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BMC Pulmonary Medicine

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https://www.readbyqxmd.com/read/29343236/barriers-to-timely-diagnosis-of-interstitial-lung-disease-in-the-real-world-the-intensity-survey
#1
Gregory P Cosgrove, Pauline Bianchi, Sherry Danese, David J Lederer
BACKGROUND: The diagnosis of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD) presents significant clinical challenges. To gain insights regarding the diagnostic experience of patients with ILD and to identify potential barriers to a timely and accurate diagnosis, we developed an online questionnaire and conducted a national survey of adults with a self-reported diagnosis of ILD. METHODS: A pre-specified total of 600 subjects were recruited to participate in a 40-question online survey...
January 17, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29338740/is-sweat-testing-for-cystic-fibrosis-feasible-in-patients-with-down-syndrome
#2
Katharina Ruf, Antonia Demerath, Helge Hebestreit, Steffen Kunzmann
BACKGROUND: Recurrent airway infections are common in patients with Down's syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing - the gold standard to diagnose CF - has been questioned in DS as false positive results have been reported. However, these reports are based on measurements of sweat osmolality or sodium concentrations, not chloride concentrations. This study analyses sweat secretion rate and chloride concentration in sweat samples of patients with DS in comparison to healthy controls...
January 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29338717/risk-factors-for-acute-respiratory-infections-in%C3%A2-children-under-five-years-attending-the-bamenda-regional-hospital-in-cameroon
#3
Alexis A Tazinya, Gregory E Halle-Ekane, Lawrence T Mbuagbaw, Martin Abanda, Julius Atashili, Marie Therese Obama
BACKGROUND: Acute respiratory infections (ARI) are a leading cause of morbidity and mortality in under-five children worldwide. About 6.6 million children less than 5 years of age die every year in the world; 95% of them in low-income countries and one third of the total deaths is due to ARI. This study aimed at determining the proportion of acute respiratory infections and the associated risk factors in children under 5 years visiting the Bamenda Regional Hospital in Cameroon. METHODS: A cross-sectional analytic study involving 512 children under 5 years was carried out from December 2014 to February 2015...
January 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29338706/miliary-tuberculosis-with-co-existing-pulmonary-cryptococcosis-in-non-hiv-patient-without-underlying-diseases-a-case-report
#4
Toyomitsu Sawai, Takumi Nakao, Satoru Koga, Shotaro Ide, Sumako Yoshioka, Nobuko Matsuo, Hiroshi Mukae
BACKGROUND: Tuberculosis and cryptococcosis co-infection usually occurs in immunosuppressed patients with impaired cell-mediated immunity. However, there are few reports about such co-infection in non-HIV patients without underlying diseases. Here, we report a case of miliary tuberculosis with co-existing pulmonary cryptococcosis in non-HIV patient without underlying diseases. CASE PRESENTATION: An 84-year-old Asian female presented to our hospital with complaints of a 1-week history of abdominal pain and appetite loss...
January 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29321018/management-and-attitudes-about-ipf-idiopathic-pulmonary-fibrosis-among-physicians-from-latin-america
#5
Iván Cherrez-Ojeda, Vincent Cottin, Juan Carlos Calderón, César Delgado, Erick Calero, Daniel Simanca-Racines, Silvia Quadrelli, Annia Cherrez
BACKGROUND: The aim of our study was to assess current practice patterns and attitudes towards diagnosis and management of idiopathic pulmonary fibrosis (IPF) patients in Latin America. METHODS: A Cross-sectional survey was developed and up to 455 physicians were enrolled. We used a rigorous method of validation using the translated version of the AIR Survey. RESULTS: Mean age was 47.5 years (SD 12.6) with 20.4 years (SD 12.3) of practice...
January 10, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29316890/risk-factors-of-postoperative-pulmonary-complications-in-patients-with-asthma-and-copd
#6
Takanori Numata, Katsutoshi Nakayama, Satoko Fujii, Yoko Yumino, Nayuta Saito, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya, Yumi Kaneko, Kazuyoshi Kuwano
BACKGROUND: Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore, it is necessary to evaluate perioperative management using new inhalant drugs in patients with obstructive pulmonary diseases. METHODS: April 2014 through March 2015, 346 adult patients with pulmonary diseases (257 asthma, 89 chronic obstructive pulmonary disease (COPD)) underwent non-pulmonary surgery except cataract surgery in our university hospital...
January 9, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29310638/the-use-of-an-alternate-side-lying-positioning-strategy-during-inhalation-therapy-does-not-prolong-nebulisation-time-in-adults-with-cystic-fibrosis-a-randomised-crossover-trial
#7
Ruth L Dentice, Mark R Elkins, Genevieve M Dwyer, Peter T P Bye
BACKGROUND: Inhalation of nebulised medications is performed in upright sitting to maximise lung volumes. The pattern of deposition is poor for inhaled medications in people with Cystic Fibrosis. The pattern tends to be non-uniform and typically the upper lobes receive a reduced dose compared to the rest of the lung. One strategy that has been proposed as having the potential to improve homogeneity of deposition is to adopt an alternate side lying position for the inhalation procedure...
January 8, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29304775/thin-section-computed-tomography-determined-usual-interstitial-pneumonia-pattern-affects-the-decision-making-process-for-resection-in-newly-diagnosed-lung-cancer-patients-a-retrospective-study
#8
Naozumi Hashimoto, Akira Ando, Shingo Iwano, Koji Sakamoto, Shotaro Okachi, Asuka Matsuzaki, Yu Okada, Kenji Wakai, Kohei Yokoi, Yoshinori Hasegawa
BACKGROUND: There is only limited information on the impact of thin-section computed tomography (TSCT)-determined usual interstitial pneumonia (UIP) pattern in the decision-making for resection in newly diagnosed lung cancer patients. METHODS: In this retrospective analysis, data were reviewed from 499 newly diagnosed lung cancer patients who received bronchoscopy between 2010 and 2014. The clinical impact of TSCT-determined UIP pattern on the decision-making process for resection in this cohort was evaluated...
January 5, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29301525/annexin-a1-in-plasma-from-patients-with-bronchial-asthma-its-association-with-lung-function
#9
Sun-Hye Lee, Pureun-Haneul Lee, Byeong-Gon Kim, Hyun-Jeong Seo, Ae-Rin Baek, Jong-Sook Park, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
BACKGROUND: Annexin-A1 (ANXA1) is a glucocorticoid-induced protein with multiple actions in the regulation of inflammatory cell activation. The anti-inflammatory protein ANXA1 and its N-formyl peptide receptor 2 (FPR2) have protective effects on organ fibrosis. However, the exact role of ANXA1 in asthma remains to be determined. The aim of this study was to identify the role of ANXA1 in bronchial asthma. METHODS: In mice sensitized and challenged with ovalbumin (OVA-OVA mice) and mice sensitized with saline and challenged with air (control mice), we investigated the potential links between ANXA1 levels and bronchial asthma using ELISA, immunoblotting, and immunohistochemical staining...
January 4, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29284447/adjunctive-corticosteroid-therapy-for-inpatients-with-mycoplasma-pneumoniae-pneumonia
#10
Masato Tashiro, Kiyohide Fushimi, Kei Kawano, Takahiro Takazono, Tomomi Saijo, Kazuko Yamamoto, Shintaro Kurihara, Yoshifumi Imamura, Taiga Miyazaki, Katsunori Yanagihara, Hiroshi Mukae, Koichi Izumikawa
BACKGROUND: There is conflicting evidence regarding the benefit of adjunctive corticosteroid therapy in patients with Mycoplasma pneumoniae pneumonia. We hypothesised that corticosteroid therapy could reduce mortality and length of stay (LOS) in such patients. METHODS: Adult patients with M. pneumoniae pneumonia from January 2010 to December 2013 were identified from the Japanese Diagnosis Procedure Combination inpatient database. The effects of low-dose and high-dose corticosteroid therapies on mortality, LOS, drug costs and hyperglycaemia requiring insulin treatment were evaluated using propensity score analyses...
December 29, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29282101/association-of-physical-activity-with-lung-function-in-lung-healthy-german-adults-results-from-the-kora-ff4-study
#11
Agnes Luzak, Stefan Karrasch, Barbara Thorand, Dennis Nowak, Rolf Holle, Annette Peters, Holger Schulz
BACKGROUND: In lung disease, physical activity (PA) yields beneficial health effects, but its association with the function of healthy lungs has rarely been studied. We investigated the association of accelerometer-based PA with spirometric indices, maximal inspiratory mouth pressure (PImax) and lung diffusion capacity in lung-healthy adults. METHODS: In total, 341 apparently lung-healthy participants from the population-based KORA (Cooperative Health Research in the Region of Augsburg) FF4 cohort study (45% male, aged 48-68 years, 47% never smokers) completed lung function testing and wore ActiGraph accelerometers over a one week period at the hip...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29282042/overexpression-of-emmprin-is-associated-with-lymph-node-metastasis-and-advanced-stage-of-non-small-cell-lung-cancer-a-retrospective-study
#12
Bing Liu, Zhaohui Wan, Baowei Sheng, Yong Lin, Tian Fu, Qingdi Zeng, Congcong Qi
BACKGROUND: Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (NSCLC) and its clinical value for the diagnosis of NSCLC. METHODS: The expression of EMMPRIN was examined using immunohistochemistry and enzyme-linked immunosorbent assay. The clinical value of EMMPRIN was evaluated by drawing a receiver operating characteristic (ROC) curve...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29282040/case-report-atypical-presentation-of-vancomycin-induced-dress-syndrome-a-case-report-and-review-of-the-literature
#13
Olivia Wilcox, Mohamed Hassanein, John Armstrong, Nader Kassis
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and skin rash, and rapidly progress to multiple organ failures. Vancomycin is a rare drug to cause DRESS syndrome with 23 cases reported to date. CASE PRESENTATION: We described a case of a 39 year-old man who was treated with vancomycin for osteomyelitis of the foot...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29282039/plasma-levels-of-alarmin-hnps-1-3-associate-with-lung-dysfunction-after-cardiac-surgery-in-children
#14
XiWang Liu, QiXing Chen, YuJia Luo, YaoQin Hu, DengMing Lai, XiaoLe Zhang, XiangHong Zhang, JianGen Yu, XiangMing Fang, Qiang Shu
BACKGROUND: Early onset of lung injury is considerable common after cardiac surgery and is associated with increasing in morbidity and mortality, but current clinical predictors for the occurrence of this complication always have limited positive warning value. This study aimed to evaluate whether elevated plasma levels of human neutrophil peptides (HNPs) 1-3 herald impaired lung function in infants and young children after cardiac surgery necessitating cardiopulmonary bypass (CPB). METHODS: Consecutive children younger than 3 years old who underwent cardiac surgery were prospectively enrolled...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29282032/riociguat-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-results-from-an-early-access-study
#15
Vallerie V McLaughlin, Pavel Jansa, Jens E Nielsen-Kudsk, Michael Halank, Gérald Simonneau, Ekkehard Grünig, Silvia Ulrich, Stephan Rosenkranz, Miguel A Gómez Sánchez, Tomás Pulido, Joanna Pepke-Zaba, Joan Albert Barberá, Marius M Hoeper, Jean-Luc Vachiéry, Irene Lang, Francine Carvalho, Christian Meier, Katharina Mueller, Sylvia Nikkho, Andrea M D'Armini
BACKGROUND: Following positive results from the Phase III CHEST-1 study in patients with inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH), the Phase IIIb CTEPH early access study (EAS) was designed to assess the safety and tolerability of riociguat in real-world clinical practice, as well as to provide patients with early access to riociguat before launch. Riociguat is approved for the treatment of inoperable and persistent/recurrent CTEPH. METHODS: We performed an open-label, uncontrolled, single-arm, early access study in which 300 adult patients with inoperable or persistent/recurrent CTEPH received riociguat adjusted from 1 mg three times daily (tid) to a maximum of 2...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29262802/implication-of-species-change-of-nontuberculous-mycobacteria-during-or-after-treatment
#16
Jong Sik Lee, Jong Hyuk Lee, Soon Ho Yoon, Taek Soo Kim, Moon-Woo Seong, Sung Koo Han, Jae-Joon Yim
BACKGROUND: Co-existence or subsequent isolation of multiple nontuberculous mycobacteria (NTM) species in same patient has been reported. However, clinical significance of these observations is unclear. The aim of this study was to determine clinical implications of changes of NTM species during or after treatment in patients with NTM lung disease. METHODS: Patients with NTM lung disease, who experienced changes of NTM species during treatment or within 2 years of treatment completion between January 1, 2009 and December 31, 2015, were included in the analysis...
December 20, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29258484/lung-ultrasonography-to-diagnose-community-acquired-pneumonia-in-children
#17
Nicola Principi, Andrea Esposito, Caterina Giannitto, Susanna Esposito
BACKGROUND: Early diagnosis of community-acquired pneumonia (CAP) is essential to reduce the total burden of this disease. Traditionally, chest radiography (CR) is used to identify true CAP. However, CR is not a perfect diagnostic test for CAP. The use of lung ultrasonography (LUS) has been suggested as an alternative to overcome the problems associated with CR and increase the feasibility and accuracy of CAP diagnosis. LUS has largely been used for the diagnosis of several lung problems, including CAP, in adult patients with satisfactory results...
December 19, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29246216/association-analysis-of-ilvbl-gene-polymorphisms-with-aspirin-exacerbated-respiratory-disease-in-asthma
#18
Hun Soo Chang, Jong Sook Park, Ho Sung Lee, Jiwon Lyu, Ji-Hye Son, Inseon S Choi, Hyoung Doo Shin, Choon-Sik Park
BACKGROUND: We previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV1) after an oral aspirin challenge test. In this study, we confirmed the association between polymorphisms and haplotypes of the ILVBL gene and the risk for AERD and its phenotype. METHODS: We recruited 141 AERD and 995 aspirin-tolerant asthmatic (ATA) subjects...
December 16, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29246211/a-cluster-analysis-of-chronic-obstructive-pulmonary-disease-in-dusty-areas-cohort-identified-three-subgroups
#19
Suhyun Kim, Myoung-Nam Lim, Yoonki Hong, Seon-Sook Han, Seung-Joon Lee, Woo Jin Kim
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with variable clinical manifestations, structural changes, and treatment responses. In a cohort study, we performed a baseline cluster analysis to identify the subgroups of COPD and to assess the clinical outcomes of each subgroup during a 1-year follow-up. METHODS: We analyzed dusty areas cohort comprising 272 patients with COPD. The main factors with the highest loading in 15 variables were selected using principal component analysis (PCA) at baseline...
December 16, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29246210/rates-and-risk-factors-associated-with-hospitalization-for-pneumonia-with-icu-admission-among-adults
#20
Aaron D Storms, Jufu Chen, Lisa A Jackson, James D Nordin, Allison L Naleway, Jason M Glanz, Steven J Jacobsen, Eric S Weintraub, Nicola P Klein, Paul M Gargiullo, Alicia M Fry
BACKGROUND: Pneumonia poses a significant burden to the U.S. health-care system. However, there are few data focusing on severe pneumonia, particularly cases of pneumonia associated with specialized care in intensive care units (ICU). METHODS: We used administrative and electronic medical record data from six integrated health care systems to estimate rates of pneumonia hospitalizations with ICU admissions among adults during 2006 through 2010. Pneumonia hospitalization was defined as either a primary discharge diagnosis of pneumonia or a primary discharge diagnosis of sepsis or respiratory failure with a secondary diagnosis of pneumonia in administrative data...
December 16, 2017: BMC Pulmonary Medicine
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