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BMC Pulmonary Medicine

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https://www.readbyqxmd.com/read/27905913/sera-from-severe-trauma-patients-with-pneumonia-and-without-infectious-complications-have-differential-effects-on-neutrophil-biology
#1
B Relja, R Taraki, M P J Teuben, K Mörs, N Wagner, S Wutzler, F Hildebrand, M Perl, I Marzi
BACKGROUND: Major trauma patients (TP) developing imbalanced immune response are at high risk for infectious post-injury complications including pneumonia. Neutrophils play a central role in the host defense against bacteria and thereby pathogenesis of infections. While there are numerous studies about neutrophil function after trauma, data about their biology in patients who suffer from pneumonia following trauma are sparse. Here, we studied the effect of serum isolated from patients who do and do not develop infection (inf...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27905908/the-balance-between-the-serum-levels-of-il-6-and-il-10-cytokines-discriminates-mild-and-severe-acute-pneumonia
#2
Rita de Cássia Coelho Moraes de Brito, Norma Lucena-Silva, Leuridan Cavalcante Torres, Carlos Feitosa Luna, Jaílson de Barros Correia, Giselia Alves Pontes da Silva
BACKGROUND: To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between serum cytokine profile of children with different pneumonia severity. METHODS: In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests, Pearson correlation and ROC curve for cut-off definition of cytokines...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27905903/immediate-effect-of-cpap-titration-on-perceived-health-related-quality-of-life-a-prospective-observational-study
#3
Serena Iacono Isidoro, Adriana Salvaggio, Anna Lo Bue, Salvatore Romano, Oreste Marrone, Giuseppe Insalaco
BACKGROUND: Perceived Health Related Quality of Life (HRQoL) is impaired in obstructive sleep apnea (OSA). This study examines changes in HRQoL aspects occurring immediately after CPAP titration. Furthermore, we analyzed variations in each gender and in patients undergoing home or laboratory-based CPAP titration pathways. METHODS: Twohundredfive outpatients (151 M) (56.7 ± 10.3 years) were evaluated, before first visit and nocturnal diagnostic examination (T0), and the morning after CPAP titration (T1)...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27903260/clinical-physiologic-and-radiographic-factors-contributing-to-development-of-hypoxemia-in-moderate-to-severe-copd-a-cohort-study
#4
J Michael Wells, Raul San Jose Estepar, Merry-Lynn N McDonald, Surya P Bhatt, Alejandro A Diaz, William C Bailey, Francine L Jacobson, Mark T Dransfield, George R Washko, Barry J Make, Richard Casaburi, Edwin J R van Beek, Eric A Hoffman, Frank C Sciurba, James D Crapo, Edwin K Silverman, Craig P Hersh
BACKGROUND: Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little is known about characteristics that predict onset of resting hypoxemia in patients who are normoxic at baseline. We hypothesized that a combination of clinical, physiologic, and radiographic characteristics would predict development of resting hypoxemia after 5-years of follow-up in participants with moderate to severe COPD METHODS: We analyzed 678 participants with moderate-to-severe COPD recruited into the COPDGene cohort who completed baseline and 5-year follow-up visits and who were normoxic by pulse oximetry at baseline...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27903248/long-term-clinical-course-of-anti-glycyl-trna-synthetase-anti-ej-antibody-related-interstitial-lung-disease-pathologically-proven-by-surgical-lung-biopsy
#5
Hajime Sasano, Eri Hagiwara, Hideya Kitamura, Yasunori Enomoto, Norikazu Matsuo, Tomohisa Baba, Shinichiro Iso, Koji Okudela, Tae Iwasawa, Shinji Sato, Yasuo Suzuki, Tamiko Takemura, Takashi Ogura
BACKGROUND: Anti-glycyl-tRNA synthetase (anti-EJ) antibody is occasionally positive in patients with interstitial lung disease (ILD). We aimed to define the clinical, radiological and pathological features of patients with anti-EJ antibody-positive ILD (EJ-ILD). METHODS: We retrospectively analyzed the medical records of 12 consecutive patients with EJ-ILD who underwent surgical lung biopsy. RESULTS: The median follow-up time was 74 months (range, 17-115 months)...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27899105/non-invasive-mechanical-ventilation-after-heart-surgery-in-children
#6
Sarah Fernández Lafever, Blanca Toledo, Miguel Leiva, Maite Padrón, Marina Balseiro, Angel Carrillo, Jesús López-Herce
BACKGROUND: The purpose of the study was to analyze the characteristics and evolution of non-invasive mechanical ventilation (NIV) in the postoperative period of heart surgery in children. METHODS: Retrospective observational study including all children requiring NIV after heart surgery in a single center pediatric intensive care unit (PICU) between 2001 and 2012. Demographic characteristics, ventilation parameters and outcomes were registered, comparing the first 6 years of the study with the last 6 years...
November 29, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27894283/small-lung-lesions-invisible-under-fluoroscopy-are-located-accurately-by-three-dimensional-localization-technique-on-chest-wall-surface-and-performed-bronchoscopy-procedures-to-increase-diagnostic-yields
#7
Chaosheng Deng, Xiaoming Cao, Dawen Wu, Haibo Ding, Ruixiong You, Qunlin Chen, Linying Chen, Xin Zhang, Qiaoxian Zhang, Yongquan Wu
BACKGROUND: Nowadays, small peripheral pulmonary lesions (PPLs) are frequently detected and the prognosis of lung cancer depends on the early diagnosis. Because of the high fee and requiring specialized training, many advanced techniques are not available in many developing countries and rural districts. METHODS: Three sets of opaque soft copper wires visible under the fluoroscopy (Flu) in the Flu-flexible bronchoscopy (FB) group (n = 24), which determined the three planes of the lesion, were respectively placed firmly on the surface of the chest wall with adhesive tape on the chest wall...
November 29, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27894280/is-there-any-association-between-sarcoidosis-and-infectious-agents-a-systematic-review-and-meta-analysis
#8
Tiago Esteves, Gloria Aparicio, Vicente Garcia-Patos
BACKGROUND: During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines...
November 28, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27887619/the-prognostic-value-of-measurement-of-high-sensitive-cardiac-troponin-t-for-mortality-in-a-cohort-of-stable-chronic-obstructive-pulmonary-disease-patients
#9
Anke Neukamm, Gunnar Einvik, Arne Didrik Høiseth, Vidar Søyseth, Nils Henrik Holmedahl, Natalia Kononova, Torbjørn Omland
BACKGROUND: Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD). Cardiac troponin (cTn) elevation, indicating myocardial injury, is frequent during acute COPD exacerbations and associated with increased mortality. The prognostic value of circulating cTnT among COPD patients in the stable state of the disease is still unknown. The purpose of the present study was to assess the association between circulating cTnT measured by a high sensitive assay (hs-cTnT) and all-cause mortality among patients with stable COPD without overt CVD...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27887611/the-performance-of-interferon-gamma-release-assay-in-nontuberculous-mycobacterial-diseases-a-retrospective-study-in-china
#10
Mao-Shui Wang, Jun-Li Wang, Xin-Feng Wang
BACKGROUND: The interferon-gamma release assay (IGRA) is more specific than the tuberculin skin test to discriminate between tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases. Here we performed a retrospective study to evaluate the performance of the T-SPOT.TB in patients with NTM diseases. METHODS: Between March, 2013 and Nov, 2015, a total of 58 patients with NTM diseases had a T-SPOT.TB performed were enrolled, 30 patients had definite NTM diseases, 28 had probable diseases...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27884188/dietary-patterns-are-associated-with-lung-function-among-spanish-smokers-without-respiratory-disease
#11
Mar Sorli-Aguilar, Francisco Martin-Lujan, Gemma Flores-Mateo, Victoria Arija-Val, Josep Basora-Gallisa, Rosa Sola-Alberich
BACKGROUND: Diet can help preserve lung function in smokers, in addition to avoidance of smoking. The study aimed to evaluate associations between dietary patterns and lung function in smokers without respiratory disease. METHODS: This cross-sectional study analysed baseline data from randomised representative smokers without respiratory disease (n = 207, aged 35-70 years), selected from 20 primary health-care centres. Participants completed a validated semi-quantitative food-frequency questionnaire...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27884176/localization-of-bleeding-sites-in-patients-with-hemoptysis-based-on-their-chest-computed-tomography-findings-a-retrospective-cohort-study
#12
Hyun Ju Seon, Yun-Hyeon Kim, Yong-Soo Kwon
BACKGROUND: The aim of this study was to propose a localization strategy for bleeding sites in hemoptysis patients using their chest computed tomography (CT) findings. METHODS: Between January 2005 and July 2009, the chest CT findings of 161 hemoptysis patients were retrospectively reviewed. Following chest CT, the lobe with the most prominent ground glass attenuation (GGA) or specific lesions with the potential to cause pulmonary hemorrhage were analysed to develop a localization strategy for bleeding sites...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27884144/assessment-of-serology-and-spirometry-and-the-combination-of-both-to-complement-microbiological-isolation-for-earlier-detection-of-pseudomonas-aeruginosa-infection-in-children-with-cystic-fibrosis
#13
Ana Kotnik Pirš, Uroš Krivec, Saša Simčič, Katja Seme
BACKGROUND: The aim of this study was to assess whether serology and spirometry and the combination of both can complement culture-based detection for earlier recognition of Pseudomonas aeruginosa infection in children with cystic fibrosis. METHODS: A 4 year longitudinal prospective study that included 67 Slovenian children with cystic fibrosis with a mean age of 10.5 years was conducted. Serology, spirometry and a scoring system combining serology and spirometry were assessed and compared...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27881161/lower-hypoxic-ventilatory-response-in-smokers-compared-to-non-smokers-during-abstinence-from-cigarettes
#14
Wulf Hildebrandt, Roland Sauer, Ulrich Koehler, Peter Bärtsch, Ralf Kinscherf
BACKGROUND: Carotid body O2-chemosensitivity determines the hypoxic ventilatory response (HVR) as part of crucial regulatory reflex within oxygen homeostasis. Nicotine has been suggested to attenuate HVR in neonates of smoking mothers. However, whether smoking affects HVR in adulthood has remained unclear and probably blurred by acute ventilatory stimulation through cigarette smoke. We hypothesized that HVR is substantially reduced in smokers when studied after an overnight abstinence from cigarettes i...
November 24, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27881110/prevalence-of-chronic-kidney-disease-in-patients-with-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#15
Swarna Gaddam, Sameer K Gunukula, James W Lohr, Pradeep Arora
BACKGROUND: The incidence and prevalence of chronic kidney disease (CKD) continue to rise worldwide. Increasing age, diabetes, hypertension, and cigarette smoking are well-recognized risk factors for CKD. Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation leading to airway obstruction and parenchymal lung destruction. Due to some of the common pathogenic mechanisms, COPD has been associated with increased prevalence of CKD. METHODS: Systematic review of medical literature reporting the incidence and prevalence of CKD in patients with COPD using the Cochrane Collaboration Methodology, and conduct meta-analysis to study the cumulative effect of the eligible studies...
November 24, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27876029/home-telemonitoring-for-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-a-randomized-controlled-trial
#16
Andrea Vianello, Massimo Fusello, Lorenzo Gubian, Claudia Rinaldo, Claudio Dario, Alessandra Concas, Claudio Saccavini, Laura Battistella, Giulia Pellizzon, Giuseppe Zanardi, Silvia Mancin
BACKGROUND: Although a number of studies have suggested that the use of Telemonitoring (TM) in patients with Chronic Obstructive Pulmonary Disease (COPD) can be useful and efficacious, its real utility in detecting Acute Exacerbation (AE) signaling the need for prompt treatment is not entirely clear. The current study aimed to investigate the benefits of a TM system in managing AE in advanced-stage COPD patients to improve their Health-Related Quality of Life (HRQL) and to reduce utilization of healthcare services...
November 22, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27863518/safety-and-efficacy-of-bridging-to-lung-transplantation-with-antifibrotic-drugs-in-idiopathic-pulmonary-fibrosis-a-case-series
#17
Isabelle Delanote, Wim A Wuyts, Jonas Yserbyt, Eric K Verbeken, Geert M Verleden, Robin Vos
BACKGROUND: Following recent approval of pirfenidone and nintedanib for idiopathic pulmonary fibrosis (IPF), questions arise about the use of these antifibrotics in patients awaiting lung transplantation (LTx). METHODS: Safety and efficacy of antifibrotic drugs in IPF patients undergoing LTx were investigated in a single-centre retrospective cohort analysis. RESULTS: A total of nine patients, receiving antifibrotic therapy for 419 ± 315 days until subsequent LTx, were included...
November 18, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27855686/combined-ultrasound-guided-cutting-needle-biopsy-and-standard-pleural-biopsy-for-diagnosis-of-malignant-pleural-effusions
#18
Jinlin Wang, Xinghua Zhou, Xiaohong Xie, Qing Tang, Panxiao Shen, Yunxiang Zeng
BACKGROUND: The most efficient approach to diagnose malignant pleural effusions (MPEs) is still controversial and uncertain. This study aimed to evaluate the utility of a combined approach using ultrasound (US)-guided cutting-needle biopsy (CNB) and standard pleural biopsy (SPB) for diagnosing MPE. METHODS: Pleural effusions were collected from 172 patients for biochemical and microbiological analyses. US-guided CNB and SPB were performed in the same operation sequentially to obtain specimens for histological analysis...
November 17, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27855675/are-sleep-disorders-associated-with-increased-mortality-in-asthma-patients
#19
Kyu-Tae Han, Hong-Chul Bae, Sang Gyu Lee, Seung Ju Kim, Woorim Kim, Hyo Jung Lee, Yeong Jun Ju, Eun-Cheol Park
BACKGROUND: South Korea has experienced problems regarding poor management of symptoms of asthma patients and remarkable increases in sleep disorders. However, few studies have investigated these issues. We examined the relationship between sleep disorders and mortality in asthma patients to suggest effective alternatives from a novel perspective. METHODS: We used data from the National Health Insurance Service (NHIS) National Sample Cohort 2004-2013, which included medical claims filed for 186,491 patients who were newly diagnosed with asthma during the study period...
November 17, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27852260/can-severe-asthmatic-patients-achieve-asthma-control-a-systematic-approach-in-patients-with-difficult-to-control-asthma-followed-in-a-specialized-clinic
#20
Rodrigo Athanazio, Regina Carvalho-Pinto, Frederico Leon Arrabal Fernandes, Samia Rached, Klaus Rabe, Alberto Cukier, Rafael Stelmach
BACKGROUND: Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protocol, including oral corticosteroids, budesonide/formoterol maintenance and reliever therapy and a multidisciplinary approach to improve adherence. METHODS: Non-controlled (NC) SA patients were enrolled to receive 2 weeks of oral corticosteroids and 12 weeks of formoterol + budesonide...
November 16, 2016: BMC Pulmonary Medicine
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