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BMC Psychiatry

Rossela Roberts, Abigail Neasham, Chania Lambrinudi, Afshan Khan
BACKGROUND: In recent decades atypical antipsychotics have increased treatment options available for schizophrenia, however there is conflicting evidence concerning the trade-off between clinical efficacy and side effects for the different classes of antipsychotics. There has been a consistent increase in atypical antipsychotic prescribing compared to typical, despite evidence showing that neither class is superior. This leads to the question of whether prescribers are selective in their uptake of research evidence and clinical guidelines and if so, what influences their choice...
September 10, 2018: BMC Psychiatry
Richard Vijverberg, Robert Ferdinand, Aartjan Beekman, Berno van Meijel
BACKGROUND: More knowledge about characteristics of children and adolescents who need intensive levels of psychiatric treatment is important to improve treatment approaches. These characteristics were investigated in those who need youth Assertive Community Treatment (youth-ACT). METHOD: A cross-sectional study among children/adolescents and their parents treated in either a regular outpatient clinic or a youth-ACT setting in a specialized mental health treatment center in the Netherlands...
September 10, 2018: BMC Psychiatry
Melanie S Richter, Ken O'Reilly, Danny O'Sullivan, Padraic O'Flynn, Aiden Corvin, Gary Donohoe, Ciaran Coyle, Mary Davoren, Caroline Higgins, Orla Byrne, Tina Nutley, Andrea Nulty, Kapil Sharma, Paul O'Connell, Harry G Kennedy
BACKGROUND: We evaluated change in response to multi-modal psychosocial 'treatment as usual' programs offered within a forensic hospital. METHODS: Sixty nine patients with a diagnosis of schizophrenia or schizoaffective disorder were followed for up to four years. Patient progress was evaluated using the DUNDRUM-3, a measure of patient ability to participate and benefit from multi-modal psychosocial programs and the HCR-20 dynamic items, a measure of violence proneness...
September 8, 2018: BMC Psychiatry
Jaco Rossouw, Elna Yadin, Debra Alexander, Soraya Seedat
BACKGROUND: There is a dearth of empirical evidence on the effectiveness of pharmacological and non-pharmacological treatments for adolescents with posttraumatic stress disorder (PTSD) in developing countries. The primary aim of the study is to examine the effects of prolonged exposure therapy compared with supportive counseling for adolescents with PTSD delivered by nurses trained as counselors. METHODS/DESIGN: A single-blind randomized clinical trial comprising 90 adolescents with PTSD using a permuted block design will be utilized...
September 6, 2018: BMC Psychiatry
Juliette Salles, Julie Calonge, Nicolas Franchitto, Emmanuelle Bougon, Laurent Schmitt
BACKGROUND: Previous studies have identified factors associated with admission to hospital after suicide spectrum behaviors. In this study, we aim to identify specific factors associated with psychiatric hospitalization after self-poisoning. Given earlier findings suggesting that alcohol use disorder is not associated with hospital admission, we also aim to consider its impact, as well as blood alcohol concentrations, on hospitalization decisions after a suicide attempt. METHODS: We studied the association between demographic features, suicide intent, psychiatric characteristics and admission to hospital in self-poisoning patients in an emergency department in France...
September 6, 2018: BMC Psychiatry
Peng Men, Zhanmiao Yi, Chaoyun Li, Shuli Qu, Tengbin Xiong, Xin Yu, Suodi Zhai
BACKGROUND: Amisulpride was introduced into China in 2010 as a second-generation atypical antipsychotic, while olanzapine has been on the market since 1999 as one of the leading treatments for schizophrenia in China. Since more Chinese patients are gaining access to amisulpride, the study aims to compare the efficacy, safety, and costs between amisulpride and olanzapine for schizophrenia treatment in China. METHODS: PubMed, Embase, the Cochrane library, China National Knowledge Infrastructure (CNKI) and WanFang database were systematically searched for randomized controlled trials (RCTs) up to July 2018...
September 5, 2018: BMC Psychiatry
Caihong Sun, Mingyang Zou, Xuelai Wang, Wei Xia, Yongjuan Ma, Shuang Liang, Yanqiu Hao, Lijie Wu, Songbin Fu
BACKGROUD: Autism spectrum disorders (ASD) are a complex group of neurodevelopmental disorders with a genetic basis. The role of long-chain polyunsaturated fatty acids (LC-PUFAs) and the occurrence of autism has been the focus of many recent studies. The present study investigates whether genetic variants of the fatty acid desaturase (FADS) 1/2 and elongation of very long-chain fatty acids protein (ELOVL) 2 genes, which are involved in LC-PUFA metabolism, are associated with ASD risk...
September 4, 2018: BMC Psychiatry
Susan Young, Gisli Gudjonsson, Prathiba Chitsabesan, Bill Colley, Emad Farrag, Andrew Forrester, Jack Hollingdale, Keira Kim, Alexandra Lewis, Sarah Maginn, Peter Mason, Sarah Ryan, Jade Smith, Emma Woodhouse, Philip Asherson
BACKGROUND: Around 25% of prisoners meet diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD). Because ADHD is associated with increased recidivism and other functional and behavioural problems, appropriate diagnosis and treatment can be a critical intervention to improve outcomes. While ADHD is a treatable condition, best managed by a combination of medication and psychological treatments, among individuals in the criminal justice system ADHD remains both mis- and under-diagnosed and consequently inadequately treated...
September 4, 2018: BMC Psychiatry
Ruth A Sibbett, Tom C Russ, Mike Allerhand, Ian J Deary, John M Starr
BACKGROUND: Previous studies have demonstrated that individual measures of fitness - such as reduced pulmonary function, slow walking speed and weak handgrip - are associated with an increased risk of dementia. Only a minority of participants included in these studies were aged over 80. The aim of this study was therefore to investigate the association between physical fitness and dementia in the oldest old. METHODS: Subjects (n = 488) were enrolled in the Lothian Birth Cohort 1921 and aged 79 at baseline...
September 4, 2018: BMC Psychiatry
Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Rosanne Freak-Poli, Richard Saffery, Joanne Ryan
BACKGROUND: Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DNA methylation at the promoter CpG island. Few studies have explored the influence of genetic variation across the gene on DNA methylation, and their combined association with depression risk. The aim of this study was to determine whether genetic variation in the SLC6A4 gene influences promoter DNA methylation, and whether these are associated with depression status...
September 4, 2018: BMC Psychiatry
Matilde Elices, Juan C Pascual, Cristina Carmona, Ana Martín-Blanco, Albert Feliu-Soler, Elisabet Ruiz, Montserrat Gomà-I-Freixanet, Víctor Pérez, Joaquim Soler
In the original publication of this article [1] the funding acknowledgement for grant "PI13/00134, ERDF Funds" was missing.
September 4, 2018: BMC Psychiatry
Min-Hyeon Park, Subin Park, Kyu-In Jung, Johanna Inhyang Kim, Soo Churl Cho, Bung-Nyun Kim
BACKGROUND: Adolescence is a period of marked sleep pattern changes and sleep problems, which may result from both endogenous and exogenous factors. Among the various factors affecting adolescent sleep, depression and problematic Internet use (PIU) have received considerable attention. We examined if there is a different PIU effect on sleep between depressed group and non-depressed groups. METHODS: Data for a total of 766 students' between 7th and 11th grades were analyzed...
September 4, 2018: BMC Psychiatry
Chenghao Yang, Fokko J Bosker, Jie Li, Robert A Schoevers
BACKGROUND: A subgroup of depressed patients with increased inflammatory activity was shown to be more susceptible to develop Treatment Resistant Depression (TRD). Earlier studies with anti-inflammatory drugs have shown benefits in the treatment of major depressive disorder (MDD), but the effects are expected to be higher in patients with increased inflammatory activity. Supplementation of N-acetylcysteine (NAC) to ongoing antidepressant therapy may positively influence outcome of depression treatment in these patients...
September 4, 2018: BMC Psychiatry
Nobuhisa Kanahara, Hiroshi Yamanaka, Tomotaka Suzuki, Masayuki Takase, Masaomi Iyo
BACKGROUND: Approximately one-third of schizophrenia patients eventually develop treatment-resistant schizophrenia (TRS). Although the time course of TRS development varies from patient to patient, the details of these variations have not been clarified. The present study compared the duration of time required to achieve control of the first-episode psychosis (FEP) between patients who went on to develop TRS and those who did not, in order to determine whether a bifurcation point exists for the transition to TRS...
September 3, 2018: BMC Psychiatry
Silvia Hurtado-Santiago, José Guzmán-Parra, Rosa M Bersabé, Fermín Mayoral
BACKGROUND: Borderline personality disorder (BPD) is associated with an intensive use of mental health services, even in the absence of a full diagnosis. Early symptom detection and intervention may help alleviate adverse long-term outcomes. Iconic Therapy is an innovative manual-driven psychotherapy that treats BPD symptoms in a specific and intensive manner. Preliminary results are promising and the indication is that Iconic Therapy may be effective in reducing BPD symptoms. The aim of this study is to assess how effective Iconic Therapy is compared to Structured Support Therapy in a real clinical setting...
September 3, 2018: BMC Psychiatry
Li-Yu Hu, Chia-Jen Liu, Chiu-Mei Yeh, Ti Lu, Yu-Wen Hu, Tzeng-Ji Chen, Pan-Ming Chen, Shyh-Chyang Lee, Cheng-Ho Chang
BACKGROUND: In cancer patients, depressive disorder comorbidity is associated with greater suicide risk and poorer treatment outcomes, quality of life, and adherence to treatment. The aim of the study was to evaluate the incidence of newly-diagnosed depressive disorders after a gastric cancer diagnosis compared with a matched cohort using the National Health Insurance Research Database in Taiwan. METHODS: We conducted a retrospective cohort study of 57,506 patients (28,753 patients with gastric cancer and 28,753 matched patients) selected from the National Health Insurance Research Database...
September 3, 2018: BMC Psychiatry
Jojanneke A Bastiaansen, Maaike Meurs, Renee Stelwagen, Lex Wunderink, Robert A Schoevers, Marieke Wichers, Albertine J Oldehinkel
BACKGROUND: Depression is a leading cause of disability worldwide. To reduce the societal burden and improve quality of life for individual patients, treatments for depression need to be optimized. There is a particular need for person-tailored interventions that reinforce self-management of patients. Systematic self-monitoring and personalized feedback through the Experience Sampling Method (ESM) could provide such a person-tailored, empowering intervention that enhances treatment outcomes...
September 3, 2018: BMC Psychiatry
Sharea Ijaz, Blanca Bolea, Simon Davies, Jelena Savović, Alison Richards, Sarah Sullivan, Paul Moran
BACKGROUND: There is conflicting evidence on the association between antipsychotic polypharmacy and metabolic syndrome in schizophrenia. We conducted a review of published systematic reviews to evaluate evidence on the association between metabolic syndrome (diabetes, hypertension, and hyperlipidaemia) and exposure to antipsychotic polypharmacy in schizophrenia. METHODS: We searched five electronic databases, complemented by reference screening, to find systematic reviews that investigated the association of antipsychotic polypharmacy in schizophrenia with hypertension, diabetes, or hyperlipidaemia...
September 3, 2018: BMC Psychiatry
Qiao Zhang, Jia-Jiang Xie
BACKGROUND: Previous studies have shown that patients with mental illnesses such as schizophrenia have a higher risk for syphilis infection. However, the clinical characteristics of psychotic patients who are infected with syphilis remain unknown. The aim of this study was to investigate the prevalence of syphilis in psychotic patients in Xiamen and to compare the social function and serum biochemical markers between schizophrenia patients with and without syphilis. METHODS: There were a total of 1586 psychotic patients screened for syphilis from May 2016 to August 2017 in Xiamen Mental Health Center...
September 3, 2018: BMC Psychiatry
Jakob Johne, Sebastian von Peter, Julian Schwarz, Jürgen Timm, Martin Heinze, Yuriy Ignatyev
BACKGROUND: Flexible and integrative treatment (FIT) models are rather novel in German mental health care. This study aimed at identifying and evaluating empirically based, practicable, and quantifiable program components that describe the specific treatment structures and processes of German FIT models. METHODS: A multi-step, iterative research process, based on Grounded Theory Methodology (GTM), was used to identify and operationalise components. A complex algorithm and expert-interviews were applied to quantify the relative weight of each component and to develop a sum score...
September 3, 2018: BMC Psychiatry
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