
BACKGROUND: Since disc sequestration that mimics a tumor is rare and sometimes presents with an atypical appearance upon magnetic resonance imaging (MRI), it is often confused with other more common epidural and intradural neoplasms, particularly neurinoma. Open surgery is necessary due to the difficult of achieving a definitive diagnosis using computed tomography, MRI, and gadolinium- enhanced MRI prior to operation. Herein, we describe the use of coronal MR images of 3D fast-field echo with water selective excitation in the diagnosis of disc sequestration mimicking a tumor...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788936/association-between-stress-fracture-incidence-and-predicted-body-fat-in-united-states-army-basic-combat-training-recruits
#9
Joseph J Knapik, Marilyn A Sharp, Scott J Montain
BACKGROUND: A stress fracture (SF) is a highly debilitating injury commonly experienced in United States Army Basic Combat Training (BCT). Body fat (BF) may be associated with this injury but previous investigations (in athletes) have largely used SF self-reports and lacked sufficient statistical power. This investigation developed an equation to estimate %BF and used that equation to examine the relationship between %BF and SF risk in BCT recruits. METHODS: Data for the %BF predictive equation involved 349 recruits with BF obtained from dual-energy X-ray absorptiometry...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29776450/the-role-of-surgical-margins-in-atypical-lipomatous-tumours-of-the-extremities
#10
Jessica Rauh, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson, Hans Roland Dürr
BACKGROUND: Atypical lipomatous tumours (ALT) are common adipocytic tumours. Due to their large size and deep-seated location, wide resection might result in severe functional deficits. The question which margins should be aimed is hence discussed controversially. METHODS: Forty consecutive patients underwent limb-sparing resections. Margins were defined as R0 (wide resection), R1 (marginal resection) or R2 if tumour was left. All patients were followed for evidence of local recurrence or remote metastases...
May 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29776411/a-study-of-the-factors-associated-with-cervical-spinal-disc-degeneration-with-a-focus-on-bone-metabolism-and-amino-acids-in-the-japanese-population-a-cross-sectional-study
#11
Kanichiro Wada, Toshihiro Tanaka, Gentaro Kumagai, Hitoshi Kudo, Toru Asari, Daisuke Chiba, Seiya Ota, Keita Kamei, On Takeda, Shigeyuki Nakaji, Yasuyuki Ishibashi
BACKGROUND: The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze the factors related to disc degeneration in the Japanese population. METHODS: Three hundred and forty-four Japanese general residents underwent investigations, including magnetic resonance imaging of the cervical spine, in our health check project...
May 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29769120/a-controlled-before-after-study-to-evaluate-the-effect-of-a-clinician-led-policy-to-reduce-knee-arthroscopy-in-nsw
#12
H Y Chen, I A Harris, K Sutherland, J-F Levesque
BACKGROUND: Clinical evidence shows knee arthroscopy has little benefit for degenerative conditions and considerable variation in the incidence of knee arthroscopy in Australia has been identified. This study aimed to evaluate a clinician-led evidence-based policy which was implemented in one local health district in New South Wales (NSW) in 2012 to reduce the use of knee arthroscopy for patients aged 50 years or over. METHODS: Trends in rates and volume of knee arthroscopy for patients 50 years or over in NSW between 2004 and 2015 by district were examined...
May 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29769108/correlation-between-the-sagittal-spinopelvic-alignment-and-degenerative-lumbar-spondylolisthesis-a-retrospective-study
#13
Qi Lai, Tian Gao, Xin Lv, Xuqiang Liu, Zongmiao Wan, Min Dai, Bin Zhang, Tao Nie
BACKGROUND: Pain and disability associated with degenerative lumbar spondylolisthesis (DLS) results in significant burden on both the patients' quality of life and healthcare costs. Currently, there is controversy regarding the specificity of spinopelvic measures of sagittal plane alignment with respect to DLS. Moreover, the correlation among spinopelvic parameters of sagittal plane alignment remains to be clarified. Our aim in this study was to compare these measurements between patients with single-segment DLS at L5 and a control group with no history of DLS...
May 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29769058/efficacy-of-standardized-training-on-a-virtual-reality-simulator-to-advance-knee-and-shoulder-arthroscopic-motor-skills
#14
Stefan Rahm, Karl Wieser, David E Bauer, Felix Wa Waibel, Dominik C Meyer, Christian Gerber, Sandro F Fucentese
BACKGROUND: Most studies demonstrated, that training on a virtual reality based arthroscopy simulator leads to an improvement of technical skills in orthopaedic surgery. However, how long and what kind of training is optimal for young residents is unknown. In this study we tested the efficacy of a standardized, competency based training protocol on a validated virtual reality based knee- and shoulder arthroscopy simulator. METHODS: Twenty residents and five experts in arthroscopy were included...
May 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29769051/knee-dgemric-at-7-t-comparison-against-1-5-t-and-evaluation-of-t-1-mapping-methods
#15
Pernilla Peterson, Carl Johan Tiderius, Emma Olsson, Björn Lundin, Lars E Olsson, Jonas Svensson
BACKGROUND: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development...
May 16, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29764409/quadriceps-combined-with-hip-abductor-strengthening-versus-quadriceps-strengthening-in-treating-knee-osteoarthritis-a-study-protocol-for-a-randomized-controlled-trial
#16
Yujie Xie, Chi Zhang, Wei Jiang, Juan Huang, Lili Xu, Guoyin Pang, Haiyan Tang, Ruyan Chen, Jihua Yu, Shengmin Guo, Fangyuan Xu, Jianxiong Wang
BACKGROUND: Lower limb strengthening, especially the quadriceps training, is of much necessity for patients with knee osteoarthritis (KOA). Previous studies suggest that strengthening of the hip muscles, especially the hip abductor, can potentially relieve the KOA-associated symptoms. Nevertheless, the effects of quadriceps combined with hip abductor strengthening remain unclear. Therefore, the current randomized controlled trial is designed aiming to observe whether quadriceps in combination with hip abductor strengthening can better improve the function and reduce pain in KOA patients than quadriceps training alone...
May 15, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29759083/hypertrophic-osteoarthropathy-mimicking-a-reactive-arthritis-a-case-report-and-review-of-the-literature
#17
Francesco Bozzao, Stella Bernardi, Franca Dore, Lorenzo Zandonà, Fabio Fischetti
BACKGROUND: Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of skin and periosteal tissues of the extremities. It can be a rare hereditary disease (pachydermoperiostosis) or can be secondary to various diseases, though mostly lung malignancies. Here, we report an unusual clinical presentation of HOA. CASE PRESENTATION: A 77-year-old man presented with fever, diarrhea, and an oligoarthritis involving the left knee and the ankles...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29759081/comparative-study-of-the-paraspinal-muscles-after-ovf-between-the-insufficient-union-and-sufficient-union-using-mri
#18
Marina Katsu, Tetsuro Ohba, Shigeto Ebata, Hirotaka Haro
BACKGROUND: Identification of poor prognostic factors for OVF is important but has not yet been clearly established. Despite paraspinal muscles could play an important role in the etiology of OVF, what influence time-dependent changes in paraspinal muscles have after OVF, and the impact on conservative treatments for patients who have an OVF remain largely unknown. The purposes of this study were to (1) evaluate time-dependent changes of the paraspinal musculature using MRI after injury in patients with osteoporotic vertebral fractures (OVFs), and (2) compare paraspinal muscles between conservatively treated patients with OVF who have successful union and those failed to conservative treatment...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29759066/prevalence-and-comorbidity-of-osteoporosis-a-cross-sectional-analysis-on-10-660-adults-aged-50-years-and-older-in-germany
#19
Marie-Therese Puth, Manuela Klaschik, Matthias Schmid, Klaus Weckbecker, Eva Münster
BACKGROUND: Knowledge on prevalence of osteoporosis stratifying for socioeconomic background is insufficient in Germany. Little is known in Europe about other diseases that go along with it although these aspects are important for implementing effective public health strategies. METHODS: This cross-sectional analysis was based on the national telephone survey "German Health Update" (GEDA 2012) performed in 2012/2013. GEDA 2012 provides information on self-reported diseases and sociodemographic characteristics for nearly 20,000 adults...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29759063/discontinuation-of-the-pace-plus-trial-problems-in-patient-recruitment-in-general-practice
#20
M Schreijenberg, P A J Luijsterburg, Y D M Van Trier, D Rizopoulos, M A Koopmanschap, L Voogt, C G Maher, B W Koes
BACKGROUND: The PACE Plus trial was a multi-center, double-blinded, superiority randomized controlled trial (RCT) conducted in patients from Dutch general practice to investigate the efficacy of paracetamol and NSAIDs in acute non-specific low back pain (LBP). Because insufficient numbers of patients could be recruited (only four out of the required 800 patients could be recruited over a period of 6 months), the trial was prematurely terminated in February 2017, 6 months after the start of recruitment...
May 14, 2018: BMC Musculoskeletal Disorders
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